People: Molecular Toxicology
Associate Chair, Molecular Cellular and Integrative Biosciences; Emphasis Area Representative, Cancer Biology; Professor of Molecular Toxicology and Carcinogenesis;
Research in my lab focuses on the role of Transforming Growth Factor-beta in cutaneous inflammation and cancer development, and how the immune system responds to epithelial cells with activated oncogenes such as Ras. We are also interested in signaling pathways that regulate senescence of premalignant epithelial cells and how cells escape from oncogene-induced senescence.
Assistant Professor of Veterinary and Biomedical Sciences
Building tools to elucidate the complex genetic and environmental underpinnings of human disease. Integrating genetic (genotype, sequence, structural variation) and exposure (derived from surveys and metabolomics methods) big data to predict disease status.
Associate Director for Strategic Initiatives, Huck Institutes of the Life Sciences; Huck Distinguished Chair in Global Health; Professor of Microbiology and Infectious Diseases
The basic mechanisms by which pathogenic microbes successfully infect, colonize, and cause disease in their hosts.
Associate Professor of Food Science
Dietary polyphenols in prevention of obesity and fatty liver disease; efficacy and mechanisms of action of food-derived phytochemicals in prevention of lung cancer; biotransformation, bioavailability and potential hepatotoxicity of dietary phytochemicals
Professor of Veterinary & Biomedical Sciences; H. Thomas and Dorothy Willits Hallowell Chair; Emphasis Area Representative, Molecular Toxicology
Nuclear receptor biology and genomics. Xenobiotic Receptor systems that regulate biotransformation, detoxication, cancer predisposition, lipid and energy homeostasis.
Distinguished Professor of Molecular Toxicology and Carcinogenesis
Roles of peroxisome proliferator-activated receptors (PPARs) in the regulation of homeostasis, toxicology, and carcinogenesis.
Professor of Immunology and Molecular Toxicology
Molecular mechanisms by which bioactives such as selenium, omega-3 fatty acids, and other products of natural origin alter the host response and immune function in inflammation and cancer
Associate Director, Huck Institutes of the Life Sciences; Associate Professor; Broadhurst Career Development Professor for the Study of Health Promotion and Disease Prevention
Role of changes in energy balance and related nutritional factors on inflammation, immune regulation and cancer risk using both animal models and human subjects.
Director of the Center for Excellence in Nutrigenomics; Professor of Molecular Toxicology
Mechanisms of action of hypolipidemic drugs and peroxisome proliferators; steroid hormone receptor-mediated signal transduction; signal transduction by lipids and fatty acids; receptor-mediated carcinogenesis.