Scott Lindner

Associate Professor of Biochemistry & Molecular Biology, Co-Director, Center for Malaria Research

Scott Lindner

Research Summary

Our laboratory couples molecular parasitology and structural biology to study the malaria parasite (Plasmodium spp.).

Graduate Students

Huck Affiliations


Publication Tags

Parasites Malaria Sporozoites Plasmodium Proteins Proteomics Salivary Glands Genes Liver Clustered Regularly Interspaced Short Palindromic Repeats Culicidae Infection Plasmodium Yoelii Messenger Rna Rodentia Plasmodium Falciparum Rna Binding Proteins Plasmodium Vivax Proteome Rna Life Cycle Stages Gene Editing Catalytic Rna Histones Mass Spectrometry

Most Recent Papers

Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

Scott E. Lindner, Kristian E. Swearingen, Melanie J. Shears, Michael P. Walker, Erin N. Vrana, Kevin J. Hart, Allen M. Minns, Photini Sinnis, Robert L. Moritz, Stefan H.I. Kappe, 2019, Nature communications

Protein-RNA interactions important for Plasmodium transmission

Kelly T. Rios, Scott E. Lindner, 2019, PLoS pathogens on p. e1008095

Cutting back malaria

Marcus C.S. Lee, Scott E. Lindner, Jose Juan Lopez-Rubio, Manuel Llinás, 2019, Briefings in functional genomics on p. 281-289

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malaria

Ivo Muller, Aaron R. Jex, Stefan H.I. Kappe, Sebastian A. Mikolajczak, Jetsumon Sattabongkot, Rapatbhorn Patrapuvich, Scott Eugene Lindner, Erika L. Flannery, Cristian Koepfli, Brendan Ansell, Anita Lerch, Samantha J. Emery-Corbin, Sarah Charnaud, Jeffrey Smith, Nicolas Merrienne, Kristian E. Swearingen, Robert L. Moritz, Michaela Petter, Michael F. Duffy, Vorada Chuenchob, 2019, International Journal for Parasitology on p. 501-513

Plasmodium male gametocyte development and transmission are critically regulated by the two putative deadenylases of the CAF1/CCR4/NOT complex

Kevin J. Hart, Jenna Oberstaller, Michael P. Walker, Allen M. Minns, Mark F. Kennedy, Ian Padykula, John H. Adams, Scott E. Lindner, 2019, PLoS pathogens

Ribozyme-mediated, multiplex CRISPR gene editing and CRISPR interference (CRISPRi) in rodent-infectious Plasmodium yoelii

Michael P. Walker, Scott Eugene Lindner, 2019, Journal of Biological Chemistry on p. 9555-9566

A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum

Sandra Bennink, Andreas von Bohl, Che J. Ngwa, Leonie Henschel, Andrea Kuehn, Nicole Pilch, Tim Weißbach, Alina N. Rosinski, Matthias Scheuermayer, Urska Repnik, Jude M. Przyborski, Allen M. Minns, Lindsey M. Orchard, Gareth Griffiths, Scott Eugene Lindner, Manuel Llinas, Gabriele Pradel, 2018, PLoS Pathogens

cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses

William O. Hahn, Noah S. Butler, Scott Eugene Lindner, Holly M. Akilesh, D. Noah Sather, Stefan Hi Kappe, Jessica A. Hamerman, Michael Gale, W. Conrad Liles, Marion Pepper, 2018, JCI insight

Plasmodium Parasites Viewed through Proteomics

Kristian E. Swearingen, Scott E. Lindner, 2018, Trends in Parasitology

Nuclear, cytosolic, and surface-localized poly(A)-binding proteins of Plasmodium yoelii

Allen M. Minns, Kevin J. Hart, Suriyasri Subramanian, Susan Hafenstein, Scott E. Lindner, 2018, mSphere

Most-Cited Papers

Total and putative surface proteomics of malaria parasite salivary gland sporozoites

Scott E. Lindner, Kristian E. Swearingen, Anke Harupa, Ashley M. Vaughan, Photini Sinnis, Robert L. Moritz, Stefan H.I. Kappe, 2013, Molecular and Cellular Proteomics on p. 1127-1143

Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice

Sebastian A. Mikolajczak, Ashley M. Vaughan, Niwat Kangwanrangsan, Wanlapa Roobsoong, Matthew Fishbaugher, Narathatai Yimamnuaychok, Nastaran Rezakhani, Viswanathan Lakshmanan, Naresh Singh, Alexis Kaushansky, Nelly Camargo, Michael Baldwin, Scott E. Lindner, John H. Adams, Jetsumon Sattabongkot, Stefan H.I. Kappe, 2015, Cell Host and Microbe on p. 526-535

Interrogating the Plasmodium Sporozoite Surface

Kristian E. Swearingen, Scott E. Lindner, Lirong Shi, Melanie J. Shears, Anke Harupa, Christine S. Hopp, Ashley M. Vaughan, Timothy A. Springer, Robert L. Moritz, Stefan H.I. Kappe, Photini Sinnis, 2016, PLoS Pathogens

A rapid and scalable density gradient purification method for Plasmodium sporozoites

Mark Kennedy, Matthew E. Fishbaugher, Ashley M. Vaughan, Rapatbhorn Patrapuvich, Rachasak Boonhok, Narathatai Yimamnuaychok, Nastaran Rezakhani, Peter Metzger, Marisa Ponpuak, Jetsumon Sattabongkot, Stefan H. Kappe, Jen Cc Hume, Scott E. Lindner, 2012, Malaria journal

Structural Determinants of DNA Binding by a P. falciparum ApiAP2 Transcriptional Regulator

Scott Eugene Lindner, Erandi K. De Silva, James L. Keck, Manuel Llinas, 2010, Journal of Molecular Biology on p. 558-567

Perturbations of PlasmodiumPuf2 expression and RNA-seq of Puf2-deficient sporozoites reveal a critical role in maintaining RNA homeostasis and parasite transmissibility

Scott Eugene Lindner, Sebastian A. Mikolajczak, Ashley M. Vaughan, Wonjong Moon, Brad R. Joyce, William J. Sullivan, Stefan H I Kappe, 2013, Cellular Microbiology on p. 1266-1283

A transgenic Plasmodium falciparum NF54 strain that expresses GFP-luciferase throughout the parasite life cycle

Ashley M. Vaughan, Sebastian A. Mikolajczak, Nelly Camargo, Viswanathan Lakshmanan, Mark Kennedy, Scott Eugene Lindner, Jessica L. Miller, Jen C.C. Hume, Stefan H.I. Kappe, 2012, Molecular and biochemical parasitology on p. 143-147

Catalytic activation of histone acetyltransferase Rtt109 by a histone chaperone

Erin M. Kolonko, Brittany N. Albaugh, Scott E. Lindner, Yuanyuan Chen, Kenneth A. Satyshur, Kevin M. Arnold, Paul D. Kaufman, James L. Keck, John M. Denu, 2010, Proceedings of the National Academy of Sciences of the United States of America on p. 20275-20280

SAP1 is a critical post-transcriptional regulator of infectivity in malaria parasite sporozoite stages

Ahmed S I Aly, Scott Eugene Lindner, Drew C. MacKellar, Xinxia Peng, Stefan H I Kappe, 2011, Molecular Microbiology on p. 929-939

Translational regulation during stage transitions in malaria parasites

Liwang Cui, Scott Eugene Lindner, Jun Miao, 2015, Annals of the New York Academy of Sciences on p. 1-9