Jack Vanden Heuvel

Director of the Center for Excellence in Nutrigenomics; Professor of Molecular Toxicology

Jack Vanden Heuvel

Research Summary

Mechanisms of action of hypolipidemic drugs and peroxisome proliferators; steroid hormone receptor-mediated signal transduction; signal transduction by lipids and fatty acids; receptor-mediated carcinogenesis.

Huck Affiliations

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Wastewater Cells Gene Expression Peroxisome Proliferator Activated Receptors Health Diet Genes Metabolic Syndrome Oils Liver Macrophages Fats Cytoplasmic And Nuclear Receptors Neoplasms Gw 501516 Drug Human Health Xenobiotics Micropollutant Serum Extracts Therapeutics Obesity Hospital Gas

Most Recent Publications

Toxicity and chemical composition of commercial road palliatives versus oil and gas produced waters

James Farnan, John P. Vanden Heuvel, Frank L. Dorman, Nathaniel R. Warner, William D. Burgos, 2023, Environmental Pollution

Preclinical Demonstration of a Novel Treatment with High Efficacy and No Detectable Toxicity for Inflammatory Skin Conditions including Psoriasis

John P. Vanden Heuvel, Shuling Zhou, Anisha B. Patel, Harry N. Kamerow, Peter Baran, John P. Ford, 2023, BioMed Research International

Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer

Kun Ming Chen, Henry Thompson, John P. Vanden-Heuvel, Yuan Wan Sun, Neil Trushin, Cesar Aliaga, Krishne Gowda, Shantu Amin, Bruce Stanley, Andrea Manni, Karam El-Bayoumy, 2021, Scientific Reports

Accumulating evidence to support the safe and efficacious use of a proprietary blend of capsaicinoids in mediating risk factors for obesity

Javahar Kohli Mariwala, Deshanie Rai, Muralidhara Padigaru, Abhijeet Ashok Morde, Ewa Maddox, Samar Maalouf, Kayla Smith, John P. Vanden Heuvel, 2021, Food Science and Nutrition on p. 2823-2835

Detection and removal of biologically active organic micropollutants from hospital wastewater

Luis Castillo Meza, Paulina Piotrowski, James Farnan, Travis Tasker, Boya Xiong, Benedikt Weggler, Kyra Murrell, Franklin Lewis Dorman, Jr., F Dorman, John P. Vanden Heuvel, William Burgos, 2020, Science of the Total Environment on p. 134469 (8)

Environmental and Human Health Impacts of Spreading Oil and Gas Wastewater on Roads

T. L. Tasker, W. D. Burgos, P. Piotrowski, L. Castillo-Meza, T. A. Blewett, K. B. Ganow, A. Stallworth, P. L.M. Delompré, G. G. Goss, L. B. Fowler, J. P. Vanden Heuvel, F. Dorman, N. R. Warner, 2018, Environmental Science & Technology on p. 7081-7091

Diets low in saturated fat with different unsaturated fatty acid profiles similarly increase serum-mediated cholesterol efflux from THP-1 macrophages in a population with or at risk for metabolic syndrome: The Canola Oil Multicenter Intervention Trial

Xiaoran Liu, Josephine Garban, Peter J. Jones, Jack Vanden Heuvel, Benoît Lamarche, David J. Jenkins, Philip W. Connelly, Patrick Couture, Shuaihua Pu, Jennifer A. Fleming, Sheila G. West, Penny M. Kris-Etherton, 2018, Journal of Nutrition on p. 721-728

Replication study: Systematic identification of genomic markers of drug sensitivity in cancer cells

John P. Vanden Heuvel, Ewa Maddox, Samar W. Maalouf, Elizabeth Iorns, Rachel Tsui, Alexandria Denis, Nicole Perfito, Timothy M. Errington, 2018, eLife

Effects of cranberry extracts on gene expression in THP-1 cells

Daniel B. Hannon, Jerry T. Thompson, Christina Khoo, Vijaya Juturu, John P. Vanden Heuvel, 2017, Food Science and Nutrition on p. 148-159

Therapeutic potential of GW501516 and the role of Peroxisome proliferator-activated receptor β/δ and B-cell lymphoma 6 in inflammatory signaling in human pancreatic cancer cells

Russell W. Smith, Jeffrey D. Coleman, Jerry T. Thompson, John P. Vanden Heuvel, 2016, Biochemistry and Biophysics Reports on p. 395-402

Most-Cited Papers

Biliverdin reductase A attenuates hepatic steatosis by inhibition of Glycogen Synthase Kinase (GSK) 3β phosphorylation of serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α

Terry D. Hinds, Katherine A. Burns, Peter A. Hosick, Lucien McBeth, Andrea Nestor-Kalinoski, Heather A. Drummond, Abdulhadi A. Alamodi, Michael W. Hankins, John P. Vanden Heuvel, David E. Stec, 2016, Journal of Biological Chemistry on p. 25179-25191

Effects of whole and refined grains in a weight-loss diet on markers of metabolic syndrome in individuals with increased waist circumference: A randomized controlled-feeding trial

Kristina Harris Jackson, Sheila G. West, John P. Vanden Heuvel, Satya S. Jonnalagadda, Alastair B. Ross, Alison M. Hill, Jessica A. Grieger, Susan K. Lemieux, Penny M. Kris-Etherton, 2014, American Journal of Clinical Nutrition on p. 577-586

Environmental and Human Health Impacts of Spreading Oil and Gas Wastewater on Roads

T. L. Tasker, W. D. Burgos, P. Piotrowski, L. Castillo-Meza, T. A. Blewett, K. B. Ganow, A. Stallworth, P. L.M. Delompré, G. G. Goss, L. B. Fowler, J. P. Vanden Heuvel, F. Dorman, N. R. Warner, 2018, Environmental Science & Technology on p. 7081-7091

Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors

Katie B. Paul, Jerry T. Thompson, Steven O. Simmons, John P. Vanden Heuvel, Kevin M. Crofton, 2013, Toxicology in Vitro on p. 2049-2060

Effects of a DASH-like diet containing lean beef on vascular health

M. A. Roussell, A. M. Hill, T. L. Gaugler, S. G. West, J. S. Ulbrecht, J. P. Vanden Heuvel, P. J. Gillies, P. M. Kris-Etherton, 2014, Journal of Human Hypertension on p. 600-605

Detection and removal of biologically active organic micropollutants from hospital wastewater

Luis Castillo Meza, Paulina Piotrowski, James Farnan, Travis Tasker, Boya Xiong, Benedikt Weggler, Kyra Murrell, Franklin Lewis Dorman, Jr., F Dorman, John P. Vanden Heuvel, William Burgos, 2020, Science of the Total Environment on p. 134469 (8)

Role of peroxisome proliferator-activated receptor β/δ and B-cell lymphoma-6 in regulation of genes involved in metastasis and migration in pancreatic cancer cells

Jeffrey D. Coleman, Jerry T. Thompson, Russell W. Smith, Bogdan Prokopczyk, John P. Vanden Heuvel, 2013, PPAR Research

Replication study: Systematic identification of genomic markers of drug sensitivity in cancer cells

John P. Vanden Heuvel, Ewa Maddox, Samar W. Maalouf, Elizabeth Iorns, Rachel Tsui, Alexandria Denis, Nicole Perfito, Timothy M. Errington, 2018, eLife

Effects of cranberry extracts on gene expression in THP-1 cells

Daniel B. Hannon, Jerry T. Thompson, Christina Khoo, Vijaya Juturu, John P. Vanden Heuvel, 2017, Food Science and Nutrition on p. 148-159

Diets low in saturated fat with different unsaturated fatty acid profiles similarly increase serum-mediated cholesterol efflux from THP-1 macrophages in a population with or at risk for metabolic syndrome: The Canola Oil Multicenter Intervention Trial

Xiaoran Liu, Josephine Garban, Peter J. Jones, Jack Vanden Heuvel, Benoît Lamarche, David J. Jenkins, Philip W. Connelly, Patrick Couture, Shuaihua Pu, Jennifer A. Fleming, Sheila G. West, Penny M. Kris-Etherton, 2018, Journal of Nutrition on p. 721-728