David Boehr

Associate Professor of Chemistry

107 Chemistry
University Park, PA
ddb12@psu.edu
814-863-8605

Bio & Links
Publications

Research Summary

The role of protein dynamics in enzyme function, coordination and regulation

Huck Affiliations

Center for Structural Biology

Publication Tags

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Proteins Amino Acids Enzymes Rna Replicase Nucleotides Protein Acid Tryptophan Synthase Magnetic Resonance Spectroscopy Tryptophan Structural Dynamics Nucleotide Viral Rna Poliovirus Rna Nuclear Magnetic Resonance Computational Methods Biotechnology Nmr Spectroscopy Catalyst Triphosphoric Acid Catalysts Drug Substitution Reaction Antiviral Agents

Most Recent Publications

Editorial: Allosteric functions and inhibitions: structural insights

David D. Boehr, 2024, Frontiers in Molecular Biosciences

Picornavirus 3C Proteins Intervene in Host Cell Processes through Proteolysis and Interactions with RNA

Somnath Mondal, Gisoo Sarvari, David D. Boehr, 2023, Viruses

Allostery, engineering and inhibition of tryptophan synthase

Rebecca N. D'Amico, David D. Boehr, 2023, Current Opinion in Structural Biology

Direct interactions between picornavirus 3CD protein and phosphoinositide lipids in virus replication organelles

David D. Boehr, Dennis S. Winston, Jie Yu, 2023, Biophysical Journal on p. 30a-31a

Regulatory mechanisms triggered by enzyme interactions with lipid membrane surfaces

Jie Yu, David D. Boehr, 2023, Frontiers in Molecular Biosciences

Special Issue “10th Anniversary of Catalysts: Biocatalysis in Analysis and Synthesis—Past, Present and Future”

Evangelos Topakas, David Boehr, Roland Wohlgemuth, 2022, Catalysts

Catalyst-Based Biomolecular Logic Gates

Dennis S. Winston, David D. Boehr, 2022, Catalysts

Allosteric networks regulate function in multi-enzyme complexes

David D. Boehr, Rebecca D'Amico, Kathleen O'Rourke, Yuliana Bosken, Debashish Sahu, Chia En Chang, 2022, FASEB Journal

Differences in Conformational Dynamics Between a Viral Polyprotein and Its Processed Products in Functionally Relevant Regions Revealed by Solution-State NMR Spectroscopy

Dennis Winston, David Boehr, 2022, FASEB Journal

Conformational Transitions in Yeast Chorismate Mutase Important for Allosteric Regulation as Identified by Nuclear Magnetic Resonance Spectroscopy

Dennis S. Winston, Scott D. Gorman, David D. Boehr, 2022, Journal of Molecular Biology

Most-Cited Papers

The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family

Lonneke van der Linden, Laia Vives-Adrián, Barbara Selisko, Cristina Ferrer-Orta, Xinran Liu, Kjerstin Lanke, Rachel Ulferts, Armando M. De Palma, Federica Tanchis, Nesya Goris, David Lefebvre, Kris De Clercq, Pieter Leyssen, Céline Lacroix, Gerhard Pürstinger, Bruno Coutard, Bruno Canard, David D. Boehr, Jamie J. Arnold, Craig E. Cameron, Nuria Verdaguer, Johan Neyts, Frank J.M. van Kuppeveld, 2015, PLoS Pathogens on p. 1-23

Biophysical and computational methods to analyze amino acid interaction networks in proteins

Kathleen F. O'Rourke, Scott D. Gorman, David D. Boehr, 2016, Computational and Structural Biotechnology Journal on p. 245-251

Amino acid networks in a (β/α)<sub>8</sub> barrel enzyme change during catalytic turnover

Jennifer M. Axe, Eric M. Yezdimer, Kathleen F. Orourke, Nicole E. Kerstetter, Wanli You, Chia En A. Chang, David D. Boehr, 2014, Journal of the American Chemical Society on p. 6818-6821

Engineered control of enzyme structural dynamics and function

David D. Boehr, Rebecca N. D'Amico, Kathleen F. O'Rourke, 2018, Protein Science on p. 825-838

Structural dynamics as a contributor to error-prone replication by an RNA-dependent RNA polymerase

Ibrahim M. Moustafa, Victoria K. Korboukh, Jamie J. Arnold, Eric D. Smidansky, Laura L. Marcotte, David W. Gohara, Xiaorong Yang, María Antonieta Saánchez-Farraán, David Filman, Janna K. Maranas, David D. Boehr, James M. Hogle, Coray M. Colina, Craig E. Cameron, 2014, Journal of Biological Chemistry on p. 36229-36248

Severing of a hydrogen bond disrupts amino acid networks in the catalytically active state of the alpha subunit of tryptophan synthase

Jennifer M. Axe, Kathleen F. O'Rourke, Nicole E. Kerstetter, Eric M. Yezdimer, Yan M. Chan, Alexander Chasin, David D. Boehr, 2015, Protein Science on p. 484-494