Jack Vanden Heuvel

Director of the Center for Excellence in Nutrigenomics; Professor of Molecular Toxicology

Jack Vanden Heuvel

Research Summary

Mechanisms of action of hypolipidemic drugs and peroxisome proliferators; steroid hormone receptor-mediated signal transduction; signal transduction by lipids and fatty acids; receptor-mediated carcinogenesis.

Huck Affiliations

Links

Publication Tags

Peroxisome Proliferator Activated Receptors Wastewater Liver Cells Xenobiotics Phosphorylation Serine Biliverdin Reductase Ppar Alpha Glycogen Synthase Kinase 3 Glycogen Synthase Kinases Pharmaceutical Preparations Prostaglandins Omega 3 Fatty Acids Gene Expression Cytoplasmic And Nuclear Receptors Diet Unsaturated Fatty Acids Neoplasms Proteins Cholesterol Toxicity Olaparib Rodentia Gw 501516

Most Recent Papers

Accumulating evidence to support the safe and efficacious use of a proprietary blend of capsaicinoids in mediating risk factors of obesity

Javahar Mariwala, Deshanie Rai, Ewa Maddox, Samar Maalouf, Kayla Smith, John Vanden Heuvel, J. Food & Nutr

Detection and removal of biologically active organic micropollutants from hospital wastewater

Luis Castillo Meza, Paulina Piotrowski, James Farnan, Travis L. Tasker, Boya Xiong, Benedikt Weggler, Kyra Murrell, Frank L. Dorman, John P. Vanden Heuvel, William D. Burgos, 2020, Science of the Total Environment

Environmental and Human Health Impacts of Spreading Oil and Gas Wastewater on Roads

T. L. Tasker, W. D. Burgos, P. Piotrowski, L. Castillo-Meza, T. A. Blewett, K. B. Ganow, A. Stallworth, P. L.M. Delompré, G. G. Goss, L. B. Fowler, J. P. Vanden Heuvel, F. Dorman, N. R. Warner, 2018, Environmental Science & Technology on p. 7081-7091

Diets low in saturated fat with different unsaturated fatty acid profiles similarly increase serum-mediated cholesterol efflux from THP-1 macrophages in a population with or at risk for metabolic syndrome: the canola oil multicenter intervention trial

Xiaoran Liu, Josephine Garban, Peter J. Jones, John Patrick Vanden Heuvel, Benoît Lamarche, David J. Jenkins, Philip W. Connelly, Patrick Couture, Shuaihua Pu, Jennifer Anne Fleming, Sheila Grace West, Penny Margaret Kris-Etherton, 2018, Journal of Nutrition on p. 721-728

Replication study: Systematic identification of genomic markers of drug sensitivity in cancer cells

John P. Vanden Heuvel, Ewa Maddox, Samar W. Maalouf, Elizabeth Iorns, Rachel Tsui, Alexandria Denis, Nicole Perfito, Timothy M. Errington, 2018, eLife

Effects of cranberry extracts on gene expression in THP-1 cells

Daniel B. Hannon, Jerry T. Thompson, Christina Khoo, Vijaya Juturu, John P. Vanden Heuvel, 2017, Food Science and Nutrition on p. 148-159

Therapeutic potential of GW501516 and the role of Peroxisome proliferator-activated receptor β/δ and B-cell lymphoma 6 in inflammatory signaling in human pancreatic cancer cells

Russell W. Smith, Jeffrey D. Coleman, Jerry T. Thompson, John P. Vanden Heuvel, 2016, Biochemistry and Biophysics Reports on p. 395-402

Biliverdin reductase A attenuates hepatic steatosis by inhibition of Glycogen Synthase Kinase (GSK) 3β phosphorylation of serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α

Terry D. Hinds, Katherine A. Burns, Peter A. Hosick, Lucien McBeth, Andrea Nestor-Kalinoski, Heather A. Drummond, Abdulhadi A. Alamodi, Michael W. Hankins, John P. Vanden Heuvel, David E. Stec, 2016, Journal of Biological Chemistry on p. 25179-25191

Registered report

John P. Vanden Heuvel, Jessica Bullenkamp, Elizabeth Iorns, William Gunn, Fraser Tan, Joelle Lomax, Nicole Perfito, Timothy Errington, 2016, eLife

Effects of cranberry extracts on gene expression in THP-1 cells.

D Hannon, J Thompson, C Khoo, V Juturu, John Vanden Heuvel, 2016, Food science & nutrition on p. 148-159

Most-Cited Papers

Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia.

Ann Skulas-Ray, Penny Kris-Etherton, W Harris, John Vanden Heuvel, P Wagner, Sheila West, 2011, American Journal of Clinical Nutrition on p. 243-52

Xenobiotic metabolism, disposition, and regulation by receptors

Curtis J. Omiecinski, John P. Vanden Heuvel, Gary H. Perdew, Jeffrey M. Peters, 2011, Toxicological Sciences on p. S49-S75

Beef in an optimal lean diet study: Effects on lipids, lipoproteins, and apolipoproteins

Michael A. Roussell, Alison M. Hill, Trent L. Gaugler, Sheila G. West, John P. Vanden Heuvel, Petar Alaupovic, Peter J. Gillies, Penny M. Kris-Etherton, 2012, American Journal of Clinical Nutrition on p. 9-16

Δ <sup>12</sup>-prostaglandin J <sub>3</sub>, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice

Shailaja Hegde, Naveen Kaushal, Kodihalli C. Ravindra, Christopher Chiaro, Kelsey T. Hafer, Ujjawal H. Gandhi, Jerry T. Thompson, John Patrick Vanden Heuvel, Mary J. Kennett, Pamela Hankey Giblin, Robert Paulson, Kumble Sandeep Prabhu, 2011, Blood on p. 6909-6919

Biliverdin reductase A attenuates hepatic steatosis by inhibition of Glycogen Synthase Kinase (GSK) 3β phosphorylation of serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α

Terry D. Hinds, Katherine A. Burns, Peter A. Hosick, Lucien McBeth, Andrea Nestor-Kalinoski, Heather A. Drummond, Abdulhadi A. Alamodi, Michael W. Hankins, John P. Vanden Heuvel, David E. Stec, 2016, Journal of Biological Chemistry on p. 25179-25191

Effects of whole and refined grains in a weight-loss diet on markers of metabolic syndrome in individuals with increased waist circumference: A randomized controlled-feeding trial

Kristina Harris Jackson, Sheila G. West, John P. Vanden Heuvel, Satya S. Jonnalagadda, Alastair B. Ross, Alison M. Hill, Jessica A. Grieger, Susan K. Lemieux, Penny M. Kris-Etherton, 2014, American Journal of Clinical Nutrition on p. 577-586

Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors

Katie B. Paul, Jerry T. Thompson, Steven O. Simmons, John Patrick Vanden Heuvel, Kevin M. Crofton, 2013, Toxicology in Vitro on p. 2049-2060

Development of a cell-based, high-throughput screening assay for cholesterol efflux using a fluorescent mimic of cholesterol

Jun Zhang, Sutang Cai, Blake R. Peterson, Penny Margaret Kris-Etherton, John Patrick Vanden Heuvel, 2011, Assay and Drug Development Technologies on p. 136-146

Nutrigenomics and nutrigenetics of ω3 polyunsaturated fatty acids

John P. Vanden Heuvel, 2012, Progress in Molecular Biology and Translational Science on p. 75-112

15-deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub>-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor γ

Priyadarshini Raman, Barbara L.F. Kaplan, Jerry T. Thompson, John P. Vanden Heuvel, Norbert E. Kaminski, 2011, Molecular Pharmacology on p. 201-209