Stephen Benkovic

Evan Pugh University Professor and Eberly Chair in Chemistry

Stephen Benkovic

Huck Affiliations

Links

Publication Tags

Enzymes Dna Proteins Proliferating Cell Nuclear Antigen Single Stranded Dna Tetrahydrofolate Dehydrogenase Purine Catalysis Isotopes Hydrides Replication Protein A Haemophilus Influenzae Type B Polysaccharide Vaccine Diphtheria Mitochondria Temperature Kinetics Boronic Acids Okazaki Fragments Cracks Holoenzymes Biosynthetic Pathways Recycling Substrates Clamping Devices Escherichia Coli Microtubules

Most Recent Papers

Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria

Chung Yu Chan, Anthony M. Pedley, Doory Kim, Chenglong Xia, Xiaowei Zhuang, Stephen Benkovic, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 13009-13014

Role of HSP90 in the Regulation of de Novo Purine Biosynthesis

Anthony M. Pedley, Georgios I. Karras, Xin Zhang, Susan Lindquist, Stephen Benkovic, 2018, Biochemistry on p. 3217-3221

Substrate-driven chemotactic assembly in an enzyme cascade

Xi Zhao, Henri Palacci, Vinita Yadav, Michelle Marie Spiering, Michael K. Gilson, Peter J. Butler, Henry Hess, Stephen Benkovic, Ayusman Sen, 2018, Nature Chemistry on p. 311-317

Expression of the purine biosynthetic enzyme phosphoribosyl formylglycinamidine synthase in neurons

Colleen Mangold, Pamela Yao, Mei Du, Willard Freeman, Stephen Benkovic, Moriah Szpara, 2018, Journal of Neurochemistry on p. 723--735

Understanding DNA replication by the bacteriophage T4 replisome

Stephen Benkovic, Michelle Spiering, 2017, Journal of Biological Chemistry on p. 18434-18442

Monitoring the Retention of Human Proliferating Cell Nuclear Antigen at Primer/Template Junctions by Proteins That Bind Single-Stranded DNA

Mark Hedglin, Mahesh Aitha, Stephen J. Benkovic, 2017, Biochemistry on p. 3415-3421

RNA primer-primase complexes serve as the signal for polymerase recycling and Okazaki fragment initiation in T4 phage DNA replication

Michelle Marie Spiering, Philip Hanoian, Swathi Gannavaram, Stephen Benkovic, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. 5635-5640

Replication Protein A Prohibits Diffusion of the PCNA Sliding Clamp along Single-Stranded DNA

Mark Hedglin, Stephen J. Benkovic, 2017, Biochemistry on p. 1824-1835

Characterization of human translesion DNA synthesis across a UV-induced DNA lesion

Mark Hedglin, Binod Pandey, Stephen J. Benkovic, 2016, eLife

Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis

Mark Hedglin, Binod Pandey, Stephen J. Benkovic, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. E1777-E1786

Most-Cited Papers

On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves

Xiaoyun Ding, Sz Chin Steven Lin, Brian Kiraly, Hongjun Yue, Sixing Li, I. Kao Chiang, Jinjie Shi, Stephen J. Benkovic, Tony Jun Huang, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. 11105-11109

A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis

Gira Bhabha, Jeeyeon Lee, Damian C. Ekiert, Jongsik Gam, Ian A. Wilson, H. Jane Dyson, Stephen J. Benkovic, Peter E. Wright, 2011, Science on p. 234-238

Controlling cell-cell interactions using surface acoustic waves

Feng Guo, Peng Li, Jarrod B. French, Zhangming Mao, Hong Zhao, Sixing Li, Nitesh Nama, James R. Fick, Stephen J. Benkovic, Tony Jun Huang, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. 43-48

Boron-containing inhibitors of synthetases

Stephen J. Baker, John W. Tomsho, Stephen J. Benkovic, 2011, Chemical Society Reviews on p. 4279-4285

Flexibility, diversity, and cooperativity

Gordon G. Hammes, Stephen J. Benkovic, Sharon Hammes-Schiffer, 2011, Biochemistry on p. 10422-10430

Evolution of cyclic peptide protease inhibitors

Travis S. Young, Douglas D. Young, Insha Ahmad, John M. Louis, Stephen J. Benkovic, Peter G. Schultz, 2011, Proceedings of the National Academy of Sciences of the United States of America on p. 11052-11056

Spatial colocalization and functional link of purinosomes with mitochondria

Jarrod B. French, Sara A. Jones, Huayun Deng, Anthony M. Pedley, Doory Kim, Chung Yu Chan, Haibei Hu, Raymond J. Pugh, Hong Zhao, Youxin Zhang, Tony Jun Huang, Ye Fang, Xiaowei Zhuang, Stephen J. Benkovic, 2016, Science on p. 733-737

Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction

Vanja Stojković, Laura L. Perissinotti, Daniel Willmer, Stephen J. Benkovic, Amnon Kohen, 2012, Journal of the American Chemical Society on p. 1738-1745

Ring structure and aromatic substituent effects on the p K <sub>a</sub> of the benzoxaborole pharmacophore

John W. Tomsho, Arnab Pal, Dennis G. Hall, Stephen J. Benkovic, 2012, ACS Medicinal Chemistry Letters on p. 48-52

GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis

Florence Verrier, Songon An, Ann M. Ferrie, Haiyan Sun, Minjoung Kyoung, Huayun Deng, Ye Fang, Stephen J. Benkovic, 2011, Nature Chemical Biology on p. 909-915