Jean-Paul Armache

Assistant Professor of of Biochemistry and Molecular Biology

Jean-Paul Armache

Research Summary

The mechanisms and functions of ATP-dependent chromatin remodeling complexes and their place in gene regulation.

Huck Affiliations

Links

Most Recent Publications

Multiplicity of Regulatory Subunit Conformations Defines Structural Ensemble of Reset Protein Kinase A Holoenzyme

Varun Venkatakrishnan, Tatiana N. Laremore, Theresa S.C. Buckley, Jean Paul Armache, Ganesh S. Anand, 2025, Journal of the American Chemical Society on p. 14174-14190

Read–write mechanisms of H2A ubiquitination by Polycomb repressive complex 1

Victoria Godínez López, Marco Igor Valencia-Sánchez, Stephen Abini-Agbomson, Jonathan F. Thomas, Rachel Lee, Pablo De Ioannes, Brian A. Sosa, Jean Paul Armache, Karim Jean Armache, 2024, Nature on p. 755-761

Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking

Un Seng Chio, Eugene Palovcak, Anton A.A. Smith, Henriette Autzen, Elise N. Muñoz, Zanlin Yu, Feng Wang, David A. Agard, Jean Paul Armache, Geeta J. Narlikar, Yifan Cheng, 2024, Nature Communications

Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1

Stephen Abini-Agbomson, Kristjan Gretarsson, Rochelle M. Shih, Laura Hsieh, Tracy Lou, Pablo De Ioannes, Nikita Vasilyev, Rachel Lee, Miao Wang, Matthew D. Simon, Jean Paul Armache, Evgeny Nudler, Geeta Narlikar, Shixin Liu, Chao Lu, Karim Jean Armache, 2023, Molecular Cell on p. 2872-2883.e7

SARS-CoV-2 polyprotein substrate regulates the stepwise M<sup>pro</sup> cleavage reaction

Manju Narwal, Jean Paul Armache, Thomas J. Edwards, Katsuhiko S. Murakami, 2023, Journal of Biological Chemistry

Ribosome heterogeneity and specialization of Plasmodium parasites

James P. McGee, Jean Paul Armache, Scott E. Lindner, 2023, PLoS Pathogens

Cryo-EM structure of the human Sirtuin 6–nucleosome complex

Un Seng Chio, Othman Rechiche, Alysia R. Bryll, Jiang Zhu, Erik M. Leith, Jessica L. Feldman, Craig L. Peterson, Song Tan, Jean Paul Armache, 2023, Science advances

Lake microbiome and trophy fluctuations of the ancient hemp rettery

Olga Iwańska, Przemysław Latoch, Magdalena Suchora, Irena A. Pidek, Miłosz Huber, Iwona Bubak, Natalia Kopik, Mariia Kovalenko, Michał Gąsiorowski, Jean Paul Armache, Agata L. Starosta, 2022, Scientific Reports

Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state

Ilana M. Nodelman, Sayan Das, Anneliese M. Faustino, Stephen D. Fried, Gregory D. Bowman, Jean Paul Armache, 2022, Nature Structural Biology on p. 121-129

Heme-Edge Residues Modulate Signal Transduction within a Bifunctional Homo-Dimeric Sensor Protein

Dayna Patterson, Yilin Liu, Sayan Das, Neela Yennawar, Jean-Paul Armache, James Kincaid, Emily E. Weinert, 2021, Biochemistry on p. 3801-3812

Most-Cited Papers

MotionCor2: Anisotropic correction of beam-induced motion for improved cryo-electron microscopy

Shawn Q. Zheng, Eugene Palovcak, Jean Paul Armache, Kliment A. Verba, Yifan Cheng, David A. Agard, 2017, Nature Methods on p. 331-332

Structure of the TRPA1 ion channel suggests regulatory mechanisms

Candice E. Paulsen, Jean Paul Armache, Yuan Gao, Yifan Cheng, David Julius, 2015, Nature on p. 511-517

A saposin-lipoprotein nanoparticle system for membrane proteins

Jens Frauenfeld, Robin Löving, Jean Paul Armache, Andreas F.P. Sonnen, Fatma Guettou, Per Moberg, Lin Zhu, Caroline Jegerschöld, Ali Flayhan, John A.G. Briggs, Henrik Garoff, Christian Löw, Yifan Cheng, Pär Nordlund, 2016, Nature Methods on p. 345-351

Cryo-EM structure of a fungal mitochondrial calcium uniporter

Nam X. Nguyen, Jean Paul Armache, Changkeun Lee, Yi Yang, Weizhong Zeng, Vamsi K. Mootha, Yifan Cheng, Xiao chen Bai, Youxing Jiang, 2018, Nature on p. 570-574

Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination

Marco Igor Valencia-Sánchez, Pablo De Ioannes, Miao Wang, Nikita Vasilyev, Ruoyu Chen, Evgeny Nudler, Jean Paul Armache, Karim Jean Armache, 2019, Molecular Cell on p. 1010-1019.e6

Regulation of the Dot1 histone H3K79 methyltransferase by histone H4K16 acetylation

Marco Igor Valencia-Sánchez, Pablo De Ioannes, Miao Wang, David M. Truong, Rachel Lee, Jean Paul Armache, Jef D. Boeke, Karim Jean Armache, 2021, Science

Erratum: Structure of the TRPA1 ion channel suggests regulatory mechanisms (Nature (2015) 520 (511-517) DOI:10.1038/nature14367)

Candice E. Paulsen, Jean Paul Armache, Yuan Gao, Yifan Cheng, David Julius, 2015, Nature on p. 552

Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome

Jean Paul Armache, Nathan Gamarra, Stephanie L. Johnson, John D. Leonard, Shenping Wu, Geeta J. Narlikar, Yifan Cheng, 2019, eLife

Cryo-EM of multiple cage architectures reveals a universal mode of clathrin self-assembly

Kyle L. Morris, Joseph R. Jones, Mary Halebian, Shenping Wu, Michael Baker, Jean Paul Armache, Amaurys Avila Ibarra, Richard B. Sessions, Alexander D. Cameron, Yifan Cheng, Corinne J. Smith, 2019, Nature Structural Biology on p. 890-898

Single-particle cryo-EM data acquisition by using direct electron detection camera

Shenping Wu, Jean Paul Armache, Yifan Cheng, 2016, Microscopy (Oxford, England) on p. 35-41

News Articles Featuring Jean-Paul Armache

Sep 11, 2024

Three projects receive Huck Innovative and Transformational Seed Fund grants

Three potentially high-impact, high-risk research projects have been selected to receive seed funding for the latest round of the Huck Innovative and Transformational Seed (HITS) Fund initiative.

Full Article

May 30, 2023

Essential process for SARS-CoV-2 viral replication visualized

During the replication of the SARS-CoV-2 virus, a long string of connected proteins is cleaved apart into individual proteins.

Full Article

Apr 14, 2023

How does an aging-associated enzyme access our genetic material?

New research provides insight into how an enzyme that helps regulate aging and other metabolic processes accesses our genetic material to modulate gene expression within the cell. A team led by Penn State researchers have produced images of a sirtuin enzyme bound to a nucleosome — a tightly packed complex of DNA and proteins called histones — showing how the enzyme navigates the nucleosome complex to access both DNA and histone proteins and clarifying how it functions in humans and other animals.

Full Article

Aug 11, 2020

Determining how a coronavirus protein takes over human protein-making machinery

Jean-Paul Armache, assistant professor of biochemistry and molecular biology, has been awarded seed funding from the Huck Institutes of the Life Sciences at Penn State to use cryo-electron microscopy to study how an important SARS-CoV-2 protein binds to and takes over the human ribosome — a protein factory in the cell that the virus uses to copy itself.

Full Article