Collage for hero banner of microbes

One Health Microbiome Center

As one of the largest and most active organizations in the field, the internationally awarded One Health Microbiome Center has a mission to optimize, accelerate, and disseminate long-lasting applications and knowledge on the microbiome.

Microbiomes are communities of microorganisms (e.g., bacteria, fungi, viruses, archaea, and protozoa) that inhabit an environment, including plants, animals, soils, oceans, and our homes. As we peer into our bodies, half of the cells in a human are microbes, and the gene catalogue of these human-associated microbes dwarfs that of our own human genome by at least 100-fold. Members of the microbiome can range from helpful to harmful, but notably the vast majority do not cause disease. As a collective, microbial assemblages and their genomes have profound impacts on solutions related to agricultural production, human chronic diseases, and ecosystem stability, among others. As we break ground on understanding how these diverse communities impact life, it is clear that the new study of the microbiome is central to biological systems, education, and applications in a rapidly changing world.

The center deeply embodies my vision for growing interdisciplinary excellence

—Penn State President Neeli Bendapudi, November 2024

550

Members

$224M

Awarded Funding

42+

Departments

100

Country Collaborations

9

American Academy of Microbiology Fellows

2000+

Publications in a Five-Year Period

First Ph.D

In Microbiome Science

Pierce Prize

First Ever Awarded to a Center, Not an Individual

News

Plant scientists receive $1.96M NIH grant to study plant-bacteria partnerships

A team of plant scientists in Penn State’s College of Agricultural Sciences has received a $1.96 million, five-year grant from the National Institutes of Health (NIH) to fund a study of how beneficial plant-bacteria partnerships evolve, persist, and can be harnessed to improve health and agriculture. This grant, called a Maximizing Investigator’s Research Award, supports a lab's long-term research vision rather than an individual project.

Medina, Paris receive 2026 Excellence in Advising Award

Scott Medina, the William and Wendy Korb Early Career Professor and Dorothy and J. Lloyd Huck Chair in Nano Bioengineering; and Heather Paris, associate director of the advising center and career services at Penn State Wilkes-Barre, have been selected to receive the 2026 Penn State Excellence in Advising Award.

WATCH: Cell ‘snowball’ may be answer to large-scale tissue engineering

Cell cultures — single layers of cells grown in a small dish — have enabled researchers to study biological growth, develop or test drugs and even discover what causes some diseases. Cell spheroids, 3D versions of cell cultures built using a process known as cell aggregation, are the next step in advancing this work, capable of more closely modeling real tissue.

Seth Bordenstein named a Fellow of the AAAS

Seth Bordenstein, professor of biology and entomology, the Dorothy Foehr Huck and J. Lloyd Huck Chair of Microbiome Sciences, and director of the Penn State One Health Microbiome Center, has been named a Fellow of the American Association for the Advancement of Science,