Stephen Benkovic

Evan Pugh University Professor and Eberly Chair in Chemistry

Stephen Benkovic

Huck Affiliations


Publication Tags

Purine Enzymes Dna Biosynthesis Pumps Isotopes Nucleotides Boronic Acids Tetrahydrofolate Dehydrogenase Hydrides Cells Protein Catalysis Proteins Biotechnology Replication Protein A Hydride Metabolomics Purines Benzoxaborole Mass Spectrometry Proliferating Cell Nuclear Antigen Mass Spectroscopy Synthesis Dihydrofolates

Most Recent Papers

Purine biosynthetic enzymes assemble into liquid-like condensates dependent on the activity of chaperone protein HSP90

Anthony M. Pedley, Jack P. Boylan, Chung Yu Chan, Erin L. Kennedy, Minjoung Kyoung, Stephen J. Benkovic, 2022, Journal of Biological Chemistry

Multienzyme interactions of the de novo purine biosynthetic protein PAICS facilitate purinosome formation and metabolic channeling

Jingxuan He, Ling Nan Zou, Vidhi Pareek, Stephen J. Benkovic, 2022, Journal of Biological Chemistry

Metabolic channeling: predictions, deductions, and evidence

Vidhi Pareek, Zhou Sha, Jingxuan He, S Benkovic, 2021, Molecular Cell on p. 3775-3785


M. M. Spiering, S. J. Benkovic, 2021, on p. 49-53

From Bioorganic Models to Cells

Stephen J. Benkovic, 2021, Annual Review of Biochemistry on p. 57-76

Rapid generation of incremental truncation libraries for protein engineering using α-phosphothioate nucleotides

Stefan Lutz, Marc Ostermeier, Stephen J. Benkovic, 2021, Nucleic Acids Research

Human de novo purine biosynthesis

Vidhi Pareek, Anthony M. Pedley, Stephen J. Benkovic, 2021, Critical Reviews in Biochemistry and Molecular Biology on p. 1-16

PCNA Monoubiquitination Is Regulated by Diffusion of Rad6/Rad18 Complexes along RPA Filaments

Mingjie Li, Bhaswati Sengupta, Stephen J. Benkovic, Tae Hee Lee, Mark Hedglin, 2020, Biochemistry on p. 4694-4702

Hypoxia drives the assembly of the multienzyme purinosome complex

Cyrielle Doigneaux, Anthony M. Pedley, Ishna N. Mistry, Monika Papayova, Stephen J. Benkovic, Ali Tavassoli, 2020, Journal of Biological Chemistry on p. 9551-9566

Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells

Vidhi Pareek, Hua Tian, Nicholas Winograd, Stephen J. Benkovic, 2020, Science on p. 283-290

Most-Cited Papers

Controlling cell-cell interactions using surface acoustic waves

Feng Guo, Peng Li, Jarrod B. French, Zhangming Mao, Hong Zhao, Sixing Li, Nitesh Nama, James R. Fick, Stephen J. Benkovic, Tony Jun Huang, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. 43-48

A New View into the Regulation of Purine Metabolism

Anthony M. Pedley, Stephen J. Benkovic, 2017, Trends in Biochemical Sciences on p. 141-154

Spatial colocalization and functional link of purinosomes with mitochondria

Jarrod B. French, Sara A. Jones, Huayun Deng, Anthony M. Pedley, Doory Kim, Chung Yu Chan, Haibei Hu, Raymond J. Pugh, Hong Zhao, Youxin Zhang, Tony Jun Huang, Ye Fang, Xiaowei Zhuang, Stephen J. Benkovic, 2016, Science on p. 733-737

Perspectives on electrostatics and conformational motions in enzyme catalysis

Philip Hanoian, C. Tony Liu, Sharon Hammes-Schiffer, Stephen Benkovic, 2015, Accounts of Chemical Research on p. 482-489

Ring structure and aromatic substituent effects on the p K <sub>a</sub> of the benzoxaborole pharmacophore

John W. Tomsho, Arnab Pal, Dennis G. Hall, Stephen J. Benkovic, 2012, ACS Medicinal Chemistry Letters on p. 48-52

Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction

Vanja Stojković, Laura L. Perissinotti, Daniel Willmer, Stephen J. Benkovic, Amnon Kohen, 2012, Journal of the American Chemical Society on p. 1738-1745

The unique chemistry of benzoxaboroles

C. Tony Liu, John W. Tomsho, Stephen J. Benkovic, 2014, Bioorganic and Medicinal Chemistry on p. 4462-4473

Substrate-driven chemotactic assembly in an enzyme cascade

Xi Zhao, Henri Palacci, Vinita Yadav, Michelle M. Spiering, Michael K. Gilson, Peter J. Butler, Henry Hess, Stephen J. Benkovic, Ayusman Sen, 2018, Nature Chemistry on p. 311-317

Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells

Vidhi Pareek, Hua Tian, Nicholas Winograd, Stephen J. Benkovic, 2020, Science on p. 283-290

DNA polymerase as a molecular motor and pump

Samudra Sengupta, Michelle M. Spiering, Krishna K. Dey, Wentao Duan, Debabrata Patra, Peter J. Butler, R. Dean Astumian, Stephen J. Benkovic, Ayusman Sen, 2014, ACS Nano on p. 2410-2418