Joyce Jose
Assistant Professor of Biochemistry & Molecular Biology
-
W206 Millennium Science Complex
University Park, - jxj321@psu.edu
- (814) 863-8806
Research Summary
Virus-host interactions involved in the pathogenesis of alphaviruses and flaviviruses. Analysis of virus induced structures and cytoskeletal modifications in mammalian host and insect vector using high-resolution live cell imaging and electron microscopy. Viral determinants of neurotropism, encephalitis, transmission and persistence in BSL-3 pathogens.
Huck Graduate Students
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- Center for Infectious Disease Dynamics
- Center for Structural Biology
Links
Publication Tags
Proteins Alphavirus Viruses Antiviral Agents Sindbis Virus Glycoproteins Heparin Angiotensin Converting Enzyme 2 Ribonucleotides Human Genome Heparitin Sulfate Protein Lipids Cytidine Triphosphate Nucleocapsid Culicidae Infection Single Molecule Imaging Infections Virus Release Virion Flavivirus Immune System Membranes Virus DiseasesMost Recent Papers
A synthetic defective interfering SARS-CoV-2
Shun Yao, Anoop Narayanan, Sydney A. Majowicz, Joyce Jose, Marco Archetti, 2021, PeerJ
Identification of a pocket factor that is critical to Zika virus assembly
Nadia M. DiNunno, Daniel J. Goetschius, Anoop Narayanan, Sydney A. Majowicz, Ibrahim Moustafa, Carol M. Bator, Susan L. Hafenstein, Joyce Jose, 2020, Nature Communications
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
Thomas Mandel Clausen, Daniel R. Sandoval, Charlotte B. Spliid, Jessica Pihl, Hailee R. Perrett, Chelsea D. Painter, Anoop Narayanan, Sydney A. Majowicz, Elizabeth M. Kwong, Rachael N. McVicar, Bryan E. Thacker, Charles A. Glass, Zhang Yang, Jonathan L. Torres, Gregory J. Golden, Phillip L. Bartels, Ryan N. Porell, Aaron F. Garretson, Logan Laubach, Jared Feldman, Xin Yin, Yuan Pu, Blake M. Hauser, Timothy M. Caradonna, Benjamin P. Kellman, Cameron Martino, Philip L.S.M. Gordts, Sumit K. Chanda, Aaron G. Schmidt, Kamil Godula, Sandra L. Leibel, Joyce Jose, Kevin D. Corbett, Andrew B. Ward, Aaron F. Carlin, Jeffrey D. Esko, 2020, Cell on p. 1043-1057.e15
Author Correction
Anthony S. Gizzi, Tyler L. Grove, Jamie J. Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig E. Cameron, Steven C. Almo, 2020, Nature on p. E15
Glycan-dependent chikungunya viral infection divulged by antiviral activity of NAG specific chi-like lectin
Ramanjit Kaur, Neetu, Rajat Mudgal, Joyce Jose, Pravindra Kumar, Shailly Tomar, 2019, Virology on p. 91-98
Erratum to
Anthony S. Gizzi, Tyler L. Grove, Jamie J. Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig E. Cameron, Steven C. Almo, 2018, Nature on p. E3
A naturally occurring antiviral ribonucleotide encoded by the human genome
Anthony S. Gizzi, Tyler L. Grove, Jamie J. Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig E. Cameron, Steven C. Almo, 2018, Nature on p. 610-614
Spatial and temporal analysis of alphavirus replication and assembly in mammalian and mosquito cells
Joyce Jose, Aaron B. Taylor, Richard J. Kuhn, 2017, mBio
Fluorescent protein-tagged sindbis virus E2 glycoprotein allows single particle analysis of virus budding from live cells
Joyce Jose, Jinghua Tang, Aaron B. Taylor, Timothy S. Baker, Richard J. Kuhn, 2015, Viruses on p. 6182-6199
Structure-guided insights on the role of NS1 in flavivirus infection
David L. Akey, W. Clay Brown, Joyce Jose, Richard J. Kuhn, Janet L. Smith, 2015, BioEssays on p. 489-494
Most-Cited Papers
Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system
David L. Akey, W. Clay Brown, Somnath Dutta, Jamie Konwerski, Joyce Jose, Thomas J. Jurkiw, James DelProposto, Craig M. Ogata, Georgios Skiniotis, Richard J. Kuhn, Janet L. Smith, 2014, Science on p. 881-885
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
Thomas Mandel Clausen, Daniel R. Sandoval, Charlotte B. Spliid, Jessica Pihl, Hailee R. Perrett, Chelsea D. Painter, Anoop Narayanan, Sydney A. Majowicz, Elizabeth M. Kwong, Rachael N. McVicar, Bryan E. Thacker, Charles A. Glass, Zhang Yang, Jonathan L. Torres, Gregory J. Golden, Phillip L. Bartels, Ryan N. Porell, Aaron F. Garretson, Logan Laubach, Jared Feldman, Xin Yin, Yuan Pu, Blake M. Hauser, Timothy M. Caradonna, Benjamin P. Kellman, Cameron Martino, Philip L.S.M. Gordts, Sumit K. Chanda, Aaron G. Schmidt, Kamil Godula, Sandra L. Leibel, Joyce Jose, Kevin D. Corbett, Andrew B. Ward, Aaron F. Carlin, Jeffrey D. Esko, 2020, Cell on p. 1043-1057.e15
A naturally occurring antiviral ribonucleotide encoded by the human genome
Anthony S. Gizzi, Tyler L. Grove, Jamie J. Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig E. Cameron, Steven C. Almo, 2018, Nature on p. 610-614
Functional characterization of the alphavirus TF protein
Jonathan E. Snyder, Kirsten A. Kulcsar, Kimberly L.W. Schultz, Catherine P. Riley, Jacob T. Neary, Scott Marr, Joyce Jose, Diane E. Griffin, Richard R. Kuhn, 2013, Journal of Virology on p. 8511-8523
Molecular links between the E2 envelope glycoprotein and nucleocapsid core in Sindbis virus
Jinghua Tang, Joyce Jose, Paul Chipman, Wei Zhang, Richard J. Kuhn, Timothy S. Baker, 2011, Journal of Molecular Biology on p. 442-459
Locking and blocking the viral landscape of an alphavirus with neutralizing antibodies
Jason Porta, Joyce Jose, John T. Roehrig, Carol D. Blair, Richard J. Kuhn, Michael G. Rossmann, 2014, Journal of Virology on p. 9616-9623
Interactions of the cytoplasmic domain of sindbis virus E2 with nucleocapsid cores promote alphavirus budding
Joyce Jose, Laralynne Przybyla, Thomas J. Edwards, Rushika Perera, John W. Burgner, Richard J. Kuhn, 2012, Journal of Virology on p. 2585-2599
Structure-guided insights on the role of NS1 in flavivirus infection
David L. Akey, W. Clay Brown, Joyce Jose, Richard J. Kuhn, Janet L. Smith, 2015, BioEssays on p. 489-494
Spatial and temporal analysis of alphavirus replication and assembly in mammalian and mosquito cells
Joyce Jose, Aaron B. Taylor, Richard J. Kuhn, 2017, mBio
Fluorescent protein-tagged sindbis virus E2 glycoprotein allows single particle analysis of virus budding from live cells
Joyce Jose, Jinghua Tang, Aaron B. Taylor, Timothy S. Baker, Richard J. Kuhn, 2015, Viruses on p. 6182-6199
News Articles Featuring Joyce Jose
Sep 13, 2021
Eberly’s 2022 Lab Bench to Commercialization grant recipients announced
The Eberly College of Science has chosen faculty members Joyce Jose and Sally Mackenzie to receive its 2022 Lab Bench to Commercialization grants. This competitive program provides funding for researchers in the college, enabling them to enhance the commercial potential of ongoing Penn State research and prepare them to translate their Penn State-owned intellectual property to the marketplace.
Full Article
Jul 07, 2021
Fighting COVID with COVID
What if the COVID-19 virus could be used against itself? Researchers at Penn State have designed a proof-of-concept therapeutic that may be able to do just that. The team designed a synthetic defective SARS-CoV-2 virus that is innocuous but interferes with the real virus’ growth, potentially causing the extinction of both the disease-causing virus and the synthetic virus.
Full Article