Andrew Patterson

Professor and Huck Chair of Molecular Toxicology; Faculty Oversight, Metabolomics Core Facility

Andrew Patterson

Research Summary

The Patterson lab is focused on understanding the host-metabolite-microbiome axis

Huck Graduate Students

Huck Affiliations


Publication Tags

Microbiota Metabolic Obesity Gastrointestinal Microbiome Liver Intestines Homeostasis Bile Acids And Salts Glycine Metabolomics Pharmacological Metabolism Mice Polychlorinated Biphenyls Muricholic Acid Acids Metabolism Tempol Xenobiotics Bile Acid Acid Non Alcoholic Fatty Liver Disease Environmental Pollutants Fermentation Metabolome Metformin

Most Recent Publications

Ahmed Dawood Mohammed, Zahraa Mohammed, Mary M. Roland, Ioulia Chatzistamou, Amy Jolly, Lillian M. Schoettmer, Mireya Arroyo, Khadija Kakar, Yuan Tian, Andrew Patterson, Mitzi Nagarkatti, Prakash Nagarkatti, Jason L. Kubinak, 2022, Nature Communications

Bile acid metabolism and signaling, the microbiota, and metabolic disease

Jingwei Cai, Bipin Rimal, Changtao Jiang, John Y.L. Chiang, Andrew D. Patterson, 2022, Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and on p. 108238

Yuan Tian, Bipin Rimal, Wei Gui, Imhoi Koo, Shigetoshi Yokoyama, Gary H. Perdew, Andrew D. Patterson, 2022, International Journal of Molecular Sciences

Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research

Ethan W. Morgan, Gary H. Perdew, Andrew David Patterson, 2022, Toxicological Sciences on p. 189-213

Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome

Benoit Chassaing, Charlene Compher, Brittaney Bonhomme, Qing Liu, Yuan Tian, William Walters, Lisa Nessel, Clara Delaroque, Fuhua Hao, Victoria Gershuni, Lillian Chau, Josephine Ni, Meenakshi Bewtra, Lindsey Albenberg, Alexis Bretin, Liam McKeever, Ruth E. Ley, Andrew D. Patterson, Gary D. Wu, Andrew T. Gewirtz, James D. Lewis, 2022, Gastroenterology on p. 743-756

The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice

Shengzhong Su, Laura J. Billy, Sue Chang, Frank J. Gonzalez, Andrew D. Patterson, Jeffrey M. Peters, 2022, Toxicology

D Nandy, Craig SJC, J Cai, Y Tian, I Paul, J Savage, M Marini, E Hohman, M Reimherr, Andrew Patterson, K Makova, F Chiaromonte, 2022, Pediatric obesity on p. e12833

Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice

Bandar D. Alrehaili, Mikang Lee, Shogo Takahashi, Robert Novak, Bipin Rimal, Shannon Boehme, Samuel A.J. Trammell, Trisha J. Grevengoed, Devendra Kumar, Yazen Alnouti, Katya Chiti, Xinwen Wang, Andrew D. Patterson, John Y.L. Chiang, Frank J. Gonzalez, Yoon Kwang Lee, 2022, Hepatology Communications

Reconstitution of the host holobiont in germ-free born male rats acutely increases bone growth and affects marrow cellular content

Piotr J. Czernik, Rachel M. Golonka, Saroj Chakraborty, Beng San Yeoh, Ahmed A. Abokor, Piu Saha, Ji Youn Yeo, Blair Mell, Xi Cheng, Sudipta Baroi, Yuan Tian, Andrew D. Patterson, Bina Joe, Matam Vijay-Kumar, Beata Lecka-Czernik, 2021, Physiological Genomics on p. 518-533

Most-Cited Papers

Fei Li, Changtao Jiang, Kristopher W. Krausz, Yunfei Li, Istvan Albert, Haiping Hao, Kristin M. Fabre, James B. Mitchell, Andrew D. Patterson, Frank J. Gonzalez, 2013, Nature Communications

Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402

Lulu Sun, Cen Xie, Guang Wang, Yue Wu, Qing Wu, Xuemei Wang, Jia Liu, Yangyang Deng, Jialin Xia, Bo Chen, Songyang Zhang, Chuyu Yun, Guan Lian, Xiujuan Zhang, Heng Zhang, William H. Bisson, Jingmin Shi, Xiaoxia Gao, Pupu Ge, Cuihua Liu, Kristopher W. Krausz, Robert G. Nichols, Jingwei Cai, Bipin Rimal, Andrew D. Patterson, Xian Wang, Frank J. Gonzalez, Changtao Jiang, 2018, Nature Medicine on p. 1919-1929

Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu G. Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez, 2015, Nature Communications

Vishal Singh, Beng San Yeoh, Benoit Chassaing, Xia Xiao, Piu Saha, Rodrigo Aguilera Olvera, John D. Lapek, Limin Zhang, Wei Bei Wang, Sijie Hao, Michael D. Flythe, David J. Gonzalez, Patrice D. Cani, Jose R. Conejo-Garcia, Na Xiong, Mary J. Kennett, Bina Joe, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2018, Cell on p. 679-694.e22

Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Health Perspectives on p. 679-688

Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific Reports

Naoki Tanaka, Tsutomu Matsubara, Kristopher W. Krausz, Andrew D. Patterson, Frank J. Gonzalez, 2012, Hepatology on p. 118-129

Frank J. Gonzalez, Changtao Jiang, Andrew D. Patterson, 2016, Gastroenterology on p. 845-859

Caroline H. Johnson, Andrew D. Patterson, Jeffrey R. Idle, Frank J. Gonzalez, 2012, Annual Review of Pharmacology and Toxicology on p. 37-56

News Articles Featuring Andrew Patterson

Microbiome Center announces inaugural Interdisciplinary Innovation Fellows

The Penn State Microbiome Center has named six recipients for its inaugural Interdisciplinary Innovation Fellowships (IIF) program, which aims to promote collaborative training opportunities for center members.

Metabolomics Core Facility continues to expand while pushing scientific bounds

Established nearly a decade ago, Penn State’s Metabolomics Core Facility is housed in the Huck Institutes of the Life Sciences on the University Park campus.

Andrew Patterson receives Society of Toxicology Achievement Award

The Society of Toxicology has named Tombros Early Career Professor Andrew Patterson of Penn State as the recipient of its 2021 Achievement Award, recognizing his significant contributions to the field of toxicology within 15 years of obtaining the highest earned degree.

Listening to your gut: A powerful new tool on the microbiome and cell metabolism

Many aspects of our lives — not only the presence or absence of certain diseases, but conditions like obesity, sleep patterns, even mood — may be determined, to a surprising extent, by the microbes living inside of us.

Persistent environmental contaminant changes the gut microbiome of mice

An industrial chemical — phased out since 2002, but previously used in stain and water-repellent products and firefighting foam — alters the gut microbiome of mice and could have implications for human health, according to an international team of researchers.