Stephen Benkovic

Evan Pugh University Professor and Eberly Chair in Chemistry

Stephen Benkovic

Huck Affiliations


Publication Tags

Purine Enzymes Dna Proteins Biosynthesis Pumps Isotopes Boronic Acids Hydrides Tetrahydrofolate Dehydrogenase Nucleotides Proliferating Cell Nuclear Antigen Protein Catalysis Replication Protein A Hydride Benzoxaborole Biotechnology Dihydrofolates Temperature Modification Kinetics Multienzyme Complexes Mitochondria Simulation

Most Recent Papers

Metabolic channeling

Vidhi Pareek, Zhou Sha, Jingxuan He, Ned S. Wingreen, Stephen J. Benkovic, 2021, Molecular Cell on p. 3775-3785

From Bioorganic Models to Cells

Stephen J. Benkovic, 2021, Annual Review of Biochemistry on p. 57-76

Rapid generation of incremental truncation libraries for protein engineering using α-phosphothioate nucleotides

Stefan Lutz, Marc Ostermeier, Stephen J. Benkovic, 2021, Nucleic Acids Research

Human de novo purine biosynthesis

Vidhi Pareek, Anthony M. Pedley, Stephen J. Benkovic, 2021, Critical Reviews in Biochemistry and Molecular Biology on p. 1-16

PCNA Monoubiquitination Is Regulated by Diffusion of Rad6/Rad18 Complexes along RPA Filaments

Mingjie Li, Bhaswati Sengupta, Stephen J. Benkovic, Tae Hee Lee, Mark Hedglin, 2020, Biochemistry on p. 4694-4702

Hypoxia drives the assembly of the multienzyme purinosome complex

Cyrielle Doigneaux, Anthony M. Pedley, Ishna N. Mistry, Monika Papayova, Stephen J. Benkovic, Ali Tavassoli, 2020, Journal of Biological Chemistry on p. 9551-9566

Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells

Vidhi Pareek, Hua Tian, Nicholas Winograd, Stephen J. Benkovic, 2020, Science on p. 283-290

Thomas Bruice (1925-2019)

Stephen J. Benkovic, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 22418-22419

Recognition of a Key Anchor Residue by a Conserved Hydrophobic Pocket Ensures Subunit Interface Integrity in DNA Clamps

Senthil K. Perumal, Xiaojun Xu, Chunli Yan, Ivaylo Ivanov, Stephen J. Benkovic, 2019, Journal of Molecular Biology on p. 2493-2510

Mapping Post-Translational Modifications of de Novo Purine Biosynthetic Enzymes: Implications for Pathway Regulation.

Chunliang Liu, Giselle M. Knudsen, Anthony M. Pedley, Jingxuan He, Jared L. Johnson, Tomer M. Yaron, Lewis C. Cantley, Stephen J. Benkovic, 2019, Journal of Proteome Research on p. 2078-2087

Most-Cited Papers

Controlling cell-cell interactions using surface acoustic waves

Feng Guo, Peng Li, Jarrod B. French, Zhangming Mao, Hong Zhao, Sixing Li, Nitesh Nama, James R. Fick, Stephen J. Benkovic, Tony Jun Huang, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. 43-48

A New View into the Regulation of Purine Metabolism

Anthony M. Pedley, Stephen J. Benkovic, 2017, Trends in Biochemical Sciences on p. 141-154

Spatial colocalization and functional link of purinosomes with mitochondria

Jarrod B. French, Sara A. Jones, Huayun Deng, Anthony M. Pedley, Doory Kim, Chung Yu Chan, Haibei Hu, Raymond J. Pugh, Hong Zhao, Youxin Zhang, Tony Jun Huang, Ye Fang, Xiaowei Zhuang, Stephen J. Benkovic, 2016, Science on p. 733-737

Perspectives on electrostatics and conformational motions in enzyme catalysis

Philip Hanoian, C. Tony Liu, Sharon Hammes-Schiffer, Stephen Benkovic, 2015, Accounts of Chemical Research on p. 482-489

Ring structure and aromatic substituent effects on the p K <sub>a</sub> of the benzoxaborole pharmacophore

John W. Tomsho, Arnab Pal, Dennis G. Hall, Stephen J. Benkovic, 2012, ACS Medicinal Chemistry Letters on p. 48-52

Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction

Vanja Stojković, Laura L. Perissinotti, Daniel Willmer, Stephen J. Benkovic, Amnon Kohen, 2012, Journal of the American Chemical Society on p. 1738-1745

The unique chemistry of benzoxaboroles

C. Tony Liu, John W. Tomsho, Stephen J. Benkovic, 2014, Bioorganic and Medicinal Chemistry on p. 4462-4473

Substrate-driven chemotactic assembly in an enzyme cascade

Xi Zhao, Henri Palacci, Vinita Yadav, Michelle M. Spiering, Michael K. Gilson, Peter J. Butler, Henry Hess, Stephen J. Benkovic, Ayusman Sen, 2018, Nature Chemistry on p. 311-317

Tunable, pulsatile chemical gradient generation via acoustically driven oscillating bubbles

Daniel Ahmed, Chung Yu Chan, Sz Chin Steven Lin, Hari S. Muddana, Nitesh Nama, Stephen J. Benkovic, Tony Jun Huang, 2013, Lab on a Chip - Miniaturisation for Chemistry and Biology on p. 328-331

DNA polymerase as a molecular motor and pump

Samudra Sengupta, Michelle M. Spiering, Krishna K. Dey, Wentao Duan, Debabrata Patra, Peter J. Butler, R. Dean Astumian, Stephen J. Benkovic, Ayusman Sen, 2014, ACS Nano on p. 2410-2418