Philip Bevilacqua

Co-Director, Center for RNA Molecular Biology; Distinguished Professor of Chemistry and of Biochemistry and Molecular Biology

Philip Bevilacqua

Research Summary

RNA folding in vivo and genome-wide; RNA regulation of gene expression; Ribozyme Mechanism; roles RNA may have played in the emergence of life on early earth

Huck Affiliations

Links

Publication Tags

Rna Catalysis Catalytic Rna Nucleotides Ions Polymerization Enzymes Dna Chlorides Magnesium Viruses Compartments Bioreactors Emulsions Nucleic Acids Diphosphates Prebiotics Polyanions Metals Polycations Messenger Rna Free Energy Molecular Dynamics Liposomes Templates

Most Recent Papers

Efficient construction of long DNA duplexes with internal non-Watson-Crick motifs and modifications

Xiaofeng Zheng, Philip C. Bevilacqua, 2021, Nucleic Acids Research

Prebiotically-relevant low polyion multivalency can improve functionality of membraneless compartments

Fatma Pir Cakmak, Saehyun Choi, McCauley C.O. Meyer, Philip C. Bevilacqua, Christine D. Keating, 2020, Nature Communications

Csra-mediated translational activation of ymda expression in escherichia coli

Andrew Renda, Stephanie Poly, Ying Jung Lai, Archana Pannuri, Helen Yakhnin, Anastasia H. Potts, Philip C. Bevilacqua, Tony Romeo, Paul Babitzke, 2020, mBio on p. 1-12

MRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity

Joseph A. Waldron, David C. Tack, Laura E. Ritchey, Sarah L. Gillen, Ania Wilczynska, Ernest Turro, Philip C. Bevilacqua, Sarah M. Assmann, Martin Bushell, John Le Quesne, 2019, Genome Biology on p. 300

Small molecule rescue and glycosidic conformational analysis of the twister ribozyme

Kyle J. Messina, Ryszard Kierzek, Matthew A. Tracey, Philip C. Bevilacqua, 2019, Biochemistry on p. 4857-4868

Template-directed RNA polymerization and enhanced ribozyme catalysis inside membraneless compartments formed by coacervates

Raghav R. Poudyal, Rebecca M. Guth-Metzler, Andrew J. Veenis, Erica A. Frankel, Christine Dolan Keating, Philip C. Bevilacqua, 2019, Nature Communications on p. 490

Single-nucleotide control of tRNA folding cooperativity under near-cellular conditions

Kathleen A. Leamy, Ryota Yamagami, Neela H. Yennawar, Philip C. Bevilacqua, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 23075-23082

Cellular Concentrations of Nucleotide Diphosphate-Chelated Magnesium Ions Accelerate Catalysis by RNA and DNA Enzymes

Ryota Yamagami, Ruochuan Huang, Philip C. Bevilacqua, 2019, Biochemistry on p. 3971-3979

Polyanion-Assisted Ribozyme Catalysis Inside Complex Coacervates

Raghav R. Poudyal, Christine D. Keating, Philip C. Bevilacqua, 2019, ACS Chemical Biology on p. 1243-1248

Design of highly active double-pseudoknotted ribozymes

Ryota Yamagami, Mohammad Kayedkhordeh, David H. Mathews, Philip C. Bevilacqua, 2019, Nucleic Acids Research on p. 29-42

Most-Cited Papers

In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features

Yiliang Ding, Yin Tang, Chun Kit Kwok, Yu Zhang, Philip C. Bevilacqua, Sarah Mary Assmann, 2014, Nature on p. 696-700

RNA catalysis through compartmentalization

Christopher A. Strulson, Rosalynn C. Molden, Christine D. Keating, Philip C. Bevilacqua, 2012, Nature Chemistry on p. 941-946

Bioreactor droplets from liposome-stabilized all-aqueous emulsions

Daniel C. Dewey, Christopher A. Strulson, David N. Cacace, Philip C. Bevilacqua, Christine D. Keating, 2014, Nature Communications

Determination of in vivo RNA structure in low-abundance transcripts

Chun Kit Kwok, Yiliang Ding, Yin Tang, Sarah M. Assmann, Philip C. Bevilacqua, 2013, Nature Communications

Charged nucleobases and their potential for RNA catalysis

Jennifer L. Wilcox, Amarpreet K. Ahluwalia, Philip C. Bevilacqua, 2011, Accounts of Chemical Research on p. 1270-1279

Polyamine/Nucleotide Coacervates Provide Strong Compartmentalization of Mg<sup>2+</sup>, Nucleotides, and RNA

Erica A. Frankel, Philip C. Bevilacqua, Christine D. Keating, 2016, Langmuir on p. 2041-2049

The nuclear magnetic resonance of CCCC RNA reveals a right-handed helix, and revised parameters for AMBER force field torsions improve structural predictions from molecular dynamics

Jason D. Tubbs, David E. Condon, Scott D. Kennedy, Melanie Hauser, Philip C. Bevilacqua, Douglas H. Turner, 2013, Biochemistry on p. 996-1010

Quantum mechanical/molecular mechanical free energy simulations of the self-cleavage reaction in the hepatitis delta virus ribozyme

Abir Ganguly, Pallavi Thaplyal, Edina Rosta, Philip C. Bevilacqua, Sharon Hammes-Schiffer, 2014, Journal of the American Chemical Society on p. 1483-1496

Metal binding motif in the active site of the HDV ribozyme binds divalent and monovalent ions

Narayanan Veeraraghavan, Abir Ganguly, Jui Hui Chen, Philip C. Bevilacqua, Sharon Hammes-Schiffer, Barbara L. Golden, 2011, Biochemistry on p. 2672-2682

Template-directed RNA polymerization and enhanced ribozyme catalysis inside membraneless compartments formed by coacervates

Raghav R. Poudyal, Rebecca M. Guth-Metzler, Andrew J. Veenis, Erica A. Frankel, Christine Dolan Keating, Philip C. Bevilacqua, 2019, Nature Communications on p. 490