Gary Perdew

Director of the Center for Molecular Toxicology and Carcinogenesis; H. Thomas and Dorothy Willits Hallowell Chair in Agricultural Sciences

Gary Perdew

Research Summary

Mechanisms of receptor-mediated carcinogenesis.

Huck Affiliations

Links

Publication Tags

Aryl Hydrocarbon Receptors Ligands Hydrocarbon Microbiota Ligand Chemical Activation Hydrocarbons Liver Metabolic Pharmacological Metabolism Tryptophan Polychlorinated Biphenyls Skin Homeostasis Gastrointestinal Microbiome Dioxins Genes Toxicity Bacteria Metabolomics Metabolite Epithelial Cells Metabolites Human Ahr Protein Neoplasms

Most Recent Publications

Effects of the environmental mammary carcinogen 6-nitrochrysene on p53 and p21Cip1 protein expression and cell cycle regulation in MCF-7 and MCF-10A cells

Y. Sun, C. Herzog, J. Krzeminski, S. Amin, Gary Perdew, Chem. Biol. Interaction

AHR is a master regulator of diverse pathways in endogenous metabolism

Jeffry C. Granados, Kian Falah, Imhoi Koo, Ethan W. Morgan, Gary H. Perdew, Andrew David Patterson, Neema Jamshidi, Sanjay K. Nigam, 2022, Scientific Reports

Early Life Short-Term Exposure to Polychlorinated Biphenyl 126 in Mice Leads to Metabolic Dysfunction and Microbiota Changes in Adulthood

Yuan Tian, Bipin Rimal, Wei Gui, Imhoi Koo, Shigetoshi Yokoyama, Gary H. Perdew, Andrew D. Patterson, 2022, International Journal of Molecular Sciences

Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research

Ethan W. Morgan, Gary H. Perdew, Andrew D. Patterson, 2022, Toxicological Sciences on p. 189-213

Gestational Insulin Resistance Is Mediated by the Gut Microbiome–Indoleamine 2,3-Dioxygenase Axis

Medha Priyadarshini, Guadalupe Navarro, Derek J. Reiman, Anukriti Sharma, Kai Xu, Kristen Lednovich, Christopher R. Manzella, Md Wasim Khan, Mariana Salas Garcia, Sarah Allard, Barton Wicksteed, George E. Chlipala, Barbara Szynal, Beatriz Penalver Bernabe, Pauline M. Maki, Ravinder K. Gill, Gary H. Perdew, Jack Gilbert, Yang Dai, Brian T. Layden, 2022, Gastroenterology on p. 1675-1689.e11

The aryl hydrocarbon receptor at the forefront of host-microbe interactions in the skin: A perspective on current knowledge gaps and directions for future research and therapeutic applications

Ellen H. van den Bogaard, Charlotte Esser, Gary H. Perdew, 2021, Experimental Dermatology on p. 1477-1483

The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis

Qing Liu, Limin Zhang, Erik L. Allman, Troy D. Hubbard, Iain A. Murray, Fuhua Hao, Yuan Tian, Wei Gui, Robert G. Nichols, Philip B. Smith, Mallappa Anitha, Gary H. Perdew, Andrew D. Patterson, 2021, Toxicology

The Enigma of AHR Activation in the Skin: Interplay among Ligands, Metabolism, and Bioavailability

Ellen H. van den Bogaard, Gary H. Perdew, 2021, Journal of Investigative Dermatology on p. 1385-1388

How ah receptor ligand specificity became important in understanding its physiological function

Iain A. Murray, Gary H. Perdew, 2020, International Journal of Molecular Sciences on p. 1-19

β-Naphthoflavone activation of the Ah receptor alleviates irradiation-induced intestinal injury in mice

Xiaoliang Zhou, Deguan Li, Wenqing Xu, Heng Zhang, Hao Wang, Gary H. Perdew, 2020, Antioxidants on p. 1-14

Most-Cited Papers

Aryl hydrocarbon receptor ligands in cancer: Friend and foe

Iain A. Murray, Andrew D. Patterson, Gary H. Perdew, 2014, Nature Reviews Cancer on p. 801-814

Special section on drug metabolism and the microbiome - Minireview indole and tryptophan metabolism: Endogenous and dietary routes to ah receptor activation

Troy D. Hubbard, Iain A. Murray, Gary H. Perdew, 2015, Drug Metabolism and Disposition on p. 1522-1535

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Health Perspectives on p. 679-688

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific Reports

Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice

Limin Zhang, Emmanuel Hatzakis, Robert G. Nichols, Ruixin Hao, Jared Correll, Philip B. Smith, Christopher R. Chiaro, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Science & Technology on p. 8067-8077

Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation

Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Joost Schalkwijk, Gary H. Perdew, Adam B. Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328

Mode of action and dose-response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study

R. A. Budinsky, D. Schrenk, T. Simon, M. Van Den Berg, J. F. Reichard, J. B. Silkworth, L. L. Aylward, A. Brix, T. Gasiewicz, N. Kaminski, G. Perdew, T. B. Starr, N. J. Walker, J. C. Rowlands, 2014, Critical Reviews in Toxicology on p. 83-119

Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity

Fangcong Dong, Fuhua Hao, Iain A. Murray, Philip B. Smith, Imhoi Koo, Alyssa Tindall, Penny Kris-Etherton, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2020, Gut Microbes on p. 1788899

Ligand activation of the Ah receptor contributes to gastrointestinal homeostasis

Iain A. Murray, Gary H. Perdew, 2017, Current Opinion in Toxicology on p. 15-23

Divergent Ah Receptor Ligand Selectivity during Hominin Evolution

Troy D. Hubbard, Iain A. Murray, William H. Bisson, Alexis P. Sullivan, Aswathy Sebastian, George H. Perry, Nina G. Jablonski, Gary H. Perdew, 2016, Molecular Biology and Evolution on p. 2648-2658