Adam Glick

Associate Chair, Molecular Cellular and Integrative Biosciences; Emphasis Area Representative, Cancer Biology; Professor of Molecular Toxicology and Carcinogenesis;

Adam Glick

Research Summary

Research in my lab focuses on the role of Transforming Growth Factor-beta in cutaneous inflammation and cancer development, and how the immune system responds to epithelial cells with activated oncogenes such as Ras. We are also interested in signaling pathways that regulate senescence of premalignant epithelial cells and how cells escape from oncogene-induced senescence.

Graduate Students

Huck Institutes Affiliations

Links

Most Recent Papers

ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras

Nicholas Blazanin, Jeongin Son, Alayna B. Craig-Lucas, Christian L. John, Kyle J. Breech, Michael A. Podolsky, Adam B. Glick, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. 9900-9905

Estrogen modulates mesenchyme-epidermis interactions in the adult nipple

Hsing Jung Wu, Ji Won Oh, Dan F. Spandau, Sunil Tholpady, Jesus Diaz, Laura J. Schroeder, Carlos D. Offutt, Adam B. Glick, Maksim V. Plikus, Sachiko Koyama, John Foley, 2017, Development (Cambridge) on p. 1498-1509

Differentiated state of initiating tumor cells is key to distinctive immune responses seen in H-Ras<sup>G12V</sup>-induced squamous tumors

Michael A. Podolsky, Jacob T. Bailey, Andrew J. Gunderson, Carrie J. Oakes, Kyle Breech, Adam B. Glick, 2017, Cancer Immunology Research on p. 198-210

Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin

Kayla J. Smith, Jacob A. Boyer, Gulsum E. Muku, Iain A. Murray, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Adam B. Glick, Gary H. Perdew, 2017, Toxicological Sciences on p. 83-94

Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation

Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Joost Schalkwijk, Gary H. Perdew, Adam B. Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328

The nuclear receptor peroxisome proliferator-activated receptor-β/ δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress

Bokai Zhu, Christina H. Ferry, Lauren K. Markell, Nicholas Blazanin, Adam B. Glick, Frank J. Gonzalez, Jeffrey M. Peters, 2014, Journal of Biological Chemistry on p. 20102-20119

Tumor-promoting role of TGFß1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells

Anand Ravindran, Javed Mohammed, Andrew J. Gunderson, Xiao Cui, Adam B. Glick, 2014, Carcinogenesis on p. 959-966

The TGFβ1 pathway is required for NFκB dependent gene expression in mouse keratinocytes

Kelly A. Hogan, Anand Ravindran, Michael A. Podolsky, Adam B. Glick, 2013, Cytokine on p. 652-659

Conditional expression of TGF-β1 in skeletal muscles causes endomysial fibrosis and myofibers atrophy

Jigna Narola, Sachchida Nand Pandey, Adam Glick, Yi Wen Chen, 2013, PLoS One

CD8<sup>+</sup> T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ

Andrew J. Gunderson, Javed Mohammed, Frank J. Horvath, Michael A. Podolsky, Cherie R. Anderson, Adam B. Glick, 2013, Journal of Investigative Dermatology on p. 955-963

High-Impact Papers

Tubular overexpression of transforming growth factor-β1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells

Robert Koesters, Brigitte Kaissling, Michel LeHir, Nicolas Picard, Franziska Theilig, Rolf Gebhardt, Adam B. Glick, Brunhilde Hähnel, Hiltraud Hosser, Hermann Josef Gröne, Wilhelm Kriz, 2010, American Journal of Pathology on p. 632-643

Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodeling

Tao Zheng, Min H. Oh, Sun Y. Oh, John T. Schroeder, Adam B. Glick, Zhou Zhu, 2009, Journal of Investigative Dermatology on p. 742-751

Persistence of high-grade cervical dysplasia and cervical cancer requires the continuous expression of the human papillomavirus type 16 E7 oncogene

Sean F. Jabbar, Linda Abrams, Adam Glick, Paul F. Lambert, 2009, Cancer Research on p. 4407-4414

Induction of p16<sup>ink4a</sup> and p19<sup>ARF</sup> by TGFβ1 contributes to growth arrest and senescence response in mouse keratinocytes

Kinnimulki Vijayachandra, William Higgins, Jessica Lee, Adam Glick, 2009, Molecular Carcinogenesis on p. 181-186

The nuclear receptor peroxisome proliferator-activated receptor-β/ δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress

Bokai Zhu, Christina H. Ferry, Lauren K. Markell, Nicholas Blazanin, Adam B. Glick, Frank J. Gonzalez, Jeffrey M. Peters, 2014, Journal of Biological Chemistry on p. 20102-20119

CD8<sup>+</sup> T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ

Andrew J. Gunderson, Javed Mohammed, Frank J. Horvath, Michael A. Podolsky, Cherie R. Anderson, Adam B. Glick, 2013, Journal of Investigative Dermatology on p. 955-963

Conditional expression of TGF-β1 in skeletal muscles causes endomysial fibrosis and myofibers atrophy

Jigna Narola, Sachchida Nand Pandey, Adam Glick, Yi Wen Chen, 2013, PLoS One

Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation

Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Joost Schalkwijk, Gary H. Perdew, Adam B. Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328

Inhibition of CREB function in mouse epidermis reduces papilloma formation

Julian Rozenberg, Vikas Rishi, Andras Orosz, Jaideep Moitra, Adam Glick, Charles Vinson, 2009, Molecular Cancer Research on p. 654-664

TGFΒ1-induced inflammation in premalignant epidermal squamous lesions requires IL-17

Javed Mohammed, Andrew Ryscavage, Rolando Perez-Lorenzo, Andrew J. Gunderson, Nicholas Blazanin, Adam B. Glick, 2010, Journal of Investigative Dermatology on p. 2295-2303