Scott Showalter

Professor of Chemistry; Professor of Biochemistry and Molecular Biology

Scott Showalter

Research Summary

Biophysical Chemistry applied to solution NMR spectroscopy of partially disordered proteins. NMR studies of protein dynamics coupled with computational and theoretical studies of the coupling between nuclear spin relaxation and molecular motion.

Huck Affiliations

Links

Publication Tags

Proteins Phosphorylation Nuclear Magnetic Resonance Intrinsically Disordered Proteins Rna Polymerase Ii Carbon Rna Proline Rna Polymerase Iii Transcription Factors Phosphoric Monoester Hydrolases Experiments Micrornas Switches Double Stranded Rna Drosophila Melanogaster Transcription Gene Expression Polymers Entropy Nuclear Magnetic Resonance Spectroscopy Processing Genes Magnetic Resonance Spectroscopy Mass Spectrometry

Most Recent Papers

Solution Ensemble of the C-Terminal Domain from the Transcription Factor Pdx1 Resembles an Excluded Volume Polymer

Erik C. Cook, Debashish Sahu, Monique Bastidas, Scott A. Showalter, 2019, Journal of Physical Chemistry B on p. 106-116

Structural Basis for Rare Earth Element Recognition by Methylobacterium extorquens Lanmodulin

Erik C. Cook, Emily R. Featherston, Scott A. Showalter, Joseph Alfred Cotruvo, Jr., 2019, Biochemistry on p. 120-125

Chemical Tools for Studying the Impact of cis/trans Prolyl Isomerization on Signaling

Nathaniel Tate Burkholder, Brenda Medellin, Seema Irani, Wendy Matthews, Scott A. Showalter, Yan Jessie Zhang, 2018, Methods in Enzymology

Substrate Specificity of the Kinase P-TEFb towards the RNA Polymerase II C-Terminal Domain

Eric B. Gibbs, Tatiana N. Laremore, Grace A. Usher, Bede Portz, Erik C. Cook, Scott A. Showalter, 2017, Biophysical journal on p. 1909-1911

Application of NMR to studies of intrinsically disordered proteins

Eric B. Gibbs, Erik C. Cook, Scott A. Showalter, 2017, Archives of Biochemistry and Biophysics on p. 57-70

Engineering double-stranded RNA binding activity into the Drosha double-stranded RNA binding domain results in a loss of microRNA processing function

Joshua C. Kranick, Durga M. Chadalavada, Debashish Sahu, Scott A. Showalter, 2017, PloS one

Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain

Eric B. Gibbs, Feiyue Lu, Bede Portz, Michael J. Fisher, Brenda P. Medellin, Tatiana N. Laremore, Yan Jessie Zhang, David S. Gilmour, Scott A. Showalter, 2017, Nature communications

Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain

Bede Portz, Feiyue Lu, Eric B. Gibbs, Joshua E. Mayfield, M. Rachel Mehaffey, Yan Jessie Zhang, Jennifer S. Brodbelt, Scott A. Showalter, David S. Gilmour, 2017, Nature communications

Quantification of Compactness and Local Order in the Ensemble of the Intrinsically Disordered Protein FCP1

Eric B. Gibbs, Scott A. Showalter, 2016, Journal of Physical Chemistry B on p. 8960-8969

Binding by TRBP-dsRBD2 Does Not Induce Bending of Double-Stranded RNA

Roderico Acevedo, Declan Evans, Katheryn A. Penrod, Scott A. Showalter, 2016, Biophysical journal on p. 2610-2617

Most-Cited Papers

Entropy localization in proteins

Da Wei Li, Scott A. Showalter, Rafael Brüschweiler, 2010, Journal of Physical Chemistry B on p. 16036-16044

Generating NMR chemical shift assignments of intrinsically disordered proteins using carbon-detected NMR methods

Debashish Sahu, Monique Bastidas, Scott A. Showalter, 2014, Analytical Biochemistry on p. 17-25

Application of NMR to studies of intrinsically disordered proteins

Eric B. Gibbs, Erik C. Cook, Scott A. Showalter, 2017, Archives of Biochemistry and Biophysics on p. 57-70

Carbon-detected <sup>15</sup>N NMR spin relaxation of an intrinsically disordered protein

Chad W. Lawrence, Scott A. Showalter, 2012, Journal of Physical Chemistry Letters on p. 1409-1413

Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain

Eric B. Gibbs, Feiyue Lu, Bede Portz, Michael J. Fisher, Brenda P. Medellin, Tatiana N. Laremore, Yan Jessie Zhang, David S. Gilmour, Scott A. Showalter, 2017, Nature communications

Dynamic origins of differential RNA binding function in two dsRBDs from the miRNA "Microprocessor" complex

Christopher Wostenberg, Kaycee A. Quarles, Scott A. Showalter, 2010, Biochemistry on p. 10728-10736

The disordered C-terminus of the RNA Polymerase II phosphatase FCP1 is partially helical in the unbound state

Chad W. Lawrence, Alain Bonny, Scott A. Showalter, 2011, Biochemical and Biophysical Research Communications on p. 461-465

Expanding the proteome of an RNA virus by phosphorylation of an intrinsically disordered viral protein

Daniel G. Cordek, Tayler J. Croom-Perez, Jungwook Hwang, Michele R.S. Hargittai, Chennareddy V. Subba-Reddy, Qingxia Han, Maria Fernanda Lodeiro, Gang Ning, Thomas S. McCrory, Jamie J. Arnold, Hasan Koc, Brett D. Lindenbach, Scott A. Showalter, Craig E. Cameron, 2014, Journal of Biological Chemistry on p. 24397-24416

A primer for carbon-detected NMR applications to intrinsically disordered proteins in solution

Monique Bastidas, Eric B. Gibbs, Debashish Sahu, Scott A. Showalter, 2015, Concepts in Magnetic Resonance Part A: Bridging Education and Research on p. 54-66

Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain

Bede Portz, Feiyue Lu, Eric B. Gibbs, Joshua E. Mayfield, M. Rachel Mehaffey, Yan Jessie Zhang, Jennifer S. Brodbelt, Scott A. Showalter, David S. Gilmour, 2017, Nature communications