Andrew Patterson

Professor of Molecular Toxicology

Andrew Patterson

Publication Tags

Metabolomics Glucose Gastrointestinal Microbiome Toxicity Metabolism Microbiota Mass Spectrometry Xenobiotics Liver Tempol Obesity Intestines Radiation Bile Acids And Salts Flow Cytometry Mice Physiology Biomarkers Fermentation Nuclear Magnetic Resonance Lipid Metabolism Homeostasis Amino Acids Lipids Glycine

Most Recent Papers

Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline

Troy D. Hubbard, Qing Liu, Iain Alexander Murray, Fangcong Dong, Charles Miller, Philip B. Smith, Krishne Gowda, Jyh Ming Lin, Shantu Amin, Andrew David Patterson, Gary H. Perdew, 2019, Journal of Proteome Research on p. 1715-1724

Berberine directly affects the gut microbiota to promote intestinal farnesoid X receptor activation

Yuan Tian, Jingwei Cai, Wei Gui, Robert G. Nichols, Imhoi Koo, Jingtao Zhang, Mallappa Anitha, Andrew David Patterson, 2019, Drug Metabolism and Disposition on p. 86-93

Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism

Fengming Chen, Denise M. Coslo, Tao Chen, Limin Zhang, Yuan Tian, Philip B. Smith, Andrew David Patterson, Curtis John Omiecinski, 2019, Journal of Proteome Research on p. 239-251

Retinoic acid mediated clearance of Citrobacter rodentium in vitamin A deficient mice requires CD11b+ and T cells

Lindsay M. Snyder, Kaitlin L. McDaniel, Yuan Tian, Cheng Hsin Wei, Mary J. Kennett, Andrew David Patterson, A. Catharine Ross, Margherita Teresa-Anna Cantorna, 2019, Frontiers in immunology

Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation

Vishal Singh, Beng San Yeoh, Rachel E. Walker, Xia Xiao, Piu Saha, Rachel M. Golonka, Jingwei Cai, Alexis Charles Andre Bretin, Xi Cheng, Qing Liu, Michael D. Flythe, Benoit Chassaing, Gregory C. Shearer, Andrew David Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2019, Gut

Multiplatform physiologic and metabolic phenotyping reveals microbial toxicity

Jingwei Cai, Robert G. Nichols, Imhoi Koo, Zachary A. Kalikow, Limin Zhang, Yuan Tian, Jingtao Zhang, Philip B. Smith, Andrew David Patterson, 2018, mSystems

Structural and Functional Analysis of the Gut Microbiome for Toxicologists

Robert G. Nichols, Jingwei Cai, Iain Alexander Murray, Imhoi Koo, Philip B. Smith, Gary H. Perdew, Andrew David Patterson, 2018, Current Protocols in Toxicology

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

Vishal Singh, Beng San Yeoh, Benoit Chassaing, Xia Xiao, Piu Saha, Rodrigo Aguilera Olvera, John D. Lapek, Limin Zhang, Wei-bei Wang, Sijie Hao, Michael D. Flythe, David J. Gonzalez, Patrice D. Cani, Jose R. Conejo-Garcia, Na Xiong, Mary J. Kennett, Bina Joe, Andrew David Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2018, Cell on p. 679-694.e22

Lipid metabolism and lipophagy in cancer

Meenu Maan, Jeffrey Maurice Peters, Mainak Dutta, Andrew David Patterson, 2018, Biochemical and Biophysical Research Communications on p. 582-589

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

Preeti Pathak, Cen Xie, Robert G. Nichols, Jessica M. Ferrell, Shannon Boehme, Kristopher W. Krausz, Andrew David Patterson, Frank J. Gonzalez, John Y.L. Chiang, 2018, Hepatology on p. 1574-1588

High-Impact Papers

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

Fei Li, Changtao Jiang, Kristopher W. Krausz, Yunfei Li, Istvan Albert, Haiping Hao, Kristin M. Fabre, James B. Mitchell, Andrew David Patterson, Frank J. Gonzalez, 2013, Nature communications

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu Amin, Istvan Albert, Andrew David Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402

Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling

Andrew David Patterson, Olivier Maurhofer, Diren Beyoǧlu, Christian Lanz, Kristopher W. Krausz, Thomas Pabst, Frank J. Gonzalez, Jean François Dufour, Jeffrey R. Idle, 2011, Cancer Research on p. 6590-6600

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew David Patterson, Frank J. Gonzalez, 2015, Nature communications

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis

Naoki Tanaka, Tsutomu Matsubara, Kristopher W. Krausz, Andrew David Patterson, Frank J. Gonzalez, 2012, Hepatology on p. 118-129

Xenobiotic metabolomics

Caroline H. Johnson, Andrew David Patterson, Jeffrey R. Idle, Frank J. Gonzalez, 2012, Annual Review of Pharmacology and Toxicology on p. 37-56

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Limin Zhang, Robert G. Nichols, Jared Correll, Iain Alexander Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew David Patterson, 2015, Environmental health perspectives on p. 679-688

Radiation metabolomics. 2. dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice

John B. Tyburski, Andrew David Patterson, Kristopher W. Krausz, Josef Slavk, Albert J. Fornace, Frank J. Gonzalez, Jeffrey R. Idle, 2009, Radiation research on p. 42-57

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Troy D. Hubbard, Iain Alexander Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu Amin, Andrew David Patterson, Gary H. Perdew, 2015, Scientific reports

Radiation Metabolomics. 3. Biomarker Discovery in the Urine of Gamma-Irradiated Rats Using a Simplified Metabolomics Protocol of Gas Chromatography-Mass Spectrometry Combined with Random Forests Machine Learning Algorithm

Christian Lanz, Andrew David Patterson, Josef Slavk, Kristopher W. Krausz, Monika Ledermann, Frank J. Gonzalez, Jeffrey R. Idle, 2009, Radiation research on p. 198-212