Joyce Jose

Assistant Professor of Biochemistry & Molecular Biology

Joyce Jose

Research Summary

Virus-host interactions involved in the pathogenesis of alphaviruses and flaviviruses. Analysis of virus induced structures and cytoskeletal modifications in mammalian host and insect vector using high-resolution live cell imaging and electron microscopy. Viral determinants of neurotropism, encephalitis, transmission and persistence in BSL-3 pathogens.

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Publication Tags

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Viruses Proteins Antiviral Agents Alphavirus Sars Virus Glycoproteins Lipids Lycorine Drug Peptide Hydrolases Sindbis Virus Crystal Structure Membranes Cells Antiviral Drug Protease Inhibitor Daclatasvir Cytidine Triphosphate Heparitin Sulfate Ion Channels Active Sites Virus Release Assays Sitagliptin Heparin

Most Recent Publications

Anastazia Jablunovsky, Anoop Narayanan, Joyce Jose, 2024, PLoS Neglected Tropical Diseases

Sydney Majowicz, Anoop Narayanan, Ibrahim Moustafa, Carol Bator, Susan Hafenstein, Joyce Jose, 2023, npj Viruses

Zeinab Elmasri, Vashi Negi, Richard Kuhn, Joyce Jose, 2022, PLoS Pathogens on p. e1010892

Ankur Kumar, Deepak Kumar, Joyce Jose, Rajanish Giri, Indira Mysorekar, 2022, Frontiers in Virology

Joyce Jose, Susan L. Hafenstein, 2022, Current Opinion in Virology on p. 101230

Structure-based inhibitor design and repurposing clinical drugs to target SARS-CoV-2 proteases

Anoop Narayanan, Shay Toner, Joyce Jose, 2022, Biochemical Society Transactions on p. 151-165

Anoop Narayanan, Manju Narwal, Sydney Majowicz, Carmine Varricchio, Shay Toner, Carlo Ballotore, Carlo Ballatore, Andrea Brancale, Katsuhiko S. Murakami, Joyce Jose, 2022, Communications Biology on p. 169

Kellan T. Passow, Haley S. Caldwell, Kiet A. Ngo, Jamie J. Arnold, Jamie JArnold, Nicole M. Antczak, Anoop Narayanan, Joyce Jose, Shana J. Sturla, Craig E. Cameron, Alexander Ciota, D Harki, 2021, Journal of Medicinal Chemistry on p. 15429-15439

Zeinab Elmasri, Benjamin L. Nasal, Joyce Jose, 2021, Pathogens

Most-Cited Papers

Thomas Mandel Clausen, Daniel R. Sandoval, Charlotte B. Spliid, Jessica Pihl, Hailee R. Perrett, Chelsea D. Painter, Anoop Narayanan, Sydney A. Majowicz, Elizabeth M. Kwong, Rachael N. McVicar, Bryan E. Thacker, Charles A. Glass, Zhang Yang, Jonathan L. Torres, Gregory J. Golden, Phillip L. Bartels, Ryan N. Porell, Aaron F. Garretson, Logan Laubach, Jared Feldman, Xin Yin, Yuan Pu, Blake M. Hauser, Timothy M. Caradonna, Benjamin P. Kellman, Cameron Martino, Philip L.S.M. Gordts, Sumit K. Chanda, Aaron G. Schmidt, Kamil Godula, Sandra L. Leibel, Joyce Jose, Kevin D. Corbett, Andrew B. Ward, Aaron F. Carlin, Jeffrey D. Esko, 2020, Cell on p. 1043-1057.e15

David L. Akey, W. Clay Brown, Somnath Dutta, Jamie Konwerski, Joyce Jose, Thomas J. Jurkiw, James DelProposto, Craig M. Ogata, Georgios Skiniotis, Richard J. Kuhn, Janet L. Smith, 2014, Science on p. 881-885

Anthony S. Gizzi, Tyler L. Grove, Jamie J. Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig E. Cameron, Steven C. Almo, 2018, Nature on p. 610-614

Anoop Narayanan, Manju Narwal, Sydney Majowicz, Carmine Varricchio, Shay Toner, Carlo Ballotore, Carlo Ballatore, Andrea Brancale, Katsuhiko S. Murakami, Joyce Jose, 2022, Communications Biology on p. 169

David L. Akey, W. Clay Brown, Joyce Jose, Richard J. Kuhn, Janet L. Smith, 2015, BioEssays on p. 489-494

Jason Porta, Joyce Jose, John T. Roehrig, Carol D. Blair, Richard J. Kuhn, Michael G. Rossmann, 2014, Journal of Virology on p. 9616-9623

Ramanjit Kaur, Neetu, Rajat Mudgal, Joyce Jose, Pravindra Kumar, Shailly Tomar, 2019, Virology on p. 91-98

Nadia M. DiNunno, Daniel J. Goetschius, Anoop Narayanan, Sydney A. Majowicz, Ibrahim Moustafa, Carol M. Bator, Susan L. Hafenstein, Joyce Jose, 2020, Nature Communications

Joyce Jose, Jinghua Tang, Aaron B. Taylor, Timothy S. Baker, Richard J. Kuhn, 2015, Viruses on p. 6182-6199

News Articles Featuring Joyce Jose

How does Zika virus replicate and transmit from mother to fetus?

In 2015, an outbreak of Zika virus, driven by a heavy rain season and subsequent boom in the virus’s host mosquito population, caused thousands of babies in Brazil to be born with severe birth defects.

Repurposing FDA-approved drugs may help combat COVID-19

Several FDA-approved drugs — including for type 2 diabetes, hepatitis C and HIV — significantly reduce the ability of the Delta variant of SARS-CoV-2 to replicate in human cells, according to new research led by scientists at Penn State. Specifically, the team found that these drugs inhibit certain viral enzymes, called proteases, that are essential for SARS-CoV-2 replication in infected human cells.

Eberly’s 2022 Lab Bench to Commercialization grant recipients announced

The Eberly College of Science has chosen faculty members Joyce Jose and Sally Mackenzie to receive its 2022 Lab Bench to Commercialization grants. This competitive program provides funding for researchers in the college, enabling them to enhance the commercial potential of ongoing Penn State research and prepare them to translate their Penn State-owned intellectual property to the marketplace.

Fighting COVID with COVID

What if the COVID-19 virus could be used against itself? Researchers at Penn State have designed a proof-of-concept therapeutic that may be able to do just that. The team designed a synthetic defective SARS-CoV-2 virus that is innocuous but interferes with the real virus’ growth, potentially causing the extinction of both the disease-causing virus and the synthetic virus.