Joyce Jose
Assistant Professor of Biochemistry & Molecular Biology

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W206 Millennium Science Complex
University Park, - jxj321@psu.edu
- (814) 863-8806
Research Summary
Virus-host interactions involved in the pathogenesis of alphaviruses and flaviviruses. Analysis of virus induced structures and cytoskeletal modifications in mammalian host and insect vector using high-resolution live cell imaging and electron microscopy. Viral determinants of neurotropism, encephalitis, transmission and persistence in BSL-3 pathogens.
Huck Graduate Students
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- Center for Infectious Disease Dynamics
- Center for Structural Biology
Links
Publication Tags
Proteins Alphavirus Sindbis Virus Viruses Glycoproteins Heparin Heparitin Sulfate Angiotensin Converting Enzyme 2 Neutralizing Antibodies Nucleocapsid Virion Immune System Flavivirus Infection Antiviral Agents Membranes Virus Release Binding Sites Culicidae Genome Pathogenicity Capsid Proteins Virus Diseases Sindbis Virus Glycoprotein E2 Sars VirusMost Recent Papers
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
Thomas Mandel Clausen, Daniel R. Sandoval, Charlotte B. Spliid, Jessica Pihl, Hailee R. Perrett, Chelsea D. Painter, Anoop Narayanan, Sydney A. Majowicz, Elizabeth M. Kwong, Rachael N. McVicar, Bryan E. Thacker, Charles A. Glass, Zhang Yang, Jonathan L. Torres, Gregory J. Golden, Phillip L. Bartels, Ryan N. Porell, Aaron F. Garretson, Logan Laubach, Jared Feldman, Xin Yin, Yuan Pu, Blake M. Hauser, Timothy M. Caradonna, Benjamin P. Kellman, Cameron Martino, Philip L.S.M. Gordts, Sumit K. Chanda, Aaron G. Schmidt, Kamil Godula, Sandra L. Leibel, Joyce Jose, Kevin D. Corbett, Andrew B. Ward, Aaron F. Carlin, Jeffrey D. Esko, 2020, Cell on p. 1043-1057.e15
Glycan-dependent chikungunya viral infection divulged by antiviral activity of NAG specific chi-like lectin
Ramanjit Kaur, Neetu, Rajat Mudgal, Joyce Jose, Pravindra Kumar, Shailly Tomar, 2019, Virology on p. 91-98
A naturally occurring antiviral ribonucleotide encoded by the human genome
Anthony S. Gizzi, Tyler L. Grove, Jamie Jon Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig Eugene Cameron, Steven C. Almo, 2018, Nature on p. 610-614
Spatial and temporal analysis of alphavirus replication and assembly in mammalian and mosquito cells
Joyce Jose, Aaron B. Taylor, Richard J. Kuhn, 2017, mBio
Fluorescent protein-tagged sindbis virus E2 glycoprotein allows single particle analysis of virus budding from live cells
Joyce Jose, Jinghua Tang, Aaron B. Taylor, Timothy S. Baker, Richard J. Kuhn, 2015, Viruses on p. 6182-6199
Structure-guided insights on the role of NS1 in flavivirus infection
David L. Akey, W. Clay Brown, Joyce Jose, Richard J. Kuhn, Janet L. Smith, 2015, BioEssays on p. 489-494
Locking and blocking the viral landscape of an alphavirus with neutralizing antibodies
Jason Porta, Joyce Jose, John T. Roehrig, Carol D. Blair, Richard J. Kuhn, Michael G. Rossmann, 2014, Journal of Virology on p. 9616-9623
Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system
David L. Akey, W. Clay Brown, Somnath Dutta, Jamie Konwerski, Joyce Jose, Thomas J. Jurkiw, James DelProposto, Craig M. Ogata, Georgios Skiniotis, Richard J. Kuhn, Janet L. Smith, 2014, Science on p. 881-885
Functional characterization of the alphavirus TF protein
Jonathan E. Snyder, Kirsten A. Kulcsar, Kimberly L.W. Schultz, Catherine P. Riley, Jacob T. Neary, Scott Marr, Joyce Jose, Diane E. Griffin, Richard R. Kuhn, 2013, Journal of Virology on p. 8511-8523
Probing the early temporal and spatial interaction of the sindbis virus capsid and E2 proteins with reverse genetics
Jonathan E. Snyder, Christian J. Berrios, Thomas J. Edwards, Joyce Jose, Rushika Perera, Richard J. Kuhna, 2012, Journal of Virology on p. 12372-12383
Most-Cited Papers
Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system
David L. Akey, W. Clay Brown, Somnath Dutta, Jamie Konwerski, Joyce Jose, Thomas J. Jurkiw, James DelProposto, Craig M. Ogata, Georgios Skiniotis, Richard J. Kuhn, Janet L. Smith, 2014, Science on p. 881-885
A naturally occurring antiviral ribonucleotide encoded by the human genome
Anthony S. Gizzi, Tyler L. Grove, Jamie Jon Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig Eugene Cameron, Steven C. Almo, 2018, Nature on p. 610-614
Functional characterization of the alphavirus TF protein
Jonathan E. Snyder, Kirsten A. Kulcsar, Kimberly L.W. Schultz, Catherine P. Riley, Jacob T. Neary, Scott Marr, Joyce Jose, Diane E. Griffin, Richard R. Kuhn, 2013, Journal of Virology on p. 8511-8523
Molecular links between the E2 envelope glycoprotein and nucleocapsid core in Sindbis virus
Jinghua Tang, Joyce Jose, Paul Chipman, Wei Zhang, Richard J. Kuhn, Timothy S. Baker, 2011, Journal of Molecular Biology on p. 442-459
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
Thomas Mandel Clausen, Daniel R. Sandoval, Charlotte B. Spliid, Jessica Pihl, Hailee R. Perrett, Chelsea D. Painter, Anoop Narayanan, Sydney A. Majowicz, Elizabeth M. Kwong, Rachael N. McVicar, Bryan E. Thacker, Charles A. Glass, Zhang Yang, Jonathan L. Torres, Gregory J. Golden, Phillip L. Bartels, Ryan N. Porell, Aaron F. Garretson, Logan Laubach, Jared Feldman, Xin Yin, Yuan Pu, Blake M. Hauser, Timothy M. Caradonna, Benjamin P. Kellman, Cameron Martino, Philip L.S.M. Gordts, Sumit K. Chanda, Aaron G. Schmidt, Kamil Godula, Sandra L. Leibel, Joyce Jose, Kevin D. Corbett, Andrew B. Ward, Aaron F. Carlin, Jeffrey D. Esko, 2020, Cell on p. 1043-1057.e15
Interactions of the cytoplasmic domain of sindbis virus E2 with nucleocapsid cores promote alphavirus budding
Joyce Jose, Laralynne Przybyla, Thomas J. Edwards, Rushika Perera, John W. Burgner, Richard J. Kuhn, 2012, Journal of Virology on p. 2585-2599
Locking and blocking the viral landscape of an alphavirus with neutralizing antibodies
Jason Porta, Joyce Jose, John T. Roehrig, Carol D. Blair, Richard J. Kuhn, Michael G. Rossmann, 2014, Journal of Virology on p. 9616-9623
Structure-guided insights on the role of NS1 in flavivirus infection
David L. Akey, W. Clay Brown, Joyce Jose, Richard J. Kuhn, Janet L. Smith, 2015, BioEssays on p. 489-494
Spatial and temporal analysis of alphavirus replication and assembly in mammalian and mosquito cells
Joyce Jose, Aaron B. Taylor, Richard J. Kuhn, 2017, mBio
Fluorescent protein-tagged sindbis virus E2 glycoprotein allows single particle analysis of virus budding from live cells
Joyce Jose, Jinghua Tang, Aaron B. Taylor, Timothy S. Baker, Richard J. Kuhn, 2015, Viruses on p. 6182-6199