Melanie McReynolds

Huck Early Career Chair in Biochemistry and Molecular Biology; Assistant Professor of Biochemistry and Molecular Biology

Melanie McReynolds

Research Summary

The biochemistry behind aging and its intersection with stress, with the long-term goal of identifying strategies that promote healthier aging.

Huck Graduate Students

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Nad Pharmacological Metabolism Metabolomics Mass Spectrometry Metabolic Glass Isotopes Metabolite Isotope Cell Size Lipopolysaccharides Tandem Mass Spectrometry Stem Cells Monocytes Glucose Genes Inflammation Brain Hematopoietic Stem Cells Liquid Nicotinamide Respiration Metabolism Enzymes Kidney

Most Recent Publications

NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis

Didem Ilter, Stanislav Drapela, Tanya Schild, Nathan P. Ward, Emma Adhikari, Vivien Low, John Asara, Thordur Oskarsson, Eric K. Lau, Gina M. DeNicola, Melanie R. McReynolds, Ana P. Gomes, 2023, Redox Biology

NAD precursors cycle between host tissues and the gut microbiome

Karthikeyani Chellappa, Melanie R. McReynolds, Wenyun Lu, Xianfeng Zeng, Mikhail Makarov, Faisal Hayat, Sarmistha Mukherjee, Yashaswini R. Bhat, Siddharth R. Lingala, Rafaella T. Shima, Hélène C. Descamps, Timothy Cox, Lixin Ji, Connor Jankowski, Qingwei Chu, Shawn M. Davidson, Christoph A. Thaiss, Marie E. Migaud, Joshua D. Rabinowitz, Joseph A. Baur, 2022, Cell Metabolism on p. 1947-1959.e5

mTOR regulation of metabolism limits LPS-induced monocyte inflammatory and procoagulant responses

Nina C. Lund, Yetunde Kayode, Melanie R. McReynolds, Deanna C. Clemmer, Hannah Hudson, Isabelle Clerc, Hee Kyung Hong, Jason M. Brenchley, Joseph Bass, Richard T. D’Aquila, Harry E. Taylor, 2022, Communications Biology

NAD<sup>+</sup> Flux and Resiliency in Aged Mice

Melanie R. McReynolds, 2022, FASEB Journal

Spatially resolved isotope tracing reveals tissue metabolic activity

Lin Wang, Xi Xing, Xianfeng Zeng, S. Ra Elle Jackson, Tara TeSlaa, Osama Al-Dalahmah, Laith Z. Samarah, Katharine Goodwin, Lifeng Yang, Melanie R. McReynolds, Xiaoxuan Li, Jeremy J. Wolff, Joshua D. Rabinowitz, Shawn M. Davidson, 2022, Nature Methods on p. 223-230

Combining Metabolomics and Experimental Evolution Reveals Key Mechanisms Underlying Longevity Differences in Laboratory Evolved Drosophila melanogaster Populations

Mark A. Phillips, Kenneth R. Arnold, Zer Vue, Heather K. Beasley, Edgar Garza-Lopez, Andrea G. Marshall, Derrick J. Morton, Melanie R. McReynolds, Thomas T. Barter, Antentor Hinton, 2022, International Journal of Molecular Sciences

Using virtual interviewing to create a more accessible hybrid academic job market

Christina M. Termini, Florentine U.N. Rutaganira, Caroline B. Palavicino-Maggio, Chelsey C. Spriggs, Chantell S. Evans, Melanie R. McReynolds, 2021, Cell on p. 6217-6221

NAD<sup>+</sup> flux is maintained in aged mice despite lower tissue concentrations

Melanie R. McReynolds, Karthikeyani Chellappa, Eric Chiles, Connor Jankowski, Yihui Shen, Li Chen, Hélène C. Descamps, Sarmistha Mukherjee, Yashaswini R. Bhat, Siddharth R. Lingala, Qingwei Chu, Paul Botolin, Faisal Hayat, Tomohito Doke, Katalin Susztak, Christoph A. Thaiss, Wenyun Lu, Marie E. Migaud, Xiaoyang Su, Joshua D. Rabinowitz, Joseph A. Baur, 2021, Cell Systems on p. 1160-1172.e4

Metabolite discovery through global annotation of untargeted metabolomics data

Li Chen, Wenyun Lu, Lin Wang, Xi Xing, Ziyang Chen, Xin Teng, Xianfeng Zeng, Antonio D. Muscarella, Yihui Shen, Alexis Cowan, Melanie R. McReynolds, Brandon J. Kennedy, Ashley M. Lato, Shawn R. Campagna, Mona Singh, Joshua D. Rabinowitz, 2021, Nature Methods on p. 1377-1385

Cell size is a determinant of stem cell potential during aging

Jette Lengefeld, Chia Wei Cheng, Pema Maretich, Marguerite Blair, Hannah Hagen, Melanie R. McReynolds, Emily Sullivan, Kyra Majors, Christina Roberts, Joon Ho Kang, Joachim D. Steiner, Teemu P. Miettinen, Scott R. Manalis, Adam Antebi, Sean J. Morrison, Jacqueline A. Lees, Laurie A. Boyer, Ömer H. Yilmaz, Angelika Amon, 2021, Science advances

Most-Cited Papers

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

Paras S. Minhas, Amira Latif-Hernandez, Melanie R. McReynolds, Aarooran S. Durairaj, Qian Wang, Amanda Rubin, Amit U. Joshi, Joy Q. He, Esha Gauba, Ling Liu, Congcong Wang, Miles Linde, Yuki Sugiura, Peter K. Moon, Ravi Majeti, Makoto Suematsu, Daria Mochly-Rosen, Irving L. Weissman, Frank M. Longo, Joshua D. Rabinowitz, Katrin I. Andreasson, 2021, Nature on p. 122-128

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD<sup>+</sup> and NMN levels

Claudia C.S. Chini, Thais R. Peclat, Gina M. Warner, Sonu Kashyap, Jair Machado Espindola-Netto, Guilherme C. de Oliveira, Lilian S. Gomez, Kelly A. Hogan, Mariana G. Tarragó, Amrutesh S. Puranik, Guillermo Agorrody, Katie L. Thompson, Kevin Dang, Starlynn Clarke, Bennett G. Childs, Karina S. Kanamori, Micaela A. Witte, Paola Vidal, Anna L. Kirkland, Marco De Cecco, Karthikeyani Chellappa, Melanie R. McReynolds, Connor Jankowski, Tamara Tchkonia, James L. Kirkland, John M. Sedivy, Jan M. van Deursen, Darren J. Baker, Wim van Schooten, Joshua D. Rabinowitz, Joseph A. Baur, Eduardo N. Chini, 2020, Nature Metabolism on p. 1284-1304

SLC25A51 is a mammalian mitochondrial NAD<sup>+</sup> transporter

Timothy S. Luongo, Jared M. Eller, Mu Jie Lu, Marc Niere, Fabio Raith, Caroline Perry, Marc R. Bornstein, Paul Oliphint, Lin Wang, Melanie R. McReynolds, Marie E. Migaud, Joshua D. Rabinowitz, F. Brad Johnson, Kai Johnsson, Mathias Ziegler, Xiaolu A. Cambronne, Joseph A. Baur, 2020, Nature on p. 174-179

Serine Catabolism Feeds NADH when Respiration Is Impaired

Lifeng Yang, Juan Carlos Garcia Canaveras, Zihong Chen, Lin Wang, Lingfan Liang, Cholsoon Jang, Johannes A. Mayr, Zhaoyue Zhang, Jonathan M. Ghergurovich, Le Zhan, Shilpy Joshi, Zhixian Hu, Melanie R. McReynolds, Xiaoyang Su, Eileen White, Raphael J. Morscher, Joshua D. Rabinowitz, 2020, Cell Metabolism on p. 809-821.e6

Acoustofluidic Rotational Manipulation of Cells and Organisms Using Oscillating Solid Structures

Adem Ozcelik, Nitesh Nama, Po-Hsun Huang, Murat Kaynak, Melanie McReynolds, Wendy Hanna-Rose, Tony Huang, 2016, Small on p. 5120-5125

Age-related NAD<sup>+</sup> decline

Melanie R. McReynolds, Karthikeyani Chellappa, Joseph A. Baur, 2020, Experimental Gerontology

Metabolite discovery through global annotation of untargeted metabolomics data

Li Chen, Wenyun Lu, Lin Wang, Xi Xing, Ziyang Chen, Xin Teng, Xianfeng Zeng, Antonio D. Muscarella, Yihui Shen, Alexis Cowan, Melanie R. McReynolds, Brandon J. Kennedy, Ashley M. Lato, Shawn R. Campagna, Mona Singh, Joshua D. Rabinowitz, 2021, Nature Methods on p. 1377-1385

Cell size is a determinant of stem cell potential during aging

Jette Lengefeld, Chia Wei Cheng, Pema Maretich, Marguerite Blair, Hannah Hagen, Melanie R. McReynolds, Emily Sullivan, Kyra Majors, Christina Roberts, Joon Ho Kang, Joachim D. Steiner, Teemu P. Miettinen, Scott R. Manalis, Adam Antebi, Sean J. Morrison, Jacqueline A. Lees, Laurie A. Boyer, Ömer H. Yilmaz, Angelika Amon, 2021, Science advances

Patching the Leaks: Revitalizing and Reimagining the STEM Pipeline

Antentor O. Hinton, Christina M. Termini, Elsie C. Spencer, Florentine U.N. Rutaganira, Daphney Chery, Re Ana Roby, Zer Vue, Angela D. Pack, Lillian J. Brady, Edgar Garza-Lopez, Andrea G. Marshall, Samantha C. Lewis, Haysetta D. Shuler, Brittany L. Taylor, Melanie R. McReynolds, Caroline B. Palavicino-Maggio, 2020, Cell on p. 568-575

NAD<sup>+</sup> flux is maintained in aged mice despite lower tissue concentrations

Melanie R. McReynolds, Karthikeyani Chellappa, Eric Chiles, Connor Jankowski, Yihui Shen, Li Chen, Hélène C. Descamps, Sarmistha Mukherjee, Yashaswini R. Bhat, Siddharth R. Lingala, Qingwei Chu, Paul Botolin, Faisal Hayat, Tomohito Doke, Katalin Susztak, Christoph A. Thaiss, Wenyun Lu, Marie E. Migaud, Xiaoyang Su, Joshua D. Rabinowitz, Joseph A. Baur, 2021, Cell Systems on p. 1160-1172.e4