Adam Glick
Associate Chair, Molecular Cellular and Integrative Biosciences; Emphasis Area Representative, Cancer Biology; Professor of Molecular Toxicology and Carcinogenesis;
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306C Huck Life Sciences
University Park, PA - abg11@psu.edu
- 814-865-7170
Research Summary
The role of Transforming Growth Factor-beta in cutaneous inflammation and cancer development, and how the immune system responds to epithelial cells with activated oncogenes such as Ras. Signaling pathways that regulate senescence of premalignant epithelial cells and how cells escape from oncogene-induced senescence.
Huck Affiliations
- Center for Infectious Disease Dynamics
- Molecular, Cellular, and Integrative Biosciences
- Center for Molecular Toxicology and Carcinogenesis
Links
Publication Tags
Keratinocytes Skin Proteins Neoplasms Gene Expression Peptides Aryl Hydrocarbon Receptors Masks Protein Transforming Growth Factor Beta Endoplasmic Reticulum Stress Genes Apoptosis Unfolded Protein Response Inositol Enzymes Hydrocarbon Nanoparticles Drug Delivery Systems Delivery Tumors Cells Cell Death Endoplasmic Reticulum HomeostasisMost Recent Publications
The unfolded protein response gene Ire1α is required for tissue renewal and normal differentiation in the mouse tongue and esophagus
Fiona E. Chalmers, Saie Mogre, Bipin Rimal, Jeongin Son, Andrew D. Patterson, Douglas B. Stairs, Adam B. Glick, 2022, Developmental Biology on p. 59-70
TGFβ1 regulates HRas-mediated activation of IRE1α through the PERK-RPAP2 axis in keratinocytes
Saie Mogre, Nicholas Blazanin, Hailey Walsh, Jack Ibinson, Chase Minnich, Chih Chi Andrew Hu, Adam B. Glick, 2022, Molecular Carcinogenesis on p. 958-971
Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells
Nick A. Alden, Julien H. Arrizabalaga, Yiming Liu, Shantu Amin, Krishne Gowda, Shun Yao, Marco Archetti, Adam B. Glick, Daniel J. Hayes, 2022, Langmuir on p. 9833-9843
The Endoplasmic Reticulum Stress Sensor IRE1α Regulates the UV DNA Repair Response through the Control of Intracellular Calcium Homeostasis
Jeongin Son, Saie Mogre, Fiona E. Chalmers, Jack Ibinson, Stephen Worrell, Adam B. Glick, 2022, Journal of Investigative Dermatology on p. 1682-1691.e7
Targeted deletion of TGFβ1 in basal keratinocytes causes profound defects in stratified squamous epithelia and aberrant melanocyte migration
Fiona E. Chalmers, Justyn E. Dusold, Javed A. Shaik, Hailey A. Walsh, Adam B. Glick, 2022, Developmental Biology on p. 9-23
Photocontrolled miR-148b nanoparticles cause apoptosis, inflammation and regression of Ras induced epidermal squamous cell carcinomas in mice
Yiming Liu, Jacob T. Bailey, Mohammad Abu-Laban, Shue Li, Cong Chen, Adam B. Glick, Daniel J. Hayes, 2020, Biomaterials
Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers
Matthew Aronson^, Matthew R. Aronson, Erika Dahl, Jacob Halle^, Jacob A. Halle, Andrew W. Simonson, Andrew Simonson^, Rose Gogal, Adam B. Glick, Katherine M. Aird, Scott H. Medina, 2020, Cellular and Molecular Bioengineering on p. 447-461
Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks
Janna Sloand, Janna Sloand^, Eric Cook, Theodore Nguyen, Scott A. Zinck, Tawanda Zimudzi, Erik C. Cook, Scott Zinck, S Showalter, Tawanda J. Zimudzi, Scott Schowalter, Scott A. Showalter, Julianna Simon, S Medina, Adam B. Glick, Julianna Simon, Scott Medina*, 2020, ACS Nano on p. 4061-4073
The multiple roles of the unfolded protein response regulator IRE1α in cancer
Fiona Chalmers, Saie Mogre, Jeongin Son, Nicholas Blazanin, Adam B. Glick, 2019, Molecular Carcinogenesis on p. 1623-1630
Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin
K Smith, J Boyer, G Muku, I Murray, Krishne Gowda, D Desai, S Amin, A Glick, G Perdew, 2017, Toxicological Sciences on p. 83-94
Most-Cited Papers
Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation
Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Joost Schalkwijk, Gary H. Perdew, Adam B. Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328
ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras
Nicholas Blazanin, Jeongin Son, Alayna B. Craig-Lucas, Christian L. John, Kyle J. Breech, Michael A. Podolsky, Adam B. Glick, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. 9900-9905
The nuclear receptor peroxisome proliferator-activated receptor-β/ δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress
Bokai Zhu, Christina H. Ferry, Lauren K. Markell, Nicholas Blazanin, Adam B. Glick, Frank J. Gonzalez, Jeffrey M. Peters, 2014, Journal of Biological Chemistry on p. 20102-20119
PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling
B. Zhu, C. H. Ferry, N. Blazanin, M. T. Bility, C. Khozoie, B. H. Kang, A. B. Glick, F. J. Gonzalez, J. M. Peters, 2014, Oncogene on p. 5348-5359
Conditional expression of TGF-β1 in skeletal muscles causes endomysial fibrosis and myofibers atrophy
Jigna Narola, Sachchida Nand Pandey, Adam Glick, Yi Wen Chen, 2013, PLoS One
CD8<sup>+</sup> T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ
Andrew J. Gunderson, Javed Mohammed, Frank J. Horvath, Michael A. Podolsky, Cherie R. Anderson, Adam B. Glick, 2013, Journal of Investigative Dermatology on p. 955-963
The TGFβ1 pathway is required for NFκB dependent gene expression in mouse keratinocytes
Kelly A. Hogan, Anand Ravindran, Michael A. Podolsky, Adam B. Glick, 2013, Cytokine on p. 652-659
Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin
K Smith, J Boyer, G Muku, I Murray, Krishne Gowda, D Desai, S Amin, A Glick, G Perdew, 2017, Toxicological Sciences on p. 83-94
TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity
Javed Mohammed, Andrew J. Gunderson, Hong Hanh Khong, Richard D. Koubek, Mark C. Udey, Adam B. Glick, 2013, Journal of Investigative Dermatology on p. 135-143
Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks
Janna Sloand, Janna Sloand^, Eric Cook, Theodore Nguyen, Scott A. Zinck, Tawanda Zimudzi, Erik C. Cook, Scott Zinck, S Showalter, Tawanda J. Zimudzi, Scott Schowalter, Scott A. Showalter, Julianna Simon, S Medina, Adam B. Glick, Julianna Simon, Scott Medina*, 2020, ACS Nano on p. 4061-4073