Adam Glick
Associate Chair, Molecular Cellular and Integrative Biosciences; Emphasis Area Representative, Cancer Biology; Professor of Molecular Toxicology and Carcinogenesis;
- 306C Huck Life Sciences
University Park, PA - abg11@psu.edu
- 814-865-7170
Research Summary
The role of Transforming Growth Factor-beta in cutaneous inflammation and cancer development, and how the immune system responds to epithelial cells with activated oncogenes such as Ras. Signaling pathways that regulate senescence of premalignant epithelial cells and how cells escape from oncogene-induced senescence.
Graduate Students
Huck Institutes Affiliations
- Center for Infectious Disease Dynamics
- Molecular, Cellular, and Integrative Biosciences
- Center for Molecular Toxicology and Carcinogenesis
Links
Publication Tags
Skin Keratinocytes Aryl Hydrocarbon Receptors Neoplasms Fibrosis Muscles Atrophy Skeletal Muscle Cytoplasmic And Nuclear Receptors Phenotype Inflammation Oncogenes Endoplasmic Reticulum Stress Gene Expression Carcinogenesis T Lymphocytes Pharmacology Ligands Transforming Growth Factor Beta Proteins 4 (5 Benzo(1,3)Dioxol 5 Yl 4 Pyridin 2 Yl 1h Imidazol 2 Yl)Benza T Cells Muscle Dermatitis Peroxisome Proliferator Activated ReceptorsMost Recent Papers
ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras
Nicholas Blazanin, Jeongin Son, Alayna B. Craig-Lucas, Christian L. John, Kyle J. Breech, Michael A. Podolsky, Adam Bleier Glick, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. 9900-9905
Estrogen modulates mesenchyme-epidermis interactions in the adult nipple
Hsing Jung Wu, Ji Won Oh, Dan F. Spandau, Sunil Tholpady, Jesus Diaz, Laura J. Schroeder, Carlos D. Offutt, Adam Bleier Glick, Maksim V. Plikus, Sachiko Koyama, John Foley, 2017, Development (Cambridge) on p. 1498-1509
Differentiated state of initiating tumor cells is key to distinctive immune responses seen in H-Ras<sup>G12V</sup>-induced squamous tumors
Michael A. Podolsky, Jacob T. Bailey, Andrew J. Gunderson, Carrie J. Oakes, Kyle Breech, Adam Bleier Glick, 2017, Cancer Immunology Research on p. 198-210
Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin
Kayla J. Smith, Jacob A. Boyer, Gulsum E. Muku, Iain Alexander Murray, Krishne Gowda, Dhimant Desai, Shantu Amin, Adam Bleier Glick, Gary H. Perdew, 2017, Toxicological Sciences on p. 83-94
Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation
Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu Amin, Joost Schalkwijk, Gary H. Perdew, Adam Bleier Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328
The nuclear receptor peroxisome proliferator-activated receptor-β/ δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress
Bokai Zhu, Christina H. Ferry, Lauren K. Markell, Nicholas Blazanin, Adam Bleier Glick, Frank J. Gonzalez, Jeffrey Maurice Peters, 2014, Journal of Biological Chemistry on p. 20102-20119
Tumor-promoting role of TGFß1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells
Anand Ravindran, Javed Mohammed, Andrew J. Gunderson, Xiao Cui, Adam Bleier Glick, 2014, Carcinogenesis on p. 959-966
The TGFβ1 pathway is required for NFκB dependent gene expression in mouse keratinocytes
Kelly A. Hogan, Anand Ravindran, Michael A. Podolsky, Adam Bleier Glick, 2013, Cytokine on p. 652-659
Conditional expression of TGF-β1 in skeletal muscles causes endomysial fibrosis and myofibers atrophy
Jigna Narola, Sachchida Nand Pandey, Adam Bleier Glick, Yi Wen Chen, 2013, PloS one
CD8<sup>+</sup> T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ
Andrew J. Gunderson, Javed Mohammed, Frank J. Horvath, Michael A. Podolsky, Cherie R. Anderson, Adam Bleier Glick, 2013, Journal of Investigative Dermatology on p. 955-963
High-Impact Papers
Tubular overexpression of transforming growth factor-β1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells
Robert Koesters, Brigitte Kaissling, Michel LeHir, Nicolas Picard, Franziska Theilig, Rolf Gebhardt, Adam Bleier Glick, Brunhilde Hähnel, Hiltraud Hosser, Hermann Josef Gröne, Wilhelm Kriz, 2010, American Journal of Pathology on p. 632-643
Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodeling
Tao Zheng, Min H. Oh, Sun Y. Oh, John T. Schroeder, Adam Bleier Glick, Zhou Zhu, 2009, Journal of Investigative Dermatology on p. 742-751
Persistence of high-grade cervical dysplasia and cervical cancer requires the continuous expression of the human papillomavirus type 16 E7 oncogene
Sean F. Jabbar, Linda Abrams, Adam Bleier Glick, Paul F. Lambert, 2009, Cancer Research on p. 4407-4414
Induction of p16<sup>ink4a</sup> and p19<sup>ARF</sup> by TGFβ1 contributes to growth arrest and senescence response in mouse keratinocytes
Kinnimulki Vijayachandra, William Evan Higgins, Jessica Lee, Adam Bleier Glick, 2009, Molecular Carcinogenesis on p. 181-186
Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation
Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu Amin, Joost Schalkwijk, Gary H. Perdew, Adam Bleier Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328
The nuclear receptor peroxisome proliferator-activated receptor-β/ δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress
Bokai Zhu, Christina H. Ferry, Lauren K. Markell, Nicholas Blazanin, Adam Bleier Glick, Frank J. Gonzalez, Jeffrey Maurice Peters, 2014, Journal of Biological Chemistry on p. 20102-20119
CD8<sup>+</sup> T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ
Andrew J. Gunderson, Javed Mohammed, Frank J. Horvath, Michael A. Podolsky, Cherie R. Anderson, Adam Bleier Glick, 2013, Journal of Investigative Dermatology on p. 955-963
Conditional expression of TGF-β1 in skeletal muscles causes endomysial fibrosis and myofibers atrophy
Jigna Narola, Sachchida Nand Pandey, Adam Bleier Glick, Yi Wen Chen, 2013, PloS one
Use of a TGFβ type I receptor inhibitor in mouse skin carcinogenesis reveals a dual role for TGFβ signaling in tumor promotion and progression
Lauren Mordasky Markell, Rolando Pérez-Lorenzo, Katelyn E. Masiuk, Mary J. Kennett, Adam Bleier Glick, 2010, Carcinogenesis on p. 2127-2135
Inhibition of CREB function in mouse epidermis reduces papilloma formation
Julian Rozenberg, Vikas Rishi, Andras Orosz, Jaideep Moitra, Adam Bleier Glick, Charles Vinson, 2009, Molecular Cancer Research on p. 654-664