Jack Vanden Heuvel
Director of the Center for Excellence in Nutrigenomics; Professor of Molecular Toxicology
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204 Huck Life Sciences
University Park, PA - jpv2@psu.edu
- 814-863-8532
Research Summary
Mechanisms of action of hypolipidemic drugs and peroxisome proliferators; steroid hormone receptor-mediated signal transduction; signal transduction by lipids and fatty acids; receptor-mediated carcinogenesis.
Huck Affiliations
Links
Publication Tags
Macrophages Peroxisome Proliferator Activated Receptors Cholesterol Liver Cells Glycogen Synthase Kinases Phosphorylation Serine Biliverdin Reductase Ppar Alpha Glycogen Synthase Kinase 3 Pharmaceutical Preparations Prostaglandins Wastewater Stearoyl Coa Desaturase Unsaturated Fatty Acids Gene Expression Cytoplasmic And Nuclear Receptors Neoplasms Omega 3 Fatty Acids Alpha Linolenic Acid Foam Cells Genes Waist Circumference ProteinsMost Recent Papers
Detection and removal of biologically active organic micropollutants from hospital wastewater
Luis Castillo Meza, Paulina Piotrowski, James Farnan, Travis L. Tasker, Boya Xiong, Benedikt Weggler, Kyra Murrell, Frank L. Dorman, John P. Vanden Heuvel, William D. Burgos, 2020, Science of the Total Environment
Diets low in saturated fat with different unsaturated fatty acid profiles similarly increase serum-mediated cholesterol efflux from THP-1 macrophages in a population with or at risk for metabolic syndrome
Xiaoran Liu, Josephine Garban, Peter J. Jones, John Patrick Vanden Heuvel, Benoît Lamarche, David J. Jenkins, Philip W. Connelly, Patrick Couture, Shuaihua Pu, Jennifer Anne Fleming, Sheila Grace West, Penny Margaret Kris-Etherton, 2018, Journal of Nutrition on p. 721-728
Replication study
John P. Vanden Heuvel, Ewa Maddox, Samar W. Maalouf, Elizabeth Iorns, Rachel Tsui, Alexandria Denis, Nicole Perfito, Timothy M. Errington, 2018, eLife
Effects of cranberry extracts on gene expression in THP-1 cells
Daniel B. Hannon, Jerry T. Thompson, Christina Khoo, Vijaya Juturu, John P. Vanden Heuvel, 2017, Food Science and Nutrition on p. 148-159
Therapeutic potential of GW501516 and the role of Peroxisome proliferator-activated receptor β/δ and B-cell lymphoma 6 in inflammatory signaling in human pancreatic cancer cells
Russell W. Smith, Jeffrey D. Coleman, Jerry T. Thompson, John Patrick Vanden Heuvel, 2016, Biochemistry and Biophysics Reports on p. 395-402
Biliverdin reductase A attenuates hepatic steatosis by inhibition of Glycogen Synthase Kinase (GSK) 3β phosphorylation of serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α
Terry D. Hinds, Katherine A. Burns, Peter A. Hosick, Lucien McBeth, Andrea Nestor-Kalinoski, Heather A. Drummond, Abdulhadi A. Alamodi, Michael W. Hankins, John P. Vanden Heuvel, David E. Stec, 2016, Journal of Biological Chemistry on p. 25179-25191
Registered report
John P. Vanden Heuvel, Jessica Bullenkamp, Elizabeth Iorns, William Gunn, Fraser Tan, Joelle Lomax, Nicole Perfito, Timothy Errington, 2016, eLife
Effects of cranberry extracts on gene expression in THP-1 cells.
D Hannon, Jerry Thompson, C Khoo, V Juturu, John Vanden Heuvel, 2016, Food science & nutrition on p. 148-159
Differential nucleobase protection against 5-fluorouracil toxicity for squamous and columnar cells: Implication for tissue function and oncogenesis
John Patrick Vanden Heuvel, Jerry T. Thompson, Prajakta Albrecht, Donald Mandetta, Harry Kamerow, John P. Ford, 2015, Investigational New Drugs on p. 1003-1011
Effects of whole and refined grains in a weight-loss diet on markers of metabolic syndrome in individuals with increased waist circumference
Kristina Harris Jackson, Sheila G. West, John P. Vanden Heuvel, Satya S. Jonnalagadda, Alastair B. Ross, Alison M. Hill, Jessica A. Grieger, Susan K. Lemieux, Penny M. Kris-Etherton, 2014, American Journal of Clinical Nutrition on p. 577-586
Most-Cited Papers
Δ <sup>12</sup>-prostaglandin J <sub>3</sub>, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice
Shailaja Hegde, Naveen Kaushal, Kodihalli C. Ravindra, Christopher Chiaro, Kelsey T. Hafer, Ujjawal H. Gandhi, Jerry T. Thompson, John Patrick Vanden Heuvel, Mary J. Kennett, Pamela Hankey Giblin, Robert Paulson, Kumble Sandeep Prabhu, 2011, Blood on p. 6909-6919
Development of a cell-based, high-throughput screening assay for cholesterol efflux using a fluorescent mimic of cholesterol
Jun Zhang, Sutang Cai, Blake R. Peterson, Penny Margaret Kris-Etherton, John Patrick Vanden Heuvel, 2011, Assay and Drug Development Technologies on p. 136-146
Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors
Katie B. Paul, Jerry T. Thompson, Steven O. Simmons, John Patrick Vanden Heuvel, Kevin M. Crofton, 2013, Toxicology in Vitro on p. 2049-2060
Effects of whole and refined grains in a weight-loss diet on markers of metabolic syndrome in individuals with increased waist circumference
Kristina Harris Jackson, Sheila G. West, John P. Vanden Heuvel, Satya S. Jonnalagadda, Alastair B. Ross, Alison M. Hill, Jessica A. Grieger, Susan K. Lemieux, Penny M. Kris-Etherton, 2014, American Journal of Clinical Nutrition on p. 577-586
Biliverdin reductase A attenuates hepatic steatosis by inhibition of Glycogen Synthase Kinase (GSK) 3β phosphorylation of serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α
Terry D. Hinds, Katherine A. Burns, Peter A. Hosick, Lucien McBeth, Andrea Nestor-Kalinoski, Heather A. Drummond, Abdulhadi A. Alamodi, Michael W. Hankins, John P. Vanden Heuvel, David E. Stec, 2016, Journal of Biological Chemistry on p. 25179-25191
Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression
Jun Zhang, Penny M. Kris-Etherton, Jerry T. Thompson, Daniel B. Hannon, Peter J. Gillies, John P. Vanden Heuvel, 2012, Journal of Nutritional Biochemistry on p. 400-409
Nutrigenomics and nutrigenetics of ω3 polyunsaturated fatty acids
John P. Vanden Heuvel, 2012, Progress in Molecular Biology and Translational Science on p. 75-112
15-deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub>-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor γ
Priyadarshini Raman, Barbara L.F. Kaplan, Jerry T. Thompson, John P. Vanden Heuvel, Norbert E. Kaminski, 2011, Molecular pharmacology on p. 201-209
Inhibition of macrophage adhesion activity by 9trans,11trans-conjugated linoleic acid
Yunkyoung Lee, John Patrick Vanden Heuvel, 2010, Journal of Nutritional Biochemistry on p. 490-497
Walnut oil increases cholesterol efflux through inhibition of stearoyl CoA desaturase 1 in THP-1 macrophage-derived foam cells
Jun Zhang, Jessica A. Grieger, Penny Margaret Kris-Etherton, Jerry T. Thompson, Peter J. Gillies, Jennifer Anne Fleming, John Patrick Vanden Heuvel, 2011, Nutrition and Metabolism