Philip Bevilacqua
Co-Director, Center for RNA Molecular Biology; Distinguished Professor of Chemistry and of Biochemistry and Molecular Biology

-
242 Chemistry
University Park, PA - He/Him/His
- pcb5@psu.edu
- 814-863-3812
Research Summary
RNA folding in vivo and genome-wide; RNA regulation of gene expression; Ribozyme Mechanism; roles RNA may have played in the emergence of life on early earth
Huck Graduate Students
Huck Affiliations
- Bioinformatics and Genomics
- Plant Biology
- Center for RNA Molecular Biology
- Molecular, Cellular, and Integrative Biosciences
- Plant Institute
Links
Publication Tags
These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.
Rna Nucleotides Genome Catalysis Polymerization Bioreactors Rna Structure Climate Emulsions Dna Arabidopsis Polyamines Catalytic Rna Nucleic Acids Genes Temperature Thermodynamics Prediction Liposomes Nucleic Acid Chemistry Transcriptome Messenger Rna Chlorides Heat Shock ResponseMost Recent Publications
Transcriptome-wide probing reveals RNA thermometers that regulate translation of glycerol permease genes in Bacillus subtilis
Elizabeth A. Jolley, Helen Yakhnin, David Tack, Paul Babitzke, Philip C. Bevilacqua, 2023, RNA on p. 1365-1378
MeltR software provides facile determination of nucleic acid thermodynamics
Jacob P. Sieg, Sebastian J. Arteaga, Brent M. Znosko, Philip C. Bevilacqua, 2023, Biophysical Reports
Rock, scissors, paper: How RNA structure informs function
Sarah M. Assmann, Hong Li Chou, Philip C. Bevilacqua, 2023, Plant Cell on p. 1671-1707
Structure-seq of tRNAs and other short RNAs in droplets and in vivo
McCauley O. Meyer, Saehyun Choi, Christine D. Keating, Philip C. Bevilacqua, Ryota Yamagami, 2023,
The Metabolome Weakens RNA Thermodynamic Stability and Strengthens RNA Chemical Stability
Jacob P. Sieg, Lauren N. McKinley, Melanie J. Huot, Neela H. Yennawar, Philip C. Bevilacqua, 2022, Biochemistry on p. 2579-2591
Regulatory Mechanisms through RNA Conformational Switching and Dynamics
Philip C. Bevilacqua, Blanton S. Tolbert, 2022, Journal of Molecular Biology
Biological solution conditions and flanking sequence modulate LLPS of RNA G-quadruplex structures
Allison M. Williams, Taylor M. Dickson, Claudia A. Lagoa-Miguel, Philip C. Bevilacqua, 2022, RNA on p. 1197-1209
Upstream Flanking Sequence Assists Folding of an RNA Thermometer
Elizabeth Jolley, Kathryn Bormes, Philip C. Bevilacqua, 2022, Journal of Molecular Biology on p. 13
Genome-wide analysis of the in vivo tRNA structurome reveals RNA structural and modification dynamics under heat stress
Ryota Yamagami, Jacob P. Sieg, Sarah M. Assmann, Philip C. Bevilacqua, 2022, Proceedings of the National Academy of Sciences of the United States of America on p. e2201237119
Experimental demonstration and pan-structurome prediction of climate-associated riboSNitches in Arabidopsis
Angel Ferrero-Serrano, Megan M. Sylvia, Peter C. Forstmeier, Andrew J. Olson, Doreen Ware, Philip C. Bevilacqua, Sarah M. Assmann, 2022, Genome Biology
Most-Cited Papers
In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features
Yiliang Ding, Yin Tang, Chun Kit Kwok, Yu Zhang, Philip C. Bevilacqua, Sarah M. Assmann, 2014, Nature on p. 696-700
Bioreactor droplets from liposome-stabilized all-aqueous emulsions
Daniel C. Dewey, Christopher A. Strulson, David N. Cacace, Philip C. Bevilacqua, Christine D. Keating, 2014, Nature Communications
Genome-Wide Analysis of RNA Secondary Structure
Philip C. Bevilacqua, Laura Ritchey, Zhao Su, Sarah M. Assmann, 2016, Annual Review of Genetics on p. 235--266
Template-directed RNA polymerization and enhanced ribozyme catalysis inside membraneless compartments formed by coacervates
Raghav R. Poudyal, Rebecca M. Guth-Metzler, Andrew J. Veenis, Erica A. Frankel, Christine D. Keating, Philip C. Bevilacqua, 2019, Nature Communications on p. 490
The RNA structurome: Transcriptome-wide structure probing with next-generation sequencing
Chun Kit Kwok, Yin Tang, Sarah M. Assmann, Philip C. Bevilacqua, 2015, Trends in Biochemical Sciences on p. 221-232
Physical Principles and Extant Biology Reveal Roles for RNA-Containing Membraneless Compartments in Origins of Life Chemistry
Raghav Poudyal, Fatma Cakmak, Christine Keating, Philip Bevilacqua, 2018, Biochemistry on p. 2509-2519
Polyamine/Nucleotide Coacervates Provide Strong Compartmentalization of Mg<sup>2+</sup>, Nucleotides, and RNA
Erica A. Frankel, Philip C. Bevilacqua, Christine D. Keating, 2016, Langmuir on p. 2041-2049
Determination of in vivo RNA structure in low-abundance transcripts
Chun Kit Kwok, Yiliang Ding, Yin Tang, Sarah M. Assmann, Philip C. Bevilacqua, 2013, Nature Communications
Experimental approaches for measuring pK<sub>a</sub>'s in RNA and DNA
Pallavi Thaplyal, Philip C. Bevilacqua, 2014, Methods in enzymology on p. 189-219
Genome-wide profiling of in vivo RNA structure at single-nucleotide resolution using structure-seq
Yiliang Ding, Chun Kit Kwok, Yin Tang, Philip C. Bevilacqua, Sarah M. Assmann, 2015, Nature Protocols on p. 1050-1066
News Articles Featuring Philip Bevilacqua
Jul 06, 2023
Penn State chemist Stephen Benkovic named Atherton Professor
Stephen Benkovic, Evan Pugh Professor and Holder of the Eberly Family Chair in Chemistry at Penn State, has been honored by Penn State with the title of Atherton Professor.
Full Article
Apr 20, 2023
Grad Students in Huck Labs Win Awards for Innovative Research
Two graduate students—one in the Huck's Neuroscience program and the other in the Eberly College of Science's BMMB program—have been named recipients of an award available to those working in Biochemistry and Molecular Biology labs. Both PIs are also part of the Huck.
Full Article
Apr 17, 2023
Structured Nucleic Acids Day, Robert Simpson and Sons Lecture set for April 18
A half-day symposium on structured (noncanonical) nucleic acids will be held on Tuesday, April 18, in Foster Auditorium, Paterno Library, Penn State University Park.
Full Article
Feb 23, 2023
Nobel Prize-winning Penn State alumnus Paul Berg dies
Penn State alumnus Paul Berg, who received the 1980 Nobel Prize in chemistry, died Feb. 15 at his home in Stanford, California, surrounded by loved ones. He was 96.
Full Article
Aug 31, 2022
Boal recieves Early Career Award from Society of Biological Inorganic Chemistry
Amie Boal, professor of chemistry and of biochemistry and molecular biology, has been named a recipient of the 2022 Early Career Award from the International Society for Biological Inorganic Chemistry (SBIC), an organization dedicated to advancing research and promoting understanding of biological inorganic chemistry within academia, industry, and the general public
Full Article
Jun 13, 2022
Climate-associated genetic switches found in plants
Genetic variants that can act as switches directing structural changes in the RNA molecules that code for proteins in plants have been experimentally validated in plants for the first time. The changes to RNA structure can affect the molecule’s stability, how it interacts with other molecules, and how efficiently it can be translated into protein — all of which can impact its function and the traits of the plant.
Full Article
Aug 20, 2019
Penn State Chemistry Alum Recognized with Young Scientists Award
Kathleen Leamy has been awarded the 2019 Gordon Hammes Scholar Award, based on a 2018 article she co-authored with the Huck Institutes' Neela Yennawar and Phillip Bevilacqua.
Full Article
Apr 19, 2019
NIH Trainees Juan Cerda and Catherine Douds Receive NSF-GRFP Honorable Mentions
Juan Cerda and Catherine Douds, both members of NIH-sponsored training programs overseen by the Huck Institutes, were recognized for their promising research ideas.
Full Article