Jack Vanden Heuvel

Director of the Center for Excellence in Nutrigenomics; Professor of Molecular Toxicology

Jack Vanden Heuvel

Research Summary

Mechanisms of action of hypolipidemic drugs and peroxisome proliferators; steroid hormone receptor-mediated signal transduction; signal transduction by lipids and fatty acids; receptor-mediated carcinogenesis.

Huck Affiliations

Links

Publication Tags

Macrophages Peroxisome Proliferator Activated Receptors Liver Wastewater Cytoplasmic And Nuclear Receptors Cells Xenobiotics Ppar Alpha Glycogen Synthase Kinase 3 Rodentia Glycogen Synthase Kinases Phosphorylation Serine Biliverdin Reductase Cholesterol Triclosan Prostaglandins Pharmaceutical Preparations Gene Expression Stearoyl Coa Desaturase Alpha Linolenic Acid Unsaturated Fatty Acids Oils Neoplasms Genes

Most Recent Papers

Detection and removal of biologically active organic micropollutants from hospital wastewater

Luis Castillo Meza, Paulina Piotrowski, James Farnan, Travis L. Tasker, Boya Xiong, Benedikt Weggler, Kyra Murrell, Frank L. Dorman, John P. Vanden Heuvel, William D. Burgos, 2020, Science of the Total Environment

Environmental and Human Health Impacts of Spreading Oil and Gas Wastewater on Roads

T. L. Tasker, W. D. Burgos, P. Piotrowski, L. Castillo-Meza, T. A. Blewett, K. B. Ganow, A. Stallworth, P. L.M. Delompré, G. G. Goss, L. B. Fowler, J. P. Vanden Heuvel, F. Dorman, N. R. Warner, 2018, Environmental Science and Technology on p. 7081-7091

Diets low in saturated fat with different unsaturated fatty acid profiles similarly increase serum-mediated cholesterol efflux from THP-1 macrophages in a population with or at risk for metabolic syndrome

Xiaoran Liu, Josephine Garban, Peter J. Jones, John Patrick Vanden Heuvel, Benoît Lamarche, David J. Jenkins, Philip W. Connelly, Patrick Couture, Shuaihua Pu, Jennifer Anne Fleming, Sheila Grace West, Penny Margaret Kris-Etherton, 2018, Journal of Nutrition on p. 721-728

Replication study

John P. Vanden Heuvel, Ewa Maddox, Samar W. Maalouf, Elizabeth Iorns, Rachel Tsui, Alexandria Denis, Nicole Perfito, Timothy M. Errington, 2018, eLife

Effects of cranberry extracts on gene expression in THP-1 cells

Daniel B. Hannon, Jerry T. Thompson, Christina Khoo, Vijaya Juturu, John P. Vanden Heuvel, 2017, Food Science and Nutrition on p. 148-159

Therapeutic potential of GW501516 and the role of Peroxisome proliferator-activated receptor β/δ and B-cell lymphoma 6 in inflammatory signaling in human pancreatic cancer cells

Russell W. Smith, Jeffrey D. Coleman, Jerry T. Thompson, John Patrick Vanden Heuvel, 2016, Biochemistry and Biophysics Reports on p. 395-402

Biliverdin reductase A attenuates hepatic steatosis by inhibition of Glycogen Synthase Kinase (GSK) 3β phosphorylation of serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α

Terry D. Hinds, Katherine A. Burns, Peter A. Hosick, Lucien McBeth, Andrea Nestor-Kalinoski, Heather A. Drummond, Abdulhadi A. Alamodi, Michael W. Hankins, John P. Vanden Heuvel, David E. Stec, 2016, Journal of Biological Chemistry on p. 25179-25191

Registered report

John P. Vanden Heuvel, Jessica Bullenkamp, Elizabeth Iorns, William Gunn, Fraser Tan, Joelle Lomax, Nicole Perfito, Timothy Errington, 2016, eLife

Effects of whole and refined grains in a weight-loss diet on markers of metabolic syndrome in individuals with increased waist circumference

Kristina Harris Jackson, Sheila G. West, John P. Vanden Heuvel, Satya S. Jonnalagadda, Alastair B. Ross, Alison M. Hill, Jessica A. Grieger, Susan K. Lemieux, Penny M. Kris-Etherton, 2014, American Journal of Clinical Nutrition on p. 577-586

Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors

Katie B. Paul, Jerry T. Thompson, Steven O. Simmons, John Patrick Vanden Heuvel, Kevin M. Crofton, 2013, Toxicology in Vitro on p. 2049-2060

Most-Cited Papers

Δ <sup>12</sup>-prostaglandin J <sub>3</sub>, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice

Shailaja Hegde, Naveen Kaushal, Kodihalli C. Ravindra, Christopher Chiaro, Kelsey T. Hafer, Ujjawal H. Gandhi, Jerry T. Thompson, John Patrick Vanden Heuvel, Mary J. Kennett, Pamela Hankey Giblin, Robert Paulson, Kumble Sandeep Prabhu, 2011, Blood on p. 6909-6919

Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors

Katie B. Paul, Jerry T. Thompson, Steven O. Simmons, John Patrick Vanden Heuvel, Kevin M. Crofton, 2013, Toxicology in Vitro on p. 2049-2060

Effects of whole and refined grains in a weight-loss diet on markers of metabolic syndrome in individuals with increased waist circumference

Kristina Harris Jackson, Sheila G. West, John P. Vanden Heuvel, Satya S. Jonnalagadda, Alastair B. Ross, Alison M. Hill, Jessica A. Grieger, Susan K. Lemieux, Penny M. Kris-Etherton, 2014, American Journal of Clinical Nutrition on p. 577-586

Biliverdin reductase A attenuates hepatic steatosis by inhibition of Glycogen Synthase Kinase (GSK) 3β phosphorylation of serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α

Terry D. Hinds, Katherine A. Burns, Peter A. Hosick, Lucien McBeth, Andrea Nestor-Kalinoski, Heather A. Drummond, Abdulhadi A. Alamodi, Michael W. Hankins, John P. Vanden Heuvel, David E. Stec, 2016, Journal of Biological Chemistry on p. 25179-25191

Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression

Jun Zhang, Penny M. Kris-Etherton, Jerry T. Thompson, Daniel B. Hannon, Peter J. Gillies, John P. Vanden Heuvel, 2012, Journal of Nutritional Biochemistry on p. 400-409

Nutrigenomics and nutrigenetics of ω3 polyunsaturated fatty acids

John P. Vanden Heuvel, 2012, Progress in Molecular Biology and Translational Science on p. 75-112

15-deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub>-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor γ

Priyadarshini Raman, Barbara L.F. Kaplan, Jerry T. Thompson, John P. Vanden Heuvel, Norbert E. Kaminski, 2011, Molecular pharmacology on p. 201-209

Mechanistic examination of walnuts in prevention of breast cancer

John P.Vanden Heuvel, Benjamin J. Belda, Dan B. Hannon, Penny M. Kris-Etherton, Jessica A. Grieger, Jun Zhang, Jerry T. Thompson, 2012, Nutrition and cancer on p. 1078-1086

Walnut oil increases cholesterol efflux through inhibition of stearoyl CoA desaturase 1 in THP-1 macrophage-derived foam cells

Jun Zhang, Jessica A. Grieger, Penny Margaret Kris-Etherton, Jerry T. Thompson, Peter J. Gillies, Jennifer Anne Fleming, John Patrick Vanden Heuvel, 2011, Nutrition and Metabolism

Inhibition of macrophage adhesion activity by 9trans,11trans-conjugated linoleic acid

Yunkyoung Lee, John Patrick Vanden Heuvel, 2010, Journal of Nutritional Biochemistry on p. 490-497