Melanie McReynolds

Huck Early Career Chair in Biochemistry and Molecular Biology; Assistant Professor of Biochemistry and Molecular Biology

Melanie McReynolds

Research Summary

The biochemistry behind aging and its intersection with stress, with the long-term goal of identifying strategies that promote healthier aging.

Huck Affiliations

Links

Publication Tags

Nad Metabolomics Mentoring Time Metabolite Technology Mentors Mathematics Environment Pharmacological Metabolism Glucose Brain Pandemics Isotopes Isotope Mass Spectrometry Genes Metabolic Respiration Enzymes Kidney Population Stem Cells Interviews Pipeline

Most Recent Papers

NAD<sup>+</sup> Flux and Resiliency in Aged Mice

Melanie R. McReynolds, 2022, FASEB Journal

Spatially resolved isotope tracing reveals tissue metabolic activity

Lin Wang, Xi Xing, Xianfeng Zeng, S. Ra Elle Jackson, Tara TeSlaa, Osama Al-Dalahmah, Laith Z. Samarah, Katharine Goodwin, Lifeng Yang, Melanie R. McReynolds, Xiaoxuan Li, Jeremy J. Wolff, Joshua D. Rabinowitz, Shawn M. Davidson, 2022, Nature Methods on p. 223-230

Combining Metabolomics and Experimental Evolution Reveals Key Mechanisms Underlying Longevity Differences in Laboratory Evolved Drosophila melanogaster Populations

Mark A. Phillips, Kenneth R. Arnold, Zer Vue, Heather K. Beasley, Edgar Garza-Lopez, Andrea G. Marshall, Derrick J. Morton, Melanie R. McReynolds, Thomas T. Barter, Antentor Hinton, 2022, International Journal of Molecular Sciences

Using virtual interviewing to create a more accessible hybrid academic job market

Christina M. Termini, Florentine U.N. Rutaganira, Caroline B. Palavicino-Maggio, Chelsey C. Spriggs, Chantell S. Evans, Melanie R. McReynolds, 2021, Cell on p. 6217-6221

NAD<sup>+</sup> flux is maintained in aged mice despite lower tissue concentrations

Melanie R. McReynolds, Karthikeyani Chellappa, Eric Chiles, Connor Jankowski, Yihui Shen, Li Chen, Hélène C. Descamps, Sarmistha Mukherjee, Yashaswini R. Bhat, Siddharth R. Lingala, Qingwei Chu, Paul Botolin, Faisal Hayat, Tomohito Doke, Katalin Susztak, Christoph A. Thaiss, Wenyun Lu, Marie E. Migaud, Xiaoyang Su, Joshua D. Rabinowitz, Joseph A. Baur, 2021, Cell Systems on p. 1160-1172.e4

Cell size is a determinant of stem cell potential during aging

Jette Lengefeld, Chia Wei Cheng, Pema Maretich, Marguerite Blair, Hannah Hagen, Melanie R. McReynolds, Emily Sullivan, Kyra Majors, Christina Roberts, Joon Ho Kang, Joachim D. Steiner, Teemu P. Miettinen, Scott R. Manalis, Adam Antebi, Sean J. Morrison, Jacqueline A. Lees, Laurie A. Boyer, Ömer H. Yilmaz, Angelika Amon, 2021, Science advances

Metabolite discovery through global annotation of untargeted metabolomics data

Li Chen, Wenyun Lu, Lin Wang, Xi Xing, Ziyang Chen, Xin Teng, Xianfeng Zeng, Antonio D. Muscarella, Yihui Shen, Alexis Cowan, Melanie R. McReynolds, Brandon J. Kennedy, Ashley M. Lato, Shawn R. Campagna, Mona Singh, Joshua D. Rabinowitz, 2021, Nature Methods on p. 1377-1385

Responding and navigating racialized microaggressions in STEM

Andrea Marshall, Angela D. Pack, Sarah Afua Owusu, Rainbo Hultman, David Drake, Florentine U.N. Rutaganira, Maria Namwanje, Chantell S. Evans, Edgar Garza-Lopez, Samantha C. Lewis, Christina M. Termini, Salma AshShareef, Innes Hicsasmaz, Brittany Taylor, Melanie R. McReynolds, Haysetta Shuler, Antentor O. Hinton, 2021, FEMS Immunology and Medical Microbiology

NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma

Tanya Schild, Melanie R. McReynolds, Christie Shea, Vivien Low, Bethany E. Schaffer, John M. Asara, Elena Piskounova, Noah Dephoure, Joshua D. Rabinowitz, Ana P. Gomes, John Blenis, 2021, Cell Reports

Mentoring during Uncertain Times

Christina M. Termini, Melanie R. McReynolds, Florentine U.N. Rutaganira, Re Anna S. Roby, Antentor O. Hinton, Calvin S. Carter, Sunny C. Huang, Zer Vue, Denise Martinez, Haysetta D. Shuler, Brittany L. Taylor, 2021, Trends in Biochemical Sciences on p. 345-348

Most-Cited Papers

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

Paras S. Minhas, Amira Latif-Hernandez, Melanie R. McReynolds, Aarooran S. Durairaj, Qian Wang, Amanda Rubin, Amit U. Joshi, Joy Q. He, Esha Gauba, Ling Liu, Congcong Wang, Miles Linde, Yuki Sugiura, Peter K. Moon, Ravi Majeti, Makoto Suematsu, Daria Mochly-Rosen, Irving L. Weissman, Frank M. Longo, Joshua D. Rabinowitz, Katrin I. Andreasson, 2021, Nature on p. 122-128

SLC25A51 is a mammalian mitochondrial NAD<sup>+</sup> transporter

Timothy S. Luongo, Jared M. Eller, Mu Jie Lu, Marc Niere, Fabio Raith, Caroline Perry, Marc R. Bornstein, Paul Oliphint, Lin Wang, Melanie R. McReynolds, Marie E. Migaud, Joshua D. Rabinowitz, F. Brad Johnson, Kai Johnsson, Mathias Ziegler, Xiaolu A. Cambronne, Joseph A. Baur, 2020, Nature on p. 174-179

Serine Catabolism Feeds NADH when Respiration Is Impaired

Lifeng Yang, Juan Carlos Garcia Canaveras, Zihong Chen, Lin Wang, Lingfan Liang, Cholsoon Jang, Johannes A. Mayr, Zhaoyue Zhang, Jonathan M. Ghergurovich, Le Zhan, Shilpy Joshi, Zhixian Hu, Melanie R. McReynolds, Xiaoyang Su, Eileen White, Raphael J. Morscher, Joshua D. Rabinowitz, 2020, Cell Metabolism on p. 809-821.e6

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD<sup>+</sup> and NMN levels

Claudia C.S. Chini, Thais R. Peclat, Gina M. Warner, Sonu Kashyap, Jair Machado Espindola-Netto, Guilherme C. de Oliveira, Lilian S. Gomez, Kelly A. Hogan, Mariana G. Tarragó, Amrutesh S. Puranik, Guillermo Agorrody, Katie L. Thompson, Kevin Dang, Starlynn Clarke, Bennett G. Childs, Karina S. Kanamori, Micaela A. Witte, Paola Vidal, Anna L. Kirkland, Marco De Cecco, Karthikeyani Chellappa, Melanie R. McReynolds, Connor Jankowski, Tamara Tchkonia, James L. Kirkland, John M. Sedivy, Jan M. van Deursen, Darren J. Baker, Wim van Schooten, Joshua D. Rabinowitz, Joseph A. Baur, Eduardo N. Chini, 2020, Nature Metabolism on p. 1284-1304

Age-related NAD<sup>+</sup> decline

Melanie R. McReynolds, Karthikeyani Chellappa, Joseph A. Baur, 2020, Experimental Gerontology

Patching the Leaks

Antentor O. Hinton, Christina M. Termini, Elsie C. Spencer, Florentine U.N. Rutaganira, Daphney Chery, Re Ana Roby, Zer Vue, Angela D. Pack, Lillian J. Brady, Edgar Garza-Lopez, Andrea G. Marshall, Samantha C. Lewis, Haysetta D. Shuler, Brittany L. Taylor, Melanie R. McReynolds, Caroline B. Palavicino-Maggio, 2020, Cell on p. 568-575

Mentoring minority trainees

Antentor O. Hinton, Zer Vue, Christina M. Termini, Brittany L. Taylor, Haysetta D. Shuler, Melanie R. McReynolds, 2020, EMBO Reports

The art of virtual mentoring in the twenty-first century for STEM majors and beyond

Melanie R. McReynolds, Christina M. Termini, Antentor O. Hinton, Brittany L. Taylor, Zer Vue, Sunny C. Huang, Re Anna S. Roby, Haysetta Shuler, Calvin S. Carter, 2020, Nature Biotechnology on p. 1477-1482

Mentoring during Uncertain Times

Christina M. Termini, Melanie R. McReynolds, Florentine U.N. Rutaganira, Re Anna S. Roby, Antentor O. Hinton, Calvin S. Carter, Sunny C. Huang, Zer Vue, Denise Martinez, Haysetta D. Shuler, Brittany L. Taylor, 2021, Trends in Biochemical Sciences on p. 345-348

Improved Annotation of Untargeted Metabolomics Data through Buffer Modifications That Shift Adduct Mass and Intensity

Wenyun Lu, Xi Xing, Lin Wang, Li Chen, Sisi Zhang, Melanie R. McReynolds, Joshua D. Rabinowitz, 2020, Analytical Chemistry on p. 11573-11581