Mark Hedglin

Assistant Professor of Chemistry; Assistant Professor of Biochemistry and Molecular Biology

Mark Hedglin

Research Summary

Deciphering how efficient and faithful replication of the human genome is achieved within the highly-complex, dynamic, and reactive environment of the nucleus. Identifying pathways for genomic instability in humans, identifying novel oncogenic drug targets, developing better chemotherapeutic treatments for human cancers caused by genomic instability.

Huck Graduate Students

Huck Affiliations

Publication Tags

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Dna Proliferating Cell Nuclear Antigen Replication Protein A Protein Antigen Single Stranded Dna Proteins Dna Directed Dna Polymerase Diffusion Nucleotides Binding Sites Damage Tolerance Dna Damage Modification Holoenzymes Haemophilus Influenzae Type B Polysaccharide Vaccine Diphtheria Amino Acids Replication Protein C Filament Clamping Devices Nucleotide Ubiquitin Cell Viability Mutation Dna Binding Proteins

Most Recent Publications

Susanna Stroik, Juan Carvajal-Garcia, Dipika Gupta, Alyssa Edwards, Adam Luthman, David W. Wyatt, Rachel L. Dannenberg, Wanjuan Feng, Thomas A. Kunkel, Gaorav P. Gupta, Mark Hedglin, Richard Wood, Sylvie Doublié, Eli Rothenberg, Dale A. Ramsden, 2023, Nature on p. 836-841

Nicole M. Hoitsma, Jessica Norris, Thu H. Khoang, Vikas Kaushik, Rahul Chadda, Edwin Antony, Mark Hedglin, Bret D. Freudenthal, 2023, Nucleic Acids Research on p. 6738-6753

Rachel L. Dannenberg, Joseph A. Cardina, Kara G. Pytko, Mark Hedglin, 2022, Nucleic Acids Research on p. 9893-9908

Christl Gaubitz, Xingchen Liu, Joseph Magrino, Nicholas P. Stone, Jacob Landeck, Mark Hedglin, Brian A. Kelch, 2020, Proceedings of the National Academy of Sciences of the United States of America on p. 23571-23580

Yeonoh Shin, Mark Hedglin, Katsuhiko S. Murakami, 2020, Nucleic Acids Research on p. 2144-2155

Rad6/Rad18 Competes with DNA Polymerases ν and δfor PCNA Encircling DNA

Mingjie Li, Leah Larsen, Mark Hedglin, 2020, Biochemistry on p. 407-416

Mingjie Li, Bhaswati Sengupta, Stephen J. Benkovic, Tae Hee Lee, Mark Hedglin, 2020, Biochemistry on p. 4694-4702

Rad6/Rad18 competes with DNA polymerases ? and ? for PCNA encircling DNA

Mingjie Li, Leah Larsen, Mark Hedglin, 2019, Biochemistry on p. 407-416

Mark Hedglin, Mahesh Aitha, Anthony Pedley, Stephen Benkovic, 2019, Journal of Biological Chemistry on p. 5157-5168

Mark Hedglin, Mahesh Aitha, Anthony Pedley, S Benkovic, 2019, JOURNAL OF BIOLOGICAL CHEMISTRY on p. 20

Most-Cited Papers

Mark Hedglin, Stephen J. Benkovic, 2015, Annual Review of Biophysics and Biomolecular Structure on p. 207-228

Mark Hedglin, Binod Pandey, Stephen J. Benkovic, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. E1777-E1786

Mark Hedglin, Binod Pandey, Stephen J. Benkovic, 2016, eLife

Mark Hedglin, Stephen J. Benkovic, 2017, Chemical Reviews on p. 7857-7877

Christl Gaubitz, Xingchen Liu, Joseph Magrino, Nicholas P. Stone, Jacob Landeck, Mark Hedglin, Brian A. Kelch, 2020, Proceedings of the National Academy of Sciences of the United States of America on p. 23571-23580

Mark Hedglin, Mahesh Aitha, Anthony Pedley, Stephen Benkovic, 2019, Journal of Biological Chemistry on p. 5157-5168

Mark Hedglin, Stephen J. Benkovic, 2017, Biochemistry on p. 1824-1835

Mark Hedglin, Yaru Zhang, Patrick J. O'Brien, 2015, Biochemistry on p. 557-566

Mingjie Li, Bhaswati Sengupta, Stephen J. Benkovic, Tae Hee Lee, Mark Hedglin, 2020, Biochemistry on p. 4694-4702