Jack Vanden Heuvel
Director of the Center for Excellence in Nutrigenomics; Professor of Molecular Toxicology
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204 Huck Life Sciences
University Park, PA - jpv2@psu.edu
- 814-863-8532
Research Summary
Mechanisms of action of hypolipidemic drugs and peroxisome proliferators; steroid hormone receptor-mediated signal transduction; signal transduction by lipids and fatty acids; receptor-mediated carcinogenesis.
Huck Affiliations
Links
Publication Tags
Peroxisome Proliferator Activated Receptors Wastewater Liver Oils Genes Gene Expression Cells Ppar Alpha Glycogen Synthase Kinase 3 Phosphorylation Biliverdin Reductase Glycogen Synthase Kinases Serine Diet Macrophages Health Stearoyl Coa Desaturase Cytoplasmic And Nuclear Receptors Cholesterol Pharmaceutical Preparations Proteins Alpha Linolenic Acid Lipid Metabolism Neoplasms Unsaturated Fatty AcidsMost Recent Papers
Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer
Kun Ming Chen, Henry Thompson, John P. Vanden-Heuvel, Yuan Wan Sun, Neil Trushin, Cesar Aliaga, Krishne Gowda, Shantu Amin, Bruce Stanley, Andrea Manni, Karam El-Bayoumy, 2021, Scientific Reports
Accumulating evidence to support the safe and efficacious use of a proprietary blend of capsaicinoids in mediating risk factors for obesity
Javahar Kohli Mariwala, Deshanie Rai, Muralidhara Padigaru, Abhijeet Ashok Morde, Ewa Maddox, Samar Maalouf, Kayla Smith, John P. Vanden Heuvel, 2021, Food Science and Nutrition on p. 2823-2835
Detection and removal of biologically active organic micropollutants from hospital wastewater
Luis Castillo Meza, Paulina Piotrowski, James Farnan, Travis L. Tasker, Boya Xiong, Benedikt Weggler, Kyra Murrell, Franklin Lewis Dorman, Jr., John P. Vanden Heuvel, William D. Burgos, 2020, Science of the Total Environment
Environmental and Human Health Impacts of Spreading Oil and Gas Wastewater on Roads
T. L. Tasker, W. D. Burgos, P. Piotrowski, L. Castillo-Meza, T. A. Blewett, K. B. Ganow, A. Stallworth, P. L.M. Delompré, G. G. Goss, L. B. Fowler, J. P. Vanden Heuvel, F. Dorman, N. R. Warner, 2018, Environmental Science & Technology on p. 7081-7091
Diets low in saturated fat with different unsaturated fatty acid profiles similarly increase serum-mediated cholesterol efflux from THP-1 macrophages in a population with or at risk for metabolic syndrome: the canola oil multicenter intervention trial
Xiaoran Liu, Josephine Garban, Peter J. Jones, Jack Vanden Heuvel, Benoît Lamarche, David J. Jenkins, Philip W. Connelly, Patrick Couture, Shuaihua Pu, Jennifer A. Fleming, Sheila G. West, Penny M. Kris-Etherton, 2018, Journal of Nutrition on p. 721-728
Replication study: Systematic identification of genomic markers of drug sensitivity in cancer cells
John P. Vanden Heuvel, Ewa Maddox, Samar W. Maalouf, Elizabeth Iorns, Rachel Tsui, Alexandria Denis, Nicole Perfito, Timothy M. Errington, 2018, eLife
Effects of cranberry extracts on gene expression in THP-1 cells
Daniel B. Hannon, Jerry T. Thompson, Christina Khoo, Vijaya Juturu, John P. Vanden Heuvel, 2017, Food Science and Nutrition on p. 148-159
Therapeutic potential of GW501516 and the role of Peroxisome proliferator-activated receptor β/δ and B-cell lymphoma 6 in inflammatory signaling in human pancreatic cancer cells
Russell W. Smith, Jeffrey D. Coleman, Jerry T. Thompson, John P. Vanden Heuvel, 2016, Biochemistry and Biophysics Reports on p. 395-402
Biliverdin reductase A attenuates hepatic steatosis by inhibition of Glycogen Synthase Kinase (GSK) 3β phosphorylation of serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α
Terry D. Hinds, Katherine A. Burns, Peter A. Hosick, Lucien McBeth, Andrea Nestor-Kalinoski, Heather A. Drummond, Abdulhadi A. Alamodi, Michael W. Hankins, John P. Vanden Heuvel, David E. Stec, 2016, Journal of Biological Chemistry on p. 25179-25191
Registered report
John P. Vanden Heuvel, Jessica Bullenkamp, Elizabeth Iorns, William Gunn, Fraser Tan, Joelle Lomax, Nicole Perfito, Timothy Errington, 2016, eLife
Most-Cited Papers
Beef in an optimal lean diet study: Effects on lipids, lipoproteins, and apolipoproteins
Michael A. Roussell, Alison M. Hill, Trent L. Gaugler, Sheila G. West, John P. Vanden Heuvel, Petar Alaupovic, Peter J. Gillies, Penny M. Kris-Etherton, 2012, American Journal of Clinical Nutrition on p. 9-16
Biliverdin reductase A attenuates hepatic steatosis by inhibition of Glycogen Synthase Kinase (GSK) 3β phosphorylation of serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α
Terry D. Hinds, Katherine A. Burns, Peter A. Hosick, Lucien McBeth, Andrea Nestor-Kalinoski, Heather A. Drummond, Abdulhadi A. Alamodi, Michael W. Hankins, John P. Vanden Heuvel, David E. Stec, 2016, Journal of Biological Chemistry on p. 25179-25191
Effects of whole and refined grains in a weight-loss diet on markers of metabolic syndrome in individuals with increased waist circumference: A randomized controlled-feeding trial
Kristina Harris Jackson, Sheila G. West, John P. Vanden Heuvel, Satya S. Jonnalagadda, Alastair B. Ross, Alison M. Hill, Jessica A. Grieger, Susan K. Lemieux, Penny M. Kris-Etherton, 2014, American Journal of Clinical Nutrition on p. 577-586
Environmental and Human Health Impacts of Spreading Oil and Gas Wastewater on Roads
T. L. Tasker, W. D. Burgos, P. Piotrowski, L. Castillo-Meza, T. A. Blewett, K. B. Ganow, A. Stallworth, P. L.M. Delompré, G. G. Goss, L. B. Fowler, J. P. Vanden Heuvel, F. Dorman, N. R. Warner, 2018, Environmental Science & Technology on p. 7081-7091
Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors
Katie B. Paul, Jerry T. Thompson, Steven O. Simmons, John P. Vanden Heuvel, Kevin M. Crofton, 2013, Toxicology in Vitro on p. 2049-2060
Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action
Jun Zhang, Penny M. Kris-Etherton, Jerry T. Thompson, Daniel B. Hannon, Peter J. Gillies, John P. Vanden Heuvel, 2012, Nutrition Reports International on p. 400-409
Nutrigenomics and nutrigenetics of ω3 polyunsaturated fatty acids
John P. Vanden Heuvel, 2012, Progress in Molecular Biology and Translational Science on p. 75-112
Effects of a DASH-like diet containing lean beef on vascular health
M. A. Roussell, A. M. Hill, T. L. Gaugler, S. G. West, J. S. Ulbrecht, J. P. Vanden Heuvel, P. J. Gillies, P. M. Kris-Etherton, 2014, Journal of Human Hypertension on p. 600-605
Mechanistic examination of walnuts in prevention of breast cancer.
John P.Vanden Heuvel, Benjamin J. Belda, Dan B. Hannon, Penny M. Kris-Etherton, Jessica A. Grieger, Jun Zhang, Jerry T. Thompson, 2012, Nutrition and Cancer on p. 1078-1086
Regulation of inflammatory and lipid metabolism genes by eicosapentaenoic acid-rich oil
Peter J. Gillies, Sujata K. Bhatia, Leigh A. Belcher, Daniel B. Hannon, Jerry T. Thompson, John P. Vanden Heuvel, 2012, Journal of Lipid Research on p. 1679-1689