Melanie McReynolds
Huck Early Career Chair in Biochemistry and Molecular Biology; Assistant Professor of Biochemistry and Molecular Biology

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119 Huck Life Sciences
University Park, PA - She/Her
- mrm45@psu.edu
- 814-865-0919
Research Summary
The biochemistry behind aging and its intersection with stress, with the long-term goal of identifying strategies that promote healthier aging.
Huck Graduate Students
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- Center for Cellular Dynamics
- Integrative and Biomedical Physiology
Links
Publication Tags
These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.
Nad Pharmacological Metabolism Metabolomics Mass Spectrometry Metabolic Glass Isotopes Metabolite Isotope Cell Size Lipopolysaccharides Tandem Mass Spectrometry Stem Cells Monocytes Glucose Genes Inflammation Brain Hematopoietic Stem Cells Liquid Nicotinamide Respiration Metabolism Enzymes KidneyMost Recent Publications
NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis
Didem Ilter, Stanislav Drapela, Tanya Schild, Nathan P. Ward, Emma Adhikari, Vivien Low, John Asara, Thordur Oskarsson, Eric K. Lau, Gina M. DeNicola, Melanie R. McReynolds, Ana P. Gomes, 2023, Redox Biology
NAD precursors cycle between host tissues and the gut microbiome
Karthikeyani Chellappa, Melanie R. McReynolds, Wenyun Lu, Xianfeng Zeng, Mikhail Makarov, Faisal Hayat, Sarmistha Mukherjee, Yashaswini R. Bhat, Siddharth R. Lingala, Rafaella T. Shima, Hélène C. Descamps, Timothy Cox, Lixin Ji, Connor Jankowski, Qingwei Chu, Shawn M. Davidson, Christoph A. Thaiss, Marie E. Migaud, Joshua D. Rabinowitz, Joseph A. Baur, 2022, Cell Metabolism on p. 1947-1959.e5
mTOR regulation of metabolism limits LPS-induced monocyte inflammatory and procoagulant responses
Nina C. Lund, Yetunde Kayode, Melanie R. McReynolds, Deanna C. Clemmer, Hannah Hudson, Isabelle Clerc, Hee Kyung Hong, Jason M. Brenchley, Joseph Bass, Richard T. D’Aquila, Harry E. Taylor, 2022, Communications Biology
NAD<sup>+</sup> Flux and Resiliency in Aged Mice
Melanie R. McReynolds, 2022, FASEB Journal
Spatially resolved isotope tracing reveals tissue metabolic activity
Lin Wang, Xi Xing, Xianfeng Zeng, S. Ra Elle Jackson, Tara TeSlaa, Osama Al-Dalahmah, Laith Z. Samarah, Katharine Goodwin, Lifeng Yang, Melanie R. McReynolds, Xiaoxuan Li, Jeremy J. Wolff, Joshua D. Rabinowitz, Shawn M. Davidson, 2022, Nature Methods on p. 223-230
Combining Metabolomics and Experimental Evolution Reveals Key Mechanisms Underlying Longevity Differences in Laboratory Evolved Drosophila melanogaster Populations
Mark A. Phillips, Kenneth R. Arnold, Zer Vue, Heather K. Beasley, Edgar Garza-Lopez, Andrea G. Marshall, Derrick J. Morton, Melanie R. McReynolds, Thomas T. Barter, Antentor Hinton, 2022, International Journal of Molecular Sciences
Using virtual interviewing to create a more accessible hybrid academic job market
Christina M. Termini, Florentine U.N. Rutaganira, Caroline B. Palavicino-Maggio, Chelsey C. Spriggs, Chantell S. Evans, Melanie R. McReynolds, 2021, Cell on p. 6217-6221
NAD<sup>+</sup> flux is maintained in aged mice despite lower tissue concentrations
Melanie R. McReynolds, Karthikeyani Chellappa, Eric Chiles, Connor Jankowski, Yihui Shen, Li Chen, Hélène C. Descamps, Sarmistha Mukherjee, Yashaswini R. Bhat, Siddharth R. Lingala, Qingwei Chu, Paul Botolin, Faisal Hayat, Tomohito Doke, Katalin Susztak, Christoph A. Thaiss, Wenyun Lu, Marie E. Migaud, Xiaoyang Su, Joshua D. Rabinowitz, Joseph A. Baur, 2021, Cell Systems on p. 1160-1172.e4
Metabolite discovery through global annotation of untargeted metabolomics data
Li Chen, Wenyun Lu, Lin Wang, Xi Xing, Ziyang Chen, Xin Teng, Xianfeng Zeng, Antonio D. Muscarella, Yihui Shen, Alexis Cowan, Melanie R. McReynolds, Brandon J. Kennedy, Ashley M. Lato, Shawn R. Campagna, Mona Singh, Joshua D. Rabinowitz, 2021, Nature Methods on p. 1377-1385
Cell size is a determinant of stem cell potential during aging
Jette Lengefeld, Chia Wei Cheng, Pema Maretich, Marguerite Blair, Hannah Hagen, Melanie R. McReynolds, Emily Sullivan, Kyra Majors, Christina Roberts, Joon Ho Kang, Joachim D. Steiner, Teemu P. Miettinen, Scott R. Manalis, Adam Antebi, Sean J. Morrison, Jacqueline A. Lees, Laurie A. Boyer, Ömer H. Yilmaz, Angelika Amon, 2021, Science advances
Most-Cited Papers
Restoring metabolism of myeloid cells reverses cognitive decline in ageing
Paras S. Minhas, Amira Latif-Hernandez, Melanie R. McReynolds, Aarooran S. Durairaj, Qian Wang, Amanda Rubin, Amit U. Joshi, Joy Q. He, Esha Gauba, Ling Liu, Congcong Wang, Miles Linde, Yuki Sugiura, Peter K. Moon, Ravi Majeti, Makoto Suematsu, Daria Mochly-Rosen, Irving L. Weissman, Frank M. Longo, Joshua D. Rabinowitz, Katrin I. Andreasson, 2021, Nature on p. 122-128
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD<sup>+</sup> and NMN levels
Claudia C.S. Chini, Thais R. Peclat, Gina M. Warner, Sonu Kashyap, Jair Machado Espindola-Netto, Guilherme C. de Oliveira, Lilian S. Gomez, Kelly A. Hogan, Mariana G. Tarragó, Amrutesh S. Puranik, Guillermo Agorrody, Katie L. Thompson, Kevin Dang, Starlynn Clarke, Bennett G. Childs, Karina S. Kanamori, Micaela A. Witte, Paola Vidal, Anna L. Kirkland, Marco De Cecco, Karthikeyani Chellappa, Melanie R. McReynolds, Connor Jankowski, Tamara Tchkonia, James L. Kirkland, John M. Sedivy, Jan M. van Deursen, Darren J. Baker, Wim van Schooten, Joshua D. Rabinowitz, Joseph A. Baur, Eduardo N. Chini, 2020, Nature Metabolism on p. 1284-1304
SLC25A51 is a mammalian mitochondrial NAD<sup>+</sup> transporter
Timothy S. Luongo, Jared M. Eller, Mu Jie Lu, Marc Niere, Fabio Raith, Caroline Perry, Marc R. Bornstein, Paul Oliphint, Lin Wang, Melanie R. McReynolds, Marie E. Migaud, Joshua D. Rabinowitz, F. Brad Johnson, Kai Johnsson, Mathias Ziegler, Xiaolu A. Cambronne, Joseph A. Baur, 2020, Nature on p. 174-179
Serine Catabolism Feeds NADH when Respiration Is Impaired
Lifeng Yang, Juan Carlos Garcia Canaveras, Zihong Chen, Lin Wang, Lingfan Liang, Cholsoon Jang, Johannes A. Mayr, Zhaoyue Zhang, Jonathan M. Ghergurovich, Le Zhan, Shilpy Joshi, Zhixian Hu, Melanie R. McReynolds, Xiaoyang Su, Eileen White, Raphael J. Morscher, Joshua D. Rabinowitz, 2020, Cell Metabolism on p. 809-821.e6
Acoustofluidic Rotational Manipulation of Cells and Organisms Using Oscillating Solid Structures
Adem Ozcelik, Nitesh Nama, Po-Hsun Huang, Murat Kaynak, Melanie McReynolds, Wendy Hanna-Rose, Tony Huang, 2016, Small on p. 5120-5125
Age-related NAD<sup>+</sup> decline
Melanie R. McReynolds, Karthikeyani Chellappa, Joseph A. Baur, 2020, Experimental Gerontology
Metabolite discovery through global annotation of untargeted metabolomics data
Li Chen, Wenyun Lu, Lin Wang, Xi Xing, Ziyang Chen, Xin Teng, Xianfeng Zeng, Antonio D. Muscarella, Yihui Shen, Alexis Cowan, Melanie R. McReynolds, Brandon J. Kennedy, Ashley M. Lato, Shawn R. Campagna, Mona Singh, Joshua D. Rabinowitz, 2021, Nature Methods on p. 1377-1385
Cell size is a determinant of stem cell potential during aging
Jette Lengefeld, Chia Wei Cheng, Pema Maretich, Marguerite Blair, Hannah Hagen, Melanie R. McReynolds, Emily Sullivan, Kyra Majors, Christina Roberts, Joon Ho Kang, Joachim D. Steiner, Teemu P. Miettinen, Scott R. Manalis, Adam Antebi, Sean J. Morrison, Jacqueline A. Lees, Laurie A. Boyer, Ömer H. Yilmaz, Angelika Amon, 2021, Science advances
Patching the Leaks: Revitalizing and Reimagining the STEM Pipeline
Antentor O. Hinton, Christina M. Termini, Elsie C. Spencer, Florentine U.N. Rutaganira, Daphney Chery, Re Ana Roby, Zer Vue, Angela D. Pack, Lillian J. Brady, Edgar Garza-Lopez, Andrea G. Marshall, Samantha C. Lewis, Haysetta D. Shuler, Brittany L. Taylor, Melanie R. McReynolds, Caroline B. Palavicino-Maggio, 2020, Cell on p. 568-575
NAD<sup>+</sup> flux is maintained in aged mice despite lower tissue concentrations
Melanie R. McReynolds, Karthikeyani Chellappa, Eric Chiles, Connor Jankowski, Yihui Shen, Li Chen, Hélène C. Descamps, Sarmistha Mukherjee, Yashaswini R. Bhat, Siddharth R. Lingala, Qingwei Chu, Paul Botolin, Faisal Hayat, Tomohito Doke, Katalin Susztak, Christoph A. Thaiss, Wenyun Lu, Marie E. Migaud, Xiaoyang Su, Joshua D. Rabinowitz, Joseph A. Baur, 2021, Cell Systems on p. 1160-1172.e4