Jeffrey Peters
Distinguished Professor of Molecular Toxicology and Carcinogenesis

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312 Huck Life Sciences
University Park, PA 16802 - jmp21@psu.edu
- 814-863-1387
Research Summary
Roles of peroxisome proliferator-activated receptors (PPARs) in the regulation of homeostasis, toxicology, and carcinogenesis.
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Peroxisome Proliferator Activated Receptors Neoplasms Tumors Pharmacological Metabolism Liver Cytoplasmic And Nuclear Receptors Ligand Peroxisome Proliferator Activated Receptor Agonist Fatty Acid Rodentia Perfluorooctane Sulfonic Acid Aryl Hydrocarbon Receptors Dose Ppar Alpha Fatty Acid Synthases Industrial Substance Macrophage Colony Stimulating Factor Cannabidiolic Acid Weight Drug Ligands Carcinogenesis Genes Oxidative Stress CellsMost Recent Publications
Xenobiotic Receptor-Mediated Toxicity
GH Perdew, IA Murray, JM Peters,
Cannabidiolic acid activates the expression of the PPARβ/δ target genes in MDA-MB-231 cells
Masayo Hirao-Suzuki, Koga Takayuki, Masufumi Takiguchi, Jeffrey M. Peters, Shuso Takeda, 2022, Archives of Biochemistry and Biophysics
2020-2021 Toxicological Sciences Paper of the Year
J. Christopher States, Jeffrey M. Peters, 2022, Toxicological Sciences on p. 177-178
Targeting peroxisome proliferator-activated receptor-β/δ (pparβ/δ) for the treatment or prevention of alcoholic liver disease
Takayuki Koga, Jeffrey M. Peters, 2021, Biological and Pharmaceutical Bulletin on p. 1598-1606
Species Differences between Mouse and Human PPARα in Modulating the Hepatocarcinogenic Effects of Perinatal Exposure to a High-Affinity Human PPARα Agonist in Mice
Jennifer E. Foreman, Takayuki Koga, Oksana Kosyk, Boo Hyon Kang, Xiaoyang Zhu, Samuel M. Cohen, Laura J. Billy, Arun K. Sharma, Shantu Amin, Frank J. Gonzalez, Ivan Rusyn, Jeffrey M. Peters, 2021, Toxicological Sciences on p. 81-92
Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in PPARA-Humanized Mice
Jennifer E. Foreman, Takayuki Koga, Oksana Kosyk, Boo Hyon Kang, Xiaoyang Zhu, Samuel M. Cohen, Laura J. Billy, Arun K. Sharma, Shantu Amin, Frank J. Gonzalez, Ivan Rusyn, Jeffrey M. Peters, 2021, Toxicological Sciences on p. 70-80
Current Challenges and Recent Developments in Mass Spectrometry-Based Metabolomics
Stephanie L. Collins, Imhoi Koo, Jeffrey M. Peters, Philip B. Smith, Andrew D. Patterson, 2021, Annual Review of Analytical Chemistry on p. 467-487
Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice
Limin Zhang, Bipin Rimal, Robert G. Nichols, Yuan Tian, Philip B. Smith, Emmanuel Hatzakis, Shu Ching Chang, John L. Butenhoff, Jeffrey M. Peters, Andrew D. Patterson, 2020, Toxicology
Moving forward with ToxSci
Jeffrey M. Peters, 2020, Toxicological Sciences on p. 227-228
Change is Good: What is New for ToxSci?
Jeffrey M. Peters, 2020, Toxicological Sciences on p. 1-2
Most-Cited Papers
Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study
J. Christopher Corton, Michael L. Cunningham, B. Timothy Hummer, Christopher Lau, Bette Meek, Jeffrey M. Peters, James A. Popp, Lorenz Rhomberg, Jennifer Seed, James E. Klaunig, 2014, Critical Reviews in Toxicology on p. 1-49
Lipid metabolism and lipophagy in cancer
Meenu Maan, Jeffrey M. Peters, Mainak Dutta, Andrew D. Patterson, 2018, Biochemical and Biophysical Research Communications on p. 582-589
The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions
J. Christopher Corton, Jeffrey M. Peters, James E. Klaunig, 2018, Archiv fur Toxikologie on p. 83-119
Establishing the Role of PPARβ/δ in Carcinogenesis
Jeffrey M. Peters, Frank J. Gonzalez, Rolf Müller, 2015, Trends in Endocrinology and Metabolism on p. 595-607
M-CSF from cancer cells induces fatty acid synthase and PPARβ/δ activation in tumor myeloid cells, leading to tumor progression
Jonghanne Park, Sang Eun Lee, Jin Hur, Eun Byeol Hong, Jae Il Choi, Ji Min Yang, Ju Young Kim, Young Chan Kim, Hyun Jai Cho, Jeffrey M. Peters, Seung Bum Ryoo, Young Tae Kim, Hyo Soo Kim, 2015, Cell Reports on p. 1614-1625
Activation of peroxisome proliferator-activated receptor-β/δ (PPAR-β/δ) inhibits human breast cancer cell line tumorigenicity
Pei Li Yao, Jose L. Morales, Bokai Zhu, Boo Hyon Kang, Frank J. Gonzalez, Jeffrey M. Peters, 2014, Molecular Cancer Therapeutics on p. 1008-1017
Interplay Between the Host, the Human Microbiome, and Drug Metabolism
Robert G. Nichols, Jeffrey M. Peters, Andrew D. Patterson, 2019, Human Genomics
The nuclear receptor peroxisome proliferator-activated receptor-β/ δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress
Bokai Zhu, Christina H. Ferry, Lauren K. Markell, Nicholas Blazanin, Adam B. Glick, Frank J. Gonzalez, Jeffrey M. Peters, 2014, Journal of Biological Chemistry on p. 20102-20119
Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritis
Tejas S. Lahoti, Jarod M. Hughes, Ann Kusnadi, Kaarthik John, Bokai Zhu, Iain A. Murray, Krishne Gowda, Jeffrey M. Peters, Shantu G. Amin, Gary H. Perdew, 2014, Journal of Pharmacology and Experimental Therapeutics on p. 236-245
PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling
B. Zhu, C. H. Ferry, N. Blazanin, M. T. Bility, C. Khozoie, B. H. Kang, A. B. Glick, F. J. Gonzalez, J. M. Peters, 2014, Oncogene on p. 5348-5359
News Articles Featuring Jeffrey Peters
Sep 02, 2022
Metabolomics Core Facility continues to expand while pushing scientific bounds
Established nearly a decade ago, Penn State’s Metabolomics Core Facility is housed in the Huck Institutes of the Life Sciences on the University Park campus.
Full Article
Jan 21, 2020
Persistent environmental contaminant changes the gut microbiome of mice
An industrial chemical — phased out since 2002, but previously used in stain and water-repellent products and firefighting foam — alters the gut microbiome of mice and could have implications for human health, according to an international team of researchers.
Full Article