Mark Hedglin

Assistant Professor of Chemistry; Assistant Professor of Biochemistry and Molecular Biology

Mark Hedglin

Research Summary

Deciphering how efficient and faithful replication of the human genome is achieved within the highly-complex, dynamic, and reactive environment of the nucleus. Identifying pathways for genomic instability in humans, identifying novel oncogenic drug targets, developing better chemotherapeutic treatments for human cancers caused by genomic instability.

Huck Affiliations

Publication Tags

Dna Proliferating Cell Nuclear Antigen Replication Protein A Protein Antigen Dna Directed Dna Polymerase Proteins Holoenzymes Single Stranded Dna Clamping Devices Damage Tolerance Binding Sites Mutation Cell Viability Diffusion Protein Binding Haemophilus Influenzae Type B Polysaccharide Vaccine Diphtheria Replication Protein C Antineoplastic Agent Genes Dna Damage Modification Ubiquitin Dna Replication Loaders

Most Recent Publications

Rachel L. Dannenberg, Joseph A. Cardina, Kara G. Pytko, Mark Hedglin, 2022, Nucleic Acids Research on p. 9893-9908

Christl Gaubitz, Xingchen Liu, Joseph Magrino, Nicholas P. Stone, Jacob Landeck, Mark Hedglin, Brian A. Kelch, 2020, Proceedings of the National Academy of Sciences of the United States of America on p. 23571-23580

Yeonoh Shin, Mark Hedglin, Katsuhiko S. Murakami, 2020, Nucleic Acids Research on p. 2144-2155

Rad6/Rad18 Competes with DNA Polymerases ν and δfor PCNA Encircling DNA

Mingjie Li, Leah Larsen, Mark Hedglin, 2020, Biochemistry on p. 407-416

Mingjie Li, Bhaswati Sengupta, Stephen J. Benkovic, Tae Hee Lee, Mark Hedglin, 2020, Biochemistry on p. 4694-4702

Rad6/Rad18 competes with DNA polymerases ? and ? for PCNA encircling DNA

Mingjie Li, Leah Larsen, Mark Hedglin, 2019, Biochemistry on p. 407-416

Mark Hedglin, Mahesh Aitha, Anthony Pedley, Stephen Benkovic, 2019, Journal of Biological Chemistry on p. 5157-5168

Mark Hedglin, Mahesh Aitha, Anthony Pedley, S Benkovic, 2019, JOURNAL OF BIOLOGICAL CHEMISTRY on p. 20

Mark Hedglin, Stephen J. Benkovic, 2017, Chemical Reviews on p. 7857-7877

Most-Cited Papers

Mark Hedglin, Ravindra Kumar, Stephen J. Benkovic, 2013, Cold Spring Harbor perspectives in biology on p. 1-19

Mark Hedglin, Stephen J. Benkovic, 2015, Annual Review of Biophysics and Biomolecular Structure on p. 207-228

Mark Hedglin, Binod Pandey, Stephen J. Benkovic, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. E1777-E1786

Mark Hedglin, Binod Pandey, Stephen J. Benkovic, 2016, eLife

Mark Hedglin, Stephen J. Benkovic, 2017, Chemical Reviews on p. 7857-7877

Mark Hedglin, Yaru Zhang, Patrick J. O'Brien, 2013, Journal of Biological Chemistry on p. 24550-24559

Mark Hedglin, Senthil K. Perumal, Zhenxin Hu, Stephen Benkovic, 2013, eLife

Mark Hedglin, Mahesh Aitha, Anthony Pedley, Stephen Benkovic, 2019, Journal of Biological Chemistry on p. 5157-5168

Christl Gaubitz, Xingchen Liu, Joseph Magrino, Nicholas P. Stone, Jacob Landeck, Mark Hedglin, Brian A. Kelch, 2020, Proceedings of the National Academy of Sciences of the United States of America on p. 23571-23580

Mark Hedglin, Stephen J. Benkovic, 2017, Biochemistry on p. 1824-1835