Gary Perdew

Director of the Center for Molecular Toxicology and Carcinogenesis; John T. and Paige S. Smith Professor in Agricultural Sciences

Gary Perdew

Publication Tags

Aryl Hydrocarbon Receptors Ligands Human Ahr Protein Genes Interleukin 6 Gene Expression Mouse Ahr Protein Hydrocarbons Chemical Activation Indoleamine Pyrrole 2,3, Dioxygenase Response Elements Indican Skin Colitis Kynurenic Acid Liver Hepatocytes Transcriptional Activation Dioxins Homeostasis Cells Metabolomics Microbiota Sulfates Transcription

Most Recent Papers

Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline

Troy D. Hubbard, Qing Liu, Iain Alexander Murray, Fangcong Dong, Charles Miller, Philip B. Smith, Krishne Gowda, Jyh Ming Lin, Shantu Amin, Andrew David Patterson, Gary H. Perdew, 2019, Journal of Proteome Research on p. 1715-1724

Urolithin a is a dietary microbiota-derived human aryl hydrocarbon receptor antagonist

Gulsum E. Muku, Iain Alexander Murray, Juan C. Espín, Gary H. Perdew, 2018, Metabolites

Old receptor, new tricks—The ever-expanding universe of aryl hydrocarbon receptor functions. Report from the 4th AHR meeting, 29–31 August 2018 in Paris, France

Charlotte Esser, B. Paige Lawrence, David H. Sherr, Gary H. Perdew, Alvaro Puga, Robert Barouki, Xavier Coumoul, 2018, International journal of molecular sciences

Structural and Functional Analysis of the Gut Microbiome for Toxicologists

Robert G. Nichols, Jingwei Cai, Iain Alexander Murray, Imhoi Koo, Philip B. Smith, Gary H. Perdew, Andrew David Patterson, 2018, Current Protocols in Toxicology

Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice

Kerry R. Belton, Yuan Tian, Limin Zhang, Mallappa Anitha, Philip B. Smith, Gary H. Perdew, Andrew David Patterson, 2018, Journal of Proteome Research on p. 1375-1382

Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice

Kayla J. Smith, Iain Alexander Murray, Jacob A. Boyer, Gary H. Perdew, 2018, Toxicology on p. 27-34

Assessment of Ah receptor transcriptional activity mediated by halogenated dibenzo-p-dioxins and dibenzofurans (PXDD/Fs) in human and mouse cell systems

Kari L. Organtini, Troy D. Hubbard, Gary H. Perdew, Franklin Lewis Dorman, Jr., 2017, Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering on p. 1295-1302

Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses

Gulsum E. Muku, Tejas S. Lahoti, Iain Alexander Murray, Michael A. Podolsky, Kayla J. Smith, Troy D. Hubbard, Guray Kuzu, Krishne Gowda, Shantu Amin, Gary H. Perdew, 2017, Laboratory Investigation on p. 1471-1487

Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner

Troy D. Hubbard, Iain Alexander Murray, Robert G. Nichols, Kaitlyn Cassel, Michael Podolsky, Guray Kuzu, Yuan Tian, Philip B. Smith, Mary J. Kennett, Andrew David Patterson, Gary H. Perdew, 2017, Journal of Functional Foods on p. 685-698

Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor

Benjamin J. Moyer, Itzel Y. Rojas, Iain Alexander Murray, Seokwon Lee, Haley F. Hazlett, Gary H. Perdew, Craig R. Tomlinson, 2017, Toxicology and Applied Pharmacology on p. 74-80

High-Impact Papers

Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells

Anthony E. Boitano, Jian Wang, Russell Romeo, Laure C. Bouchez, Albert E. Parker, Sue E. Sutton, John R. Walker, Colin A. Flaveny, Gary H. Perdew, Michael S. Denison, Peter G. Schultz, Michael P. Cooke, 2010, Science on p. 1345-1348

Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling

Brett C. DiNatale, Iain Alexander Murray, Jennifer C. Schroeder, Colin A. Flaveny, Tejas S. Lahoti, Elizabeth M. Laurenzana, Curtis John Omiecinski, Gary H. Perdew, 2010, Toxicological Sciences on p. 89-97

The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor

Jennifer C. Schroeder, Brett C. DiNatale, Iain Alexander Murray, Colin A. Flaveny, Qiang Liu, Elizabeth M. Laurenzana, Jyh ming Lin, Stephen C. Strom, Curtis John Omiecinski, Shantu Amin, Gary H. Perdew, 2010, Biochemistry on p. 393-400

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Limin Zhang, Robert G. Nichols, Jared Correll, Iain Alexander Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew David Patterson, 2015, Environmental health perspectives on p. 679-688

Ligand selectivity and gene regulation by the human aryl hydrocarbon receptor in transgenic mice

Colin A. Flaveny, Iain Alexander Murray, Chris R. Chiaro, Gary H. Perdew, 2009, Molecular Pharmacology on p. 1412-1420

Mechanistic insights into the events that lead to synergistic induction of interleukin 6 transcription upon activation of the aryl hydrocarbon receptor and inflammatory signaling

Brett C. DiNatale, Jennifer C. Schroeder, Lauren J. Francey, Ann Kusnadi, Gary H. Perdew, 2010, Journal of Biological Chemistry on p. 24388-24397

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Troy D. Hubbard, Iain Alexander Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu Amin, Andrew David Patterson, Gary H. Perdew, 2015, Scientific reports

Ah receptor represses acute-phase response gene expression without binding to its cognate response element

Rushang D. Patel, Iain Alexander Murray, Colin A. Flaveny, Ann Kusnadi, Gary H. Perdew, 2009, Laboratory Investigation on p. 695-707

Evidence for ligand-mediated selective modulation of aryl hydrocarbon receptor activity

Iain Alexander Murray, Jose L. Morales, Colin A. Flaveny, Brett C. DiNatale, Chris Chiaro, Krishne Gowda, Shantu Amin, Gary H. Perdew, 2010, Molecular Pharmacology on p. 247-254

Differential gene regulation by the human and mouse aryl hydrocarbon receptor

Colin A. Flaveny, Iain Alexander Murray, Gary H. Perdew, 2009, Toxicological Sciences on p. 217-225