Gary Perdew

Director of the Center for Molecular Toxicology and Carcinogenesis; H. Thomas and Dorothy Willits Hallowell Chair in Agricultural Sciences

Gary Perdew

Research Summary

Mechanisms of receptor-mediated carcinogenesis.

Huck Affiliations


Publication Tags

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Aryl Hydrocarbon Receptors Hydrocarbon Ligands Microbiota Metabolic Toxicity Ligand Hydrocarbons Human Ahr Protein Homeostasis Polychlorinated Biphenyls Pharmacological Metabolism Liver Skin Gastrointestinal Microbiome Dioxins Therapeutics Tryptophan Gene Expression Keratinocytes Metabolomics Neoplasms Xenobiotics Metabolite Chemical Activation

Most Recent Publications

Xenobiotic Receptor-Mediated Toxicity

GH Perdew, IA Murray, JM Peters,

Gary H. Perdew, Charlotte Esser, Megan Snyder, David H. Sherr, Ellen H. van den Bogaard, Karen McGovern, Pedro M. Fernández-Salguero, Xavier Coumoul, Andrew D. Patterson, 2023, International Journal of Molecular Sciences

Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming

Xiaoliang Zhou, Debopriya Chakraborty, Iain Alexander Murray, Denise Coslo, Zoe Kehs, Anitha Vijay, Carolyn Ton, Dhimant Desai, Shantu Amin, Andrew David Patterson, Gary H. Perdew, 2023, Laboratory Investigation on p. 100012

Gijs Rikken, Kayla J. Smith, Noa J.M. van den Brink, Jos P.H. Smits, Krishne Gowda, Angela Alnemri, Gulsum E. Kuzu, Iain Alexander Murray, Jyh ming Lin, Jos G.A. Smits, Ivonne M. van Vlijmen-Willems, Shantu G. Amin, Gary H. Perdew, Ellen H. van den Bogaard, 2023, Biochemical Pharmacology

J Granados, K Falah, Imhoi Koo, E Morgan, Gary H. Perdew, A Patterson, N Jamshidi, S Nigam, 2022, Scientific Reports on p. 16625

Yuan Tian, B Rimal, W Gui, Imhoi Koo, Shigetoshi Yokoyama, Gary H. Perdew, A Patterson, 2022, International Journal of Molecular Sciences

E Morgan, Gary H. Perdew, A Patterson, 2022, Toxicological Sciences on p. 189-213

Medha Priyadarshini, Guadalupe Navarro, Derek J. Reiman, Anukriti Sharma, Kai Xu, Kristen Lednovich, Christopher R. Manzella, Md Wasim Khan, Mariana Salas Garcia, Sarah Allard, Barton Wicksteed, George E. Chlipala, Barbara Szynal, Beatriz Penalver Bernabe, Pauline M. Maki, Ravinder K. Gill, Gary H. Perdew, Jack Gilbert, Yang Dai, Brian T. Layden, 2022, Gastroenterology on p. 1675-1689.e11

Most-Cited Papers

Iain A. Murray, Andrew D. Patterson, Gary H. Perdew, 2014, Nature Reviews Cancer on p. 801-814

Troy D. Hubbard, Iain A. Murray, Gary H. Perdew, 2015, Drug Metabolism and Disposition on p. 1522-1535

Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Health Perspectives on p. 679-688

Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific Reports

Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Joost Schalkwijk, Gary H. Perdew, Adam B. Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328

Fangcong Dong, Fuhua Hao, Iain A. Murray, Philip B. Smith, Imhoi Koo, Alyssa Tindall, Penny Kris-Etherton, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary Perdew, 2020, Gut Microbes on p. 1788899

Limin Zhang, Emmanuel Hatzakis, Robert G. Nichols, Ruixin Hao, Jared Correll, Philip B. Smith, Christopher R. Chiaro, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Science & Technology on p. 8067-8077

Mode of action and dose-response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study

R. A. Budinsky, D. Schrenk, T. Simon, M. Van Den Berg, J. F. Reichard, J. B. Silkworth, L. L. Aylward, A. Brix, T. Gasiewicz, N. Kaminski, G. Perdew, T. B. Starr, N. J. Walker, J. C. Rowlands, 2014, Critical Reviews in Toxicology on p. 83-119

Iain A. Murray, Gary Perdew, 2017, Current Opinion in Toxicology on p. 15-23

Gulsum E. Muku, Iain A. Murray, Juan C. Espín, Gary H. Perdew, 2018, Metabolites