Stephen Benkovic
Evan Pugh University Professor and Eberly Chair in Chemistry

-
414 Wartik
University Park, PA - sjb1@psu.edu
- 814-865-2882
Publication Tags
Enzymes Dna Proteins Proliferating Cell Nuclear Antigen Single Stranded Dna Tetrahydrofolate Dehydrogenase Purine Catalysis Isotopes Hydrides Replication Protein A Haemophilus Influenzae Type B Polysaccharide Vaccine Diphtheria Mitochondria Temperature Kinetics Boronic Acids Okazaki Fragments Cracks Holoenzymes Biosynthetic Pathways Recycling Substrates Clamping Devices Escherichia Coli MicrotubulesMost Recent Papers
Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria
Chung Yu Chan, Anthony M. Pedley, Doory Kim, Chenglong Xia, Xiaowei Zhuang, Stephen Benkovic, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 13009-13014
Role of HSP90 in the Regulation of de Novo Purine Biosynthesis
Anthony M. Pedley, Georgios I. Karras, Xin Zhang, Susan Lindquist, Stephen Benkovic, 2018, Biochemistry on p. 3217-3221
Substrate-driven chemotactic assembly in an enzyme cascade
Xi Zhao, Henri Palacci, Vinita Yadav, Michelle Marie Spiering, Michael K. Gilson, Peter J. Butler, Henry Hess, Stephen Benkovic, Ayusman Sen, 2018, Nature Chemistry on p. 311-317
Expression of the purine biosynthetic enzyme phosphoribosyl formylglycinamidine synthase in neurons
Colleen Mangold, Pamela Yao, Mei Du, Willard Freeman, Stephen Benkovic, Moriah Szpara, 2018, Journal of Neurochemistry on p. 723--735
Understanding DNA replication by the bacteriophage T4 replisome
Stephen Benkovic, Michelle Spiering, 2017, Journal of Biological Chemistry on p. 18434-18442
Monitoring the Retention of Human Proliferating Cell Nuclear Antigen at Primer/Template Junctions by Proteins That Bind Single-Stranded DNA
Mark Hedglin, Mahesh Aitha, Stephen J. Benkovic, 2017, Biochemistry on p. 3415-3421
RNA primer-primase complexes serve as the signal for polymerase recycling and Okazaki fragment initiation in T4 phage DNA replication
Michelle Marie Spiering, Philip Hanoian, Swathi Gannavaram, Stephen Benkovic, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. 5635-5640
Replication Protein A Prohibits Diffusion of the PCNA Sliding Clamp along Single-Stranded DNA
Mark Hedglin, Stephen J. Benkovic, 2017, Biochemistry on p. 1824-1835
Characterization of human translesion DNA synthesis across a UV-induced DNA lesion
Mark Hedglin, Binod Pandey, Stephen J. Benkovic, 2016, eLife
Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis
Mark Hedglin, Binod Pandey, Stephen J. Benkovic, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. E1777-E1786
Most-Cited Papers
On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves
Xiaoyun Ding, Sz Chin Steven Lin, Brian Kiraly, Hongjun Yue, Sixing Li, I. Kao Chiang, Jinjie Shi, Stephen J. Benkovic, Tony Jun Huang, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. 11105-11109
A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis
Gira Bhabha, Jeeyeon Lee, Damian C. Ekiert, Jongsik Gam, Ian A. Wilson, H. Jane Dyson, Stephen J. Benkovic, Peter E. Wright, 2011, Science on p. 234-238
Controlling cell-cell interactions using surface acoustic waves
Feng Guo, Peng Li, Jarrod B. French, Zhangming Mao, Hong Zhao, Sixing Li, Nitesh Nama, James R. Fick, Stephen J. Benkovic, Tony Jun Huang, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. 43-48
Boron-containing inhibitors of synthetases
Stephen J. Baker, John W. Tomsho, Stephen J. Benkovic, 2011, Chemical Society Reviews on p. 4279-4285
Flexibility, diversity, and cooperativity
Gordon G. Hammes, Stephen J. Benkovic, Sharon Hammes-Schiffer, 2011, Biochemistry on p. 10422-10430
Evolution of cyclic peptide protease inhibitors
Travis S. Young, Douglas D. Young, Insha Ahmad, John M. Louis, Stephen J. Benkovic, Peter G. Schultz, 2011, Proceedings of the National Academy of Sciences of the United States of America on p. 11052-11056
Spatial colocalization and functional link of purinosomes with mitochondria
Jarrod B. French, Sara A. Jones, Huayun Deng, Anthony M. Pedley, Doory Kim, Chung Yu Chan, Haibei Hu, Raymond J. Pugh, Hong Zhao, Youxin Zhang, Tony Jun Huang, Ye Fang, Xiaowei Zhuang, Stephen J. Benkovic, 2016, Science on p. 733-737
Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction
Vanja Stojković, Laura L. Perissinotti, Daniel Willmer, Stephen J. Benkovic, Amnon Kohen, 2012, Journal of the American Chemical Society on p. 1738-1745
Ring structure and aromatic substituent effects on the p K <sub>a</sub> of the benzoxaborole pharmacophore
John W. Tomsho, Arnab Pal, Dennis G. Hall, Stephen J. Benkovic, 2012, ACS Medicinal Chemistry Letters on p. 48-52
GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis
Florence Verrier, Songon An, Ann M. Ferrie, Haiyan Sun, Minjoung Kyoung, Huayun Deng, Ye Fang, Stephen J. Benkovic, 2011, Nature Chemical Biology on p. 909-915