Professor and Huck Chair of Molecular Toxicology
The Patterson lab is focused on understanding the host-metabolite-microbiome axis
- Metabolomics Facility
- Integrative and Biomedical Physiology
- Molecular, Cellular, and Integrative Biosciences
- Bioinformatics and Genomics
- Center for Molecular Toxicology and Carcinogenesis
- Microbiome Center
Publication TagsObesity Metabolomics Parasites Metabolites Microbiota Intestines Gastrointestinal Microbiome Glycine Muricholic Acid Homeostasis Liver Tempol Bile Acids And Salts Fungi Xenobiotics Radiation Muscles Cross Sectional Studies Non Alcoholic Fatty Liver Disease Biomarkers Muscle Metabolism Acids Genistein Mice
Most Recent Papers
Metabolic Profiling Reveals Aggravated Non-Alcoholic Steatohepatitis in High-Fat High-Cholesterol Diet-Fed Apolipoprotein E-Deficient Mice Lacking Ron Receptor Signaling.
J Allen, A Dey, Jingjing Cai, J Zhang, Y Tian, Mary Kennett, Yanyuan Ma, T Liang, Andrew Patterson, Pamela Hankey, 2020, Metabolites
Lipocalin 2 deficiency-induced gut microbiota dysbiosis evokes metabolic syndrome in aged mice.
Vishal Singh, S Galla, R Golonka, Andrew Patterson, B Chassaing, B Joe, M Vijay-Kumar, 2020, Physiological genomics on p. 314-321
Impact of Facultative Bacteria on the Metabolic Function of an Obligate Insect-Bacterial Symbiosis.
F Blow, Ankrah NYD, N Clark, I Koo, E Allman, Q Liu, M Anitha, Andrew Patterson, A Douglas, 2020, mBio
The microbiome modulating activity of bile acids.
Y Tian, W Gui, I Koo, Philip Smith, E Allman, R Nichols, B Rimal, J Cai, Q Liu, Andrew Patterson, 2020, Gut microbes on p. 979-996
Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice.
L Zhang, B Rimal, R Nichols, Y Tian, Philip Smith, E Hatzakis, S Chang, J Butenhoff, Jeffrey Peters, Andrew Patterson, 2020, Toxicology on p. 152365
Metatranscriptomic Analysis of the Mouse Gut Microbiome Response to the Persistent Organic Pollutant 2,3,7,8-Tetrachlorodibenzofuran.
Renea Nichols, Jian Zhang, Jingjing Cai, Iain Murray, I Koo, Philip Smith, Gary Perdew, Andrew Patterson, 2019, Metabolites
The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2
Lei Bao, Fernanda Festa, Christopher S. Freet, John P. Lee, Iwona M. Hirschler-Laszkiewicz, Shu jen Chen, Kerry A. Keefer, Hong Gang Wang, Andrew D. Patterson, Joseph Y. Cheung, Barbara A. Miller, 2019, Scientific reports
Specialist and generalist fungal parasites induce distinct biochemical changes in the mandible muscles of their host
Shanshan Zheng, Raquel Loreto, Philip Smith, Andrew Patterson, David Hughes, Liande Wang, 2019, International journal of molecular sciences
Nutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass
D. Nyasha Chagwedera, Qi Yan Ang, Jordan E. Bisanz, Yew Ann Leong, Kirthana Ganeshan, Jingwei Cai, Andrew David Patterson, Peter J. Turnbaugh, Ajay Chawla, 2019, Cell Metabolism on p. 364-373.e7
Gender differences in phytoestrogens and the relationship with speed of processing in older adults: A cross-sectional analysis of NHANES, 1999–2002
Jessie Alwerdt, Andrew D. Patterson, Martin J. Sliwinski, 2019, Nutrients
Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
Fei Li, Changtao Jiang, Kristopher W. Krausz, Yunfei Li, Istvan Albert, Haiping Hao, Kristin M. Fabre, James B. Mitchell, Andrew D. Patterson, Frank J. Gonzalez, 2013, Nature communications
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu G. Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez, 2015, Nature communications
Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling
Andrew David Patterson, Olivier Maurhofer, Diren Beyoǧlu, Christian Lanz, Kristopher W. Krausz, Thomas Pabst, Frank J. Gonzalez, Jean François Dufour, Jeffrey R. Idle, 2011, Cancer Research on p. 6590-6600
Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis
Naoki Tanaka, Tsutomu Matsubara, Kristopher W. Krausz, Andrew D. Patterson, Frank J. Gonzalez, 2012, Hepatology on p. 118-129
Caroline H. Johnson, Andrew D. Patterson, Jeffrey R. Idle, Frank J. Gonzalez, 2012, Annual Review of Pharmacology and Toxicology on p. 37-56
Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation
Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental health perspectives on p. 679-688
Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles
Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific reports
Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity
Andrew D. Patterson, Yatrik M. Shah, Tsutomu Matsubara, Kristopher W. Krausz, Frank J. Gonzalez, 2012, Hepatology on p. 281-290
Radiation metabolomics. 4. UPLC-ESI-QTOFMS-based metabolomics for urinary biomarker discovery in gamma-irradiated rats
Caroline H. Johnson, Andrew D. Patterson, Kristopher W. Krausz, Christian Lanz, Dong Wook Kang, Hans Luecke, Frank J. Gonzalez, Jeffrey R. Idle, 2011, Radiation research on p. 473-484
News Articles Featuring Andrew Patterson
Mar 11, 2020
Listening to your gut: A powerful new tool on the microbiome and cell metabolism
Many aspects of our lives — not only the presence or absence of certain diseases, but conditions like obesity, sleep patterns, even mood — may be determined, to a surprising extent, by the microbes living inside of us.
Jan 21, 2020
Persistent environmental contaminant changes the gut microbiome of mice
An industrial chemical — phased out since 2002, but previously used in stain and water-repellent products and firefighting foam — alters the gut microbiome of mice and could have implications for human health, according to an international team of researchers.