Scott Showalter
Professor of Chemistry; Professor of Biochemistry and Molecular Biology

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Chemistry Bldg
University Park, - sas76@psu.edu
- 814-865-2318
Research Summary
Biophysical Chemistry applied to solution NMR spectroscopy of partially disordered proteins. NMR studies of protein dynamics coupled with computational and theoretical studies of the coupling between nuclear spin relaxation and molecular motion.
Huck Affiliations
Links
Publication Tags
Proteins Intrinsically Disordered Proteins Nuclear Magnetic Resonance Rna Phosphorylation Rna Polymerase Ii Double Stranded Rna Micrornas Carbon Experiments Proline Lanthanoid Series Elements Processing Transcription Factors Rna Polymerase Iii Polymers Enzymes Metals Drosophila Melanogaster Gene Expression Magnetic Resonance Spectroscopy Small Interfering Rna Amino Acids Nuclear Magnetic Resonance Spectroscopy Anti Bacterial AgentsMost Recent Papers
An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen
Valerie J. Morley, Clare L. Kinnear, Derek G. Sim, Samantha N. Olson, Lindsey M. Jackson, Elsa Hansen, Grace A. Usher, Scott A. Showalter, Manjunath P. Pai, Robert J. Woods, Andrew F. Read, 2020, eLife
Reviving Protein-Observed <sup>19</sup>F Lineshape Analysis for Deep Insight into Protein-Ligand Binding Events
Scott A. Showalter, 2020, Biophysical Journal on p. 2333-2335
Elucidating the Role of Microprocessor Protein DGCR8 in Bending RNA Structures
S.A. Pabit, Y.-L. Chen, E.T. Usher, E.C. Cook, L. Pollack, Scott Showalter, 2020, Biophys. J. on p. 2524-2536
Solution Ensemble of the C-Terminal Domain from the Transcription Factor Pdx1 Resembles an Excluded Volume Polymer
Erik C. Cook, Debashish Sahu, Monique Bastidas, Scott A. Showalter, 2019, Journal of Physical Chemistry B on p. 106-116
Structural basis for rare earth element recognition by methylobacterium extorquens lanmodulin
Erik C. Cook, Emily R. Featherston, Scott A. Showalter, Joseph Alfred Cotruvo, Jr., 2019, Biochemistry on p. 120-125
Chemical Tools for Studying the Impact of cis/trans Prolyl Isomerization on Signaling
Nathaniel Tate Burkholder, Brenda Medellin, Seema Irani, Wendy Matthews, Scott A. Showalter, Yan Jessie Zhang, 2018, Methods in Enzymology
The use of (13)C Direct-Detect NMR to Characterize Flexible and Disordered Proteins
EC Cook, GA Usher, SA Showalter, 2018, on p. 81-100
Substrate Specificity of the Kinase P-TEFb towards the RNA Polymerase II C-Terminal Domain
Eric B. Gibbs, Tatiana N. Laremore, Grace A. Usher, Bede Portz, Erik C. Cook, Scott A. Showalter, 2017, Biophysical Journal on p. 1909-1911
Application of NMR to studies of intrinsically disordered proteins
Eric B. Gibbs, Erik C. Cook, Scott A. Showalter, 2017, Archives of Biochemistry and Biophysics on p. 57-70
Engineering double-stranded RNA binding activity into the Drosha double-stranded RNA binding domain results in a loss of microRNA processing function
Joshua C. Kranick, Durga M. Chadalavada, Debashish Sahu, Scott A. Showalter, 2017, PLoS One
Most-Cited Papers
Application of NMR to studies of intrinsically disordered proteins
Eric B. Gibbs, Erik C. Cook, Scott A. Showalter, 2017, Archives of Biochemistry and Biophysics on p. 57-70
Quantitative biophysical characterization of intrinsically disordered proteins
Eric B. Gibbs, Scott A. Showalter, 2015, Biochemistry on p. 1314-1326
The Role of Human Dicer-dsRBD in Processing Small Regulatory RNAs
Christopher Wostenberg, Jeffrey W. Lary, Debashish Sahu, Roderico Acevedo, Kaycee A. Quarles, James L. Cole, Scott A. Showalter, 2012, PLoS One
Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain
Eric B. Gibbs, Feiyue Lu, Bede Portz, Michael J. Fisher, Brenda P. Medellin, Tatiana N. Laremore, Yan Jessie Zhang, David S. Gilmour, Scott A. Showalter, 2017, Nature Communications
Generating NMR chemical shift assignments of intrinsically disordered proteins using carbon-detected NMR methods
Debashish Sahu, Monique Bastidas, Scott A. Showalter, 2014, Analytical Biochemistry on p. 17-25
A primer for carbon-detected NMR applications to intrinsically disordered proteins in solution
Monique Bastidas, Eric B. Gibbs, Debashish Sahu, Scott A. Showalter, 2015, Concepts in Magnetic Resonance Part A: Bridging Education and Research on p. 54-66
Structural basis for rare earth element recognition by methylobacterium extorquens lanmodulin
Erik C. Cook, Emily R. Featherston, Scott A. Showalter, Joseph Alfred Cotruvo, Jr., 2019, Biochemistry on p. 120-125
Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain
Bede Portz, Feiyue Lu, Eric B. Gibbs, Joshua E. Mayfield, M. Rachel Mehaffey, Yan Jessie Zhang, Jennifer S. Brodbelt, Scott A. Showalter, David S. Gilmour, 2017, Nature Communications
Carbon-detected <sup>15</sup>N NMR spin relaxation of an intrinsically disordered protein
Chad W. Lawrence, Scott A. Showalter, 2012, Journal of Physical Chemistry Letters on p. 1409-1413
Ensemble analysis of primary microRNA structure reveals an extensive capacity to deform near the drosha cleavage site
Kaycee A. Quarles, Debashish Sahu, Mallory A. Havens, Ellen R. Forsyth, Christopher Wostenberg, Michelle L. Hastings, Scott A. Showalter, 2013, Biochemistry on p. 795-807