Stephen Benkovic
Evan Pugh University Professor and Eberly Chair in Chemistry
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414 Wartik
University Park, PA - sjb1@psu.edu
- 814-865-2882
Publication Tags
Enzymes Proteins Dna Purine Catalysis Proliferating Cell Nuclear Antigen Tetrahydrofolate Dehydrogenase Hydrides Isotopes Boronic Acids Mitochondria Replication Protein A Neurons Single Stranded Dna Kinetics Temperature Escherichia Coli Biosynthetic Pathways Substrates Purines Cracks Computer Simulation Biosynthesis Nucleotides MicrotubulesMost Recent Papers
Rapid generation of incremental truncation libraries for protein engineering using α-phosphothioate nucleotides
Stefan Lutz, Marc Ostermeier, Stephen J. Benkovic, 2021, Nucleic Acids Research
PCNA Monoubiquitination Is Regulated by Diffusion of Rad6/Rad18 Complexes along RPA Filaments
Mingjie Li, Bhaswati Sengupta, Stephen J. Benkovic, Tae Hee Lee, Mark Hedglin, 2020, Biochemistry on p. 4694-4702
Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria
Chung Yu Chan, Anthony M. Pedley, Doory Kim, Chenglong Xia, Xiaowei Zhuang, Stephen Benkovic, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 13009-13014
Role of HSP90 in the Regulation of de Novo Purine Biosynthesis
Anthony M. Pedley, Georgios I. Karras, Xin Zhang, Susan Lindquist, Stephen Benkovic, 2018, Biochemistry on p. 3217-3221
Expression of the purine biosynthetic enzyme phosphoribosyl formylglycinamidine synthase in neurons
Colleen Mangold, Pamela Yao, Mei Du, Willard Freeman, Stephen Benkovic, Moriah Szpara, 2018, Journal of Neurochemistry on p. 723--735
Substrate-driven chemotactic assembly in an enzyme cascade
Xi Zhao, Henri Palacci, Vinita Yadav, Michelle Marie Spiering, Michael K. Gilson, Peter J. Butler, Henry Hess, Stephen Benkovic, Ayusman Sen, 2018, Nature Chemistry on p. 311-317
Detecting purinosome metabolon formation with fluorescence microscopy
Anthony M. Pedley, Stephen J. Benkovic, 2018, on p. 279-289
Understanding DNA replication by the bacteriophage T4 replisome
Stephen J. Benkovic, Michelle M. Spiering, 2017, Journal of Biological Chemistry on p. 18434-18442
Monitoring the Retention of Human Proliferating Cell Nuclear Antigen at Primer/Template Junctions by Proteins That Bind Single-Stranded DNA
Mark Hedglin, Mahesh Aitha, Stephen J. Benkovic, 2017, Biochemistry on p. 3415-3421
Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands
Mark Hedglin, Stephen J. Benkovic, 2017, Chemical Reviews on p. 7857-7877
Most-Cited Papers
A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis
Gira Bhabha, Jeeyeon Lee, Damian C. Ekiert, Jongsik Gam, Ian A. Wilson, H. Jane Dyson, Stephen J. Benkovic, Peter E. Wright, 2011, Science on p. 234-238
Controlling cell-cell interactions using surface acoustic waves
Feng Guo, Peng Li, Jarrod B. French, Zhangming Mao, Hong Zhao, Sixing Li, Nitesh Nama, James R. Fick, Stephen J. Benkovic, Tony Jun Huang, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. 43-48
Boron-containing inhibitors of synthetases
Stephen J. Baker, John W. Tomsho, Stephen J. Benkovic, 2011, Chemical Society Reviews on p. 4279-4285
Flexibility, diversity, and cooperativity
Gordon G. Hammes, Stephen J. Benkovic, Sharon Hammes-Schiffer, 2011, Biochemistry on p. 10422-10430
A New View into the Regulation of Purine Metabolism
Anthony M. Pedley, Stephen J. Benkovic, 2017, Trends in Biochemical Sciences on p. 141-154
Evolution of cyclic peptide protease inhibitors
Travis S. Young, Douglas D. Young, Insha Ahmad, John M. Louis, Stephen J. Benkovic, Peter G. Schultz, 2011, Proceedings of the National Academy of Sciences of the United States of America on p. 11052-11056
Spatial colocalization and functional link of purinosomes with mitochondria
Jarrod B. French, Sara A. Jones, Huayun Deng, Anthony M. Pedley, Doory Kim, Chung Yu Chan, Haibei Hu, Raymond J. Pugh, Hong Zhao, Youxin Zhang, Tony Jun Huang, Ye Fang, Xiaowei Zhuang, Stephen J. Benkovic, 2016, Science on p. 733-737
Perspectives on electrostatics and conformational motions in enzyme catalysis
Philip Hanoian, C. Tony Liu, Sharon Hammes-Schiffer, Stephen Benkovic, 2015, Accounts of Chemical Research on p. 482-489
Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction
Vanja Stojković, Laura L. Perissinotti, Daniel Willmer, Stephen J. Benkovic, Amnon Kohen, 2012, Journal of the American Chemical Society on p. 1738-1745
Ring structure and aromatic substituent effects on the p K <sub>a</sub> of the benzoxaborole pharmacophore
John W. Tomsho, Arnab Pal, Dennis G. Hall, Stephen J. Benkovic, 2012, ACS Medicinal Chemistry Letters on p. 48-52