Neela Yennawar

Director, X-Ray Crystallography and Automated Biological Calorimetry Core Facilities

Neela Yennawar

Research Summary

Biological calorimetry, protein characterization, molecular modeling, X-ray crystallography, and small-angle X-ray scattering.

Huck Affiliations

Publication Tags

Proteins Enzymes Rna X Ray Crystallography Oxidation Reduction Glutamic Acid Alpha Hydroxyglutarate Glutaminase Transaminases Transfer Rna Biosynthesis Catalytic Rna X Rays Choloylglycine Hydrolase Crystallography Tea Homeostasis Rna Folding Dna In Vitro Techniques Molecules Nucleotides Temperature Peptides Glycols

Most Recent Papers

Small Glycols Discover Cryptic Pockets on Proteins for Fragment-Based Approaches

Harsh Bansia, Pranjal Mahanta, Neela H. Yennawar, Suryanarayanarao Ramakumar, 2021, Journal of Chemical Information and Modeling on p. 1322-1333

Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate

Sang Ah Kim, Jiang Zhu, Neela Yennawar, Priit Eek, Song Tan, 2020, Molecular Cell on p. 903-914.e4

Single-nucleotide control of tRNA folding cooperativity under near-cellular conditions

Kathleen A. Leamy, Ryota Yamagami, Neela H. Yennawar, Philip C. Bevilacqua, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 23075-23082

Enhanced performance and stability in DNA-perovskite heterostructure-based solar cells

Yuchen Hou, Kai Wang, Dong Yang, Yuanyuan Jiang, Neela Yennawar, Ke Wang, Mohan Sanghadasa, Congcong Wu, Shashank Priya, 2019, ACS Energy Letters on p. 2646-2655

An unexpected species determined by X-ray crystallography that may represent an intermediate in the reaction catalyzed by quinolinate synthase

Olga A. Esakova, Alexey Silakov, Tyler L. Grove, Douglas M. Warui, Neela H. Yennawar, Squire J. Booker, 2019, Journal of the American Chemical Society on p. 14142-14151

Physicochemical interactions with (-)-epigallocatechin-3-gallate drive structural modification of celiac-associated peptide α<sub>2</sub>-gliadin (57-89) at physiological conditions

Charlene B. Van Buiten, Neela H. Yennawar, Carlos N. Pacheco, Emmanuel Hatzakis, Ryan J. Elias, 2019, Food and Function on p. 2997-3007

Structures of Class Id Ribonucleotide Reductase Catalytic Subunits Reveal a Minimal Architecture for Deoxynucleotide Biosynthesis

Hannah R. Rose, Ailiena O. Maggiolo, Molly J. McBride, Gavin M. Palowitch, Maria Eirini Pandelia, Katherine M. Davis, Neela H. Yennawar, Amie K. Boal, 2019, Biochemistry on p. 1845-1860

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale, Diana D. Shi, Januka Khanal, Abhishek A. Chakraborty, Kristopher A. Sarosiek, Kimberly J. Briggs, Alissa K. Robbins, Tomasz Sewastianik, Sarah J. Shareef, Benjamin A. Olenchock, Seth J. Parker, Kensuke Tateishi, Jessica B. Spinelli, Mirazul Islam, Marcia C. Haigis, Ryan E. Looper, Keith L. Ligon, Bradley E. Bernstein, Ruben D. Carrasco, Daniel P. Cahill, John M. Asara, Christian M. Metallo, Neela H. Yennawar, Matthew G. Vander Heiden, William G. Kaelin, 2018, Cell on p. 101-116.e25

Molecular Mechanism for Folding Cooperativity of Functional RNAs in Living Organisms

Kathleen A. Leamy, Neela Yennawar, Philip C. Bevilacqua, 2018, Biochemistry on p. 2994-3002

Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA

Michael DiMarzio, Brigida Rusconi, Neela Yennawar, Mark Eppinger, Andrew David Patterson, Edward G. Dudley, 2017, PLoS One

Most-Cited Papers

Structural basis for methyl transfer by a radical SAM enzyme

Amie Kathleen Boal, Tyler L. Grove, Monica I. McLaughlin, Neela Yennawar, Squire J. Booker, Amy C. Rosenzweig, 2011, Science on p. 1089-1092

Structural basis for entropy-driven cellulose binding by a type-A cellulose-binding module (CBM) and bacterial expansin

Nikolaos Georgelis, Neela H. Yennawar, Daniel J. Cosgrove, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. 14830-14835

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale, Diana D. Shi, Januka Khanal, Abhishek A. Chakraborty, Kristopher A. Sarosiek, Kimberly J. Briggs, Alissa K. Robbins, Tomasz Sewastianik, Sarah J. Shareef, Benjamin A. Olenchock, Seth J. Parker, Kensuke Tateishi, Jessica B. Spinelli, Mirazul Islam, Marcia C. Haigis, Ryan E. Looper, Keith L. Ligon, Bradley E. Bernstein, Ruben D. Carrasco, Daniel P. Cahill, John M. Asara, Christian M. Metallo, Neela H. Yennawar, Matthew G. Vander Heiden, William G. Kaelin, 2018, Cell on p. 101-116.e25

Inhibition of pancreatic lipase by black tea theaflavins

Shannon L. Glisan, Kimberly A. Grove, Neela H. Yennawar, Joshua D. Lambert, 2017, Food Chemistry on p. 296-300

Precise Manipulation and Patterning of Protein Crystals for Macromolecular Crystallography Using Surface Acoustic Waves

Feng Guo, Weijie Zhou, Peng Li, Zhangming Mao, Neela H. Yennawar, Jarrod B. French, Tony Jun Huang, 2015, Small on p. 2733-2737

Molecular crowding favors reactivity of a human ribozyme under physiological ionic conditions

Christopher A. Strulson, Neela H. Yennawar, Robert P. Rambo, Philip C. Bevilacqua, 2013, Biochemistry on p. 8187-8197

"The GlcN6P cofactor plays multiple catalytic roles in the glmS ribozyme"

Jamie Bingaman, Sixue Zhang, David Stevens, Neela Yennawar, Sharon Hammes-Schiffer, Philip Bevilacqua, 2017, Nature Chemical Biology on p. 439-445

Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases

Bigna Wörsdörfer, Mahesh Lingaraju, Neela H. Yennawar, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, Maria Eirini Pandelia, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 18874-18879

Cooperative RNA Folding under Cellular Conditions Arises from Both Tertiary Structure Stabilization and Secondary Structure Destabilization

Kathleen A. Leamy, Neela H. Yennawar, Philip C. Bevilacqua, 2017, Biochemistry on p. 3422-3433

X-ray crystal structure and small-angle X-ray scattering of sheep liver sorbitol dehydrogenase

Hemant Yennawar, Magda Mller, Richard Gillilan, Neela Yennawar, 2011, Acta Crystallographica Section D: Structural Biology on p. 440-446