Melanie McReynolds

Huck Early Career Chair in Biochemistry and Molecular Biology; Assistant Professor of Biochemistry and Molecular Biology

Melanie McReynolds

Research Summary

The biochemistry behind aging and its intersection with stress, with the long-term goal of identifying strategies that promote healthier aging.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Nad Metabolomics Mass Spectrometry Pharmacological Metabolism Metabolite Isotopes Isotope Metabolic Cell Size Mathematics Tandem Mass Spectrometry Lipopolysaccharides Stem Cells Technology Monocytes Glucose Genes Inflammation Brain Hematopoietic Stem Cells Nicotinamide Liquid Respiration Metabolism Enzymes

Most Recent Publications

Karthikeyani Chellappa, Melanie R. McReynolds, Wenyun Lu, Xianfeng Zeng, Mikhail Makarov, Faisal Hayat, Sarmistha Mukherjee, Yashaswini R. Bhat, Siddharth R. Lingala, Rafaella T. Shima, Hélène C. Descamps, Timothy Cox, Lixin Ji, Connor Jankowski, Qingwei Chu, Shawn M. Davidson, Christoph A. Thaiss, Marie E. Migaud, Joshua D. Rabinowitz, Joseph A. Baur, 2022, Cell Metabolism on p. 1947-1959.e5

Nina C. Lund, Yetunde Kayode, Melanie R. McReynolds, Deanna C. Clemmer, Hannah Hudson, Isabelle Clerc, Hee Kyung Hong, Jason M. Brenchley, Joseph Bass, Richard T. D’Aquila, Harry E. Taylor, 2022, Communications Biology

NAD<sup>+</sup> Flux and Resiliency in Aged Mice

Melanie R. McReynolds, 2022, FASEB Journal

Spatially resolved isotope tracing reveals tissue metabolic activity

Lin Wang, Xi Xing, Xianfeng Zeng, S. Ra Elle Jackson, Tara TeSlaa, Osama Al-Dalahmah, Laith Z. Samarah, Katharine Goodwin, Lifeng Yang, Melanie R. McReynolds, Xiaoxuan Li, Jeremy J. Wolff, Joshua D. Rabinowitz, Shawn M. Davidson, 2022, Nature Methods on p. 223-230

Mark A. Phillips, Kenneth R. Arnold, Zer Vue, Heather K. Beasley, Edgar Garza-Lopez, Andrea G. Marshall, Derrick J. Morton, Melanie R. McReynolds, Thomas T. Barter, Antentor Hinton, 2022, International Journal of Molecular Sciences

Christina M. Termini, Florentine U.N. Rutaganira, Caroline B. Palavicino-Maggio, Chelsey C. Spriggs, Chantell S. Evans, Melanie R. McReynolds, 2021, Cell on p. 6217-6221

Melanie R. McReynolds, Karthikeyani Chellappa, Eric Chiles, Connor Jankowski, Yihui Shen, Li Chen, Hélène C. Descamps, Sarmistha Mukherjee, Yashaswini R. Bhat, Siddharth R. Lingala, Qingwei Chu, Paul Botolin, Faisal Hayat, Tomohito Doke, Katalin Susztak, Christoph A. Thaiss, Wenyun Lu, Marie E. Migaud, Xiaoyang Su, Joshua D. Rabinowitz, Joseph A. Baur, 2021, Cell Systems on p. 1160-1172.e4

Jette Lengefeld, Chia Wei Cheng, Pema Maretich, Marguerite Blair, Hannah Hagen, Melanie R. McReynolds, Emily Sullivan, Kyra Majors, Christina Roberts, Joon Ho Kang, Joachim D. Steiner, Teemu P. Miettinen, Scott R. Manalis, Adam Antebi, Sean J. Morrison, Jacqueline A. Lees, Laurie A. Boyer, Ömer H. Yilmaz, Angelika Amon, 2021, Science advances

Li Chen, Wenyun Lu, Lin Wang, Xi Xing, Ziyang Chen, Xin Teng, Xianfeng Zeng, Antonio D. Muscarella, Yihui Shen, Alexis Cowan, Melanie R. McReynolds, Brandon J. Kennedy, Ashley M. Lato, Shawn R. Campagna, Mona Singh, Joshua D. Rabinowitz, 2021, Nature Methods on p. 1377-1385

Andrea Marshall, Angela D. Pack, Sarah Afua Owusu, Rainbo Hultman, David Drake, Florentine U.N. Rutaganira, Maria Namwanje, Chantell S. Evans, Edgar Garza-Lopez, Samantha C. Lewis, Christina M. Termini, Salma AshShareef, Innes Hicsasmaz, Brittany Taylor, Melanie R. McReynolds, Haysetta Shuler, Antentor O. Hinton, 2021, FEMS Immunology and Medical Microbiology

Most-Cited Papers

Paras S. Minhas, Amira Latif-Hernandez, Melanie R. McReynolds, Aarooran S. Durairaj, Qian Wang, Amanda Rubin, Amit U. Joshi, Joy Q. He, Esha Gauba, Ling Liu, Congcong Wang, Miles Linde, Yuki Sugiura, Peter K. Moon, Ravi Majeti, Makoto Suematsu, Daria Mochly-Rosen, Irving L. Weissman, Frank M. Longo, Joshua D. Rabinowitz, Katrin I. Andreasson, 2021, Nature on p. 122-128

Claudia C.S. Chini, Thais R. Peclat, Gina M. Warner, Sonu Kashyap, Jair Machado Espindola-Netto, Guilherme C. de Oliveira, Lilian S. Gomez, Kelly A. Hogan, Mariana G. Tarragó, Amrutesh S. Puranik, Guillermo Agorrody, Katie L. Thompson, Kevin Dang, Starlynn Clarke, Bennett G. Childs, Karina S. Kanamori, Micaela A. Witte, Paola Vidal, Anna L. Kirkland, Marco De Cecco, Karthikeyani Chellappa, Melanie R. McReynolds, Connor Jankowski, Tamara Tchkonia, James L. Kirkland, John M. Sedivy, Jan M. van Deursen, Darren J. Baker, Wim van Schooten, Joshua D. Rabinowitz, Joseph A. Baur, Eduardo N. Chini, 2020, Nature Metabolism on p. 1284-1304

Timothy S. Luongo, Jared M. Eller, Mu Jie Lu, Marc Niere, Fabio Raith, Caroline Perry, Marc R. Bornstein, Paul Oliphint, Lin Wang, Melanie R. McReynolds, Marie E. Migaud, Joshua D. Rabinowitz, F. Brad Johnson, Kai Johnsson, Mathias Ziegler, Xiaolu A. Cambronne, Joseph A. Baur, 2020, Nature on p. 174-179

Lifeng Yang, Juan Carlos Garcia Canaveras, Zihong Chen, Lin Wang, Lingfan Liang, Cholsoon Jang, Johannes A. Mayr, Zhaoyue Zhang, Jonathan M. Ghergurovich, Le Zhan, Shilpy Joshi, Zhixian Hu, Melanie R. McReynolds, Xiaoyang Su, Eileen White, Raphael J. Morscher, Joshua D. Rabinowitz, 2020, Cell Metabolism on p. 809-821.e6

Melanie R. McReynolds, Karthikeyani Chellappa, Joseph A. Baur, 2020, Experimental Gerontology

Antentor O. Hinton, Christina M. Termini, Elsie C. Spencer, Florentine U.N. Rutaganira, Daphney Chery, Re Ana Roby, Zer Vue, Angela D. Pack, Lillian J. Brady, Edgar Garza-Lopez, Andrea G. Marshall, Samantha C. Lewis, Haysetta D. Shuler, Brittany L. Taylor, Melanie R. McReynolds, Caroline B. Palavicino-Maggio, 2020, Cell on p. 568-575

Li Chen, Wenyun Lu, Lin Wang, Xi Xing, Ziyang Chen, Xin Teng, Xianfeng Zeng, Antonio D. Muscarella, Yihui Shen, Alexis Cowan, Melanie R. McReynolds, Brandon J. Kennedy, Ashley M. Lato, Shawn R. Campagna, Mona Singh, Joshua D. Rabinowitz, 2021, Nature Methods on p. 1377-1385

Jette Lengefeld, Chia Wei Cheng, Pema Maretich, Marguerite Blair, Hannah Hagen, Melanie R. McReynolds, Emily Sullivan, Kyra Majors, Christina Roberts, Joon Ho Kang, Joachim D. Steiner, Teemu P. Miettinen, Scott R. Manalis, Adam Antebi, Sean J. Morrison, Jacqueline A. Lees, Laurie A. Boyer, Ömer H. Yilmaz, Angelika Amon, 2021, Science advances

Antentor O. Hinton, Zer Vue, Christina M. Termini, Brittany L. Taylor, Haysetta D. Shuler, Melanie R. McReynolds, 2020, EMBO Reports

Melanie R. McReynolds, Christina M. Termini, Antentor O. Hinton, Brittany L. Taylor, Zer Vue, Sunny C. Huang, Re Anna S. Roby, Haysetta Shuler, Calvin S. Carter, 2020, Nature Biotechnology on p. 1477-1482