Andrew Patterson

Professor and Huck Chair of Molecular Toxicology; Faculty Oversight, Metabolomics Core Facility

Andrew Patterson

Research Summary

The Patterson lab is focused on understanding the host-metabolite-microbiome axis

Huck Graduate Students

Huck Affiliations


Publication Tags

Gastrointestinal Microbiome Liver Bile Acids And Salts Obesity Ligands Microbiota Intestines Non Alcoholic Fatty Liver Disease Aryl Hydrocarbon Receptors Mice Metabolic Metformin Ursodeoxycholic Acid Hydrocarbon Hydrocarbons Glycine Muricholic Acid Saccharin Therapeutics Homeostasis Tempol Fermentation Ceramides Bile Acid Diet

Most Recent Papers

The east asian gut microbiome is distinct from colocalized white subjects and connected to metabolic health

Qi Yan Ang, Diana L. Alba, Vaibhav Upadhyay, Jordan E. Bisanz, Jingwei Cai, Ho Lim Lee, Eliseo Barajas, Grace Wei, Cecilia Noecker, Andrew D. Patterson, Suneil K. Koliwad, Peter J. Turnbaugh, 2021, eLife

Exercise Training Reverses Gut Dysbiosis in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis

Alexa Hughes, Jessica Dahmus, Gloriany Rivas, Breianna Hummer, Jeremy R. Chen See, Justin R. Wright, Regina Lamendella, Kathryn H. Schmitz, Christopher Sciamanna, Mack Ruffin, Andrew D. Patterson, Rohit Loomba, Jonathan G. Stine, 2021, Clinical Gastroenterology and Hepatology on p. 1723-1725

Caloric restriction disrupts the microbiota and colonization resistance

Reiner Jumpertz von Schwartzenberg, Jordan E. Bisanz, Svetlana Lyalina, Peter Spanogiannopoulos, Qi Yan Ang, Jingwei Cai, Sophia Dickmann, Marie Friedrich, Su Yang Liu, Stephanie L. Collins, Danielle Ingebrigtsen, Steve Miller, Jessie A. Turnbaugh, Andrew D. Patterson, Katherine S. Pollard, Knut Mai, Joachim Spranger, Peter J. Turnbaugh, 2021, Nature on p. 272-277

The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis

Qing Liu, Limin Zhang, Erik L. Allman, Troy D. Hubbard, Iain A. Murray, Fuhua Hao, Yuan Tian, Wei Gui, Robert G. Nichols, Philip B. Smith, Mallappa Anitha, Gary H. Perdew, Andrew D. Patterson, 2021, Toxicology

The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis

Alejandro Artacho, Sandrine Isaac, Renuka Nayak, Alejandra Flor-Duro, Margaret Alexander, Imhoi Koo, Julia Manasson, Philip B. Smith, Pamela Rosenthal, Yamen Homsi, Percio Gulko, Javier Pons, Leonor Puchades-Carrasco, Peter Izmirly, Andrew Patterson, Steven B. Abramson, Antonio Pineda-Lucena, Peter J. Turnbaugh, Carles Ubeda, Jose U. Scher, 2021, Arthritis and Rheumatology on p. 931-942

Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation

Renuka R. Nayak, Margaret Alexander, Ishani Deshpande, Kye Stapleton-Gray, Bipin Rimal, Andrew D. Patterson, Carles Ubeda, Jose U. Scher, Peter J. Turnbaugh, 2021, Cell Host and Microbe on p. 362-377.e11

Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice

Jenessa A. Winston, Alissa Rivera, Jingwei Cai, Andrew D. Patterson, Casey M. Theriot, 2021, PLoS One

Impaired intestinal akkermansia muciniphila and aryl hydrocarbon receptor ligands contribute to nonalcoholic fatty liver disease in mice

Zunji Shi, Hehua Lei, Gui Chen, Peihong Yuan, Zheng Cao, Hooi Leng Ser, Xuehang Zhu, Fang Wu, Caixiang Liu, Manyuan Dong, Yuchen Song, Yangyang Guo, Chuan Chen, Kexin Hu, Yifan Zhu, Xin An Zeng, Jinlin Zhou, Yujing Lu, Andrew D. Patterson, Limin Zhang, 2021, mSystems

Quantitative analysis of bile acid with UHPLC-MS/MS

Yuan Tian, Jingwei Cai, Erik L. Allman, Philip B. Smith, Andrew D. Patterson, 2021, on p. 291-300

Sample preparation and data analysis for NMR-based metabolomics

Tapas K. Mal, Yuan Tian, Andrew D. Patterson, 2021, on p. 301-313

Most-Cited Papers

Aryl hydrocarbon receptor ligands in cancer: Friend and foe

Iain A. Murray, Andrew D. Patterson, Gary H. Perdew, 2014, Nature Reviews Cancer on p. 801-814

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

Fei Li, Changtao Jiang, Kristopher W. Krausz, Yunfei Li, Istvan Albert, Haiping Hao, Kristin M. Fabre, James B. Mitchell, Andrew D. Patterson, Frank J. Gonzalez, 2013, Nature Communications

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu G. Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez, 2015, Nature Communications

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Lulu Sun, Cen Xie, Guang Wang, Yue Wu, Qing Wu, Xuemei Wang, Jia Liu, Yangyang Deng, Jialin Xia, Bo Chen, Songyang Zhang, Chuyu Yun, Guan Lian, Xiujuan Zhang, Heng Zhang, William H. Bisson, Jingmin Shi, Xiaoxia Gao, Pupu Ge, Cuihua Liu, Kristopher W. Krausz, Robert G. Nichols, Jingwei Cai, Bipin Rimal, Andrew D. Patterson, Xian Wang, Frank J. Gonzalez, Changtao Jiang, 2018, Nature Medicine on p. 1919-1929

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota

Guolin Li, Cen Xie, Siyu Lu, Robert G. Nichols, Yuan Tian, Licen Li, Daxeshkumar Patel, Yinyan Ma, Chad N. Brocker, Tingting Yan, Kristopher W. Krausz, Rong Xiang, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez, 2017, Cell Metabolism on p. 672-685.e4

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Health Perspectives on p. 679-688

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

Vishal Singh, Beng San Yeoh, Benoit Chassaing, Xia Xiao, Piu Saha, Rodrigo Aguilera Olvera, John D. Lapek, Limin Zhang, Wei Bei Wang, Sijie Hao, Michael D. Flythe, David J. Gonzalez, Patrice D. Cani, Jose R. Conejo-Garcia, Na Xiong, Mary J. Kennett, Bina Joe, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2018, Cell on p. 679-694.e22

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

Preeti Pathak, Cen Xie, Robert G. Nichols, Jessica M. Ferrell, Shannon Boehme, Kristopher W. Krausz, Andrew D. Patterson, Frank J. Gonzalez, John Y.L. Chiang, 2018, Hepatology on p. 1574-1588

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis

Naoki Tanaka, Tsutomu Matsubara, Kristopher W. Krausz, Andrew D. Patterson, Frank J. Gonzalez, 2012, Hepatology on p. 118-129