Joshua Kellogg

Emphasis Area Representative, Molecular Toxicology; Assistant Professor of Veterinary and Biomedical Sciences

Joshua Kellogg

Research Summary

Development of new metabolomics tools for chemical and biological characterization of complex systems. Discovery of new natural products from plants and microorganisms with novel bioactivity against pathogenic fungi and neglected tropical diseases. Bioanalytical techniques to probe the mechanism of action and basic biology of these target organisms. Ethnobotany and indigenous knowledge surrounding plant-based medicine.

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Biological Products Metabolomics Mass Spectrometry Occurrence In Nature In Vitro Techniques Liquid Chromatography Fungi Fractionation Mixture Hydrastis Complex Mixtures Metabolites Indole Alkaloids Oxindoles Oxides Tea Drug Interactions Mitragyna Antimicrobial Agent Mitragynine Biological Assay Dietary Supplements Industry Alkaloids Research Personnel

Most Recent Publications

Chemical Analyses for Botanicals to Develop a Toxicological Tool-Kit

Suramya Waidyanatha, Bradley Collins, Tim Cristy, Michelle Embry, Stefan Gafner, Holly Johnson, Joshua Kellogg, Julie Krzykwa, Siheng Li, Constance Mitchell, Esra Mutulu, Sarah Pickett, Hong You, Richard vanBreemen, Tim Baker, 2024, Food and Chemical Toxicology on p. 114537

Goldenseal (Hydrastis canadensis L.) Extracts Inhibit the Growth of Fungal Isolates Associated with American Ginseng (Panax quinquefolius L.)

Ying Gao, Ethan Swiggart, Kaela Wolkiewicz, Prabha Liyanapathiranage, Fulya Baysal-Gurel, Farhat A. Avin, Eleanor F.P. Lopez, Rebecca T. Jordan, Joshua Kellogg, Eric P. Burkhart, 2024, Molecules

A methoxylated flavone from Artemisia afra kills Mycobacterium tuberculosis

Josh Kellogg, Maria Alonso, R Jordan, Junpei Xiao, Juan Cafiero, Trevor Bush, Melissa Towler, Pamela Weathers, Scarlet Shell, 2023, BioRXiv on p. 10.11.561885

A comparison of high- and low-resolution gas chromatography–mass spectrometry for herbal product classification: A case study with Ocimum essential oils

Evelyn J. Abraham, E. Diane Wallace, Joshua J. Kellogg, 2023, Phytochemical Analysis on p. 680-691

Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)

Xiaoling Chen, Andrew D. Patterson, Gary H. Perdew, Iain A. Murray, Joshua J. Kellogg, 2023, Journal of Functional Foods

Interaction Metabolomics to Discover Synergists in Natural Product Mixtures

Warren S. Vidar, Tim U.H. Baumeister, Lindsay K. Caesar, Joshua J. Kellogg, Daniel A. Todd, Roger G. Linington, Olav M. Kvalheim, Nadja B. Cech, 2023, Journal of Natural Products on p. 655-671

Secondary Terpenes in Cannabis sativa L.: Synthesis and Synergy

Francisco Chacon, Wesley M. Raup-Konsavage, Kent E. Vrana, Joshua Kellogg, 2022, Biomedicines on p. 3124

Untargeted metabolomics for the study of antiinfective plants

Joshua J. Kellogg, 2022, on p. 335-359

Chemometric-Guided Approaches for Profiling and Authenticating Botanical Materials

Evelyn J. Abraham, Joshua J. Kellogg, 2021, Frontiers in Nutrition

Assessing Transporter-Mediated Natural Product-Drug Interactions Via In vitro-In Vivo Extrapolation: Clinical Evaluation With a Probe Cocktail

James T. Nguyen, Dan Dan Tian, Rakshit S. Tanna, Deena L. Hadi, Sumit Bansal, Justina C. Calamia, Christopher M. Arian, Laura M. Shireman, Bálint Molnár, Miklós Horváth, Joshua J. Kellogg, Matthew E. Layton, John R. White, Nadja B. Cech, Richard D. Boyce, Jashvant D. Unadkat, Kenneth E. Thummel, Mary F. Paine, 2021, Clinical Pharmacology and Therapeutics on p. 1342-1352

Most-Cited Papers

Biochemometrics for Natural Products Research: Comparison of Data Analysis Approaches and Application to Identification of Bioactive Compounds

Joshua J. Kellogg, Daniel A. Todd, Joseph M. Egan, Huzefa A. Raja, Nicholas H. Oberlies, Olav M. Kvalheim, Nadja B. Cech, 2016, Journal of Natural Products on p. 376-386

Endolichenic fungi: a new source of rich bioactive secondary metabolites on the horizon

Joshua J. Kellogg, Huzefa A. Raja, 2017, Phytochemistry Reviews on p. 271-293

Quantification for non-targeted LC/MS screening without standard substances

Jaanus Liigand, Tingting Wang, Joshua Kellogg, Jørn Smedsgaard, Nadja Cech, Anneli Kruve, 2020, Scientific Reports

Phlorotannins from alaskan seaweed inhibit carbolytic enzyme activity

Joshua Kellogg, Mary H. Grace, Mary Ann Lila, 2014, Marine Drugs on p. 5277-5294

Selection and characterization of botanical natural products for research studies: A NaPDI center recommended approach

Joshua J. Kellogg, Mary F. Paine, Jeannine S. McCune, Nicholas H. Oberlies, Nadja B. Cech, 2019, Natural Product Reports on p. 1196-1221

The Chemistry of Kratom [ Mitragyna speciosa]: Updated Characterization Data and Methods to Elucidate Indole and Oxindole Alkaloids

Laura Flores-Bocanegra, Huzefa A. Raja, Tyler N. Graf, Mario Augustinović, E. Diane Wallace, Shabnam Hematian, Joshua J. Kellogg, Daniel A. Todd, Nadja B. Cech, Nicholas H. Oberlies, 2020, Journal of Natural Products on p. 2165-2177

Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions

D. A. Todd, J. J. Kellogg, E. D. Wallace, M. Khin, L. Flores-Bocanegra, R. S. Tanna, S. McIntosh, H. A. Raja, T. N. Graf, S. E. Hemby, M. F. Paine, N. H. Oberlies, N. B. Cech, 2020, Scientific Reports

Biochemometrics to Identify Synergists and Additives from Botanical Medicines: A Case Study with Hydrastis canadensis (Goldenseal)

Emily R. Britton, Joshua J. Kellogg, Olav M. Kvalheim, Nadja B. Cech, 2018, Journal of Natural Products on p. 484-493

Opportunities and Limitations for Untargeted Mass Spectrometry Metabolomics to Identify Biologically Active Constituents in Complex Natural Product Mixtures

Lindsay K. Caesar, Joshua J. Kellogg, Olav M. Kvalheim, Nadja B. Cech, 2019, Journal of Natural Products on p. 469-484

Comparison of Metabolomics Approaches for Evaluating the Variability of Complex Botanical Preparations: Green Tea (Camellia sinensis) as a Case Study

Joshua J. Kellogg, Tyler N. Graf, Mary F. Paine, Jeannine S. McCune, Olav M. Kvalheim, Nicholas H. Oberlies, Nadja B. Cech, 2017, Journal of Natural Products on p. 1457-1466