Philip Bevilacqua

Co-Director, Center for RNA Molecular Biology; Distinguished Professor of Chemistry and Biochemistry & Molecular Biology

Philip Bevilacqua

Research Summary

Roles of RNA-binding proteins in plant physiology. Plant ribonomics. Identification and characterization of functional RNAs in plants.

Huck Institutes Affiliations

Publication Tags

Rna Catalytic Rna Catalysis Ions Base Pairing Amino Acids Thermionic Emission Emulsions Bioreactors Stabilization Transfer Rna Proteins Temperature Viruses Genome Nucleotides Metals Acids Magnesium Molecules Hepatitis Delta Virus Liposomes Hot Temperature Lewis Acids Crystal Structure

Most Recent Papers

Cellular conditions of weakly chelated magnesium ions strongly promote RNA stability and catalysis

Ryota Yamagami, Jamie L. Bingaman, Erica A. Frankel, Philip C. Bevilacqua, 2018, Nature Communications

Cellular Small Molecules Contribute to Twister Ribozyme Catalysis

Kyle J. Messina, Philip C. Bevilacqua, 2018, Journal of the American Chemical Society on p. 10578-10582


David C. Tack, Yin Tang, Laura E. Ritchey, Sarah M. Assmann, Philip C. Bevilacqua, 2018, Methods on p. 12-15

Molecular Mechanism for Folding Cooperativity of Functional RNAs in Living Organisms

Kathleen A. Leamy, Neela H. Yennawar, Philip C. Bevilacqua, 2018, Biochemistry on p. 2994-3002

Elucidation of Catalytic Strategies of Small Nucleolytic Ribozymes from Comparative Analysis of Active Sites

Daniel D. Seith, Jamie L. Bingaman, Andrew J. Veenis, Aileen C. Button, Philip C. Bevilacqua, 2018, ACS Catalysis on p. 314-327

Modeling RNA secondary structure folding ensembles using SHAPE mapping data

Aleksandar Spasic, Sarah M. Assmann, Philip C. Bevilacqua, David H. Mathews, 2018, Nucleic Acids Research on p. 314-323

Glyoxals as in vivo RNA structural probes of guanine base-pairing

David Mitchell, Laura E. Ritchey, Hongmarn Park, Paul Babitzke, Sarah M. Assmann, Philip C. Bevilacqua, 2018, RNA on p. 114-124

Activation of the glmS Ribozyme Nucleophile via Overdetermined Hydrogen Bonding

Jamie L. Bingaman, Inanllely Y. Gonzalez, Bo Wang, Philip C. Bevilacqua, 2017, Biochemistry on p. 4313-4317


Laura E. Ritchey, Zhao Su, Yin Tang, David C. Tack, Sarah M. Assmann, Philip C. Bevilacqua, 2017, Nucleic Acids Research on p. e135

Cooperative RNA Folding under Cellular Conditions Arises from Both Tertiary Structure Stabilization and Secondary Structure Destabilization

Kathleen A. Leamy, Neela H. Yennawar, Philip C. Bevilacqua, 2017, Biochemistry on p. 3422-3433

High-Impact Papers

In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features

Yiliang Ding, Yin Tang, Chun Kit Kwok, Yu Zhang, Philip C. Bevilacqua, Sarah M. Assmann, 2014, Nature on p. 696-700

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

Bart R. Anderson, Hiromi Muramatsu, Subba R. Nallagatla, Philip C. Bevilacqua, Lauren H. Sansing, Drew Weissman, Katalin Karikó, 2010, Nucleic Acids Research on p. 5884-5892

RNA catalysis through compartmentalization

Christopher A. Strulson, Rosalynn C. Molden, Christine D. Keating, Philip C. Bevilacqua, 2012, Nature Chemistry on p. 941-946

A 1.9 Å crystal structure of the HDV ribozyme precleavage suggests both lewis acid and general acid mechanisms contribute to phosphodiester cleavage

Jui H. Chen, Rieko Yajima, Durga M. Chadalavada, Elaine Chase, Philip C. Bevilacqua, Barbara L. Golden, 2010, Biochemistry on p. 6508-6518

Nucleoside modifications modulate activation of the protein kinase PKR in an RNA structure-specific manner

Subba Rao Nallagatla, Philip C. Bevilacqua, 2008, RNA on p. 1201-1213

Bioreactor droplets from liposome-stabilized all-aqueous emulsions

Daniel C. Dewey, Christopher A. Strulson, David N. Cacace, Philip C. Bevilacqua, Christine D. Keating, 2014, Nature Communications

Determination of in vivo RNA structure in low-abundance transcripts

Chun Kit Kwok, Yiliang Ding, Yin Tang, Sarah M. Assmann, Philip C. Bevilacqua, 2013, Nature Communications

Charged nucleobases and their potential for RNA catalysis

Jennifer L. Wilcox, Amarpreet K. Ahluwalia, Philip C. Bevilacqua, 2011, Accounts of Chemical Research on p. 1270-1279

Metal binding motif in the active site of the HDV ribozyme binds divalent and monovalent ions

Narayanan Veeraraghavan, Abir Ganguly, Jui Hui Chen, Philip C. Bevilacqua, Sharon Hammes-Schiffer, Barbara L. Golden, 2011, Biochemistry on p. 2672-2682

RNA Dimerization Promotes PKR Dimerization and Activation

Laurie A. Heinicke, C. Jason Wong, Jeffrey Lary, Subba Rao Nallagatla, Amy Diegelman-Parente, Xiaofeng Zheng, James L. Cole, Philip C. Bevilacqua, 2009, Journal of Molecular Biology on p. 319-338