Gary Perdew

Director of the Center for Molecular Toxicology and Carcinogenesis; John T. and Paige S. Smith Professor in Agricultural Sciences

Gary Perdew

Research Summary

Mechanisms of receptor-mediated carcinogenesis.

Huck Affiliations

Links

Publication Tags

Aryl Hydrocarbon Receptors Ligands Liver Chemical Activation Dioxins Hydrocarbons Polychlorinated Biphenyls Microbiota Gastrointestinal Microbiome Toxicity Genes Homeostasis Fatty Acids Gene Expression Tryptophan Xenobiotics Lipogenesis 2,3,7,8 Tetrachlorodibenzofuran Response Elements Cholesterol Epithelial Cells Environmental Pollutants Proteolysis Indole Metabolites

Most Recent Papers

Effects of the environmental mammary carcinogen 6-nitrochrysene on p53 and p21Cip1 protein expression and cell cycle regulation in MCF-7 and MCF-10A cells

Y. Sun, C. Herzog, J. Krzeminski, S. Amin, Gary Perdew, Chem. Biol. Interaction

How ah receptor ligand specificity became important in understanding its physiological function

Iain A. Murray, Gary H. Perdew, 2020, International Journal of Molecular Sciences on p. 1-19

β-Naphthoflavone activation of the Ah receptor alleviates irradiation-induced intestinal injury in mice

Xiaoliang Zhou, Deguan Li, Wenqing Xu, Heng Zhang, Hao Wang, Gary H. Perdew, 2020, Antioxidants on p. 1-14

Targeting the pregnane X receptor using microbial metabolite mimicry

Zdeněk Dvořák, Felix Kopp, Cait M. Costello, Jazmin S. Kemp, Hao Li, Aneta Vrzalová, Martina Štěpánková, Iveta Bartoňková, Eva Jiskrová, Karolína Poulíková, Barbora Vyhlídalová, Lars U. Nordstroem, Chamini V. Karunaratne, Harmit S. Ranhotra, Kyu Shik Mun, Anjaparavanda P. Naren, Iain A. Murray, Gary H. Perdew, Julius Brtko, Lucia Toporova, Arne Schön, William G. Wallace, William G. Walton, Matthew R. Redinbo, Katherine Sun, Amanda Beck, Sandhya Kortagere, Michelle C. Neary, Aneesh Chandran, Saraswathi Vishveshwara, Maria M. Cavalluzzi, Giovanni Lentini, Julia Yue Cui, Haiwei Gu, John C. March, Shirshendu Chatterjee, Adam Matson, Dennis Wright, Kyle L. Flannigan, Simon A. Hirota, Ryan Balfour Sartor, Sridhar Mani, 2020, EMBO Molecular Medicine

PCB126 blocks the thermogenic beiging response of adipocytes

Francoise A. Gourronc, Gary H. Perdew, Larry W. Robertson, Aloysius J. Klingelhutz, 2020, Environmental Science and Pollution Research on p. 8897-8904

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

Gulsum E. Muku, Ann Kusnadi, Guray Kuzu, Rachel Tanos, Iain A. Murray, Krishne Gowda, Shantu Amin, Gary H. Perdew, 2020, Laboratory Investigation on p. 250-264

Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran

Robert G. Nichols, Jingtao Zhang, Jingwei Cai, Iain A. Murray, Imhoi Koo, Philip B. Smith, Gary H. Perdew, Andrew D. Patterson, 2020, Metabolites

The aryl hydrocarbon receptor as a mediator of host-microbiota interplay

Fangcong Dong, Gary H. Perdew, 2020, Gut Microbes

Activation of the Ah Receptor Modulates Gastrointestinal Homeostasis and the Intestinal Microbiome

Gulsum E. Muku, Iain A. Murray, Gary H. Perdew, 2019, Current Pharmacology Reports on p. 319-331

Selective Ah receptor ligands mediate enhanced SREBP1 proteolysis to restrict lipogenesis in sebocytes.

Gulsum E. Muku, Nicholas Blazanin, Fangcong Dong, Philip B. Smith, Diane Thiboutot, Krishne Gowda, Shantu Amin, Iain A. Murray, Gary H. Perdew, 2019, Toxicological Sciences on p. 146-158

Most-Cited Papers

Aryl hydrocarbon receptor ligands in cancer

Iain A. Murray, Andrew D. Patterson, Gary H. Perdew, 2014, Nature Reviews Cancer on p. 801-814

Xenobiotic metabolism, disposition, and regulation by receptors

Curtis J. Omiecinski, John P. Vanden Heuvel, Gary H. Perdew, Jeffrey M. Peters, 2011, Toxicological Sciences on p. S49-S75

Special section on drug metabolism and the microbiome - Minireview indole and tryptophan metabolism

Troy D. Hubbard, Iain A. Murray, Gary H. Perdew, 2015, Drug Metabolism and Disposition on p. 1522-1535

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Health Perspectives on p. 679-688

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific Reports

Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism

Kayla J. Smith, Iain Alexander Murray, Rachel Tanos, John Tellew, Anthony E. Boitano, William H. Bisson, Siva K. Kolluri, Michael P. Cooke, Gary H. Perdew, 2011, Journal of Pharmacology and Experimental Therapeutics on p. 318-327

Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner

Rachel Tanos, Rushang D. Patel, Iain Alexander Murray, Philip B. Smith, Andrew David Patterson, Gary H. Perdew, 2012, Hepatology on p. 1994-2004

Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice

Limin Zhang, Emmanuel Hatzakis, Robert G. Nichols, Ruixin Hao, Jared Correll, Philip B. Smith, Christopher R. Chiaro, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Science & Technology on p. 8067-8077

Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver

Rachel Tanos, Iain A. Murray, Philip B. Smith, Andrew Patterson, Gary H. Perdew, 2012, Toxicological Sciences on p. 372-379

Mode of action and dose-response framework analysis for receptor-mediated toxicity

R. A. Budinsky, D. Schrenk, T. Simon, M. Van Den Berg, J. F. Reichard, J. B. Silkworth, L. L. Aylward, A. Brix, T. Gasiewicz, N. Kaminski, G. Perdew, T. B. Starr, N. J. Walker, J. C. Rowlands, 2014, Critical Reviews in Toxicology on p. 83-119