Andrew Patterson

Professor and Huck Chair of Molecular Toxicology

322 Huck Life Sciences
University Park, PA
adp117@psu.edu
814-867-4565

Research Summary

The Patterson lab is focused on understanding the host-metabolite-microbiome axis

Huck Affiliations

Publication Tags

Metabolomics Microbiota Obesity Bile Acids And Salts Parasites Aryl Hydrocarbon Receptors Hydrocarbons Metabolites Liver Metabolism Intestines Homeostasis Gastrointestinal Microbiome Glucose Glycine Muricholic Acid Biomarkers Xenobiotics Tempol Acids Fungi Fatty Acids Ions Muscles Radiation

Most Recent Papers

The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2

Lei Bao, Fernanda Festa, Christopher S. Freet, John P. Lee, Iwona M. Hirschler-Laszkiewicz, Shu jen Chen, Kerry A. Keefer, Hong Gang Wang, Andrew D. Patterson, Joseph Y. Cheung, Barbara A. Miller, 2019, Scientific reports

Specialist and generalist fungal parasites induce distinct biochemical changes in the mandible muscles of their host

Shanshan Zheng, Raquel Loreto, Philip Smith, Andrew Patterson, David Hughes, Liande Wang, 2019, International journal of molecular sciences

Nutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass

D. Nyasha Chagwedera, Qi Yan Ang, Jordan E. Bisanz, Yew Ann Leong, Kirthana Ganeshan, Jingwei Cai, Andrew David Patterson, Peter J. Turnbaugh, Ajay Chawla, 2019, Cell Metabolism on p. 364-373.e7

Gender differences in phytoestrogens and the relationship with speed of processing in older adults

Jessie Alwerdt, Andrew D. Patterson, Martin J. Sliwinski, 2019, Nutrients

Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche

Siyang Hao, Jie Xiang, Dai Chen Wu, James W. Fraser, Baiye Ruan, Jingwei Cai, Andrew D. Patterson, Zhi Chun Lai, Robert F. Paulson, 2019, Blood Advances on p. 2205-2217

Evaluating the structural complexity of isomeric bile acids with ion mobility spectrometry

Xueyun Zheng, Francesca B. Smith, Noor A. Aly, Jingwei Cai, Richard D. Smith, Andrew David Patterson, Erin S. Baker, 2019, Analytical and Bioanalytical Chemistry on p. 4673-4682

Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus)

Yuan Tian, Wei Gui, Philip B. Smith, Imhoi Koo, Iain A. Murray, Margherita T. Cantorna, Gary H. Perdew, Andrew D. Patterson, 2019, Journal of agricultural and food chemistry on p. 9286-9294

Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline

Troy D. Hubbard, Qing Liu, Iain A. Murray, Fangcong Dong, Charles Miller, Philip B. Smith, Krishne Gowda, Jyh Ming Lin, Shantu Amin, Andrew D. Patterson, Gary H. Perdew, 2019, Journal of Proteome Research on p. 1715-1724

Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism

Fengming Chen, Denise M. Coslo, Tao Chen, Limin Zhang, Yuan Tian, Philip B. Smith, Andrew D. Patterson, Curtis J. Omiecinski, 2019, Journal of Proteome Research on p. 239-251

Vitamin D Regulates the Microbiota to Control the Numbers of RORγt/FoxP3+ Regulatory T Cells in the Colon

Margherita T. Cantorna, Yang Ding Lin, Juhi Arora, Stephanie Bora, Yuan Tian, Robert G. Nichols, Andrew D. Patterson, 2019, Frontiers in immunology

Most-Cited Papers

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

Fei Li, Changtao Jiang, Kristopher W. Krausz, Yunfei Li, Istvan Albert, Haiping Hao, Kristin M. Fabre, James B. Mitchell, Andrew D. Patterson, Frank J. Gonzalez, 2013, Nature communications

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu G. Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez, 2015, Nature communications

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis

Naoki Tanaka, Tsutomu Matsubara, Kristopher W. Krausz, Andrew D. Patterson, Frank J. Gonzalez, 2012, Hepatology on p. 118-129

Xenobiotic metabolomics

Caroline H. Johnson, Andrew D. Patterson, Jeffrey R. Idle, Frank J. Gonzalez, 2012, Annual Review of Pharmacology and Toxicology on p. 37-56

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental health perspectives on p. 679-688

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific reports

Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity

Andrew D. Patterson, Yatrik M. Shah, Tsutomu Matsubara, Kristopher W. Krausz, Frank J. Gonzalez, 2012, Hepatology on p. 281-290

Radiation metabolomics. 4. UPLC-ESI-QTOFMS-based metabolomics for urinary biomarker discovery in gamma-irradiated rats

Caroline H. Johnson, Andrew D. Patterson, Kristopher W. Krausz, Christian Lanz, Dong Wook Kang, Hans Luecke, Frank J. Gonzalez, Jeffrey R. Idle, 2011, Radiation research on p. 473-484

Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer

Ewy A. Mathé, Andrew D. Patterson, Majda Haznadar, Soumen K. Manna, Kristopher W. Krausz, Elise D. Bowman, Peter G. Shields, Jeffrey R. Idle, Philip B. Smith, Katsuhiro Anami, Dickran G. Kazandjian, Emmanuel Hatzakis, Frank J. Gonzalez, Curtis C. Harris, 2014, Cancer Research on p. 3259-3270

News Articles Featuring Andrew Patterson

Mar 11, 2020

Listening to your gut: A powerful new tool on the microbiome and cell metabolism

Many aspects of our lives — not only the presence or absence of certain diseases, but conditions like obesity, sleep patterns, even mood — may be determined, to a surprising extent, by the microbes living inside of us.

Full Article

Jan 21, 2020

Persistent environmental contaminant changes the gut microbiome of mice

An industrial chemical — phased out since 2002, but previously used in stain and water-repellent products and firefighting foam — alters the gut microbiome of mice and could have implications for human health, according to an international team of researchers.