Jack Vanden Heuvel

Director of the Center for Excellence in Nutrigenomics; Professor of Molecular Toxicology

Jack Vanden Heuvel

Research Summary

Mechanisms of action of hypolipidemic drugs and peroxisome proliferators; steroid hormone receptor-mediated signal transduction; signal transduction by lipids and fatty acids; receptor-mediated carcinogenesis.

Huck Affiliations

Links

Publication Tags

Cholesterol Diet Macrophages Pharmaceutical Preparations Omega 3 Fatty Acids Prostaglandins Cells Liver Unsaturated Fatty Acids Gene Expression Neoplasms Cytoplasmic And Nuclear Receptors Triglycerides Therapeutics Health Alpha Linolenic Acid Waist Circumference Xenobiotics Genes Whole Grains Wastewater Rodentia Ppar Alpha Stearoyl Coa Desaturase Stem Cells

Most Recent Papers

Environmental and Human Health Impacts of Spreading Oil and Gas Wastewater on Roads

T. L. Tasker, William D. Burgos, P. Piotrowski, L. Castillo-Meza, T. A. Blewett, K. B. Ganow, A. Stallworth, P. L.M. Delompré, G. G. Goss, Lara Burgel Fowler, John Patrick Vanden Heuvel, Franklin Lewis Dorman, Jr., Nathaniel Richard Warner, 2018, Environmental Science and Technology on p. 7081-7091

Diets low in saturated fat with different unsaturated fatty acid profiles similarly increase serum-mediated cholesterol efflux from THP-1 macrophages in a population with or at risk for metabolic syndrome

Xiaoran Liu, Josephine Garban, Peter J. Jones, John Patrick Vanden Heuvel, Benoît Lamarche, David J. Jenkins, Philip W. Connelly, Patrick Couture, Shuaihua Pu, Jennifer Anne Fleming, Sheila Grace West, Penny Margaret Kris-Etherton, 2018, Journal of Nutrition on p. 721-728

Replication study

John Patrick Vanden Heuvel, Ewa Maddox, Samar W. Maalouf, Elizabeth Iorns, Rachel Tsui, Alexandria Denis, Nicole Perfito, Timothy M. Errington, 2018, eLife

Effects of cranberry extracts on gene expression in THP-1 cells

Daniel B. Hannon, Jerry T. Thompson, Christina Khoo, Vijaya Juturu, John Patrick Vanden Heuvel, 2017, Food Science and Nutrition on p. 148-159

Therapeutic potential of GW501516 and the role of Peroxisome proliferator-activated receptor β/δ and B-cell lymphoma 6 in inflammatory signaling in human pancreatic cancer cells

Russell W. Smith, Jeffrey D. Coleman, Jerry T. Thompson, John Patrick Vanden Heuvel, 2016, Biochemistry and Biophysics Reports on p. 395-402

Biliverdin reductase A attenuates hepatic steatosis by inhibition of Glycogen Synthase Kinase (GSK) 3β phosphorylation of serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α

Terry D. Hinds, Katherine A. Burns, Peter A. Hosick, Lucien McBeth, Andrea Nestor-Kalinoski, Heather A. Drummond, Abdulhadi A. Alamodi, Michael W. Hankins, John Patrick Vanden Heuvel, David E. Stec, 2016, Journal of Biological Chemistry on p. 25179-25191

Registered report

John P. Vanden Heuvel, John Patrick Vanden Heuvel, Elizabeth Iorns, William Gunn, Fraser Tan, Joelle Lomax, Nicole Perfito, Timothy Errington, 2016, eLife

Differential nucleobase protection against 5-fluorouracil toxicity for squamous and columnar cells

John Patrick Vanden Heuvel, Jerry T. Thompson, Prajakta Albrecht, Donald Mandetta, Harry Kamerow, John P. Ford, 2015, Investigational New Drugs on p. 1003-1011

Effects of a DASH-like diet containing lean beef on vascular health

M. A. Roussell, A. M. Hill, T. L. Gaugler, Sheila Grace West, Jan Ulbrecht, John Patrick Vanden Heuvel, P. J. Gillies, Penny Margaret Kris-Etherton, 2014, Journal of Human Hypertension on p. 600-605

Effects of whole and refined grains in a weight-loss diet on markers of metabolic syndrome in individuals with increased waist circumference

Kristina Harris Jackson, Sheila Grace West, John Patrick Vanden Heuvel, Satya S. Jonnalagadda, Alastair B. Ross, Alison M. Hill, Jessica A. Grieger, Susan K. Lemieux, Penny Margaret Kris-Etherton, 2014, American Journal of Clinical Nutrition on p. 577-586

High-Impact Papers

Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia

Ann C. Skulas-Ray, Penny Margaret Kris-Etherton, William S. Harris, John Patrick Vanden Heuvel, Paul R. Wagner, Sheila Grace West, 2011, American Journal of Clinical Nutrition on p. 243-252

Beef in an Optimal Lean Diet study

Michael A. Roussell, Alison M. Hill, Trent L. Gaugler, Sheila G. West, John P. Vanden Heuvel, Petar Alaupovic, Peter J. Gillies, Penny M. Kris-Etherton, 2012, American Journal of Clinical Nutrition on p. 9-16

Δ <sup>12</sup>-prostaglandin J <sub>3</sub>, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice

Shailaja Hegde, Naveen Kaushal, Kodihalli C. Ravindra, Christopher Chiaro, Kelsey T. Hafer, Ujjawal H. Gandhi, Jerry T. Thompson, John Patrick Vanden Heuvel, Mary J. Kennett, Pamela Hankey Giblin, Robert Paulson, Kumble Sandeep Prabhu, 2011, Blood on p. 6909-6919

Development of a cell-based, high-throughput screening assay for cholesterol efflux using a fluorescent mimic of cholesterol

Jun Zhang, Sutang Cai, Blake R. Peterson, Penny Margaret Kris-Etherton, John Patrick Vanden Heuvel, 2011, Assay and Drug Development Technologies on p. 136-146

Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors

Katie B. Paul, Jerry T. Thompson, Steven O. Simmons, John Patrick Vanden Heuvel, Kevin M. Crofton, 2013, Toxicology in Vitro on p. 2049-2060

Effects of whole and refined grains in a weight-loss diet on markers of metabolic syndrome in individuals with increased waist circumference

Kristina Harris Jackson, Sheila Grace West, John Patrick Vanden Heuvel, Satya S. Jonnalagadda, Alastair B. Ross, Alison M. Hill, Jessica A. Grieger, Susan K. Lemieux, Penny Margaret Kris-Etherton, 2014, American Journal of Clinical Nutrition on p. 577-586

Nutrigenomics and nutrigenetics of ω3 polyunsaturated fatty acids

John P. Vanden Heuvel, 2012, Progress in Molecular Biology and Translational Science on p. 75-112

Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression

Jun Zhang, Penny Margaret Kris-Etherton, Jerry T. Thompson, Daniel B. Hannon, Peter J. Gillies, John Patrick Vanden Heuvel, 2012, Journal of Nutritional Biochemistry on p. 400-409

15-deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub>-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor γ

Priyadarshini Raman, Barbara L.F. Kaplan, Jerry T. Thompson, John Patrick Vanden Heuvel, Norbert E. Kaminski, 2011, Molecular Pharmacology on p. 201-209

A High antioxidant spice blend attenuates postprandial insulin and triglyceride responses and increases some plasma measures of antioxidant activity in healthy, overweight men

Ann C. Skulas-Ray, Penny Margaret Kris-Etherton, Danette L. Teeter, C. Y.Oliver Chen, John Patrick Vanden Heuvel, Sheila Grace West, 2011, Journal of Nutrition on p. 1451-1457