Andrew Patterson

Professor and Huck Chair of Molecular Toxicology; Faculty Oversight, Metabolomics Core Facility

Andrew Patterson

Research Summary

The Patterson lab is focused on understanding the host-metabolite-microbiome axis

Huck Affiliations


Publication Tags

Gastrointestinal Microbiome Ligands Obesity Bile Acids And Salts Liver Microbiota Hydrocarbons Non Alcoholic Fatty Liver Disease Mice Intestines Metformin Ursodeoxycholic Acid Aryl Hydrocarbon Receptors Metabolomics Glycine Muricholic Acid Saccharin Homeostasis Tempol Fermentation Selenium Trichlorosucrose Drosophila Melanogaster Metabolism Serum

Most Recent Papers

Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation

Renuka R. Nayak, Margaret Alexander, Ishani Deshpande, Kye Stapleton-Gray, Bipin Rimal, Andrew D. Patterson, Carles Ubeda, Jose U. Scher, Peter J. Turnbaugh, 2021, Cell Host and Microbe on p. 362-377.e11

Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice

Jenessa A. Winston, Alissa Rivera, Jingwei Cai, Andrew D. Patterson, Casey M. Theriot, 2021, PLoS One

Impaired intestinal akkermansia muciniphila and aryl hydrocarbon receptor ligands contribute to nonalcoholic fatty liver disease in mice

Zunji Shi, Hehua Lei, Gui Chen, Peihong Yuan, Zheng Cao, Hooi Leng Ser, Xuehang Zhu, Fang Wu, Caixiang Liu, Manyuan Dong, Yuchen Song, Yangyang Guo, Chuan Chen, Kexin Hu, Yifan Zhu, Xin An Zeng, Jinlin Zhou, Yujing Lu, Andrew D. Patterson, Limin Zhang, 2021, mSystems

Selenium-dependent metabolic reprogramming during inflammation and resolution

Arvind M. Korwar, Ayaan Hossain, Tai Jung Lee, Ashley E. Shay, Venkatesha Basrur, Kevin Conlon, Philip B. Smith, Bradley A. Carlson, Howard M. Salis, Andrew D. Patterson, K. Sandeep Prabhu, 2021, Journal of Biological Chemistry

Sample preparation and data analysis for NMR-based metabolomics

Tapas K. Mal, Yuan Tian, Andrew D. Patterson, 2021, on p. 301-313

Quantitative analysis of bile acid with UHPLC-MS/MS

Yuan Tian, Jingwei Cai, Erik L. Allman, Philip B. Smith, Andrew D. Patterson, 2021, on p. 291-300

Exercise Training Reverses Gut Dysbiosis in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis

Alexa Hughes, Jessica Dahmus, Gloriany Rivas, Breianna Hummer, Jeremy R. Chen See, Justin R. Wright, Regina Lamendella, Kathryn H. Schmitz, Christopher Sciamanna, Mack Ruffin, Andrew D. Patterson, Rohit Loomba, Jonathan G. Stine, 2021, Clinical Gastroenterology and Hepatology

A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance

Kevin Man, Christopher Bowman, Kristina N. Braverman, Veronica Escalante, Yuan Tian, Jordan E. Bisanz, Kirthana Ganeshan, Biao Wang, Andrew Patterson, James R. Bayrer, Peter J. Turnbaugh, Ajay Chawla, 2020, Proceedings of the National Academy of Sciences of the United States of America on p. 32029-32037

How gut microbiome interactions affect nutritional traits of Drosophila melanogaster

John G. McMullen, Grace Peters-Schulze, Jingwei Cai, Andrew D. Patterson, Angela E. Douglas, 2020, Journal of Experimental Biology

Exercise Training Reverses Gut Dysbiosis in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis: A Proof of Concept Study.

A Hughes, J Dahmus, G Rivas, B Hummer, J Chen See, J Wright, R Lamendella, K Schmitz, C Sciamanna, M Ruffin, Andrew Patterson, R Loomba, J Stine, 2020, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Most-Cited Papers

Aryl hydrocarbon receptor ligands in cancer

Iain A. Murray, Andrew D. Patterson, Gary H. Perdew, 2014, Nature Reviews Cancer on p. 801-814

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

Fei Li, Changtao Jiang, Kristopher W. Krausz, Yunfei Li, Istvan Albert, Haiping Hao, Kristin M. Fabre, James B. Mitchell, Andrew D. Patterson, Frank J. Gonzalez, 2013, Nature Communications

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu G. Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez, 2015, Nature Communications

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Lulu Sun, Cen Xie, Guang Wang, Yue Wu, Qing Wu, Xuemei Wang, Jia Liu, Yangyang Deng, Jialin Xia, Bo Chen, Songyang Zhang, Chuyu Yun, Guan Lian, Xiujuan Zhang, Heng Zhang, William H. Bisson, Jingmin Shi, Xiaoxia Gao, Pupu Ge, Cuihua Liu, Kristopher W. Krausz, Robert G. Nichols, Jingwei Cai, Bipin Rimal, Andrew D. Patterson, Xian Wang, Frank J. Gonzalez, Changtao Jiang, 2018, Nature Medicine on p. 1919-1929

Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling

Andrew David Patterson, Olivier Maurhofer, Diren Beyoǧlu, Christian Lanz, Kristopher W. Krausz, Thomas Pabst, Frank J. Gonzalez, Jean François Dufour, Jeffrey R. Idle, 2011, Cancer Research on p. 6590-6600

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Health Perspectives on p. 679-688

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis

Naoki Tanaka, Tsutomu Matsubara, Kristopher W. Krausz, Andrew D. Patterson, Frank J. Gonzalez, 2012, Hepatology on p. 118-129

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota

Guolin Li, Cen Xie, Siyu Lu, Robert G. Nichols, Yuan Tian, Licen Li, Daxeshkumar Patel, Yinyan Ma, Chad N. Brocker, Tingting Yan, Kristopher W. Krausz, Rong Xiang, Oksana Gavrilova, Andrew David Patterson, Frank J. Gonzalez, 2017, Cell Metabolism on p. 672-685.e4

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific Reports