Mark Hedglin

Assistant Professor of Chemistry; Assistant Professor of Biochemistry and Molecular Biology

Mark Hedglin

Research Summary

Deciphering how efficient and faithful replication of the human genome is achieved within the highly-complex, dynamic, and reactive environment of the nucleus. Identifying pathways for genomic instability in humans, identifying novel oncogenic drug targets, developing better chemotherapeutic treatments for human cancers caused by genomic instability.

Huck Affiliations

Publication Tags

Dna Proliferating Cell Nuclear Antigen Proteins Single Stranded Dna Binding Sites Clamping Devices Holoenzymes Replication Protein A Nucleotides Dna Glycosylases 3 Methyladenine Dna Glycosylase Genes Damage Tolerance Protein Binding Haemophilus Influenzae Type B Polysaccharide Vaccine Diphtheria Amino Acids Dna Directed Dna Polymerase Molecular Sequence Data Dna Damage Loaders Facilitated Diffusion Ubiquitin Dna Binding Proteins Monitoring Nucleic Acid Conformation

Most Recent Papers

Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen

Mark Hedglin, Mahesh Aitha, Anthony Pedley, Stephen J. Benkovic, 2019, Journal of Biological Chemistry on p. 5157-5168

Monitoring the Retention of Human Proliferating Cell Nuclear Antigen at Primer/Template Junctions by Proteins That Bind Single-Stranded DNA

Mark Hedglin, Mahesh Aitha, Stephen J. Benkovic, 2017, Biochemistry on p. 3415-3421

Replication Protein A Prohibits Diffusion of the PCNA Sliding Clamp along Single-Stranded DNA

Mark Hedglin, Stephen J. Benkovic, 2017, Biochemistry on p. 1824-1835

Characterization of human translesion DNA synthesis across a UV-induced DNA lesion

Mark Hedglin, Binod Pandey, Stephen J. Benkovic, 2016, eLife

Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis

Mark Hedglin, Binod Pandey, Stephen J. Benkovic, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. E1777-E1786

Regulation of Rad6/Rad18 Activity during DNA Damage Tolerance

Mark Hedglin, Stephen Benkovic, 2015, Annual Review of Biophysics on p. 207-228

Probing the DNA structural requirements for facilitated diffusion

Mark Hedglin, Yaru Zhang, Patrick J. O'Brien, 2015, Biochemistry on p. 557-566

Isolating contributions from intersegmental transfer to DNA searching by alkyladenine DNA glycosylase

Mark Hedglin, Yaru Zhang, Patrick J. O'Brien, 2013, Journal of Biological Chemistry on p. 24550-24559

Stepwise assembly of the human replicative polymerase holoenzyme

Mark Hedglin, Senthil K. Perumal, Zhenxin Hu, Stephen Benkovic, 2013, eLife

Replication clamps and clamp loaders

Mark Hedglin, Ravindra Kumar, Stephen J. Benkovic, 2013, Cold Spring Harbor Perspectives in Biology on p. 1-19

Most-Cited Papers

Replication clamps and clamp loaders

Mark Hedglin, Ravindra Kumar, Stephen J. Benkovic, 2013, Cold Spring Harbor Perspectives in Biology on p. 1-19

Hopping enables a DNA repair glycosylase to search both strands and bypass a bound protein

Mark Hedglin, Patrick J. O'Brien, 2010, ACS chemical biology on p. 427-436

Regulation of Rad6/Rad18 Activity during DNA Damage Tolerance

Mark Hedglin, Stephen Benkovic, 2015, Annual Review of Biophysics on p. 207-228

Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis

Mark Hedglin, Binod Pandey, Stephen J. Benkovic, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. E1777-E1786

Characterization of human translesion DNA synthesis across a UV-induced DNA lesion

Mark Hedglin, Binod Pandey, Stephen J. Benkovic, 2016, eLife

Isolating contributions from intersegmental transfer to DNA searching by alkyladenine DNA glycosylase

Mark Hedglin, Yaru Zhang, Patrick J. O'Brien, 2013, Journal of Biological Chemistry on p. 24550-24559

Stepwise assembly of the human replicative polymerase holoenzyme

Mark Hedglin, Senthil K. Perumal, Zhenxin Hu, Stephen Benkovic, 2013, eLife

Replication Protein A Prohibits Diffusion of the PCNA Sliding Clamp along Single-Stranded DNA

Mark Hedglin, Stephen J. Benkovic, 2017, Biochemistry on p. 1824-1835

Probing the DNA structural requirements for facilitated diffusion

Mark Hedglin, Yaru Zhang, Patrick J. O'Brien, 2015, Biochemistry on p. 557-566

Monitoring the Retention of Human Proliferating Cell Nuclear Antigen at Primer/Template Junctions by Proteins That Bind Single-Stranded DNA

Mark Hedglin, Mahesh Aitha, Stephen J. Benkovic, 2017, Biochemistry on p. 3415-3421