Gary Perdew

Director of the Center for Molecular Toxicology and Carcinogenesis; H. Thomas and Dorothy Willits Hallowell Chair in Agricultural Sciences

Gary Perdew

Research Summary

Mechanisms of receptor-mediated carcinogenesis.

Huck Affiliations

Links

Publication Tags

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Aryl Hydrocarbon Receptors Ligands Hydrocarbon Microbiota Toxicity Human Ahr Protein Homeostasis Hydrocarbons Dioxins Pharmacological Metabolism Liver Ligand Metabolic Gene Expression Gastrointestinal Microbiome Tryptophan Neoplasms Chemical Activation Keratinocytes Indole Xenobiotics Diet Aryl Hydrocarbon Receptor Antagonist Metabolomics Pharmaceutical Preparations

Most Recent Publications

Xenobiotic Receptor-Mediated Toxicity

GH Perdew, IA Murray, JM Peters,

Effects of the environmental mammary carcinogen 6-nitrochrysene on p53 and p21Cip1 protein expression and cell cycle regulation in MCF-7 and MCF-10A cells

Y. Sun, C. Herzog, J. Krzeminski, S. Amin, Gary Perdew, Chem. Biol. Interaction

Third generation quinoline-3-carboxamide transcriptional disrupter of HDAC4, HIF-1α, and MEF-2 signaling for metastatic castration-resistant prostate cancer

John T. Isaacs, Susan L. Dalrymple, Lizamma Antony, David Marc Rosen, Ilsa M. Coleman, Peter S. Nelson, Maya Kostova, Iain A. Murray, Gary H. Perdew, Samuel R. Denmeade, Emmanuel S. Akinboye, W. Nathaniel Brennen, 2023, Prostate on p. 1470-1493

Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites

Dhwani Patel, Iain A. Murray, Fangcong Dong, Andrew J. Annalora, Krishne Gowda, Denise M. Coslo, Jacek Krzeminski, Imhoi Koo, Fuhua Hao, Shantu G. Amin, Craig B. Marcus, Andrew D. Patterson, Gary H. Perdew, 2023, Metabolites

Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways

A Ganapathy, K Saha, A Wang, P Arumugam, V Dharmaprakash, Gregory Yochum, Walter Koltun, M Nighot, Gary H. Perdew, T Thompson, Thomas Ma, Prashant Nighot, 2023, Cell Reports on p. 112705

Complex chemical signals dictate Ah receptor activation through the gut-lung axis

Fangcong Dong, Iain A. Murray, Andrew Annalora, Denise M. Coslo, Dhimant Desai, Krishne Gowda, Jian Yang, Dingbowen Wang, Imhoi Koo, Fuhua Hao, Shantu G. Amin, Andrew D. Patterson, Craig Marcus, Gary H. Perdew, 2023, FASEB Journal on p. e23010

Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)

Xiaoling Chen, Andrew D. Patterson, Gary H. Perdew, Iain A. Murray, Joshua J. Kellogg, 2023, Journal of Functional Foods

The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022

Gary H. Perdew, Charlotte Esser, Megan Snyder, David H. Sherr, Ellen H. van den Bogaard, Karen McGovern, Pedro M. Fernández-Salguero, Xavier Coumoul, Andrew D. Patterson, 2023, International Journal of Molecular Sciences

Aryl hydrocarbon receptor activation affects nitrergic neuronal survival and delays intestinal motility in mice

Anitha Vijay, Nina R. Boyle, Supriya M. Kumar, Gary H. Perdew, Shanthi Srinivasan, Andrew D. Patterson, 2023, Toxicological Sciences on p. 117-128

Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming

Xiaoliang Zhou, Debopriya Chakraborty, Iain A. Murray, Denise Coslo, Zoe Kehs, Anitha Vijay, Carolyn Ton, Dhimant Desai, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2023, Laboratory Investigation on p. 100012

Most-Cited Papers

Aryl hydrocarbon receptor ligands in cancer: Friend and foe

Iain A. Murray, Andrew D. Patterson, Gary H. Perdew, 2014, Nature Reviews Cancer on p. 801-814

Special section on drug metabolism and the microbiome - Minireview indole and tryptophan metabolism: Endogenous and dietary routes to ah receptor activation

Troy D. Hubbard, Iain A. Murray, Gary H. Perdew, 2015, Drug Metabolism and Disposition on p. 1522-1535

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Health Perspectives on p. 679-688

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific Reports

Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity

Fangcong Dong, Fuhua Hao, Iain A. Murray, Philip B. Smith, Imhoi Koo, Alyssa Tindall, Penny Kris-Etherton, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary Perdew, 2020, Gut Microbes on p. 1788899

Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation

Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Joost Schalkwijk, Gary H. Perdew, Adam B. Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328

Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice

Limin Zhang, Emmanuel Hatzakis, Robert G. Nichols, Ruixin Hao, Jared Correll, Philip B. Smith, Christopher R. Chiaro, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Science & Technology on p. 8067-8077

Mode of action and dose-response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study

R. A. Budinsky, D. Schrenk, T. Simon, M. Van Den Berg, J. F. Reichard, J. B. Silkworth, L. L. Aylward, A. Brix, T. Gasiewicz, N. Kaminski, G. Perdew, T. B. Starr, N. J. Walker, J. C. Rowlands, 2014, Critical Reviews in Toxicology on p. 83-119

Urolithin a is a dietary microbiota-derived human aryl hydrocarbon receptor antagonist

Gulsum E. Muku, Iain A. Murray, Juan C. Espín, Gary H. Perdew, 2018, Metabolites

Ligand activation of the Ah receptor contributes to gastrointestinal homeostasis

Iain A. Murray, Gary Perdew, 2017, Current Opinion in Toxicology on p. 15-23