Stephen Benkovic

Evan Pugh University Professor and Eberly Chair in Chemistry

Stephen Benkovic

Huck Affiliations

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Publication Tags

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Purine Enzymes Biosynthesis Escherichia Coli Catalysis Protein Pumps Electrostatics Proteins Metabolic Nucleotides Tetrahydrofolate Dehydrogenase Dna Purine Nucleotides Static Electricity Inosine Monophosphate Adenosine Monophosphate Biotechnology Dihydrofolates Mitochondria Hydrides Substrates Probe Hydride Cofactor

Most Recent Publications

Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models

Qian Ma, Qiuhua Yang, Jiean Xu, Hunter G. Sellers, Zach L. Brown, Zhiping Liu, Zsuzsanna Bordan, Xiaofan Shi, Dingwei Zhao, Yongfeng Cai, Vidhi Pareek, Chunxiang Zhang, Guangyu Wu, Zheng Dong, Alexander D. Verin, Lin Gan, Quansheng Du, Stephen J. Benkovic, Suowen Xu, John M. Asara, Issam Ben-Sahra, Scott Barman, Yunchao Su, David J.R. Fulton, Yuqing Huo, 2023, European Heart Journal on p. 1265-1279

ATIC-Associated De Novo Purine Synthesis Is Critically Involved in Proliferative Arterial Disease

Qian Ma, Qiuhua Yang, Jiean Xu, Xiaoyu Zhang, David Kim, Zhiping Liu, Qingen Da, Xiaoxiao Mao, Yaqi Zhou, Yongfeng Cai, Vidhi Pareek, Ha Won Kim, Guangyu Wu, Zheng Dong, Wen Liang Song, Lin Gan, Chunxiang Zhang, Mei Hong, Stephen J. Benkovic, Neal L. Weintraub, David Fulton, John M. Asara, Issam Ben-Sahra, Yuqing Huo, 2022, Circulation on p. 1444-1460

Purine biosynthetic enzymes assemble into liquid-like condensates dependent on the activity of chaperone protein HSP90

Anthony M. Pedley, Jack P. Boylan, Chung Yu Chan, Erin L. Kennedy, Minjoung Kyoung, Stephen J. Benkovic, 2022, Journal of Biological Chemistry

Multienzyme interactions of the de novo purine biosynthetic protein PAICS facilitate purinosome formation and metabolic channeling

Jingxuan He, Ling Nan Zou, Vidhi Pareek, Stephen J. Benkovic, 2022, Journal of Biological Chemistry

The Purinosome: A Case Study for a Mammalian Metabolon

Anthony M. Pedley, Vidhi Pareek, Stephen J. Benkovic, 2022, Annual Review of Biochemistry on p. 89-106

Metabolic channeling: predictions, deductions, and evidence

Vidhi Pareek, Zhou Sha, Jingxuan He, S Benkovic, 2021, Molecular Cell on p. 3775-3785

Replication: DNA replication fork, bacterial

M. M. Spiering, S. J. Benkovic, 2021, on p. 49-53

From Bioorganic Models to Cells

Stephen J. Benkovic, 2021, Annual Review of Biochemistry on p. 57-76

Rapid generation of incremental truncation libraries for protein engineering using α-phosphothioate nucleotides

Stefan Lutz, Marc Ostermeier, Stephen J. Benkovic, 2021, Nucleic Acids Research

Human de novo purine biosynthesis

Vidhi Pareek, Anthony M. Pedley, Stephen J. Benkovic, 2021, Critical Reviews in Biochemistry and Molecular Biology on p. 1-16

Most-Cited Papers

A New View into the Regulation of Purine Metabolism: The Purinosome

Anthony M. Pedley, Stephen J. Benkovic, 2017, Trends in Biochemical Sciences on p. 141-154

Controlling cell-cell interactions using surface acoustic waves

Feng Guo, Peng Li, Jarrod B. French, Zhangming Mao, Hong Zhao, Sixing Li, Nitesh Nama, James R. Fick, Stephen J. Benkovic, Tony Jun Huang, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. 43-48

Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells

Vidhi Pareek, Hua Tian, Nicholas Winograd, Stephen J. Benkovic, 2020, Science on p. 283-290

Spatial colocalization and functional link of purinosomes with mitochondria

Jarrod B. French, Sara A. Jones, Huayun Deng, Anthony M. Pedley, Doory Kim, Chung Yu Chan, Haibei Hu, Raymond J. Pugh, Hong Zhao, Youxin Zhang, Tony Jun Huang, Ye Fang, Xiaowei Zhuang, Stephen J. Benkovic, 2016, Science on p. 733-737

Perspectives on electrostatics and conformational motions in enzyme catalysis

Philip Hanoian, C. Tony Liu, Sharon Hammes-Schiffer, Stephen Benkovic, 2015, Accounts of Chemical Research on p. 482-489

Substrate-driven chemotactic assembly in an enzyme cascade

Xi Zhao, Henri Palacci, Vinita Yadav, Michelle M. Spiering, Michael Gilson, Peter Butler, Henry Hess, Stephen J. Benkovic, Ayusman Sen, 2018, Nature Chemistry on p. 311--317

The unique chemistry of benzoxaboroles: Current and emerging applications in biotechnology and therapeutic treatments

C. Tony Liu, John W. Tomsho, Stephen J. Benkovic, 2014, Bioorganic and Medicinal Chemistry on p. 4462-4473

DNA polymerase as a molecular motor and pump

Samudra Sengupta, Michelle M. Spiering, Krishna K. Dey, Wentao Duan, Debabrata Patra, Peter J. Butler, R. Dean Astumian, Stephen J. Benkovic, Ayusman Sen, 2014, ACS Nano on p. 2410-2418

Quantitative analysis of purine nucleotides indicates that purinosomes increase de Novo purine biosynthesis

Hong Zhao, Christopher R. Chiaro, Limin Zhang, Philip B. Smith, Chung Yu Chan, Anthony M. Pedley, Raymond J. Pugh, Jarrod B. French, Andrew D. Patterson, Stephen J. Benkovic, 2015, Journal of Biological Chemistry on p. 6705-6713

Probing the electrostatics of active site microenvironments along the catalytic cycle for escherichia coli dihydrofolate reductase

C. Tony Liu, Joshua P. Layfield, Robert J. Stewart, Jarrod B. French, Philip Hanoian, John B. Asbury, Sharon Hammes-Schiffer, Stephen J. Benkovic, 2014, Journal of the American Chemical Society on p. 10349-10360

News Articles Featuring Stephen Benkovic

Feb 15, 2024

Committee advances plan to rename Chemistry Building as 'Benkovic Building'

The Chemistry Building at the University Park campus will be renamed in honor of the careerlong scholarly impact of Stephen Benkovic, Atherton Professor of Chemistry

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Jan 22, 2024

Engineering professor named National Academy of Inventors fellow

The National Academy of Inventors (NAI) named Qiming Zhang, distinguished professor of electrical engineering in the College of Engineering, a fellow

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Jul 06, 2023

Penn State chemist Stephen Benkovic named Atherton Professor

Stephen Benkovic, Evan Pugh Professor and Holder of the Eberly Family Chair in Chemistry at Penn State, has been honored by Penn State with the title of Atherton Professor.

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Feb 23, 2023

Nobel Prize-winning Penn State alumnus Paul Berg dies

Penn State alumnus Paul Berg, who received the 1980 Nobel Prize in chemistry, died Feb. 15 at his home in Stanford, California, surrounded by loved ones. He was 96.

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Dec 08, 2022

National Academy of Inventors names three Penn Staters as 2022 fellows

The National Academy of Inventors (NAI) named three Penn State College of Engineering faculty members as fellows, the highest professional distinction awarded to academic inventors.

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Sep 02, 2022

Metabolomics Core Facility continues to expand while pushing scientific bounds

Established nearly a decade ago, Penn State’s Metabolomics Core Facility is housed in the Huck Institutes of the Life Sciences on the University Park campus.

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Feb 07, 2022

Benkovics support pioneering research in chemistry and the life sciences

You might think of Patricia and Stephen Benkovic as Penn State’s “first couple of chemistry,” considering all the pioneering contributions they’ve made at the University in their shared discipline over a span of more than five decades. Now the pair are giving back to their research community in an exciting new way, hoping to inspire the next generation of scientists to carry the torch of innovation and discovery to even greater heights.

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May 07, 2021

Pioneering chemist Stephen Benkovic elected Foreign Member of Royal Society 6

Stephen Benkovic, Evan Pugh Professor and Holder of the Eberly Family Chair in Chemistry at Penn State, has been elected a Foreign Member of the Royal Society, the national academy of science in the United Kingdom. The society, founded in 1660, aims to recognize, promote and support excellence in science and to encourage the development and use of science for the benefit of humanity.

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