Song Tan

Director of the Center for Eukaryotic Gene Regulation; Professor of Biochemistry and Molecular Biology

Song Tan

Research Summary

Structural biology of eukaryotic gene regulation.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Nucleosomes Histones Histone Acetyltransferases Acetylation Chromatin Dna Enzymes Histone Methyltransferase Histone Methyltransferases Crosstalk Histone Demethylases Ubiquitination Isotopes Nuclear Magnetic Resonance Spectroscopy Proteins Eukaryota Yeasts Methylation Chromatin Assembly And Disassembly Adenosine Triphosphate Escherichia Coli Post Translational Protein Processing Lysine Sucrose Molecular Weight

Most Recent Papers

The Ada2/Ada3/Gcn5/Sgf29 histone acetyltransferase module.

J Espinola-Lopez, Song Tan, 2021, Biochimica et biophysica acta. Gene regulatory mechanisms on p. 194629

Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch.

L Lehmann, L Bacic, G Hewitt, K Brackmann, A Sabantsev, G Gaullier, S Pytharopoulou, G Degliesposti, H Okkenhaug, Song Tan, A Costa, J Skehel, S Boulton, S Deindl, 2020, Cell reports on p. 108529

Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate

Sang Ah Kim, Jiang Zhu, Neela Yennawar, Priit Eek, Song Tan, 2020, Molecular Cell on p. 903-914.e4

The Ada2/Ada3/Gcn5/Sgf29 histone acetyltransferase module

Jose M. Espinola-Lopez, Song Tan, 2020, Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2

Jian Sun, Marcin Paduch, Sang Ah Kim, Ryan M. Kramer, Adam F. Barrios, Vincent Lu, Judy Luke, Svitlana Usatyuk, Anthony A. Kossiakoff, Song Tan, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 10010-10015

The pPSU Plasmids for Generating DNA Molecular Weight Markers

Ryan C. Henrici, Turner J. Pecen, James L. Johnston, Song Tan, 2017, Scientific Reports

Elimination of truncated recombinant protein expressed in Escherichia coli by removing cryptic translation initiation site

Matthew J. Jennings, Adam F. Barrios, Song Tan, 2016, Protein Expression and Purification on p. 17-21

Multivalent interactions by the set8 histone methyltransferase with its nucleosome substrate

Taverekere S. Girish, Robert K. McGinty, Song Tan, 2016, Journal of Molecular Biology on p. 1531-1543

Preparation, Crystallization, and Structure Determination of Chromatin Enzyme/Nucleosome Complexes.

R McGinty, R Makde, Song Tan, 2016, Methods in enzymology on p. 43-65

Recognition of the nucleosome by chromatin factors and enzymes

Robert McGinty, Song Tan, 2016, CURRENT OPINION IN STRUCTURAL BIOLOGY on p. 54-61

Most-Cited Papers

Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome

Robert K. McGinty, Ryan C. Henrici, Song Tan, 2014, Nature on p. 591-596

Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity

Marie Eve Lalonde, Nikita Avvakumov, Karen C. Glass, France Hélène Joncas, Nehmé Saksouk, Michael Holliday, Eric Paquet, Kezhi Yan, Qiong Tong, Brianna J. Klein, Song Tan, Xiang Jiao Yang, Tatiana G. Kutateladze, Jacques Côté, 2013, Genes and Development on p. 2009-2024

Histone H3 tail acetylation modulates ATP-dependent remodeling through multiple mechanisms

Nilanjana Chatterjee, Divya Sinha, Mekonnen Lemma-Dechassa, Song Tan, Michael A. Shogren-Knaak, Blaine Bartholomew, 2011, Nucleic Acids Research on p. 8378-8391

Structure and nucleosome interaction of the yeast NuA4 and Piccolo-NuA4 histone acetyltransferase complexes

Johnathan R. Chittuluru, Yuriy Chaban, Julie Monnet-Saksouk, Michael J. Carrozza, Vasileia Sapountzi, William Selleck, Jiehuan Huang, Rhea T. Utley, Myriam Cramet, Stephane Allard, Gang Cai, Jerry L. Workman, Michael G. Fried, Song Tan, Jacques Côté, Francisco J. Asturias, 2011, Nature Structural and Molecular Biology on p. 1196-1203

ASH2L regulates ubiquitylation signaling to MLL

Lipeng Wu, Shirley Y. Lee, Bo Zhou, Uyen T T Nguyen, Tom W. Muir, Song Tan, Yali Dou, 2013, Molecular Cell on p. 1108-1120

Extranucleosomal DNA enhances the activity of the LSD1/CoREST histone demethylase complex

Sang Ah Kim, Nilanjana Chatterjee, Matthew J. Jennings, Blaine Bartholomew, Song Tan, 2015, Nucleic Acids Research on p. 4868-4880

Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress

Georgette M. Charles, Changbin Chen, Susan C. Shih, Sean R. Collins, Pedro Beltrao, Xin Zhang, Tanu Sharma, Song Tan, Alma L. Burlingame, Nevan J. Krogan, Hiten D. Madhani, Geeta J. Narlikar, 2011, Proceedings of the National Academy of Sciences of the United States of America on p. 10620-10625

Piccolo NuA4-catalyzed acetylation of nucleosomal histones

Jiehuan Huang, Song Tan, 2013, Molecular and Cellular Biology on p. 159-169

Multivalent interactions by the set8 histone methyltransferase with its nucleosome substrate

Taverekere S. Girish, Robert K. McGinty, Song Tan, 2016, Journal of Molecular Biology on p. 1531-1543

Differentially Isotope-Labeled Nucleosomes To Study Asymmetric Histone Modification Crosstalk by Time-Resolved NMR Spectroscopy

Stamatios Liokatis, Rebecca Klingberg, Song Tan, Dirk Schwarzer, 2016, Angewandte Chemie - International Edition on p. 8262-8265