Gary Perdew

Director of the Center for Molecular Toxicology and Carcinogenesis; H. Thomas and Dorothy Willits Hallowell Chair in Agricultural Sciences

Gary Perdew

Research Summary

Mechanisms of receptor-mediated carcinogenesis.

Huck Affiliations

Links

Publication Tags

Aryl Hydrocarbon Receptors Ligands Hydrocarbon Liver Microbiota Chemical Activation Ligand Genes Metabolic Pharmacological Metabolism Dioxins Hydrocarbons Polychlorinated Biphenyls Homeostasis Skin Fatty Acids Bacteria Tryptophan Toxicity Metabolite Epithelial Cells Metabolites Therapeutics Gene Expression Indole

Most Recent Publications

Effects of the environmental mammary carcinogen 6-nitrochrysene on p53 and p21Cip1 protein expression and cell cycle regulation in MCF-7 and MCF-10A cells

Y. Sun, C. Herzog, J. Krzeminski, S. Amin, Gary Perdew, Chem. Biol. Interaction

Early Life Short-Term Exposure to Polychlorinated Biphenyl 126 in Mice Leads to Metabolic Dysfunction and Microbiota Changes in Adulthood

Yuan Tian, Bipin Rimal, Wei Gui, Imhoi Koo, Shigetoshi Yokoyama, Gary H. Perdew, Andrew D. Patterson, 2022, International Journal of Molecular Sciences

Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research

Ethan W. Morgan, Gary H. Perdew, Andrew David Patterson, 2022, Toxicological Sciences on p. 189-213

Gestational Insulin Resistance Is Mediated by the Gut Microbiome–Indoleamine 2,3-Dioxygenase Axis

Medha Priyadarshini, Guadalupe Navarro, Derek J. Reiman, Anukriti Sharma, Kai Xu, Kristen Lednovich, Christopher R. Manzella, Md Wasim Khan, Mariana Salas Garcia, Sarah Allard, Barton Wicksteed, George E. Chlipala, Barbara Szynal, Beatriz Penalver Bernabe, Pauline M. Maki, Ravinder K. Gill, Gary H. Perdew, Jack Gilbert, Yang Dai, Brian T. Layden, 2022, Gastroenterology on p. 1675-1689.e11

The aryl hydrocarbon receptor at the forefront of host-microbe interactions in the skin: A perspective on current knowledge gaps and directions for future research and therapeutic applications

Ellen H. van den Bogaard, Charlotte Esser, Gary H. Perdew, 2021, Experimental Dermatology on p. 1477-1483

The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis

Qing Liu, Limin Zhang, Erik L. Allman, Troy D. Hubbard, Iain A. Murray, Fuhua Hao, Yuan Tian, Wei Gui, Robert G. Nichols, Philip B. Smith, Mallappa Anitha, Gary H. Perdew, Andrew D. Patterson, 2021, Toxicology

The Enigma of AHR Activation in the Skin: Interplay among Ligands, Metabolism, and Bioavailability

Ellen H. van den Bogaard, Gary H. Perdew, 2021, Journal of Investigative Dermatology on p. 1385-1388

How ah receptor ligand specificity became important in understanding its physiological function

Iain A. Murray, Gary H. Perdew, 2020, International Journal of Molecular Sciences on p. 1-19

β-Naphthoflavone activation of the Ah receptor alleviates irradiation-induced intestinal injury in mice

Xiaoliang Zhou, Deguan Li, Wenqing Xu, Heng Zhang, Hao Wang, Gary H. Perdew, 2020, Antioxidants on p. 1-14

Targeting the pregnane X receptor using microbial metabolite mimicry

Zdeněk Dvořák, Felix Kopp, Cait M. Costello, Jazmin S. Kemp, Hao Li, Aneta Vrzalová, Martina Štěpánková, Iveta Bartoňková, Eva Jiskrová, Karolína Poulíková, Barbora Vyhlídalová, Lars U. Nordstroem, Chamini V. Karunaratne, Harmit S. Ranhotra, Kyu Shik Mun, Anjaparavanda P. Naren, Iain A. Murray, Gary H. Perdew, Julius Brtko, Lucia Toporova, Arne Schön, William G. Wallace, William G. Walton, Matthew R. Redinbo, Katherine Sun, Amanda Beck, Sandhya Kortagere, Michelle C. Neary, Aneesh Chandran, Saraswathi Vishveshwara, Maria M. Cavalluzzi, Giovanni Lentini, Julia Yue Cui, Haiwei Gu, John C. March, Shirshendu Chatterjee, Adam Matson, Dennis Wright, Kyle L. Flannigan, Simon A. Hirota, Ryan Balfour Sartor, Sridhar Mani, 2020, EMBO Molecular Medicine

Most-Cited Papers

Special section on drug metabolism and the microbiome - Minireview indole and tryptophan metabolism

Troy D. Hubbard, Iain A. Murray, Gary H. Perdew, 2015, Drug Metabolism and Disposition on p. 1522-1535

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Health Perspectives on p. 679-688

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific Reports

Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice

Limin Zhang, Emmanuel Hatzakis, Robert G. Nichols, Ruixin Hao, Jared Correll, Philip B. Smith, Christopher R. Chiaro, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Science & Technology on p. 8067-8077

Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner

Rachel Tanos, Rushang D. Patel, Iain A. Murray, Philip B. Smith, Andrew D. Patterson, Gary H. Perdew, 2012, Hepatology on p. 1994-2004

Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation

Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Joost Schalkwijk, Gary H. Perdew, Adam B. Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328

Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver

Rachel Tanos, Iain A. Murray, Philip B. Smith, Andrew Patterson, Gary H. Perdew, 2012, Toxicological Sciences on p. 372-379

Mode of action and dose-response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study

R. A. Budinsky, D. Schrenk, T. Simon, M. Van Den Berg, J. F. Reichard, J. B. Silkworth, L. L. Aylward, A. Brix, T. Gasiewicz, N. Kaminski, G. Perdew, T. B. Starr, N. J. Walker, J. C. Rowlands, 2014, Critical Reviews in Toxicology on p. 83-119

Ah receptor antagonism represses head and neck tumor cell aggressive phenotype

Brett C. DiNatale, Kayla Smith, Kaarthik John, Gowdahalli Krishnegowda, Shantu G. Amin, Gary H. Perdew, 2012, Cell Growth and Differentiation on p. 1369-1379

Ligand activation of the Ah receptor contributes to gastrointestinal homeostasis

Iain A. Murray, Gary H. Perdew, 2017, Current Opinion in Toxicology on p. 15-23