Neela Yennawar
Director, X-Ray Crystallography and Automated Biological Calorimetry Core Facilities; Research Professor
-
0088 Althouse Lab
University Park, PA 16802 - She/Her
- nhy1@psu.edu
- 814-863-9387
Research Summary
Biological calorimetry, protein characterization, molecular modeling, X-ray crystallography, and small-angle X-ray scattering.
Huck Affiliations
Publication Tags
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Proteins Rna Enzymes Protein Perovskite Choloylglycine Hydrolase Crystallization Dna Transfer Rna Tea Alpha Hydroxyglutarate Heterojunctions Vaccines Acoustics Heme Glutamic Acid Microfluidics Thermodynamics Theaflavin Lactobacillus Johnsonii Glutaminase Crystallography Oxidation Reduction Solar Cells SonicationMost Recent Publications
Oxygen-selective regulation of cyclic di-GMP synthesis by a globin coupled sensor with a shortened linking domain modulates Shewanella sp. ANA-3 biofilm
Ariel Schuelke-Sanchez, Neela H. Yennawar, Emily E. Weinert, 2024, Journal of Inorganic Biochemistry
Disordered regions in proteusin peptides guide post-translational modification by a flavin-dependent RiPP brominase
Nguyet A. Nguyen, F. N.U. Vidya, Neela H. Yennawar, Hongwei Wu, Andrew C. McShan, Vinayak Agarwal, 2024, Nature Communications on p. 1265
Computer-aided design, syntheses, and ITC binding data of novel flavanone derivatives for use as potential inhibitors of the papain-like protease of COVID-19
Anna J. Sigmon, Eleanora Margulis, Christy George, Tatiana N. Laremore, Hamzah Al-Quaid, Julia Fecko, Neela H. Yennawar, 2023, Results in Chemistry
Enhanced rare-earth separation with a metal-sensitive lanmodulin dimer
Joseph A. Mattocks, Jonathan J. Jung, Chi Yun Lin, Ziye Dong, Neela H. Yennawar, E Featherson, Emily R. Featherston, Christina S. Kang-Yun, Timothy A. Hamilton, Dan M. Park, Amie Boal, Joseph A. Cotruvo, J Cotruvo Jr., 2023, Nature on p. 87-93
Adaptation-Proof SARS-CoV-2 Vaccine Design
Yashavantha L. Vishweshwaraiah, Brianna Hnath, Brendan Rackley, Jian Wang, Abhinay Gontu, Morgan Chandler, Kirill A. Afonin, Suresh V. Kuchipudi, Neil Christensen, Neela H. Yennawar, Nikolay V. Dokholyan, 2022, Advanced Functional Materials
The Metabolome Weakens RNA Thermodynamic Stability and Strengthens RNA Chemical Stability
Jacob P. Sieg, Lauren N. McKinley, Melanie J. Huot, Neela H. Yennawar, Philip C. Bevilacqua, 2022, Biochemistry on p. 2579-2591
Enteroviral 2C protein is an RNA-stimulated ATPase and uses a two-step mechanism for binding to RNA and ATP
Calvin Yeager, Griffin Carter, David W. Gohara, Neela H. Yennawar, Eric J. Enemark, Jamie J. Arnold, Craig E. Cameron, 2022, Nucleic Acids Research on p. 11775-11798
Bio-inspired strategies for next-generation perovskite solar mobile power sources
Jungjin Yoon, Yuchen Hou, Abbey Marie Knoepfel, Dong Yang, Tao Ye, Luyao Zheng, Neela Yennawar, Mohan Sanghadasa, Shashank Priya, Kai Wang, 2021, Chemical Society Reviews on p. 12915-12984
Heme-Edge Residues Modulate Signal Transduction within a Bifunctional Homo-Dimeric Sensor Protein
Dayna Patterson, Yilin Liu, Sayan Das, Neela H. Yennawar, Jean-Paul Armache, James Kincaid, Emily E. Weinert, 2021, Biochemistry on p. 3801-3812
Cocrystalline Polymer Films Exhibiting Second-Order Nonlinear Optical Properties
Yifan Xu, Rui Zu, Neela H. Yennawar, Venkatraman Gopalan, Robert J. Hickey, 2021, ACS Macro Letters on p. 1216-1222
Most-Cited Papers
Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma
Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale, Diana D. Shi, Januka Khanal, Abhishek A. Chakraborty, Kristopher A. Sarosiek, Kimberly J. Briggs, Alissa K. Robbins, Tomasz Sewastianik, Sarah J. Shareef, Benjamin A. Olenchock, Seth J. Parker, Kensuke Tateishi, Jessica B. Spinelli, Mirazul Islam, Marcia C. Haigis, Ryan E. Looper, Keith L. Ligon, Bradley E. Bernstein, Ruben D. Carrasco, Daniel P. Cahill, John M. Asara, Christian M. Metallo, Neela H. Yennawar, Matthew G. Vander Heiden, William G. Kaelin, 2018, Cell on p. 101-116.e25
Inhibition of pancreatic lipase by black tea theaflavins: Comparative enzymology and in silico modeling studies
Shannon L. Glisan, Kimberly A. Grove, Neela H. Yennawar, Joshua D. Lambert, 2017, Food Chemistry on p. 296-300
Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate
Sang Ah Kim, Jiang Zhu, Neela Yennawar, Priit Eek, Song Tan, 2020, Molecular Cell on p. 903-914.e4
Precise Manipulation and Patterning of Protein Crystals for Macromolecular Crystallography Using Surface Acoustic Waves
Feng Guo, Weijie Zhou, Peng Li, Zhangming Mao, Neela H. Yennawar, Jarrod B. French, Tony Jun Huang, 2015, Small on p. 2733-2737
Enhanced performance and stability in DNA-perovskite heterostructure-based solar cells
Yuchen Hou, Kai Wang, Dong Yang, Yuanyuan Jiang, Neela Yennawar, Ke Wang, Mohan Sanghadasa, Congcong Wu, Shashank Priya, 2019, ACS Energy Letters on p. 2646-2655
The GlcN6P cofactor plays multiple catalytic roles in the glmS ribozyme
Jamie L. Bingaman, Sixue Zhang, David R. Stevens, Neela H. Yennawar, Sharon Hammes-Schiffer, Philip C. Bevilacqua, 2017, Nature Chemical Biology on p. 439-445
Cooperative RNA Folding under Cellular Conditions Arises from Both Tertiary Structure Stabilization and Secondary Structure Destabilization
Kathleen A. Leamy, Neela H. Yennawar, Philip C. Bevilacqua, 2017, Biochemistry on p. 3422-3433
Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA
Michael DiMarzio, Brigida Rusconi, Neela H. Yennawar, Mark Eppinger, Andrew D. Patterson, Edward G. Dudley, 2017, PLoS One
Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB
Olga A. Esakova, Tyler Grove, Neela H. Yennawar, Arthur Arcinas, Bo Wang, Wang, Carsten Krebs, Steven Almo, Squire Booker, 2021, Nature on p. 566-570
Enhanced rare-earth separation with a metal-sensitive lanmodulin dimer
Joseph A. Mattocks, Jonathan J. Jung, Chi Yun Lin, Ziye Dong, Neela H. Yennawar, E Featherson, Emily R. Featherston, Christina S. Kang-Yun, Timothy A. Hamilton, Dan M. Park, Amie Boal, Joseph A. Cotruvo, J Cotruvo Jr., 2023, Nature on p. 87-93
News Articles Featuring Neela Yennawar
Feb 28, 2024
New single molecule biophysics equipment expands research capability
A new addition to the Huck's instrumentation portfolio is expanding the options available to life science researchers, and uses powerful lasers as tweezers to manipulate individual molecules..
Full Article
Jan 25, 2024
Undergraduate research may contribute to COVID-19 treatments
Brandywine undergraduates worked with professor to investigate potential new therapies to inhibit an enzyme that helps the coronavirus replicate
Full Article
Jun 26, 2023
Neela Yennawar and Scott Lindner selected as 2023 Huck Leadership Fellows
Launched in 2022, the Huck Leadership Fellows Program was developed for faculty members seeking to sharpen their leadership skills with an opportunity for exposure to senior leadership within the interdisciplinary research unit.
Full Article
May 31, 2023
A protein mines, sorts rare earths better than humans, paving way for green tech
Rare earth elements, like neodymium and dysprosium, are a critical component to almost all modern technologies, from smartphones to hard drives, but they are notoriously hard to separate from the Earth’s crust and from one another.
Full Article
Oct 18, 2022
Newly engineered protein could be used to develop adaptation-proof COVID vaccine
A vaccine design approach that could protect against new variants of SARS-CoV-2 — the virus that causes COVID-19 — but also potentially protects against other coronaviruses is one step closer to reality as a result of research at Penn State College of Medicine.
Full Article
Jan 13, 2022
Core facilities director brings more than technical advice to research
Directors of the core facilities at Penn State’s Huck Institutes of the Life Sciences are more than expert technicians — they are also researchers in their own right. And though their unique contributions are not always consistently recognized within the broader community, faculty researchers who work in the core facilities are well aware of these unsung heroes' many impressive insights.
Full Article
Aug 20, 2019
Penn State Chemistry Alum Recognized with Young Scientists Award
Kathleen Leamy has been awarded the 2019 Gordon Hammes Scholar Award, based on a 2018 article she co-authored with the Huck Institutes' Neela Yennawar and Phillip Bevilacqua.
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