Andrew Patterson

Associate Director, Huck Institutes of the Life Sciences; Professor and Huck Chair of Molecular Toxicology; Faculty Oversight, Metabolomics Core Facility

Andrew Patterson

Research Summary

The Patterson lab is focused on understanding the host-metabolite-microbiome axis

Huck Graduate Students

Huck Affiliations

Links

Most Recent Publications

Xenobiotic Receptor-Mediated Toxicity

GH Perdew, IA Murray, JM Peters,

Almond snacking modulates gut microbiome and metabolome in association with improved cardiometabolic and inflammatory markers

Gwoncheol Park, Katelyn Johnson, Katelyn Miller, Saurabh Kadyan, Saiful Singar, Cole Patoine, Fuhua Hao, Yujin Lee, Andrew D. Patterson, Bahram Arjmandi, Penny Margaret Kris-Etherton, Claire E. Berryman, Ravinder Nagpal, 2025, npj Science of Food

Differential hepatic activation of mouse and human peroxisome proliferator-activated receptor-α by perfluorohexane sulfonate

Yahya Khan, Annalee M. Schmidt, Kyle J. Oldro, Xiaoyang Zhu, Angelina R. Kramer, Sarah R. Hamilton, Katherine O. Bleil, Ryan M. Krisko, Jeremiah D. Zitzow, Yuan Tian, Shu Ching Chang, Vonn Walter, Samuel M. Cohen, Frank J. Gonzalez, Andrew D. Patterson, Jeffrey M. Peters, 2025, Toxicological Sciences on p. 47-52

Discovery of metabolites prevails amid in-source fragmentation

Yasin El Abiead, Adriano Rutz, Simone Zuffa, Bashar Amer, Shipei Xing, Corinna Brungs, Robin Schmid, Mario S.P. Correia, Andres Mauricio Caraballo-Rodriguez, Amir Zarrinpar, Helena Mannochio-Russo, Michael Witting, Ipsita Mohanty, Tomáš Pluskal, Wout Bittremieux, Rob Knight, Andrew D. Patterson, Justin J.J. van der Hooft, Sebastian Böcker, Warwick B. Dunn, Roger G. Linington, David S. Wishart, Jean Luc Wolfender, Oliver Fiehn, Nicola Zamboni, Pieter C. Dorrestein, 2025, Nature Metabolism on p. 435-437

Phytochemical-Mediated Ah Receptor Activity Is Dependent on Dietary Context

Fangcong Dong, Andrew J. Annalora, Iain A. Murray, Debopriya Chakraborty, Denise M. Coslo, Craig Marcus, Andrew D. Patterson, Gary H. Perdew, 2025, Nutrients

Immunobiology of bile and cholangiocytes

Y Li, P Leung, W Zhang, S Zhang, Z Liu, M Kurth, Andrew Patterson, M Gershwin, J Song, 2025, Journal of Autoimmunity on p. 103376

In vitro microbiota model recapitulates and predicts individualised sensitivity to dietary emulsifier

H Rytter, S Naimi, G Wu, J Lewis, M Duquesnoy, L Vigué, O Tenaillon, E Belda, M Vazquez-Gomez, N Touly, D Arnone, F Hao, R Ley, K Clément, L Peyrin-Biroulet, Andrew Patterson, A Gewirtz, B Chassaing, 2025, Gut

Microbiota and metabolite-based prediction tool for colonic polyposis with and without a known genetic driver

Bryson W. Katona, Ashutosh Shukla, Weiming Hu, Thomas Nyul, Christina Dudzik, Alex Arvanitis, Daniel Clay, Michaela Dungan, Marina Weber, Vincent Tu, Fuhua Hao, Shuheng Gan, Lillian Chau, Anna M. Buchner, Gary W. Falk, David L. Jaffe, Gregory Ginsberg, Suzette N. Palmer, Xiaowei Zhan, Andrew D. Patterson, Kyle Bittinger, Josephine Ni, 2025, Gut Microbes

Individualized microbiotas dictate the impact of dietary fiber on colitis sensitivity

Erica Bonazzi, Alexis Bretin, Lucile Vigué, Fuhua Hao, Andrew D. Patterson, Andrew T. Gewirtz, Benoit Chassaing, 2024, Microbiome

Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma

Nneka E. Mbah, Amy L. Myers, Peter Sajjakulnukit, Chan Chung, Joyce K. Thompson, Hanna S. Hong, Heather Giza, Derek Dang, Zeribe C. Nwosu, Mengrou Shan, Stefan R. Sweha, Daniella D. Maydan, Brandon Chen, Li Zhang, Brian Magnuson, Zirui Zhu, Megan Radyk, Brooke Lavoie, Viveka Nand Yadav, Imhoi Koo, Andrew D. Patterson, Daniel R. Wahl, Luigi Franchi, Sameer Agnihotri, Carl J. Koschmann, Sriram Venneti, Costas A. Lyssiotis, 2024, Nature Communications

Most-Cited Papers

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Lulu Sun, Cen Xie, Guang Wang, Yue Wu, Qing Wu, Xuemei Wang, Jia Liu, Yangyang Deng, Jialin Xia, Bo Chen, Songyang Zhang, Chuyu Yun, Guan Lian, Xiujuan Zhang, Heng Zhang, William H. Bisson, Jingmin Shi, Xiaoxia Gao, Pupu Ge, Cuihua Liu, Kristopher W. Krausz, Robert G. Nichols, Jingwei Cai, Bipin Rimal, Andrew D. Patterson, Xian Wang, Frank J. Gonzalez, Changtao Jiang, 2018, Nature Medicine on p. 1919-1929

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402

Bile acids and the gut microbiota: metabolic interactions and impacts on disease

S Collins, Jonathan Stine, Jordan E. Bisanz, C. Denise Okafor, D Okafor, Andrew Patterson, 2022, Nature Reviews Microbiology on p. 236-247

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota

G Li, C Xie, S Lu, R Nichols, Yuan Tian, L Li, D Patel, Y Ma, C Brocker, T Yan, K Krausz, R Xiang, O Gavrilova, Andrew D. Patterson, F Gonzalez, 2017, Cell Metabolism on p. 672-685.e4

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu G. Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez, 2015, Nature Communications

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

P Pathak, C Xie, R Nichols, J Ferrell, S Boehme, K Krausz, Andrew D. Patterson, F Gonzalez, Chiang JYL, John Y.L. Chiang, 2018, Hepatology on p. 1574-1588

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

Vishal Singh, Beng San Yeoh, Benoit Chassaing, Xia Xiao, Piu Saha, Rodrigo Aguilera Olvera, John D. Lapek, Limin Zhang, Wei Bei Wang, Sijie Hao, Michael D. Flythe, David J. Gonzalez, Patrice D. Cani, Jose R. Conejo-Garcia, Na Xiong, Mary J. Kennett, Bina Joe, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2018, Cell on p. 679-694.e22

Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells

Qi Yan Ang, Margaret Alexander, John C. Newman, Yuan Tian, Jingwei Cai, Vaibhav Upadhyay, Jessie A. Turnbaugh, Eric Verdin, Kevin D. Hall, Rudolph L. Leibel, Eric Ravussin, Michael Rosenbaum, Andrew D. Patterson, Peter J. Turnbaugh, 2020, Cell on p. 1263-1275.e16

An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease

Frank J. Gonzalez, Changtao Jiang, Andrew D. Patterson, 2016, Gastroenterology on p. 845-859

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific Reports

News Articles Featuring Andrew Patterson

Jun 24, 2025

Ten interdisciplinary research teams awarded IEE seed grants

Ten interdisciplinary research teams have received funding through the Institute of Energy and the Environment’s (IEE) 2025 Seed Grant Program.

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Mar 03, 2025

Synthetic microbiome therapy suppresses bacterial infection without antibiotics

Precise, targeted treatment using limited strains of gut bacteria effectively protected against C. difficile infection, severe symptoms and recurrent infections in mice.

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Mar 03, 2025

'Growing Impact' discusses environmental contaminants, human health

The latest episode of Growing Impact discusses how environmental contaminants affect human health, a research focus for Penn State professors Andrew Patterson and Costas Maranas.

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Dec 09, 2024

The stories that defined 2024 for the One Health Microbiome Center at Penn State

The One Health Microbiome Center has grown, and 2024’s most popular articles below highlight the determination and innovative research by Center members in the gut microbiome, nutritional sciences, food science and agriculture, in addition to headlines featuring partnerships and internships paving the way for future success.

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Sep 09, 2024

Refined dietary fiber may increase risk for inflammatory bowel disease

New research in mice suggests that guar gum powder — a common dietary fiber additive used in processed foods — may negatively change gut microbiome and increase risk of developing inflammatory bowel disease.

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Aug 14, 2024

Early life exposure to common chemical permanently disrupts gut microbiome

Early life exposure to "forever chemicals" in the environment permanently disrupts the gut microbiome in mice, contributing to the development of metabolic disease in later life, according to a new study led by Penn State researchers. The results suggest that human exposure to these chemicals during early childhood may be contributing to the recent epidemic of metabolic disorders, including obesity and Type 2 diabetes among adults.

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Feb 28, 2024

New tech harvests both magnetic and ultrasound energy to safely power medical implants

Researchers have developed an innovative dual energy harvesting technology that combines magnetic field and ultrasonic energy, their generating 300% higher power than the current state-of-the-art devices

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Feb 28, 2024

New role for bacterial enzyme in gut metabolism revealed

Bile acids long have been known to play a role in human metabolism. Synthesized from cholesterol in the liver, bile acids are involved in digestive processes, particularly in absorbing fat.

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Feb 20, 2024

Dual-energy harvesting device could power future wireless medical implants

A new wireless charging device developed by Penn State scientists could dramatically improve powering capability for implants while still being safe for our bodies, the researchers said.

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Jan 05, 2024

The stories that defined 2023 for the One Health Microbiome Center

A list of the top 10 most popular Penn State News articles about the One Health Microbiome Center

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Nov 21, 2023

College of Ag Sciences recognizes faculty, staff for research achievements

Penn State’s College of Agricultural Sciences lauded outstanding accomplishments in research during the 2023 Research Awards Ceremony, held Nov. 1 at the Hintz Family Alumni Center on the University Park campus.

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Aug 09, 2023

College of Ag Sciences scientist receives grant to study gut homeostasis, diet

Can plants evolved to resist infection help humans do the same?

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Jul 19, 2023

Penn State researchers examine how environmental chemicals affect gut microbiome

Worldwide, high rates of obesity and other inflammatory conditions are associated with increased risk for cancer, cardiovascular disease and type 2 diabetes.

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Apr 06, 2023

Broccoli consumption protects gut lining, reduces disease, in mice

Broccoli is known to be beneficial to our health. For example, research has shown that increased consumption of the cruciferous vegetable decreases incidences of cancer and type 2 diabetes.

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Jan 12, 2023

Two College of Ag Sciences faculty among highly cited researchers in 2022

Andrew Patterson and Jonathan Lynch in Penn State’s College of Agricultural Sciences were recognized recently as highly cited researchers by the Clarivate Analytics Web of Science Group.

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Sep 13, 2022

Microbiome Center announces inaugural Interdisciplinary Innovation Fellows

The Penn State Microbiome Center has named six recipients for its inaugural Interdisciplinary Innovation Fellowships (IIF) program, which aims to promote collaborative training opportunities for center members.

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Sep 02, 2022

Metabolomics Core Facility continues to expand while pushing scientific bounds

Established nearly a decade ago, Penn State’s Metabolomics Core Facility is housed in the Huck Institutes of the Life Sciences on the University Park campus.

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Feb 09, 2021

Andrew Patterson receives Society of Toxicology Achievement Award

The Society of Toxicology has named Tombros Early Career Professor Andrew Patterson of Penn State as the recipient of its 2021 Achievement Award, recognizing his significant contributions to the field of toxicology within 15 years of obtaining the highest earned degree.

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Mar 11, 2020

Listening to your gut: A powerful new tool on the microbiome and cell metabolism

Many aspects of our lives — not only the presence or absence of certain diseases, but conditions like obesity, sleep patterns, even mood — may be determined, to a surprising extent, by the microbes living inside of us.

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Jan 21, 2020

Persistent environmental contaminant changes the gut microbiome of mice

An industrial chemical — phased out since 2002, but previously used in stain and water-repellent products and firefighting foam — alters the gut microbiome of mice and could have implications for human health, according to an international team of researchers.

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