Bio
Our laboratory couples molecular parasitology and structural biology to study the malaria parasite (Plasmodium spp.).
Huck Graduate Students
Publication Tags
Parasites Plasmodium Malaria Proteins Sporozoites Proteomics Genes Salivary Glands Liver Clustered Regularly Interspaced Short Palindromic Repeats Plasmodium Yoelii Plasmodium Falciparum Infection Rna Binding Proteins Messenger Rna Rodentia Culicidae Plasmodium Vivax Proteome Rna Gene Editing Glutamate Trna Ligase Enzymes Catalytic Rna 5 Aminopyrazole
Most Recent Papers
Protein-RNA interactions important for Plasmodium transmission
Kelly T. Rios, Scott E. Lindner, 2019, PLoS pathogens on p. e1008095
Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites
Scott E. Lindner, Kristian E. Swearingen, Melanie J. Shears, Michael P. Walker, Erin N. Vrana, Kevin J. Hart, Allen M. Minns, Photini Sinnis, Robert L. Moritz, Stefan H.I. Kappe, 2019, Nature communications
Cutting back malaria
Marcus C.S. Lee, Scott E. Lindner, Jose Juan Lopez-Rubio, Manuel Llinás, 2019, Briefings in functional genomics on p. 281-289
Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malaria
Ivo Muller, Aaron R. Jex, Stefan H.I. Kappe, Sebastian A. Mikolajczak, Jetsumon Sattabongkot, Rapatbhorn Patrapuvich, Scott Eugene Lindner, Erika L. Flannery, Cristian Koepfli, Brendan Ansell, Anita Lerch, Samantha J. Emery-Corbin, Sarah Charnaud, Jeffrey Smith, Nicolas Merrienne, Kristian E. Swearingen, Robert L. Moritz, Michaela Petter, Michael F. Duffy, Vorada Chuenchob, 2019, International Journal for Parasitology on p. 501-513
Plasmodium male gametocyte development and transmission are critically regulated by the two putative deadenylases of the CAF1/CCR4/NOT complex
Kevin J. Hart, Jenna Oberstaller, Michael P. Walker, Allen M. Minns, Mark F. Kennedy, Ian Padykula, John H. Adams, Scott E. Lindner, 2019, PLoS pathogens
Ribozyme-mediated, multiplex CRISPR gene editing and CRISPR interference (CRISPRi) in rodent-infectious Plasmodium yoelii
Michael P. Walker, Scott Eugene Lindner, 2019, Journal of Biological Chemistry on p. 9555-9566
Plasmodium Parasites Viewed through Proteomics
Kristian E. Swearingen, Scott E. Lindner, 2018, Trends in Parasitology
Th1-like Plasmodium-Specific Memory CD4<sup>+</sup> T Cells Support Humoral Immunity
Ryan A. Zander, Rahul Vijay, Angela D. Pack, Jenna J. Guthmiller, Amy C. Graham, Scott Eugene Lindner, Ashley M. Vaughan, Stefan H.I. Kappe, Noah S. Butler, 2018, Cell Reports
Nuclear, cytosolic, and surface-localized poly(A)-binding proteins of Plasmodium yoelii
Allen M. Minns, Kevin J. Hart, Suriyasri Subramanian, Susan Hafenstein, Scott E. Lindner, 2018, mSphere
5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents
Wenlin Huang, Matthew A. Hulverson, Zhongsheng Zhang, Ryan Choi, Kevin J. Hart, Mark Kennedy, Rama Subba Rao Vidadala, Dustin J. Maly, Wesley C. Van Voorhis, Scott E. Lindner, Erkang Fan, Kayode K. Ojo, 2016, Bioorganic and Medicinal Chemistry Letters on p. 5487-5491
Recent Most-Cited Papers
Total and putative surface proteomics of malaria parasite salivary gland sporozoites
Scott E. Lindner, Kristian E. Swearingen, Anke Harupa, Ashley M. Vaughan, Photini Sinnis, Robert L. Moritz, Stefan H.I. Kappe, 2013, Molecular and Cellular Proteomics on p. 1127-1143
Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice
Sebastian A. Mikolajczak, Ashley M. Vaughan, Niwat Kangwanrangsan, Wanlapa Roobsoong, Matthew Fishbaugher, Narathatai Yimamnuaychok, Nastaran Rezakhani, Viswanathan Lakshmanan, Naresh Singh, Alexis Kaushansky, Nelly Camargo, Michael Baldwin, Scott E. Lindner, John H. Adams, Jetsumon Sattabongkot, Stefan H.I. Kappe, 2015, Cell Host and Microbe on p. 526-535
A rapid and scalable density gradient purification method for Plasmodium sporozoites
Mark Kennedy, Matthew E. Fishbaugher, Ashley M. Vaughan, Rapatbhorn Patrapuvich, Rachasak Boonhok, Narathatai Yimamnuaychok, Nastaran Rezakhani, Peter Metzger, Marisa Ponpuak, Jetsumon Sattabongkot, Stefan H. Kappe, Jen Cc Hume, Scott E. Lindner, 2012, Malaria journal
Structural Determinants of DNA Binding by a P. falciparum ApiAP2 Transcriptional Regulator
Scott Eugene Lindner, Erandi K. De Silva, James L. Keck, Manuel Llinas, 2010, Journal of Molecular Biology on p. 558-567
Perturbations of PlasmodiumPuf2 expression and RNA-seq of Puf2-deficient sporozoites reveal a critical role in maintaining RNA homeostasis and parasite transmissibility
Scott Eugene Lindner, Sebastian A. Mikolajczak, Ashley M. Vaughan, Wonjong Moon, Brad R. Joyce, William J. Sullivan, Stefan H I Kappe, 2013, Cellular Microbiology on p. 1266-1283
A transgenic Plasmodium falciparum NF54 strain that expresses GFP-luciferase throughout the parasite life cycle
Ashley M. Vaughan, Sebastian A. Mikolajczak, Nelly Camargo, Viswanathan Lakshmanan, Mark Kennedy, Scott Eugene Lindner, Jessica L. Miller, Jen C.C. Hume, Stefan H.I. Kappe, 2012, Molecular and biochemical parasitology on p. 143-147
Translational regulation during stage transitions in malaria parasites
Liwang Cui, Scott Eugene Lindner, Jun Miao, 2015, Annals of the New York Academy of Sciences on p. 1-9
A bioinformatic survey of RNA-binding proteins in Plasmodium
BP Niranjan Reddy, Sony Shrestha, Kevin J. Hart, Xiaoying Liang, Karen Kemirembe, Liwang Cui, Scott E. Lindner, 2015, BMC genomics
A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast
Boniface M. Mailu, Gowthaman Ramasamay, Devaraja G. Mudeppa, Ling Li, Scott E. Lindner, Megan J. Peterson, Amy E. DeRocher, Stefan H.I. Kappe, Pradipsinh K. Rathod, Malcolm J. Gardner, 2013, Journal of Biological Chemistry on p. 32539-32552
Plasmodium yoelii inhibitor of cysteine proteases is exported to exomembrane structures and interacts with yoelipain-2 during asexual blood-stage development
Ying Pei, Jessica L. Miller, Scott E. Lindner, Ashley M. Vaughan, Motomi Torii, Stefan H.I. Kappe, 2013, Cellular Microbiology on p. 1508-1526