Philip Bevilacqua
Co-Director, Center for RNA Molecular Biology; Distinguished Professor of Chemistry and of Biochemistry and Molecular Biology

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242 Chemistry
University Park, PA - He/Him/His
- pcb5@psu.edu
- 814-863-3812
Research Summary
RNA folding in vivo and genome-wide; RNA regulation of gene expression; Ribozyme Mechanism; roles RNA may have played in the emergence of life on early earth
Huck Graduate Students
Huck Affiliations
- Bioinformatics and Genomics
- Plant Biology
- Center for RNA Molecular Biology
- Molecular, Cellular, and Integrative Biosciences
- Plant Institute
Links
Publication Tags
Rna Nucleotides Genome Catalysis Thermodynamics Polymerization Catalytic Rna Bioreactors Rna Structure Climate Emulsions Dna Polyamines Arabidopsis Phase Separation Nucleic Acids Temperature Genes Liposomes Prediction Nucleic Acid Protein Ground State Molecular Dynamics TranscriptomeMost Recent Publications
Experimental demonstration and pan-structurome prediction of climate-associated riboSNitches in Arabidopsis
Ángel Ferrero-Serrano, Megan M. Sylvia, Peter C. Forstmeier, Andrew J. Olson, Doreen Ware, Philip C. Bevilacqua, Sarah M. Assmann, 2022, Genome Biology
The Metabolome Weakens RNA Thermodynamic Stability and Strengthens RNA Chemical Stability
Jacob P. Sieg, Lauren N. McKinley, Melanie J. Huot, Neela H. Yennawar, Philip C. Bevilacqua, 2022, Biochemistry on p. 2579-2591
Regulatory Mechanisms through RNA Conformational Switching and Dynamics
Philip C. Bevilacqua, Blanton S. Tolbert, 2022, Journal of Molecular Biology
Upstream Flanking Sequence Assists Folding of an RNA Thermometer
Elizabeth A. Jolley, Kathryn M. Bormes, Philip C. Bevilacqua, 2022, Journal of Molecular Biology
Biological solution conditions and flanking sequence modulate LLPS of RNA G-quadruplex structures
Allison M. Williams, Taylor M. Dickson, Claudia A. Lagoa-Miguel, Philip C. Bevilacqua, 2022, RNA on p. 1197-1209
Genome-wide analysis of the in vivo tRNA structurome reveals RNA structural and modification dynamics under heat stress
Ryota Yamagami, Jacob P. Sieg, Sarah M. Assmann, Philip C. Bevilacqua, 2022, Proceedings of the National Academy of Sciences of the United States of America
Phase-specific RNA accumulation and duplex thermodynamics in multiphase coacervate models for membraneless organelles
Saehyun Choi, McCauley C.O. Meyer, Philip C. Bevilacqua, Christine D. Keating, 2022, Nature Chemistry
RNA multimerization as an organizing force for liquid–liquid phase separation
Philip C. Bevilacqua, Allison M. Williams, Hong Li Chou, Sarah M. Assmann, 2022, RNA on p. 16-26
RNA sequence and structure control assembly and function of RNA condensates
Raghav R. Poudyal, Jacob P. Sieg, Bede Portz, Christine D. Keating, Philip C. Bevilacqua, 2021, RNA on p. 1589-1601
Investigation of the pK<sub>a</sub> of the nucleophilic O2' of the hairpin ribozyme
Andrew J. Veenis, Pengfei Li, Alexander V. Soudackov, Sharon Hammes-Schiffer, Philip C. Bevilacqua, 2021, Journal of Physical Chemistry B on p. 11869-11883
Most-Cited Papers
In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features
Yiliang Ding, Yin Tang, Chun Kit Kwok, Yu Zhang, Philip C. Bevilacqua, Sarah M. Assmann, 2014, Nature on p. 696-700
Bioreactor droplets from liposome-stabilized all-aqueous emulsions
Daniel C. Dewey, Christopher A. Strulson, David N. Cacace, Philip C. Bevilacqua, Christine D. Keating, 2014, Nature Communications
Genome-Wide Analysis of RNA Secondary Structure
Philip C. Bevilacqua, Laura Ritchey, Zhao Su, Sarah M. Assmann, 2016, Annual Review of Genetics on p. 235--266
Template-directed RNA polymerization and enhanced ribozyme catalysis inside membraneless compartments formed by coacervates
Raghav R. Poudyal, Rebecca M. Guth-Metzler, Andrew J. Veenis, Erica A. Frankel, Christine D. Keating, Philip C. Bevilacqua, 2019, Nature Communications on p. 490
The RNA structurome: Transcriptome-wide structure probing with next-generation sequencing
Chun Kit Kwok, Yin Tang, Sarah M. Assmann, Philip C. Bevilacqua, 2015, Trends in Biochemical Sciences on p. 221-232
Determination of in vivo RNA structure in low-abundance transcripts
Chun Kit Kwok, Yiliang Ding, Yin Tang, Sarah M. Assmann, Philip C. Bevilacqua, 2013, Nature Communications
Physical Principles and Extant Biology Reveal Roles for RNA-Containing Membraneless Compartments in Origins of Life Chemistry
Raghav Poudyal, Fatma Cakmak, Christine Keating, Philip Bevilacqua, 2018, Biochemistry on p. 2509-2519
Polyamine/Nucleotide Coacervates Provide Strong Compartmentalization of Mg<sup>2+</sup>, Nucleotides, and RNA
Erica A. Frankel, Philip C. Bevilacqua, Christine D. Keating, 2016, Langmuir on p. 2041-2049
Experimental approaches for measuring pK<sub>a</sub>'s in RNA and DNA
Pallavi Thaplyal, Philip C. Bevilacqua, 2014, Methods in enzymology on p. 189-219
Genome-wide profiling of in vivo RNA structure at single-nucleotide resolution using structure-seq
Yiliang Ding, Chun Kit Kwok, Yin Tang, Philip C. Bevilacqua, Sarah M. Assmann, 2015, Nature Protocols on p. 1050-1066
News Articles Featuring Philip Bevilacqua
Aug 31, 2022
Boal recieves Early Career Award from Society of Biological Inorganic Chemistry
Amie Boal, professor of chemistry and of biochemistry and molecular biology, has been named a recipient of the 2022 Early Career Award from the International Society for Biological Inorganic Chemistry (SBIC), an organization dedicated to advancing research and promoting understanding of biological inorganic chemistry within academia, industry, and the general public
Full Article
Jun 13, 2022
Climate-associated genetic switches found in plants
Genetic variants that can act as switches directing structural changes in the RNA molecules that code for proteins in plants have been experimentally validated in plants for the first time. The changes to RNA structure can affect the molecule’s stability, how it interacts with other molecules, and how efficiently it can be translated into protein — all of which can impact its function and the traits of the plant.
Full Article
Aug 20, 2019
Penn State Chemistry Alum Recognized with Young Scientists Award
Kathleen Leamy has been awarded the 2019 Gordon Hammes Scholar Award, based on a 2018 article she co-authored with the Huck Institutes' Neela Yennawar and Phillip Bevilacqua.
Full Article
Apr 19, 2019
NIH Trainees Juan Cerda and Catherine Douds Receive NSF-GRFP Honorable Mentions
Juan Cerda and Catherine Douds, both members of NIH-sponsored training programs overseen by the Huck Institutes, were recognized for their promising research ideas.
Full Article