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Cryo-Electron Microscopy Facility

Empowering discovery with automated, high-throughput CryoEM and CryoSEM imaging workflows

The Huck Cryo-EM Facility at Penn State offers cutting-edge instrumentation and streamlined workflows to support high-impact research. Our facility features two cryogenic Transmission Electron Microscopes (TEMs), a versatile plasma Focused Ion Beam Scanning Electron Microscope (pFIB-SEM), and three semi-automated vitrification systems, enabling fast and efficient sample preparation and imaging. The addition of the pFIB-SEM significantly expands our capabilities, allowing us to support investigations ranging from molecular structures to whole cells and tissues. We proudly serve a diverse user base—from academic researchers to industry partners—and welcome collaborative projects across disciplines.​