Song Tan

Director of the Center for Eukaryotic Gene Regulation; Professor of Biochemistry and Molecular Biology

Song Tan

Research Summary

Structural biology of eukaryotic gene regulation.

Huck Affiliations

Links

Most Recent Publications

Cheng Xu, Holly Kleinschmidt, Jianyu Yang, Erik M. Leith, Jenna Johnson, Song Tan, Shaun Mahony, Lu Bai, 2024, Molecular Cell on p. 2838-2855.e10

Alexander S. Baier, Nathan Gioacchini, Priit Eek, Erik M. Leith, Song Tan, Craig L. Peterson, 2024, eLife

A Baier, N Gioacchini, P Eek, Song Tan, C Peterson, 2023, Research square

Benjamin T. Donovan, Hengye Chen, Priit Eek, Zhiyuan Meng, Caroline Jipa, Song Tan, Lu Bai, Michael G. Poirier, 2023, Molecular Cell on p. 1251-1263.e6

Un Seng Chio, Othman Rechiche, Alysia R. Bryll, Jiang Zhu, Erik M. Leith, Jessica L. Feldman, Craig L. Peterson, Song Tan, Jean Paul Armache, 2023, Science advances

Kevin E.W. Namitz, Song Tan, Michael S. Cosgrove, 2023, Journal of Biological Chemistry

Cheng Xu, Holly Kleinschmidt, Jianyu Yang, Erik Leith, Jenna Johnson, Song Tan, S Mahony, L Bai, 2023, bioRxiv

Robert K. McGinty, Song Tan, 2021, Current Opinion in Structural Biology on p. 16-26

Ryan T. Santilli, John E. Williamson, Yoshitaka Shibata, Rosalie P. Sowers, Andrew N. Fleischman, Song Tan, 2021, Scientific Reports

Jose M. Espinola-Lopez, Song Tan, 2021, Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Most-Cited Papers

Robert K. McGinty, Song Tan, 2015, Chemical Reviews on p. 2255-2273

Robert K. McGinty, Song Tan, 2016, Current Opinion in Structural Biology on p. 54-61

S Kim, J Zhu, Neela Yennawar, P Eek, Song Tan, 2020, Molecular Cell on p. 903-914.e4

Robert K. McGinty, Song Tan, 2021, Current Opinion in Structural Biology on p. 16-26

Jian Sun, Marcin Paduch, Sang Ah Kim, Ryan M. Kramer, Adam F. Barrios, Vincent Lu, Judy Luke, Svitlana Usatyuk, Anthony A. Kossiakoff, Song Tan, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 10010-10015

Sang Ah Kim, Nilanjana Chatterjee, Matthew J. Jennings, Blaine Bartholomew, Song Tan, 2015, Nucleic Acids Research on p. 4868-4880

Jose M. Espinola-Lopez, Song Tan, 2021, Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Stamatios Liokatis, Rebecca Klingberg, Song Tan, Dirk Schwarzer, 2016, Angewandte Chemie - International Edition on p. 8262-8265

Laura C. Lehmann, Luka Bacic, Graeme Hewitt, Klaus Brackmann, Anton Sabantsev, Guillaume Gaullier, Sofia Pytharopoulou, Gianluca Degliesposti, Hanneke Okkenhaug, Song Tan, Alessandro Costa, J. Mark Skehel, Simon J. Boulton, Sebastian Deindl, 2020, Cell Reports

Taverekere S. Girish, Robert K. McGinty, Song Tan, 2016, Journal of Molecular Biology on p. 1531-1543

News Articles Featuring Song Tan

Optical tweezers help elevate single-molecule research at Penn State

The instrument, supported by a new NIH infrastructure grant, uses laser light to ‘tweeze’ tiny objects like DNA molecules and proteins.

How 'master regulators' of cells make DNA accessible for gene expression

New insight into proteins called “pioneer factors” helps to explain their unusual ability to open up the typically dense genetic material within our cells. This behavior makes the genetic material accessible for proteins involved in important cellular processes, such as DNA replication and repair, gene expression, and the creation of proteins.

How does an aging-associated enzyme access our genetic material?

New research provides insight into how an enzyme that helps regulate aging and other metabolic processes accesses our genetic material to modulate gene expression within the cell. A team led by Penn State researchers have produced images of a sirtuin enzyme bound to a nucleosome — a tightly packed complex of DNA and proteins called histones — showing how the enzyme navigates the nucleosome complex to access both DNA and histone proteins and clarifying how it functions in humans and other animals.

New image of a cancer-related enzyme in action helps explain gene regulation

New images of an enzyme in action as it interacts with the chromosome could provide important insight into how cells — including cancer cells — regulate their genes.