Emily Weinert
Professor of Biochemistry and Molecular Biology
-
306 Althouse Lab
University Park, PA - eew5225@psu.edu
- 814-865-3719
Research Summary
The mechanisms by which bacteria sense and respond to the environment, as well as how these signaling proteins/pathways affect competition, host colonization, and pathogenesis.
Graduate Advisor
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- One Health Microbiome Center
- Center for Structural Biology
- Center for RNA Molecular Biology
Links
Most Recent Publications
Heme pocket modulates protein conformation and diguanylate cyclase activity of a tetrameric globin coupled sensor
Jacob R. Potter, Shannon Rivera, Paul G. Young, Dayna C. Patterson, Kevin E. Namitz, Neela Yennawar, James R. Kincaid, Yilin Liu, Emily E. Weinert, 2024, Journal of Inorganic Biochemistry
Oxygen-selective regulation of cyclic di-GMP synthesis by a globin coupled sensor with a shortened linking domain modulates Shewanella sp. ANA-3 biofilm
Ariel Schuelke-Sanchez, Neela H. Yennawar, Emily E. Weinert, 2024, Journal of Inorganic Biochemistry
Bile salt hydrolase catalyses formation of amine-conjugated bile acids.
Bipin Rimal, Stephanie Collins, Megan Granda, Ceylan Tanes, Imhoi Koo, E Rocha, Sumeet Solanka, M Granda, Nushrat Hoque, Sumeet Solanki, Nushrat Hoque, Emily Gentry, Emily Gentry, Tingting Yan, Imhoi Koo, Kristopher Krausz, Erin Reilly, Fuhua Hao, Dhimant Desai, Shantu Amin, Devendra Paudel, Vishal Singh, Edson Rocha, James Coleman, Tingting Yan, Min Kim, Yatrik Shah, Frank Gonzalez, Kyle Bittinger, John Vanden Heuvel, Joseph Zackular, Kristopher Krausz, A Patterson, Dhimant Desai, Shantu Amin, James Coleman, Yatrik Shah, Jordan Bisanz, Frank Gonzalez, John P. Vanden Heuvel, John Heuvel, Gary Wu, Babette Zemel, Pieter Dorrestein, Emily E. Weinert, Andrew Patterson, 2024, Nature on p. 859-863
Control of bacterial second messenger signaling and motility by heme-based direct oxygen-sensing proteins
Nushrat J. Hoque, Emily E. Weinert, 2023, Current Opinion in Microbiology
The Extracellular Electron Transport Pathway Reduces Copper for Sensing by the CopRS Two-Component System under Anaerobic Conditions in Listeria monocytogenes
A Rizk, G Komazin, Gloria Meredith, M Maybin, N Hoque, Hoque Nushrat, Emily Weinert, Timothy Meredith, 2023, Journal of Bacteriology on p. e00391-22
Strain-Specific Gifsy-1 Prophage Genes Are Determinants for Expression of the RNA Repair Operon during the SOS Response in Salmonella enterica Serovar Typhimurium
Jennifer E. Kurasz, Madison C. Crawford, Steffen Porwollik, Oliver Gregory, Katerina R. Tadlock, Eve C. Balding, Emily E. Weinert, Michael McClelland, Anna C. Karls, 2023, Journal of Bacteriology
Insights into the metabolism, signaling, and physiological effects of 2’,3’-cyclic nucleotide monophosphates in bacteria
Nick J. Marotta, Emily E. Weinert, 2023, Critical Reviews in Biochemistry and Molecular Biology
Spectrophotometric Method for the Quantification and Kinetic Evaluation of In Vitro c-di-GMP Hydrolysis in the Presence and Absence of Oxygen
Dayna C. Patterson, Emily E. Weinert, 2023, on p. 87-98
In Vitro Measurement of Gas-Dependent and Redox-Sensitive Diguanylate Cyclase Activity
Nushrat J. Hoque, Madison P. Helm, Emily E. Weinert, 2023, on p. 75-86
An O<sub>2</sub>-sensing diguanylate cyclase broadly affects the aerobic transcriptome in the phytopathogen Pectobacterium carotovorum
Florian J. Fekete, Nick J. Marotta, Xuanyu Liu, Emily E. Weinert, 2023, Frontiers in Microbiology
Most-Cited Papers
Oligomeric state affects oxygen dissociation and diguanylate cyclase activity of globin coupled sensors
Justin L. Burns, D. Douglas Deer, Emily E. Weinert, 2014, Molecular BioSystems on p. 2823-2826
Identification of ellagic acid rhamnoside as a bioactive component of a complex botanical extract with anti-biofilm activity
Benjamin M. Fontaine, Kate Nelson, James T. Lyles, Parth B. Jariwala, Jennifer M. García-Rodriguez, Cassandra L. Quave, Emily E. Weinert, 2017, Frontiers in Microbiology
Bile salt hydrolase catalyses formation of amine-conjugated bile acids.
Bipin Rimal, Stephanie Collins, Megan Granda, Ceylan Tanes, Imhoi Koo, E Rocha, Sumeet Solanka, M Granda, Nushrat Hoque, Sumeet Solanki, Nushrat Hoque, Emily Gentry, Emily Gentry, Tingting Yan, Imhoi Koo, Kristopher Krausz, Erin Reilly, Fuhua Hao, Dhimant Desai, Shantu Amin, Devendra Paudel, Vishal Singh, Edson Rocha, James Coleman, Tingting Yan, Min Kim, Yatrik Shah, Frank Gonzalez, Kyle Bittinger, John Vanden Heuvel, Joseph Zackular, Kristopher Krausz, A Patterson, Dhimant Desai, Shantu Amin, James Coleman, Yatrik Shah, Jordan Bisanz, Frank Gonzalez, John P. Vanden Heuvel, John Heuvel, Gary Wu, Babette Zemel, Pieter Dorrestein, Emily E. Weinert, Andrew Patterson, 2024, Nature on p. 859-863
Mechanism and Role of Globin-Coupled Sensor Signalling
Johnnie A. Walker, Shannon Rivera, Emily E. Weinert, 2017, on p. 133-169
RNase I regulates Escherichia coli 2<sup>0</sup>,3<sup>0</sup>-cyclic nucleotide monophosphate levels and biofilm formation
Benjamin M. Fontaine, Kevin S. Martin, Jennifer M. Garcia-Rodriguez, Claire Jung, Laura Briggs, Jessica E. Southwell, Xin Jia, Emily E. Weinert, 2018, Biochemical Journal on p. 1491-1506
An O<sub>2</sub>-sensing stressosome from a Gram-negative bacterium
Xin Jia, Jian Bo Wang, Shannon Rivera, Duc Duong, Emily E. Weinert, 2016, Nature Communications
A facile and sensitive method for quantification of cyclic nucleotide monophosphates in mammalian organs: Basal levels of eight cNMPs and identification of 2',3'-cIMP
Xin Jia, Benjamin M. Fontaine, Fred Strobel, Emily E. Weinert, 2014, Biomolecules on p. 1070-1092
Structural Insights into Oxygen-Dependent Signal Transduction within Globin Coupled Sensors
Shannon Rivera, Paul G. Young, Eric D. Hoffer, Gregory E. Vansuch, Carmen L. Metzler, Christine M. Dunham, Emily E. Weinert, 2018, Inorganic Chemistry on p. 14386-14395
Oxygen and Bis(3',5')-cyclic Dimeric Guanosine Monophosphate Binding Control Oligomerization State Equilibria of Diguanylate Cyclase-Containing Globin Coupled Sensors
Justin L. Burns, Shannon Rivera, D. Douglas Deer, Shawnna C. Joynt, David Dvorak, Emily E. Weinert, 2016, Biochemistry on p. 6642-6651
Exploring the Links between Nucleotide Signaling and Quorum Sensing Pathways in Regulating Bacterial Virulence
Benjamin M. Fontaine, Yashasvika Duggal, Emily E. Weinert, 2018, ACS Infectious Diseases on p. 1645-1655
News Articles Featuring Emily Weinert
Feb 28, 2024
New role for bacterial enzyme in gut metabolism revealed
Bile acids long have been known to play a role in human metabolism. Synthesized from cholesterol in the liver, bile acids are involved in digestive processes, particularly in absorbing fat.
Full Article