The Biomolecular Interactions Core Facility provides the necessary infrastructure and support for individual investigators to undertake studies of macromolecule binding and folding, as well as protein and lipid quantification. Our calorimetry instruments are fully automated and require the least amount of sample of any commercially available instruments. Specifically, we provide instrumentation and collaborative assistance for:
- Isothermal titration calorimetry (ITC)for studying ligand-macromolecule binding
- Differential scanning calorimetry (DSC)for investigating stability and folding thermodynamics
- Multiwavelength Analytical Ultracentrifuge (AUC) for determining the hydrodynamic shape, size, molar mass and binding thermodynamics of any macromolecule and its complexes
- Circular Dichroism Spectrometer (CD) to determine aspects of protein secondary and tertiary structure
- Lumicks C-Trap a single-molecule force microscope with two optical tweezers correlated with confocal-fluorescence and label-free microscopy
Our experienced staff is available to assist with project development and research.
