Stephen Benkovic
Evan Pugh University Professor and Eberly Chair in Chemistry
-
414 Wartik
University Park, PA - sjb1@psu.edu
- 814-865-2882
Publication Tags
Purine Enzymes Biosynthesis Protein Pumps Isotopes Nucleotides Proteins Boronic Acids Metabolic Hydrides Tetrahydrofolate Dehydrogenase Dna Cells Catalysis Metabolomics Benzoxaborole Purines Dihydrofolates Mass Spectrometry Hydride Mass Spectroscopy Synthesis Biotechnology Multienzyme ComplexesMost Recent Publications
Multienzyme interactions of the de novo purine biosynthetic protein PAICS facilitate purinosome formation and metabolic channeling
Jingxuan He, Ling Nan Zou, Vidhi Pareek, Stephen J. Benkovic, 2022, Journal of Biological Chemistry
Purine biosynthetic enzymes assemble into liquid-like condensates dependent on the activity of chaperone protein HSP90
Anthony M. Pedley, Jack P. Boylan, Chung Yu Chan, Erin L. Kennedy, Minjoung Kyoung, Stephen J. Benkovic, 2022, Journal of Biological Chemistry
The Purinosome: A Case Study for a Mammalian Metabolon
Anthony M. Pedley, Vidhi Pareek, Stephen J. Benkovic, 2022, Annual Review of Biochemistry on p. 89-106
Metabolic channeling: predictions, deductions, and evidence
Vidhi Pareek, Zhou Sha, Jingxuan He, S Benkovic, 2021, Molecular Cell on p. 3775-3785
Replication: DNA replication fork, bacterial
M. M. Spiering, S. J. Benkovic, 2021, on p. 49-53
From Bioorganic Models to Cells
Stephen J. Benkovic, 2021, Annual Review of Biochemistry on p. 57-76
Rapid generation of incremental truncation libraries for protein engineering using α-phosphothioate nucleotides
Stefan Lutz, Marc Ostermeier, Stephen J. Benkovic, 2021, Nucleic Acids Research
Human de novo purine biosynthesis
Vidhi Pareek, Anthony M. Pedley, Stephen J. Benkovic, 2021, Critical Reviews in Biochemistry and Molecular Biology on p. 1-16
Hypoxia drives the assembly of the multienzyme purinosome complex
Cyrielle Doigneaux, Anthony M. Pedley, Ishna N. Mistry, Monika Papayova, Stephen J. Benkovic, Ali Tavassoli, 2020, Journal of Biological Chemistry on p. 9551-9566
Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells
Vidhi Pareek, Hua Tian, Nicholas Winograd, Stephen J. Benkovic, 2020, Science on p. 283-290
Most-Cited Papers
Controlling cell-cell interactions using surface acoustic waves
Feng Guo, Peng Li, Jarrod B. French, Zhangming Mao, Hong Zhao, Sixing Li, Nitesh Nama, James R. Fick, Stephen J. Benkovic, Tony Jun Huang, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. 43-48
A New View into the Regulation of Purine Metabolism: The Purinosome
Anthony M. Pedley, Stephen J. Benkovic, 2017, Trends in Biochemical Sciences on p. 141-154
Spatial colocalization and functional link of purinosomes with mitochondria
Jarrod B. French, Sara A. Jones, Huayun Deng, Anthony M. Pedley, Doory Kim, Chung Yu Chan, Haibei Hu, Raymond J. Pugh, Hong Zhao, Youxin Zhang, Tony Jun Huang, Ye Fang, Xiaowei Zhuang, Stephen J. Benkovic, 2016, Science on p. 733-737
Perspectives on electrostatics and conformational motions in enzyme catalysis
Philip Hanoian, C. Tony Liu, Sharon Hammes-Schiffer, Stephen Benkovic, 2015, Accounts of Chemical Research on p. 482-489
Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells
Vidhi Pareek, Hua Tian, Nicholas Winograd, Stephen J. Benkovic, 2020, Science on p. 283-290
Ring structure and aromatic substituent effects on the p K <sub>a</sub> of the benzoxaborole pharmacophore
John W. Tomsho, Arnab Pal, Dennis G. Hall, Stephen J. Benkovic, 2012, ACS Medicinal Chemistry Letters on p. 48-52
Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction
Vanja Stojković, Laura L. Perissinotti, Daniel Willmer, Stephen J. Benkovic, Amnon Kohen, 2012, Journal of the American Chemical Society on p. 1738-1745
The unique chemistry of benzoxaboroles: Current and emerging applications in biotechnology and therapeutic treatments
C. Tony Liu, John W. Tomsho, Stephen J. Benkovic, 2014, Bioorganic and Medicinal Chemistry on p. 4462-4473
Substrate-driven chemotactic assembly in an enzyme cascade
Xi Zhao, Henri Palacci, Vinita Yadav, Michelle M. Spiering, Michael K. Gilson, Peter J. Butler, Henry Hess, Stephen J. Benkovic, Ayusman Sen, 2018, Nature Chemistry on p. 311-317
DNA polymerase as a molecular motor and pump
Samudra Sengupta, Michelle M. Spiering, Krishna K. Dey, Wentao Duan, Debabrata Patra, Peter J. Butler, R. Dean Astumian, Stephen J. Benkovic, Ayusman Sen, 2014, ACS Nano on p. 2410-2418
News Articles Featuring Stephen Benkovic
Sep 02, 2022
Metabolomics Core Facility continues to expand while pushing scientific bounds
Established nearly a decade ago, Penn State’s Metabolomics Core Facility is housed in the Huck Institutes of the Life Sciences on the University Park campus.
Full Article
Feb 07, 2022
Benkovics support pioneering research in chemistry and the life sciences
You might think of Patricia and Stephen Benkovic as Penn State’s “first couple of chemistry,” considering all the pioneering contributions they’ve made at the University in their shared discipline over a span of more than five decades. Now the pair are giving back to their research community in an exciting new way, hoping to inspire the next generation of scientists to carry the torch of innovation and discovery to even greater heights.
Full Article
May 07, 2021
Pioneering chemist Stephen Benkovic elected Foreign Member of Royal Society 6
Stephen Benkovic, Evan Pugh Professor and Holder of the Eberly Family Chair in Chemistry at Penn State, has been elected a Foreign Member of the Royal Society, the national academy of science in the United Kingdom. The society, founded in 1660, aims to recognize, promote and support excellence in science and to encourage the development and use of science for the benefit of humanity.
Full Article