Collage for hero banner of microbes

One Health Microbiome Center

As one of the largest and most active organizations in the field, the internationally awarded One Health Microbiome Center has a mission to optimize, accelerate, and disseminate long-lasting applications and knowledge on the microbiome.

Microbiomes are communities of microorganisms (e.g., bacteria, fungi, viruses, archaea, and protozoa) that inhabit an environment, including plants, animals, soils, oceans, and our homes. As we peer into our bodies, half of the cells in a human are microbes, and the gene catalogue of these human-associated microbes dwarfs that of our own human genome by at least 100-fold. Members of the microbiome can range from helpful to harmful, but notably the vast majority do not cause disease. As a collective, microbial assemblages and their genomes have profound impacts on solutions related to agricultural production, human chronic diseases, and ecosystem stability, among others. As we break ground on understanding how these diverse communities impact life, it is clear that the new study of the microbiome is central to biological systems, education, and applications in a rapidly changing world.

The center deeply embodies my vision for growing interdisciplinary excellence

—Penn State President Neeli Bendapudi, November 2024

550

Members

$224M

Awarded Funding

42+

Departments

100

Country Collaborations

7

American Academy of Microbiology Fellows

2000+

Publications in a Five-Year Period

First Ph.D

In Microbiome Science

Pierce Prize

First Ever Awarded to a Center, Not an Individual

News

Flipping and reversing mini-proteins could improve disease treatment

For the microbe that gives rise to tuberculosis, a team of researchers from Penn State and The University of Minnesota Medical School found that a potential solution may be chemically changing the structure of a naturally occurring peptide — a building block of proteins — to make it a more stable and effective antimicrobial agent, while reducing potential toxicity to human cells.

Too many saturated fats may be more harmful than too many refined carbohydrates

In recent years, many media reports and social media influencers have emphasized the dangers of eating too many carbohydrates. Though a carbohydrate-heavy diet can be harmful, consuming too many fats may cause more health problems, according to a study in mice led by researchers in the Penn State Department of Nutritional Sciences.

Nominate the next Microbiome Medal Laureate

The Microbiome Medal honors scholars or a group of scholars who demonstrate excellence, acumen and ingenuity in research, mentorship and service to the global field of microbiome science. Members of the global microbiome research community at any stage of their career are encouraged to nominate a scientist or group of scientists who exemplify this mission of the Microbiome Medal.

Penn State students take top honors in video challenge on the value of research

A team of students working in Andrew Patterson's lab used their experience in research and storytelling to advocate for federally funded research and take top prizes in the Science Coalition’s 2025 Alyse Gray Parker Memorial Student Video Challenge