Gary Perdew
Director of the Center for Molecular Toxicology and Carcinogenesis; H. Thomas and Dorothy Willits Hallowell Chair in Agricultural Sciences

-
309 Huck Life Sciences
University Park, PA - ghp2@psu.edu
- 814-865-0400
Research Summary
Mechanisms of receptor-mediated carcinogenesis.
Huck Affiliations
- Integrative and Biomedical Physiology
- Molecular, Cellular, and Integrative Biosciences
- Center for Molecular Toxicology and Carcinogenesis
Links
Publication Tags
These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.
Aryl Hydrocarbon Receptors Ligands Hydrocarbon Microbiota Toxicity Human Ahr Protein Homeostasis Hydrocarbons Dioxins Pharmacological Metabolism Liver Ligand Metabolic Gene Expression Gastrointestinal Microbiome Tryptophan Neoplasms Chemical Activation Keratinocytes Indole Xenobiotics Diet Aryl Hydrocarbon Receptor Antagonist Metabolomics Pharmaceutical PreparationsMost Recent Publications
Xenobiotic Receptor-Mediated Toxicity
GH Perdew, IA Murray, JM Peters,
Effects of the environmental mammary carcinogen 6-nitrochrysene on p53 and p21Cip1 protein expression and cell cycle regulation in MCF-7 and MCF-10A cells
Y. Sun, C. Herzog, J. Krzeminski, S. Amin, Gary Perdew, Chem. Biol. Interaction
Third generation quinoline-3-carboxamide transcriptional disrupter of HDAC4, HIF-1α, and MEF-2 signaling for metastatic castration-resistant prostate cancer
John T. Isaacs, Susan L. Dalrymple, Lizamma Antony, David Marc Rosen, Ilsa M. Coleman, Peter S. Nelson, Maya Kostova, Iain A. Murray, Gary H. Perdew, Samuel R. Denmeade, Emmanuel S. Akinboye, W. Nathaniel Brennen, 2023, Prostate on p. 1470-1493
Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites
Dhwani Patel, Iain A. Murray, Fangcong Dong, Andrew J. Annalora, Krishne Gowda, Denise M. Coslo, Jacek Krzeminski, Imhoi Koo, Fuhua Hao, Shantu G. Amin, Craig B. Marcus, Andrew D. Patterson, Gary H. Perdew, 2023, Metabolites
Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways
A Ganapathy, K Saha, A Wang, P Arumugam, V Dharmaprakash, Gregory Yochum, Walter Koltun, M Nighot, Gary H. Perdew, T Thompson, Thomas Ma, Prashant Nighot, 2023, Cell Reports on p. 112705
Complex chemical signals dictate Ah receptor activation through the gut-lung axis
Fangcong Dong, Iain A. Murray, Andrew Annalora, Denise M. Coslo, Dhimant Desai, Krishne Gowda, Jian Yang, Dingbowen Wang, Imhoi Koo, Fuhua Hao, Shantu G. Amin, Andrew D. Patterson, Craig Marcus, Gary H. Perdew, 2023, FASEB Journal on p. e23010
Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)
Xiaoling Chen, Andrew D. Patterson, Gary H. Perdew, Iain A. Murray, Joshua J. Kellogg, 2023, Journal of Functional Foods
The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022
Gary H. Perdew, Charlotte Esser, Megan Snyder, David H. Sherr, Ellen H. van den Bogaard, Karen McGovern, Pedro M. Fernández-Salguero, Xavier Coumoul, Andrew D. Patterson, 2023, International Journal of Molecular Sciences
Aryl hydrocarbon receptor activation affects nitrergic neuronal survival and delays intestinal motility in mice
Anitha Vijay, Nina R. Boyle, Supriya M. Kumar, Gary H. Perdew, Shanthi Srinivasan, Andrew D. Patterson, 2023, Toxicological Sciences on p. 117-128
Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming
Xiaoliang Zhou, Debopriya Chakraborty, Iain A. Murray, Denise Coslo, Zoe Kehs, Anitha Vijay, Carolyn Ton, Dhimant Desai, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2023, Laboratory Investigation on p. 100012
Most-Cited Papers
Aryl hydrocarbon receptor ligands in cancer: Friend and foe
Iain A. Murray, Andrew D. Patterson, Gary H. Perdew, 2014, Nature Reviews Cancer on p. 801-814
Special section on drug metabolism and the microbiome - Minireview indole and tryptophan metabolism: Endogenous and dietary routes to ah receptor activation
Troy D. Hubbard, Iain A. Murray, Gary H. Perdew, 2015, Drug Metabolism and Disposition on p. 1522-1535
Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation
Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Health Perspectives on p. 679-688
Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles
Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific Reports
Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity
Fangcong Dong, Fuhua Hao, Iain A. Murray, Philip B. Smith, Imhoi Koo, Alyssa Tindall, Penny Kris-Etherton, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary Perdew, 2020, Gut Microbes on p. 1788899
Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation
Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Joost Schalkwijk, Gary H. Perdew, Adam B. Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328
Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice
Limin Zhang, Emmanuel Hatzakis, Robert G. Nichols, Ruixin Hao, Jared Correll, Philip B. Smith, Christopher R. Chiaro, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Science & Technology on p. 8067-8077
Mode of action and dose-response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study
R. A. Budinsky, D. Schrenk, T. Simon, M. Van Den Berg, J. F. Reichard, J. B. Silkworth, L. L. Aylward, A. Brix, T. Gasiewicz, N. Kaminski, G. Perdew, T. B. Starr, N. J. Walker, J. C. Rowlands, 2014, Critical Reviews in Toxicology on p. 83-119
Urolithin a is a dietary microbiota-derived human aryl hydrocarbon receptor antagonist
Gulsum E. Muku, Iain A. Murray, Juan C. Espín, Gary H. Perdew, 2018, Metabolites
Ligand activation of the Ah receptor contributes to gastrointestinal homeostasis
Iain A. Murray, Gary Perdew, 2017, Current Opinion in Toxicology on p. 15-23
News Articles Featuring Gary Perdew
Apr 06, 2023
Broccoli consumption protects gut lining, reduces disease, in mice
Broccoli is known to be beneficial to our health. For example, research has shown that increased consumption of the cruciferous vegetable decreases incidences of cancer and type 2 diabetes.
Full Article
Sep 02, 2022
Metabolomics Core Facility continues to expand while pushing scientific bounds
Established nearly a decade ago, Penn State’s Metabolomics Core Facility is housed in the Huck Institutes of the Life Sciences on the University Park campus.
Full Article
Mar 30, 2020
Examining Links Between AHR, Microbiome, and Immune Functions
Gary Perdew, Ph.D., studies how the aryl hydrocarbon receptor (AHR) pathway interacts with the microbiome, the immune system, and protective barriers in skin and the gut.
Full Article