Joshua Kellogg
Emphasis Area Representative, Molecular Toxicology; Assistant Professor of Veterinary and Biomedical Sciences

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325 Huck Life Sciences
University Park, PA - jjk6146@psu.edu
- 814-865-2887
Research Summary
Development of new metabolomics tools for chemical and biological characterization of complex systems. Discovery of new natural products from plants and microorganisms with novel bioactivity against pathogenic fungi and neglected tropical diseases. Bioanalytical techniques to probe the mechanism of action and basic biology of these target organisms. Ethnobotany and indigenous knowledge surrounding plant-based medicine.
Huck Graduate Students
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- Plant Institute
- Plant Biology
- Microbiome Center
- Center for Chemical Ecology
- Integrative and Biomedical Physiology
Links
Publication Tags
Metabolomics Biological Products Mass Spectrometry Indole Alkaloids Oxindoles Mitragyna Hydrastis Oxides In Vitro Techniques Occurrence In Nature Mitragynine Liquid Chromatography Alkaloids Metabolites Dietary Supplements Drug Interactions Datasets Principal Component Analysis Fungi Fractionation Industry Alkaloid Metabolite Complex Mixtures Indole AlkaloidMost Recent Publications
Untargeted metabolomics for the study of antiinfective plants
Joshua J. Kellogg, 2022, on p. 335-359
Chemometric-Guided Approaches for Profiling and Authenticating Botanical Materials
Evelyn J. Abraham, Joshua J. Kellogg, 2021, Frontiers in Nutrition
Assessing Transporter-Mediated Natural Product-Drug Interactions Via In vitro-In Vivo Extrapolation: Clinical Evaluation With a Probe Cocktail
James T. Nguyen, Dan Dan Tian, Rakshit S. Tanna, Deena L. Hadi, Sumit Bansal, Justina C. Calamia, Christopher M. Arian, Laura M. Shireman, Bálint Molnár, Miklós Horváth, Joshua J. Kellogg, Matthew E. Layton, John R. White, Nadja B. Cech, Richard D. Boyce, Jashvant D. Unadkat, Kenneth E. Thummel, Mary F. Paine, 2021, Clinical Pharmacology and Therapeutics on p. 1342-1352
Interlaboratory Comparison of Untargeted Mass Spectrometry Data Uncovers Underlying Causes for Variability
Trevor N. Clark, Joëlle Houriet, Warren S. Vidar, Joshua J. Kellogg, Daniel A. Todd, Nadja B. Cech, Roger G. Linington, 2021, Journal of Natural Products on p. 824-835
Quantification for non-targeted LC/MS screening without standard substances
Jaanus Liigand, Tingting Wang, Joshua Kellogg, Jørn Smedsgaard, Nadja Cech, Anneli Kruve, 2020, Scientific Reports
Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions
D. A. Todd, J. J. Kellogg, E. D. Wallace, M. Khin, L. Flores-Bocanegra, R. S. Tanna, S. McIntosh, H. A. Raja, T. N. Graf, S. E. Hemby, M. F. Paine, N. H. Oberlies, N. B. Cech, 2020, Scientific Reports
Assessing Transporter-Mediated Natural Product-Drug Interactions Via In vitro-In Vivo Extrapolation: Clinical Evaluation With a Probe Cocktail
James Nguyen, Dan-Dan Tian, Rakshit Tanna, Deena Hadi, Sumit Bansal, Justina Calamia, Christopher Arian, Shireman, Balint Molnar, Miklos Horvath, Josh Kellogg, Matthew Layton, John White, Nadja Cech, Richard Boyce, Jashvant Unadkat, Kenneth Thummel, Mary Paine, 2020, Clinical Pharmacology & Therapeutics on p. 1342-1352
The Chemistry of Kratom [ Mitragyna speciosa]: Updated Characterization Data and Methods to Elucidate Indole and Oxindole Alkaloids
Laura Flores-Bocanegra, Huzefa A. Raja, Tyler N. Graf, Mario Augustinović, E. Diane Wallace, Shabnam Hematian, Joshua J. Kellogg, Daniel A. Todd, Nadja B. Cech, Nicholas H. Oberlies, 2020, Journal of Natural Products on p. 2165-2177
Identification of adulteration in botanical samples with untargeted metabolomics
E. Diane Wallace, Daniel A. Todd, James M. Harnly, Nadja B. Cech, Joshua J. Kellogg, 2020, Fresenius Zeitschrift fur Analytische Chemie on p. 4273-4286
Chemical evaluation of the effects of storage conditions on the botanical goldenseal using marker-based and metabolomics approaches
Manead Khin, Nadja B. Cech, Joshua J. Kellogg, Lindsay K. Caesar, 2020, Yale Journal of Biology and Medicine on p. 265-275
Most-Cited Papers
Biochemometrics for Natural Products Research: Comparison of Data Analysis Approaches and Application to Identification of Bioactive Compounds
Joshua J. Kellogg, Daniel A. Todd, Joseph M. Egan, Huzefa A. Raja, Nicholas H. Oberlies, Olav M. Kvalheim, Nadja B. Cech, 2016, Journal of Natural Products on p. 376-386
Endolichenic fungi: a new source of rich bioactive secondary metabolites on the horizon
Joshua J. Kellogg, Huzefa A. Raja, 2017, Phytochemistry Reviews on p. 271-293
Phlorotannins from alaskan seaweed inhibit carbolytic enzyme activity
Joshua Kellogg, Mary H. Grace, Mary Ann Lila, 2014, Marine Drugs on p. 5277-5294
Selection and characterization of botanical natural products for research studies: A NaPDI center recommended approach
Joshua J. Kellogg, Mary F. Paine, Jeannine S. McCune, Nicholas H. Oberlies, Nadja B. Cech, 2019, Natural Product Reports on p. 1196-1221
Biochemometrics to Identify Synergists and Additives from Botanical Medicines: A Case Study with Hydrastis canadensis (Goldenseal)
Emily R. Britton, Joshua J. Kellogg, Olav M. Kvalheim, Nadja B. Cech, 2018, Journal of Natural Products on p. 484-493
Quantification for non-targeted LC/MS screening without standard substances
Jaanus Liigand, Tingting Wang, Joshua Kellogg, Jørn Smedsgaard, Nadja Cech, Anneli Kruve, 2020, Scientific Reports
Comparison of Metabolomics Approaches for Evaluating the Variability of Complex Botanical Preparations: Green Tea (Camellia sinensis) as a Case Study
Joshua J. Kellogg, Tyler N. Graf, Mary F. Paine, Jeannine S. McCune, Olav M. Kvalheim, Nicholas H. Oberlies, Nadja B. Cech, 2017, Journal of Natural Products on p. 1457-1466
Opportunities and Limitations for Untargeted Mass Spectrometry Metabolomics to Identify Biologically Active Constituents in Complex Natural Product Mixtures
Lindsay K. Caesar, Joshua J. Kellogg, Olav M. Kvalheim, Nadja B. Cech, 2019, Journal of Natural Products on p. 469-484
Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions
D. A. Todd, J. J. Kellogg, E. D. Wallace, M. Khin, L. Flores-Bocanegra, R. S. Tanna, S. McIntosh, H. A. Raja, T. N. Graf, S. E. Hemby, M. F. Paine, N. H. Oberlies, N. B. Cech, 2020, Scientific Reports
The Chemistry of Kratom [ Mitragyna speciosa]: Updated Characterization Data and Methods to Elucidate Indole and Oxindole Alkaloids
Laura Flores-Bocanegra, Huzefa A. Raja, Tyler N. Graf, Mario Augustinović, E. Diane Wallace, Shabnam Hematian, Joshua J. Kellogg, Daniel A. Todd, Nadja B. Cech, Nicholas H. Oberlies, 2020, Journal of Natural Products on p. 2165-2177