Neela Yennawar

Director, X-Ray Crystallography and Automated Biological Calorimetry Core Facilities; Research Professor

Neela Yennawar

Research Summary

Biological calorimetry, protein characterization, molecular modeling, X-ray crystallography, and small-angle X-ray scattering.

Huck Affiliations

Publication Tags

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Proteins Rna Enzymes Protein Catalytic Rna Perovskite Genes Choloylglycine Hydrolase Crystallography Crystallization Dna X Ray Crystallography Heme Transfer Rna Glycols Tea Glutaminase Sonication Vaccines Oxidation Reduction Solar Cells Carbohydrates Theaflavin Thermodynamics Weight

Most Recent Publications

Adaptation-Proof SARS-CoV-2 Vaccine Design

Yashavantha L. Vishweshwaraiah, Brianna Hnath, Brendan Rackley, Jian Wang, Abhinay Gontu, Morgan Chandler, Kirill A. Afonin, Suresh V. Kuchipudi, Neil Christensen, Neela H. Yennawar, Nikolay V. Dokholyan, 2022, Advanced Functional Materials

The Metabolome Weakens RNA Thermodynamic Stability and Strengthens RNA Chemical Stability

Jacob P. Sieg, Lauren N. McKinley, Melanie J. Huot, Neela H. Yennawar, Philip C. Bevilacqua, 2022, Biochemistry on p. 2579-2591

Enteroviral 2C protein is an RNA-stimulated ATPase and uses a two-step mechanism for binding to RNA and ATP

Calvin Yeager, Griffin Carter, David W. Gohara, Neela H. Yennawar, Eric J. Enemark, Jamie J. Arnold, Craig E. Cameron, 2022, Nucleic Acids Research on p. 11775-11798

Bio-inspired strategies for next-generation perovskite solar mobile power sources

Jungjin Yoon, Yuchen Hou, Abbey Marie Knoepfel, Dong Yang, Tao Ye, Luyao Zheng, Neela Yennawar, Mohan Sanghadasa, Shashank Priya, Kai Wang, 2021, Chemical Society Reviews on p. 12915-12984

Heme-Edge Residues Modulate Signal Transduction within a Bifunctional Homo-Dimeric Sensor Protein

Dayna Patterson, Yilin Liu, Sayan Das, Neela H. Yennawar, Jean-Paul Armache, James Kincaid, Emily E. Weinert, 2021, Biochemistry on p. 3801-3812

Cocrystalline Polymer Films Exhibiting Second-Order Nonlinear Optical Properties

Yifan Xu, Rui Zu, Neela H. Yennawar, Venkatraman Gopalan, Robert J. Hickey, 2021, ACS Macro Letters on p. 1216-1222

Differential ligand-selective control of opposing enzymatic activities within a bifunctional c-di-GMP enzyme

Dayna Patterson, Myrrh Perez Ruiz, Myrrh Perez Ruiz, Hyerin Yoon, Johnnie Walker, Jean-Paul Armache, Neela Yennawar, Emily Weinert, 2021, Proceedings of the National Academy of Sciences of the United States of America on p. 9

Maize unstable factor for orange1 is essential for endosperm development and carbohydrate accumulation

Debamalya Chatterjee, Kameron Wittmeyer, Tzuu Fen Lee, Jin Cui, Neela H. Yennawar, Hemant P. Yennawar, Blake C. Meyers, Surinder Chopra, 2021, Plant Physiology on p. 1932-1950

Small Glycols Discover Cryptic Pockets on Proteins for Fragment-Based Approaches

Harsh Bansia, Pranjal Mahanta, Neela H. Yennawar, Suryanarayanarao Ramakumar, 2021, Journal of Chemical Information and Modeling on p. 1322-1333

Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB

Olga A. Esakova, Tyler Grove, Neela H. Yennawar, Arthur Arcinas, Bo Wang, Wang, Carsten Krebs, Steven Almo, Squire Booker, 2021, Nature on p. 566-570

Most-Cited Papers

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale, Diana D. Shi, Januka Khanal, Abhishek A. Chakraborty, Kristopher A. Sarosiek, Kimberly J. Briggs, Alissa K. Robbins, Tomasz Sewastianik, Sarah J. Shareef, Benjamin A. Olenchock, Seth J. Parker, Kensuke Tateishi, Jessica B. Spinelli, Mirazul Islam, Marcia C. Haigis, Ryan E. Looper, Keith L. Ligon, Bradley E. Bernstein, Ruben D. Carrasco, Daniel P. Cahill, John M. Asara, Christian M. Metallo, Neela H. Yennawar, Matthew G. Vander Heiden, William G. Kaelin, 2018, Cell on p. 101-116.e25

Inhibition of pancreatic lipase by black tea theaflavins: Comparative enzymology and in silico modeling studies

Shannon L. Glisan, Kimberly A. Grove, Neela H. Yennawar, Joshua D. Lambert, 2017, Food Chemistry on p. 296-300

Precise Manipulation and Patterning of Protein Crystals for Macromolecular Crystallography Using Surface Acoustic Waves

Feng Guo, Weijie Zhou, Peng Li, Zhangming Mao, Neela H. Yennawar, Jarrod B. French, Tony Jun Huang, 2015, Small on p. 2733-2737

Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate

Sang Ah Kim, Jiang Zhu, Neela Yennawar, Priit Eek, Song Tan, 2020, Molecular Cell on p. 903-914.e4

Molecular crowding favors reactivity of a human ribozyme under physiological ionic conditions

Christopher A. Strulson, Neela H. Yennawar, Robert P. Rambo, Philip C. Bevilacqua, 2013, Biochemistry on p. 8187-8197

Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases

Bigna Wörsdörfer, Mahesh Lingaraju, Neela H. Yennawar, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, Maria Eirini Pandelia, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 18874-18879

The GlcN6P cofactor plays multiple catalytic roles in the glmS ribozyme

Jamie L. Bingaman, Sixue Zhang, David R. Stevens, Neela H. Yennawar, Sharon Hammes-Schiffer, Philip C. Bevilacqua, 2017, Nature Chemical Biology on p. 439-445

Enhanced performance and stability in DNA-perovskite heterostructure-based solar cells

Yuchen Hou, Kai Wang, Dong Yang, Yuanyuan Jiang, Neela Yennawar, Ke Wang, Mohan Sanghadasa, Congcong Wu, Shashank Priya, 2019, ACS Energy Letters on p. 2646-2655

Cooperative RNA Folding under Cellular Conditions Arises from Both Tertiary Structure Stabilization and Secondary Structure Destabilization

Kathleen A. Leamy, Neela H. Yennawar, Philip C. Bevilacqua, 2017, Biochemistry on p. 3422-3433

Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA

Michael DiMarzio, Brigida Rusconi, Neela H. Yennawar, Mark Eppinger, Andrew D. Patterson, Edward G. Dudley, 2017, PLoS One

News Articles Featuring Neela Yennawar

May 31, 2023

A protein mines, sorts rare earths better than humans, paving way for green tech

Rare earth elements, like neodymium and dysprosium, are a critical component to almost all modern technologies, from smartphones to hard drives, but they are notoriously hard to separate from the Earth’s crust and from one another.

Full Article

Oct 18, 2022

Newly engineered protein could be used to develop adaptation-proof COVID vaccine

A vaccine design approach that could protect against new variants of SARS-CoV-2 — the virus that causes COVID-19 — but also potentially protects against other coronaviruses is one step closer to reality as a result of research at Penn State College of Medicine.

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Jan 13, 2022

Core facilities director brings more than technical advice to research

Directors of the core facilities at Penn State’s Huck Institutes of the Life Sciences are more than expert technicians — they are also researchers in their own right. And though their unique contributions are not always consistently recognized within the broader community, faculty researchers who work in the core facilities are well aware of these unsung heroes' many impressive insights.

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Aug 20, 2019

Penn State Chemistry Alum Recognized with Young Scientists Award

Kathleen Leamy has been awarded the 2019 Gordon Hammes Scholar Award, based on a 2018 article she co-authored with the Huck Institutes' Neela Yennawar and Phillip Bevilacqua.

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