Adam Glick
Associate Chair, Molecular Cellular and Integrative Biosciences; Emphasis Area Representative, Cancer Biology; Professor of Molecular Toxicology and Carcinogenesis;
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306C Huck Life Sciences
University Park, PA - abg11@psu.edu
- 814-865-7170
Research Summary
The role of Transforming Growth Factor-beta in cutaneous inflammation and cancer development, and how the immune system responds to epithelial cells with activated oncogenes such as Ras. Signaling pathways that regulate senescence of premalignant epithelial cells and how cells escape from oncogene-induced senescence.
Huck Graduate Students
Huck Affiliations
- Center for Infectious Disease Dynamics
- Molecular, Cellular, and Integrative Biosciences
- Center for Molecular Toxicology and Carcinogenesis
Links
Publication Tags
Keratinocytes Skin Aryl Hydrocarbon Receptors Neoplasms Ligands Endoplasmic Reticulum Stress Inflammation Cytoplasmic And Nuclear Receptors Chemotactic Factors Peptides Tumors Nanoparticles Inositol Langerhans Cells Ppar Delta Drug Delivery Systems Enzymes Peroxisome Proliferator Activated Receptors Transforming Growth Factor Beta Carcinogenesis Gene Expression Pharmacology Chemical Activation Ribonucleases Lymph NodesMost Recent Papers
Photocontrolled miR-148b nanoparticles cause apoptosis, inflammation and regression of Ras induced epidermal squamous cell carcinomas in mice
Yiming Liu, Jacob T. Bailey, Mohammad Abu-Laban, Shue Li, Cong Chen, Adam B. Glick, Daniel J. Hayes, 2020, Biomaterials
Re-engineering antimicrobial peptides into oncolytics targeting drug-resistant ovarian cancers
Matthew R. Aronson, Erika S. Dahl, Jacob A. Halle, Andrew W. Simonson, Rose A. Gogal, Adam B. Glick, Katherine M. Aird, Scott H. Medina, 2020, Cellular and Molecular Bioengineering on p. 447-461
The multiple roles of the unfolded protein response regulator IRE1α in cancer
Fiona Chalmers, Saie Mogre, Jeongin Son, Nicholas Blazanin, Adam Bleier Glick, 2019, Molecular Carcinogenesis on p. 1623-1630
ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras
Nicholas Blazanin, Jeongin Son, Alayna B. Craig-Lucas, Christian L. John, Kyle J. Breech, Michael A. Podolsky, Adam B. Glick, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. 9900-9905
Estrogen modulates mesenchyme-epidermis interactions in the adult nipple
Hsing Jung Wu, Ji Won Oh, Dan F. Spandau, Sunil Tholpady, Jesus Diaz, Laura J. Schroeder, Carlos D. Offutt, Adam B. Glick, Maksim V. Plikus, Sachiko Koyama, John Foley, 2017, Development (Cambridge) on p. 1498-1509
Differentiated state of initiating tumor cells is key to distinctive immune responses seen in H-Ras<sup>G12V</sup>-induced squamous tumors
Michael A. Podolsky, Jacob T. Bailey, Andrew J. Gunderson, Carrie J. Oakes, Kyle Breech, Adam B. Glick, 2017, Cancer immunology research on p. 198-210
Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin
Kayla J. Smith, Jacob A. Boyer, Gulsum E. Muku, Iain A. Murray, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Adam B. Glick, Gary H. Perdew, 2017, Toxicological Sciences on p. 83-94
Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation
Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Joost Schalkwijk, Gary H. Perdew, Adam B. Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328
Tumor-promoting role of TGFß1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells
Anand Ravindran, Javed Mohammed, Andrew J. Gunderson, Xiao Cui, Adam B. Glick, 2014, Carcinogenesis on p. 959-966
The nuclear receptor peroxisome proliferator-activated receptor-β/ δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress
Bokai Zhu, Christina H. Ferry, Lauren K. Markell, Nicholas Blazanin, Adam B. Glick, Frank J. Gonzalez, Jeffrey M. Peters, 2014, Journal of Biological Chemistry on p. 20102-20119
Most-Cited Papers
Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation
Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Joost Schalkwijk, Gary H. Perdew, Adam B. Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328
The nuclear receptor peroxisome proliferator-activated receptor-β/ δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress
Bokai Zhu, Christina H. Ferry, Lauren K. Markell, Nicholas Blazanin, Adam B. Glick, Frank J. Gonzalez, Jeffrey M. Peters, 2014, Journal of Biological Chemistry on p. 20102-20119
Conditional expression of TGF-β1 in skeletal muscles causes endomysial fibrosis and myofibers atrophy
Jigna Narola, Sachchida Nand Pandey, Adam Glick, Yi Wen Chen, 2013, PLoS One
CD8<sup>+</sup> T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ
Andrew J. Gunderson, Javed Mohammed, Frank J. Horvath, Michael A. Podolsky, Cherie R. Anderson, Adam B. Glick, 2013, Journal of Investigative Dermatology on p. 955-963
The TGFβ1 pathway is required for NFκB dependent gene expression in mouse keratinocytes.
K Hogan, Arunachalam Ravindran, M Podolsky, Adam Glick, 2013, Cytokine on p. 652-659
ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras
Nicholas Blazanin, Jeongin Son, Alayna B. Craig-Lucas, Christian L. John, Kyle J. Breech, Michael A. Podolsky, Adam B. Glick, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. 9900-9905
TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity
Javed Mohammed, Andrew J. Gunderson, Hong Hanh Khong, Richard D. Koubek, Mark C. Udey, Adam B. Glick, 2013, Journal of Investigative Dermatology on p. 135-143
Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin
Kayla J. Smith, Jacob A. Boyer, Gulsum E. Muku, Iain A. Murray, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Adam B. Glick, Gary H. Perdew, 2017, Toxicological Sciences on p. 83-94
Tumor-promoting role of TGFß1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells
Anand Ravindran, Javed Mohammed, Andrew J. Gunderson, Xiao Cui, Adam B. Glick, 2014, Carcinogenesis on p. 959-966
Peroxisome proliferator-activated receptor β/δ cross talks with e2f and attenuates mitosis in HRAS-expressing cells
Bokai Zhu, Combiz Khozoie, Moses T. Bility, Christina H. Ferry, Nicholas Blazanin, Adam B. Glick, Frank J. Gonzalez, Jeffrey M. Peters, 2012, Molecular and Cellular Biology on p. 2065-2082