Melanie McReynolds

Huck Early Career Chair in Biochemistry and Molecular Biology; Assistant Professor of Biochemistry and Molecular Biology

Melanie McReynolds

Research Summary

The biochemistry behind aging and its intersection with stress, with the long-term goal of identifying strategies that promote healthier aging.

Huck Graduate Students

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Nad Glass Metabolic Pharmacological Metabolism Glucose Brain Mass Spectrometry Isotopes Metabolite Respiration Isotope Citric Acid Cycle Cognitive Dysfunction Nadp Ketogenic Diet Transducers Cell Size Pipeline Metabolomics Nicotinamide Mononucleotide Lipid Enzymes Kidney Neoplasm Metastasis Serine

Most Recent Publications

A guide to establishing, implementing, and optimizing diversity, equity, inclusion, and accessibility (DEIA) committees

Maigen Bethea, Sophielle Silvers, Latisha Franklin, Renã A.S. Robinson, Lillian J. Brady, Neng Vue, Heather K. Beasley, Annet Kirabo, Celestine N. Wanjalla, Haysetta D. Shuler, Antentor Hinton, Melanie R. McReynolds, 2024, American Journal of Physiology on p. H786-H796

Running a successful STEMM summer program: A week-by-week guide

Heather K. Beasley, Zer Vue, Melanie R. McReynolds, Edgar Garza-Lopez, Kit Neikirk, Margaret Mungai, Andrea G. Marshall, Bryanna Shao, Jazmine I. Benjamin, Celestine N. Wanjalla, Clintoria R. Williams, Sandra A. Murray, Valerie K. Jordan, Haysetta D. Shuler, Annet Kirabo, Antentor Hinton, 2024, Journal of Cellular Physiology

Mitochondria in disease: changes in shapes and dynamics

Brenita C. Jenkins, Kit Neikirk, Prasanna Katti, Steven M. Claypool, Annet Kirabo, Melanie R. McReynolds, Antentor Hinton, 2024, Trends in Biochemical Sciences

Speaking up for the invisible minority: First-generation students in higher education

Vijayvardhan Kamalumpundi, Sophielle Silvers, Latisha Franklin, Kit Neikirk, Elsie Spencer, Heather K. Beasley, Celestine N. Wanajalla, Zer Vue, Amber Crabtree, Annet Kirabo, Jennifer A. Gaddy, Steven M. Damo, Melanie R. McReynolds, Latanya H. Odie, Sandra A. Murray, Maria E. Zavala, Arnaldo D. Vazquez, Antentor Hinton, 2024, Journal of Cellular Physiology

3D reconstruction of murine mitochondria reveals changes in structure during aging linked to the MICOS complex

Zer Vue, Edgar Garza-Lopez, Kit Neikirk, Prasanna Katti, Larry Vang, Heather Beasley, Jianqiang Shao, Andrea G. Marshall, Amber Crabtree, Alexandria C. Murphy, Brenita C. Jenkins, Praveena Prasad, Chantell Evans, Brittany Taylor, Margaret Mungai, Mason Killion, Dominique Stephens, Trace A. Christensen, Jacob Lam, Benjamin Rodriguez, Mark A. Phillips, Nastaran Daneshgar, Ho Jin Koh, Alice Koh, Jamaine Davis, Nina Devine, Mohammad Saleem, Estevão Scudese, Kenneth Ryan Arnold, Valeria Vanessa Chavarin, Ryan Daniel Robinson, Moumita Chakraborty, Jennifer A. Gaddy, Mariya T. Sweetwyne, Genesis Wilson, Elma Zaganjor, James Kezos, Cristiana Dondi, Anilkumar K. Reddy, Brian Glancy, Annet Kirabo, Anita M. Quintana, Dao Fu Dai, Karen Ocorr, Sandra A. Murray, Steven M. Damo, Vernat Exil, Blake Riggs, Bret C. Mobley, Jose A. Gomez, Melanie R. McReynolds, Antentor Hinton, 2023, Aging Cell

A Caenorhabditis elegans model of adenylosuccinate lyase deficiency reveals neuromuscular and reproductive phenotypes of distinct etiology

A Fenton, H Janowitz, L Franklin, R Young, C Moro, M DeGennaro, Melanie R. McReynolds, W Wang, Wendy Hanna-Rose, 2023, Biochemical Medicine and Metabolic Biology on p. 107686

Three-dimensional mitochondria reconstructions of murine cardiac muscle changes in size across aging

Zer Vue, Kit Neikirk, Larry Vang, Edgar Garza-Lopez, Trace A. Christensen, Jianqiang Shao, Jacob Lam, Heather K. Beasley, Andrea G. Marshall, Amber Crabtree, Josephs Anudokem, Benjamin Rodriguez, Benjamin Kirk, Serif Bacevac, Taylor Barongan, Bryanna Shao, Dominique C. Stephens, Kinuthia Kabugi, Ho Jin Koh, Alice Koh, Chantell S. Evans, Brittany Taylor, Anilkumar K. Reddy, Tyne Miller-Fleming, Ky'Era V. Actkins, Elma Zaganjor, Nastaran Daneshgar, Sandra A. Murray, Bret C. Mobley, Steven M. Damo, Jennifer A. Gaddy, Blake Riggs, Celestine Wanjalla, Annet Kirabo, Melanie McReynolds, Jose A. Gomez, Mark A. Phillips, Vernat Exil, Dao Fu Dai, Antentor Hinton, 2023, American Journal of Physiology on p. H965-H982

Acidic Methanol Treatment Facilitates Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry Imaging of Energy Metabolism

Wenyun Lu, Noel R. Park, Tara TeSlaa, Connor S.R. Jankowski, Laith Samarah, Melanie McReynolds, Xi Xing, Jessica Schembri, Morgan T. Woolf, Joshua D. Rabinowitz, Shawn M. Davidson, 2023, Analytical Chemistry on p. 14879-14888

Juneteenth in STEMM and the barriers to equitable science

Alfred Mays, Angela Byars-Winston, Antentor Hinton, Andrea G. Marshall, Annet Kirabo, Avery August, Bianca J. Marlin, Blake Riggs, Blanton Tolbert, Celestine Wanjalla, Chad Womack, Chantell S. Evans, Christopher Barnes, Chrystal Starbird, Clintoria Williams, Corey Reynolds, Cornelius Taabazuing, Craig E. Cameron, Debra D. Murray, Derek Applewhite, Derrick J. Morton, Dexter Lee, Dionna W. Williams, Donald Lynch, Donita Brady, Erin Lynch, Florentine U.N. Rutaganira, Gustavo M. Silva, Haysetta Shuler, Ishmail Abdus Saboor, Jamaine Davis, Kafui Dzirasa, Latanya Hammonds-Odie, Loretta Reyes, Mariya T. Sweetwyne, Melanie R. McReynolds, Michael D.L. Johnson, Nathan A. Smith, Nikea Pittman, Olujimi A. Ajijola, Quinton Smith, Renã A.S. Robinson, Samantha C. Lewis, Sandra A. Murray, Sherilynn Black, Sonya E. Neal, Stanley Andrisse, Steven Townsend, Steven M. Damo, Theanne N. Griffith, W. Marcus Lambert, William M. Clemons, 2023, Cell on p. 2510-2517

NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis

Didem Ilter, Stanislav Drapela, Tanya Schild, Nathan P. Ward, Emma Adhikari, Vivien Low, John Asara, Thordur Oskarsson, Eric K. Lau, Gina M. DeNicola, Melanie R. McReynolds, Ana P. Gomes, 2023, Redox Biology

Most-Cited Papers

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

Paras S. Minhas, Amira Latif-Hernandez, Melanie R. McReynolds, Aarooran S. Durairaj, Qian Wang, Amanda Rubin, Amit U. Joshi, Joy Q. He, Esha Gauba, Ling Liu, Congcong Wang, Miles Linde, Yuki Sugiura, Peter K. Moon, Ravi Majeti, Makoto Suematsu, Daria Mochly-Rosen, Irving L. Weissman, Frank M. Longo, Joshua D. Rabinowitz, Katrin I. Andreasson, 2021, Nature on p. 122-128

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD<sup>+</sup> and NMN levels

Claudia C.S. Chini, Thais R. Peclat, Gina M. Warner, Sonu Kashyap, Jair Machado Espindola-Netto, Guilherme C. de Oliveira, Lilian S. Gomez, Kelly A. Hogan, Mariana G. Tarragó, Amrutesh S. Puranik, Guillermo Agorrody, Katie L. Thompson, Kevin Dang, Starlynn Clarke, Bennett G. Childs, Karina S. Kanamori, Micaela A. Witte, Paola Vidal, Anna L. Kirkland, Marco De Cecco, Karthikeyani Chellappa, Melanie R. McReynolds, Connor Jankowski, Tamara Tchkonia, James L. Kirkland, John M. Sedivy, Jan M. van Deursen, Darren J. Baker, Wim van Schooten, Joshua D. Rabinowitz, Joseph A. Baur, Eduardo N. Chini, 2020, Nature Metabolism on p. 1284-1304

SLC25A51 is a mammalian mitochondrial NAD<sup>+</sup> transporter

Timothy S. Luongo, Jared M. Eller, Mu Jie Lu, Marc Niere, Fabio Raith, Caroline Perry, Marc R. Bornstein, Paul Oliphint, Lin Wang, Melanie R. McReynolds, Marie E. Migaud, Joshua D. Rabinowitz, F. Brad Johnson, Kai Johnsson, Mathias Ziegler, Xiaolu A. Cambronne, Joseph A. Baur, 2020, Nature on p. 174-179

Serine Catabolism Feeds NADH when Respiration Is Impaired

Lifeng Yang, Juan Carlos Garcia Canaveras, Zihong Chen, Lin Wang, Lingfan Liang, Cholsoon Jang, Johannes A. Mayr, Zhaoyue Zhang, Jonathan M. Ghergurovich, Le Zhan, Shilpy Joshi, Zhixian Hu, Melanie R. McReynolds, Xiaoyang Su, Eileen White, Raphael J. Morscher, Joshua D. Rabinowitz, 2020, Cell Metabolism on p. 809-821.e6

Acoustofluidic Rotational Manipulation of Cells and Organisms Using Oscillating Solid Structures

Adem Ozcelik, Nitesh Nama, Po-Hsun Huang, Murat Kaynak, Melanie McReynolds, Wendy Hanna-Rose, Tony Huang, 2016, Small on p. 5120-5125

Metabolite discovery through global annotation of untargeted metabolomics data

Li Chen, Wenyun Lu, Lin Wang, Xi Xing, Ziyang Chen, Xin Teng, Xianfeng Zeng, Antonio D. Muscarella, Yihui Shen, Alexis Cowan, Melanie R. McReynolds, Brandon J. Kennedy, Ashley M. Lato, Shawn R. Campagna, Mona Singh, Joshua D. Rabinowitz, 2021, Nature Methods on p. 1377-1385

Age-related NAD<sup>+</sup> decline

Melanie R. McReynolds, Karthikeyani Chellappa, Joseph A. Baur, 2020, Experimental Gerontology

Cell size is a determinant of stem cell potential during aging

Jette Lengefeld, Chia Wei Cheng, Pema Maretich, Marguerite Blair, Hannah Hagen, Melanie R. McReynolds, Emily Sullivan, Kyra Majors, Christina Roberts, Joon Ho Kang, Joachim D. Steiner, Teemu P. Miettinen, Scott R. Manalis, Adam Antebi, Sean J. Morrison, Jacqueline A. Lees, Laurie A. Boyer, Ömer H. Yilmaz, Angelika Amon, 2021, Science advances

Spatially resolved isotope tracing reveals tissue metabolic activity

Lin Wang, Xi Xing, Xianfeng Zeng, S. Ra Elle Jackson, Tara TeSlaa, Osama Al-Dalahmah, Laith Z. Samarah, Katharine Goodwin, Lifeng Yang, Melanie R. McReynolds, Xiaoxuan Li, Jeremy J. Wolff, Joshua D. Rabinowitz, Shawn M. Davidson, 2022, Nature Methods on p. 223-230

Patching the Leaks: Revitalizing and Reimagining the STEM Pipeline

Antentor O. Hinton, Christina M. Termini, Elsie C. Spencer, Florentine U.N. Rutaganira, Daphney Chery, Re Ana Roby, Zer Vue, Angela D. Pack, Lillian J. Brady, Edgar Garza-Lopez, Andrea G. Marshall, Samantha C. Lewis, Haysetta D. Shuler, Brittany L. Taylor, Melanie R. McReynolds, Caroline B. Palavicino-Maggio, 2020, Cell on p. 568-575