Andrew Patterson
Professor and Huck Chair of Molecular Toxicology; Faculty Oversight, Metabolomics Core Facility
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322 Huck Life Sciences
University Park, PA - adp117@psu.edu
- 814-867-4565
Research Summary
The Patterson lab is focused on understanding the host-metabolite-microbiome axis
Huck Affiliations
- Metabolomics Core Facility
- Integrative and Biomedical Physiology
- Molecular, Cellular, and Integrative Biosciences
- Bioinformatics and Genomics
- Center for Molecular Toxicology and Carcinogenesis
- Microbiome Center
Links
Publication Tags
Gastrointestinal Microbiome Ligands Obesity Bile Acids And Salts Liver Microbiota Non Alcoholic Fatty Liver Disease Hydrocarbons Mice Intestines Metabolomics Ursodeoxycholic Acid Metformin Aryl Hydrocarbon Receptors Glycine Muricholic Acid Saccharin Homeostasis Tempol Trichlorosucrose Methotrexate Selenium Metabolism Therapeutics SerumMost Recent Papers
The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis
Qing Liu, Limin Zhang, Erik L. Allman, Troy D. Hubbard, Iain A. Murray, Fuhua Hao, Yuan Tian, Wei Gui, Robert G. Nichols, Philip B. Smith, Mallappa Anitha, Gary H. Perdew, Andrew D. Patterson, 2021, Toxicology
The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis
Alejandro Artacho, Sandrine Isaac, Renuka Nayak, Alejandra Flor-Duro, Margaret Alexander, Imhoi Koo, Julia Manasson, Philip B. Smith, Pamela Rosenthal, Yamen Homsi, Percio Gulko, Javier Pons, Leonor Puchades-Carrasco, Peter Izmirly, Andrew Patterson, Steven B. Abramson, Antonio Pineda-Lucena, Peter J. Turnbaugh, Carles Ubeda, Jose U. Scher, 2021, Arthritis and Rheumatology on p. 931-942
Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation
Renuka R. Nayak, Margaret Alexander, Ishani Deshpande, Kye Stapleton-Gray, Bipin Rimal, Andrew D. Patterson, Carles Ubeda, Jose U. Scher, Peter J. Turnbaugh, 2021, Cell Host and Microbe on p. 362-377.e11
Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice
Jenessa A. Winston, Alissa Rivera, Jingwei Cai, Andrew D. Patterson, Casey M. Theriot, 2021, PLoS One
Sample preparation and data analysis for NMR-based metabolomics
Tapas K. Mal, Yuan Tian, Andrew D. Patterson, 2021, on p. 301-313
Impaired intestinal akkermansia muciniphila and aryl hydrocarbon receptor ligands contribute to nonalcoholic fatty liver disease in mice
Zunji Shi, Hehua Lei, Gui Chen, Peihong Yuan, Zheng Cao, Hooi Leng Ser, Xuehang Zhu, Fang Wu, Caixiang Liu, Manyuan Dong, Yuchen Song, Yangyang Guo, Chuan Chen, Kexin Hu, Yifan Zhu, Xin An Zeng, Jinlin Zhou, Yujing Lu, Andrew D. Patterson, Limin Zhang, 2021, mSystems
Selenium-dependent metabolic reprogramming during inflammation and resolution
Arvind M. Korwar, Ayaan Hossain, Tai Jung Lee, Ashley E. Shay, Venkatesha Basrur, Kevin Conlon, Philip B. Smith, Bradley A. Carlson, Howard M. Salis, Andrew D. Patterson, K. Sandeep Prabhu, 2021, Journal of Biological Chemistry
Exercise Training Reverses Gut Dysbiosis in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis
Alexa Hughes, Jessica Dahmus, Gloriany Rivas, Breianna Hummer, Jeremy R. Chen See, Justin R. Wright, Regina Lamendella, Kathryn H. Schmitz, Christopher Sciamanna, Mack Ruffin, Andrew D. Patterson, Rohit Loomba, Jonathan G. Stine, 2021, Clinical Gastroenterology and Hepatology
Quantitative analysis of bile acid with UHPLC-MS/MS
Yuan Tian, Jingwei Cai, Erik L. Allman, Philip B. Smith, Andrew D. Patterson, 2021, on p. 291-300
Comparison of the effects of short-term feeding of sodium acetate and sodium bicarbonate on milk fat production
C. Matamoros, J. Cai, A. D. Patterson, K. J. Harvatine, 2021, Journal of Dairy Science
Most-Cited Papers
Aryl hydrocarbon receptor ligands in cancer
Iain A. Murray, Andrew D. Patterson, Gary H. Perdew, 2014, Nature Reviews Cancer on p. 801-814
Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
Fei Li, Changtao Jiang, Kristopher W. Krausz, Yunfei Li, Istvan Albert, Haiping Hao, Kristin M. Fabre, James B. Mitchell, Andrew D. Patterson, Frank J. Gonzalez, 2013, Nature Communications
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu G. Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez, 2015, Nature Communications
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin
Lulu Sun, Cen Xie, Guang Wang, Yue Wu, Qing Wu, Xuemei Wang, Jia Liu, Yangyang Deng, Jialin Xia, Bo Chen, Songyang Zhang, Chuyu Yun, Guan Lian, Xiujuan Zhang, Heng Zhang, William H. Bisson, Jingmin Shi, Xiaoxia Gao, Pupu Ge, Cuihua Liu, Kristopher W. Krausz, Robert G. Nichols, Jingwei Cai, Bipin Rimal, Andrew D. Patterson, Xian Wang, Frank J. Gonzalez, Changtao Jiang, 2018, Nature Medicine on p. 1919-1929
Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling
Andrew David Patterson, Olivier Maurhofer, Diren Beyoǧlu, Christian Lanz, Kristopher W. Krausz, Thomas Pabst, Frank J. Gonzalez, Jean François Dufour, Jeffrey R. Idle, 2011, Cancer Research on p. 6590-6600
Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation
Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Health Perspectives on p. 679-688
Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota
Guolin Li, Cen Xie, Siyu Lu, Robert G. Nichols, Yuan Tian, Licen Li, Daxeshkumar Patel, Yinyan Ma, Chad N. Brocker, Tingting Yan, Kristopher W. Krausz, Rong Xiang, Oksana Gavrilova, Andrew David Patterson, Frank J. Gonzalez, 2017, Cell Metabolism on p. 672-685.e4
Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis
Naoki Tanaka, Tsutomu Matsubara, Kristopher W. Krausz, Andrew D. Patterson, Frank J. Gonzalez, 2012, Hepatology on p. 118-129
Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles
Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific Reports
News Articles Featuring Andrew Patterson
Feb 09, 2021
Andrew Patterson receives Society of Toxicology Achievement Award
The Society of Toxicology has named Tombros Early Career Professor Andrew Patterson of Penn State as the recipient of its 2021 Achievement Award, recognizing his significant contributions to the field of toxicology within 15 years of obtaining the highest earned degree.
Full Article
Mar 11, 2020
Listening to your gut: A powerful new tool on the microbiome and cell metabolism
Many aspects of our lives — not only the presence or absence of certain diseases, but conditions like obesity, sleep patterns, even mood — may be determined, to a surprising extent, by the microbes living inside of us.
Full Article
Jan 21, 2020
Persistent environmental contaminant changes the gut microbiome of mice
An industrial chemical — phased out since 2002, but previously used in stain and water-repellent products and firefighting foam — alters the gut microbiome of mice and could have implications for human health, according to an international team of researchers.
Full Article