Gary Perdew

Director of the Center for Molecular Toxicology and Carcinogenesis; John T. and Paige S. Smith Professor in Agricultural Sciences

Gary Perdew

Research Summary

Mechanisms of receptor-mediated carcinogenesis.

Huck Affiliations

Links

Publication Tags

Aryl Hydrocarbon Receptors Ligands Human Ahr Protein Interleukin 6 Hydrocarbons Microbiota Indican Polychlorinated Biphenyls Dioxins Response Elements Anti Inflammatory Agents Chemical Activation Modulators Kynurenic Acid 2,8 Dihydroxyquinoline Genes Metabolism Sulfates Cytokines Cells Homeostasis Gene Expression Transcriptional Activation Assays Transcription

Most Recent Papers

Evolution of the human Ah receptor conferred desensitization to smoke-derived toxicants

Gary Perdew, Nina Jablonski, Molecular Biology and Evolution on p. 2648-58

RESEARCH PROJECT OUTLINE

Jeffrey Peters, Gary Perdew,

Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity.

F Dong, F Hao, Iain Murray, Philip Smith, I Koo, A Tindall, Penny Kris-Etherton, Krishnegowda Gowdahalli, Shantu Amin, Andrew Patterson, Gary Perdew, 2020, Gut microbes on p. 1-24

Metatranscriptomic Analysis of the Mouse Gut Microbiome Response to the Persistent Organic Pollutant 2,3,7,8-Tetrachlorodibenzofuran.

Renea Nichols, Jian Zhang, Jingjing Cai, Iain Murray, I Koo, Philip Smith, Gary Perdew, Andrew Patterson, 2019, Metabolites

Selective Ah receptor ligands mediate enhanced SREBP1 proteolysis to restrict lipogenesis in sebocytes.

G Muku, N Blazanin, F Dong, Philip Smith, Diane Thiboutot, Krishnegowda Gowdahalli, Shantu Amin, Iain Murray, Gary Perdew, 2019, Toxicological sciences : an official journal of the Society of Toxicology on p. 146-158

Isolation and identification of aryl hydrocarbon receptor modulators in white button mushrooms (Agaricus bisporus)

Yuan Tian, Wei Gui, Philip B. Smith, Imhoi Koo, Iain A. Murray, Margherita T. Cantorna, Gary H. Perdew, Andrew D. Patterson, 2019, Journal of agricultural and food chemistry on p. 9286-9294

Microbiota metabolism promotes synthesis of the human Ah receptor agonist 2,8-dihydroxyquinoline.

Troy D. Hubbard, Qing Liu, Iain A. Murray, Fangcong Dong, Charles Miller, Philip B. Smith, Krishne Gowda, Jyh Ming Lin, Shantu Amin, Andrew D. Patterson, Gary H. Perdew, 2019, Journal of Proteome Research on p. 1715-1724

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

Gulsum E. Muku, Ann Kusnadi, Guray Kuzu, Rachel Tanos, Iain Alexander Murray, Krishne Gowda, Shantu Amin, Gary H. Perdew, 2019, Laboratory Investigation

PCB126 blocks the thermogenic beiging response of adipocytes

Francoise A. Gourronc, Gary H. Perdew, Larry W. Robertson, Aloysius J. Klingelhutz, 2019, Environmental Science and Pollution Research

Urolithin a is a dietary microbiota-derived human aryl hydrocarbon receptor antagonist

Gulsum E. Muku, Iain A. Murray, Juan C. Espín, Gary H. Perdew, 2018, Metabolites

Most-Cited Papers

Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells

Anthony E. Boitano, Jian Wang, Russell Romeo, Laure C. Bouchez, Albert E. Parker, Sue E. Sutton, John R. Walker, Colin A. Flaveny, Gary H. Perdew, Michael S. Denison, Peter G. Schultz, Michael P. Cooke, 2010, Science on p. 1345-1348

Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling

Brett C. DiNatale, Iain A. Murray, Jennifer C. Schroeder, Colin A. Flaveny, Tejas S. Lahoti, Elizabeth M. Laurenzana, Curtis J. Omiecinski, Gary H. Perdew, 2010, Toxicological Sciences on p. 89-97

The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor

Jennifer C. Schroeder, Brett C. DiNatale, Iain A. Murray, Colin A. Flaveny, Qiang Liu, Elizabeth M. Laurenzana, Jyh Ming Lin, Stephen C. Strom, Curtis J. Omiecinski, Shantu Amin, Gary H. Perdew, 2010, Biochemistry on p. 393-400

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental health perspectives on p. 679-688

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific reports

Mechanistic insights into the events that lead to synergistic induction of interleukin 6 transcription upon activation of the aryl hydrocarbon receptor and inflammatory signaling

Brett C. DiNatale, Jennifer C. Schroeder, Lauren J. Francey, Ann Kusnadi, Gary H. Perdew, 2010, Journal of Biological Chemistry on p. 24388-24397

Evidence for ligand-mediated selective modulation of aryl hydrocarbon receptor activity

Iain A. Murray, Jose L. Morales, Colin A. Flaveny, Brett C. DiNatale, Chris Chiaro, Krishnegowda Gowdahalli, Shantu Amin, Gary H. Perdew, 2010, Molecular pharmacology on p. 247-254

Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties

Iain A. Murray, Gowdahalli Krishnegowda, Brett C. Dinatale, Colin Flaveny, Chris Chiaro, Jyh Ming Lin, Arun K. Sharma, Shantu Amin, Gary H. Perdew, 2010, Chemical research in toxicology on p. 955-966

Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism

Kayla J. Smith, Iain Alexander Murray, Rachel Tanos, John Tellew, Anthony E. Boitano, William H. Bisson, Siva K. Kolluri, Michael P. Cooke, Gary H. Perdew, 2011, Journal of Pharmacology and Experimental Therapeutics on p. 318-327

Antagonism of aryl hydrocarbon receptor signaling by 6,2′,4′- trimethoxyflavone

Iain A. Murray, Colin A. Flaveny, Brett C. DiNatale, Chris R. Chairo, Jennifer C. Schroeder, Ann Kusnadi, Gary H. Perdew, 2010, Journal of Pharmacology and Experimental Therapeutics on p. 135-144