CSL Behring Fermentation Facility hero image CSL Behring Fermentation Facility hero image

CSL Behring Fermentation Facility

The CSL Behring Fermentation Facility is a biotechnology pilot plant outfitted with state-of-the-art bioprocessing equipment for both research and development and pilot scale production applications. This facility houses equipment to produce microbial cells, recombinant proteins, and other microbial products over a wide range of controlled conditions and scales.

The CSL Behring Fermentation Facility is a biotechnology pilot plant capable of research- and pilot-scale production of microbial cells, recombinant proteins, and other microbial products over a wide range of controlled conditions. The facility provides equipment and expertise to university-affiliated and independent government and industry researchers interested in fermentation and related technologies, including cell separation and disruption, biomolecule production and purification, and process monitoring.

Upstream Capabilities

  • Two Innova 44 shaker incubators - one with refrigeration capability
  • Suite of Applikon 500mL mini bioreactors 
  • Sartorius Biostat B control units running 4 x 5L bioreactors
  • Sartorius stainless steel vessels ranging from 30L to 500L with full instrumentation
  • Sartorius MFCS supervisory control and data acquisition software with automation facilities
Upstream Capabilities

Biomass processing capabilities

  • Cell lysis through Microfluids LM-20-30 and M-110-EH systems
  • Culture broth separation via benchtop and floor centrifuges, Sharples T-1-P and AS-16 tube bowl centrifuges, and GEA Westfalia disk stack centrifuge
  • Labconoco FreeZone 18L freeze dryer with bulk tray dryer
Biomass processing capabilities

Purification and Analytical Capabilities

  • Tangential flow filtration through Sartorius SartoFlow Smart and Advanced units. Typically utilized for dialysis/diafiltration and concentration of proteins
  • Fast protein liquid chromatography via GE AKTA Pure 150M
  • Thermo Vanquish binary UHPLC system with UV-Vis Variable Wavelength and Refractive Index (RI) detectors
Purification and Analytical Capabilities