Messages From the Director

Thoughts from the Director of the Huck Institutes

Andrew Read

COVID-19 (+1)

Huck’s Pulse newsletter is a little different this month folks, for obvious reasons. In lieu of my regular “Angle” column, I offer the following three items: (1) COVID comms, (2) COVID research, and – wait for it – (3) non-COVID research.

(1) Like a giant celestial object, a tiny virus has warped time. For some in our community, everything has slowed to a crawl. Others are racing faster than ever. Our infectious disease researchers, for example, have been accelerated to warp speed. Not only are they heavily involved in COVID-research, they are being inundated by requests for expert opinion from journalists, university leadership, the curious public, family, and colleagues. This is one aspect of a pandemic preparedness I had never foreseen: a hunger to have the media deluge interpreted.

In an attempt to push out our expertise without crushing the experts, the Huck com team has collaborated with Center for Infectious Disease Dynamics (CIDD) faculty to launch an “Ask CIDD” initiative. The public submit their COVID questions and our team answers the most popular ones via video with the most scientifically accurate, up-to-date info available. So far, they’ve been able to publish one video per day, M-F. Subscribe to these videos here.   

(2) Since our last newsletter (really, just a month ago?), we stood up what we’re told was the first coronavirus seed grant scheme at any US university. So far, we’ve got $1.25m to researchers, with more to come. It’s been amazing. Within a day of going live, all the OSVPR Research Institutes were involved – which speaks to the fantastic working relationship we have. Less than a month later and we’ve had well over 100 proposals! You can see some of what we’ve funded in the first rounds here .

The intellectual breadth of what PSU has to offer is stunning: everything from angstrom-resolution of the viral surface to vaccines and therapeutics to diagnostics to hygiene to patients to hospital management to environmental sampling to global health modelling to social and community population health….. Whatever happens in the coming weeks and months, it has made me very proud that we – the Penn State Research Institutes – are capable of supporting work with outstanding promise with such speed.

Thanks so much to all the Huck staff who, behind the scenes, have also been at warp speed, the Huck Exec, my fellow Institute directors and particularly Beth McGraw who is chairing the process (now time for a G&T?). Most of all, thanks to the researchers who have stepped up with ideas, expertise and technology. Godspeed. Make us proud.

(3) In gentler times (really, just three months ago?), I wrote of why we at Huck are passionate about supporting truly high-risk/high pay-off research (if we don’t, who else will?). Despite everything that is happening around us now – perhaps even more so ­– we remain totally committed to that view. Penn State, the nation and the world are better when our scientists think out of the box. So, we are going to continue with our HITS seed fund. We’ve pushed the deadline to May 1 give you and us some breathing room, but otherwise we’re still going for it. Our screening process will be simple: (1) if the idea works, will it have big impact?, and (2) will our support de-risk it for conventional funders? Think bold, folks.

At this moment, all of us face a chaotic and uncertain collective future – one in which countless people have had their lives completely upended. Those of us who are still able to do meaningful work in the face of it are among the most fortunate in the world. Let’s make the most of this opportunity to be of service and make a positive difference.

If not us, who?  

- Andrew

Past Messages:

2020

Unless something miraculous happens, humanity just gained itself another virus. With luck (and a lot of hard work), a highly effective vaccine will become available, and herd immunity will render the latest coronavirus a thing of the past. But we’ll have to be awfully lucky: humanity has only ever eradicated one human pathogen (smallpox), and vaccine development takes years. Right now, we can only guess at the deaths and societal disruption to come in the next few months.

Throughout human history, infections have spilled from animals into humans, as did this one. When humans lived in small groups, many outbreaks undoubtedly fizzled out. But as human populations grew large enough, spillover pathogens were able to permanently sustain themselves on us (measles). These days, advances in microbiology and public health make it possible to catch some early and eradicate them (SARS). But many get away (HIV, 2019-nCoV).

Odds are that spillovers will become more common. The human population has doubled in my lifetime, and it will continue to rise for decades. That’s an awful lot more animal-people contact, especially as resources get stressed and environments disrupted. Combined with density-dependent transmission and unprecedented human mobility across the planet... well, we’re in parameter space no species has ever experienced.

It’s hard to judge the threat. We don’t yet know what the COVID-19 fatality rate is, but it looks substantially lower than SARS. We don’t know if the next spillover will be worse or better; right now, we don’t even know enough to predict whether 2019-nCoV itself will evolve to become more or less virulent in the coming years.

Like many challenges facing humanity, science is key to spillover mitigation. Here at Penn State we have one of the largest groupings of co-located infectious disease scientists anywhere, with some of the best facilities. Moreover, our expertise lies across all the scales involved, from angstrom-level structure and chemistry on the surface of virus particles (Center for Structural Biology) to global pandemic preparedness and vaccine implantation strategies (Center for Infectious Disease Dynamics). Hear three of our sharpest minds talk about their work on infectious disease dynamics in this month’s Symbiotic Podcast.

As we confront the challenge of global outbreaks, effective international collaboration is an absolute necessity. With that in mind, I am proud to say that Penn State was the first university in the US to sign on to a global coalition pledging rapid and open access to research data concerning the outbreak.

Whatever happens, we want to stay at the forefront. The life sciences are going to be key for dealing with spillovers, but so too the social sciences, law, policy, economics, communication science, advanced computing and mathematics, and new sensing technologies. Penn State’s leadership is committed to pushing boundaries across each of these fields.

For our part, Huck will continue to not only build on those strengths but also to facilitate seamless intellectual movement between them.

We have to. There is going to be a lot more to do.

- Andrew

If you imagine the 21st century as a five-day work week, hitting 2020 means Monday is over. What should we do with Tuesday?

At Huck, we’re aiming for more disruption and failure. But not for their own sake. We’re after disruption and failure with a purpose. Our thinking is simple. Truly innovative and transformational research never starts with a ‘safe bet.’ That means we have to be prepared to make unsafe bets...

So, with great enthusiasm and a BIG financial gulp, we are resurrecting the Huck Innovative & Transformational Seed (HITS) Fund.

This program is designed to foster projects with knock-your-socks-off potential that are too risky to secure conventional support. The application is simple. Persuade us that your idea will change important games if it pans out, and that none of the usual suspects will fund it. If we buy your argument, we’ll give you all the money we think you need to de-risk things for traditional funders. We’ll eat the financial loss if you fail, no questions asked. In return, you have to be ready to eat the time, bandwidth and opportunity cost if your idea is wrong.

Brave enough?

Huck ran this scheme before, just once, in 2012. The rubric was conceived on the I-99, when then-Huck Director Pete Hudson and I were coming back from DC, lamenting the incrementalism we’d just experienced.

Around that time, I vividly recall newly recruited Assistant Professor Marcel Salathe assert that ‘When safety comes first, America is lost’ (a line he attributed to a Roosevelt, but Google does not). That sentiment so captured the America of Possibilities I imagined as a child in New Zealand. I was eager to test it out and so was Pete.

There were 40 applications. I was amazed and disappointed we had so few. Huck does business with more than 500 faculty and even more grad students and post-docs, and only 40 have high-risk/high-payoff ideas? Worse, half the proposals were shovel-ready for NIH or NSF. Great stuff, but not bold. Of the remaining 20, we took a gamble on five or six. You can see four successes here. Clearly we did something wrong: 4 out of 5-6 is freakily successful.

Going forward and with a view to permanently raising aspirations, we will run the HITS call twice a year for as long as we can keep the money going. We want everyone at Penn State to incubate bold, high-risk/payoff ideas. Develop them. Bring them to us.

Choosing the proposals to fund will of course be a challenge. I am delighted to announce that Steve Benkovic—someone who knows a thing or two about high-payoff, risky science—has agreed to co-chair the process with me. We’ll populate the selection panel with an outsider or two and then, depending on applicant subject areas, we’ll ask big-thinking Penn State professors with subject expertise and no conflicts of interest to get involved.

Likely the selection panel will vary over time. We’ll get shortlisted applicants in for discussion and figure out with them how to hold their feet to the fire while simultaneously nurturing their idea to an agreed “GO/NO GO” point.

Everyone at Penn State should have at least one high risk-high payoff idea they can’t get funded. This is your chance to give it your best shot. Take a risk. Life is short. Bring us the ideas that would change the world if they pan out.

If nothing else, it will make for an exciting Tuesday.

- Andrew

2019

Nearing the end of my first year as Huck Director, I find myself pondering failure.

In a previous life, I did a lot of climbing in the New Zealand mountains. Among the climbing fraternity, well-intentioned failure was seen as the flip side of ‘no guts, no glory’. Failing was okay (so long as you stayed away from stupid). Indeed, the epic retreats, the disasters and the rescues, those became the folklore; the successes were just lines on a vitae. The folk really pushing the boundaries – the new routes, the winter routes – failed more often than they succeeded, but they changed what the rest of us did, aspired to, and even thought possible.

Science is also about pushing boundaries. Over the last year at Huck, I’ve heard a lot of stories about success, yet I can’t think of anyone telling me of abject failures. You know, the kind of thing that if it had come off, the Nobel would be in the bag, but instead it was a blow out. With very few exceptions, I hear no tales of breathtaking high-risk/high-payoff projects. I hope those projects are out there, because humanity needs game-changing science more than ever.

Bureaucratic risk aversion works against high-risk/high pay-off. In the name of efficiency and oversight, institutions carefully guard every dollar, worry about every hypothetical lawsuit, try to make every minute count. This rapidly leads to incrementalism, no more so than at the NIH and NSF. At both agencies, standard funding decisions have become so risk averse that separate schemes for high risk work have been created.

Penn State starts the new decade with a strategic planning round. I want to think more about how we can create an environment where our researchers can take major risks and be open about it. Money is some of the answer, but I think more it is about the culture. We need to celebrate those trying high-risk/high payoff. Minimally, that means enjoying each other’s tales of failure. Perhaps we need to include failure stories in future Huck newsletters.

Nobody wants everyone to gamble everything on crazy stuff. And we should all be on the lookout for the low-risk/high payoff projects. But they are rare. More common are low-risk/low payoff projects. We often need those in our portfolios to keep the lights on, but they will never change the game.

Just imagine a situation where everyone, from new grad students to professors to university administrators, could point to at least one high-risk initiative they took on. How many more high-payoff outcomes might emerge, and how much gloriously rich folklore would result from the failures?

There are endless routes to the top of the mountain, but new ones cannot be recognized until someone has the courage to envision them, gear up and have a go, even when success is far from guaranteed. What can Huck do that will be a game changer if it works, and nothing more than a learning experience if it does not?

My very best wishes for the Festive season. May your 2020 involve unsettling (intellectual) risk.

- Andrew

Last month, Penn State hosted SciWri 2019, a conference of 500+ science writers from all over the country. Huck was one of the biggest sponsors of the event and that meant we got to host four core facility tours, an insectary field trip, a live podcast panel, and a wildly popular Science Trivia game for the visiting community of journalists and academics.

Big shout out to Huck’s communication team, led by the irrepressible Cole Hons, for their enormous efforts. I am confident that some of the leading science journalists and writers in the country now have a much better idea of the breadth and expertise residing under the Huck umbrella.

My own immediate personal outcome of our involvement was an interview with NPR, conducted on the heels of a major new report about antibiotic resistant germs from The Centers for Disease Control and Prevention. This was the result of a talk I was asked to present by the organizers of SciWri 2019. Even challenging title they gave me – The Evolutionary Battlefield of Medicine: New Tactics Needed – seemed not so far from what I often talk about.

But as I dusted off one of my standard academic talks it was clear that something very different was called for. Nothing focuses the mind quite like the prospect of talking to an audience of smart, curious people who know nothing about your specialty – when you also know there will be subject matter experts in the room.

I was forced to think about the very big picture of what my research group and collaborators are about, and that was exceedingly stimulating. It also made me think through what differentiates our work from the mainstream and enunciate that. To me, it’s plain as day. But it turns out when you try to explain it to an audience like that, it’s not actually so obvious. Preparing the talk also made me rethink some of our research priorities. From 50,000 feet, you can really see the forest. I began to wonder about things we had not followed up and had new ideas about new research directions we might try.

I came away from the experience convinced that more faculty should do this kind of presenting. Of course, we can’t have a Science Writers convention every week. But we do have the Millennium Café, 10 a.m. each Tuesday on the third floor of the Millennium Science Complex. There, the Material Research Institute’s ever energetic and facilitating Josh Stapleton not only gets two speakers to talk about their subject expertise, but goes to extraordinary lengths to make sure they aim their expertise at non-specialists and possible collaborators outside their disciplines.

Not all faculty pull that off (sometimes, it is amazing what some geeks think constitutes an accessible talk). But many faculty do. Invariably, I find those sessions to be more reliably interesting than expert seminars in my own specialty. (They’re also shorter talks so you are not stuck for an hour if someone is droning on). The coffee and doughnuts are good too. I go whenever my schedule allows.

In today’s frantic drive for academic metrics – grant dollars in and scientific papers out – it is all too easy to lose track of the point of it all. As a hedge against this tendency, we should all be forced to take the time to step back and take a look at our position in the world, and then explain that to others. I think the discipline of talking to curious, smart non-subject matter experts is one outstanding way to avoid incrementalism – and, at least for me, to ask whether our day-to-day work in the weeds is truly aligned with an essential goal; understanding the forest.

- Andrew

Communication is critical to Huck’s mission of collaborative, impactful discovery. Because, let’s face it: scientific discovery is nothing but self-gratification if stakeholders don’t know about it. That’s why we and our partners put a lot of effort into communicating science. But it’s obvious that we could all do better: there is immense scope for new ideas and experiments. So bring us your ideas. We’re up for taking risks.

I see two aspects of communication related to what we do at the Huck that are ripe for new advances.

First, human behavior rarely changes of its own accord in response to scientific discoveries*. This is problematic, because overcoming most challenges facing humanity requires people to behave differently. The global challenge I am personally researching is the evolution and emergence of so-called superbugs, bacteria that can no longer be killed by previously effective antibiotics. By some estimates, these bugs will kill more people than cancer by 2050. A big part of the solution involves using antibiotics only when we need to, but that is easier said than done. For example, physicians know that prescribing antibiotics against viral infections is worse than useless, and the government keeps reminding them, but the problem persists at scale. Why? And if advice that simple is hard to follow, how will more complex solutions life scientists produce ever have impact?

I think communication science has a lot to offer. As a social science, it has the potential to uncover strategies that will lead to behavior change when scientifically-sound advice is not enough. In this month’s Symbiotic podcast, you can hear about my forays into this realm with Erina Macgeorge of the Department of Communication Arts and Science (CAS) in Penn State’s College of Liberal Arts.

We at the Huck are so encouraged with what is possible that we want to further build our partnership with CAS. We already have two faculty co-hires and are closing in on a third with a fourth slated for 2020-21. Additionally, we are preparing to launch an NIH-funded graduate course melding life and communication science (leads: Steve Schaeffer, Biology, and Rachel Smith, CAS). Finally, we are partnering with CAS on the Communication, Science and Society Initiative (CSSI). This is an experiment aimed at bringing communication and life scientists to work together on some of the major challenges facing humanity. It is being led by CAS’s Jim Dillard. Do reach out to Jim or our lead, Huck associate director Connie Rogers, if you want to know more. In a future column, I’ll describe the exciting partnership we have with the Social Science Research Institute to expand the work still further.

The other aspect of communication ripe for advances is central to Huck’s raison d’etre. We expect major advances when traditional disciplinary boundaries are spanned – but the most obvious sign that this is actually happening is when the participants cannot understand each other. Yet when jargon, concepts, theories, methodologies and scientific cultures are foreign, intellectual dissonance can lead faculty to go back to their disciplinary comfort zones. As I learned with Erina, it takes time to build trust and to understand each other’s language and way of thinking. I really believe communication science can also help address this problem.

Increasingly, people are talking of a science of science. A major part of that enterprise should be the study of scientist-to-scientist communication. Penn State is as good at peer-to-peer communication as any university and far better than most – but we have to get even better. Solutions to the world’s most serious challenges—from food security to neural basis of consciousness—require that truly transdisciplinary teams are unleashed. That requires superb peer-to-peer communication. The institutions that can do that best will change the world.

- Andrew

*One of the few examples might be the lines of parents queuing for the polio vaccine in the 1950s, when polio epidemics maimed American kids.

A curious thing about the Huck Institutes of the Life Sciences is that no other university appears to have anything quite like it. Think about that. Demonstrably, we aren’t necessary.

I love that. It means we exist only to make a difference. Good things, often excellent things, will happen if we do nothing; clearly, Colleges and Departments can flourish on their own. That perspective underpins everything I am trying to do as director. “If we do X, what difference will it make?” Of course, that’s also the way our game-changing staff and faculty think: “What difference am I making?”

‘Difference’, I think, boils down to impact, a hugely slippery concept. Many university administrators measure impact in terms of grant income, or financial efficiency, but of course that’s nonsense: dollars are the input. Impact is an output. My colleague Matt Thomas goes further: we should care less about outputs and more about outcomes. Scientific papers are outputs, and they really can generate outcomes. But papers needn’t be our only outputs, and infuriatingly, outcomes, even from papers, are really hard to measure. Sometimes, outcomes can be captured by citation counts or altimetric scores. But not always. If you actually solve a real world problem, it is often soon forgotten. Failing to solve a problem in an interesting way can better generate social media metrics and citations.

I think a real measure of impact is the extent to which we change the beliefs and practices of a constituency. Huck’s target constituency is staggeringly diverse. Certainly it includes our global fellow academics - a very important and exciting audience. But our constituency could also be policy makers (EPA, WHO), or the commercial landscape (Google), or those charged with human well-being (e.g. physicians, farmers), or the lay public, striving to better understand themselves and their world.

In the years to come, I very much look forward to the struggle of trying to balance that portfolio, perhaps one of the toughest challenges in scientific leadership. Right now, Huck is working on all the impact-enhancing initiatives we can construct. Bring us more. We exist to make special things happen.

- Andrew