Jack Vanden Heuvel
Director of the Center for Excellence in Nutrigenomics; Professor of Molecular Toxicology
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204 Huck Life Sciences
University Park, PA - jpv2@psu.edu
- 814-863-8532
Research Summary
Mechanisms of action of hypolipidemic drugs and peroxisome proliferators; steroid hormone receptor-mediated signal transduction; signal transduction by lipids and fatty acids; receptor-mediated carcinogenesis.
Huck Affiliations
Links
Most Recent Publications
Geospatial and socioeconomic factors of PFAS contamination in private drinking water wells: Insights for monitoring and management
Kelly Kosiarski, Tamie L. Veith, Faith A. Kibuye, Jennifer Fetter, Susan Boser, John P. Vanden Heuvel, Cheryl L. Thompson, Heather E. Preisendanz, 2025, Journal of Environmental Management
Bile salt hydrolase catalyses formation of amine-conjugated bile acids
J Bisanz, Bipin Rimal, Stephanie Collins, Emily Weinert, Ceylan Tanes, A Patterson, Megan Granda, Imhoi Koo, E Rocha, Sumeet Solanka, M Granda, Nushrat Hoque, Sumeet Solanki, Nushrat Hoque, Emily Gentry, Emily Gentry, Tingting Yan, Imhoi Koo, Erin Reilly, Kristopher Krausz, Dhimant Desai, Fuhua Hao, Shantu Amin, Devendra Paudel, Edson Rocha, Vishal Singh, James Coleman, Tingting Yan, Yatrik Shah, Min Kim, Kyle Bittinger, Frank Gonzalez, John Vanden Heuvel, Joseph Zackular, Kristopher Krausz, A Patterson, Dhimant Desai, Shantu Amin, James Coleman, Yatrik Shah, Jordan Bisanz, Frank Gonzalez, John Heuvel, John P. Vanden Heuvel, Gary Wu, Babette Zemel, Pieter Dorrestein, Andrew Patterson, 2024, Nature on p. 859-868
Priority screening of contaminants of emerging concern (CECs) in surface water: Comparing cell-based bioassays and exposure-activity ratios (EARs)
John P. Vanden Heuvel, Megan Granda, Francesca Ferguson, Scott R. Glaberman, Heather E. Preisendanz, 2024, Science of the Total Environment on p. 176115
Toxicity and chemical composition of commercial road palliatives versus oil and gas produced waters
James Farnan, John P. Vanden Heuvel, Frank L. Dorman, Nathaniel R. Warner, William D. Burgos, 2023, Environmental Pollution
Preclinical Demonstration of a Novel Treatment with High Efficacy and No Detectable Toxicity for Inflammatory Skin Conditions including Psoriasis
John P. Vanden Heuvel, Shuling Zhou, Anisha B. Patel, Harry N. Kamerow, Peter Baran, John P. Ford, 2023, BioMed Research International
Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer
Kun Ming Chen, Henry Thompson, John P. Vanden-Heuvel, Yuan Wan Sun, Neil Trushin, Cesar Aliaga, Krishne Gowda, Shantu Amin, Bruce Stanley, Andrea Manni, Karam El-Bayoumy, 2021, Scientific Reports
Accumulating evidence to support the safe and efficacious use of a proprietary blend of capsaicinoids in mediating risk factors for obesity
Javahar Kohli Mariwala, Deshanie Rai, Muralidhara Padigaru, Abhijeet Ashok Morde, Ewa Maddox, Samar Maalouf, Kayla Smith, John P. Vanden Heuvel, 2021, Food Science and Nutrition on p. 2823-2835
Detection and removal of biologically active organic micropollutants from hospital wastewater
Luis Castillo Meza, Paulina Piotrowski, James Farnan, Travis Tasker, Boya Xiong, Benedikt Weggler, Kyra Murrell, Franklin Lewis Dorman, Jr., F Dorman, John P. Vanden Heuvel, William Burgos, 2020, Science of the Total Environment on p. 134469 (8)
Environmental and Human Health Impacts of Spreading Oil and Gas Wastewater on Roads
T. L. Tasker, W. D. Burgos, P. Piotrowski, L. Castillo-Meza, T. A. Blewett, K. B. Ganow, A. Stallworth, P. L.M. Delompré, G. G. Goss, L. B. Fowler, J. P. Vanden Heuvel, F. Dorman, N. R. Warner, 2018, Environmental Science & Technology on p. 7081-7091
Diets low in saturated fat with different unsaturated fatty acid profiles similarly increase serum-mediated cholesterol efflux from THP-1 macrophages in a population with or at risk for metabolic syndrome: The Canola Oil Multicenter Intervention Trial
Xiaoran Liu, Josephine Garban, Peter J. Jones, Jack Vanden Heuvel, Benoît Lamarche, David J. Jenkins, Philip W. Connelly, Patrick Couture, Shuaihua Pu, Jennifer A. Fleming, Sheila G. West, Penny M. Kris-Etherton, 2018, Journal of Nutrition on p. 721-728
Most-Cited Papers
Biliverdin reductase A attenuates hepatic steatosis by inhibition of Glycogen Synthase Kinase (GSK) 3β phosphorylation of serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α
Terry D. Hinds, Katherine A. Burns, Peter A. Hosick, Lucien McBeth, Andrea Nestor-Kalinoski, Heather A. Drummond, Abdulhadi A. Alamodi, Michael W. Hankins, John P. Vanden Heuvel, David E. Stec, 2016, Journal of Biological Chemistry on p. 25179-25191
Bile salt hydrolase catalyses formation of amine-conjugated bile acids
J Bisanz, Bipin Rimal, Stephanie Collins, Emily Weinert, Ceylan Tanes, A Patterson, Megan Granda, Imhoi Koo, E Rocha, Sumeet Solanka, M Granda, Nushrat Hoque, Sumeet Solanki, Nushrat Hoque, Emily Gentry, Emily Gentry, Tingting Yan, Imhoi Koo, Erin Reilly, Kristopher Krausz, Dhimant Desai, Fuhua Hao, Shantu Amin, Devendra Paudel, Edson Rocha, Vishal Singh, James Coleman, Tingting Yan, Yatrik Shah, Min Kim, Kyle Bittinger, Frank Gonzalez, John Vanden Heuvel, Joseph Zackular, Kristopher Krausz, A Patterson, Dhimant Desai, Shantu Amin, James Coleman, Yatrik Shah, Jordan Bisanz, Frank Gonzalez, John Heuvel, John P. Vanden Heuvel, Gary Wu, Babette Zemel, Pieter Dorrestein, Andrew Patterson, 2024, Nature on p. 859-868
Environmental and Human Health Impacts of Spreading Oil and Gas Wastewater on Roads
T. L. Tasker, W. D. Burgos, P. Piotrowski, L. Castillo-Meza, T. A. Blewett, K. B. Ganow, A. Stallworth, P. L.M. Delompré, G. G. Goss, L. B. Fowler, J. P. Vanden Heuvel, F. Dorman, N. R. Warner, 2018, Environmental Science & Technology on p. 7081-7091
Detection and removal of biologically active organic micropollutants from hospital wastewater
Luis Castillo Meza, Paulina Piotrowski, James Farnan, Travis Tasker, Boya Xiong, Benedikt Weggler, Kyra Murrell, Franklin Lewis Dorman, Jr., F Dorman, John P. Vanden Heuvel, William Burgos, 2020, Science of the Total Environment on p. 134469 (8)
Replication study: Systematic identification of genomic markers of drug sensitivity in cancer cells
John P. Vanden Heuvel, Ewa Maddox, Samar W. Maalouf, Elizabeth Iorns, Rachel Tsui, Alexandria Denis, Nicole Perfito, Timothy M. Errington, 2018, eLife
Diets low in saturated fat with different unsaturated fatty acid profiles similarly increase serum-mediated cholesterol efflux from THP-1 macrophages in a population with or at risk for metabolic syndrome: The Canola Oil Multicenter Intervention Trial
Xiaoran Liu, Josephine Garban, Peter J. Jones, Jack Vanden Heuvel, Benoît Lamarche, David J. Jenkins, Philip W. Connelly, Patrick Couture, Shuaihua Pu, Jennifer A. Fleming, Sheila G. West, Penny M. Kris-Etherton, 2018, Journal of Nutrition on p. 721-728
Effects of cranberry extracts on gene expression in THP-1 cells
Daniel B. Hannon, Jerry T. Thompson, Christina Khoo, Vijaya Juturu, John P. Vanden Heuvel, 2017, Food Science and Nutrition on p. 148-159
Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer
Kun Ming Chen, Henry Thompson, John P. Vanden-Heuvel, Yuan Wan Sun, Neil Trushin, Cesar Aliaga, Krishne Gowda, Shantu Amin, Bruce Stanley, Andrea Manni, Karam El-Bayoumy, 2021, Scientific Reports
Accumulating evidence to support the safe and efficacious use of a proprietary blend of capsaicinoids in mediating risk factors for obesity
Javahar Kohli Mariwala, Deshanie Rai, Muralidhara Padigaru, Abhijeet Ashok Morde, Ewa Maddox, Samar Maalouf, Kayla Smith, John P. Vanden Heuvel, 2021, Food Science and Nutrition on p. 2823-2835
Registered report: Systematic identification of genomic markers of drug sensitivity in cancer cells
John P. Vanden Heuvel, Jessica Bullenkamp, Elizabeth Iorns, William Gunn, Fraser Tan, Joelle Lomax, Nicole Perfito, Timothy Errington, 2016, eLife
News Articles Featuring Jack Vanden Heuvel
Jun 16, 2025
‘Forever chemicals’ detected in 65% of sampled private wells in Pennsylvania
Researchers find 18% of sampled wells have PFAS levels beyond drinking water standards; compounds detected most often, and in the highest concentrations, in wells in the southeastern part of the state.
Full Article
Mar 11, 2025
Abortion restriction based on environmental impacts fails in Montana
A Montana bill to restrict abortion medicine based on effects on the environment fails on a tied vote in 2025.
Full Article
Jan 30, 2025
‘Using the devil’s own tools against them': Abortion opponents turn to environmental laws
Several states are trying to curtail abortion medication by claiming mifepristone could contaminate drinking water.
Full Article
Nov 22, 2024
Alternate stream water-testing method detects emerging contaminants
In a study on central Pennsylvania streams, a new way of analyzing water quality reveals chemicals from pesticides, pharmaceuticals and personal care products.
Full Article
Feb 28, 2024
New role for bacterial enzyme in gut metabolism revealed
Bile acids long have been known to play a role in human metabolism. Synthesized from cholesterol in the liver, bile acids are involved in digestive processes, particularly in absorbing fat.
Full Article
Mar 31, 2023
The EPA doesn’t require safety tests for most chemicals, including the three that spilled into a Delaware River tributary
The EPA doesn’t require safety tests for most chemicals, including the three that spilled into a Delaware River tributary
Full Article