Neela Yennawar
Director, X-Ray Crystallography and Automated Biological Calorimetry Core Facilities
- 0088 Althouse Lab
University Park, PA 16802 - nhy1@psu.edu
- 814-863-9387
Research Summary
Biological calorimetry, protein characterization, molecular modeling, X-ray crystallography, and small-angle X-ray scattering.
Huck Institutes Affiliations
Publication Tags
Enzymes Rna Proteins Tea Catalytic Rna Lipase Theaflavin Transfer Rna Disulfides Temperature X Rays Catalytic Domain Oxidoreductases Choloylglycine Hydrolase Biosynthesis Amino Acids Hot Temperature Ions Rna, Transfer, Phe X Ray Crystallography Rna Folding Oxidation Reduction Calorimetry In Vitro Techniques Black TeaMost Recent Papers
Structures of Class Id Ribonucleotide Reductase Catalytic Subunits Reveal a Minimal Architecture for Deoxynucleotide Biosynthesis
Hannah R. Rose, Ailiena O. Maggiolo, Molly J. McBride, Gavin M. Palowitch, Maria Eirini Pandelia, Katherine M. Davis, Neela Yennawar, Amie Kathleen Boal, 2019, Biochemistry on p. 1845-1860
Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma
Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale, Diana D. Shi, Januka Khanal, Abhishek A. Chakraborty, Kristopher A. Sarosiek, Kimberly J. Briggs, Alissa K. Robbins, Tomasz Sewastianik, Sarah J. Shareef, Benjamin A. Olenchock, Seth J. Parker, Kensuke Tateishi, Jessica B. Spinelli, Mirazul Islam, Marcia C. Haigis, Ryan E. Looper, Keith L. Ligon, Bradley E. Bernstein, Ruben D. Carrasco, Daniel P. Cahill, John M. Asara, Christian M. Metallo, Neela Yennawar, Matthew G. Vander Heiden, William G. Kaelin, 2018, Cell on p. 101-116.e25
Molecular Mechanism for Folding Cooperativity of Functional RNAs in Living Organisms
Kathleen A. Leamy, Neela Yennawar, Philip C. Bevilacqua, 2018, Biochemistry on p. 2994-3002
Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA
Michael DiMarzio, Brigida Rusconi, Neela Yennawar, Mark Eppinger, Andrew David Patterson, Edward G. Dudley, 2017, PLoS One
Cooperative RNA Folding under Cellular Conditions Arises from Both Tertiary Structure Stabilization and Secondary Structure Destabilization
Kathleen A. Leamy, Neela Yennawar, Philip C. Bevilacqua, 2017, Biochemistry on p. 3422-3433
The GlcN6P cofactor plays multiple catalytic roles in the glmS ribozyme
Jamie L. Bingaman, Sixue Zhang, David R. Stevens, Neela Yennawar, Sharon Hammes-Schiffer, Philip C. Bevilacqua, 2017, Nature Chemical Biology on p. 439-445
Inhibition of pancreatic lipase by black tea theaflavins
Shannon L. Glisan, Kimberly A. Grove, Neela Yennawar, Joshua D. Lambert, 2017, Food Chemistry on p. 296-300
Structure of Quinolinate Synthase from Pyrococcus horikoshii in the Presence of Its Product, Quinolinic Acid
Olga A. Esakova, Alexey Silakov, Tyler L. Grove, Allison H. Saunders, Martin I. McLaughlin, Neela Yennawar, Squire J. Booker, 2016, Journal of the American Chemical Society on p. 7224-7227
Structural and Biochemical Characterizations of Methanoredoxin from Methanosarcina acetivorans, a Glutaredoxin-Like Enzyme with Coenzyme M-Dependent Protein Disulfide Reductase Activity
Deepa Yenugudhati, Divya Prakash, Adepu K. Kumar, R. Siva Sai Kumar, Neela Yennawar, Hemant P. Yennawar, James Gregory Ferry, 2016, Biochemistry on p. 313-321
A High-Throughput Biological Calorimetry Core
Neela H. Yennawar, Julia A. Fecko, Scott A. Showalter, Philip C. Bevilacqua, 2016, Methods in Enzymology on p. 435-460
High-Impact Papers
Structural basis for methyl transfer by a radical SAM enzyme
Amie Kathleen Boal, Tyler L. Grove, Monica I. McLaughlin, Neela Yennawar, Squire J. Booker, Amy C. Rosenzweig, 2011, Science on p. 1089-1092
Structural basis for entropy-driven cellulose binding by a type-A cellulose-binding module (CBM) and bacterial expansin
Nikolaos Georgelis, Neela Yennawar, Daniel J. Cosgrove, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. 14830-14835
Molecular crowding favors reactivity of a human ribozyme under physiological ionic conditions
Christopher A. Strulson, Neela Yennawar, Robert P. Rambo, Philip C. Bevilacqua, 2013, Biochemistry on p. 8187-8197
Precise Manipulation and Patterning of Protein Crystals for Macromolecular Crystallography Using Surface Acoustic Waves
Feng Guo, Weijie Zhou, Peng Li, Zhangming Mao, Neela Yennawar, Jarrod B. French, Tony Jun Huang, 2015, Small on p. 2733-2737
The GlcN6P cofactor plays multiple catalytic roles in the glmS ribozyme
Jamie L. Bingaman, Sixue Zhang, David R. Stevens, Neela Yennawar, Sharon Hammes-Schiffer, Philip C. Bevilacqua, 2017, Nature Chemical Biology on p. 439-445
Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases
Bigna Wörsdörfer, Mahesh Lingaraju, Neela Yennawar, Amie Kathleen Boal, Carsten Krebs, Joseph M. Bollinger, Jr., Maria Eirini Pandelia, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 18874-18879
Cooperative RNA Folding under Cellular Conditions Arises from Both Tertiary Structure Stabilization and Secondary Structure Destabilization
Kathleen A. Leamy, Neela Yennawar, Philip C. Bevilacqua, 2017, Biochemistry on p. 3422-3433
Inhibition of pancreatic lipase by black tea theaflavins
Shannon L. Glisan, Kimberly A. Grove, Neela Yennawar, Joshua D. Lambert, 2017, Food Chemistry on p. 296-300
Structural and biochemical characterization of a ferredoxin
Adepu K. Kumar, R. Siva Sai Kumar, Neela Yennawar, Hemant P. Yennawar, James Gregory Ferry, 2015, Biochemistry on p. 3122-3128
X-ray crystal structure and small-angle X-ray scattering of sheep liver sorbitol dehydrogenase
Hemant P. Yennawar, Magda Mller, Richard Gillilan, Neela Yennawar, 2011, Acta Crystallographica Section D: Biological Crystallography on p. 440-446