Philip Bevilacqua

Co-Director, Center for RNA Molecular Biology; Distinguished Professor of Chemistry and of Biochemistry and Molecular Biology

Philip Bevilacqua

Research Summary

RNA folding in vivo and genome-wide; RNA regulation of gene expression; Ribozyme Mechanism; roles RNA may have played in the emergence of life on early earth

Huck Graduate Students

Huck Affiliations


Publication Tags

Rna Nucleotides Genome Catalysis Catalytic Rna Polymerization Bioreactors Rna Structure Climate Emulsions Arabidopsis Phase Separation Polyamines Thermodynamics Temperature Nucleic Acids Protein Liposomes Ion Guanine Prediction Spermine Genes Transcriptome Ions

Most Recent Publications

Ángel Ferrero-Serrano, Megan M. Sylvia, Peter C. Forstmeier, Andrew J. Olson, Doreen Ware, Philip C. Bevilacqua, Sarah M. Assmann, 2022, Genome Biology

Regulatory Mechanisms through RNA Conformational Switching and Dynamics

Philip C. Bevilacqua, Blanton S. Tolbert, 2022, Journal of Molecular Biology

Biological solution conditions and flanking sequence modulate LLPS of RNA G-quadruplex structures

Allison M. Williams, Taylor M. Dickson, Claudia A. Lagoa-Miguel, Philip C. Bevilacqua, 2022, RNA on p. 1197-1209

Genome-wide analysis of the in vivo tRNA structurome reveals RNA structural and modification dynamics under heat stress

Ryota Yamagami, Jacob P. Sieg, Sarah M. Assmann, Philip C. Bevilacqua, 2022, Proceedings of the National Academy of Sciences of the United States of America

Philip C. Bevilacqua, Allison M. Williams, Hong Li Chou, Sarah M. Assmann, 2022, RNA on p. 16-26

Saehyun Choi, McCauley C.O. Meyer, Philip C. Bevilacqua, Christine D. Keating, 2022, Nature Chemistry

RNA sequence and structure control assembly and function of RNA condensates

Raghav R. Poudyal, Jacob P. Sieg, Bede Portz, Christine D. Keating, Philip C. Bevilacqua, 2021, RNA on p. 1589-1601

Investigation of the pK<sub>a</sub> of the nucleophilic O2' of the hairpin ribozyme

Andrew J. Veenis, Pengfei Li, Alexander V. Soudackov, Sharon Hammes-Schiffer, Philip C. Bevilacqua, 2021, Journal of Physical Chemistry B on p. 11869-11883

Allison M. Williams, Raghav R. Poudyal, Philip C. Bevilacqua, 2021, Biochemistry on p. 2715-2726

Ryota Yamagami, Jacob P. Sieg, Philip C. Bevilacqua, 2021, Biochemistry on p. 2374-2386

Most-Cited Papers

In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features

Yiliang Ding, Yin Tang, Chun Kit Kwok, Yu Zhang, Philip C. Bevilacqua, Sarah M. Assmann, 2014, Nature on p. 696-700

RNA catalysis through compartmentalization

Christopher A. Strulson, Rosalynn C. Molden, Christine D. Keating, Philip C. Bevilacqua, 2012, Nature Chemistry on p. 941-946

Daniel C. Dewey, Christopher A. Strulson, David N. Cacace, Philip C. Bevilacqua, Christine D. Keating, 2014, Nature Communications

Genome-Wide Analysis of RNA Secondary Structure

Philip C. Bevilacqua, Laura E. Ritchey, Zhao Su, Sarah M. Assmann, 2016, Annual Review of Genetics on p. 235-266

The RNA structurome

Chun Kit Kwok, Yin Tang, Sarah M. Assmann, Philip C. Bevilacqua, 2015, Trends in Biochemical Sciences on p. 221-232

Raghav R. Poudyal, Rebecca M. Guth-Metzler, Andrew J. Veenis, Erica A. Frankel, Christine D. Keating, Philip C. Bevilacqua, 2019, Nature Communications on p. 490

Chun Kit Kwok, Yiliang Ding, Yin Tang, Sarah M. Assmann, Philip C. Bevilacqua, 2013, Nature Communications

Raghav Poudyal, Fatma Cakmak, Christine Keating, Philip Bevilacqua, 2018, Biochemistry on p. 2509-2519

Polyamine/Nucleotide Coacervates Provide Strong Compartmentalization of Mg<sup>2+</sup>, Nucleotides, and RNA

Erica A. Frankel, Philip C. Bevilacqua, Christine D. Keating, 2016, Langmuir on p. 2041-2049

Genome-wide profiling of in vivo RNA structure at single-nucleotide resolution using structure-seq

Yiliang Ding, Chun Kit Kwok, Yin Tang, Philip C. Bevilacqua, Sarah M. Assmann, 2015, Nature Protocols on p. 1050-1066

News Articles Featuring Philip Bevilacqua

Boal recieves Early Career Award from Society of Biological Inorganic Chemistry

Amie Boal, professor of chemistry and of biochemistry and molecular biology, has been named a recipient of the 2022 Early Career Award from the International Society for Biological Inorganic Chemistry (SBIC), an organization dedicated to advancing research and promoting understanding of biological inorganic chemistry within academia, industry, and the general public

Climate-associated genetic switches found in plants

Genetic variants that can act as switches directing structural changes in the RNA molecules that code for proteins in plants have been experimentally validated in plants for the first time. The changes to RNA structure can affect the molecule’s stability, how it interacts with other molecules, and how efficiently it can be translated into protein — all of which can impact its function and the traits of the plant.

Penn State Chemistry Alum Recognized with Young Scientists Award

Kathleen Leamy has been awarded the 2019 Gordon Hammes Scholar Award, based on a 2018 article she co-authored with the Huck Institutes' Neela Yennawar and Phillip Bevilacqua.

NIH Trainees Juan Cerda and Catherine Douds Receive NSF-GRFP Honorable Mentions

Juan Cerda and Catherine Douds, both members of NIH-sponsored training programs overseen by the Huck Institutes, were recognized for their promising research ideas.