Neela Yennawar

Director, X-Ray Crystallography and Automated Biological Calorimetry Core Facilities

Neela Yennawar

Research Summary

Biological calorimetry, protein characterization, molecular modeling, X-ray crystallography, and small-angle X-ray scattering.

Huck Affiliations

Publication Tags

Rna Enzymes X Ray Crystallography Tea Proteins Biosynthesis Glutamic Acid Catalytic Rna Glutaminase Lipase Oxidation Reduction Quinolinic Acid Transaminases Alpha Hydroxyglutarate Theaflavin X Rays Transfer Rna Rna Folding Ions Nucleotides Catalysis In Vitro Techniques Catalytic Domain Dihydroxyacetone Phosphate Iron

Most Recent Papers

Single-nucleotide control of tRNA folding cooperativity under near-cellular conditions

Kathleen A. Leamy, Ryota Yamagami, Neela H. Yennawar, Philip C. Bevilacqua, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 23075-23082

Enhanced performance and stability in DNA-perovskite heterostructure-based solar cells

Yuchen Hou, Kai Wang, Dong Yang, Yuanyuan Jiang, Neela Yennawar, Ke Wang, Mohan Sanghadasa, Congcong Wu, Shashank Priya, 2019, ACS Energy Letters on p. 2646-2655

An Unexpected Species Determined by X-ray Crystallography that May Represent an Intermediate in the Reaction Catalyzed by Quinolinate Synthase

Olga A. Esakova, Alexey Silakov, Tyler L. Grove, Douglas M. Warui, Neela H. Yennawar, Squire J. Booker, 2019, Journal of the American Chemical Society on p. 14142-14151

Physicochemical interactions with (-)-epigallocatechin-3-gallate drive structural modification of celiac-associated peptide α<sub>2</sub>-gliadin (57-89) at physiological conditions

Charlene B. Van Buiten, Neela H. Yennawar, Carlos N. Pacheco, Emmanuel Hatzakis, Ryan J. Elias, 2019, Food and Function on p. 2997-3007

Structures of Class Id Ribonucleotide Reductase Catalytic Subunits Reveal a Minimal Architecture for Deoxynucleotide Biosynthesis

Hannah R. Rose, Ailiena O. Maggiolo, Molly J. McBride, Gavin M. Palowitch, Maria Eirini Pandelia, Katherine M. Davis, Neela H. Yennawar, Amie K. Boal, 2019, Biochemistry on p. 1845-1860

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale, Diana D. Shi, Januka Khanal, Abhishek A. Chakraborty, Kristopher A. Sarosiek, Kimberly J. Briggs, Alissa K. Robbins, Tomasz Sewastianik, Sarah J. Shareef, Benjamin A. Olenchock, Seth J. Parker, Kensuke Tateishi, Jessica B. Spinelli, Mirazul Islam, Marcia C. Haigis, Ryan E. Looper, Keith L. Ligon, Bradley E. Bernstein, Ruben D. Carrasco, Daniel P. Cahill, John M. Asara, Christian M. Metallo, Neela H. Yennawar, Matthew G. Vander Heiden, William G. Kaelin, 2018, Cell on p. 101-116.e25

Cooperative RNA Folding under Cellular Conditions Arises from Both Tertiary Structure Stabilization and Secondary Structure Destabilization

Kathleen A. Leamy, Neela H. Yennawar, Philip C. Bevilacqua, 2017, Biochemistry on p. 3422-3433

The GlcN6P cofactor plays multiple catalytic roles in the glmS ribozyme

Jamie L. Bingaman, Sixue Zhang, David R. Stevens, Neela H. Yennawar, Sharon Hammes-Schiffer, Philip C. Bevilacqua, 2017, Nature Chemical Biology on p. 439-445

Inhibition of pancreatic lipase by black tea theaflavins

Shannon L. Glisan, Kimberly A. Grove, Neela H. Yennawar, Joshua D. Lambert, 2017, Food Chemistry on p. 296-300

Structure of Quinolinate Synthase from Pyrococcus horikoshii in the Presence of Its Product, Quinolinic Acid

Olga A. Esakova, Alexey Silakov, Tyler L. Grove, Allison H. Saunders, Martin I. McLaughlin, Neela Yennawar, Squire J. Booker, 2016, Journal of the American Chemical Society on p. 7224-7227

Most-Cited Papers

Structural basis for methyl transfer by a radical SAM enzyme

Amie Kathleen Boal, Tyler L. Grove, Monica I. McLaughlin, Neela Yennawar, Squire J. Booker, Amy C. Rosenzweig, 2011, Science on p. 1089-1092

Structural basis for entropy-driven cellulose binding by a type-A cellulose-binding module (CBM) and bacterial expansin

Nikolaos Georgelis, Neela H. Yennawar, Daniel J. Cosgrove, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. 14830-14835

Molecular crowding favors reactivity of a human ribozyme under physiological ionic conditions

Christopher A. Strulson, Neela Yennawar, Robert P. Rambo, Philip C. Bevilacqua, 2013, Biochemistry on p. 8187-8197

Precise Manipulation and Patterning of Protein Crystals for Macromolecular Crystallography Using Surface Acoustic Waves

Feng Guo, Weijie Zhou, Peng Li, Zhangming Mao, Neela H. Yennawar, Jarrod B. French, Tony Jun Huang, 2015, Small on p. 2733-2737

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale, Diana D. Shi, Januka Khanal, Abhishek A. Chakraborty, Kristopher A. Sarosiek, Kimberly J. Briggs, Alissa K. Robbins, Tomasz Sewastianik, Sarah J. Shareef, Benjamin A. Olenchock, Seth J. Parker, Kensuke Tateishi, Jessica B. Spinelli, Mirazul Islam, Marcia C. Haigis, Ryan E. Looper, Keith L. Ligon, Bradley E. Bernstein, Ruben D. Carrasco, Daniel P. Cahill, John M. Asara, Christian M. Metallo, Neela H. Yennawar, Matthew G. Vander Heiden, William G. Kaelin, 2018, Cell on p. 101-116.e25

The GlcN6P cofactor plays multiple catalytic roles in the glmS ribozyme

Jamie L. Bingaman, Sixue Zhang, David R. Stevens, Neela H. Yennawar, Sharon Hammes-Schiffer, Philip C. Bevilacqua, 2017, Nature Chemical Biology on p. 439-445

Inhibition of pancreatic lipase by black tea theaflavins

Shannon L. Glisan, Kimberly A. Grove, Neela H. Yennawar, Joshua D. Lambert, 2017, Food Chemistry on p. 296-300

Cooperative RNA Folding under Cellular Conditions Arises from Both Tertiary Structure Stabilization and Secondary Structure Destabilization

Kathleen A. Leamy, Neela H. Yennawar, Philip C. Bevilacqua, 2017, Biochemistry on p. 3422-3433

X-ray crystal structure and small-angle X-ray scattering of sheep liver sorbitol dehydrogenase

Hemant Yennawar, Magda Mller, Richard Gillilan, Neela Yennawar, 2011, Acta Crystallographica Section D: Biological Crystallography on p. 440-446

Kinetic and structural characterization of dihydrofolate reductase from Streptococcus pneumoniae

Jeeyeon Lee, Neela Yennawar, Jongsik Gam, Stephen Benkovic, 2010, Biochemistry on p. 195-206