Andrew Patterson

Professor and Huck Chair of Molecular Toxicology; Faculty Oversight, Metabolomics Core Facility

Andrew Patterson

Research Summary

The Patterson lab is focused on understanding the host-metabolite-microbiome axis

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Gastrointestinal Microbiome Obesity Microbiota Intestines Metabolic Bile Acids And Salts Liver Homeostasis Glycine Muricholic Acid Diet Fats Acids Tempol Fermentation Health Bile Acid Mice Sodium Bicarbonate Metformin Acid Sodium Acetate Non Alcoholic Fatty Liver Disease Acetates Glucose

Most Recent Papers

Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel

Ahmed Dawood Mohammed, Zahraa Mohammed, Mary M. Roland, Ioulia Chatzistamou, Amy Jolly, Lillian M. Schoettmer, Mireya Arroyo, Khadija Kakar, Yuan Tian, Andrew Patterson, Mitzi Nagarkatti, Prakash Nagarkatti, Jason L. Kubinak, 2022, Nature Communications

Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome

Benoit Chassaing, Charlene Compher, Brittaney Bonhomme, Qing Liu, Yuan Tian, William Walters, Lisa Nessel, Clara Delaroque, Fuhua Hao, Victoria Gershuni, Lillian Chau, Josephine Ni, Meenakshi Bewtra, Lindsey Albenberg, Alexis Bretin, Liam McKeever, Ruth E. Ley, Andrew D. Patterson, Gary D. Wu, Andrew T. Gewirtz, James D. Lewis, 2022, Gastroenterology on p. 743-756

The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice

Shengzhong Su, Laura J. Billy, Sue Chang, Frank J. Gonzalez, Andrew D. Patterson, Jeffrey M. Peters, 2022, Toxicology

Metabolomic profiling of stool of two-year old children from the INSIGHT study reveals links between butyrate and BMI

D Nandy, Craig SJC, J Cai, Y Tian, I Paul, J Savage, M Marini, E Hohman, M Reimherr, Andrew Patterson, K Makova, F Chiaromonte, 2022, Pediatric obesity on p. e12833

Reconstitution of the host holobiont in germ-free born male rats acutely increases bone growth and affects marrow cellular content

Piotr J. Czernik, Rachel M. Golonka, Saroj Chakraborty, Beng San Yeoh, Ahmed A. Abokor, Piu Saha, Ji Youn Yeo, Blair Mell, Xi Cheng, Sudipta Baroi, Yuan Tian, Andrew D. Patterson, Bina Joe, Matam Vijay-Kumar, Beata Lecka-Czernik, 2021, Physiological Genomics on p. 518-533

Role of bile acids and gut bacteria in healthy ageing of centenarians.

B Rimal, Andrew Patterson, 2021, Nature on p. 380-381

The east asian gut microbiome is distinct from colocalized white subjects and connected to metabolic health

Qi Yan Ang, Diana L. Alba, Vaibhav Upadhyay, Jordan E. Bisanz, Jingwei Cai, Ho Lim Lee, Eliseo Barajas, Grace Wei, Cecilia Noecker, Andrew D. Patterson, Suneil K. Koliwad, Peter J. Turnbaugh, 2021, eLife

Exercise Training Reverses Gut Dysbiosis in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis: A Proof of Concept Study

Alexa Hughes, Jessica Dahmus, Gloriany Rivas, Breianna Hummer, Jeremy R. Chen See, Justin R. Wright, Regina Lamendella, Kathryn H. Schmitz, Christopher Sciamanna, Mack Ruffin, Andrew D. Patterson, Rohit Loomba, Jonathan G. Stine, 2021, Clinical Gastroenterology and Hepatology on p. 1723-1725

Caloric restriction disrupts the microbiota and colonization resistance

Reiner Jumpertz von Schwartzenberg, Jordan E. Bisanz, Svetlana Lyalina, Peter Spanogiannopoulos, Qi Yan Ang, Jingwei Cai, Sophia Dickmann, Marie Friedrich, Su Yang Liu, Stephanie L. Collins, Danielle Ingebrigtsen, Steve Miller, Jessie A. Turnbaugh, Andrew D. Patterson, Katherine S. Pollard, Knut Mai, Joachim Spranger, Peter J. Turnbaugh, 2021, Nature on p. 272-277

Comparison of the effects of short-term feeding of sodium acetate and sodium bicarbonate on milk fat production.

C Matamoros, J Cai, A Patterson, Kevin Harvatine, 2021, Journal of Dairy Science on p. 7572-7582

Most-Cited Papers

Aryl hydrocarbon receptor ligands in cancer: Friend and foe

Iain A. Murray, Andrew D. Patterson, Gary H. Perdew, 2014, Nature Reviews Cancer on p. 801-814

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

Fei Li, Changtao Jiang, Kristopher W. Krausz, Yunfei Li, Istvan Albert, Haiping Hao, Kristin M. Fabre, James B. Mitchell, Andrew D. Patterson, Frank J. Gonzalez, 2013, Nature Communications

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Lulu Sun, Cen Xie, Guang Wang, Yue Wu, Qing Wu, Xuemei Wang, Jia Liu, Yangyang Deng, Jialin Xia, Bo Chen, Songyang Zhang, Chuyu Yun, Guan Lian, Xiujuan Zhang, Heng Zhang, William H. Bisson, Jingmin Shi, Xiaoxia Gao, Pupu Ge, Cuihua Liu, Kristopher W. Krausz, Robert G. Nichols, Jingwei Cai, Bipin Rimal, Andrew D. Patterson, Xian Wang, Frank J. Gonzalez, Changtao Jiang, 2018, Nature Medicine on p. 1919-1929

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu G. Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez, 2015, Nature Communications

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota

Guolin Li, Cen Xie, Siyu Lu, Robert G. Nichols, Yuan Tian, Licen Li, Daxeshkumar Patel, Yinyan Ma, Chad N. Brocker, Tingting Yan, Kristopher W. Krausz, Rong Xiang, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez, 2017, Cell Metabolism on p. 672-685.e4

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

Preeti Pathak, Cen Xie, Robert G. Nichols, Jessica M. Ferrell, Shannon Boehme, Kristopher W. Krausz, Andrew D. Patterson, Frank J. Gonzalez, John Y.L. Chiang, 2018, Hepatology on p. 1574-1588

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

Vishal Singh, Beng San Yeoh, Benoit Chassaing, Xia Xiao, Piu Saha, Rodrigo Aguilera Olvera, John D. Lapek, Limin Zhang, Wei Bei Wang, Sijie Hao, Michael D. Flythe, David J. Gonzalez, Patrice D. Cani, Jose R. Conejo-Garcia, Na Xiong, Mary J. Kennett, Bina Joe, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2018, Cell on p. 679-694.e22

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Health Perspectives on p. 679-688

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific Reports