Jeffrey Peters

Distinguished Professor of Molecular Toxicology and Carcinogenesis

Jeffrey Peters

Research Summary

Roles of peroxisome proliferator-activated receptors (PPARs) in the regulation of homeostasis, toxicology, and carcinogenesis.

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Peroxisome Proliferator Activated Receptors Neoplasms Tumors Pharmacological Metabolism Liver Cytoplasmic And Nuclear Receptors Ligand Peroxisome Proliferator Activated Receptor Agonist Fatty Acid Rodentia Perfluorooctane Sulfonic Acid Aryl Hydrocarbon Receptors Dose Ppar Alpha Fatty Acid Synthases Industrial Substance Macrophage Colony Stimulating Factor Cannabidiolic Acid Weight Drug Ligands Carcinogenesis Genes Oxidative Stress Cells

Most Recent Publications

Xenobiotic Receptor-Mediated Toxicity

GH Perdew, IA Murray, JM Peters,

Cannabidiolic acid activates the expression of the PPARβ/δ target genes in MDA-MB-231 cells

Masayo Hirao-Suzuki, Koga Takayuki, Masufumi Takiguchi, Jeffrey M. Peters, Shuso Takeda, 2022, Archives of Biochemistry and Biophysics

2020-2021 Toxicological Sciences Paper of the Year

J. Christopher States, Jeffrey M. Peters, 2022, Toxicological Sciences on p. 177-178

Targeting peroxisome proliferator-activated receptor-β/δ (pparβ/δ) for the treatment or prevention of alcoholic liver disease

Takayuki Koga, Jeffrey M. Peters, 2021, Biological and Pharmaceutical Bulletin on p. 1598-1606

Species Differences between Mouse and Human PPARα in Modulating the Hepatocarcinogenic Effects of Perinatal Exposure to a High-Affinity Human PPARα Agonist in Mice

Jennifer E. Foreman, Takayuki Koga, Oksana Kosyk, Boo Hyon Kang, Xiaoyang Zhu, Samuel M. Cohen, Laura J. Billy, Arun K. Sharma, Shantu Amin, Frank J. Gonzalez, Ivan Rusyn, Jeffrey M. Peters, 2021, Toxicological Sciences on p. 81-92

Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in PPARA-Humanized Mice

Jennifer E. Foreman, Takayuki Koga, Oksana Kosyk, Boo Hyon Kang, Xiaoyang Zhu, Samuel M. Cohen, Laura J. Billy, Arun K. Sharma, Shantu Amin, Frank J. Gonzalez, Ivan Rusyn, Jeffrey M. Peters, 2021, Toxicological Sciences on p. 70-80

Current Challenges and Recent Developments in Mass Spectrometry-Based Metabolomics

Stephanie L. Collins, Imhoi Koo, Jeffrey M. Peters, Philip B. Smith, Andrew D. Patterson, 2021, Annual Review of Analytical Chemistry on p. 467-487

Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice

Limin Zhang, Bipin Rimal, Robert G. Nichols, Yuan Tian, Philip B. Smith, Emmanuel Hatzakis, Shu Ching Chang, John L. Butenhoff, Jeffrey M. Peters, Andrew D. Patterson, 2020, Toxicology

Moving forward with ToxSci

Jeffrey M. Peters, 2020, Toxicological Sciences on p. 227-228

Change is Good: What is New for ToxSci?

Jeffrey M. Peters, 2020, Toxicological Sciences on p. 1-2

Most-Cited Papers

Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study

J. Christopher Corton, Michael L. Cunningham, B. Timothy Hummer, Christopher Lau, Bette Meek, Jeffrey M. Peters, James A. Popp, Lorenz Rhomberg, Jennifer Seed, James E. Klaunig, 2014, Critical Reviews in Toxicology on p. 1-49

Lipid metabolism and lipophagy in cancer

Meenu Maan, Jeffrey M. Peters, Mainak Dutta, Andrew D. Patterson, 2018, Biochemical and Biophysical Research Communications on p. 582-589

The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions

J. Christopher Corton, Jeffrey M. Peters, James E. Klaunig, 2018, Archiv fur Toxikologie on p. 83-119

Establishing the Role of PPARβ/δ in Carcinogenesis

Jeffrey M. Peters, Frank J. Gonzalez, Rolf Müller, 2015, Trends in Endocrinology and Metabolism on p. 595-607

M-CSF from cancer cells induces fatty acid synthase and PPARβ/δ activation in tumor myeloid cells, leading to tumor progression

Jonghanne Park, Sang Eun Lee, Jin Hur, Eun Byeol Hong, Jae Il Choi, Ji Min Yang, Ju Young Kim, Young Chan Kim, Hyun Jai Cho, Jeffrey M. Peters, Seung Bum Ryoo, Young Tae Kim, Hyo Soo Kim, 2015, Cell Reports on p. 1614-1625

Activation of peroxisome proliferator-activated receptor-β/δ (PPAR-β/δ) inhibits human breast cancer cell line tumorigenicity

Pei Li Yao, Jose L. Morales, Bokai Zhu, Boo Hyon Kang, Frank J. Gonzalez, Jeffrey M. Peters, 2014, Molecular Cancer Therapeutics on p. 1008-1017

Interplay Between the Host, the Human Microbiome, and Drug Metabolism

Robert G. Nichols, Jeffrey M. Peters, Andrew D. Patterson, 2019, Human Genomics

The nuclear receptor peroxisome proliferator-activated receptor-β/ δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress

Bokai Zhu, Christina H. Ferry, Lauren K. Markell, Nicholas Blazanin, Adam B. Glick, Frank J. Gonzalez, Jeffrey M. Peters, 2014, Journal of Biological Chemistry on p. 20102-20119

Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritis

Tejas S. Lahoti, Jarod M. Hughes, Ann Kusnadi, Kaarthik John, Bokai Zhu, Iain A. Murray, Krishne Gowda, Jeffrey M. Peters, Shantu G. Amin, Gary H. Perdew, 2014, Journal of Pharmacology and Experimental Therapeutics on p. 236-245

PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling

B. Zhu, C. H. Ferry, N. Blazanin, M. T. Bility, C. Khozoie, B. H. Kang, A. B. Glick, F. J. Gonzalez, J. M. Peters, 2014, Oncogene on p. 5348-5359