Song Tan

Director of the Center for Eukaryotic Gene Regulation; Professor of Biochemistry and Molecular Biology

468A North Frear Laboratory
University Park, PA 16802
sxt30@psu.edu
814-865-3355

Research Summary

Structural biology of eukaryotic gene regulation.

Huck Graduate Students

Jose Espinola Lopez

Huck Affiliations

Molecular, Cellular, and Integrative Biosciences

Center for Eukaryotic Gene Regulation

Center for Structural Biology

Publication Tags

Nucleosomes Histones Enzymes Chromatin Histone Acetyltransferases Proteins Dna Histone Demethylases Histone Histone Methyltransferases Histone Methyltransferase Crosstalk Molecular Weight Ubiquitination Nuclear Magnetic Resonance Spectroscopy Isotopes Eukaryota Plasmids Arginine Methylation Modification Escherichia Coli Genome Recombinant Proteins Lysine

Most Recent Publications

The Penn State Protein Ladder system for inexpensive protein molecular weight markers

Ryan T. Santilli, John E. Williamson, Yoshitaka Shibata, Rosalie P. Sowers, Andrew N. Fleischman, Song Tan, 2021, Scientific Reports

Principles of nucleosome recognition by chromatin factors and enzymes

Robert K. McGinty, Song Tan, 2021, Current Opinion in Structural Biology on p. 16-26

The Ada2/Ada3/Gcn5/Sgf29 histone acetyltransferase module

Jose M. Espinola-Lopez, Song Tan, 2021, Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch

Laura C. Lehmann, Luka Bacic, Graeme Hewitt, Klaus Brackmann, Anton Sabantsev, Guillaume Gaullier, Sofia Pytharopoulou, Gianluca Degliesposti, Hanneke Okkenhaug, Song Tan, Alessandro Costa, J. Mark Skehel, Simon J. Boulton, Sebastian Deindl, 2020, Cell Reports

Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate

Sang Ah Kim, Jiang Zhu, Neela Yennawar, Priit Eek, Song Tan, 2020, Molecular Cell on p. 903-914.e4

Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2

Jian Sun, Marcin Paduch, Sang Ah Kim, Ryan M. Kramer, Adam F. Barrios, Vincent Lu, Judy Luke, Svitlana Usatyuk, Anthony A. Kossiakoff, Song Tan, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 10010-10015

The pPSU Plasmids for Generating DNA Molecular Weight Markers

Ryan C. Henrici, Turner J. Pecen, James L. Johnston, Song Tan, 2017, Scientific Reports

Elimination of truncated recombinant protein expressed in Escherichia coli by removing cryptic translation initiation site

Matthew J. Jennings, Adam F. Barrios, Song Tan, 2016, Protein Expression and Purification on p. 17-21

Multivalent interactions by the set8 histone methyltransferase with its nucleosome substrate

Taverekere S. Girish, Robert K. McGinty, Song Tan, 2016, Journal of Molecular Biology on p. 1531-1543

Recognition of the nucleosome by chromatin factors and enzymes

Robert K. McGinty, Song Tan, 2016, Current Opinion in Structural Biology on p. 54-61

Most-Cited Papers

Nucleosome structure and function

Robert K. McGinty, Song Tan, 2015, Chemical Reviews on p. 2255-2273

Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome

Robert K. McGinty, Ryan C. Henrici, Song Tan, 2014, Nature on p. 591-596

Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity

Marie Eve Lalonde, Nikita Avvakumov, Karen C. Glass, France Hélène Joncas, Nehmé Saksouk, Michael Holliday, Eric Paquet, Kezhi Yan, Qiong Tong, Brianna J. Klein, Song Tan, Xiang Jiao Yang, Tatiana G. Kutateladze, Jacques Côté, 2013, Genes and Development on p. 2009-2024

Recognition of the nucleosome by chromatin factors and enzymes

Robert K. McGinty, Song Tan, 2016, Current Opinion in Structural Biology on p. 54-61

ASH2L regulates ubiquitylation signaling to MLL

Lipeng Wu, Shirley Y. Lee, Bo Zhou, Uyen T.T. Nguyen, Tom W. Muir, Song Tan, Yali Dou, 2013, Molecular Cell on p. 1108-1120

Extranucleosomal DNA enhances the activity of the LSD1/CoREST histone demethylase complex

Sang Ah Kim, Nilanjana Chatterjee, Matthew J. Jennings, Blaine Bartholomew, Song Tan, 2015, Nucleic Acids Research on p. 4868-4880

Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate

Sang Ah Kim, Jiang Zhu, Neela Yennawar, Priit Eek, Song Tan, 2020, Molecular Cell on p. 903-914.e4

Differentially Isotope-Labeled Nucleosomes To Study Asymmetric Histone Modification Crosstalk by Time-Resolved NMR Spectroscopy

Stamatios Liokatis, Rebecca Klingberg, Song Tan, Dirk Schwarzer, 2016, Angewandte Chemie - International Edition on p. 8262-8265