Adam Glick

Associate Chair, Molecular Cellular and Integrative Biosciences; Emphasis Area Representative, Cancer Biology; Professor of Molecular Toxicology and Carcinogenesis;

Adam Glick

Research Summary

The role of Transforming Growth Factor-beta in cutaneous inflammation and cancer development, and how the immune system responds to epithelial cells with activated oncogenes such as Ras. Signaling pathways that regulate senescence of premalignant epithelial cells and how cells escape from oncogene-induced senescence.

Huck Affiliations

Links

Publication Tags

Keratinocytes Skin Neoplasms Endoplasmic Reticulum Stress Aryl Hydrocarbon Receptors Transforming Growth Factor Beta Inflammation Enzymes Hydrocarbon Inositol Nanoparticles Ribonucleases Apoptosis Tumors Gene Expression Homeostasis Ligands Epithelial Cells Unfolded Protein Response Ligand Fibrosis Atrophy Chemotactic Factors Cytoplasmic And Nuclear Receptors Muscles

Most Recent Publications

TGFβ1 regulates HRas-mediated activation of IRE1α through the PERK-RPAP2 axis in keratinocytes

Saie Mogre, Nicholas Blazanin, Hailey Walsh, Jack Ibinson, Chase Minnich, Chih Chi Andrew Hu, Adam B. Glick, 2022, Molecular Carcinogenesis on p. 958-971

Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells

Nick A. Alden, Julien H. Arrizabalaga, Yiming Liu, Shantu Amin, Krishne Gowda, Shun Yao, Marco Archetti, Adam B. Glick, Daniel J. Hayes, 2022, Langmuir on p. 9833-9843

The Endoplasmic Reticulum Stress Sensor IRE1α Regulates the UV DNA Repair Response through the Control of Intracellular Calcium Homeostasis

Jeongin Son, Saie Mogre, Fiona E. Chalmers, Jack Ibinson, Stephen Worrell, Adam B. Glick, 2022, Journal of Investigative Dermatology on p. 1682-1691.e7

Targeted deletion of TGFβ1 in basal keratinocytes causes profound defects in stratified squamous epithelia and aberrant melanocyte migration

Fiona E. Chalmers, Justyn E. Dusold, Javed A. Shaik, Hailey A. Walsh, Adam B. Glick, 2022, Developmental Biology on p. 9-23

Photocontrolled miR-148b nanoparticles cause apoptosis, inflammation and regression of Ras induced epidermal squamous cell carcinomas in mice

Yiming Liu, Jacob T. Bailey, Mohammad Abu-Laban, Shue Li, Cong Chen, Adam B. Glick, Daniel J. Hayes, 2020, Biomaterials

The multiple roles of the unfolded protein response regulator IRE1α in cancer

Fiona Chalmers, Saie Mogre, Jeongin Son, Nicholas Blazanin, Adam B. Glick, 2019, Molecular Carcinogenesis on p. 1623-1630

Editor's Highlight: Ah Receptor Activation Potentiates Neutrophil Chemoattractant (C-X-C Motif) Ligand 5 Expression in Keratinocytes and Skin.

K Smith, J Boyer, G Muku, I Murray, Krishne Gowda, D Desai, S Amin, A Glick, G Perdew, 2017, Toxicological Sciences on p. 83-94

ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras

Nicholas Blazanin, Jeongin Son, Alayna B. Craig-Lucas, Christian L. John, Kyle J. Breech, Michael A. Podolsky, Adam B. Glick, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. 9900-9905

Estrogen modulates mesenchyme-epidermis interactions in the adult nipple

Hsing Jung Wu, Ji Won Oh, Dan F. Spandau, Sunil Tholpady, Jesus Diaz, Laura J. Schroeder, Carlos D. Offutt, Adam B. Glick, Maksim V. Plikus, Sachiko Koyama, John Foley, 2017, Journal of Embryology and Experimental Morphology on p. 1498-1509

Differentiated state of initiating tumor cells is key to distinctive immune responses seen in H-Ras<sup>G12V</sup>-induced squamous tumors

Michael A. Podolsky, Jacob T. Bailey, Andrew J. Gunderson, Carrie J. Oakes, Kyle Breech, Adam B. Glick, 2017, Cancer immunology research on p. 198-210

Most-Cited Papers

Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation

Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Joost Schalkwijk, Gary H. Perdew, Adam B. Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328

PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling

B. Zhu, C. H. Ferry, N. Blazanin, M. T. Bility, C. Khozoie, B. H. Kang, A. B. Glick, F. J. Gonzalez, J. M. Peters, 2014, Oncogene on p. 5348-5359

The nuclear receptor peroxisome proliferator-activated receptor-β/ δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress

Bokai Zhu, Christina H. Ferry, Lauren K. Markell, Nicholas Blazanin, Adam B. Glick, Frank J. Gonzalez, Jeffrey M. Peters, 2014, Journal of Biological Chemistry on p. 20102-20119

ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras

Nicholas Blazanin, Jeongin Son, Alayna B. Craig-Lucas, Christian L. John, Kyle J. Breech, Michael A. Podolsky, Adam B. Glick, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. 9900-9905

Conditional expression of TGF-β1 in skeletal muscles causes endomysial fibrosis and myofibers atrophy

Jigna Narola, Sachchida Nand Pandey, Adam Glick, Yi Wen Chen, 2013, PLoS One

CD8<sup>+</sup> T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ

Andrew J. Gunderson, Javed Mohammed, Frank J. Horvath, Michael A. Podolsky, Cherie R. Anderson, Adam B. Glick, 2013, Journal of Investigative Dermatology on p. 955-963

The TGFβ1 pathway is required for NFκB dependent gene expression in mouse keratinocytes.

Kelly A. Hogan, Anand Ravindran, Michael A. Podolsky, Adam B. Glick, 2013, Cytokine on p. 652-659

Editor's Highlight: Ah Receptor Activation Potentiates Neutrophil Chemoattractant (C-X-C Motif) Ligand 5 Expression in Keratinocytes and Skin.

K Smith, J Boyer, G Muku, I Murray, Krishne Gowda, D Desai, S Amin, A Glick, G Perdew, 2017, Toxicological Sciences on p. 83-94

TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity

Javed Mohammed, Andrew J. Gunderson, Hong Hanh Khong, Richard D. Koubek, Mark C. Udey, Adam B. Glick, 2013, Journal of Investigative Dermatology on p. 135-143

Tumor-promoting role of TGFß1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells

Anand Ravindran, Javed Mohammed, Andrew J. Gunderson, Xiao Cui, Adam B. Glick, 2014, Carcinogenesis on p. 959-966