Stephen Benkovic

Evan Pugh University Professor and Eberly Chair in Chemistry

Stephen Benkovic

Huck Affiliations


Publication Tags

Enzymes Proteins Dna Purine Catalysis Proliferating Cell Nuclear Antigen Tetrahydrofolate Dehydrogenase Hydrides Isotopes Boronic Acids Mitochondria Replication Protein A Neurons Single Stranded Dna Kinetics Temperature Escherichia Coli Biosynthetic Pathways Substrates Purines Cracks Computer Simulation Biosynthesis Nucleotides Microtubules

Most Recent Papers

Rapid generation of incremental truncation libraries for protein engineering using α-phosphothioate nucleotides

Stefan Lutz, Marc Ostermeier, Stephen J. Benkovic, 2021, Nucleic Acids Research

PCNA Monoubiquitination Is Regulated by Diffusion of Rad6/Rad18 Complexes along RPA Filaments

Mingjie Li, Bhaswati Sengupta, Stephen J. Benkovic, Tae Hee Lee, Mark Hedglin, 2020, Biochemistry on p. 4694-4702

Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria

Chung Yu Chan, Anthony M. Pedley, Doory Kim, Chenglong Xia, Xiaowei Zhuang, Stephen Benkovic, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 13009-13014

Role of HSP90 in the Regulation of de Novo Purine Biosynthesis

Anthony M. Pedley, Georgios I. Karras, Xin Zhang, Susan Lindquist, Stephen Benkovic, 2018, Biochemistry on p. 3217-3221

Expression of the purine biosynthetic enzyme phosphoribosyl formylglycinamidine synthase in neurons

Colleen Mangold, Pamela Yao, Mei Du, Willard Freeman, Stephen Benkovic, Moriah Szpara, 2018, Journal of Neurochemistry on p. 723--735

Substrate-driven chemotactic assembly in an enzyme cascade

Xi Zhao, Henri Palacci, Vinita Yadav, Michelle Marie Spiering, Michael K. Gilson, Peter J. Butler, Henry Hess, Stephen Benkovic, Ayusman Sen, 2018, Nature Chemistry on p. 311-317

Detecting purinosome metabolon formation with fluorescence microscopy

Anthony M. Pedley, Stephen J. Benkovic, 2018, on p. 279-289

Understanding DNA replication by the bacteriophage T4 replisome

Stephen J. Benkovic, Michelle M. Spiering, 2017, Journal of Biological Chemistry on p. 18434-18442

Monitoring the Retention of Human Proliferating Cell Nuclear Antigen at Primer/Template Junctions by Proteins That Bind Single-Stranded DNA

Mark Hedglin, Mahesh Aitha, Stephen J. Benkovic, 2017, Biochemistry on p. 3415-3421

Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands

Mark Hedglin, Stephen J. Benkovic, 2017, Chemical Reviews on p. 7857-7877

Most-Cited Papers

A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis

Gira Bhabha, Jeeyeon Lee, Damian C. Ekiert, Jongsik Gam, Ian A. Wilson, H. Jane Dyson, Stephen J. Benkovic, Peter E. Wright, 2011, Science on p. 234-238

Controlling cell-cell interactions using surface acoustic waves

Feng Guo, Peng Li, Jarrod B. French, Zhangming Mao, Hong Zhao, Sixing Li, Nitesh Nama, James R. Fick, Stephen J. Benkovic, Tony Jun Huang, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. 43-48

Boron-containing inhibitors of synthetases

Stephen J. Baker, John W. Tomsho, Stephen J. Benkovic, 2011, Chemical Society Reviews on p. 4279-4285

Flexibility, diversity, and cooperativity

Gordon G. Hammes, Stephen J. Benkovic, Sharon Hammes-Schiffer, 2011, Biochemistry on p. 10422-10430

A New View into the Regulation of Purine Metabolism

Anthony M. Pedley, Stephen J. Benkovic, 2017, Trends in Biochemical Sciences on p. 141-154

Evolution of cyclic peptide protease inhibitors

Travis S. Young, Douglas D. Young, Insha Ahmad, John M. Louis, Stephen J. Benkovic, Peter G. Schultz, 2011, Proceedings of the National Academy of Sciences of the United States of America on p. 11052-11056

Spatial colocalization and functional link of purinosomes with mitochondria

Jarrod B. French, Sara A. Jones, Huayun Deng, Anthony M. Pedley, Doory Kim, Chung Yu Chan, Haibei Hu, Raymond J. Pugh, Hong Zhao, Youxin Zhang, Tony Jun Huang, Ye Fang, Xiaowei Zhuang, Stephen J. Benkovic, 2016, Science on p. 733-737

Perspectives on electrostatics and conformational motions in enzyme catalysis

Philip Hanoian, C. Tony Liu, Sharon Hammes-Schiffer, Stephen Benkovic, 2015, Accounts of Chemical Research on p. 482-489

Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction

Vanja Stojković, Laura L. Perissinotti, Daniel Willmer, Stephen J. Benkovic, Amnon Kohen, 2012, Journal of the American Chemical Society on p. 1738-1745

Ring structure and aromatic substituent effects on the p K <sub>a</sub> of the benzoxaborole pharmacophore

John W. Tomsho, Arnab Pal, Dennis G. Hall, Stephen J. Benkovic, 2012, ACS Medicinal Chemistry Letters on p. 48-52