Joyce Jose

Assistant Professor of Biochemistry & Molecular Biology

Joyce Jose

Research Summary

Virus-host interactions involved in the pathogenesis of alphaviruses and flaviviruses. Analysis of virus induced structures and cytoskeletal modifications in mammalian host and insect vector using high-resolution live cell imaging and electron microscopy. Viral determinants of neurotropism, encephalitis, transmission and persistence in BSL-3 pathogens.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Proteins Alphavirus Viruses Antiviral Agents Human Genome Heparin Angiotensin Converting Enzyme 2 Heparitin Sulfate Ribonucleotides Glycoproteins Sindbis Virus Protein Genome Lipids Virus Diseases Sars Virus Cytidine Triphosphate Infection Membranes Culicidae Infections Neutralizing Antibodies Acetylglucosamine Polysaccharides Nucleocapsid

Most Recent Papers

A Chemical Strategy for Intracellular Arming of an Endogenous Broad-Spectrum Antiviral Nucleotide

Kellan Passow, Haley Caldwell, Kiet Ngo, Jamie JArnold, Nicole Antczak, Anoop Narayanan, Joyce Jose, Shana Sturla, Craig Cameron, Alexander Ciota, D Harki, 2021, Journal of Medicinal Chemistry

Alphavirus-induced membrane rearrangements during replication, assembly, and budding

Zeinab Elmasri, Benjamin L. Nasal, Joyce Jose, 2021, Pathogens

A synthetic defective interfering SARS-CoV-2

Shun Yao, Anoop Narayanan, Sydney A. Majowicz, Joyce Jose, Marco Archetti, 2021, PeerJ

Identification of a pocket factor that is critical to Zika virus assembly

Nadia M. DiNunno, Daniel J. Goetschius, Anoop Narayanan, Sydney A. Majowicz, Ibrahim Moustafa, Carol M. Bator, Susan L. Hafenstein, Joyce Jose, 2020, Nature Communications

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

Thomas Mandel Clausen, Daniel R. Sandoval, Charlotte B. Spliid, Jessica Pihl, Hailee R. Perrett, Chelsea D. Painter, Anoop Narayanan, Sydney A. Majowicz, Elizabeth M. Kwong, Rachael N. McVicar, Bryan E. Thacker, Charles A. Glass, Zhang Yang, Jonathan L. Torres, Gregory J. Golden, Phillip L. Bartels, Ryan N. Porell, Aaron F. Garretson, Logan Laubach, Jared Feldman, Xin Yin, Yuan Pu, Blake M. Hauser, Timothy M. Caradonna, Benjamin P. Kellman, Cameron Martino, Philip L.S.M. Gordts, Sumit K. Chanda, Aaron G. Schmidt, Kamil Godula, Sandra L. Leibel, Joyce Jose, Kevin D. Corbett, Andrew B. Ward, Aaron F. Carlin, Jeffrey D. Esko, 2020, Cell on p. 1043-1057.e15

Author Correction

Anthony S. Gizzi, Tyler L. Grove, Jamie J. Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig E. Cameron, Steven C. Almo, 2020, Nature on p. E15

Glycan-dependent chikungunya viral infection divulged by antiviral activity of NAG specific chi-like lectin

Ramanjit Kaur, Neetu, Rajat Mudgal, Joyce Jose, Pravindra Kumar, Shailly Tomar, 2019, Virology on p. 91-98

Erratum to

Anthony S. Gizzi, Tyler L. Grove, Jamie J. Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig E. Cameron, Steven C. Almo, 2018, Nature on p. E3

A naturally occurring antiviral ribonucleotide encoded by the human genome

Anthony S. Gizzi, Tyler L. Grove, Jamie J. Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig E. Cameron, Steven C. Almo, 2018, Nature on p. 610-614

Spatial and temporal analysis of alphavirus replication and assembly in mammalian and mosquito cells

Joyce Jose, Aaron B. Taylor, Richard J. Kuhn, 2017, mBio

Most-Cited Papers

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

Thomas Mandel Clausen, Daniel R. Sandoval, Charlotte B. Spliid, Jessica Pihl, Hailee R. Perrett, Chelsea D. Painter, Anoop Narayanan, Sydney A. Majowicz, Elizabeth M. Kwong, Rachael N. McVicar, Bryan E. Thacker, Charles A. Glass, Zhang Yang, Jonathan L. Torres, Gregory J. Golden, Phillip L. Bartels, Ryan N. Porell, Aaron F. Garretson, Logan Laubach, Jared Feldman, Xin Yin, Yuan Pu, Blake M. Hauser, Timothy M. Caradonna, Benjamin P. Kellman, Cameron Martino, Philip L.S.M. Gordts, Sumit K. Chanda, Aaron G. Schmidt, Kamil Godula, Sandra L. Leibel, Joyce Jose, Kevin D. Corbett, Andrew B. Ward, Aaron F. Carlin, Jeffrey D. Esko, 2020, Cell on p. 1043-1057.e15

Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system

David L. Akey, W. Clay Brown, Somnath Dutta, Jamie Konwerski, Joyce Jose, Thomas J. Jurkiw, James DelProposto, Craig M. Ogata, Georgios Skiniotis, Richard J. Kuhn, Janet L. Smith, 2014, Science on p. 881-885

A naturally occurring antiviral ribonucleotide encoded by the human genome

Anthony S. Gizzi, Tyler L. Grove, Jamie J. Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig E. Cameron, Steven C. Almo, 2018, Nature on p. 610-614

Functional characterization of the alphavirus TF protein

Jonathan E. Snyder, Kirsten A. Kulcsar, Kimberly L.W. Schultz, Catherine P. Riley, Jacob T. Neary, Scott Marr, Joyce Jose, Diane E. Griffin, Richard R. Kuhn, 2013, Journal of Virology on p. 8511-8523

Locking and blocking the viral landscape of an alphavirus with neutralizing antibodies

Jason Porta, Joyce Jose, John T. Roehrig, Carol D. Blair, Richard J. Kuhn, Michael G. Rossmann, 2014, Journal of Virology on p. 9616-9623

Interactions of the cytoplasmic domain of sindbis virus E2 with nucleocapsid cores promote alphavirus budding

Joyce Jose, Laralynne Przybyla, Thomas J. Edwards, Rushika Perera, John W. Burgner, Richard J. Kuhn, 2012, Journal of Virology on p. 2585-2599

Structure-guided insights on the role of NS1 in flavivirus infection

David L. Akey, W. Clay Brown, Joyce Jose, Richard J. Kuhn, Janet L. Smith, 2015, BioEssays on p. 489-494

Spatial and temporal analysis of alphavirus replication and assembly in mammalian and mosquito cells

Joyce Jose, Aaron B. Taylor, Richard J. Kuhn, 2017, mBio

Fluorescent protein-tagged sindbis virus E2 glycoprotein allows single particle analysis of virus budding from live cells

Joyce Jose, Jinghua Tang, Aaron B. Taylor, Timothy S. Baker, Richard J. Kuhn, 2015, Viruses on p. 6182-6199

Glycan-dependent chikungunya viral infection divulged by antiviral activity of NAG specific chi-like lectin

Ramanjit Kaur, Neetu, Rajat Mudgal, Joyce Jose, Pravindra Kumar, Shailly Tomar, 2019, Virology on p. 91-98