Andrew Patterson

Professor and Huck Chair of Molecular Toxicology

Andrew Patterson

Research Summary

The Patterson lab is focused on understanding the host-metabolite-microbiome axis

Huck Affiliations


Publication Tags

Obesity Metabolomics Parasites Metabolites Microbiota Intestines Gastrointestinal Microbiome Glycine Muricholic Acid Homeostasis Liver Tempol Bile Acids And Salts Fungi Xenobiotics Radiation Muscles Cross Sectional Studies Non Alcoholic Fatty Liver Disease Biomarkers Muscle Metabolism Acids Genistein Mice

Most Recent Papers

Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity.

F Dong, F Hao, Iain Murray, Philip Smith, I Koo, A Tindall, Penny Kris-Etherton, Krishnegowda Gowdahalli, Shantu Amin, Andrew Patterson, Gary Perdew, 2020, Gut microbes on p. 1-24

Metabolic Profiling Reveals Aggravated Non-Alcoholic Steatohepatitis in High-Fat High-Cholesterol Diet-Fed Apolipoprotein E-Deficient Mice Lacking Ron Receptor Signaling.

J Allen, A Dey, Jingjing Cai, J Zhang, Y Tian, Mary Kennett, Yanyuan Ma, T Liang, Andrew Patterson, Pamela Hankey, 2020, Metabolites

Impact of Facultative Bacteria on the Metabolic Function of an Obligate Insect-Bacterial Symbiosis.

F Blow, Ankrah NYD, N Clark, I Koo, E Allman, Q Liu, M Anitha, Andrew Patterson, A Douglas, 2020, mBio

The microbiome modulating activity of bile acids.

Y Tian, W Gui, I Koo, Philip Smith, E Allman, R Nichols, B Rimal, J Cai, Q Liu, Andrew Patterson, 2020, Gut microbes on p. 979-996

Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice.

L Zhang, B Rimal, R Nichols, Y Tian, Philip Smith, E Hatzakis, S Chang, J Butenhoff, Jeffrey Peters, Andrew Patterson, 2020, Toxicology on p. 152365

Metatranscriptomic Analysis of the Mouse Gut Microbiome Response to the Persistent Organic Pollutant 2,3,7,8-Tetrachlorodibenzofuran.

Renea Nichols, Jian Zhang, Jingjing Cai, Iain Murray, I Koo, Philip Smith, Gary Perdew, Andrew Patterson, 2019, Metabolites

The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2

Lei Bao, Fernanda Festa, Christopher S. Freet, John P. Lee, Iwona M. Hirschler-Laszkiewicz, Shu jen Chen, Kerry A. Keefer, Hong Gang Wang, Andrew D. Patterson, Joseph Y. Cheung, Barbara A. Miller, 2019, Scientific reports

Specialist and generalist fungal parasites induce distinct biochemical changes in the mandible muscles of their host

Shanshan Zheng, Raquel Loreto, Philip Smith, Andrew Patterson, David Hughes, Liande Wang, 2019, International journal of molecular sciences

Nutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass

D. Nyasha Chagwedera, Qi Yan Ang, Jordan E. Bisanz, Yew Ann Leong, Kirthana Ganeshan, Jingwei Cai, Andrew David Patterson, Peter J. Turnbaugh, Ajay Chawla, 2019, Cell Metabolism on p. 364-373.e7

Gender differences in phytoestrogens and the relationship with speed of processing in older adults: A cross-sectional analysis of NHANES, 1999–2002

Jessie Alwerdt, Andrew D. Patterson, Martin J. Sliwinski, 2019, Nutrients

Most-Cited Papers

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

Fei Li, Changtao Jiang, Kristopher W. Krausz, Yunfei Li, Istvan Albert, Haiping Hao, Kristin M. Fabre, James B. Mitchell, Andrew D. Patterson, Frank J. Gonzalez, 2013, Nature communications

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu G. Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez, 2015, Nature communications

Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling

Andrew David Patterson, Olivier Maurhofer, Diren Beyoǧlu, Christian Lanz, Kristopher W. Krausz, Thomas Pabst, Frank J. Gonzalez, Jean François Dufour, Jeffrey R. Idle, 2011, Cancer Research on p. 6590-6600

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis

Naoki Tanaka, Tsutomu Matsubara, Kristopher W. Krausz, Andrew D. Patterson, Frank J. Gonzalez, 2012, Hepatology on p. 118-129

Xenobiotic metabolomics

Caroline H. Johnson, Andrew D. Patterson, Jeffrey R. Idle, Frank J. Gonzalez, 2012, Annual Review of Pharmacology and Toxicology on p. 37-56

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental health perspectives on p. 679-688

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific reports

Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity

Andrew D. Patterson, Yatrik M. Shah, Tsutomu Matsubara, Kristopher W. Krausz, Frank J. Gonzalez, 2012, Hepatology on p. 281-290

Radiation metabolomics. 4. UPLC-ESI-QTOFMS-based metabolomics for urinary biomarker discovery in gamma-irradiated rats

Caroline H. Johnson, Andrew D. Patterson, Kristopher W. Krausz, Christian Lanz, Dong Wook Kang, Hans Luecke, Frank J. Gonzalez, Jeffrey R. Idle, 2011, Radiation research on p. 473-484