Scott Showalter

Professor of Chemistry; Professor of Biochemistry and Molecular Biology

Scott Showalter

Research Summary

Biophysical Chemistry applied to solution NMR spectroscopy of partially disordered proteins. NMR studies of protein dynamics coupled with computational and theoretical studies of the coupling between nuclear spin relaxation and molecular motion.

Huck Affiliations

Links

Publication Tags

Proteins Intrinsically Disordered Proteins Nuclear Magnetic Resonance Rna Phosphorylation Rna Polymerase Ii Double Stranded Rna Micrornas Carbon Experiments Proline Lanthanoid Series Elements Processing Transcription Factors Rna Polymerase Iii Polymers Enzymes Metals Drosophila Melanogaster Gene Expression Magnetic Resonance Spectroscopy Small Interfering Rna Amino Acids Nuclear Magnetic Resonance Spectroscopy Anti Bacterial Agents

Most Recent Papers

An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen

Valerie J. Morley, Clare L. Kinnear, Derek G. Sim, Samantha N. Olson, Lindsey M. Jackson, Elsa Hansen, Grace A. Usher, Scott A. Showalter, Manjunath P. Pai, Robert J. Woods, Andrew F. Read, 2020, eLife

Reviving Protein-Observed <sup>19</sup>F Lineshape Analysis for Deep Insight into Protein-Ligand Binding Events

Scott A. Showalter, 2020, Biophysical Journal on p. 2333-2335

Elucidating the Role of Microprocessor Protein DGCR8 in Bending RNA Structures

S.A. Pabit, Y.-L. Chen, E.T. Usher, E.C. Cook, L. Pollack, Scott Showalter, 2020, Biophys. J. on p. 2524-2536

Solution Ensemble of the C-Terminal Domain from the Transcription Factor Pdx1 Resembles an Excluded Volume Polymer

Erik C. Cook, Debashish Sahu, Monique Bastidas, Scott A. Showalter, 2019, Journal of Physical Chemistry B on p. 106-116

Structural basis for rare earth element recognition by methylobacterium extorquens lanmodulin

Erik C. Cook, Emily R. Featherston, Scott A. Showalter, Joseph Alfred Cotruvo, Jr., 2019, Biochemistry on p. 120-125

Chemical Tools for Studying the Impact of cis/trans Prolyl Isomerization on Signaling

Nathaniel Tate Burkholder, Brenda Medellin, Seema Irani, Wendy Matthews, Scott A. Showalter, Yan Jessie Zhang, 2018, Methods in Enzymology

The use of (13)C Direct-Detect NMR to Characterize Flexible and Disordered Proteins

EC Cook, GA Usher, SA Showalter, 2018, on p. 81-100

Substrate Specificity of the Kinase P-TEFb towards the RNA Polymerase II C-Terminal Domain

Eric B. Gibbs, Tatiana N. Laremore, Grace A. Usher, Bede Portz, Erik C. Cook, Scott A. Showalter, 2017, Biophysical Journal on p. 1909-1911

Application of NMR to studies of intrinsically disordered proteins

Eric B. Gibbs, Erik C. Cook, Scott A. Showalter, 2017, Archives of Biochemistry and Biophysics on p. 57-70

Engineering double-stranded RNA binding activity into the Drosha double-stranded RNA binding domain results in a loss of microRNA processing function

Joshua C. Kranick, Durga M. Chadalavada, Debashish Sahu, Scott A. Showalter, 2017, PLoS One

Most-Cited Papers

Application of NMR to studies of intrinsically disordered proteins

Eric B. Gibbs, Erik C. Cook, Scott A. Showalter, 2017, Archives of Biochemistry and Biophysics on p. 57-70

Quantitative biophysical characterization of intrinsically disordered proteins

Eric B. Gibbs, Scott A. Showalter, 2015, Biochemistry on p. 1314-1326

The Role of Human Dicer-dsRBD in Processing Small Regulatory RNAs

Christopher Wostenberg, Jeffrey W. Lary, Debashish Sahu, Roderico Acevedo, Kaycee A. Quarles, James L. Cole, Scott A. Showalter, 2012, PLoS One

Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain

Eric B. Gibbs, Feiyue Lu, Bede Portz, Michael J. Fisher, Brenda P. Medellin, Tatiana N. Laremore, Yan Jessie Zhang, David S. Gilmour, Scott A. Showalter, 2017, Nature Communications

Generating NMR chemical shift assignments of intrinsically disordered proteins using carbon-detected NMR methods

Debashish Sahu, Monique Bastidas, Scott A. Showalter, 2014, Analytical Biochemistry on p. 17-25

A primer for carbon-detected NMR applications to intrinsically disordered proteins in solution

Monique Bastidas, Eric B. Gibbs, Debashish Sahu, Scott A. Showalter, 2015, Concepts in Magnetic Resonance Part A: Bridging Education and Research on p. 54-66

Structural basis for rare earth element recognition by methylobacterium extorquens lanmodulin

Erik C. Cook, Emily R. Featherston, Scott A. Showalter, Joseph Alfred Cotruvo, Jr., 2019, Biochemistry on p. 120-125

Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain

Bede Portz, Feiyue Lu, Eric B. Gibbs, Joshua E. Mayfield, M. Rachel Mehaffey, Yan Jessie Zhang, Jennifer S. Brodbelt, Scott A. Showalter, David S. Gilmour, 2017, Nature Communications

Carbon-detected <sup>15</sup>N NMR spin relaxation of an intrinsically disordered protein

Chad W. Lawrence, Scott A. Showalter, 2012, Journal of Physical Chemistry Letters on p. 1409-1413

Ensemble analysis of primary microRNA structure reveals an extensive capacity to deform near the drosha cleavage site

Kaycee A. Quarles, Debashish Sahu, Mallory A. Havens, Ellen R. Forsyth, Christopher Wostenberg, Michelle L. Hastings, Scott A. Showalter, 2013, Biochemistry on p. 795-807