Ibrahim Moustafa
Assistant Research Professor of Biochemistry and Molecular Biology
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W231 Millennium Science Complex
University Park, PA - ria2@psu.edu
- 814-865-5733
Research Summary
Process and analyze cryo-EM data to generate high-resolution 3D reconstructions using established software packages.
Huck Affiliations
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Publication Tags
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Rna Replicase Nucleotides Poliovirus Lipids Nucleotide Viruses Proteins Viral Rna Rna Enzymes Molecular Dynamics Phosphorylation Vaccines Antiviral Agents Triphosphoric Acid Rna Viruses Conformations Computer Simulation Mutation Coulomb Interactions Lipid Assembly Zika Virus Virus Assembly Structural DynamicsMost Recent Publications
Induced copy-back RNA synthesis as a therapeutic mechanism against RNA viruses
Ibrahim Moustafa, bioRxiv
Interfering with nucleotide excision by the coronavirus 3<sup>'</sup>-to-5<sup>'</sup> exoribonuclease
Rukesh Chinthapatla, Mohamad Sotoudegan, Pankaj Srivastava, Thomas K. Anderson, Ibrahim M. Moustafa, Kellan T. Passow, Samantha A. Kennelly, Ramkumar Moorthy, David Dulin, Joy Y. Feng, Daniel A. Harki, Robert N. Kirchdoerfer, Craig E. Cameron, Jamie J. Arnold, 2023, Nucleic Acids Research on p. 315-336
Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model.
D Patel, Ibrahim Moustafa, A Minns, D Sims, C Field, A Kerr, T Heinly, E Luley, R Rossi, C Bator, I Mostafa, Susan Hafenstein, S Lindner, Troy Sutton, 2022, bioRxiv : the preprint server for biology
Interfering with nucleotide excision by the coronavirus 3`-to-5` exoribonuclease
Ibrahim Moustafa, 2022, bioRxiv
Induced intra- and intermolecular template switching as a therapeutic mechanism against RNA viruses
Richard Janissen, Andrew Woodman, Djoshkun Shengjuler, Thomas Vallet, Kuo Ming Lee, Louis Kuijpers, Ibrahim M. Moustafa, Fiona Fitzgerald, Peng Nien Huang, Angela L. Perkins, Daniel A. Harki, Jamie J. Arnold, Belén Solano, Shin Ru Shih, Marco Vignuzzi, Craig E. Cameron, Nynke H. Dekker, 2021, Molecular Cell on p. 4467-4480.e7
Identification of a pocket factor that is critical to Zika virus assembly
Nadia M. DiNunno, Daniel J. Goetschius, Anoop Narayanan, Sydney A. Majowicz, Ibrahim Moustafa, Carol M. Bator, Susan L. Hafenstein, Joyce Jose, 2020, Nature Communications
Rational Control of Poliovirus RNA-Dependent RNA Polymerase Fidelity by Modulating Motif-D Loop Conformational Dynamics
Jingjing Shi, Jacob M. Perryman, Xiaorong Yang, Xinran Liu, Derek M. Musser, Alyson K. Boehr, Ibrahim M. Moustafa, Jamie J. Arnold, Craig E. Cameron, David D. Boehr, 2019, Biochemistry on p. 3735-3743
Molecular dynamics simulations suggest changes in electrostatic interactions as a potential mechanism through which serine phosphorylation inhibits DNA polymerase β activity
Dirar Homouz, Kwee Hong Joyce-Tan, Mohd ShahirShamsir, Ibrahim Moustafa, Haitham T. Idriss, 2018, Journal of Molecular Graphics and Modelling on p. 236-241
Molecular dynamics simulations suggest changes in electrostatic interactions as a potential mechanism through which serine phosphorylation inhibits DNA polymerase β activity.
D Homouz, K Joyce-Tan, M ShahirShamsir, Ibrahim Moustafa, H Idriss, 2018, Journal of molecular graphics & modelling on p. 236-241
Molecular dynamics simulations suggest changes in electrostatic interactions as a potential mechanism through which serine phosphorylation inhibits DNA polymerase $\beta$ activity
Dirar Homouz, Kwee Joyce-Tan, Mohd ShahirShamsir, Ibrahim Moustafa, Haitham Idriss, 2018, Journal of Molecular Graphics and Modelling on p. 236--241
Most-Cited Papers
Sequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in Mosquitoes
Greta A. Van Slyke, Jamie J. Arnold, Alex J. Lugo, Sara B. Griesemer, Ibrahim M. Moustafa, Laura D. Kramer, Craig E. Cameron, Alexander T. Ciota, 2015, PLoS Pathogens
Vaccine-derived mutation in motif D of poliovirus RNA-dependent RNA polymerase lowers nucleotide incorporation fidelity
Xinran Liu, Xiaorong Yang, Cheri A. Lee, Ibrahim M. Moustafa, Eric D. Smidansky, David Lum, Jamie J. Arnold, Craig E. Cameron, David D. Boehr, 2013, Journal of Biological Chemistry on p. 32753-32765
Structural dynamics as a contributor to error-prone replication by an RNA-dependent RNA polymerase
Ibrahim M. Moustafa, Victoria K. Korboukh, Jamie J. Arnold, Eric D. Smidansky, Laura L. Marcotte, David W. Gohara, Xiaorong Yang, María Antonieta Saánchez-Farraán, David Filman, Janna K. Maranas, David D. Boehr, James M. Hogle, Coray M. Colina, Craig E. Cameron, 2014, Journal of Biological Chemistry on p. 36229-36248
Identification of a pocket factor that is critical to Zika virus assembly
Nadia M. DiNunno, Daniel J. Goetschius, Anoop Narayanan, Sydney A. Majowicz, Ibrahim Moustafa, Carol M. Bator, Susan L. Hafenstein, Joyce Jose, 2020, Nature Communications
Fidelity of Nucleotide Incorporation by the RNA-Dependent RNA Polymerase from Poliovirus
C. E. Cameron, I. M. Moustafa, J. J. Arnold, 2016, DNA REPLICATION ACROSS TAXA on p. 293--323
The RNA-Binding Site of Poliovirus 3C Protein Doubles as a Phosphoinositide-Binding Domain
Djoshkun Shengjuler, Yan Mei Chan, Simou Sun, Ibrahim M. Moustafa, Zhen Lu Li, David W. Gohara, Matthias Buck, Paul S. Cremer, David D. Boehr, Craig E. Cameron, 2017, Structure with Folding & design on p. 1875-1886.e7
Triphosphate reorientation of the incoming nucleotide as a fidelity checkpoint in viral RNA-dependent RNA Polymerases
Xiaorong Yang, Xinran Liu, Derek M. Musser, Ibrahim M. Moustafa, Jamie J. Arnold, Craig E. Cameron, David D. Boehr, 2017, Journal of Biological Chemistry on p. 3810-3826
Rational Control of Poliovirus RNA-Dependent RNA Polymerase Fidelity by Modulating Motif-D Loop Conformational Dynamics
Jingjing Shi, Jacob M. Perryman, Xiaorong Yang, Xinran Liu, Derek M. Musser, Alyson K. Boehr, Ibrahim M. Moustafa, Jamie J. Arnold, Craig E. Cameron, David D. Boehr, 2019, Biochemistry on p. 3735-3743
Conformational ensemble of the poliovirus 3CD precursor observed by MD simulations and confirmed by SAXS: A strategy to expand the viral proteome?
Ibrahim M. Moustafa, David W. Gohara, Akira Uchida, Neela Yennawar, Craig E. Cameron, 2015, Viruses on p. 5962-5986
Long-Range Communication between Different Functional Sites in the Picornaviral 3C Protein
Yan M. Chan, Ibrahim M. Moustafa, Jamie J. Arnold, Craig E. Cameron, David D. Boehr, 2016, Structure with Folding & design on p. 509-517