Joyce Jose
Assistant Professor of Biochemistry & Molecular Biology
-
W206 Millennium Science Complex
University Park, - jxj321@psu.edu
- (814) 863-8806
Research Summary
Virus-host interactions involved in the pathogenesis of alphaviruses and flaviviruses. Analysis of virus induced structures and cytoskeletal modifications in mammalian host and insect vector using high-resolution live cell imaging and electron microscopy. Viral determinants of neurotropism, encephalitis, transmission and persistence in BSL-3 pathogens.
Huck Graduate Students
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- Center for Infectious Disease Dynamics
- Center for Structural Biology
Links
Publication Tags
Proteins Viruses Alphavirus Antiviral Agents Sars Virus Heparin Angiotensin Converting Enzyme 2 Heparitin Sulfate Cells Glycoproteins Sindbis Virus Protein Genome Lipids Lycorine Drug Peptide Hydrolases Crystal Structure Membranes Infection Ion Channels Infections Antiviral Drug Protease Inhibitor AssaysMost Recent Publications
Structure-based inhibitor design and repurposing clinical drugs to target SARS-CoV-2 proteases
A Narayanan, Shay Toner, Joyce Jose, Biochemical Society Transactions
Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay
Anoop Narayanan, Manju Narwal, Sydney A. Majowicz, Carmine Varricchio, Shay A. Toner, Carlo Ballatore, Andrea Brancale, Katsuhiko S. Murakami, Joyce Jose, 2022, Communications Biology
Requirement of a functional ion channel for Sindbis virus glycoprotein transport, CPV-II formation, and efficient virus budding
Zeinab Elmasri, Vashi Negi, Richard J. Kuhn, Joyce Jose, 2022, PLoS Pathogens
Asymmetry in icosahedral viruses
Joyce Jose, Susan L. Hafenstein, 2022, Current Opinion in Virology
Structure-based inhibitor design and repurposing clinical drugs to target SARS-CoV-2 proteases
Anoop Narayanan, Shay A. Toner, Joyce Jose, 2022, Biochemical Society Transactions on p. 151-165
A Chemical Strategy for Intracellular Arming of an Endogenous Broad-Spectrum Antiviral Nucleotide
Kellan T. Passow, Haley S. Caldwell, Kiet A. Ngo, Jamie J. Arnold, Jamie JArnold, Nicole M. Antczak, Anoop Narayanan, Joyce Jose, Shana J. Sturla, Craig E. Cameron, Alexander Ciota, D Harki, 2021, Journal of Medicinal Chemistry on p. 15429-15439
Alphavirus-induced membrane rearrangements during replication, assembly, and budding
Zeinab Elmasri, Benjamin L. Nasal, Joyce Jose, 2021, Pathogens
A synthetic defective interfering SARS-CoV-2
Shun yao, Anoop Narayanan, Sydney Majowicz, Joyce Jose, Marco Archetti, 2021, PeerJ
Identification of a pocket factor that is critical to Zika virus assembly
Nadia M. DiNunno, Daniel J. Goetschius, Anoop Narayanan, Sydney A. Majowicz, Ibrahim Moustafa, Carol M. Bator, Susan L. Hafenstein, Joyce Jose, 2020, Nature Communications
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
Thomas Mandel Clausen, Daniel R. Sandoval, Charlotte B. Spliid, Jessica Pihl, Hailee R. Perrett, Chelsea D. Painter, Anoop Narayanan, Sydney A. Majowicz, Elizabeth M. Kwong, Rachael N. McVicar, Bryan E. Thacker, Charles A. Glass, Zhang Yang, Jonathan L. Torres, Gregory J. Golden, Phillip L. Bartels, Ryan N. Porell, Aaron F. Garretson, Logan Laubach, Jared Feldman, Xin Yin, Yuan Pu, Blake M. Hauser, Timothy M. Caradonna, Benjamin P. Kellman, Cameron Martino, Philip L.S.M. Gordts, Sumit K. Chanda, Aaron G. Schmidt, Kamil Godula, Sandra L. Leibel, Joyce Jose, Kevin D. Corbett, Andrew B. Ward, Aaron F. Carlin, Jeffrey D. Esko, 2020, Cell on p. 1043-1057.e15
Most-Cited Papers
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
Thomas Mandel Clausen, Daniel R. Sandoval, Charlotte B. Spliid, Jessica Pihl, Hailee R. Perrett, Chelsea D. Painter, Anoop Narayanan, Sydney A. Majowicz, Elizabeth M. Kwong, Rachael N. McVicar, Bryan E. Thacker, Charles A. Glass, Zhang Yang, Jonathan L. Torres, Gregory J. Golden, Phillip L. Bartels, Ryan N. Porell, Aaron F. Garretson, Logan Laubach, Jared Feldman, Xin Yin, Yuan Pu, Blake M. Hauser, Timothy M. Caradonna, Benjamin P. Kellman, Cameron Martino, Philip L.S.M. Gordts, Sumit K. Chanda, Aaron G. Schmidt, Kamil Godula, Sandra L. Leibel, Joyce Jose, Kevin D. Corbett, Andrew B. Ward, Aaron F. Carlin, Jeffrey D. Esko, 2020, Cell on p. 1043-1057.e15
Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system
David L. Akey, W. Clay Brown, Somnath Dutta, Jamie Konwerski, Joyce Jose, Thomas J. Jurkiw, James DelProposto, Craig M. Ogata, Georgios Skiniotis, Richard J. Kuhn, Janet L. Smith, 2014, Science on p. 881-885
A naturally occurring antiviral ribonucleotide encoded by the human genome
Anthony S. Gizzi, Tyler L. Grove, Jamie J. Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig E. Cameron, Steven C. Almo, 2018, Nature on p. 610-614
Functional characterization of the alphavirus TF protein
Jonathan E. Snyder, Kirsten A. Kulcsar, Kimberly L.W. Schultz, Catherine P. Riley, Jacob T. Neary, Scott Marr, Joyce Jose, Diane E. Griffin, Richard R. Kuhn, 2013, Journal of Virology on p. 8511-8523
Locking and blocking the viral landscape of an alphavirus with neutralizing antibodies
Jason Porta, Joyce Jose, John T. Roehrig, Carol D. Blair, Richard J. Kuhn, Michael G. Rossmann, 2014, Journal of Virology on p. 9616-9623
Structure-guided insights on the role of NS1 in flavivirus infection
David L. Akey, W. Clay Brown, Joyce Jose, Richard J. Kuhn, Janet L. Smith, 2015, BioEssays on p. 489-494
Spatial and temporal analysis of alphavirus replication and assembly in mammalian and mosquito cells
Joyce Jose, Aaron B. Taylor, Richard J. Kuhn, 2017, mBio
Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay
Anoop Narayanan, Manju Narwal, Sydney A. Majowicz, Carmine Varricchio, Shay A. Toner, Carlo Ballatore, Andrea Brancale, Katsuhiko S. Murakami, Joyce Jose, 2022, Communications Biology
Fluorescent protein-tagged sindbis virus E2 glycoprotein allows single particle analysis of virus budding from live cells
Joyce Jose, Jinghua Tang, Aaron B. Taylor, Timothy S. Baker, Richard J. Kuhn, 2015, Viruses on p. 6182-6199
Glycan-dependent chikungunya viral infection divulged by antiviral activity of NAG specific chi-like lectin
Ramanjit Kaur, Neetu, Rajat Mudgal, Joyce Jose, Pravindra Kumar, Shailly Tomar, 2019, Virology on p. 91-98
News Articles Featuring Joyce Jose
Feb 25, 2022
Repurposing FDA-approved drugs may help combat COVID-19
Several FDA-approved drugs — including for type 2 diabetes, hepatitis C and HIV — significantly reduce the ability of the Delta variant of SARS-CoV-2 to replicate in human cells, according to new research led by scientists at Penn State. Specifically, the team found that these drugs inhibit certain viral enzymes, called proteases, that are essential for SARS-CoV-2 replication in infected human cells.
Full Article
Sep 13, 2021
Eberly’s 2022 Lab Bench to Commercialization grant recipients announced
The Eberly College of Science has chosen faculty members Joyce Jose and Sally Mackenzie to receive its 2022 Lab Bench to Commercialization grants. This competitive program provides funding for researchers in the college, enabling them to enhance the commercial potential of ongoing Penn State research and prepare them to translate their Penn State-owned intellectual property to the marketplace.
Full Article
Jul 07, 2021
Fighting COVID with COVID
What if the COVID-19 virus could be used against itself? Researchers at Penn State have designed a proof-of-concept therapeutic that may be able to do just that. The team designed a synthetic defective SARS-CoV-2 virus that is innocuous but interferes with the real virus’ growth, potentially causing the extinction of both the disease-causing virus and the synthetic virus.
Full Article