Jean-Paul Armache

Assistant Professor of of Biochemistry and Molecular Biology

Jean-Paul Armache

Research Summary

The mechanisms and functions of ATP-dependent chromatin remodeling complexes and their place in gene regulation.

Huck Affiliations

Links

Publication Tags

Proteins Nucleosomes Histones Protein Subunits Ubiquitination Dna Cryoelectron Microscopy Lysine Ribosomes Enzymes Heme Membrane Proteins Nanoparticles Signal Transduction Protein Saposins Histone Lipoproteins Adenosine Diphosphate Methylation Leukemia Membranes Ubiquitin Single Molecule Imaging Ion Channels

Most Recent Publications

Lake microbiome and trophy fluctuations of the ancient hemp rettery

Olga Iwańska, Przemysław Latoch, Magdalena Suchora, Irena A. Pidek, Miłosz Huber, Iwona Bubak, Natalia Kopik, Mariia Kovalenko, Michał Gąsiorowski, Jean Paul Armache, Agata L. Starosta, 2022, Scientific Reports

Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state

Ilana M. Nodelman, Sayan Das, Anneliese M. Faustino, Stephen D. Fried, Gregory D. Bowman, Jean Paul Armache, 2022, Nature Structural Biology on p. 121-129

Heme-Edge Residues Modulate Signal Transduction within a Bifunctional Homo-Dimeric Sensor Protein

Dayna Patterson, Yilin Liu, Sayan Das, Neela H. Yennawar, Jean-Paul Armache, James Kincaid, Emily E. Weinert, 2021, Biochemistry on p. 3801-3812

Differential ligand-selective control of opposing enzymatic activities within a bifunctional c-di-GMP enzyme

Dayna Patterson, Myrrh Perez Ruiz, Myrrh Perez Ruiz, Hyerin Yoon, Johnnie Walker, Jean-Paul Armache, Neela Yennawar, Emily Weinert, 2021, Proceedings of the National Academy of Sciences of the United States of America on p. 9

Sharing biological data: why, when, and how

Samantha L. Wilson, Gregory P. Way, Wout Bittremieux, Jean Paul Armache, Melissa A. Haendel, Michael M. Hoffman, 2021, FEBS Letters on p. 847-863

Regulation of the Dot1 histone H3K79 methyltransferase by histone H4K16 acetylation

Marco Igor Valencia-Sánchez, Pablo De Ioannes, Miao Wang, David M. Truong, Rachel Lee, Jean Paul Armache, Jef D. Boeke, Karim Jean Armache, 2021, Science

Cryo-EM of multiple cage architectures reveals a universal mode of clathrin self-assembly

Kyle L. Morris, Joseph R. Jones, Mary Halebian, Shenping Wu, Michael Baker, Jean Paul Armache, Amaurys Avila Ibarra, Richard B. Sessions, Alexander D. Cameron, Yifan Cheng, Corinne J. Smith, 2019, Nature Structural Biology on p. 890-898

Single-particle cryo-EM: Beyond the resolution

Jean Paul Armache, Yifan Cheng, 2019, National Science Review on p. 864-866

Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination

Marco Igor Valencia-Sánchez, Pablo De Ioannes, Miao Wang, Nikita Vasilyev, Ruoyu Chen, Evgeny Nudler, Jean Paul Armache, Karim Jean Armache, 2019, Molecular Cell on p. 1010-1019.e6

Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome

Jean Paul Armache, Nathan Gamarra, Stephanie L. Johnson, John D. Leonard, Shenping Wu, Geeta J. Narlikar, Yifan Cheng, 2019, eLife

Most-Cited Papers

MotionCor2: Anisotropic correction of beam-induced motion for improved cryo-electron microscopy

Shawn Q. Zheng, Eugene Palovcak, Jean Paul Armache, Kliment A. Verba, Yifan Cheng, David A. Agard, 2017, Nature Methods on p. 331-332

Structure of the TRPA1 ion channel suggests regulatory mechanisms

Candice E. Paulsen, Jean Paul Armache, Yuan Gao, Yifan Cheng, David Julius, 2015, Nature on p. 511-517

Structures of the human and Drosophila 80S ribosome

Andreas M. Anger, Jean Paul Armache, Otto Berninghausen, Michael Habeck, Marion Subklewe, Daniel N. Wilson, Roland Beckmann, 2013, Nature on p. 80-85

A saposin-lipoprotein nanoparticle system for membrane proteins

Jens Frauenfeld, Robin Löving, Jean Paul Armache, Andreas F.P. Sonnen, Fatma Guettou, Per Moberg, Lin Zhu, Caroline Jegerschöld, Ali Flayhan, John A.G. Briggs, Henrik Garoff, Christian Löw, Yifan Cheng, Pär Nordlund, 2016, Nature Methods on p. 345-351

Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion

Marko Gogala, Thomas Becker, Birgitta Beatrix, Jean Paul Armache, Clara Barrio-Garcia, Otto Berninghausen, Roland Beckmann, 2014, Nature on p. 107-110

Cryo-EM structure of a fungal mitochondrial calcium uniporter

Nam X. Nguyen, Jean Paul Armache, Changkeun Lee, Yi Yang, Weizhong Zeng, Vamsi K. Mootha, Yifan Cheng, Xiao chen Bai, Youxing Jiang, 2018, Nature on p. 570-574

Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination

Marco Igor Valencia-Sánchez, Pablo De Ioannes, Miao Wang, Nikita Vasilyev, Ruoyu Chen, Evgeny Nudler, Jean Paul Armache, Karim Jean Armache, 2019, Molecular Cell on p. 1010-1019.e6

Erratum: Structure of the TRPA1 ion channel suggests regulatory mechanisms (Nature (2015) 520 (511-517) DOI:10.1038/nature14367)

Candice E. Paulsen, Jean Paul Armache, Yuan Gao, Yifan Cheng, David Julius, 2015, Nature on p. 552

Promiscuous behaviour of archaeal ribosomal proteins: Implications for eukaryotic ribosome evolution

Jean Paul Armache, Andreas M. Anger, Viter Márquez, Sibylle Franckenberg, Thomas Fröhlich, Elizabeth Villa, Otto Berninghausen, Michael Thomm, Georg J. Arnold, Roland Beckmann, Daniel N. Wilson, 2013, Nucleic Acids Research on p. 1284-1293

Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome

Jean Paul Armache, Nathan Gamarra, Stephanie L. Johnson, John D. Leonard, Shenping Wu, Geeta J. Narlikar, Yifan Cheng, 2019, eLife