Stephen Benkovic

Evan Pugh University Professor and Eberly Chair in Chemistry

Stephen Benkovic

Huck Affiliations

Links

Publication Tags

Enzymes Proteins Purine Catalysis Tetrahydrofolate Dehydrogenase Dna Hydrides Isotopes Boronic Acids Mitochondria Replication Protein A Proliferating Cell Nuclear Antigen Kinetics Temperature Escherichia Coli Nucleotides Computer Simulation Biosynthetic Pathways Biosynthesis Cells Purines Microtubules Molecular Dynamics Protein Engineering Amino Acids

Most Recent Papers

Rapid generation of incremental truncation libraries for protein engineering using α-phosphothioate nucleotides

Stefan Lutz, Marc Ostermeier, Stephen J. Benkovic, 2021, Nucleic Acids Research

Human de novo purine biosynthesis

Vidhi Pareek, Anthony M. Pedley, Stephen J. Benkovic, 2021, Critical Reviews in Biochemistry and Molecular Biology on p. 1-16

PCNA Monoubiquitination Is Regulated by Diffusion of Rad6/Rad18 Complexes along RPA Filaments

Mingjie Li, Bhaswati Sengupta, Stephen J. Benkovic, Tae Hee Lee, Mark Hedglin, 2020, Biochemistry on p. 4694-4702

Hypoxia drives the assembly of the multienzyme purinosome complex

Cyrielle Doigneaux, Anthony M. Pedley, Ishna N. Mistry, Monika Papayova, Stephen J. Benkovic, Ali Tavassoli, 2020, Journal of Biological Chemistry on p. 9551-9566

Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells

Vidhi Pareek, Hua Tian, Nicholas Winograd, Stephen J. Benkovic, 2020, Science on p. 283-290

Thomas Bruice (1925-2019)

Stephen J. Benkovic, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 22418-22419

Recognition of a Key Anchor Residue by a Conserved Hydrophobic Pocket Ensures Subunit Interface Integrity in DNA Clamps

Senthil K. Perumal, Xiaojun Xu, Chunli Yan, Ivaylo Ivanov, Stephen J. Benkovic, 2019, Journal of Molecular Biology on p. 2493-2510

Mapping Post-Translational Modifications of de Novo Purine Biosynthetic Enzymes: Implications for Pathway Regulation.

C Liu, G Knudsen, Anthony Pedley, J He, J Johnson, T Yaron, L Cantley, S Benkovic, 2019, Journal of Proteome Research on p. 2078-2087

Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria

Chung Yu Chan, Anthony M. Pedley, Doory Kim, Chenglong Xia, Xiaowei Zhuang, Stephen Benkovic, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 13009-13014

Role of HSP90 in the Regulation of de Novo Purine Biosynthesis

Anthony M. Pedley, Georgios I. Karras, Xin Zhang, Susan Lindquist, Stephen Benkovic, 2018, Biochemistry on p. 3217-3221

Most-Cited Papers

A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis

Gira Bhabha, Jeeyeon Lee, Damian C. Ekiert, Jongsik Gam, Ian A. Wilson, H. Jane Dyson, Stephen J. Benkovic, Peter E. Wright, 2011, Science on p. 234-238

Controlling cell-cell interactions using surface acoustic waves

Feng Guo, Peng Li, Jarrod B. French, Zhangming Mao, Hong Zhao, Sixing Li, Nitesh Nama, James R. Fick, Stephen J. Benkovic, Tony Jun Huang, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. 43-48

Boron-containing inhibitors of synthetases

Stephen J. Baker, John W. Tomsho, Stephen J. Benkovic, 2011, Chemical Society Reviews on p. 4279-4285

Flexibility, diversity, and cooperativity

Gordon G. Hammes, Stephen J. Benkovic, Sharon Hammes-Schiffer, 2011, Biochemistry on p. 10422-10430

A New View into the Regulation of Purine Metabolism

Anthony M. Pedley, Stephen J. Benkovic, 2017, Trends in Biochemical Sciences on p. 141-154

Evolution of cyclic peptide protease inhibitors

Travis S. Young, Douglas D. Young, Insha Ahmad, John M. Louis, Stephen J. Benkovic, Peter G. Schultz, 2011, Proceedings of the National Academy of Sciences of the United States of America on p. 11052-11056

Perspectives on electrostatics and conformational motions in enzyme catalysis

Philip Hanoian, C. Tony Liu, Sharon Hammes-Schiffer, Stephen Benkovic, 2015, Accounts of Chemical Research on p. 482-489

Spatial colocalization and functional link of purinosomes with mitochondria

Jarrod B. French, Sara A. Jones, Huayun Deng, Anthony M. Pedley, Doory Kim, Chung Yu Chan, Haibei Hu, Raymond J. Pugh, Hong Zhao, Youxin Zhang, Tony Jun Huang, Ye Fang, Xiaowei Zhuang, Stephen J. Benkovic, 2016, Science on p. 733-737

Ring structure and aromatic substituent effects on the p K <sub>a</sub> of the benzoxaborole pharmacophore

John W. Tomsho, Arnab Pal, Dennis G. Hall, Stephen J. Benkovic, 2012, ACS Medicinal Chemistry Letters on p. 48-52

Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction

Vanja Stojković, Laura L. Perissinotti, Daniel Willmer, Stephen J. Benkovic, Amnon Kohen, 2012, Journal of the American Chemical Society on p. 1738-1745