People
Jean-Paul Armache
Assistant Professor of of Biochemistry and Molecular Biology
The mechanisms and functions of ATP-dependent chromatin remodeling complexes and their place in gene regulation.
Stephen Benkovic
Evan Pugh University Professor and Eberly Chair in Chemistry
Philip Bevilacqua
Co-Director, Center for RNA Molecular Biology; Distinguished Professor of Chemistry and of Biochemistry and Molecular Biology
RNA folding in vivo and genome-wide; RNA regulation of gene expression; Ribozyme Mechanism; roles RNA may have played in the emergence of life on early earth
David Boehr
Associate Professor of Chemistry
The role of protein dynamics in enzyme function, coordination and regulation
Sung Hyun (Joseph) Cho
Co-Director, Cryo-Electron Microscopy Core Facility; Assistant Research Professor
Joshua Gross
Assistant Professor of Nutrition and Biobehavioral Health
Cellular- and transgenic mouse model-based approaches to investigate the molecular mechanisms of G protein-coupled receptor (GPCR) signaling and trafficking in the pathophysiological contexts of obesity, eating disorders, and metabolic disease.
Mark Hedglin
Assistant Professor of Chemistry; Assistant Professor of Biochemistry and Molecular Biology
Deciphering how efficient and faithful replication of the human genome is achieved within the highly-complex, dynamic, and reactive environment of the nucleus. Identifying pathways for genomic instability in humans, identifying novel oncogenic drug targets, developing better chemotherapeutic treatments for human cancers caused by genomic instability.
Wen Jiang
Faculty Director of the Cryo-Electron Microscopy Core Facility; Professor of Biochemistry & Molecular Biology
Joyce Jose
Associate Professor of Biochemistry & Molecular Biology
Virus-host interactions involved in the pathogenesis of alphaviruses and flaviviruses. Analysis of virus induced structures and cytoskeletal modifications in mammalian host and insect vector using high-resolution live cell imaging and electron microscopy. Viral determinants of neurotropism, encephalitis, transmission and persistence in BSL-3 pathogens.
Andrey Krasilnikov
Associate Professor of Biochemistry and Molecular Biology
Structural biology of RNA and RNA-protein complexes
Scott Lindner
Co-Director, Center for Malaria Research; Associate Professor of Biochemistry & Molecular Biology
RNA/protein complexes, translational control, and the specialized ribosomes of malaria parasites using sequencing, proteomics, and genetic approaches with a focus on the transmission stages of Plasmodium parasites between mammals and mosquitoes
Ibrahim Moustafa
Assistant Research Professor of Biochemistry and Molecular Biology
Process and analyze cryo-EM data to generate high-resolution 3D reconstructions using established software packages.
Katsuhiko Murakami
Director of the Center for Structural Biology; Professor of Biochemistry and Molecular Biology
Structural and Mechanistic Enzymology of Prokaryotic RNA Polymerases
B. Tracy Nixon
Professor of Biochemistry and Molecular Biology
Structural and functional basis of cellulose synthesis. Using Physcomitrella patens and other organisms as model systems, we are learning how plants make cellulose for building new cell wall. The studies use methods of molecular biology and cryoEM to characterize the enzyme as a monomer, and when it assembles into its larger 'Cellulose Synthase Complex '(CSC for short). The aim is to understand cellulose synthesis to explain fundamentals of cell wall biology in plants, and to enable manipulation of its synthesis for applications in fields of bioenergy and materials.
Denise Okafor
Huck Early Career Chair in Biophysics, Assistant Professor of Biochemistry and Molecular Biology
Structural mechanisms of signaling and regulation in protein complexes.
Scott Showalter
Professor of Chemistry; Professor of Biochemistry and Molecular Biology
Biophysical Chemistry applied to solution NMR spectroscopy of partially disordered proteins. NMR studies of protein dynamics coupled with computational and theoretical studies of the coupling between nuclear spin relaxation and molecular motion.
Song Tan
Director of the Center for Eukaryotic Gene Regulation; Professor of Biochemistry and Molecular Biology
Structural biology of eukaryotic gene regulation.
Emily Weinert
Professor of Biochemistry and Molecular Biology
The mechanisms by which bacteria sense and respond to the environment, as well as how these signaling proteins/pathways affect competition, host colonization, and pathogenesis.
Neela Yennawar
Director, Biomolecular Interactions Core Facility; Co-Director, X-Ray Crystallography and Scattering Core Facility; Research Professor
Biological calorimetry, protein characterization, molecular modeling, X-ray crystallography, and small-angle X-ray scattering.