Philip Bevilacqua

Co-Director, Center for RNA Molecular Biology; Distinguished Professor of Chemistry and of Biochemistry and Molecular Biology

Philip Bevilacqua

Research Summary

RNA folding in vivo and genome-wide; RNA regulation of gene expression; Ribozyme Mechanism; roles RNA may have played in the emergence of life on early earth

Huck Affiliations

Links

Publication Tags

Rna Catalysis Catalytic Rna Nucleotides Polymerization Enzymes Dna Chlorides Magnesium Bioreactors Emulsions Compartments Nucleic Acids Diphosphates Genome Liquids Rna Folding Proteins Templates Ions Liposomes Polyamines Phase Separation Prebiotics Polycations

Most Recent Papers

Measuring the activity and structure of functional RNAs inside compartments formed by liquid-liquid phase separation

Raghav R. Poudyal, McCauley O. Meyer, Philip C. Bevilacqua, 2021, on p. 307-327

Inverse RNA folding workflow to design and test ribozymes that include pseudoknots

Mohammad Kayedkhordeh, Ryota Yamagami, Philip C. Bevilacqua, David H. Mathews, 2021, on p. 113-143

Efficient construction of long DNA duplexes with internal non-Watson-Crick motifs and modifications

Xiaofeng Zheng, Philip C. Bevilacqua, 2021, Nucleic Acids Research

Prebiotically-relevant low polyion multivalency can improve functionality of membraneless compartments

Fatma Pir Cakmak, Saehyun Choi, McCauley C.O. Meyer, Philip C. Bevilacqua, Christine D. Keating, 2020, Nature Communications

Amino acid specific nonenzymatic montmorillonite-promoted RNA polymerization

T. Namani, S. Snyder, J. Eagan, Philip Bevilacqua, C. Wesdemiotis, N. Sahai, 2020, ChemSystemsChem

Small molecule rescue and glycosidic conformational analysis of the twister ribozyme

Kyle J. Messina, Ryszard Kierzek, Matthew A. Tracey, Philip C. Bevilacqua, 2019, Biochemistry on p. 4857-4868

Template-directed RNA polymerization and enhanced ribozyme catalysis inside membraneless compartments formed by coacervates

Raghav R. Poudyal, Rebecca M. Guth-Metzler, Andrew J. Veenis, Erica A. Frankel, Christine Dolan Keating, Philip C. Bevilacqua, 2019, Nature Communications on p. 490

Probing RNA structure in vivo

David Mitchell, Sarah M. Assmann, Philip C. Bevilacqua, 2019, Current Opinion in Structural Biology on p. 151-158

Single-nucleotide control of tRNA folding cooperativity under near-cellular conditions

Kathleen A. Leamy, Ryota Yamagami, Neela H. Yennawar, Philip C. Bevilacqua, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 23075-23082

Cellular Concentrations of Nucleotide Diphosphate-Chelated Magnesium Ions Accelerate Catalysis by RNA and DNA Enzymes

Ryota Yamagami, Ruochuan Huang, Philip C. Bevilacqua, 2019, Biochemistry on p. 3971-3979

Most-Cited Papers

In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features

Yiliang Ding, Yin Tang, Chun Kit Kwok, Yu Zhang, Philip C. Bevilacqua, Sarah Mary Assmann, 2014, Nature on p. 696-700

RNA catalysis through compartmentalization

Christopher A. Strulson, Rosalynn C. Molden, Christine D. Keating, Philip C. Bevilacqua, 2012, Nature Chemistry on p. 941-946

Bioreactor droplets from liposome-stabilized all-aqueous emulsions

Daniel C. Dewey, Christopher A. Strulson, David N. Cacace, Philip C. Bevilacqua, Christine D. Keating, 2014, Nature Communications

Genome-Wide Analysis of RNA Secondary Structure

Philip C. Bevilacqua, Laura E. Ritchey, Zhao Su, Sarah M. Assmann, 2016, Annual Review of Genetics on p. 235-266

Regulation of innate immunity through RNA structure and the protein kinase PKR

Subba Rao Nallagatla, Rebecca Toroney, Philip C. Bevilacqua, 2011, Current Opinion in Structural Biology on p. 119-127

The RNA structurome

Chun Kit Kwok, Yin Tang, Sarah M. Assmann, Philip C. Bevilacqua, 2015, Trends in Biochemical Sciences on p. 221-232

Determination of in vivo RNA structure in low-abundance transcripts

Chun Kit Kwok, Yiliang Ding, Yin Tang, Sarah M. Assmann, Philip C. Bevilacqua, 2013, Nature Communications

Template-directed RNA polymerization and enhanced ribozyme catalysis inside membraneless compartments formed by coacervates

Raghav R. Poudyal, Rebecca M. Guth-Metzler, Andrew J. Veenis, Erica A. Frankel, Christine Dolan Keating, Philip C. Bevilacqua, 2019, Nature Communications on p. 490

Charged nucleobases and their potential for RNA catalysis

Jennifer L. Wilcox, Amarpreet K. Ahluwalia, Philip C. Bevilacqua, 2011, Accounts of Chemical Research on p. 1270-1279

Polyamine/Nucleotide Coacervates Provide Strong Compartmentalization of Mg<sup>2+</sup>, Nucleotides, and RNA

Erica A. Frankel, Philip C. Bevilacqua, Christine D. Keating, 2016, Langmuir on p. 2041-2049