Joshua Kellogg

Emphasis Area Representative, Molecular Toxicology; Assistant Professor of Veterinary and Biomedical Sciences

Joshua Kellogg

Research Summary

Development of new metabolomics tools for chemical and biological characterization of complex systems. Discovery of new natural products from plants and microorganisms with novel bioactivity against pathogenic fungi and neglected tropical diseases. Bioanalytical techniques to probe the mechanism of action and basic biology of these target organisms. Ethnobotany and indigenous knowledge surrounding plant-based medicine.

Huck Graduate Students

Huck Affiliations

Links

Most Recent Publications

Application of predictive modeling tools for the identification of Ocimum spp. herbal products

Evelyn Abraham, Sarah Chamberlain, Willam Perera, R Jordan, Joshua Kellogg, 2025, Fresenius Zeitschrift fur Analytische Chemie on p. 1479-1495

Nutrient limitation determines biological interactions between a mixotrophic Chrysophyte and toxin-producing Microcystis

Sarah Princiotta, Devinda Hiripitiyage, Yasawantha Hiripitiyage, D Holen, Joshua Kellogg, Belinda Sturm, Belinda Strum, Tedd Harris, 2025, Journal of Plankton Research on p. fbae7

An O-methylflavone from Artemisia afra kills non-replicating hypoxic Mycobacterium tuberculosis

Joshua J. Kellogg, Maria Natalia Alonso, R. Teal Jordan, Junpei Xiao, Juan Hilario Cafiero, Trevor Bush, Xiaoling Chen, Melissa Towler, Pamela Weathers, Scarlet S. Shell, 2024, Journal of Ethnopharmacology

High Cannabigerol Hemp Extract Moderates Colitis and Modulates the Microbiome in an Inflammatory Bowel Disease Model

Benjamin Anderson, Diana Sepulveda, Rahul Nachnani, Alonso Cortez-Resendiz, Matthew Coates, Aviauna Beckett, J Bisanz, A Beckett, W Raup-Konsavage, Jordan Bisanz, Joshua Kellogg, Wesley Raup-Konsavage, 2024, Journal of Pharmacology and Experimental Therapeutics on p. 331-341

Effect of Hemp Extraction Procedures on Cannabinoid and Terpenoid Composition

Francisco T. Chacon, Wesley Raup-Konsavage, Kent Vrana, Joshua Kellogg, 2024, Plants

The Potential of Cannabichromene (CBC) as a Therapeutic Agent

Diana Sepulveda, Kent Vrana, Joshua Kellogg, Jordan Bisanz, Dhimant Desai, Nicholas M. Graziane, Wesley Raup-Konsavage, 2024, Journal of Pharmacology and Experimental Therapeutics on p. 206-213

Advancing botanical safety: A strategy for selecting, sourcing, and characterizing botanicals for developing toxicological tools

Suramya Waidyanatha, Bradley J. Collins, Tim Cristy, Michelle Embry, Stefan Gafner, Holly Johnson, Josh Kellogg, Julie Krzykwa, Siheng Li, Constance A. Mitchell, Esra Mutlu, Sarah Pickett, Hong You, Richard Van Breemen, Timothy R. Baker, 2024, Food and Chemical Toxicology

Goldenseal (Hydrastis canadensis L.) Extracts Inhibit the Growth of Fungal Isolates Associated with American Ginseng (Panax quinquefolius L.)

Ying Gao, Ethan Swiggart, Kaela Wolkiewicz, Prabha Liyanapathiranage, Fulya Baysal-Gurel, Farhat Avin, Eleanor Lopez, Rebecca Jordan, Joshua Kellogg, Eric Burkhart, 2024, Molecules on p. 556

Three Ecological Models to Evaluate the Effectiveness of Trichoderma spp. for Suppressing Aflatoxigenic Aspergillus flavus and Aspergillus parasiticus

Nataliia Voloshchuk, Zilfa Irakoze, S Kang, Joshua J. Kellogg, Josephine Wee, 2024, Toxins on p. 314

Plant-associated volatile organic compound (VOC) database (PVD): A resource supporting research on VOCs produced by plants and plant-associated microbes

Danying Shao, Carl Schlagnhaufer, Ananda Bandara, Paul Esker, Seong Kim, Joshua Kellogg, Jisoo Jang, S Kang, 2024, Phytofrontiers on p. 840--842

Most-Cited Papers

Biochemometrics for Natural Products Research: Comparison of Data Analysis Approaches and Application to Identification of Bioactive Compounds

Joshua J. Kellogg, Daniel A. Todd, Joseph M. Egan, Huzefa A. Raja, Nicholas H. Oberlies, Olav M. Kvalheim, Nadja B. Cech, 2016, Journal of Natural Products on p. 376-386

Endolichenic fungi: a new source of rich bioactive secondary metabolites on the horizon

Joshua J. Kellogg, Huzefa A. Raja, 2017, Phytochemistry Reviews on p. 271-293

Quantification for non-targeted LC/MS screening without standard substances

Jaanus Liigand, Tingting Wang, Joshua Kellogg, Jørn Smedsgaard, Nadja Cech, Anneli Kruve, 2020, Scientific Reports

The Chemistry of Kratom [ Mitragyna speciosa]: Updated Characterization Data and Methods to Elucidate Indole and Oxindole Alkaloids

Laura Flores-Bocanegra, Huzefa A. Raja, Tyler N. Graf, Mario Augustinović, E. Diane Wallace, Shabnam Hematian, Joshua J. Kellogg, Daniel A. Todd, Nadja B. Cech, Nicholas H. Oberlies, 2020, Journal of Natural Products on p. 2165-2177

Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions

D. A. Todd, J. J. Kellogg, E. D. Wallace, M. Khin, L. Flores-Bocanegra, R. S. Tanna, S. McIntosh, H. A. Raja, T. N. Graf, S. E. Hemby, M. F. Paine, N. H. Oberlies, N. B. Cech, 2020, Scientific Reports

Selection and characterization of botanical natural products for research studies: A NaPDI center recommended approach

Joshua J. Kellogg, Mary F. Paine, Jeannine S. McCune, Nicholas H. Oberlies, Nadja B. Cech, 2019, Natural Product Reports on p. 1196-1221

Opportunities and Limitations for Untargeted Mass Spectrometry Metabolomics to Identify Biologically Active Constituents in Complex Natural Product Mixtures

Lindsay K. Caesar, Joshua J. Kellogg, Olav M. Kvalheim, Nadja B. Cech, 2019, Journal of Natural Products on p. 469-484

Biochemometrics to Identify Synergists and Additives from Botanical Medicines: A Case Study with Hydrastis canadensis (Goldenseal)

Emily R. Britton, Joshua J. Kellogg, Olav M. Kvalheim, Nadja B. Cech, 2018, Journal of Natural Products on p. 484-493

Comparison of Metabolomics Approaches for Evaluating the Variability of Complex Botanical Preparations: Green Tea (Camellia sinensis) as a Case Study

Joshua J. Kellogg, Tyler N. Graf, Mary F. Paine, Jeannine S. McCune, Olav M. Kvalheim, Nicholas H. Oberlies, Nadja B. Cech, 2017, Journal of Natural Products on p. 1457-1466

Integration of Biochemometrics and Molecular Networking to Identify Antimicrobials in Angelica keiskei

Lindsay K. Caesar, Joshua J. Kellogg, Olav M. Kvalheim, Richard A. Cech, Nadja B. Cech, 2018, Planta Medica on p. 721-728

News Articles Featuring Joshua Kellogg

Feb 10, 2025

Sustainable Labs Program increases participant engagement, welcomes new labs

Two upcoming virtual sessions will cover how labs can learn more and join next year’s cohort.

Full Article

Oct 13, 2024

Plant compound may help fight TB

A compound found in African wormwood — a plant used medicinally for thousands of years to treat many types of illness — could be effective against tuberculosis, according to a new study that is available online and will be published in the October edition of the Journal of Ethnopharmacology.

Full Article

Oct 01, 2024

Plant compound used in traditional medicine may help fight tuberculosis

A compound found in African wormwood — a plant used medicinally for thousands of years to treat many types of illness — could be effective against tuberculosis.

Full Article

Oct 16, 2023

Grants awarded to Penn State faculty for tropical ecosystems research in Belize

Three projects have been awarded seed grants as part of the Penn State-Belize Foundation for Research and Environmental Education Research and Education Initiative to develop agroforestry systems .

Full Article

Sep 15, 2023

Seed grants fund research collaborations with minority-serving institutions

The first awardees of Penn State’s new Inter-Institutional Partnerships for Diversifying Research (IDPR) initiative have been selected, comprising a total of 16 collaborative projects that connect Penn State researchers with colleagues from minority-serving institutions (MSIs).

Full Article

Aug 09, 2023

College of Ag Sciences scientist receives grant to study gut homeostasis, diet

Can plants evolved to resist infection help humans do the same?

Full Article

Apr 18, 2025

Remarkable African plant could revolutionize tuberculosis treatment

Discover how African wormwood could revolutionize tuberculosis treatment by targeting active and dormant bacteria with promising natural compounds..

Full Article