Joyce Jose

Assistant Professor of Biochemistry & Molecular Biology

Joyce Jose

Research Summary

Virus-host interactions involved in the pathogenesis of alphaviruses and flaviviruses. Analysis of virus induced structures and cytoskeletal modifications in mammalian host and insect vector using high-resolution live cell imaging and electron microscopy. Viral determinants of neurotropism, encephalitis, transmission and persistence in BSL-3 pathogens.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Proteins Alphavirus Viruses Antiviral Agents Sindbis Virus Glycoproteins Heparitin Sulfate Human Genome Angiotensin Converting Enzyme 2 Ribonucleotides Heparin Lipids Flavivirus Immune System Membranes Nucleocapsid Cytidine Triphosphate Culicidae Infection Virus Release Virion Virus Diseases Neutralizing Antibodies Sindbis Virus Glycoprotein E2 Sars Virus

Most Recent Papers

Identification of a pocket factor that is critical to Zika virus assembly

Nadia M. DiNunno, Daniel J. Goetschius, Anoop Narayanan, Sydney A. Majowicz, Ibrahim Moustafa, Carol M. Bator, Susan L. Hafenstein, Joyce Jose, 2020, Nature Communications

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

Thomas Mandel Clausen, Daniel R. Sandoval, Charlotte B. Spliid, Jessica Pihl, Hailee R. Perrett, Chelsea D. Painter, Anoop Narayanan, Sydney A. Majowicz, Elizabeth M. Kwong, Rachael N. McVicar, Bryan E. Thacker, Charles A. Glass, Zhang Yang, Jonathan L. Torres, Gregory J. Golden, Phillip L. Bartels, Ryan N. Porell, Aaron F. Garretson, Logan Laubach, Jared Feldman, Xin Yin, Yuan Pu, Blake M. Hauser, Timothy M. Caradonna, Benjamin P. Kellman, Cameron Martino, Philip L.S.M. Gordts, Sumit K. Chanda, Aaron G. Schmidt, Kamil Godula, Sandra L. Leibel, Joyce Jose, Kevin D. Corbett, Andrew B. Ward, Aaron F. Carlin, Jeffrey D. Esko, 2020, Cell on p. 1043-1057.e15

Author Correction

Anthony S. Gizzi, Tyler L. Grove, Jamie J. Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig E. Cameron, Steven C. Almo, 2020, Nature on p. E15

Glycan-dependent chikungunya viral infection divulged by antiviral activity of NAG specific chi-like lectin

Ramanjit Kaur, Neetu, Rajat Mudgal, Joyce Jose, Pravindra Kumar, Shailly Tomar, 2019, Virology on p. 91-98

Erratum to

Anthony S. Gizzi, Tyler L. Grove, Jamie J. Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig E. Cameron, Steven C. Almo, 2018, Nature on p. E3

A naturally occurring antiviral ribonucleotide encoded by the human genome

Anthony S. Gizzi, Tyler L. Grove, Jamie Jon Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig Eugene Cameron, Steven C. Almo, 2018, Nature on p. 610-614

Spatial and temporal analysis of alphavirus replication and assembly in mammalian and mosquito cells

Joyce Jose, Aaron B. Taylor, Richard J. Kuhn, 2017, mBio

Fluorescent protein-tagged sindbis virus E2 glycoprotein allows single particle analysis of virus budding from live cells

Joyce Jose, Jinghua Tang, Aaron B. Taylor, Timothy S. Baker, Richard J. Kuhn, 2015, Viruses on p. 6182-6199

Structure-guided insights on the role of NS1 in flavivirus infection

David L. Akey, W. Clay Brown, Joyce Jose, Richard J. Kuhn, Janet L. Smith, 2015, BioEssays on p. 489-494

Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system

David L. Akey, W. Clay Brown, Somnath Dutta, Jamie Konwerski, Joyce Jose, Thomas J. Jurkiw, James DelProposto, Craig M. Ogata, Georgios Skiniotis, Richard J. Kuhn, Janet L. Smith, 2014, Science on p. 881-885

Most-Cited Papers

Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system

David L. Akey, W. Clay Brown, Somnath Dutta, Jamie Konwerski, Joyce Jose, Thomas J. Jurkiw, James DelProposto, Craig M. Ogata, Georgios Skiniotis, Richard J. Kuhn, Janet L. Smith, 2014, Science on p. 881-885

A naturally occurring antiviral ribonucleotide encoded by the human genome

Anthony S. Gizzi, Tyler L. Grove, Jamie Jon Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig Eugene Cameron, Steven C. Almo, 2018, Nature on p. 610-614

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

Thomas Mandel Clausen, Daniel R. Sandoval, Charlotte B. Spliid, Jessica Pihl, Hailee R. Perrett, Chelsea D. Painter, Anoop Narayanan, Sydney A. Majowicz, Elizabeth M. Kwong, Rachael N. McVicar, Bryan E. Thacker, Charles A. Glass, Zhang Yang, Jonathan L. Torres, Gregory J. Golden, Phillip L. Bartels, Ryan N. Porell, Aaron F. Garretson, Logan Laubach, Jared Feldman, Xin Yin, Yuan Pu, Blake M. Hauser, Timothy M. Caradonna, Benjamin P. Kellman, Cameron Martino, Philip L.S.M. Gordts, Sumit K. Chanda, Aaron G. Schmidt, Kamil Godula, Sandra L. Leibel, Joyce Jose, Kevin D. Corbett, Andrew B. Ward, Aaron F. Carlin, Jeffrey D. Esko, 2020, Cell on p. 1043-1057.e15

Functional characterization of the alphavirus TF protein

Jonathan E. Snyder, Kirsten A. Kulcsar, Kimberly L.W. Schultz, Catherine P. Riley, Jacob T. Neary, Scott Marr, Joyce Jose, Diane E. Griffin, Richard R. Kuhn, 2013, Journal of Virology on p. 8511-8523

Molecular links between the E2 envelope glycoprotein and nucleocapsid core in Sindbis virus

Jinghua Tang, Joyce Jose, Paul Chipman, Wei Zhang, Richard J. Kuhn, Timothy S. Baker, 2011, Journal of Molecular Biology on p. 442-459

Interactions of the cytoplasmic domain of sindbis virus E2 with nucleocapsid cores promote alphavirus budding

Joyce Jose, Laralynne Przybyla, Thomas J. Edwards, Rushika Perera, John W. Burgner, Richard J. Kuhn, 2012, Journal of Virology on p. 2585-2599

Locking and blocking the viral landscape of an alphavirus with neutralizing antibodies

Jason Porta, Joyce Jose, John T. Roehrig, Carol D. Blair, Richard J. Kuhn, Michael G. Rossmann, 2014, Journal of Virology on p. 9616-9623

Structure-guided insights on the role of NS1 in flavivirus infection

David L. Akey, W. Clay Brown, Joyce Jose, Richard J. Kuhn, Janet L. Smith, 2015, BioEssays on p. 489-494

Spatial and temporal analysis of alphavirus replication and assembly in mammalian and mosquito cells

Joyce Jose, Aaron B. Taylor, Richard J. Kuhn, 2017, mBio

Fluorescent protein-tagged sindbis virus E2 glycoprotein allows single particle analysis of virus budding from live cells

Joyce Jose, Jinghua Tang, Aaron B. Taylor, Timothy S. Baker, Richard J. Kuhn, 2015, Viruses on p. 6182-6199