Jack Vanden Heuvel

Director of the Center for Excellence in Nutrigenomics; Professor of Molecular Toxicology

Jack Vanden Heuvel

Research Summary

Mechanisms of action of hypolipidemic drugs and peroxisome proliferators; steroid hormone receptor-mediated signal transduction; signal transduction by lipids and fatty acids; receptor-mediated carcinogenesis.

Huck Affiliations

Links

Publication Tags

Peroxisome Proliferator Activated Receptors Wastewater Liver Oils Genes Gene Expression Cells Ppar Alpha Glycogen Synthase Kinase 3 Phosphorylation Biliverdin Reductase Glycogen Synthase Kinases Serine Diet Macrophages Health Stearoyl Coa Desaturase Cytoplasmic And Nuclear Receptors Cholesterol Pharmaceutical Preparations Proteins Alpha Linolenic Acid Lipid Metabolism Neoplasms Unsaturated Fatty Acids

Most Recent Papers

Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer

Kun Ming Chen, Henry Thompson, John P. Vanden-Heuvel, Yuan Wan Sun, Neil Trushin, Cesar Aliaga, Krishne Gowda, Shantu Amin, Bruce Stanley, Andrea Manni, Karam El-Bayoumy, 2021, Scientific Reports

Accumulating evidence to support the safe and efficacious use of a proprietary blend of capsaicinoids in mediating risk factors for obesity

Javahar Kohli Mariwala, Deshanie Rai, Muralidhara Padigaru, Abhijeet Ashok Morde, Ewa Maddox, Samar Maalouf, Kayla Smith, John P. Vanden Heuvel, 2021, Food Science and Nutrition on p. 2823-2835

Detection and removal of biologically active organic micropollutants from hospital wastewater

Luis Castillo Meza, Paulina Piotrowski, James Farnan, Travis L. Tasker, Boya Xiong, Benedikt Weggler, Kyra Murrell, Franklin Lewis Dorman, Jr., John P. Vanden Heuvel, William D. Burgos, 2020, Science of the Total Environment

Environmental and Human Health Impacts of Spreading Oil and Gas Wastewater on Roads

T. L. Tasker, W. D. Burgos, P. Piotrowski, L. Castillo-Meza, T. A. Blewett, K. B. Ganow, A. Stallworth, P. L.M. Delompré, G. G. Goss, L. B. Fowler, J. P. Vanden Heuvel, F. Dorman, N. R. Warner, 2018, Environmental Science & Technology on p. 7081-7091

Diets low in saturated fat with different unsaturated fatty acid profiles similarly increase serum-mediated cholesterol efflux from THP-1 macrophages in a population with or at risk for metabolic syndrome: the canola oil multicenter intervention trial

Xiaoran Liu, Josephine Garban, Peter J. Jones, Jack Vanden Heuvel, Benoît Lamarche, David J. Jenkins, Philip W. Connelly, Patrick Couture, Shuaihua Pu, Jennifer A. Fleming, Sheila G. West, Penny M. Kris-Etherton, 2018, Journal of Nutrition on p. 721-728

Replication study: Systematic identification of genomic markers of drug sensitivity in cancer cells

John P. Vanden Heuvel, Ewa Maddox, Samar W. Maalouf, Elizabeth Iorns, Rachel Tsui, Alexandria Denis, Nicole Perfito, Timothy M. Errington, 2018, eLife

Effects of cranberry extracts on gene expression in THP-1 cells

Daniel B. Hannon, Jerry T. Thompson, Christina Khoo, Vijaya Juturu, John P. Vanden Heuvel, 2017, Food Science and Nutrition on p. 148-159

Therapeutic potential of GW501516 and the role of Peroxisome proliferator-activated receptor β/δ and B-cell lymphoma 6 in inflammatory signaling in human pancreatic cancer cells

Russell W. Smith, Jeffrey D. Coleman, Jerry T. Thompson, John P. Vanden Heuvel, 2016, Biochemistry and Biophysics Reports on p. 395-402

Biliverdin reductase A attenuates hepatic steatosis by inhibition of Glycogen Synthase Kinase (GSK) 3β phosphorylation of serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α

Terry D. Hinds, Katherine A. Burns, Peter A. Hosick, Lucien McBeth, Andrea Nestor-Kalinoski, Heather A. Drummond, Abdulhadi A. Alamodi, Michael W. Hankins, John P. Vanden Heuvel, David E. Stec, 2016, Journal of Biological Chemistry on p. 25179-25191

Registered report

John P. Vanden Heuvel, Jessica Bullenkamp, Elizabeth Iorns, William Gunn, Fraser Tan, Joelle Lomax, Nicole Perfito, Timothy Errington, 2016, eLife

Most-Cited Papers

Beef in an optimal lean diet study: Effects on lipids, lipoproteins, and apolipoproteins

Michael A. Roussell, Alison M. Hill, Trent L. Gaugler, Sheila G. West, John P. Vanden Heuvel, Petar Alaupovic, Peter J. Gillies, Penny M. Kris-Etherton, 2012, American Journal of Clinical Nutrition on p. 9-16

Biliverdin reductase A attenuates hepatic steatosis by inhibition of Glycogen Synthase Kinase (GSK) 3β phosphorylation of serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α

Terry D. Hinds, Katherine A. Burns, Peter A. Hosick, Lucien McBeth, Andrea Nestor-Kalinoski, Heather A. Drummond, Abdulhadi A. Alamodi, Michael W. Hankins, John P. Vanden Heuvel, David E. Stec, 2016, Journal of Biological Chemistry on p. 25179-25191

Effects of whole and refined grains in a weight-loss diet on markers of metabolic syndrome in individuals with increased waist circumference: A randomized controlled-feeding trial

Kristina Harris Jackson, Sheila G. West, John P. Vanden Heuvel, Satya S. Jonnalagadda, Alastair B. Ross, Alison M. Hill, Jessica A. Grieger, Susan K. Lemieux, Penny M. Kris-Etherton, 2014, American Journal of Clinical Nutrition on p. 577-586

Environmental and Human Health Impacts of Spreading Oil and Gas Wastewater on Roads

T. L. Tasker, W. D. Burgos, P. Piotrowski, L. Castillo-Meza, T. A. Blewett, K. B. Ganow, A. Stallworth, P. L.M. Delompré, G. G. Goss, L. B. Fowler, J. P. Vanden Heuvel, F. Dorman, N. R. Warner, 2018, Environmental Science & Technology on p. 7081-7091

Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors

Katie B. Paul, Jerry T. Thompson, Steven O. Simmons, John P. Vanden Heuvel, Kevin M. Crofton, 2013, Toxicology in Vitro on p. 2049-2060

Nutrigenomics and nutrigenetics of ω3 polyunsaturated fatty acids

John P. Vanden Heuvel, 2012, Progress in Molecular Biology and Translational Science on p. 75-112

Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action

Jun Zhang, Penny M. Kris-Etherton, Jerry T. Thompson, Daniel B. Hannon, Peter J. Gillies, John P. Vanden Heuvel, 2012, Nutrition Reports International on p. 400-409

Effects of a DASH-like diet containing lean beef on vascular health

M. A. Roussell, A. M. Hill, T. L. Gaugler, S. G. West, J. S. Ulbrecht, J. P. Vanden Heuvel, P. J. Gillies, P. M. Kris-Etherton, 2014, Journal of Human Hypertension on p. 600-605

Mechanistic examination of walnuts in prevention of breast cancer.

John P.Vanden Heuvel, Benjamin J. Belda, Dan B. Hannon, Penny M. Kris-Etherton, Jessica A. Grieger, Jun Zhang, Jerry T. Thompson, 2012, Nutrition and Cancer on p. 1078-1086

Regulation of inflammatory and lipid metabolism genes by eicosapentaenoic acid-rich oil

Peter J. Gillies, Sujata K. Bhatia, Leigh A. Belcher, Daniel B. Hannon, Jerry T. Thompson, John P. Vanden Heuvel, 2012, Journal of Lipid Research on p. 1679-1689