Scott Lindner

Co-Director, Center for Malaria Research; Associate Professor of Biochemistry & Molecular Biology

Scott Lindner

Research Summary

RNA/protein complexes, translational control, and the specialized ribosomes of malaria parasites using sequencing, proteomics, and genetic approaches with a focus on the transmission stages of Plasmodium parasites between mammals and mosquitoes

Huck Affiliations

Links

Most Recent Publications

Microbiome-mediated modulation of immune memory to P. yoelii affects the resistance to secondary cerebral malaria challenge

Elizabeth M. Fusco, Layne Bower, Rafael Polidoro, Allen M. Minns, Scott E. Lindner, Nathan W. Schmidt, 2025, ImmunoHorizons

Secondary Germinal Center Response to Plasmodium Reinfection is Affected by the Composition of the Gut Microbiome

Scott Lindner, 2025, ImmunoHorizons

Widespread release of translational repression across Plasmodium’s host-to-vector transmission event

Kelly T. Rios, James P. McGee, Aswathy Sebastian, Sanjaya Aththawala Gedara, Robert L. Moritz, Marina Feric, Sabrina Absalon, Kristian E. Swearingen, Scott E. Lindner, 2025, PLoS Pathogens

Systemic 4-1BB stimulation augments extrafollicular memory B cell formation and recall responses during Plasmodium infection

Scott Lindner, 2025, Cell Reports

The DEAD-box RNA helicase PfDOZI imposes opposing actions on RNA metabolism in Plasmodium falciparum

Hui Min, Xiaoying Liang, Chengqi Wang, Junling Qin, Rachasak Boonhok, Azhar Muneer, Awtum M. Brashear, Xiaolian Li, Allen M. Minns, Swamy Rakesh Adapa, Rays H.Y. Jiang, Gang Ning, Yaming Cao, Scott E. Lindner, Jun Miao, Liwang Cui, 2024, Nature Communications

CD4 T Cell–Derived IL-21 Is Critical for Sustaining Plasmodium Infection–Induced Germinal Center Responses and Promoting the Selection of Memory B Cells with Recall Potential

Jordan T. Johnson, Fionna A. Surette, Graham R. Ausdal, Manan Shah, Allen M. Minns, Scott E. Lindner, Ryan A. Zander, Noah S. Butler, 2024, Journal of Immunology on p. 1467-1478

Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model

Devanshi R. Patel, Allen M. Minns, Derek G. Sim, Cassandra J. Field, Abigail E. Kerr, Talia A. Heinly, Erin H. Luley, Randall M. Rossi, Carol M. Bator, Ibrahim M. Moustafa, Elizabeth B. Norton, Susan L. Hafenstein, Scott E. Lindner, Troy C. Sutton, 2024, Microbiology spectrum

Long-read genome assembly and gene model annotations for the rodent malaria parasite Plasmodium yoelii 17XNL

Mitchell J. Godin, Aswathy Sebastian, Istvan Albert, Scott E. Lindner, 2023, Journal of Biological Chemistry

Ribosome heterogeneity and specialization of Plasmodium parasites

James P. McGee, Jean Paul Armache, Scott E. Lindner, 2023, PLoS Pathogens

Comparative proteomics of vesicles essential for the egress of Plasmodium falciparum gametocytes from red blood cells

Juliane Sassmannshausen, Sandra Bennink, Ute Distler, Juliane Küchenhoff, Allen M. Minns, Scott E. Lindner, Paul Christian Burda, Stefan Tenzer, Tim W. Gilberger, Gabriele Pradel, 2023, Molecular Microbiology

Most-Cited Papers

Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice

Sebastian A. Mikolajczak, Ashley M. Vaughan, Niwat Kangwanrangsan, Wanlapa Roobsoong, Matthew Fishbaugher, Narathatai Yimamnuaychok, Nastaran Rezakhani, Viswanathan Lakshmanan, Naresh Singh, Alexis Kaushansky, Nelly Camargo, Michael Baldwin, Scott E. Lindner, John H. Adams, Jetsumon Sattabongkot, Stefan H.I. Kappe, 2015, Cell Host and Microbe on p. 526-535

Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics

Kristian E. Swearingen, Scott E. Lindner, Lirong Shi, Melanie J. Shears, Anke Harupa, Christine S. Hopp, Ashley M. Vaughan, Timothy A. Springer, Robert L. Moritz, Stefan H.I. Kappe, Photini Sinnis, 2016, PLoS Pathogens

Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

Scott E. Lindner, Kristian E. Swearingen, Melanie J. Shears, Michael P. Walker, Erin N. Vrana, Kevin J. Hart, Allen M. Minns, Photini Sinnis, Robert L. Moritz, Stefan H.I. Kappe, 2019, Nature Communications

Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodium vivax salivary gland sporozoites

Kristian E. Swearingen, Scott E. Lindner, Erika L. Flannery, Ashley M. Vaughan, Robert D. Morrison, Rapatbhorn Patrapuvich, Cristian Koepfli, Ivo Muller, Aaron Jex, Robert L. Moritz, Stefan H.I. Kappe, Jetsumon Sattabongkot, Sebastian A. Mikolajczak, 2017, PLoS Neglected Tropical Diseases

A bioinformatic survey of RNA-binding proteins in Plasmodium

BP Niranjan Reddy, Sony Shrestha, Kevin J. Hart, Xiaoying Liang, Karen Kemirembe, Liwang Cui, Scott E. Lindner, 2015, BMC Genomics

Translational regulation during stage transitions in malaria parasites

Liwang Cui, Scott Lindner, Jun Miao, 2015, Annals of the New York Academy of Sciences on p. 1-9

Th1-like Plasmodium-Specific Memory CD4<sup>+</sup> T Cells Support Humoral Immunity

Ryan A. Zander, Rahul Vijay, Angela D. Pack, Jenna J. Guthmiller, Amy C. Graham, Scott E. Lindner, Ashley M. Vaughan, Stefan H.I. Kappe, Noah S. Butler, 2017, Cell Reports on p. 1839-1852

Cutting back malaria: CRISPR/Cas9 genome editing of Plasmodium

Marcus C.S. Lee, Scott E. Lindner, Jose Juan Lopez-Rubio, Manuel Llinás, 2019, Briefings in Functional Genomics and Proteomics on p. 281-289

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malaria

Ivo Muller, Aaron R. Jex, Stefan H.I. Kappe, Sebastian A. Mikolajczak, Jetsumon Sattabongkot, Rapatbhorn Patrapuvich, Scott Lindner, Erika L. Flannery, Cristian Koepfli, Brendan Ansell, Anita Lerch, Samantha J. Emery-Corbin, Sarah Charnaud, Jeffrey Smith, Nicolas Merrienne, Kristian E. Swearingen, Robert L. Moritz, Michaela Petter, Michael F. Duffy, Vorada Chuenchob, 2019, International Journal for Parasitology on p. 501-513

ALBA4 modulates its stage-specific interactions and specific mRNA fates during Plasmodium yoelii growth and transmission

Elyse E. Muñoz, Kevin J. Hart, Michael P. Walker, Mark F. Kennedy, Mackenzie M. Shipley, Scott E. Lindner, 2017, Molecular Microbiology on p. 266-284

News Articles Featuring Scott Lindner

Jul 23, 2025

Seasonal flu immunity protects against severe illness from bird flu in ferrets

A study in ferrets — which have remarkably similar respiratory systems to humans — suggests that widespread immunity to H1N1 seasonal influenza virus may explain why exposure to H5N1 bird flu causes only mild symptoms in humans.

Full Article

Apr 15, 2024

Huck Leadership Fellows selected for 2024-25

For the 2024-2025 academic year, Huck Institutes of the Life Sciences has appointed Associate Professor of Biomedical Engineering Scott Medina, Professor of Statistics Lingzhou Xue, and Associate Professor of Surgery Dino Ravnic to be Huck Leadership Fellows.

Full Article

Mar 12, 2024

New nasal vaccine platform helps clear COVID-19 infections in an animal model

A newly developed intranasal vaccine candidate helps to clear COVID-19 infections more quickly than controls in pre-clinical testing, according to a recent study.

Full Article

Jun 26, 2023

Neela Yennawar and Scott Lindner selected as 2023 Huck Leadership Fellows

Launched in 2022, the Huck Leadership Fellows Program was developed for faculty members seeking to sharpen their leadership skills with an opportunity for exposure to senior leadership within the interdisciplinary research unit.

Full Article

Feb 25, 2021

Study finds short window for donating convalescent plasma to COVID-19 patients

The optimal timeframe for donating convalescent plasma for use in COVID-19 immunotherapy, which was given emergency-use authorization by the Food and Drug Administration in August 2020, is within 60 days of the onset of symptoms, according to a new Penn State-led study.

Full Article

Feb 25, 2021

Study finds short window for donating convalescent plasma to COVID-19 patients

The optimal timeframe for donating convalescent plasma for use in COVID-19 immunotherapy, which was given emergency use authorization by the Food and Drug Administration in August 2020, is within 60 days of the onset of symptoms, according to a new study. The research also reveals that the ideal convalescent plasma donor is a recovered COVID-19 patient who is older than 30 and whose illness had been severe.

Full Article

Oct 31, 2019

Malaria parasite lives on the edge

The parasite that causes malaria expresses genes that code for the proteins it will need in later life stages, using two separate schemes to prevent these proteins from actually being made until they are needed, according to new research.

Full Article

Jan 31, 2019

Male birth control for the malaria parasite

Full Article