Scott Showalter

Professor of Chemistry; Professor of Biochemistry and Molecular Biology

Scott Showalter

Research Summary

Biophysical Chemistry applied to solution NMR spectroscopy of partially disordered proteins. NMR studies of protein dynamics coupled with computational and theoretical studies of the coupling between nuclear spin relaxation and molecular motion.

Huck Affiliations

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Publication Tags

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Proteins Protein Intrinsically Disordered Proteins Phosphorylation Rna Nmr Spectroscopy Magnetic Resonance Spectroscopy Nuclear Magnetic Resonance Rna Polymerase Ii Application Lysine Carbon Micrornas Nuclear Magnetic Resonance Spectroscopy Statistical Ensemble Proline Modification Proteome Rna Polymerase Iii Viral Proteins Switches Double Stranded Rna Anti Bacterial Agents Cyclic Amp Dependent Protein Kinases Acetylation

Most Recent Publications

Advances in direct detection of lysine methylation and acetylation by nuclear magnetic resonance using <sup>13</sup>C-enriched cofactors

Olivia A. Fraser, Kevin E.W. Namitz, Scott A. Showalter, 2023, ImmunoMethods on p. 72-83

Structural characterization of the RNA polymerase II CTD in different phosphorylation states

Wei Chen, Oluwadamilare Aboyewa, Scott A. Showalter, 2023, Biophysical Journal on p. 202a

A direct nuclear magnetic resonance method to investigate lysine acetylation of intrinsically disordered proteins

Olivia A. Fraser, Sophia M. Dewing, Emery T. Usher, Christy George, Scott A. Showalter, 2023, Frontiers in Molecular Biosciences

Biophysical insights into glucose-dependent transcriptional regulation by PDX1

Emery T. Usher, Scott A. Showalter, 2022, Journal of Biological Chemistry

Probing multiple enzymatic methylation events in real time with NMR spectroscopy

Emery T. Usher, Kevin E.W. Namitz, Michael S. Cosgrove, Scott A. Showalter, 2021, Biophysical Journal on p. 4710-4721

Transient Electrostatic Interactions between Fcp1 and Rap74 Bias the Conformational Ensemble of the Complex with Minimal Impact on Binding Affinity

Victor A. Prieto, Kevin E.W. Namitz, Scott A. Showalter, 2021, Journal of Physical Chemistry B on p. 10917-10927

Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity

Emery T. Usher, Nafiseh Sabri, Roman Rohac, Amie K. Boal, Tanja Mittag, Scott A. Showalter, 2021, Journal of Biological Chemistry

Mapping invisible epitopes by NMR spectroscopy

Emery T. Usher, Scott A. Showalter, 2020, Journal of Biological Chemistry on p. 17411-17412

Elucidating the Role of Microprocessor Protein DGCR8 in Bending RNA Structures

Suzette A. Pabit, Yen Lin Chen, Emery T. Usher, Erik C. Cook, Lois Pollack, Scott A. Showalter, 2020, Biophysical Journal on p. 2524-2536

An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen

Valerie J. Morley, Clare Kinnear, Derek G. Sim, Samantha N. Olson, Samantha Olsen, Lindsey Jackson, Elsa Hansen, Grace Usher, Scott A. Showalter, Manjunath Pai, Robert Woods, Andrew F. Read, 2020, eLife on p. 1-17

Most-Cited Papers

Application of NMR to studies of intrinsically disordered proteins

Eric B. Gibbs, Erik C. Cook, Scott A. Showalter, 2017, Archives of Biochemistry and Biophysics on p. 57-70

Structural Basis for Rare Earth Element Recognition by Methylobacterium extorquens Lanmodulin

Erik C. Cook, Emily R. Featherston, Scott A. Showalter, Joseph A. Cotruvo, 2019, Biochemistry on p. 120-125

Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain

Eric B. Gibbs, Feiyue Lu, Bede Portz, Michael J. Fisher, Brenda P. Medellin, Tatiana N. Laremore, Yan Jessie Zhang, David S. Gilmour, Scott A. Showalter, 2017, Nature Communications

Quantitative biophysical characterization of intrinsically disordered proteins

Eric B. Gibbs, Scott A. Showalter, 2015, Biochemistry on p. 1314-1326

Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain

Bede Portz, Feiyue Lu, Eric B. Gibbs, Joshua E. Mayfield, M. Rachel Mehaffey, Yan Jessie Zhang, Jennifer S. Brodbelt, Scott A. Showalter, David S. Gilmour, 2017, Nature Communications

Generating NMR chemical shift assignments of intrinsically disordered proteins using carbon-detected NMR methods

Debashish Sahu, Monique Bastidas, Scott A. Showalter, 2014, Analytical Biochemistry on p. 17-25

A primer for carbon-detected NMR applications to intrinsically disordered proteins in solution

Monique Bastidas, Eric B. Gibbs, Debashish Sahu, Scott A. Showalter, 2015, Concepts in Magnetic Resonance Part A: Bridging Education and Research on p. 54-66

Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks

Janna Sloand, Janna Sloand^, Eric Cook, Theodore Nguyen, Scott A. Zinck, Tawanda Zimudzi, Erik C. Cook, Scott Zinck, S Showalter, Tawanda J. Zimudzi, Scott Schowalter, Scott A. Showalter, Julianna Simon, S Medina, Adam B. Glick, Julianna Simon, Scott Medina*, 2020, ACS Nano on p. 4061-4073

Ensemble analysis of primary microRNA structure reveals an extensive capacity to deform near the drosha cleavage site

Kaycee A. Quarles, Debashish Sahu, Mallory A. Havens, Ellen R. Forsyth, Christopher Wostenberg, Michelle L. Hastings, Scott A. Showalter, 2013, Biochemistry on p. 795-807

Expanding the proteome of an RNA virus by phosphorylation of an intrinsically disordered viral protein

Daniel G. Cordek, Tayler J. Croom-Perez, Jungwook Hwang, Michele R.S. Hargittai, Chennareddy V. Subba-Reddy, Qingxia Han, Maria Fernanda Lodeiro, Gang Ning, Thomas S. McCrory, Jamie J. Arnold, Hasan Koc, Brett D. Lindenbach, Scott A. Showalter, Craig E. Cameron, 2014, Journal of Biological Chemistry on p. 24397-24416