Stephen Benkovic
Evan Pugh University Professor and Eberly Chair in Chemistry
-
414 Wartik
University Park, PA - sjb1@psu.edu
- 814-865-2882
Most Recent Publications
Enhancing transcription–replication conflict targets ecDNA-positive cancers
Jun Tang, Natasha E. Weiser, Guiping Wang, Sudhir Chowdhry, Ellis J. Curtis, Yanding Zhao, Ivy Tsz Lo Wong, Georgi K. Marinov, Rui Li, Philip Hanoian, Edison Tse, Salvador Garcia Mojica, Ryan Hansen, Joshua Plum, Auzon Steffy, Snezana Milutinovic, S. Todd Meyer, Jens Luebeck, Yanbo Wang, Shu Zhang, Nicolas Altemose, Christina Curtis, William J. Greenleaf, Vineet Bafna, Stephen J. Benkovic, Anthony B. Pinkerton, Shailaja Kasibhatla, Christian A. Hassig, Paul S. Mischel, Howard Y. Chang, 2024, Nature on p. 210-218
Purinosomes spatially co-localize with mitochondrial transporters
Zhou Sha, Stephen J. Benkovic, 2024, Journal of Biological Chemistry
Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models
Qian Ma, Qiuhua Yang, Jiean Xu, Hunter G. Sellers, Zach L. Brown, Zhiping Liu, Zsuzsanna Bordan, Xiaofan Shi, Dingwei Zhao, Yongfeng Cai, Vidhi Pareek, Chunxiang Zhang, Guangyu Wu, Zheng Dong, Alexander D. Verin, Lin Gan, Quansheng Du, Stephen J. Benkovic, Suowen Xu, John M. Asara, Issam Ben-Sahra, Scott Barman, Yunchao Su, David J.R. Fulton, Yuqing Huo, 2023, European Heart Journal on p. 1265-1279
ATIC-Associated De Novo Purine Synthesis Is Critically Involved in Proliferative Arterial Disease
Qian Ma, Qiuhua Yang, Jiean Xu, Xiaoyu Zhang, David Kim, Zhiping Liu, Qingen Da, Xiaoxiao Mao, Yaqi Zhou, Yongfeng Cai, Vidhi Pareek, Ha Won Kim, Guangyu Wu, Zheng Dong, Wen Liang Song, Lin Gan, Chunxiang Zhang, Mei Hong, Stephen J. Benkovic, Neal L. Weintraub, David Fulton, John M. Asara, Issam Ben-Sahra, Yuqing Huo, 2022, Circulation on p. 1444-1460
Purine biosynthetic enzymes assemble into liquid-like condensates dependent on the activity of chaperone protein HSP90
Anthony M. Pedley, Jack P. Boylan, Chung Yu Chan, Erin L. Kennedy, Minjoung Kyoung, Stephen J. Benkovic, 2022, Journal of Biological Chemistry
Multienzyme interactions of the de novo purine biosynthetic protein PAICS facilitate purinosome formation and metabolic channeling
Jingxuan He, Ling Nan Zou, Vidhi Pareek, Stephen J. Benkovic, 2022, Journal of Biological Chemistry
The Purinosome: A Case Study for a Mammalian Metabolon
Anthony M. Pedley, Vidhi Pareek, Stephen J. Benkovic, 2022, Annual Review of Biochemistry on p. 89-106
Metabolic channeling: predictions, deductions, and evidence
Vidhi Pareek, Zhou Sha, Jingxuan He, S Benkovic, 2021, Molecular Cell on p. 3775-3785
Replication: DNA replication fork, bacterial
M. M. Spiering, S. J. Benkovic, 2021, on p. 49-53
From Bioorganic Models to Cells
Stephen J. Benkovic, 2021, Annual Review of Biochemistry on p. 57-76
Most-Cited Papers
A New View into the Regulation of Purine Metabolism: The Purinosome
Anthony M. Pedley, Stephen J. Benkovic, 2017, Trends in Biochemical Sciences on p. 141-154
Controlling cell-cell interactions using surface acoustic waves
Feng Guo, Peng Li, Jarrod B. French, Zhangming Mao, Hong Zhao, Sixing Li, Nitesh Nama, James R. Fick, Stephen J. Benkovic, Tony Jun Huang, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. 43-48
Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells
Vidhi Pareek, Hua Tian, Nicholas Winograd, Stephen J. Benkovic, 2020, Science on p. 283-290
Spatial colocalization and functional link of purinosomes with mitochondria
Jarrod B. French, Sara A. Jones, Huayun Deng, Anthony M. Pedley, Doory Kim, Chung Yu Chan, Haibei Hu, Raymond J. Pugh, Hong Zhao, Youxin Zhang, Tony Jun Huang, Ye Fang, Xiaowei Zhuang, Stephen J. Benkovic, 2016, Science on p. 733-737
Perspectives on electrostatics and conformational motions in enzyme catalysis
Philip Hanoian, C. Tony Liu, Sharon Hammes-Schiffer, Stephen Benkovic, 2015, Accounts of Chemical Research on p. 482-489
Substrate-driven chemotactic assembly in an enzyme cascade
Xi Zhao, Henri Palacci, Vinita Yadav, Michelle M. Spiering, Michael Gilson, Peter Butler, Henry Hess, Stephen J. Benkovic, Ayusman Sen, 2018, Nature Chemistry on p. 311--317
Quantitative analysis of purine nucleotides indicates that purinosomes increase de Novo purine biosynthesis
Hong Zhao, Christopher R. Chiaro, Limin Zhang, Philip B. Smith, Chung Yu Chan, Anthony M. Pedley, Raymond J. Pugh, Jarrod B. French, Andrew D. Patterson, Stephen J. Benkovic, 2015, Journal of Biological Chemistry on p. 6705-6713
Regulation of Rad6/Rad18 Activity during DNA Damage Tolerance
Mark Hedglin, Stephen J. Benkovic, 2015, Annual Review of Biophysics and Biomolecular Structure on p. 207-228
Human de novo purine biosynthesis
Vidhi Pareek, Anthony M. Pedley, Stephen J. Benkovic, 2021, Critical Reviews in Biochemistry and Molecular Biology on p. 1-16
Purinosome formation as a function of the cell cycle
Chung Yu Chan, Hong Zhao, Raymond J. Pugh, Anthony M. Pedley, Jarrod French, Sara A. Jones, Xiaowei Zhuang, Hyder Jinnah, Tony Jun Huan, Stephen J. Benkovic, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. 1368-1373
News Articles Featuring Stephen Benkovic
Jan 07, 2025
Alley awarded National Medal of Science, highest honor US bestows on scientists
Richard Alley, Evan Pugh University Professor of Geosciences at Penn State, was awarded the National Medal of Science at a White House ceremony on Jan. 3.
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Feb 15, 2024
Committee advances plan to rename Chemistry Building as 'Benkovic Building'
The Chemistry Building at the University Park campus will be renamed in honor of the careerlong scholarly impact of Stephen Benkovic, Atherton Professor of Chemistry
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Jan 22, 2024
Engineering professor named National Academy of Inventors fellow
The National Academy of Inventors (NAI) named Qiming Zhang, distinguished professor of electrical engineering in the College of Engineering, a fellow
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Jul 06, 2023
Penn State chemist Stephen Benkovic named Atherton Professor
Stephen Benkovic, Evan Pugh Professor and Holder of the Eberly Family Chair in Chemistry at Penn State, has been honored by Penn State with the title of Atherton Professor.
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Feb 23, 2023
Nobel Prize-winning Penn State alumnus Paul Berg dies
Penn State alumnus Paul Berg, who received the 1980 Nobel Prize in chemistry, died Feb. 15 at his home in Stanford, California, surrounded by loved ones. He was 96.
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Dec 08, 2022
National Academy of Inventors names three Penn Staters as 2022 fellows
The National Academy of Inventors (NAI) named three Penn State College of Engineering faculty members as fellows, the highest professional distinction awarded to academic inventors.
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Sep 02, 2022
Metabolomics Core Facility continues to expand while pushing scientific bounds
Established nearly a decade ago, Penn State’s Metabolomics Core Facility is housed in the Huck Institutes of the Life Sciences on the University Park campus.
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Feb 07, 2022
Benkovics support pioneering research in chemistry and the life sciences
You might think of Patricia and Stephen Benkovic as Penn State’s “first couple of chemistry,” considering all the pioneering contributions they’ve made at the University in their shared discipline over a span of more than five decades. Now the pair are giving back to their research community in an exciting new way, hoping to inspire the next generation of scientists to carry the torch of innovation and discovery to even greater heights.
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May 07, 2021
Pioneering chemist Stephen Benkovic elected Foreign Member of Royal Society 6
Stephen Benkovic, Evan Pugh Professor and Holder of the Eberly Family Chair in Chemistry at Penn State, has been elected a Foreign Member of the Royal Society, the national academy of science in the United Kingdom. The society, founded in 1660, aims to recognize, promote and support excellence in science and to encourage the development and use of science for the benefit of humanity.
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