Gary Perdew

Director of the Center for Molecular Toxicology and Carcinogenesis; John T. and Paige S. Smith Professor in Agricultural Sciences

Gary Perdew

Publication Tags

Aryl Hydrocarbon Receptors Ligands Hydrocarbons Human Ahr Protein Interleukin 6 Skin Microbiota Indican Polychlorinated Biphenyls Chemical Activation Dioxins Anti Inflammatory Agents Genes Response Elements Gene Expression Gastrointestinal Microbiome Sga 360 Modulators 2,8 Dihydroxyquinoline France Kynurenic Acid Cells Metabolism Sulfates Xenobiotics

Most Recent Papers

Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus)

Yuan Tian, Wei Gui, Philip B. Smith, Imhoi Koo, Iain A. Murray, Margherita T. Cantorna, Gary H. Perdew, Andrew D. Patterson, 2019, Journal of agricultural and food chemistry on p. 9286-9294

Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline

Troy D. Hubbard, Qing Liu, Iain A. Murray, Fangcong Dong, Charles Miller, Philip B. Smith, Krishne Gowda, Jyh Ming Lin, Shantu Amin, Andrew D. Patterson, Gary H. Perdew, 2019, Journal of Proteome Research on p. 1715-1724

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

Gulsum E. Muku, Ann Kusnadi, Guray Kuzu, Rachel Tanos, Iain Alexander Murray, Krishne Gowda, Shantu Amin, Gary H. Perdew, 2019, Laboratory Investigation

PCB126 blocks the thermogenic beiging response of adipocytes

Francoise A. Gourronc, Gary H. Perdew, Larry W. Robertson, Aloysius J. Klingelhutz, 2019, Environmental Science and Pollution Research

Urolithin a is a dietary microbiota-derived human aryl hydrocarbon receptor antagonist

Gulsum E. Muku, Iain A. Murray, Juan C. Espín, Gary H. Perdew, 2018, Metabolites

Old receptor, new tricks—The ever-expanding universe of aryl hydrocarbon receptor functions. Report from the 4th AHR meeting, 29–31 August 2018 in Paris, France

Charlotte Esser, B. Paige Lawrence, David H. Sherr, Gary H. Perdew, Alvaro Puga, Robert Barouki, Xavier Coumoul, 2018, International journal of molecular sciences

Structural and Functional Analysis of the Gut Microbiome for Toxicologists

Robert G. Nichols, Jingwei Cai, Iain Alexander Murray, Imhoi Koo, Philip B. Smith, Gary H. Perdew, Andrew David Patterson, 2018, Current Protocols in Toxicology

Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice

Kayla J. Smith, Iain Alexander Murray, Jacob A. Boyer, Gary H. Perdew, 2018, Toxicology on p. 27-34

Assessment of Ah receptor transcriptional activity mediated by halogenated dibenzo-p-dioxins and dibenzofurans (PXDD/Fs) in human and mouse cell systems

Kari L. Organtini, Troy D. Hubbard, Gary H. Perdew, Frank L. Dorman, 2017, Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering on p. 1295-1302

Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses

Gulsum E. Muku, Tejas S. Lahoti, Iain A. Murray, Michael A. Podolsky, Kayla J. Smith, Troy D. Hubbard, Guray Kuzu, Krishne Gowda, Shantu G. Amin, Gary H. Perdew, 2017, Laboratory Investigation on p. 1471-1487

Most-Cited Papers

Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells

Anthony E. Boitano, Jian Wang, Russell Romeo, Laure C. Bouchez, Albert E. Parker, Sue E. Sutton, John R. Walker, Colin A. Flaveny, Gary H. Perdew, Michael S. Denison, Peter G. Schultz, Michael P. Cooke, 2010, Science on p. 1345-1348

Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling

Brett C. DiNatale, Iain A. Murray, Jennifer C. Schroeder, Colin A. Flaveny, Tejas S. Lahoti, Elizabeth M. Laurenzana, Curtis J. Omiecinski, Gary H. Perdew, 2010, Toxicological Sciences on p. 89-97

The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor

Jennifer C. Schroeder, Brett C. DiNatale, Iain A. Murray, Colin A. Flaveny, Qiang Liu, Elizabeth M. Laurenzana, Jyh Ming Lin, Stephen C. Strom, Curtis J. Omiecinski, Shantu Amin, Gary H. Perdew, 2010, Biochemistry on p. 393-400

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental health perspectives on p. 679-688

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific reports

Mechanistic insights into the events that lead to synergistic induction of interleukin 6 transcription upon activation of the aryl hydrocarbon receptor and inflammatory signaling

Brett C. DiNatale, Jennifer C. Schroeder, Lauren J. Francey, Ann Kusnadi, Gary H. Perdew, 2010, Journal of Biological Chemistry on p. 24388-24397

Evidence for ligand-mediated selective modulation of aryl hydrocarbon receptor activity

Iain A. Murray, Jose L. Morales, Colin A. Flaveny, Brett C. DiNatale, Chris Chiaro, Krishnegowda Gowdahalli, Shantu Amin, Gary H. Perdew, 2010, Molecular pharmacology on p. 247-254

Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties

Iain A. Murray, Gowdahalli Krishnegowda, Brett C. Dinatale, Colin Flaveny, Chris Chiaro, Jyh Ming Lin, Arun K. Sharma, Shantu Amin, Gary H. Perdew, 2010, Chemical research in toxicology on p. 955-966

Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism

Kayla J. Smith, Iain Alexander Murray, Rachel Tanos, John Tellew, Anthony E. Boitano, William H. Bisson, Siva K. Kolluri, Michael P. Cooke, Gary H. Perdew, 2011, Journal of Pharmacology and Experimental Therapeutics on p. 318-327

Antagonism of aryl hydrocarbon receptor signaling by 6,2′,4′- trimethoxyflavone

Iain A. Murray, Colin A. Flaveny, Brett C. DiNatale, Chris R. Chairo, Jennifer C. Schroeder, Ann Kusnadi, Gary H. Perdew, 2010, Journal of Pharmacology and Experimental Therapeutics on p. 135-144