Joshua Kellogg

Emphasis Area Representative, Molecular Toxicology; Assistant Professor of Veterinary and Biomedical Sciences

325 Huck Life Sciences
University Park, PA
jjk6146@psu.edu
814-865-2887

Bio & Links
Publications

Research Summary

Development of new metabolomics tools for chemical and biological characterization of complex systems. Discovery of new natural products from plants and microorganisms with novel bioactivity against pathogenic fungi and neglected tropical diseases. Bioanalytical techniques to probe the mechanism of action and basic biology of these target organisms. Ethnobotany and indigenous knowledge surrounding plant-based medicine.

Huck Graduate Students

Huck Affiliations

Molecular, Cellular, and Integrative Biosciences

Plant Institute

Plant Biology

Microbiome Center

Center for Chemical Ecology

Integrative and Biomedical Physiology

Publication Tags

Metabolomics Biological Products Mass Spectrometry Indole Alkaloids Oxindoles Mitragyna Hydrastis Oxides In Vitro Techniques Occurrence In Nature Mitragynine Liquid Chromatography Alkaloids Metabolites Dietary Supplements Drug Interactions Datasets Principal Component Analysis Fungi Fractionation Industry Alkaloid Metabolite Complex Mixtures Indole Alkaloid

Most Recent Publications

Untargeted metabolomics for the study of antiinfective plants

Joshua J. Kellogg, 2022, on p. 335-359

Chemometric-Guided Approaches for Profiling and Authenticating Botanical Materials

Evelyn J. Abraham, Joshua J. Kellogg, 2021, Frontiers in Nutrition

Assessing Transporter-Mediated Natural Product-Drug Interactions Via In vitro-In Vivo Extrapolation: Clinical Evaluation With a Probe Cocktail

James T. Nguyen, Dan Dan Tian, Rakshit S. Tanna, Deena L. Hadi, Sumit Bansal, Justina C. Calamia, Christopher M. Arian, Laura M. Shireman, Bálint Molnár, Miklós Horváth, Joshua J. Kellogg, Matthew E. Layton, John R. White, Nadja B. Cech, Richard D. Boyce, Jashvant D. Unadkat, Kenneth E. Thummel, Mary F. Paine, 2021, Clinical Pharmacology and Therapeutics on p. 1342-1352

Interlaboratory Comparison of Untargeted Mass Spectrometry Data Uncovers Underlying Causes for Variability

Trevor N. Clark, Joëlle Houriet, Warren S. Vidar, Joshua J. Kellogg, Daniel A. Todd, Nadja B. Cech, Roger G. Linington, 2021, Journal of Natural Products on p. 824-835

Quantification for non-targeted LC/MS screening without standard substances

Jaanus Liigand, Tingting Wang, Joshua Kellogg, Jørn Smedsgaard, Nadja Cech, Anneli Kruve, 2020, Scientific Reports

Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions

D. A. Todd, J. J. Kellogg, E. D. Wallace, M. Khin, L. Flores-Bocanegra, R. S. Tanna, S. McIntosh, H. A. Raja, T. N. Graf, S. E. Hemby, M. F. Paine, N. H. Oberlies, N. B. Cech, 2020, Scientific Reports

Assessing Transporter-Mediated Natural Product-Drug Interactions Via In vitro-In Vivo Extrapolation: Clinical Evaluation With a Probe Cocktail

James Nguyen, Dan-Dan Tian, Rakshit Tanna, Deena Hadi, Sumit Bansal, Justina Calamia, Christopher Arian, Shireman, Balint Molnar, Miklos Horvath, Josh Kellogg, Matthew Layton, John White, Nadja Cech, Richard Boyce, Jashvant Unadkat, Kenneth Thummel, Mary Paine, 2020, Clinical Pharmacology & Therapeutics on p. 1342-1352

The Chemistry of Kratom [ Mitragyna speciosa]: Updated Characterization Data and Methods to Elucidate Indole and Oxindole Alkaloids

Laura Flores-Bocanegra, Huzefa A. Raja, Tyler N. Graf, Mario Augustinović, E. Diane Wallace, Shabnam Hematian, Joshua J. Kellogg, Daniel A. Todd, Nadja B. Cech, Nicholas H. Oberlies, 2020, Journal of Natural Products on p. 2165-2177

Identification of adulteration in botanical samples with untargeted metabolomics

E. Diane Wallace, Daniel A. Todd, James M. Harnly, Nadja B. Cech, Joshua J. Kellogg, 2020, Fresenius Zeitschrift fur Analytische Chemie on p. 4273-4286

Chemical evaluation of the effects of storage conditions on the botanical goldenseal using marker-based and metabolomics approaches

Manead Khin, Nadja B. Cech, Joshua J. Kellogg, Lindsay K. Caesar, 2020, Yale Journal of Biology and Medicine on p. 265-275

Most-Cited Papers

Biochemometrics for Natural Products Research: Comparison of Data Analysis Approaches and Application to Identification of Bioactive Compounds

Joshua J. Kellogg, Daniel A. Todd, Joseph M. Egan, Huzefa A. Raja, Nicholas H. Oberlies, Olav M. Kvalheim, Nadja B. Cech, 2016, Journal of Natural Products on p. 376-386

Endolichenic fungi: a new source of rich bioactive secondary metabolites on the horizon

Joshua J. Kellogg, Huzefa A. Raja, 2017, Phytochemistry Reviews on p. 271-293

Phlorotannins from alaskan seaweed inhibit carbolytic enzyme activity

Joshua Kellogg, Mary H. Grace, Mary Ann Lila, 2014, Marine Drugs on p. 5277-5294

Selection and characterization of botanical natural products for research studies: A NaPDI center recommended approach

Joshua J. Kellogg, Mary F. Paine, Jeannine S. McCune, Nicholas H. Oberlies, Nadja B. Cech, 2019, Natural Product Reports on p. 1196-1221

Biochemometrics to Identify Synergists and Additives from Botanical Medicines: A Case Study with Hydrastis canadensis (Goldenseal)

Emily R. Britton, Joshua J. Kellogg, Olav M. Kvalheim, Nadja B. Cech, 2018, Journal of Natural Products on p. 484-493

Quantification for non-targeted LC/MS screening without standard substances

Jaanus Liigand, Tingting Wang, Joshua Kellogg, Jørn Smedsgaard, Nadja Cech, Anneli Kruve, 2020, Scientific Reports

Comparison of Metabolomics Approaches for Evaluating the Variability of Complex Botanical Preparations: Green Tea (Camellia sinensis) as a Case Study

Joshua J. Kellogg, Tyler N. Graf, Mary F. Paine, Jeannine S. McCune, Olav M. Kvalheim, Nicholas H. Oberlies, Nadja B. Cech, 2017, Journal of Natural Products on p. 1457-1466

Opportunities and Limitations for Untargeted Mass Spectrometry Metabolomics to Identify Biologically Active Constituents in Complex Natural Product Mixtures

Lindsay K. Caesar, Joshua J. Kellogg, Olav M. Kvalheim, Nadja B. Cech, 2019, Journal of Natural Products on p. 469-484