Scott Lindner
Associate Professor of Biochemistry & Molecular Biology, Co-Director, Center for Malaria Research
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W230B Millennium Science Complex
University Park, PA 16802 - He/Him
- sel27@psu.edu
- (814) 867-4062
Research Summary
Our laboratory couples molecular parasitology and structural biology to study the malaria parasite (Plasmodium spp.).
Huck Graduate Students
Huck Affiliations
- Center for Infectious Disease Dynamics
- Molecular, Cellular, and Integrative Biosciences
- Center for RNA Molecular Biology
- Center for Malaria Research
- Center for Structural Biology
Links
Publication Tags
Parasites Malaria Sporozoites Proteins Plasmodium Liver Proteomics Genes Culicidae Infection Salivary Glands Clustered Regularly Interspaced Short Palindromic Repeats Rodentia Messenger Rna Plasmodium Falciparum Plasmodium Yoelii Viruses Gene Editing Neutralizing Antibodies Rna Binding Proteins Life Cycle Stages Plasmodium Vivax Proteome Immunotherapy Catalytic RnaMost Recent Papers
Limited window for donation of convalescent plasma with high live-virus neutralizing antibody titers for COVID-19 immunotherapy
Abhinay Gontu, Sreenidhi Srinivasan, Eric Salazar, Meera Surendran Nair, Ruth H. Nissly, Denver Greenawalt, Ian M. Bird, Catherine M. Herzog, Matthew J. Ferrari, Indira Poojary, Robab Katani, Scott E. Lindner, Allen M. Minns, Randall Rossi, Paul A. Christensen, Brian Castillo, Jian Chen, Todd N. Eagar, Xin Yi, Picheng Zhao, Christopher Leveque, Randall J. Olsen, David W. Bernard, Jimmy Gollihar, Suresh V. Kuchipudi, James M. Musser, Vivek Kapur, 2021, Communications Biology
Definition of constitutive and stage-enriched promoters in the rodent malaria parasite, Plasmodium yoelii
Laura M. Bowman, Logan E. Finger, Kevin J. Hart, Scott E. Lindner, 2020, Malaria Journal
Determination of human identity from Anopheles stephensi mosquito blood meals using direct amplification and massively parallel sequencing
Shayna L. Gray, Teresa M. Tiedge, Joann M. Butkus, Tyler J. Earp, Scott E. Lindner, Reena Roy, 2020, Forensic Science International: Genetics
Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites
Scott E. Lindner, Kristian E. Swearingen, Melanie J. Shears, Michael P. Walker, Erin N. Vrana, Kevin J. Hart, Allen M. Minns, Photini Sinnis, Robert L. Moritz, Stefan H.I. Kappe, 2019, Nature Communications
Cutting back malaria: CRISPR/Cas9 genome editing of plasmodium
Marcus C.S. Lee, Scott E. Lindner, Jose Juan Lopez-Rubio, Manuel Llinás, 2019, Briefings in Functional Genomics on p. 281-289
Ribozyme-mediated, multiplex CRISPR gene editing and CRISPR interference (CRISPRi) in rodent-infectious Plasmodium yoelii
Michael P. Walker, Scott E. Lindner, 2019, Journal of Biological Chemistry on p. 9555-9566
Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malaria
Ivo Muller, Aaron R. Jex, Stefan H.I. Kappe, Sebastian A. Mikolajczak, Jetsumon Sattabongkot, Rapatbhorn Patrapuvich, Scott Lindner, Erika L. Flannery, Cristian Koepfli, Brendan Ansell, Anita Lerch, Samantha J. Emery-Corbin, Sarah Charnaud, Jeffrey Smith, Nicolas Merrienne, Kristian E. Swearingen, Robert L. Moritz, Michaela Petter, Michael F. Duffy, Vorada Chuenchob, 2019, International Journal for Parasitology on p. 501-513
Plasmodium male gametocyte development and transmission are critically regulated by the two putative deadenylases of the CAF1/CCR4/NOT complex
Kevin J. Hart, Jenna Oberstaller, Michael P. Walker, Allen M. Minns, Mark F. Kennedy, Ian Padykula, John H. Adams, Scott E. Lindner, 2019, PLoS Pathogens
Protein-RNA interactions important for plasmodium transmission
Kelly T. Rios, Scott E. Lindner, 2019, PLoS Pathogens
A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum
Sandra Bennink, Andreas von Bohl, Che J. Ngwa, Leonie Henschel, Andrea Kuehn, Nicole Pilch, Tim Weißbach, Alina N. Rosinski, Matthias Scheuermayer, Urska Repnik, Jude M. Przyborski, Allen M. Minns, Lindsey M. Orchard, Gareth Griffiths, Scott Eugene Lindner, Manuel Llinas, Gabriele Pradel, 2018, PLoS Pathogens
Most-Cited Papers
Total and putative surface proteomics of malaria parasite salivary gland sporozoites
Scott E. Lindner, Kristian E. Swearingen, Anke Harupa, Ashley M. Vaughan, Photini Sinnis, Robert L. Moritz, Stefan H.I. Kappe, 2013, Molecular and Cellular Proteomics on p. 1127-1143
Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice
Sebastian A. Mikolajczak, Ashley M. Vaughan, Niwat Kangwanrangsan, Wanlapa Roobsoong, Matthew Fishbaugher, Narathatai Yimamnuaychok, Nastaran Rezakhani, Viswanathan Lakshmanan, Naresh Singh, Alexis Kaushansky, Nelly Camargo, Michael Baldwin, Scott E. Lindner, John H. Adams, Jetsumon Sattabongkot, Stefan H.I. Kappe, 2015, Cell Host and Microbe on p. 526-535
Interrogating the Plasmodium Sporozoite Surface
Kristian E. Swearingen, Scott E. Lindner, Lirong Shi, Melanie J. Shears, Anke Harupa, Christine S. Hopp, Ashley M. Vaughan, Timothy A. Springer, Robert L. Moritz, Stefan H.I. Kappe, Photini Sinnis, 2016, PLoS Pathogens
A rapid and scalable density gradient purification method for Plasmodium sporozoites
Mark Kennedy, Matthew E. Fishbaugher, Ashley M. Vaughan, Rapatbhorn Patrapuvich, Rachasak Boonhok, Narathatai Yimamnuaychok, Nastaran Rezakhani, Peter Metzger, Marisa Ponpuak, Jetsumon Sattabongkot, Stefan H. Kappe, Jen Cc Hume, Scott E. Lindner, 2012, Malaria Journal
Malaria parasite pre-erythrocytic infection
Scott E. Lindner, Jessica L. Miller, Stefan H.I. Kappe, 2012, Cellular Microbiology on p. 316-324
Perturbations of PlasmodiumPuf2 expression and RNA-seq of Puf2-deficient sporozoites reveal a critical role in maintaining RNA homeostasis and parasite transmissibility
Scott Eugene Lindner, Sebastian A. Mikolajczak, Ashley M. Vaughan, Wonjong Moon, Brad R. Joyce, William J. Sullivan, Stefan H I Kappe, 2013, Cellular Microbiology on p. 1266-1283
A transgenic Plasmodium falciparum NF54 strain that expresses GFP-luciferase throughout the parasite life cycle
Ashley M. Vaughan, Sebastian A. Mikolajczak, Nelly Camargo, Viswanathan Lakshmanan, Mark Kennedy, Scott Eugene Lindner, Jessica L. Miller, Jen C.C. Hume, Stefan H.I. Kappe, 2012, Molecular and Biochemical Parasitology on p. 143-147
SAP1 is a critical post-transcriptional regulator of infectivity in malaria parasite sporozoite stages
Ahmed S I Aly, Scott Eugene Lindner, Drew C. MacKellar, Xinxia Peng, Stefan H I Kappe, 2011, Molecular Microbiology on p. 929-939
Translational regulation during stage transitions in malaria parasites
Liwang Cui, Scott Lindner, Jun Miao, 2015, Annals of the New York Academy of Sciences on p. 1-9
A bioinformatic survey of RNA-binding proteins in Plasmodium
BP Niranjan Reddy, Sony Shrestha, Kevin J. Hart, Xiaoying Liang, Karen Kemirembe, Liwang Cui, Scott E. Lindner, 2015, BMC Genomics
News Articles Featuring Scott Lindner
Feb 25, 2021
Study finds short window for donating convalescent plasma to COVID-19 patients
The optimal timeframe for donating convalescent plasma for use in COVID-19 immunotherapy, which was given emergency-use authorization by the Food and Drug Administration in August 2020, is within 60 days of the onset of symptoms, according to a new Penn State-led study.
Full Article
Feb 25, 2021
Study finds short window for donating convalescent plasma to COVID-19 patients
The optimal timeframe for donating convalescent plasma for use in COVID-19 immunotherapy, which was given emergency use authorization by the Food and Drug Administration in August 2020, is within 60 days of the onset of symptoms, according to a new study. The research also reveals that the ideal convalescent plasma donor is a recovered COVID-19 patient who is older than 30 and whose illness had been severe.
Full Article
Oct 31, 2019
Malaria parasite lives on the edge
The parasite that causes malaria expresses genes that code for the proteins it will need in later life stages, using two separate schemes to prevent these proteins from actually being made until they are needed, according to new research.
Full Article
Jan 31, 2019
Male birth control for the malaria parasite
Full Article