Adam Glick

Associate Chair, Molecular Cellular and Integrative Biosciences; Emphasis Area Representative, Cancer Biology; Professor of Molecular Toxicology and Carcinogenesis;

Adam Glick

Research Summary

The role of Transforming Growth Factor-beta in cutaneous inflammation and cancer development, and how the immune system responds to epithelial cells with activated oncogenes such as Ras. Signaling pathways that regulate senescence of premalignant epithelial cells and how cells escape from oncogene-induced senescence.

Graduate Students

Huck Affiliations

Links

Publication Tags

Skin Keratinocytes Neoplasms Aryl Hydrocarbon Receptors Transforming Growth Factors Inflammation Carcinogenesis Langerhans Cells Fibrosis Interleukin 17 Endoplasmic Reticulum Stress Pharmacology Ligands Lymph Nodes Atrophy Muscles Chemotactic Factors Enzymes Skeletal Muscle Inositol Cytoplasmic And Nuclear Receptors Transforming Growth Factor Beta T Lymphocytes Proteins 4 (5 Benzo(1,3)Dioxol 5 Yl 4 Pyridin 2 Yl 1h Imidazol 2 Yl)Benza

Most Recent Papers

Photocontrolled miR-148b nanoparticles cause apoptosis, inflammation and regression of Ras induced epidermal squamous cell carcinomas in mice.

Y Liu, J Bailey, M Abu-Laban, S Li, C Chen, Adam Glick, D Hayes, 2020, Biomaterials on p. 120212

Ultrasound-Guided Cytosolic Protein Delivery <i>via</i> Transient Fluorous Masks.

J Sloand, Toan Nguyen, S Zinck, E Cook, T Zimudzi, Scott Showalter, Adam Glick, Julianna Simon, Scott Medina, 2020, ACS nano on p. 4061-4073

Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers

Matthew Aronson, Erika Dahl, Jacob Halle, Andrew Simonson, Rose Gogal, Adam Glick, Katherine Aird, Scott Medina, 2020, Cellular and Molecular Bioengineering on p. 1--15

The multiple roles of the unfolded protein response regulator IRE1α in cancer

Fiona Chalmers, Saie Mogre, Jeongin Son, Nicholas Blazanin, Adam Bleier Glick, 2019, Molecular Carcinogenesis on p. 1623-1630

ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras

Nicholas Blazanin, Jeongin Son, Alayna B. Craig-Lucas, Christian L. John, Kyle J. Breech, Michael A. Podolsky, Adam B. Glick, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. 9900-9905

Estrogen modulates mesenchyme-epidermis interactions in the adult nipple

Hsing Jung Wu, Ji Won Oh, Dan F. Spandau, Sunil Tholpady, Jesus Diaz, Laura J. Schroeder, Carlos D. Offutt, Adam B. Glick, Maksim V. Plikus, Sachiko Koyama, John Foley, 2017, Development (Cambridge) on p. 1498-1509

Differentiated state of initiating tumor cells is key to distinctive immune responses seen in H-Ras<sup>G12V</sup>-induced squamous tumors

Michael A. Podolsky, Jacob T. Bailey, Andrew J. Gunderson, Carrie J. Oakes, Kyle Breech, Adam B. Glick, 2017, Cancer Immunology Research on p. 198-210

Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin

Kayla J. Smith, Jacob A. Boyer, Gulsum E. Muku, Iain A. Murray, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Adam B. Glick, Gary H. Perdew, 2017, Toxicological Sciences on p. 83-94

Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation

Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Joost Schalkwijk, Gary H. Perdew, Adam B. Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328

Tumor-promoting role of TGFß1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells

Anand Ravindran, Javed Mohammed, Andrew J. Gunderson, Xiao Cui, Adam B. Glick, 2014, Carcinogenesis on p. 959-966

Most-Cited Papers

Tubular overexpression of transforming growth factor-β1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells

Robert Koesters, Brigitte Kaissling, Michel LeHir, Nicolas Picard, Franziska Theilig, Rolf Gebhardt, Adam B. Glick, Brunhilde Hähnel, Hiltraud Hosser, Hermann Josef Gröne, Wilhelm Kriz, 2010, American Journal of Pathology on p. 632-643

Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation

Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Joost Schalkwijk, Gary H. Perdew, Adam B. Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328

The nuclear receptor peroxisome proliferator-activated receptor-β/ δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress

Bokai Zhu, Christina H. Ferry, Lauren K. Markell, Nicholas Blazanin, Adam B. Glick, Frank J. Gonzalez, Jeffrey M. Peters, 2014, Journal of Biological Chemistry on p. 20102-20119

Conditional expression of TGF-β1 in skeletal muscles causes endomysial fibrosis and myofibers atrophy

Jigna Narola, Sachchida Nand Pandey, Adam Glick, Yi Wen Chen, 2013, PloS one

CD8<sup>+</sup> T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ

Andrew J. Gunderson, Javed Mohammed, Frank J. Horvath, Michael A. Podolsky, Cherie R. Anderson, Adam B. Glick, 2013, Journal of Investigative Dermatology on p. 955-963

Use of a TGFβ type I receptor inhibitor in mouse skin carcinogenesis reveals a dual role for TGFβ signaling in tumor promotion and progression

Lauren Mordasky Markell, Rolando Pérez-Lorenzo, Katelyn E. Masiuk, Mary J. Kennett, Adam B. Glick, 2010, Carcinogenesis on p. 2127-2135

TGFΒ1-induced inflammation in premalignant epidermal squamous lesions requires IL-17

Javed Mohammed, Andrew Ryscavage, Rolando Perez-Lorenzo, Andrew J. Gunderson, Nicholas Blazanin, Adam Bleier Glick, 2010, Journal of Investigative Dermatology on p. 2295-2303

TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity

Javed Mohammed, Andrew J. Gunderson, Hong Hanh Khong, Richard D. Koubek, Mark C. Udey, Adam B. Glick, 2013, Journal of Investigative Dermatology on p. 135-143

Tumor-promoting role of TGFß1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells

Anand Ravindran, Javed Mohammed, Andrew J. Gunderson, Xiao Cui, Adam B. Glick, 2014, Carcinogenesis on p. 959-966

Transforming growth factor β1 enhances tumor promotion in mouse skin carcinogenesis

Rolando Pérez-Lorenzo, Lauren Mordasky Markell, Kelly A. Hogan, Stuart H. Yuspa, Adam Bleier Glick, 2010, Carcinogenesis on p. 1116-1123