Jeffrey Peters
Distinguished Professor of Molecular Toxicology and Carcinogenesis
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312 Huck Life Sciences
University Park, PA 16802 - jmp21@psu.edu
- 814-863-1387
Research Summary
Roles of peroxisome proliferator-activated receptors (PPARs) in the regulation of homeostasis, toxicology, and carcinogenesis.
Huck Graduate Students
Huck Affiliations
Links
Most Recent Publications
Xenobiotic Receptor-Mediated Toxicity
GH Perdew, IA Murray, JM Peters,
Differential hepatic activation of mouse and human peroxisome proliferator-activated receptor-α by perfluorohexane sulfonate
Yahya Khan, Annalee M. Schmidt, Kyle J. Oldro, Xiaoyang Zhu, Angelina R. Kramer, Sarah R. Hamilton, Katherine O. Bleil, Ryan M. Krisko, Jeremiah D. Zitzow, Yuan Tian, Shu Ching Chang, Vonn Walter, Samuel M. Cohen, Frank J. Gonzalez, Andrew D. Patterson, Jeffrey M. Peters, 2025, Toxicological Sciences on p. 47-52
2023–2024 Toxicological Sciences Paper of the Year
Deborah Cory-Slechta, Jeffrey M. Peters, 2025, Toxicological Sciences on p. 1
Thank You, ToxSci 2024 Reviewers
Jeffrey M. Peters, 2024, Toxicological Sciences on p. 153-156
Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation
Shigetoshi Yokoyama, Imhoi Koo, Daisuke Aibara, Yuan Tian, Iain Alexander Murray, Stephanie L. Collins, Denise M. Coslo, Mari Kono, Jeffrey Maurice Peters, Richard L. Proia, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2024, Advanced Science on p. e2400794
Chlorpyrifos modulates the mouse gut microbiota and metabolic activity
Robert G. Nichols, Bipin Rimal, Fuhua Hao, Jeffrey Maurice Peters, Emily R. Davenport, Andrew D. Patterson, 2024, Environmental International on p. 109022
Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids
Bokai Zhu, Xiaoyang Zhu, Michael G. Borland, Douglas H. Ralph, Christopher R. Chiaro, Kristopher W. Krausz, James M. Ntambi, Adam B. Glick, Andrew D. Patterson, Gary H. Perdew, Frank J. Gonzalez, Jeffrey M. Peters, 2024, Biomolecules
2022-2023 Toxicological Sciences: Paper of the Year
Yvonne Will, Jeffrey M. Peters, 2024, Toxicological Sciences on p. 2-3
Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in Ppara Transgenic Mice
Xiaoyang Zhu, Qing Liu, Andrew D. Patterson, Arun K. Sharma, Shantu G. Amin, Samuel M. Cohen, Frank J. Gonzalez, Jeffrey M. Peters, 2023, Metabolites
2021-2022 Toxicological Sciences paper of the year
Lei Guo, Jeffrey Peters, 2023, Toxicological Sciences on p. 1--2
Most-Cited Papers
Lipid metabolism and lipophagy in cancer
Meenu Maan, Jeffrey Peters, Mainak Dutta, Andrew D. Patterson, 2018, Biochemical and Biophysical Research Communications on p. 582--589
The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions
J. Christopher Corton, Jeffrey M. Peters, James E. Klaunig, 2018, Archiv fur Toxikologie on p. 83-119
M-CSF from cancer cells induces fatty acid synthase and PPARβ/δ activation in tumor myeloid cells, leading to tumor progression
Jonghanne Park, Sang Eun Lee, Jin Hur, Eun Byeol Hong, Jae Il Choi, Ji Min Yang, Ju Young Kim, Young Chan Kim, Hyun Jai Cho, Jeffrey M. Peters, Seung Bum Ryoo, Young Tae Kim, Hyo Soo Kim, 2015, Cell Reports on p. 1614-1625
Establishing the Role of PPARβ/δ in Carcinogenesis
Jeffrey M. Peters, Frank J. Gonzalez, Rolf Müller, 2015, Trends in Endocrinology and Metabolism on p. 595-607
Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice
Limin Zhang, Bipin Rimal, Robert Nichols, Yuan Tian, Philip B. Smith, Emmanuel Hatzakis, Shu-Ching Chang, John Butenhoff, Jeffrey Peters, Andrew D. Patterson, 2020, Toxicology on p. 152365
Interplay Between the Host, the Human Microbiome, and Drug Metabolism
Robert Nichols, Jeffrey Peters, Andrew D. Patterson, 2019, Human Genomics on p. 1--10
Current Challenges and Recent Developments in Mass Spectrometry-Based Metabolomics
Stephanie Collins, Imhoi Koo, Jeffrey Peters, Philip B. Smith, Andrew D. Patterson, 2021, Annual Review of Analytical Chemistry on p. 467--487
The Evolution of Carcinogenesis
Jeffrey M. Peters, Frank J. Gonzalez, 2018, Toxicological Sciences on p. 272-276
PPARβ/δ selectively regulates phenotypic features of age-related macular degeneration
Mayur Choudhary, Jin dong Ding, Xiaoping Qi, Michael E. Boulton, Pei Li Yao, Jeffrey M. Peters, Goldis Malek, 2016, Aging on p. 1952-1978
Molecular Regulation of Carcinogenesis: Friend and Foe
Andrew D. Patterson, Frank Gonzalez, Gary Perdew, Jeffrey Peters, 2018, Toxicological Sciences on p. 277--283
News Articles Featuring Jeffrey Peters
Jun 24, 2025
Ten interdisciplinary research teams awarded IEE seed grants
Ten interdisciplinary research teams have received funding through the Institute of Energy and the Environment’s (IEE) 2025 Seed Grant Program.
Full Article
Sep 02, 2022
Metabolomics Core Facility continues to expand while pushing scientific bounds
Established nearly a decade ago, Penn State’s Metabolomics Core Facility is housed in the Huck Institutes of the Life Sciences on the University Park campus.
Full Article
Jan 21, 2020
Persistent environmental contaminant changes the gut microbiome of mice
An industrial chemical — phased out since 2002, but previously used in stain and water-repellent products and firefighting foam — alters the gut microbiome of mice and could have implications for human health, according to an international team of researchers.
Full Article