Gary Perdew

Director of the Center for Molecular Toxicology and Carcinogenesis; John T. and Paige S. Smith Professor in Agricultural Sciences

Gary Perdew

Research Summary

Mechanisms of receptor-mediated carcinogenesis.

Huck Affiliations

Links

Publication Tags

Aryl Hydrocarbon Receptors Ligands Liver Hydrocarbons Genes Skin Metabolomics Gene Expression Dioxins Chemical Activation Polychlorinated Biphenyls Gastrointestinal Microbiome Human Ahr Protein Estrogens Fatty Acids Neoplasms Response Elements Therapeutics Lipogenesis 2,3,7,8 Tetrachlorodibenzofuran Proteins Estrogen Receptors Cholesterol Microbiota Aryl Hydrocarbon Receptor Nuclear Translocator

Most Recent Papers

Targeting the pregnane X receptor using microbial metabolite mimicry

Zdeněk Dvořák, Felix Kopp, Cait M. Costello, Jazmin S. Kemp, Hao Li, Aneta Vrzalová, Martina Štěpánková, Iveta Bartoňková, Eva Jiskrová, Karolína Poulíková, Barbora Vyhlídalová, Lars U. Nordstroem, Chamini V. Karunaratne, Harmit S. Ranhotra, Kyu Shik Mun, Anjaparavanda P. Naren, Iain A. Murray, Gary H. Perdew, Julius Brtko, Lucia Toporova, Arne Schön, William G. Wallace, William G. Walton, Matthew R. Redinbo, Katherine Sun, Amanda Beck, Sandhya Kortagere, Michelle C. Neary, Aneesh Chandran, Saraswathi Vishveshwara, Maria M. Cavalluzzi, Giovanni Lentini, Julia Yue Cui, Haiwei Gu, John C. March, Shirshendu Chatterjee, Adam Matson, Dennis Wright, Kyle L. Flannigan, Simon A. Hirota, Ryan Balfour Sartor, Sridhar Mani, 2020, EMBO Molecular Medicine

PCB126 blocks the thermogenic beiging response of adipocytes

Francoise A. Gourronc, Gary H. Perdew, Larry W. Robertson, Aloysius J. Klingelhutz, 2020, Environmental Science and Pollution Research on p. 8897-8904

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

Gulsum E. Muku, Ann Kusnadi, Guray Kuzu, Rachel Tanos, Iain A. Murray, Krishne Gowda, Shantu Amin, Gary H. Perdew, 2020, Laboratory Investigation on p. 250-264

Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran

Robert G. Nichols, Jingtao Zhang, Jingwei Cai, Iain A. Murray, Imhoi Koo, Philip B. Smith, Gary H. Perdew, Andrew D. Patterson, 2020, Metabolites

Selective Ah receptor ligands mediate enhanced SREBP1 proteolysis to restrict lipogenesis in sebocytes.

Gulsum E. Muku, Nicholas Blazanin, Fangcong Dong, Philip B. Smith, Diane Thiboutot, Krishne Gowda, Shantu Amin, Iain A. Murray, Gary H. Perdew, 2019, Toxicological Sciences on p. 146-158

Urolithin a is a dietary microbiota-derived human aryl hydrocarbon receptor antagonist

Gulsum E. Muku, Iain A. Murray, Juan C. Espín, Gary H. Perdew, 2018, Metabolites

Old receptor, new tricks—The ever-expanding universe of aryl hydrocarbon receptor functions. Report from the 4th AHR meeting, 29–31 August 2018 in Paris, France

Charlotte Esser, B. Paige Lawrence, David H. Sherr, Gary H. Perdew, Alvaro Puga, Robert Barouki, Xavier Coumoul, 2018, International Journal of Molecular Sciences

Structural and Functional Analysis of the Gut Microbiome for Toxicologists

Robert G. Nichols, Jingwei Cai, Iain Alexander Murray, Imhoi Koo, Philip B. Smith, Gary H. Perdew, Andrew David Patterson, 2018, Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] on p. e54

Metabolomics reveals aryl hydrocarbon receptor activation induces liver and mammary gland metabolic dysfunction in lactating mice

Kerry R. Belton, Yuan Tian, Limin Zhang, Mallappa Anitha, Philip B. Smith, Gary H. Perdew, Andrew David Patterson, 2018, Journal of Proteome Research on p. 1375-1382

Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice

Kayla J. Smith, Iain A. Murray, Jacob A. Boyer, Gary H. Perdew, 2018, Toxicology on p. 27-34

Most-Cited Papers

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Health Perspectives on p. 679-688

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific Reports

Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism

Kayla J. Smith, Iain Alexander Murray, Rachel Tanos, John Tellew, Anthony E. Boitano, William H. Bisson, Siva K. Kolluri, Michael P. Cooke, Gary H. Perdew, 2011, Journal of Pharmacology and Experimental Therapeutics on p. 318-327

Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner

Rachel Tanos, Rushang D. Patel, Iain Alexander Murray, Philip B. Smith, Andrew David Patterson, Gary H. Perdew, 2012, Hepatology on p. 1994-2004

Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice

Limin Zhang, Emmanuel Hatzakis, Robert G. Nichols, Ruixin Hao, Jared Correll, Philip B. Smith, Christopher R. Chiaro, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Science & Technology on p. 8067-8077

Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver

Rachel Tanos, Iain A. Murray, Philip B. Smith, Andrew Patterson, Gary H. Perdew, 2012, Toxicological Sciences on p. 372-379

Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation

Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Joost Schalkwijk, Gary H. Perdew, Adam B. Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328

Ah receptor antagonism inhibits constitutive and cytokine inducible IL6 production in head and neck tumor cell lines

Brett C. DiNatale, Jennifer C. Schroeder, Gary H. Perdew, 2011, Molecular Carcinogenesis on p. 173-183

Distinct roles for Aryl hydrocarbon receptor nuclear translocator and Ah receptor in estrogen-mediated signaling in human cancer cell lines

Mark P. Labrecque, Mandeep K. Takhar, Brett D. Hollingshead, Gratien G. Prefontaine, Gary H. Perdew, Timothy V. Beischlag, 2012, PLoS One

Ah receptor antagonism represses head and neck tumor cell aggressive phenotype

Brett C. DiNatale, Kayla Smith, Kaarthik John, Gowdahalli Krishnegowda, Shantu G. Amin, Gary H. Perdew, 2012, Molecular Cancer Research on p. 1369-1379