Jean-Paul Armache
Assistant Professor of of Biochemistry and Molecular Biology
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428 South Frear
University Park, PA - jza449@psu.edu
- 814-863-0152
Research Summary
The mechanisms and functions of ATP-dependent chromatin remodeling complexes and their place in gene regulation.
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- Center for Structural Biology
- Center for Infectious Disease Dynamics
Links
Publication Tags
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Proteins Nucleosomes Histones Protein Heme Cryoelectron Microscopy Dna Enzymes Membrane Proteins Protein Subunits Nanoparticles Saposins Lipoproteins Signal Transduction Ubiquitination Lysine Membranes Single Molecule Imaging Peptides Ion Channels Electron Microscopy Ligands Cyclic Gmp Analgesics CannabisMost Recent Publications
Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking
Un Seng Chio, Eugene Palovcak, Anton A.A. Smith, Henriette Autzen, Elise N. Muñoz, Zanlin Yu, Feng Wang, David A. Agard, Jean Paul Armache, Geeta J. Narlikar, Yifan Cheng, 2024, Nature Communications
Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1
Stephen Abini-Agbomson, Kristjan Gretarsson, Rochelle M. Shih, Laura Hsieh, Tracy Lou, Pablo De Ioannes, Nikita Vasilyev, Rachel Lee, Miao Wang, Matthew D. Simon, Jean Paul Armache, Evgeny Nudler, Geeta Narlikar, Shixin Liu, Chao Lu, Karim Jean Armache, 2023, Molecular Cell on p. 2872-2883.e7
SARS-CoV-2 polyprotein substrate regulates the stepwise M<sup>pro</sup> cleavage reaction
Manju Narwal, Jean Paul Armache, Thomas J. Edwards, Katsuhiko S. Murakami, 2023, Journal of Biological Chemistry
Ribosome heterogeneity and specialization of Plasmodium parasites
James P. McGee, Jean Paul Armache, Scott E. Lindner, 2023, PLoS Pathogens
Cryo-EM structure of the human Sirtuin 6–nucleosome complex
Un Seng Chio, Othman Rechiche, Alysia R. Bryll, Jiang Zhu, Erik M. Leith, Jessica L. Feldman, Craig L. Peterson, Song Tan, Jean Paul Armache, 2023, Science advances
Lake microbiome and trophy fluctuations of the ancient hemp rettery
Olga Iwańska, Przemysław Latoch, Magdalena Suchora, Irena A. Pidek, Miłosz Huber, Iwona Bubak, Natalia Kopik, Mariia Kovalenko, Michał Gąsiorowski, Jean Paul Armache, Agata L. Starosta, 2022, Scientific Reports
Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state
Ilana M. Nodelman, Sayan Das, Anneliese M. Faustino, Stephen D. Fried, Gregory D. Bowman, Jean Paul Armache, 2022, Nature Structural Biology on p. 121-129
Heme-Edge Residues Modulate Signal Transduction within a Bifunctional Homo-Dimeric Sensor Protein
Dayna Patterson, Yilin Liu, Sayan Das, Neela H. Yennawar, Jean-Paul Armache, James Kincaid, Emily E. Weinert, 2021, Biochemistry on p. 3801-3812
Differential ligand-selective control of opposing enzymatic activities within a bifunctional c-di-GMP enzyme
Dayna Patterson, Myrrh Perez Ruiz, Myrrh Perez Ruiz, Hyerin Yoon, Johnnie Walker, Jean-Paul Armache, Neela Yennawar, Emily Weinert, 2021, Proceedings of the National Academy of Sciences of the United States of America on p. 9
Sharing biological data: why, when, and how
Samantha L. Wilson, Gregory P. Way, Wout Bittremieux, Jean Paul Armache, Melissa A. Haendel, Michael M. Hoffman, 2021, FEBS Letters on p. 847-863
Most-Cited Papers
MotionCor2: Anisotropic correction of beam-induced motion for improved cryo-electron microscopy
Shawn Q. Zheng, Eugene Palovcak, Jean Paul Armache, Kliment A. Verba, Yifan Cheng, David A. Agard, 2017, Nature Methods on p. 331-332
Structure of the TRPA1 ion channel suggests regulatory mechanisms
Candice E. Paulsen, Jean Paul Armache, Yuan Gao, Yifan Cheng, David Julius, 2015, Nature on p. 511-517
A saposin-lipoprotein nanoparticle system for membrane proteins
Jens Frauenfeld, Robin Löving, Jean Paul Armache, Andreas F.P. Sonnen, Fatma Guettou, Per Moberg, Lin Zhu, Caroline Jegerschöld, Ali Flayhan, John A.G. Briggs, Henrik Garoff, Christian Löw, Yifan Cheng, Pär Nordlund, 2016, Nature Methods on p. 345-351
Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion
Marko Gogala, Thomas Becker, Birgitta Beatrix, Jean Paul Armache, Clara Barrio-Garcia, Otto Berninghausen, Roland Beckmann, 2014, Nature on p. 107-110
Cryo-EM structure of a fungal mitochondrial calcium uniporter
Nam X. Nguyen, Jean Paul Armache, Changkeun Lee, Yi Yang, Weizhong Zeng, Vamsi K. Mootha, Yifan Cheng, Xiao chen Bai, Youxing Jiang, 2018, Nature on p. 570-574
Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination
Marco Igor Valencia-Sánchez, Pablo De Ioannes, Miao Wang, Nikita Vasilyev, Ruoyu Chen, Evgeny Nudler, Jean Paul Armache, Karim Jean Armache, 2019, Molecular Cell on p. 1010-1019.e6
Erratum: Structure of the TRPA1 ion channel suggests regulatory mechanisms (Nature (2015) 520 (511-517) DOI:10.1038/nature14367)
Candice E. Paulsen, Jean Paul Armache, Yuan Gao, Yifan Cheng, David Julius, 2015, Nature on p. 552
Regulation of the Dot1 histone H3K79 methyltransferase by histone H4K16 acetylation
Marco Igor Valencia-Sánchez, Pablo De Ioannes, Miao Wang, David M. Truong, Rachel Lee, Jean Paul Armache, Jef D. Boeke, Karim Jean Armache, 2021, Science
Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome
Jean Paul Armache, Nathan Gamarra, Stephanie L. Johnson, John D. Leonard, Shenping Wu, Geeta J. Narlikar, Yifan Cheng, 2019, eLife
Cryo-EM of multiple cage architectures reveals a universal mode of clathrin self-assembly
Kyle L. Morris, Joseph R. Jones, Mary Halebian, Shenping Wu, Michael Baker, Jean Paul Armache, Amaurys Avila Ibarra, Richard B. Sessions, Alexander D. Cameron, Yifan Cheng, Corinne J. Smith, 2019, Nature Structural Biology on p. 890-898
News Articles Featuring Jean-Paul Armache
May 30, 2023
Essential process for SARS-CoV-2 viral replication visualized
During the replication of the SARS-CoV-2 virus, a long string of connected proteins is cleaved apart into individual proteins.
Full Article
Apr 14, 2023
How does an aging-associated enzyme access our genetic material?
New research provides insight into how an enzyme that helps regulate aging and other metabolic processes accesses our genetic material to modulate gene expression within the cell. A team led by Penn State researchers have produced images of a sirtuin enzyme bound to a nucleosome — a tightly packed complex of DNA and proteins called histones — showing how the enzyme navigates the nucleosome complex to access both DNA and histone proteins and clarifying how it functions in humans and other animals.
Full Article
Aug 11, 2020
Determining how a coronavirus protein takes over human protein-making machinery
Jean-Paul Armache, assistant professor of biochemistry and molecular biology, has been awarded seed funding from the Huck Institutes of the Life Sciences at Penn State to use cryo-electron microscopy to study how an important SARS-CoV-2 protein binds to and takes over the human ribosome — a protein factory in the cell that the virus uses to copy itself.
Full Article