Jack Vanden Heuvel
Director of the Center for Excellence in Nutrigenomics; Professor of Molecular Toxicology
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204 Huck Life Sciences
University Park, PA - jpv2@psu.edu
- 814-863-8532
Research Summary
Mechanisms of action of hypolipidemic drugs and peroxisome proliferators; steroid hormone receptor-mediated signal transduction; signal transduction by lipids and fatty acids; receptor-mediated carcinogenesis.
Huck Affiliations
Links
Publication Tags
Peroxisome Proliferator Activated Receptors Wastewater Liver Cells Cholesterol Glycogen Synthase Kinase 3 Glycogen Synthase Kinases Phosphorylation Serine Biliverdin Reductase Ppar Alpha Macrophages Diet Pharmaceutical Preparations Omega 3 Fatty Acids Prostaglandins Proteins Gene Expression Cytoplasmic And Nuclear Receptors Health Neoplasms Xenobiotics Therapeutics Stem Cells Gw 501516Most Recent Papers
Detection and removal of biologically active organic micropollutants from hospital wastewater
Luis Castillo Meza, Paulina Piotrowski, James Farnan, Travis L. Tasker, Boya Xiong, Benedikt Weggler, Kyra Murrell, Frank L. Dorman, John P. Vanden Heuvel, William D. Burgos, 2020, Science of the Total Environment
Environmental and Human Health Impacts of Spreading Oil and Gas Wastewater on Roads
T. L. Tasker, W. D. Burgos, P. Piotrowski, L. Castillo-Meza, T. A. Blewett, K. B. Ganow, A. Stallworth, P. L.M. Delompré, G. G. Goss, L. B. Fowler, J. P. Vanden Heuvel, F. Dorman, N. R. Warner, 2018, Environmental Science & Technology on p. 7081-7091
Diets low in saturated fat with different unsaturated fatty acid profiles similarly increase serum-mediated cholesterol efflux from THP-1 macrophages in a population with or at risk for metabolic syndrome: the canola oil multicenter intervention trial
Xiaoran Liu, Josephine Garban, Peter J. Jones, John Patrick Vanden Heuvel, Benoît Lamarche, David J. Jenkins, Philip W. Connelly, Patrick Couture, Shuaihua Pu, Jennifer Anne Fleming, Sheila Grace West, Penny Margaret Kris-Etherton, 2018, Journal of Nutrition on p. 721-728
Replication study: Systematic identification of genomic markers of drug sensitivity in cancer cells
John P. Vanden Heuvel, Ewa Maddox, Samar W. Maalouf, Elizabeth Iorns, Rachel Tsui, Alexandria Denis, Nicole Perfito, Timothy M. Errington, 2018, eLife
Effects of cranberry extracts on gene expression in THP-1 cells
Daniel B. Hannon, Jerry T. Thompson, Christina Khoo, Vijaya Juturu, John P. Vanden Heuvel, 2017, Food Science and Nutrition on p. 148-159
Therapeutic potential of GW501516 and the role of Peroxisome proliferator-activated receptor β/δ and B-cell lymphoma 6 in inflammatory signaling in human pancreatic cancer cells
Russell W. Smith, Jeffrey D. Coleman, Jerry T. Thompson, John P. Vanden Heuvel, 2016, Biochemistry and Biophysics Reports on p. 395-402
Biliverdin reductase A attenuates hepatic steatosis by inhibition of Glycogen Synthase Kinase (GSK) 3β phosphorylation of serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α
Terry D. Hinds, Katherine A. Burns, Peter A. Hosick, Lucien McBeth, Andrea Nestor-Kalinoski, Heather A. Drummond, Abdulhadi A. Alamodi, Michael W. Hankins, John P. Vanden Heuvel, David E. Stec, 2016, Journal of Biological Chemistry on p. 25179-25191
Registered report
John P. Vanden Heuvel, Jessica Bullenkamp, Elizabeth Iorns, William Gunn, Fraser Tan, Joelle Lomax, Nicole Perfito, Timothy Errington, 2016, eLife
Effects of cranberry extracts on gene expression in THP-1 cells.
D Hannon, J Thompson, C Khoo, V Juturu, John Vanden Heuvel, 2016, Food science & nutrition on p. 148-159
Differential nucleobase protection against 5-fluorouracil toxicity for squamous and columnar cells: Implication for tissue function and oncogenesis
John Patrick Vanden Heuvel, Jerry T. Thompson, Prajakta Albrecht, Donald Mandetta, Harry Kamerow, John P. Ford, 2015, Investigational New Drugs on p. 1003-1011
Most-Cited Papers
Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia.
Ann Skulas-Ray, Penny Kris-Etherton, W Harris, John Vanden Heuvel, P Wagner, Sheila West, 2011, American Journal of Clinical Nutrition on p. 243-52
Beef in an optimal lean diet study: Effects on lipids, lipoproteins, and apolipoproteins
Michael A. Roussell, Alison M. Hill, Trent L. Gaugler, Sheila G. West, John P. Vanden Heuvel, Petar Alaupovic, Peter J. Gillies, Penny M. Kris-Etherton, 2012, American Journal of Clinical Nutrition on p. 9-16
Δ <sup>12</sup>-prostaglandin J <sub>3</sub>, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice
Shailaja Hegde, Naveen Kaushal, Kodihalli C. Ravindra, Christopher Chiaro, Kelsey T. Hafer, Ujjawal H. Gandhi, Jerry T. Thompson, John Patrick Vanden Heuvel, Mary J. Kennett, Pamela Hankey Giblin, Robert Paulson, Kumble Sandeep Prabhu, 2011, Blood on p. 6909-6919
Biliverdin reductase A attenuates hepatic steatosis by inhibition of Glycogen Synthase Kinase (GSK) 3β phosphorylation of serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α
Terry D. Hinds, Katherine A. Burns, Peter A. Hosick, Lucien McBeth, Andrea Nestor-Kalinoski, Heather A. Drummond, Abdulhadi A. Alamodi, Michael W. Hankins, John P. Vanden Heuvel, David E. Stec, 2016, Journal of Biological Chemistry on p. 25179-25191
Effects of whole and refined grains in a weight-loss diet on markers of metabolic syndrome in individuals with increased waist circumference: A randomized controlled-feeding trial
Kristina Harris Jackson, Sheila G. West, John P. Vanden Heuvel, Satya S. Jonnalagadda, Alastair B. Ross, Alison M. Hill, Jessica A. Grieger, Susan K. Lemieux, Penny M. Kris-Etherton, 2014, American Journal of Clinical Nutrition on p. 577-586
Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors
Katie B. Paul, Jerry T. Thompson, Steven O. Simmons, John Patrick Vanden Heuvel, Kevin M. Crofton, 2013, Toxicology in Vitro on p. 2049-2060
Development of a cell-based, high-throughput screening assay for cholesterol efflux using a fluorescent mimic of cholesterol
Jun Zhang, Sutang Cai, Blake R. Peterson, Penny Margaret Kris-Etherton, John Patrick Vanden Heuvel, 2011, Assay and Drug Development Technologies on p. 136-146
Effects of a DASH-like diet containing lean beef on vascular health
M. A. Roussell, A. M. Hill, T. L. Gaugler, Sheila Grace West, Jan Ulbrecht, John Patrick Vanden Heuvel, P. J. Gillies, Penny Margaret Kris-Etherton, 2014, Journal of Human Hypertension on p. 600-605
Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action
Jun Zhang, Penny M. Kris-Etherton, Jerry T. Thompson, Daniel B. Hannon, Peter J. Gillies, John P. Vanden Heuvel, 2012, Journal of Nutritional Biochemistry on p. 400-409
15-deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub>-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor γ
Priyadarshini Raman, Barbara L.F. Kaplan, Jerry T. Thompson, John P. Vanden Heuvel, Norbert E. Kaminski, 2011, Molecular Pharmacology on p. 201-209