Scott Showalter

Professor of Chemistry; Professor of Biochemistry and Molecular Biology

Scott Showalter

Research Summary

Biophysical Chemistry applied to solution NMR spectroscopy of partially disordered proteins. NMR studies of protein dynamics coupled with computational and theoretical studies of the coupling between nuclear spin relaxation and molecular motion.

Huck Affiliations

Links

Publication Tags

Proteins Intrinsically Disordered Proteins Phosphorylation Nuclear Magnetic Resonance Rna Polymerase Ii Rna Micrornas Carbon Proline Transcription Factors Phosphoric Monoester Hydrolases Rna Polymerase Iii Switches Double Stranded Rna Experiments Processing Transcription Gene Expression Polymers Entropy Nuclear Magnetic Resonance Spectroscopy Drosophila Melanogaster Magnetic Resonance Spectroscopy Enzymes Ribonuclease Iii

Most Recent Papers

Ultrasound-Guided Cytosolic Protein Delivery <i>via</i> Transient Fluorous Masks.

J Sloand, Toan Nguyen, S Zinck, E Cook, T Zimudzi, Scott Showalter, Adam Glick, Julianna Simon, Scott Medina, 2020, ACS nano on p. 4061-4073

Solution Ensemble of the C-Terminal Domain from the Transcription Factor Pdx1 Resembles an Excluded Volume Polymer

Erik C. Cook, Debashish Sahu, Monique Bastidas, Scott A. Showalter, 2019, Journal of Physical Chemistry B on p. 106-116

Structural Basis for Rare Earth Element Recognition by Methylobacterium extorquens Lanmodulin

Erik C. Cook, Emily R. Featherston, Scott A. Showalter, Joseph Alfred Cotruvo, Jr., 2019, Biochemistry on p. 120-125

Chemical Tools for Studying the Impact of cis/trans Prolyl Isomerization on Signaling

Nathaniel Tate Burkholder, Brenda Medellin, Seema Irani, Wendy Matthews, Scott A. Showalter, Yan Jessie Zhang, 2018, Methods in Enzymology

The use of (13)C Direct-Detect NMR to Characterize Flexible and Disordered Proteins

EC Cook, GA Usher, SA Showalter, 2018, on p. 81-100

Substrate Specificity of the Kinase P-TEFb towards the RNA Polymerase II C-Terminal Domain

Eric B. Gibbs, Tatiana N. Laremore, Grace A. Usher, Bede Portz, Erik C. Cook, Scott A. Showalter, 2017, Biophysical journal on p. 1909-1911

Application of NMR to studies of intrinsically disordered proteins

Eric B. Gibbs, Erik C. Cook, Scott A. Showalter, 2017, Archives of Biochemistry and Biophysics on p. 57-70

Engineering double-stranded RNA binding activity into the Drosha double-stranded RNA binding domain results in a loss of microRNA processing function

Joshua C. Kranick, Durga M. Chadalavada, Debashish Sahu, Scott A. Showalter, 2017, PloS one

Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain

Eric B. Gibbs, Feiyue Lu, Bede Portz, Michael J. Fisher, Brenda P. Medellin, Tatiana N. Laremore, Yan Jessie Zhang, David S. Gilmour, Scott A. Showalter, 2017, Nature communications

Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain

Bede Portz, Feiyue Lu, Eric B. Gibbs, Joshua E. Mayfield, M. Rachel Mehaffey, Yan Jessie Zhang, Jennifer S. Brodbelt, Scott A. Showalter, David S. Gilmour, 2017, Nature communications

Most-Cited Papers

Entropy localization in proteins

Da Wei Li, Scott A. Showalter, Rafael Brüschweiler, 2010, Journal of Physical Chemistry B on p. 16036-16044

The Role of Human Dicer-dsRBD in Processing Small Regulatory RNAs

Christopher Wostenberg, Jeffrey W. Lary, Debashish Sahu, Roderico Acevedo, Kaycee A. Quarles, James L. Cole, Scott A. Showalter, 2012, PloS one

Quantitative biophysical characterization of intrinsically disordered proteins

Eric B. Gibbs, Scott A. Showalter, 2015, Biochemistry on p. 1314-1326

Generating NMR chemical shift assignments of intrinsically disordered proteins using carbon-detected NMR methods

Debashish Sahu, Monique Bastidas, Scott A. Showalter, 2014, Analytical Biochemistry on p. 17-25

Application of NMR to studies of intrinsically disordered proteins

Eric B. Gibbs, Erik C. Cook, Scott A. Showalter, 2017, Archives of Biochemistry and Biophysics on p. 57-70

Carbon-detected <sup>15</sup>N NMR spin relaxation of an intrinsically disordered protein

Chad W. Lawrence, Scott A. Showalter, 2012, Journal of Physical Chemistry Letters on p. 1409-1413

Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain

Eric B. Gibbs, Feiyue Lu, Bede Portz, Michael J. Fisher, Brenda P. Medellin, Tatiana N. Laremore, Yan Jessie Zhang, David S. Gilmour, Scott A. Showalter, 2017, Nature communications

The disordered C-terminus of the RNA Polymerase II phosphatase FCP1 is partially helical in the unbound state

Chad W. Lawrence, Alain Bonny, Scott A. Showalter, 2011, Biochemical and Biophysical Research Communications on p. 461-465

Dynamic origins of differential RNA binding function in two dsRBDs from the miRNA "Microprocessor" complex

Christopher Wostenberg, Kaycee A. Quarles, Scott A. Showalter, 2010, Biochemistry on p. 10728-10736

Expanding the proteome of an RNA virus by phosphorylation of an intrinsically disordered viral protein

Daniel G. Cordek, Tayler J. Croom-Perez, Jungwook Hwang, Michele R.S. Hargittai, Chennareddy V. Subba-Reddy, Qingxia Han, Maria Fernanda Lodeiro, Gang Ning, Thomas S. McCrory, Jamie J. Arnold, Hasan Koc, Brett D. Lindenbach, Scott A. Showalter, Craig E. Cameron, 2014, Journal of Biological Chemistry on p. 24397-24416