Scott Showalter
Professor of Chemistry; Professor of Biochemistry and Molecular Biology
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Chemistry Bldg
University Park, - sas76@psu.edu
- 814-865-2318
Research Summary
Biophysical Chemistry applied to solution NMR spectroscopy of partially disordered proteins. NMR studies of protein dynamics coupled with computational and theoretical studies of the coupling between nuclear spin relaxation and molecular motion.
Huck Affiliations
Links
Publication Tags
Proteins Protein Nuclear Magnetic Resonance Intrinsically Disordered Proteins Rna Phosphorylation Rna Polymerase Ii Carbon Experiments Micrornas Nmr Spectroscopy Proline Lanthanoid Series Elements Magnetic Resonance Spectroscopy Nuclear Magnetic Resonance Spectroscopy Application Masks Polymers Double Stranded Rna Statistical Ensemble Processing Transcription Factors Metals Small Interfering Rna Rna Polymerase IiiMost Recent Papers
Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity
Emery T. Usher, Nafiseh Sabri, Roman Rohac, Amie K. Boal, Tanja Mittag, Scott A. Showalter, 2021, Journal of Biological Chemistry
Mapping invisible epitopes by NMR spectroscopy
Emery T. Usher, Scott A. Showalter, 2020, Journal of Biological Chemistry on p. 17411-17412
Elucidating the Role of Microprocessor Protein DGCR8 in Bending RNA Structures
Suzette A. Pabit, Yen Lin Chen, Emery T. Usher, Erik C. Cook, Lois Pollack, Scott A. Showalter, 2020, Biophysical Journal on p. 2524-2536
An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen
Valerie J. Morley, Clare L. Kinnear, Derek G. Sim, Samantha N. Olson, Lindsey M. Jackson, Elsa Hansen, Grace A. Usher, Scott A. Showalter, Manjunath P. Pai, Robert J. Woods, Andrew F. Read, 2020, eLife on p. 1-17
Reviving Protein-Observed <sup>19</sup>F Lineshape Analysis for Deep Insight into Protein-Ligand Binding Events
Scott A. Showalter, 2020, Biophysical Journal on p. 2333-2335
Ultrasound-guided cytosolic protein delivery via transient fluorous masks
Janna N. Sloand, Theodore T. Nguyen, Scott A. Zinck, Erik C. Cook, Tawanda J. Zimudzi, Scott A. Showalter, Adam B. Glick, Julianna C. Simon, Scott H. Medina, 2020, ACS Nano on p. 4061-4073
Solution Ensemble of the C-Terminal Domain from the Transcription Factor Pdx1 Resembles an Excluded Volume Polymer
Erik C. Cook, Debashish Sahu, Monique Bastidas, Scott A. Showalter, 2019, Journal of Physical Chemistry B on p. 106-116
Structural basis for rare earth element recognition by methylobacterium extorquens lanmodulin
Erik C. Cook, Emily R. Featherston, Scott A. Showalter, Joseph A. Cotruvo, 2019, Biochemistry on p. 120-125
Chemical Tools for Studying the Impact of cis/trans Prolyl Isomerization on Signaling
Nathaniel Tate Burkholder, Brenda Medellin, Seema Irani, Wendy Matthews, Scott A. Showalter, Yan Jessie Zhang, 2018, Methods in Enzymology
The Use of <sup>13</sup>C Direct-Detect NMR to Characterize Flexible and Disordered Proteins
Erik C. Cook, Grace A. Usher, Scott A. Showalter, 2018, on p. 81-100
Most-Cited Papers
Application of NMR to studies of intrinsically disordered proteins
Eric B. Gibbs, Erik C. Cook, Scott A. Showalter, 2017, Archives of Biochemistry and Biophysics on p. 57-70
Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain
Eric B. Gibbs, Feiyue Lu, Bede Portz, Michael J. Fisher, Brenda P. Medellin, Tatiana N. Laremore, Yan Jessie Zhang, David S. Gilmour, Scott A. Showalter, 2017, Nature Communications
Quantitative biophysical characterization of intrinsically disordered proteins
Eric B. Gibbs, Scott A. Showalter, 2015, Biochemistry on p. 1314-1326
The Role of Human Dicer-dsRBD in Processing Small Regulatory RNAs
Christopher Wostenberg, Jeffrey W. Lary, Debashish Sahu, Roderico Acevedo, Kaycee A. Quarles, James L. Cole, Scott A. Showalter, 2012, PLoS One
Structural basis for rare earth element recognition by methylobacterium extorquens lanmodulin
Erik C. Cook, Emily R. Featherston, Scott A. Showalter, Joseph A. Cotruvo, 2019, Biochemistry on p. 120-125
Generating NMR chemical shift assignments of intrinsically disordered proteins using carbon-detected NMR methods
Debashish Sahu, Monique Bastidas, Scott A. Showalter, 2014, Analytical Biochemistry on p. 17-25
Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain
Bede Portz, Feiyue Lu, Eric B. Gibbs, Joshua E. Mayfield, M. Rachel Mehaffey, Yan Jessie Zhang, Jennifer S. Brodbelt, Scott A. Showalter, David S. Gilmour, 2017, Nature Communications
A primer for carbon-detected NMR applications to intrinsically disordered proteins in solution
Monique Bastidas, Eric B. Gibbs, Debashish Sahu, Scott A. Showalter, 2015, Concepts in Magnetic Resonance Part A: Bridging Education and Research on p. 54-66
Carbon-detected <sup>15</sup>N NMR spin relaxation of an intrinsically disordered protein
Chad W. Lawrence, Scott A. Showalter, 2012, Journal of Physical Chemistry Letters on p. 1409-1413
Ensemble analysis of primary microRNA structure reveals an extensive capacity to deform near the drosha cleavage site
Kaycee A. Quarles, Debashish Sahu, Mallory A. Havens, Ellen R. Forsyth, Christopher Wostenberg, Michelle L. Hastings, Scott A. Showalter, 2013, Biochemistry on p. 795-807
News Articles Featuring Scott Showalter
Jul 01, 2021
How does a regulatory protein know where to bind to modulate insulin production?
Some proteins in the body ensure that genes are turned on and off at the correct times. Understanding where speckle-type POZ protein (SPOP) binds may help researchers predict what predisposes individuals to develop diabetes and clarify how SPOP regulates other important proteins. In a recent study, a team of researchers from Penn State and St. Jude Children’s Research Hospital imaged the proteins and determined just how this important interaction occurs.
Full Article
Dec 01, 2020
'Anti-antibiotic' allows for use of antibiotics without driving resistance
An inexpensive, FDA-approved drug — cholestyramine — taken in conjunction with an antibiotic prevents the antibiotic from driving antimicrobial resistance, according to new research by scientists at Penn State and the University of Michigan. The team’s findings appear today (Dec. 1) in the journal eLife.
Full Article