Melanie McReynolds

Huck Early Career Chair in Biochemistry and Molecular Biology; Assistant Professor of Biochemistry and Molecular Biology

Melanie McReynolds

Research Summary

The biochemistry behind aging and its intersection with stress, with the long-term goal of identifying strategies that promote healthier aging.

Huck Graduate Students

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Nad Glass Glucose Brain Metabolite Mass Spectrometry Isotopes Respiration Isotope Nicotinamide Mononucleotide Enzymes Citric Acid Cycle Pipeline Myeloid Cells Metabolic Acoustics Cell Size Metabolomics Microchannels Kidney Mathematics Cognitive Dysfunction Mesencephalon Technology Serine

Most Recent Publications

A review of undergraduate research programs aimed at underrepresented students

Heather K. Beasley, Zer Vue, Melanie R. McReynolds, Kit Neikirk, Edgar Garza-Lopez, Margaret Mungai, Andrea G. Marshall, Bryanna Shao, Jazmine Benjamin, Celestine N. Wanjalla, Clintoria R. Williams, Sandra A. Murray, Haysetta D. Shuler, Annet Kirabo, Antentor Hinton, 2024, STAR Protocols

TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models

Edward N. Wilson, Congcong Wang, Michelle S. Swarovski, Kristy A. Zera, Hannah E. Ennerfelt, Qian Wang, Aisling Chaney, Esha Gauba, Javier A. Ramos Benitez, Yann Le Guen, Paras S. Minhas, Maharshi Panchal, Yuting J. Tan, Eran Blacher, Chinyere A. Iweka, Haley Cropper, Poorva Jain, Qingkun Liu, Swapnil S. Mehta, Abigail J. Zuckerman, Matthew Xin, Jacob Umans, Jolie Huang, Aarooran S. Durairaj, Geidy E. Serrano, Thomas G. Beach, Michael D. Greicius, Michelle L. James, Marion S. Buckwalter, Melanie R. McReynolds, Joshua D. Rabinowitz, Katrin I. Andreasson, 2024, Nature Neuroscience on p. 873-885

Mitochondria in disease: changes in shapes and dynamics

Brenita C. Jenkins, Kit Neikirk, Prasanna Katti, Steven M. Claypool, Annet Kirabo, Melanie R. McReynolds, Antentor Hinton, 2024, Trends in Biochemical Sciences on p. 346-360

A guide to establishing, implementing, and optimizing diversity, equity, inclusion, and accessibility (DEIA) committees

Maigen Bethea, Sophielle Silvers, Latisha Franklin, Renã A.S. Robinson, Lillian J. Brady, Neng Vue, Heather K. Beasley, Annet Kirabo, Celestine N. Wanjalla, Haysetta D. Shuler, Antentor Hinton, Melanie R. McReynolds, 2024, American Journal of Physiology on p. H786-H796

The graduate school guide: How to prepare for the qualifying exam and assemble a thesis/graduate committee

Crystal D. Rogers, Annet Kirabo, Melanie McReynolds, Mariya T. Sweetwyne, Celestine Wanjalla, Jazmine Benjamin, Edith M. Williams, Jennifer A. Gaddy, Clintoria R. Williams, Steven M. Damo, Sandra A. Murray, Antentor Hinton, 2024, Journal of Cellular Physiology

Speaking up for the invisible minority: First-generation students in higher education

Vijayvardhan Kamalumpundi, Sophielle Silvers, Latisha Franklin, Kit Neikirk, Elsie Spencer, Heather K. Beasley, Celestine N. Wanajalla, Zer Vue, Amber Crabtree, Annet Kirabo, Jennifer A. Gaddy, Steven M. Damo, Melanie R. McReynolds, Latanya H. Odie, Sandra A. Murray, Maria E. Zavala, Arnaldo D. Vazquez, Antentor Hinton, 2024, Journal of Cellular Physiology

Running a successful STEMM summer program: A week-by-week guide

Heather K. Beasley, Zer Vue, Melanie R. McReynolds, Edgar Garza-Lopez, Kit Neikirk, Margaret Mungai, Andrea G. Marshall, Bryanna Shao, Jazmine I. Benjamin, Celestine N. Wanjalla, Clintoria R. Williams, Sandra A. Murray, Valerie K. Jordan, Haysetta D. Shuler, Annet Kirabo, Antentor Hinton, 2024, Journal of Cellular Physiology

Ablation of Sam50 is associated with fragmentation and alterations in metabolism in murine and human myotubes

Bryanna Shao, Mason Killion, Ashton Oliver, Chia Vang, Faben Zeleke, Kit Neikirk, Zer Vue, Edgar Garza-Lopez, Jian qiang Shao, Margaret Mungai, Jacob Lam, Qiana Williams, Christopher T. Altamura, Aaron Whiteside, Kinuthia Kabugi, Jessica McKenzie, Maria Ezedimma, Han Le, Alice Koh, Estevão Scudese, Larry Vang, Andrea G. Marshall, Amber Crabtree, Janelle I. Tanghal, Dominique Stephens, Ho Jin Koh, Brenita C. Jenkins, Sandra A. Murray, Anthonya T. Cooper, Clintoria Williams, Steven M. Damo, Melanie R. McReynolds, Jennifer A. Gaddy, Celestine N. Wanjalla, Heather K. Beasley, Antentor Hinton, 2024, Journal of Cellular Physiology

3D reconstruction of murine mitochondria reveals changes in structure during aging linked to the MICOS complex

Zer Vue, Edgar Garza-Lopez, Kit Neikirk, Prasanna Katti, Larry Vang, Heather Beasley, Jianqiang Shao, Andrea G. Marshall, Amber Crabtree, Alexandria C. Murphy, Brenita C. Jenkins, Praveena Prasad, Chantell Evans, Brittany Taylor, Margaret Mungai, Mason Killion, Dominique Stephens, Trace A. Christensen, Jacob Lam, Benjamin Rodriguez, Mark A. Phillips, Nastaran Daneshgar, Ho Jin Koh, Alice Koh, Jamaine Davis, Nina Devine, Mohammad Saleem, Estevão Scudese, Kenneth Ryan Arnold, Valeria Vanessa Chavarin, Ryan Daniel Robinson, Moumita Chakraborty, Jennifer A. Gaddy, Mariya T. Sweetwyne, Genesis Wilson, Elma Zaganjor, James Kezos, Cristiana Dondi, Anilkumar K. Reddy, Brian Glancy, Annet Kirabo, Anita M. Quintana, Dao Fu Dai, Karen Ocorr, Sandra A. Murray, Steven M. Damo, Vernat Exil, Blake Riggs, Bret C. Mobley, Jose A. Gomez, Melanie R. McReynolds, Antentor Hinton, 2023, Aging Cell

A Caenorhabditis elegans model of adenylosuccinate lyase deficiency reveals neuromuscular and reproductive phenotypes of distinct etiology

A Fenton, H Janowitz, L Franklin, R Young, C Moro, M DeGennaro, Melanie R. McReynolds, W Wang, Wendy Hanna-Rose, 2023, Biochemical Medicine and Metabolic Biology on p. 107686

Most-Cited Papers

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

Paras S. Minhas, Amira Latif-Hernandez, Melanie R. McReynolds, Aarooran S. Durairaj, Qian Wang, Amanda Rubin, Amit U. Joshi, Joy Q. He, Esha Gauba, Ling Liu, Congcong Wang, Miles Linde, Yuki Sugiura, Peter K. Moon, Ravi Majeti, Makoto Suematsu, Daria Mochly-Rosen, Irving L. Weissman, Frank M. Longo, Joshua D. Rabinowitz, Katrin I. Andreasson, 2021, Nature on p. 122-128

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD<sup>+</sup> and NMN levels

Claudia C.S. Chini, Thais R. Peclat, Gina M. Warner, Sonu Kashyap, Jair Machado Espindola-Netto, Guilherme C. de Oliveira, Lilian S. Gomez, Kelly A. Hogan, Mariana G. Tarragó, Amrutesh S. Puranik, Guillermo Agorrody, Katie L. Thompson, Kevin Dang, Starlynn Clarke, Bennett G. Childs, Karina S. Kanamori, Micaela A. Witte, Paola Vidal, Anna L. Kirkland, Marco De Cecco, Karthikeyani Chellappa, Melanie R. McReynolds, Connor Jankowski, Tamara Tchkonia, James L. Kirkland, John M. Sedivy, Jan M. van Deursen, Darren J. Baker, Wim van Schooten, Joshua D. Rabinowitz, Joseph A. Baur, Eduardo N. Chini, 2020, Nature Metabolism on p. 1284-1304

SLC25A51 is a mammalian mitochondrial NAD<sup>+</sup> transporter

Timothy S. Luongo, Jared M. Eller, Mu Jie Lu, Marc Niere, Fabio Raith, Caroline Perry, Marc R. Bornstein, Paul Oliphint, Lin Wang, Melanie R. McReynolds, Marie E. Migaud, Joshua D. Rabinowitz, F. Brad Johnson, Kai Johnsson, Mathias Ziegler, Xiaolu A. Cambronne, Joseph A. Baur, 2020, Nature on p. 174-179

Serine Catabolism Feeds NADH when Respiration Is Impaired

Lifeng Yang, Juan Carlos Garcia Canaveras, Zihong Chen, Lin Wang, Lingfan Liang, Cholsoon Jang, Johannes A. Mayr, Zhaoyue Zhang, Jonathan M. Ghergurovich, Le Zhan, Shilpy Joshi, Zhixian Hu, Melanie R. McReynolds, Xiaoyang Su, Eileen White, Raphael J. Morscher, Joshua D. Rabinowitz, 2020, Cell Metabolism on p. 809-821.e6

Metabolite discovery through global annotation of untargeted metabolomics data

Li Chen, Wenyun Lu, Lin Wang, Xi Xing, Ziyang Chen, Xin Teng, Xianfeng Zeng, Antonio D. Muscarella, Yihui Shen, Alexis Cowan, Melanie R. McReynolds, Brandon J. Kennedy, Ashley M. Lato, Shawn R. Campagna, Mona Singh, Joshua D. Rabinowitz, 2021, Nature Methods on p. 1377-1385

Acoustofluidic Rotational Manipulation of Cells and Organisms Using Oscillating Solid Structures

Adem Ozcelik, Nitesh Nama, Po-Hsun Huang, Murat Kaynak, Melanie McReynolds, Wendy Hanna-Rose, Tony Huang, 2016, Small on p. 5120-5125

Age-related NAD<sup>+</sup> decline

Melanie R. McReynolds, Karthikeyani Chellappa, Joseph A. Baur, 2020, Experimental Gerontology

Spatially resolved isotope tracing reveals tissue metabolic activity

Lin Wang, Xi Xing, Xianfeng Zeng, S. Ra Elle Jackson, Tara TeSlaa, Osama Al-Dalahmah, Laith Z. Samarah, Katharine Goodwin, Lifeng Yang, Melanie R. McReynolds, Xiaoxuan Li, Jeremy J. Wolff, Joshua D. Rabinowitz, Shawn M. Davidson, 2022, Nature Methods on p. 223-230

Cell size is a determinant of stem cell potential during aging

Jette Lengefeld, Chia Wei Cheng, Pema Maretich, Marguerite Blair, Hannah Hagen, Melanie R. McReynolds, Emily Sullivan, Kyra Majors, Christina Roberts, Joon Ho Kang, Joachim D. Steiner, Teemu P. Miettinen, Scott R. Manalis, Adam Antebi, Sean J. Morrison, Jacqueline A. Lees, Laurie A. Boyer, Ömer H. Yilmaz, Angelika Amon, 2021, Science advances

Patching the Leaks: Revitalizing and Reimagining the STEM Pipeline

Antentor O. Hinton, Christina M. Termini, Elsie C. Spencer, Florentine U.N. Rutaganira, Daphney Chery, Re Ana Roby, Zer Vue, Angela D. Pack, Lillian J. Brady, Edgar Garza-Lopez, Andrea G. Marshall, Samantha C. Lewis, Haysetta D. Shuler, Brittany L. Taylor, Melanie R. McReynolds, Caroline B. Palavicino-Maggio, 2020, Cell on p. 568-575