Gary Perdew
Director of the Center for Molecular Toxicology and Carcinogenesis; H. Thomas and Dorothy Willits Hallowell Chair in Agricultural Sciences

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309 Huck Life Sciences
University Park, PA - ghp2@psu.edu
- 814-865-0400
Research Summary
Mechanisms of receptor-mediated carcinogenesis.
Huck Affiliations
- Integrative and Biomedical Physiology
- Molecular, Cellular, and Integrative Biosciences
- Center for Molecular Toxicology and Carcinogenesis
Links
Publication Tags
Aryl Hydrocarbon Receptors Ligands Hydrocarbon Microbiota Ligand Chemical Activation Hydrocarbons Liver Metabolic Pharmacological Metabolism Tryptophan Polychlorinated Biphenyls Skin Homeostasis Gastrointestinal Microbiome Dioxins Genes Toxicity Bacteria Metabolomics Metabolite Epithelial Cells Metabolites Human Ahr Protein NeoplasmsMost Recent Publications
Effects of the environmental mammary carcinogen 6-nitrochrysene on p53 and p21Cip1 protein expression and cell cycle regulation in MCF-7 and MCF-10A cells
Y. Sun, C. Herzog, J. Krzeminski, S. Amin, Gary Perdew, Chem. Biol. Interaction
AHR is a master regulator of diverse pathways in endogenous metabolism
Jeffry C. Granados, Kian Falah, Imhoi Koo, Ethan W. Morgan, Gary H. Perdew, Andrew David Patterson, Neema Jamshidi, Sanjay K. Nigam, 2022, Scientific Reports
Early Life Short-Term Exposure to Polychlorinated Biphenyl 126 in Mice Leads to Metabolic Dysfunction and Microbiota Changes in Adulthood
Yuan Tian, Bipin Rimal, Wei Gui, Imhoi Koo, Shigetoshi Yokoyama, Gary H. Perdew, Andrew D. Patterson, 2022, International Journal of Molecular Sciences
Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research
Ethan W. Morgan, Gary H. Perdew, Andrew D. Patterson, 2022, Toxicological Sciences on p. 189-213
Gestational Insulin Resistance Is Mediated by the Gut Microbiome–Indoleamine 2,3-Dioxygenase Axis
Medha Priyadarshini, Guadalupe Navarro, Derek J. Reiman, Anukriti Sharma, Kai Xu, Kristen Lednovich, Christopher R. Manzella, Md Wasim Khan, Mariana Salas Garcia, Sarah Allard, Barton Wicksteed, George E. Chlipala, Barbara Szynal, Beatriz Penalver Bernabe, Pauline M. Maki, Ravinder K. Gill, Gary H. Perdew, Jack Gilbert, Yang Dai, Brian T. Layden, 2022, Gastroenterology on p. 1675-1689.e11
The aryl hydrocarbon receptor at the forefront of host-microbe interactions in the skin: A perspective on current knowledge gaps and directions for future research and therapeutic applications
Ellen H. van den Bogaard, Charlotte Esser, Gary H. Perdew, 2021, Experimental Dermatology on p. 1477-1483
The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis
Qing Liu, Limin Zhang, Erik L. Allman, Troy D. Hubbard, Iain A. Murray, Fuhua Hao, Yuan Tian, Wei Gui, Robert G. Nichols, Philip B. Smith, Mallappa Anitha, Gary H. Perdew, Andrew D. Patterson, 2021, Toxicology
The Enigma of AHR Activation in the Skin: Interplay among Ligands, Metabolism, and Bioavailability
Ellen H. van den Bogaard, Gary H. Perdew, 2021, Journal of Investigative Dermatology on p. 1385-1388
How ah receptor ligand specificity became important in understanding its physiological function
Iain A. Murray, Gary H. Perdew, 2020, International Journal of Molecular Sciences on p. 1-19
β-Naphthoflavone activation of the Ah receptor alleviates irradiation-induced intestinal injury in mice
Xiaoliang Zhou, Deguan Li, Wenqing Xu, Heng Zhang, Hao Wang, Gary H. Perdew, 2020, Antioxidants on p. 1-14
Most-Cited Papers
Aryl hydrocarbon receptor ligands in cancer: Friend and foe
Iain A. Murray, Andrew D. Patterson, Gary H. Perdew, 2014, Nature Reviews Cancer on p. 801-814
Special section on drug metabolism and the microbiome - Minireview indole and tryptophan metabolism: Endogenous and dietary routes to ah receptor activation
Troy D. Hubbard, Iain A. Murray, Gary H. Perdew, 2015, Drug Metabolism and Disposition on p. 1522-1535
Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation
Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Health Perspectives on p. 679-688
Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles
Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific Reports
Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice
Limin Zhang, Emmanuel Hatzakis, Robert G. Nichols, Ruixin Hao, Jared Correll, Philip B. Smith, Christopher R. Chiaro, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Science & Technology on p. 8067-8077
Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation
Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Joost Schalkwijk, Gary H. Perdew, Adam B. Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328
Mode of action and dose-response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study
R. A. Budinsky, D. Schrenk, T. Simon, M. Van Den Berg, J. F. Reichard, J. B. Silkworth, L. L. Aylward, A. Brix, T. Gasiewicz, N. Kaminski, G. Perdew, T. B. Starr, N. J. Walker, J. C. Rowlands, 2014, Critical Reviews in Toxicology on p. 83-119
Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity
Fangcong Dong, Fuhua Hao, Iain A. Murray, Philip B. Smith, Imhoi Koo, Alyssa Tindall, Penny Kris-Etherton, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2020, Gut Microbes on p. 1788899
Ligand activation of the Ah receptor contributes to gastrointestinal homeostasis
Iain A. Murray, Gary H. Perdew, 2017, Current Opinion in Toxicology on p. 15-23
Divergent Ah Receptor Ligand Selectivity during Hominin Evolution
Troy D. Hubbard, Iain A. Murray, William H. Bisson, Alexis P. Sullivan, Aswathy Sebastian, George H. Perry, Nina G. Jablonski, Gary H. Perdew, 2016, Molecular Biology and Evolution on p. 2648-2658
News Articles Featuring Gary Perdew
Sep 02, 2022
Metabolomics Core Facility continues to expand while pushing scientific bounds
Established nearly a decade ago, Penn State’s Metabolomics Core Facility is housed in the Huck Institutes of the Life Sciences on the University Park campus.
Full Article
Mar 30, 2020
Examining Links Between AHR, Microbiome, and Immune Functions
Gary Perdew, Ph.D., studies how the aryl hydrocarbon receptor (AHR) pathway interacts with the microbiome, the immune system, and protective barriers in skin and the gut.
Full Article