Melanie McReynolds

Huck Early Career Chair in Biochemistry and Molecular Biology; Assistant Professor of Biochemistry and Molecular Biology

Melanie McReynolds

Research Summary

The biochemistry behind aging and its intersection with stress, with the long-term goal of identifying strategies that promote healthier aging.

Huck Graduate Students

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Nad Glass Metabolic Pharmacological Metabolism Glucose Brain Mass Spectrometry Isotopes Metabolite Respiration Isotope Pipeline Cognitive Dysfunction Nadp Transducers Cell Size Metabolomics Nicotinamide Mononucleotide Citric Acid Cycle Lipid Mathematics Enzymes Ketogenic Diet Neoplasm Metastasis Serine

Most Recent Publications

Latent transforming growth factor beta binding protein 4: A regulator of mitochondrial function in acute kidney injury

Kit Neikirk, Adaku Ume, Praveena Prasad, Andrea Marshall, Jananie Rockwood, Tara-Yesomi Wenegieme, Kelia McMichael, Melanie McReynolds, Clintoria Williams, Antentor Hinton, Jr., Aging Cell on p. e14019

3D reconstruction of murine mitochondria reveals changes in structure during aging linked to the MICOS complex

Zer Vue, Edgar Garza-Lopez, Kit Neikirk, Prasanna Katti, Larry Vang, Heather Beasley, Jianqiang Shao, Andrea Marshall, Amber Crabtree, Alexandria Murphy, Brenita Jenkins, Praveena Prasad, Chantell Evans, Brittany Taylor, Margaret Mungai, Mason Killion, Dominique Stephens, Trace Christensen, Jacob Lam, Benjamin Rodriguez, Mark Phillips, Nastaran Daneshgar, Ho-Jin Koh, Alice Koh, Jamaine Davis, Nina Devine, Saleem Muhammod, Estevão Scudese, Kenneth Arnold, Valeria Vanessa Chavarin, Ryan Daniel Robinson, Moumita Chakraborty, Jennifer Gaddy, Mariya Sweetwyne, Genesis Wilson, Elma Zaganjor, James Kezos, Cristiana Dondi, Anilkumar Reddy, Brian Glancy, Annet Kirabo, Anita Quintana, Dao-Fu Dai, Karen Ocorr, Sandra Murray, Steven Damo, Vernat Exil, Blake Riggs, Bret Mobley, Jose Gomez, Melanie McReynolds, Antentor Hinton, Jr., Aging Cell on p. e14009

A Caenorhabditis elegans model of adenylosuccinate lyase deficiency reveals neuromuscular and reproductive phenotypes of distinct etiology

Adam R. Fenton, Haley N. Janowitz, Latisha P. Franklin, Riley G. Young, Corinna A. Moro, Michael V. DeGennaro, Melanie R. McReynolds, Wenqing Wang, Wendy Hanna-Rose, 2023, Biochemical Medicine and Metabolic Biology

Juneteenth in STEMM and the barriers to equitable science

Alfred Mays, Angela Byars-Winston, Antentor Hinton, Andrea G. Marshall, Annet Kirabo, Avery August, Bianca J. Marlin, Blake Riggs, Blanton Tolbert, Celestine Wanjalla, Chad Womack, Chantell S. Evans, Christopher Barnes, Chrystal Starbird, Clintoria Williams, Corey Reynolds, Cornelius Taabazuing, Craig E. Cameron, Debra D. Murray, Derek Applewhite, Derrick J. Morton, Dexter Lee, Dionna W. Williams, Donald Lynch, Donita Brady, Erin Lynch, Florentine U.N. Rutaganira, Gustavo M. Silva, Haysetta Shuler, Ishmail Abdus Saboor, Jamaine Davis, Kafui Dzirasa, Latanya Hammonds-Odie, Loretta Reyes, Mariya T. Sweetwyne, Melanie R. McReynolds, Michael D.L. Johnson, Nathan A. Smith, Nikea Pittman, Olujimi A. Ajijola, Quinton Smith, Renã A.S. Robinson, Samantha C. Lewis, Sandra A. Murray, Sherilynn Black, Sonya E. Neal, Stanley Andrisse, Steven Townsend, Steven M. Damo, Theanne N. Griffith, W. Marcus Lambert, William M. Clemons, 2023, Cell on p. 2510-2517

NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis

Didem Ilter, Stanislav Drapela, Tanya Schild, Nathan P. Ward, Emma Adhikari, Vivien Low, John Asara, Thordur Oskarsson, Eric K. Lau, Gina M. DeNicola, Melanie R. McReynolds, Ana P. Gomes, 2023, Redox Biology

Three-dimensional mitochondria reconstructions of murine cardiac muscle changes in size across aging

Zer Vue, Kit Neikirk, Larry Vang, Edgar Garza-Lopez, Trace Christensen, Jianqiang Shao, Jacob Lam, Heather Beasley, Andrea Marshall, Amber Crabtree, Josephs Anudokem, Benjamin Rodriguez, Benjamin Kirk, Serif Bacevac, Taylor Barongan, Bryanna Shao, Dominique Stephens, Kinuthia Kabugi, Ho-Jin Koh, Alice Koh, Chantell Evans, Brittany Taylor, Anilkumar Reddy, Tyne Miller-Fleming, Ky’Era Actkins, Elma Zaganjor, Nastaran Daneshgar, Sandra Murray, Bret Mobley, Steven Damo, Jennifer Gaddy, Blake Riggs, Celestine Wanjalla, Annet Kirabo, Melanie McReynolds, Jose Gomez, Mark Phillips, Vernat Exil, Dao-Fu Dai, Antentor Hinton, 2023, American Journal of Physiology-Heart and Circulatory Physiology on p. H965-H982

A Minimal Kynurenine Pathway Was Preserved for Rhodoquinone but Not for De Novo NAD<sup>+</sup> Biosynthesis in Parasitic Worms: The Essential Role of NAD<sup>+</sup> Rescue Pathways

Rosina Comas-Ghierra, Abdulkareem Alshaheeb, Melanie R. McReynolds, Jennifer N. Shepherd, Gustavo Salinas, 2023, Antioxidants and Redox Signaling

Toying with reductive stress

Alexandria Murphy, Melanie McReynolds, 2023, Nature Chemical Biology

Acidic Methanol Treatment Facilitates Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry Imaging of Energy Metabolism

Wenyun Lu, Noel Park, Tara TeSlaa, Connor Jankowski, Laith Samarah, Melanie McReynolds, Xi Xing, Jessica Schembri, Morgan Woolf, Joshua Rabinowitz, Shawn Davidson, 2023, Analytical Chemistry on p. 14879-14888

Using mass spectrometry imaging to visualize age-related subcellular disruption

Kelly A. Hogan, Julianna D. Zeidler, Heather K. Beasley, Abrar I. Alsaadi, Abdulkareem A. Alshaheeb, Yi Chin Chang, Hua Tian, Antentor O. Hinton, Melanie R. McReynolds, 2023, Frontiers in Molecular Biosciences

Most-Cited Papers

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

Paras S. Minhas, Amira Latif-Hernandez, Melanie R. McReynolds, Aarooran S. Durairaj, Qian Wang, Amanda Rubin, Amit U. Joshi, Joy Q. He, Esha Gauba, Ling Liu, Congcong Wang, Miles Linde, Yuki Sugiura, Peter K. Moon, Ravi Majeti, Makoto Suematsu, Daria Mochly-Rosen, Irving L. Weissman, Frank M. Longo, Joshua D. Rabinowitz, Katrin I. Andreasson, 2021, Nature on p. 122-128

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD<sup>+</sup> and NMN levels

Claudia C.S. Chini, Thais R. Peclat, Gina M. Warner, Sonu Kashyap, Jair Machado Espindola-Netto, Guilherme C. de Oliveira, Lilian S. Gomez, Kelly A. Hogan, Mariana G. Tarragó, Amrutesh S. Puranik, Guillermo Agorrody, Katie L. Thompson, Kevin Dang, Starlynn Clarke, Bennett G. Childs, Karina S. Kanamori, Micaela A. Witte, Paola Vidal, Anna L. Kirkland, Marco De Cecco, Karthikeyani Chellappa, Melanie R. McReynolds, Connor Jankowski, Tamara Tchkonia, James L. Kirkland, John M. Sedivy, Jan M. van Deursen, Darren J. Baker, Wim van Schooten, Joshua D. Rabinowitz, Joseph A. Baur, Eduardo N. Chini, 2020, Nature Metabolism on p. 1284-1304

SLC25A51 is a mammalian mitochondrial NAD<sup>+</sup> transporter

Timothy S. Luongo, Jared M. Eller, Mu Jie Lu, Marc Niere, Fabio Raith, Caroline Perry, Marc R. Bornstein, Paul Oliphint, Lin Wang, Melanie R. McReynolds, Marie E. Migaud, Joshua D. Rabinowitz, F. Brad Johnson, Kai Johnsson, Mathias Ziegler, Xiaolu A. Cambronne, Joseph A. Baur, 2020, Nature on p. 174-179

Serine Catabolism Feeds NADH when Respiration Is Impaired

Lifeng Yang, Juan Carlos Garcia Canaveras, Zihong Chen, Lin Wang, Lingfan Liang, Cholsoon Jang, Johannes A. Mayr, Zhaoyue Zhang, Jonathan M. Ghergurovich, Le Zhan, Shilpy Joshi, Zhixian Hu, Melanie R. McReynolds, Xiaoyang Su, Eileen White, Raphael J. Morscher, Joshua D. Rabinowitz, 2020, Cell Metabolism on p. 809-821.e6

Acoustofluidic Rotational Manipulation of Cells and Organisms Using Oscillating Solid Structures

Adem Ozcelik, Nitesh Nama, Po-Hsun Huang, Murat Kaynak, Melanie McReynolds, Wendy Hanna-Rose, Tony Huang, 2016, Small on p. 5120-5125

Metabolite discovery through global annotation of untargeted metabolomics data

Li Chen, Wenyun Lu, Lin Wang, Xi Xing, Ziyang Chen, Xin Teng, Xianfeng Zeng, Antonio D. Muscarella, Yihui Shen, Alexis Cowan, Melanie R. McReynolds, Brandon J. Kennedy, Ashley M. Lato, Shawn R. Campagna, Mona Singh, Joshua D. Rabinowitz, 2021, Nature Methods on p. 1377-1385

Age-related NAD<sup>+</sup> decline

Melanie R. McReynolds, Karthikeyani Chellappa, Joseph A. Baur, 2020, Experimental Gerontology

Cell size is a determinant of stem cell potential during aging

Jette Lengefeld, Chia Wei Cheng, Pema Maretich, Marguerite Blair, Hannah Hagen, Melanie R. McReynolds, Emily Sullivan, Kyra Majors, Christina Roberts, Joon Ho Kang, Joachim D. Steiner, Teemu P. Miettinen, Scott R. Manalis, Adam Antebi, Sean J. Morrison, Jacqueline A. Lees, Laurie A. Boyer, Ömer H. Yilmaz, Angelika Amon, 2021, Science advances

Patching the Leaks: Revitalizing and Reimagining the STEM Pipeline

Antentor O. Hinton, Christina M. Termini, Elsie C. Spencer, Florentine U.N. Rutaganira, Daphney Chery, Re Ana Roby, Zer Vue, Angela D. Pack, Lillian J. Brady, Edgar Garza-Lopez, Andrea G. Marshall, Samantha C. Lewis, Haysetta D. Shuler, Brittany L. Taylor, Melanie R. McReynolds, Caroline B. Palavicino-Maggio, 2020, Cell on p. 568-575

Spatially resolved isotope tracing reveals tissue metabolic activity

Lin Wang, Xi Xing, Xianfeng Zeng, S. Ra Elle Jackson, Tara TeSlaa, Osama Al-Dalahmah, Laith Z. Samarah, Katharine Goodwin, Lifeng Yang, Melanie R. McReynolds, Xiaoxuan Li, Jeremy J. Wolff, Joshua D. Rabinowitz, Shawn M. Davidson, 2022, Nature Methods on p. 223-230