Neela Yennawar
Director, X-Ray Crystallography and Automated Biological Calorimetry Core Facilities; Research Professor

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0088 Althouse Lab
University Park, PA 16802 - She/Her
- nhy1@psu.edu
- 814-863-9387
Research Summary
Biological calorimetry, protein characterization, molecular modeling, X-ray crystallography, and small-angle X-ray scattering.
Huck Affiliations
Publication Tags
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Proteins Rna Enzymes Protein Catalytic Rna Perovskite Genes Choloylglycine Hydrolase Crystallography Crystallization Dna X Ray Crystallography Heme Transfer Rna Glycols Tea Glutaminase Sonication Vaccines Oxidation Reduction Solar Cells Carbohydrates Theaflavin Thermodynamics WeightMost Recent Publications
Adaptation-Proof SARS-CoV-2 Vaccine Design
Yashavantha L. Vishweshwaraiah, Brianna Hnath, Brendan Rackley, Jian Wang, Abhinay Gontu, Morgan Chandler, Kirill A. Afonin, Suresh V. Kuchipudi, Neil Christensen, Neela H. Yennawar, Nikolay V. Dokholyan, 2022, Advanced Functional Materials
The Metabolome Weakens RNA Thermodynamic Stability and Strengthens RNA Chemical Stability
Jacob P. Sieg, Lauren N. McKinley, Melanie J. Huot, Neela H. Yennawar, Philip C. Bevilacqua, 2022, Biochemistry on p. 2579-2591
Enteroviral 2C protein is an RNA-stimulated ATPase and uses a two-step mechanism for binding to RNA and ATP
Calvin Yeager, Griffin Carter, David W. Gohara, Neela H. Yennawar, Eric J. Enemark, Jamie J. Arnold, Craig E. Cameron, 2022, Nucleic Acids Research on p. 11775-11798
Bio-inspired strategies for next-generation perovskite solar mobile power sources
Jungjin Yoon, Yuchen Hou, Abbey Marie Knoepfel, Dong Yang, Tao Ye, Luyao Zheng, Neela Yennawar, Mohan Sanghadasa, Shashank Priya, Kai Wang, 2021, Chemical Society Reviews on p. 12915-12984
Heme-Edge Residues Modulate Signal Transduction within a Bifunctional Homo-Dimeric Sensor Protein
Dayna Patterson, Yilin Liu, Sayan Das, Neela H. Yennawar, Jean-Paul Armache, James Kincaid, Emily E. Weinert, 2021, Biochemistry on p. 3801-3812
Cocrystalline Polymer Films Exhibiting Second-Order Nonlinear Optical Properties
Yifan Xu, Rui Zu, Neela H. Yennawar, Venkatraman Gopalan, Robert J. Hickey, 2021, ACS Macro Letters on p. 1216-1222
Differential ligand-selective control of opposing enzymatic activities within a bifunctional c-di-GMP enzyme
Dayna Patterson, Myrrh Perez Ruiz, Myrrh Perez Ruiz, Hyerin Yoon, Johnnie Walker, Jean-Paul Armache, Neela Yennawar, Emily Weinert, 2021, Proceedings of the National Academy of Sciences of the United States of America on p. 9
Maize unstable factor for orange1 is essential for endosperm development and carbohydrate accumulation
Debamalya Chatterjee, Kameron Wittmeyer, Tzuu Fen Lee, Jin Cui, Neela H. Yennawar, Hemant P. Yennawar, Blake C. Meyers, Surinder Chopra, 2021, Plant Physiology on p. 1932-1950
Small Glycols Discover Cryptic Pockets on Proteins for Fragment-Based Approaches
Harsh Bansia, Pranjal Mahanta, Neela H. Yennawar, Suryanarayanarao Ramakumar, 2021, Journal of Chemical Information and Modeling on p. 1322-1333
Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB
Olga A. Esakova, Tyler Grove, Neela H. Yennawar, Arthur Arcinas, Bo Wang, Wang, Carsten Krebs, Steven Almo, Squire Booker, 2021, Nature on p. 566-570
Most-Cited Papers
Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma
Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale, Diana D. Shi, Januka Khanal, Abhishek A. Chakraborty, Kristopher A. Sarosiek, Kimberly J. Briggs, Alissa K. Robbins, Tomasz Sewastianik, Sarah J. Shareef, Benjamin A. Olenchock, Seth J. Parker, Kensuke Tateishi, Jessica B. Spinelli, Mirazul Islam, Marcia C. Haigis, Ryan E. Looper, Keith L. Ligon, Bradley E. Bernstein, Ruben D. Carrasco, Daniel P. Cahill, John M. Asara, Christian M. Metallo, Neela H. Yennawar, Matthew G. Vander Heiden, William G. Kaelin, 2018, Cell on p. 101-116.e25
Inhibition of pancreatic lipase by black tea theaflavins: Comparative enzymology and in silico modeling studies
Shannon L. Glisan, Kimberly A. Grove, Neela H. Yennawar, Joshua D. Lambert, 2017, Food Chemistry on p. 296-300
Precise Manipulation and Patterning of Protein Crystals for Macromolecular Crystallography Using Surface Acoustic Waves
Feng Guo, Weijie Zhou, Peng Li, Zhangming Mao, Neela H. Yennawar, Jarrod B. French, Tony Jun Huang, 2015, Small on p. 2733-2737
Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate
Sang Ah Kim, Jiang Zhu, Neela Yennawar, Priit Eek, Song Tan, 2020, Molecular Cell on p. 903-914.e4
Molecular crowding favors reactivity of a human ribozyme under physiological ionic conditions
Christopher A. Strulson, Neela H. Yennawar, Robert P. Rambo, Philip C. Bevilacqua, 2013, Biochemistry on p. 8187-8197
Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases
Bigna Wörsdörfer, Mahesh Lingaraju, Neela H. Yennawar, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, Maria Eirini Pandelia, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 18874-18879
The GlcN6P cofactor plays multiple catalytic roles in the glmS ribozyme
Jamie L. Bingaman, Sixue Zhang, David R. Stevens, Neela H. Yennawar, Sharon Hammes-Schiffer, Philip C. Bevilacqua, 2017, Nature Chemical Biology on p. 439-445
Enhanced performance and stability in DNA-perovskite heterostructure-based solar cells
Yuchen Hou, Kai Wang, Dong Yang, Yuanyuan Jiang, Neela Yennawar, Ke Wang, Mohan Sanghadasa, Congcong Wu, Shashank Priya, 2019, ACS Energy Letters on p. 2646-2655
Cooperative RNA Folding under Cellular Conditions Arises from Both Tertiary Structure Stabilization and Secondary Structure Destabilization
Kathleen A. Leamy, Neela H. Yennawar, Philip C. Bevilacqua, 2017, Biochemistry on p. 3422-3433
Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA
Michael DiMarzio, Brigida Rusconi, Neela H. Yennawar, Mark Eppinger, Andrew D. Patterson, Edward G. Dudley, 2017, PLoS One
News Articles Featuring Neela Yennawar
May 31, 2023
A protein mines, sorts rare earths better than humans, paving way for green tech
Rare earth elements, like neodymium and dysprosium, are a critical component to almost all modern technologies, from smartphones to hard drives, but they are notoriously hard to separate from the Earth’s crust and from one another.
Full Article
Oct 18, 2022
Newly engineered protein could be used to develop adaptation-proof COVID vaccine
A vaccine design approach that could protect against new variants of SARS-CoV-2 — the virus that causes COVID-19 — but also potentially protects against other coronaviruses is one step closer to reality as a result of research at Penn State College of Medicine.
Full Article
Jan 13, 2022
Core facilities director brings more than technical advice to research
Directors of the core facilities at Penn State’s Huck Institutes of the Life Sciences are more than expert technicians — they are also researchers in their own right. And though their unique contributions are not always consistently recognized within the broader community, faculty researchers who work in the core facilities are well aware of these unsung heroes' many impressive insights.
Full Article
Aug 20, 2019
Penn State Chemistry Alum Recognized with Young Scientists Award
Kathleen Leamy has been awarded the 2019 Gordon Hammes Scholar Award, based on a 2018 article she co-authored with the Huck Institutes' Neela Yennawar and Phillip Bevilacqua.
Full Article