Philip Bevilacqua
Co-Director, Center for RNA Molecular Biology; Distinguished Professor of Chemistry and of Biochemistry and Molecular Biology

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242 Chemistry
University Park, PA - He/Him/His
- pcb5@psu.edu
- 814-863-3812
Research Summary
RNA folding in vivo and genome-wide; RNA regulation of gene expression; Ribozyme Mechanism; roles RNA may have played in the emergence of life on early earth
Huck Affiliations
- Bioinformatics and Genomics
- Plant Biology
- Center for RNA Molecular Biology
- Molecular, Cellular, and Integrative Biosciences
- Plant Institute
Links
Publication Tags
Rna Catalytic Rna Catalysis Genome Ions Nucleotides Polymerization Bioreactors Climate Emulsions Ion Arabidopsis Polyamines Phase Separation Proteins Liquids Nucleic Acids Temperature Free Energy Spermine Rna Folding Viruses Prediction Liposomes GuanineMost Recent Papers
Experimental demonstration and pan-structurome prediction of climate-associated riboSNitches in Arabidopsis
Ángel Ferrero-Serrano, Megan M. Sylvia, Peter C. Forstmeier, Andrew J. Olson, Doreen Ware, Philip C. Bevilacqua, Sarah M. Assmann, 2022, Genome Biology
Phase-specific RNA accumulation and duplex thermodynamics in multiphase coacervate models for membraneless organelles
S Choi, Philip Bevilacqua, C Keating, 2022, Nature Commun.
RNA multimerization as an organizing force for liquid–liquid phase separation
Philip C. Bevilacqua, Allison M. Williams, Hong Li Chou, Sarah M. Assmann, 2022, RNA on p. 16-26
RNA sequence and structure control assembly and function of RNA condensates
Raghav R. Poudyal, Jacob P. Sieg, Bede Portz, Christine D. Keating, Philip C. Bevilacqua, 2021, RNA on p. 1589-1601
Investigation of the pK<sub>a</sub> of the nucleophilic O2' of the hairpin ribozyme
Andrew J. Veenis, Pengfei Li, Alexander V. Soudackov, Sharon Hammes-Schiffer, Philip C. Bevilacqua, 2021, Journal of Physical Chemistry B on p. 11869-11883
Long Tracts of Guanines Drive Aggregation of RNA G-Quadruplexes in the Presence of Spermine
Allison M. Williams, Raghav R. Poudyal, Philip C. Bevilacqua, 2021, Biochemistry on p. 2715-2726
Functional Roles of Chelated Magnesium Ions in RNA Folding and Function
Ryota Yamagami, Jacob P. Sieg, Philip C. Bevilacqua, 2021, Biochemistry on p. 2374-2386
Efficient construction of long DNA duplexes with internal non-Watson-Crick motifs and modifications
Xiaofeng Zheng, Philip C. Bevilacqua, 2021, Nucleic Acids Research
Measuring the activity and structure of functional RNAs inside compartments formed by liquid-liquid phase separation
Raghav R. Poudyal, McCauley O. Meyer, Philip C. Bevilacqua, 2021, on p. 307-327
Inverse RNA folding workflow to design and test ribozymes that include pseudoknots
Mohammad Kayedkhordeh, Ryota Yamagami, Philip C. Bevilacqua, David H. Mathews, 2021, on p. 113-143
Most-Cited Papers
In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features
Yiliang Ding, Yin Tang, Chun Kit Kwok, Yu Zhang, Philip C. Bevilacqua, Sarah M. Assmann, 2014, Nature on p. 696-700
RNA catalysis through compartmentalization
Christopher A. Strulson, Rosalynn C. Molden, Christine D. Keating, Philip C. Bevilacqua, 2012, Nature Chemistry on p. 941-946
Bioreactor droplets from liposome-stabilized all-aqueous emulsions
Daniel C. Dewey, Christopher A. Strulson, David N. Cacace, Philip C. Bevilacqua, Christine D. Keating, 2014, Nature Communications
Genome-Wide Analysis of RNA Secondary Structure
Philip C. Bevilacqua, Laura E. Ritchey, Zhao Su, Sarah M. Assmann, 2016, Annual Review of Genetics on p. 235-266
The RNA structurome
Chun Kit Kwok, Yin Tang, Sarah M. Assmann, Philip C. Bevilacqua, 2015, Trends in Biochemical Sciences on p. 221-232
Template-directed RNA polymerization and enhanced ribozyme catalysis inside membraneless compartments formed by coacervates
Raghav R. Poudyal, Rebecca M. Guth-Metzler, Andrew J. Veenis, Erica A. Frankel, Christine D. Keating, Philip C. Bevilacqua, 2019, Nature Communications on p. 490
Determination of in vivo RNA structure in low-abundance transcripts
Chun Kit Kwok, Yiliang Ding, Yin Tang, Sarah M. Assmann, Philip C. Bevilacqua, 2013, Nature Communications
Polyamine/Nucleotide Coacervates Provide Strong Compartmentalization of Mg<sup>2+</sup>, Nucleotides, and RNA
Erica A. Frankel, Philip C. Bevilacqua, Christine D. Keating, 2016, Langmuir on p. 2041-2049
Physical Principles and Extant Biology Reveal Roles for RNA Containing Membraneless Compartments in Origins of Life Chemistry
Raghav Poudyal, Fatma Cakmak, Christine Keating, Philip Bevilacqua, 2018, Biochemistry on p. 2509-2519
Quantum mechanical/molecular mechanical free energy simulations of the self-cleavage reaction in the hepatitis delta virus ribozyme
Abir Ganguly, Pallavi Thaplyal, Edina Rosta, Philip C. Bevilacqua, Sharon Hammes-Schiffer, 2014, Journal of the American Chemical Society on p. 1483-1496
News Articles Featuring Philip Bevilacqua
Aug 20, 2019
Penn State Chemistry Alum Recognized with Young Scientists Award
Kathleen Leamy has been awarded the 2019 Gordon Hammes Scholar Award, based on a 2018 article she co-authored with the Huck Institutes' Neela Yennawar and Phillip Bevilacqua.
Full Article
Apr 19, 2019
NIH Trainees Juan Cerda and Catherine Douds Receive NSF-GRFP Honorable Mentions
Juan Cerda and Catherine Douds, both members of NIH-sponsored training programs overseen by the Huck Institutes, were recognized for their promising research ideas.
Full Article