Scott Lindner

Associate Professor of Biochemistry & Molecular Biology, Co-Director, Center for Malaria Research

Scott Lindner

Research Summary

Our laboratory couples molecular parasitology and structural biology to study the malaria parasite (Plasmodium spp.).

Huck Graduate Students

Huck Affiliations


Publication Tags

Parasites Malaria Sporozoites Proteins Plasmodium Liver Proteomics Salivary Glands Infection Infections Genes Culicidae Clustered Regularly Interspaced Short Palindromic Repeats Rodentia Viruses Plasmodium Vivax Proteome Neutralizing Antibodies Gene Editing Messenger Rna Plasmodium Yoelii Protein Rna Binding Proteins Plasmodium Falciparum Life Cycle Stages

Most Recent Papers

Limited window for donation of convalescent plasma with high live-virus neutralizing antibody titers for COVID-19 immunotherapy

Abhinay Gontu, Sreenidhi Srinivasan, Eric Salazar, Meera Surendran Nair, Ruth H. Nissly, Denver Greenawalt, Ian M. Bird, Catherine M. Herzog, Matthew J. Ferrari, Indira Poojary, Robab Katani, Scott E. Lindner, Allen M. Minns, Randall Rossi, Paul A. Christensen, Brian Castillo, Jian Chen, Todd N. Eagar, Xin Yi, Picheng Zhao, Christopher Leveque, Randall J. Olsen, David W. Bernard, Jimmy Gollihar, Suresh V. Kuchipudi, James M. Musser, Vivek Kapur, 2021, Communications Biology

The Plasmodium NOT1-G paralogue is an essential regulator of sexual stage maturation and parasite transmission

Kevin J. Hart, B. Joanne Power, Kelly T. Rios, Aswathy Sebastian, Scott E. Lindner, 2021, PLoS Biology

Monoclonal antibodies to s and n sars-cov-2 proteins as probes to assess structural and antigenic properties of coronaviruses

Rinki Kumar, Neil D. Christensen, Rebecca J. Kaddis Maldonado, Maria C. Bewley, Alexandria Ostman, Malgorzata Sudol, Eunice C. Chen, Natalie W. Buchkovich, Abhinay Gontu, Meera Surendran Nair, Ruth H. Nissly, Allen M. Minns, Vivek Kapur, Randall Rossi, Suresh V. Kuchipudi, Scott E. Lindner, Leslie J. Parent, John M. Flanagan, Nicholas J. Buchkovich, 2021, Viruses

Definition of constitutive and stage-enriched promoters in the rodent malaria parasite, Plasmodium yoelii

Laura M. Bowman, Logan E. Finger, Kevin J. Hart, Scott E. Lindner, 2020, Malaria Journal

Determination of human identity from Anopheles stephensi mosquito blood meals using direct amplification and massively parallel sequencing

Shayna L. Gray, Teresa M. Tiedge, Joann M. Butkus, Tyler J. Earp, Scott E. Lindner, Reena Roy, 2020, Forensic Science International: Genetics

Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

Scott E. Lindner, Kristian E. Swearingen, Melanie J. Shears, Michael P. Walker, Erin N. Vrana, Kevin J. Hart, Allen M. Minns, Photini Sinnis, Robert L. Moritz, Stefan H.I. Kappe, 2019, Nature Communications

Cutting back malaria: CRISPR/Cas9 genome editing of plasmodium

Marcus C.S. Lee, Scott E. Lindner, Jose Juan Lopez-Rubio, Manuel Llinás, 2019, Briefings in Functional Genomics on p. 281-289

Ribozyme-mediated, multiplex CRISPR gene editing and CRISPR interference (CRISPRi) in rodent-infectious Plasmodium yoelii

Michael P. Walker, Scott E. Lindner, 2019, Journal of Biological Chemistry on p. 9555-9566

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malaria

Ivo Muller, Aaron R. Jex, Stefan H.I. Kappe, Sebastian A. Mikolajczak, Jetsumon Sattabongkot, Rapatbhorn Patrapuvich, Scott Lindner, Erika L. Flannery, Cristian Koepfli, Brendan Ansell, Anita Lerch, Samantha J. Emery-Corbin, Sarah Charnaud, Jeffrey Smith, Nicolas Merrienne, Kristian E. Swearingen, Robert L. Moritz, Michaela Petter, Michael F. Duffy, Vorada Chuenchob, 2019, International Journal for Parasitology on p. 501-513

Plasmodium male gametocyte development and transmission are critically regulated by the two putative deadenylases of the CAF1/CCR4/NOT complex

Kevin J. Hart, Jenna Oberstaller, Michael P. Walker, Allen M. Minns, Mark F. Kennedy, Ian Padykula, John H. Adams, Scott E. Lindner, 2019, PLoS Pathogens

Most-Cited Papers

Total and putative surface proteomics of malaria parasite salivary gland sporozoites

Scott E. Lindner, Kristian E. Swearingen, Anke Harupa, Ashley M. Vaughan, Photini Sinnis, Robert L. Moritz, Stefan H.I. Kappe, 2013, Molecular and Cellular Proteomics on p. 1127-1143

Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice

Sebastian A. Mikolajczak, Ashley M. Vaughan, Niwat Kangwanrangsan, Wanlapa Roobsoong, Matthew Fishbaugher, Narathatai Yimamnuaychok, Nastaran Rezakhani, Viswanathan Lakshmanan, Naresh Singh, Alexis Kaushansky, Nelly Camargo, Michael Baldwin, Scott E. Lindner, John H. Adams, Jetsumon Sattabongkot, Stefan H.I. Kappe, 2015, Cell Host and Microbe on p. 526-535

Interrogating the Plasmodium Sporozoite Surface

Kristian E. Swearingen, Scott E. Lindner, Lirong Shi, Melanie J. Shears, Anke Harupa, Christine S. Hopp, Ashley M. Vaughan, Timothy A. Springer, Robert L. Moritz, Stefan H.I. Kappe, Photini Sinnis, 2016, PLoS Pathogens

A rapid and scalable density gradient purification method for Plasmodium sporozoites

Mark Kennedy, Matthew E. Fishbaugher, Ashley M. Vaughan, Rapatbhorn Patrapuvich, Rachasak Boonhok, Narathatai Yimamnuaychok, Nastaran Rezakhani, Peter Metzger, Marisa Ponpuak, Jetsumon Sattabongkot, Stefan H. Kappe, Jen Cc Hume, Scott E. Lindner, 2012, Malaria Journal

Malaria parasite pre-erythrocytic infection: Preparation meets opportunity

Scott E. Lindner, Jessica L. Miller, Stefan H.I. Kappe, 2012, Cellular Microbiology on p. 316-324

Perturbations of PlasmodiumPuf2 expression and RNA-seq of Puf2-deficient sporozoites reveal a critical role in maintaining RNA homeostasis and parasite transmissibility

Scott E. Lindner, Sebastian A. Mikolajczak, Ashley M. Vaughan, Wonjong Moon, Brad R. Joyce, William J. Sullivan, Stefan H.I. Kappe, 2013, Cellular Microbiology on p. 1266-1283

A transgenic Plasmodium falciparum NF54 strain that expresses GFP-luciferase throughout the parasite life cycle

Ashley M. Vaughan, Sebastian A. Mikolajczak, Nelly Camargo, Viswanathan Lakshmanan, Mark Kennedy, Scott E. Lindner, Jessica L. Miller, Jen C.C. Hume, Stefan H.I. Kappe, 2012, Molecular and Biochemical Parasitology on p. 143-147

Translational regulation during stage transitions in malaria parasites

Liwang Cui, Scott Lindner, Jun Miao, 2015, Annals of the New York Academy of Sciences on p. 1-9

A bioinformatic survey of RNA-binding proteins in Plasmodium

BP Niranjan Reddy, Sony Shrestha, Kevin J. Hart, Xiaoying Liang, Karen Kemirembe, Liwang Cui, Scott E. Lindner, 2015, BMC Genomics

Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodium vivax salivary gland sporozoites

Kristian E. Swearingen, Scott E. Lindner, Erika L. Flannery, Ashley M. Vaughan, Robert D. Morrison, Rapatbhorn Patrapuvich, Cristian Koepfli, Ivo Muller, Aaron Jex, Robert L. Moritz, Stefan H.I. Kappe, Jetsumon Sattabongkot, Sebastian A. Mikolajczak, 2017, PLoS Neglected Tropical Diseases