Stephen Benkovic
Evan Pugh University Professor and Eberly Chair in Chemistry
-
414 Wartik
University Park, PA - sjb1@psu.edu
- 814-865-2882
Publication Tags
Enzymes Proteins Purine Catalysis Tetrahydrofolate Dehydrogenase Dna Hydrides Isotopes Boronic Acids Mitochondria Replication Protein A Proliferating Cell Nuclear Antigen Kinetics Temperature Escherichia Coli Nucleotides Computer Simulation Biosynthetic Pathways Biosynthesis Cells Purines Microtubules Molecular Dynamics Protein Engineering Amino AcidsMost Recent Papers
Rapid generation of incremental truncation libraries for protein engineering using α-phosphothioate nucleotides
Stefan Lutz, Marc Ostermeier, Stephen J. Benkovic, 2021, Nucleic Acids Research
Human de novo purine biosynthesis
Vidhi Pareek, Anthony M. Pedley, Stephen J. Benkovic, 2021, Critical Reviews in Biochemistry and Molecular Biology on p. 1-16
PCNA Monoubiquitination Is Regulated by Diffusion of Rad6/Rad18 Complexes along RPA Filaments
Mingjie Li, Bhaswati Sengupta, Stephen J. Benkovic, Tae Hee Lee, Mark Hedglin, 2020, Biochemistry on p. 4694-4702
Hypoxia drives the assembly of the multienzyme purinosome complex
Cyrielle Doigneaux, Anthony M. Pedley, Ishna N. Mistry, Monika Papayova, Stephen J. Benkovic, Ali Tavassoli, 2020, Journal of Biological Chemistry on p. 9551-9566
Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells
Vidhi Pareek, Hua Tian, Nicholas Winograd, Stephen J. Benkovic, 2020, Science on p. 283-290
Thomas Bruice (1925-2019)
Stephen J. Benkovic, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 22418-22419
Recognition of a Key Anchor Residue by a Conserved Hydrophobic Pocket Ensures Subunit Interface Integrity in DNA Clamps
Senthil K. Perumal, Xiaojun Xu, Chunli Yan, Ivaylo Ivanov, Stephen J. Benkovic, 2019, Journal of Molecular Biology on p. 2493-2510
Mapping Post-Translational Modifications of de Novo Purine Biosynthetic Enzymes: Implications for Pathway Regulation.
C Liu, G Knudsen, Anthony Pedley, J He, J Johnson, T Yaron, L Cantley, S Benkovic, 2019, Journal of Proteome Research on p. 2078-2087
Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria
Chung Yu Chan, Anthony M. Pedley, Doory Kim, Chenglong Xia, Xiaowei Zhuang, Stephen Benkovic, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 13009-13014
Role of HSP90 in the Regulation of de Novo Purine Biosynthesis
Anthony M. Pedley, Georgios I. Karras, Xin Zhang, Susan Lindquist, Stephen Benkovic, 2018, Biochemistry on p. 3217-3221
Most-Cited Papers
A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis
Gira Bhabha, Jeeyeon Lee, Damian C. Ekiert, Jongsik Gam, Ian A. Wilson, H. Jane Dyson, Stephen J. Benkovic, Peter E. Wright, 2011, Science on p. 234-238
Controlling cell-cell interactions using surface acoustic waves
Feng Guo, Peng Li, Jarrod B. French, Zhangming Mao, Hong Zhao, Sixing Li, Nitesh Nama, James R. Fick, Stephen J. Benkovic, Tony Jun Huang, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. 43-48
Boron-containing inhibitors of synthetases
Stephen J. Baker, John W. Tomsho, Stephen J. Benkovic, 2011, Chemical Society Reviews on p. 4279-4285
Flexibility, diversity, and cooperativity
Gordon G. Hammes, Stephen J. Benkovic, Sharon Hammes-Schiffer, 2011, Biochemistry on p. 10422-10430
A New View into the Regulation of Purine Metabolism
Anthony M. Pedley, Stephen J. Benkovic, 2017, Trends in Biochemical Sciences on p. 141-154
Evolution of cyclic peptide protease inhibitors
Travis S. Young, Douglas D. Young, Insha Ahmad, John M. Louis, Stephen J. Benkovic, Peter G. Schultz, 2011, Proceedings of the National Academy of Sciences of the United States of America on p. 11052-11056
Perspectives on electrostatics and conformational motions in enzyme catalysis
Philip Hanoian, C. Tony Liu, Sharon Hammes-Schiffer, Stephen Benkovic, 2015, Accounts of Chemical Research on p. 482-489
Spatial colocalization and functional link of purinosomes with mitochondria
Jarrod B. French, Sara A. Jones, Huayun Deng, Anthony M. Pedley, Doory Kim, Chung Yu Chan, Haibei Hu, Raymond J. Pugh, Hong Zhao, Youxin Zhang, Tony Jun Huang, Ye Fang, Xiaowei Zhuang, Stephen J. Benkovic, 2016, Science on p. 733-737
Ring structure and aromatic substituent effects on the p K <sub>a</sub> of the benzoxaborole pharmacophore
John W. Tomsho, Arnab Pal, Dennis G. Hall, Stephen J. Benkovic, 2012, ACS Medicinal Chemistry Letters on p. 48-52
Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction
Vanja Stojković, Laura L. Perissinotti, Daniel Willmer, Stephen J. Benkovic, Amnon Kohen, 2012, Journal of the American Chemical Society on p. 1738-1745