Katsuhiko Murakami

Professor of Biochemistry and Molecular Biology

Katsuhiko Murakami

Research Summary

Structural and Mechanistic Enzymology of Prokaryotic RNA Polymerases

Huck Affiliations

Links

Publication Tags

Dna Directed Rna Polymerases X Rays Dna Escherichia Coli Holoenzymes Transcription Rna Crystal Structure Bacterial Rna Transcription Factors Archaeal Rna Rifampin Rna Polymerase Ii Mycobacterium Tuberculosis Dna Directed Dna Polymerase Archaea Binding Sites In Vitro Techniques Bacteria Mutation Enzymes Peptide Elongation Factors Proteins Catalytic Domain Growth

Most Recent Papers

Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase.

Y Shin, Mark Hedglin, Katsuhiko Murakami, 2020, Nucleic acids research

Structure and function of an unusual flavodoxin from the domain Archaea

Divya Prakash, Prashanti R. Iyer, Suharti Suharti, Karim A. Walters, Michel Geovanni Santiago-Martinez, John H. Golbeck, Katsuhiko S. Murakami, James G. Ferry, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 25917-25922

Molecular basis of microhomology-mediated end-joining by purified full-length Polθ

Samuel J. Black, Ahmet Y. Ozdemir, Ekaterina Kashkina, Tatiana Kent, Timur Rusanov, Dejan Ristic, Yeonoh Shin, Antonio Suma, Trung Hoang, Gurushankar Chandramouly, Labiba A. Siddique, Nikita Borisonnik, Katherine Sullivan-Reed, Joseph S. Mallon, Tomasz Skorski, Vincenzo Carnevale, Katsuhiko S. Murakami, Claire Wyman, Richard T. Pomerantz, 2019, Nature communications on p. 4423

Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis

Hamed Mosaei, Vadim Molodtsov, Bernhard Kepplinger, John Harbottle, Christopher William Moon, Rose Elizabeth Jeeves, Lucia Ceccaroni, Yeonoh Shin, Stephanie Morton-Laing, Emma Claire Louise Marrs, Corinne Wills, William Clegg, Yulia Yuzenkova, John David Perry, Joanna Bacon, Jeff Errington, Nicholas Edward Ellis Allenby, Michael John Hall, Katsuhiko Murakami, Nikolay Zenkin, 2018, Molecular cell on p. 263-274.e5

An Introduction to the Structure and Function of the Catalytic Core Enzyme of <i>Escherichia coli</i> RNA Polymerase.

C Sutherland, Katsuhiko Murakami, 2018, EcoSal Plus

Structure-function comparisons of (p)ppApp vs (p)ppGpp for Escherichia coli RNA polymerase binding sites and for rrnB P1 promoter regulatory responses in vitro

Bożena Bruhn-Olszewska, Vadim Molodtsov, Michał Sobala, Maciej Dylewski, Katsuhiko Murakami, Michael Cashel, Katarzyna Potrykus, 2018, Biochimica et Biophysica Acta - Gene Regulatory Mechanisms on p. 731-742

Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA

Vadim Molodtsov, Elena V. Sineva, Lu Zhang, Xuhui Huang, Michael Cashel, Sarah Ellen Ades, Katsuhiko Murakami, 2018, Molecular cell on p. 828-839.e5

Cryo-EM structure of Escherichia coli <sup>70</sup> RNA polymerase and promoter DNA complex revealed a role of non-conserved region during the open complex formation

Anoop Narayanan, Frank S. Vago, Kunpeng Li, M. Zuhaib Qayyum, Dinesh Yernool, Wen Jiang, Katsuhiko S. Murakami, 2018, Journal of Biological Chemistry on p. 7367-7375

Minimalism and functionality

Vadim Molodtsov, Katsuhiko Murakami, 2018, Journal of Biological Chemistry on p. 13616-13625

Region 3.2 of the factor controls the stability of rRNA promoter complexes and potentiates their repression by DksA

Danil Pupov, Ivan Petushkov, Daria Esyunina, Katsuhiko S. Murakami, Andrey Kulbachinskiy, 2018, Nucleic acids research on p. 11477-11487

Most-Cited Papers

X-ray crystal structure of escherichia coli RNA polymerase σ<sup>70</sup> holoenzyme

Katsuhiko S. Murakami, 2013, Journal of Biological Chemistry on p. 9126-9134

Differential regulation by ppGpp versus pppGpp in Escherichia coli

Undine Mechold, Katarzyna Potrykus, Helen Murphy, Katsuhiko Murakami, Michael Cashel, 2013, Nucleic acids research on p. 6175-6189

RNA polymerase and transcription elongation factor Spt4/5 complex structure

Brianna J. Klein, Daniel Bose, Kevin J. Baker, Zahirah M. Yusoff, Xiaodong Zhang, Katsuhiko Murakami, 2011, Proceedings of the National Academy of Sciences of the United States of America on p. 557-562

Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme

Ritwika S. Basu, Brittany A. Warner, Vadim Molodtsov, Danil Pupov, Daria Esyunina, Carlos Fernández-Tornero, Andrey Kulbachinskiy, Katsuhiko S. Murakami, 2014, Journal of Biological Chemistry on p. 24549-24559

Fitness costs of rifampicin resistance in Mycobacterium tuberculosis are amplified under conditions of nutrient starvation and compensated by mutation in the β′ subunit of RNA polymerase

Taeksun Song, Yumi Park, Isdore Chola Shamputa, Sunghwa Seo, Sun Young Lee, Han Seung Jeon, Hongjo Choi, Myungsun Lee, Richard J. Glynne, S. Whitney Barnes, John R. Walker, Serge Batalov, Karina Yusim, Shihai Feng, Chang Shung Tung, James Theiler, Laura E. Via, Helena I.M. Boshoff, Katsuhiko Murakami, Bette Korber, Clifton E. Barry, Sang Nae Cho, 2014, Molecular Microbiology on p. 1106-1119

Archaeal RNA polymerase and transcription regulation

Sung Hoon Jun, Matthew J. Reichlen, Momoko Tajiri, Katsuhiko Murakami, 2011, Critical Reviews in Biochemistry and Molecular Biology on p. 27-40

X-ray crystal structures of the Escherichia coli RNA polymerase in complex with benzoxazinorifamycins

Vadim Molodtsov, Irosha N. Nawarathne, Nathan T. Scharf, Paul D. Kirchhoff, H. D.Hollis Showalter, George A. Garcia, Katsuhiko Murakami, 2013, Journal of Medicinal Chemistry on p. 4758-4763

Structures of the RNA polymerase-σ<sup>54</sup> reveal new and conserved regulatory strategies

Yun Yang, Vidya C. Darbari, Nan Zhang, Duo Lu, Robert Glyde, Yi Ping Wang, Jared T. Winkelman, Richard L. Gourse, Katsuhiko S. Murakami, Martin Buck, Xiaodong Zhang, 2015, Science on p. 882-885

NusG is a sequence-specific RNA polymerase pause factor that binds to the non-template DNA within the paused transcription bubble

Alexander V. Yakhnin, Katsuhiko S. Murakami, Paul Babitzke, 2016, Journal of Biological Chemistry on p. 5299-5308

The X-ray crystal structure of the euryarchaeal RNA polymerase in an open-clamp configuration

Sung Hoon Jun, Akira Hirata, Tamotsu Kanai, Thomas J. Santangelo, Tadayuki Imanaka, Katsuhiko S. Murakami, 2014, Nature communications