Scott Lindner
Associate Professor of Biochemistry & Molecular Biology, Co-Director, Center for Malaria Research
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W230B Millennium Science Complex
University Park, PA 16802 - He/Him
- sel27@psu.edu
- (814) 867-4062
Research Summary
Our laboratory couples molecular parasitology and structural biology to study the malaria parasite (Plasmodium spp.).
Huck Graduate Students
Huck Affiliations
- Center for Infectious Disease Dynamics
- Molecular, Cellular, and Integrative Biosciences
- Center for RNA Molecular Biology
- Center for Malaria Research
- Center for Structural Biology
Links
Publication Tags
Parasites Proteins Malaria Plasmodium Sporozoites Proteomics Protein Salivary Glands Liver Infections Proteome Machine Learning Plasmodium Yoelii Rna Binding Proteins Plasmodium Falciparum Messenger Rna Sars Virus Infection Wavelength Plasmodium Vivax Thermal Stability Coronavirus Culicidae Antibodies Raman SpectroscopyMost Recent Publications
Understanding the Excitation Wavelength Dependence and Thermal Stability of the SARS-CoV-2 Receptor-Binding Domain Using Surface-Enhanced Raman Scattering and Machine Learning
Kunyan Zhang, Ziyang Wang, He Liu, Néstor Perea-López, Jeewan C. Ranasinghe, George Bepete, Allen M. Minns, Randall M. Rossi, Scott E. Lindner, Sharon X. Huang, Mauricio Terrones, Shengxi Huang, 2022, ACS Photonics
Identification of basal complex protein that is essential for maturation of transmission-stage malaria parasites
Rebecca L. Clements, Alexander A. Morano, Francesca M. Navarro, James P. McGee, Esrah W. Du, Vincent A. Streva, Scott E. Lindner, Jeffrey D. Dvorin, 2022, Proceedings of the National Academy of Sciences of the United States of America
Mitochondrially targeted proximity biotinylation and proteomic analysis in Plasmodium falciparum
Ian M. Lamb, Kelly T. Rios, Anurag Shukla, Avantika I. Ahiya, Joanne Morrisey, Joshua C. Mell, Scott E. Lindner, Michael W. Mather, Akhil B. Vaidya, 2022, PLoS One
Direct type I interferon signaling in hepatocytes controls malaria
Camila Marques-da-Silva, Kristen Peissig, Michael P. Walker, Justine Shiau, Carson Bowers, Dennis E. Kyle, Rahul Vijay, Scott E. Lindner, Samarchith P. Kurup, 2022, Cell Reports
Development and Validation of Indirect Enzyme-Linked Immunosorbent Assays for Detecting Antibodies to SARS-CoV-2 in Cattle, Swine, and Chicken
Abhinay Gontu, Erika A. Marlin, Santhamani Ramasamy, Sabarinath Neerukonda, Gayatri Anil, Jasmine Morgan, Meysoon Quraishi, Chen Chen, Veda Sheersh Boorla, Ruth H. Nissly, Padmaja Jakka, Shubhada K. Chothe, Abirami Ravichandran, Nishitha Kodali, Saranya Amirthalingam, Lindsey Labella, Kathleen Kelly, Pazhanivel Natesan, Allen M. Minns, Randall M. Rossi, Jacob R. Werner, Ernest Hovingh, Scott E. Lindner, Deepanker Tewari, Vivek Kapur, Kurt J. Vandegrift, Costas D. Maranas, Meera Surendran Nair, Suresh V. Kuchipudi, 2022, Viruses
Standard Selection Treatments with Sulfadiazine Limit Plasmodium yoelii Host-to-Vector Transmission
Kelly T. Rios, Taylor M. Dickson, Scott E. Lindner, 2022, mSphere
Addendum: Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites
Scott E. Lindner, Kristian E. Swearingen, Melanie J. Shears, Aswathy Sebastian, Michael P. Walker, Erin N. Vrana, Kevin J. Hart, Allen M. Minns, Istvan Albert, Photini Sinnis, Robert L. Moritz, Stefan H.I. Kappe, 2022, Nature Communications on p. 283
Physical compatibility of Normosol-R with critical care medications used in patients with COVID-19 during simulated Y-site administration
Amanda A. Holyk, Alexandra H. Lindner, Scott E. Lindner, Brian W. Shippert, 2022, Bulletin. American Society of Hospital Pharmacists on p. E27-E33
The Plasmodium NOT1-G paralogue is an essential regulator of sexual stage maturation and parasite transmission
Kevin J. Hart, B. Joanne Power, Kelly T. Rios, Aswathy Sebastian, Scott E. Lindner, 2021, PLoS Biology
Monoclonal antibodies to s and n sars-cov-2 proteins as probes to assess structural and antigenic properties of coronaviruses
R Kumar, Neil D. Christensen, R Kaddis Maldonado, Maria C. Bewley, A Ostman, M Sudol, E Chen, N Buchkovich, A Gontu, Meera Surendran Nair, R Nissly, A Minns, Vivek Kapur, R Rossi, Suresh V. Kuchipudi, Scott E. Lindner, Leslie J. Parent, John M. Flanagan, Nicholas J. Buchkovich, 2021, Viruses
Most-Cited Papers
Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice
Sebastian A. Mikolajczak, Ashley M. Vaughan, Niwat Kangwanrangsan, Wanlapa Roobsoong, Matthew Fishbaugher, Narathatai Yimamnuaychok, Nastaran Rezakhani, Viswanathan Lakshmanan, Naresh Singh, Alexis Kaushansky, Nelly Camargo, Michael Baldwin, Scott E. Lindner, John H. Adams, Jetsumon Sattabongkot, Stefan H.I. Kappe, 2015, Cell Host and Microbe on p. 526-535
Total and putative surface proteomics of malaria parasite salivary gland sporozoites
Scott E. Lindner, Kristian E. Swearingen, Anke Harupa, Ashley M. Vaughan, Photini Sinnis, Robert L. Moritz, Stefan H.I. Kappe, 2013, Molecular and Cellular Proteomics on p. 1127-1143
Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics
Kristian E. Swearingen, Scott E. Lindner, Lirong Shi, Melanie J. Shears, Anke Harupa, Christine S. Hopp, Ashley M. Vaughan, Timothy A. Springer, Robert L. Moritz, Stefan H.I. Kappe, Photini Sinnis, 2016, PLoS Pathogens
Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites
Scott E. Lindner, Kristian E. Swearingen, Melanie J. Shears, Michael P. Walker, Erin N. Vrana, Kevin J. Hart, Allen M. Minns, Photini Sinnis, Robert L. Moritz, Stefan H.I. Kappe, 2019, Nature Communications
Perturbations of PlasmodiumPuf2 expression and RNA-seq of Puf2-deficient sporozoites reveal a critical role in maintaining RNA homeostasis and parasite transmissibility
Scott E. Lindner, Sebastian A. Mikolajczak, Ashley M. Vaughan, Wonjong Moon, Brad R. Joyce, William J. Sullivan, Stefan H.I. Kappe, 2013, Cellular Microbiology on p. 1266-1283
Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodium vivax salivary gland sporozoites
Kristian E. Swearingen, Scott E. Lindner, Erika L. Flannery, Ashley M. Vaughan, Robert D. Morrison, Rapatbhorn Patrapuvich, Cristian Koepfli, Ivo Muller, Aaron Jex, Robert L. Moritz, Stefan H.I. Kappe, Jetsumon Sattabongkot, Sebastian A. Mikolajczak, 2017, PLoS Neglected Tropical Diseases
A bioinformatic survey of RNA-binding proteins in Plasmodium
BP Niranjan Reddy, Sony Shrestha, Kevin J. Hart, Xiaoying Liang, Karen Kemirembe, Liwang Cui, Scott E. Lindner, 2015, BMC Genomics
Translational regulation during stage transitions in malaria parasites
Liwang Cui, Scott Lindner, Jun Miao, 2015, Annals of the New York Academy of Sciences on p. 1-9
Enzymes involved in plastid-targeted phosphatidic acid synthesis are essential for Plasmodium yoelii liver-stage development
Scott E. Lindner, Mark J. Sartain, Kiera Hayes, Anke Harupa, Robert L. Moritz, Stefan H.I. Kappe, Ashley M. Vaughan, 2014, Molecular Microbiology on p. 679-693
Th1-like Plasmodium-Specific Memory CD4<sup>+</sup> T Cells Support Humoral Immunity
Ryan A. Zander, Rahul Vijay, Angela D. Pack, Jenna J. Guthmiller, Amy C. Graham, Scott E. Lindner, Ashley M. Vaughan, Stefan H.I. Kappe, Noah S. Butler, 2017, Cell Reports on p. 1839-1852
News Articles Featuring Scott Lindner
Feb 25, 2021
Study finds short window for donating convalescent plasma to COVID-19 patients
The optimal timeframe for donating convalescent plasma for use in COVID-19 immunotherapy, which was given emergency-use authorization by the Food and Drug Administration in August 2020, is within 60 days of the onset of symptoms, according to a new Penn State-led study.
Full Article
Feb 25, 2021
Study finds short window for donating convalescent plasma to COVID-19 patients
The optimal timeframe for donating convalescent plasma for use in COVID-19 immunotherapy, which was given emergency use authorization by the Food and Drug Administration in August 2020, is within 60 days of the onset of symptoms, according to a new study. The research also reveals that the ideal convalescent plasma donor is a recovered COVID-19 patient who is older than 30 and whose illness had been severe.
Full Article
Oct 31, 2019
Malaria parasite lives on the edge
The parasite that causes malaria expresses genes that code for the proteins it will need in later life stages, using two separate schemes to prevent these proteins from actually being made until they are needed, according to new research.
Full Article
Jan 31, 2019
Male birth control for the malaria parasite
Full Article