Andrew Patterson

Professor and Huck Chair of Molecular Toxicology; Faculty Oversight, Metabolomics Core Facility

Andrew Patterson

Research Summary

The Patterson lab is focused on understanding the host-metabolite-microbiome axis

Huck Graduate Students

Huck Affiliations


Publication Tags

These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.

Gastrointestinal Microbiome Obesity Intestines Bile Acids And Salts Homeostasis Metabolic Glycine Muricholic Acid Glucose Microbiota Liver Dietary Fiber Acids High Fat Diet Tempol Acid Ceramides Pharmacological Metabolism Fermentation Diet Non Alcoholic Fatty Liver Disease Bile Acid Acetates Aryl Hydrocarbon Receptors Fats

Most Recent Publications

Sougat Misra, Tai Jung Lee, Aswathy Sebastian, John McGuigan, Chang Liao, Imhoi Koo, Andrew D. Patterson, Randall M. Rossi, Molly A. Hall, Istvan Albert, K. Sandeep Prabhu, 2023, Redox Biology

A microbiome-dependent gut–brain pathway regulates motivation for exercise

Lenka Dohnalová, Patrick Lundgren, Jamie R.E. Carty, Nitsan Goldstein, Sebastian L. Wenski, Pakjira Nanudorn, Sirinthra Thiengmag, Kuei Pin Huang, Lev Litichevskiy, Hélène C. Descamps, Karthikeyani Chellappa, Ana Glassman, Susanne Kessler, Jihee Kim, Timothy O. Cox, Oxana Dmitrieva-Posocco, Andrea C. Wong, Erik L. Allman, Soumita Ghosh, Nitika Sharma, Kasturi Sengupta, Belinda Cornes, Nitai Dean, Gary A. Churchill, Tejvir S. Khurana, Mark A. Sellmyer, Garret A. FitzGerald, Andrew D. Patterson, Joseph A. Baur, Amber L. Alhadeff, Eric J.N. Helfrich, Maayan Levy, J. Nicholas Betley, Christoph A. Thaiss, 2022, Nature on p. 739-747

Genetic differences in nicotine sensitivity and metabolism in C57BL/6J and NOD/ShiLtJ mouse strains

Laurel R. Seemiller, Lisa R. Goldberg, Phillip B. Smith, Jason Dennis, Andrew David Patterson, Thomas J. Gould, 2022, Neuropharmacology

Ahmed Dawood Mohammed, Zahraa Mohammed, Mary M. Roland, Ioulia Chatzistamou, Amy Jolly, Lillian M. Schoettmer, Mireya Arroyo, Khadija Kakar, Yuan Tian, Andrew Patterson, Mitzi Nagarkatti, Prakash Nagarkatti, Jason L. Kubinak, 2022, Nature Communications

The unfolded protein response gene Ire1α is required for tissue renewal and normal differentiation in the mouse tongue and esophagus

Fiona E. Chalmers, Saie Mogre, Bipin Rimal, Jeongin Son, Andrew D. Patterson, Douglas B. Stairs, Adam B. Glick, 2022, Developmental Biology on p. 59-70

Jeffry C. Granados, Kian Falah, Imhoi Koo, Ethan W. Morgan, Gary H. Perdew, Andrew David Patterson, Neema Jamshidi, Sanjay K. Nigam, 2022, Scientific Reports

Jie Jiang, Yuandi Ma, Yameng Liu, Dasheng Lu, Xiaoxia Gao, Kristopher W. Krausz, Dhimant Desai, Shantu G. Amin, Andrew D. Patterson, Frank J. Gonzalez, Cen Xie, 2022, Hepatology Communications on p. 3363-3378

C. Matamoros, F. Hao, Y. Tian, A. D. Patterson, K. J. Harvatine, 2022, Journal of Dairy Science on p. 8824-8838

Bandar D. Alrehaili, Mikang Lee, Shogo Takahashi, Robert Novak, Bipin Rimal, Shannon Boehme, Samuel A.J. Trammell, Trisha J. Grevengoed, Devendra Kumar, Yazen Alnouti, Katya Chiti, Xinwen Wang, Andrew D. Patterson, John Y.L. Chiang, Frank J. Gonzalez, Yoon Kwang Lee, 2022, Hepatology Communications on p. 2765-2780

Yuan Tian, Bipin Rimal, Wei Gui, Imhoi Koo, Philip B. Smith, Shigetoshi Yokoyama, Andrew D. Patterson, 2022, Metabolites

Most-Cited Papers

Iain A. Murray, Andrew D. Patterson, Gary H. Perdew, 2014, Nature Reviews Cancer on p. 801-814

Fei Li, Changtao Jiang, Kristopher W. Krausz, Yunfei Li, Istvan Albert, Haiping Hao, Kristin M. Fabre, James B. Mitchell, Andrew D. Patterson, Frank J. Gonzalez, 2013, Nature Communications

Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402

Lulu Sun, Cen Xie, Guang Wang, Yue Wu, Qing Wu, Xuemei Wang, Jia Liu, Yangyang Deng, Jialin Xia, Bo Chen, Songyang Zhang, Chuyu Yun, Guan Lian, Xiujuan Zhang, Heng Zhang, William H. Bisson, Jingmin Shi, Xiaoxia Gao, Pupu Ge, Cuihua Liu, Kristopher W. Krausz, Robert G. Nichols, Jingwei Cai, Bipin Rimal, Andrew D. Patterson, Xian Wang, Frank J. Gonzalez, Changtao Jiang, 2018, Nature Medicine on p. 1919-1929

Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu G. Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez, 2015, Nature Communications

G Li, C Xie, S Lu, R Nichols, Yuan Tian, L Li, D Patel, Y Ma, C Brocker, T Yan, K Krausz, R Xiang, O Gavrilova, Andrew D. Patterson, F Gonzalez, 2017, Cell Metabolism on p. 672-685.e4

P Pathak, C Xie, R Nichols, J Ferrell, S Boehme, K Krausz, Andrew D. Patterson, F Gonzalez, Chiang JYL, John Y.L. Chiang, 2018, Hepatology on p. 1574-1588

Vishal Singh, Beng San Yeoh, Benoit Chassaing, Xia Xiao, Piu Saha, Rodrigo Aguilera Olvera, John D. Lapek, Limin Zhang, Wei Bei Wang, Sijie Hao, Michael D. Flythe, David J. Gonzalez, Patrice D. Cani, Jose R. Conejo-Garcia, Na Xiong, Mary J. Kennett, Bina Joe, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2018, Cell on p. 679-694.e22

Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Health Perspectives on p. 679-688

Frank J. Gonzalez, Changtao Jiang, Andrew D. Patterson, 2016, Gastroenterology on p. 845-859

News Articles Featuring Andrew Patterson

Broccoli consumption protects gut lining, reduces disease, in mice

Broccoli is known to be beneficial to our health. For example, research has shown that increased consumption of the cruciferous vegetable decreases incidences of cancer and type 2 diabetes.

Two College of Ag Sciences faculty among highly cited researchers in 2022

Andrew Patterson and Jonathan Lynch in Penn State’s College of Agricultural Sciences were recognized recently as highly cited researchers by the Clarivate Analytics Web of Science Group.

Microbiome Center announces inaugural Interdisciplinary Innovation Fellows

The Penn State Microbiome Center has named six recipients for its inaugural Interdisciplinary Innovation Fellowships (IIF) program, which aims to promote collaborative training opportunities for center members.

Metabolomics Core Facility continues to expand while pushing scientific bounds

Established nearly a decade ago, Penn State’s Metabolomics Core Facility is housed in the Huck Institutes of the Life Sciences on the University Park campus.

Andrew Patterson receives Society of Toxicology Achievement Award

The Society of Toxicology has named Tombros Early Career Professor Andrew Patterson of Penn State as the recipient of its 2021 Achievement Award, recognizing his significant contributions to the field of toxicology within 15 years of obtaining the highest earned degree.

Listening to your gut: A powerful new tool on the microbiome and cell metabolism

Many aspects of our lives — not only the presence or absence of certain diseases, but conditions like obesity, sleep patterns, even mood — may be determined, to a surprising extent, by the microbes living inside of us.

Persistent environmental contaminant changes the gut microbiome of mice

An industrial chemical — phased out since 2002, but previously used in stain and water-repellent products and firefighting foam — alters the gut microbiome of mice and could have implications for human health, according to an international team of researchers.