Kumble Sandeep Prabhu

Professor of Immunology and Molecular Toxicology

Kumble Sandeep Prabhu

Research Summary

Molecular mechanisms by which bioactives such as selenium, omega-3 fatty acids, and other products of natural origin alter the host response and immune function in inflammation and cancer

Huck Graduate Students

Huck Affiliations

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Publication Tags

Selenium Selenoproteins Macrophages Inflammation Prostaglandins Selenocysteine Lipopolysaccharides Neoplasms Proteins Chemical Activation Genes Cyclopentenone Stem Cells Mass Spectrometry Ligands Ppar Gamma Citrobacter Rodentium P38 Mitogen Activated Protein Kinases Calcium Omega 3 Fatty Acids Acetylation Heme Prostaglandins D Erythropoietin Receptors Platelet Activating Factor

Most Recent Papers

Selenium-dependent metabolic reprogramming during inflammation and resolution

Arvind M. Korwar, Ayaan Hossain, Tai Jung Lee, Ashley E. Shay, Venkatesha Basrur, Kevin Conlon, Philip B. Smith, Bradley A. Carlson, Howard M. Salis, Andrew D. Patterson, K. Sandeep Prabhu, 2021, Journal of Biological Chemistry

Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation

Yuanting Chen, Jie Xiang, Fenghua Qian, Bastihalli T. Diwakar, Baiye Ruan, Siyang Hao, K. Sandeep Prabhu, Robert F. Paulson, 2020, Blood on p. 235-246

The essential role of selenoproteins in the resolution of citrobacter rodentium-induced intestinal inflammation

Shaneice K. Nettleford, Luming Zhao, Fenghua Qian, Morgan Herold, Brooke Arner, Dhimant Desai, Shantu Amin, Na Xiong, Vishal Singh, Bradley A. Carlson, K. Sandeep Prabhu, 2020, Frontiers in Nutrition

Selenium and selenoproteins in prostanoid metabolism and immunity

Fenghua Qian, Sougat Misra, K. Sandeep Prabhu, 2019, Critical Reviews in Biochemistry and Molecular Biology on p. 484-516

p38 MAP-kinase inhibitor protects against platelet-activating factor-induced death in mice

Kandahalli Venkataranganayaka Abhilasha, Mosale Seetharam Sumanth, Vyala Hanumanthareddy Chaithra, Shancy Petsel Jacob, Anita Thyagarajan, Ravi Prakash Sahu, Rajesh Rajaiah, K. Sandeep Prabhu, Kempaiah Kemparaju, Jeffrey Bryant Travers, Chu Huang Chen, Gopal Kedihithlu Marathe, 2019, Free Radical Biology and Medicine on p. 275-287

Special Issue of “Optimal Selenium Status and Selenoproteins in Health”

Wen Hsing Cheng, K. Sandeep Prabhu, 2019, Biological Trace Element Research

Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-αB activation in murine macrophages via changes in intracellular calcium

Bastihalli T. Diwakar, Ryan Yoast, Shaneice Nettleford, Fenghua Qian, Tai Jung Lee, Svanjita Berry, Ian Huffnagle, Randall M. Rossi, Mohamed Trebak, Robert F. Paulson, K. Sandeep Prabhu, 2019, FASEB Journal on p. 12838-12852

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

Laura F. Bennett, Chang Liao, Michael D. Quickel, Beng San Yeoh, Matam Vijay-Kumar, Pamela Hankey-Giblin, K. Sandeep Prabhu, Robert F. Paulson, 2019, Science Signaling

Acute phase protein, α – 1- acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses

Mosale Seetharam Sumanth, Kandahalli Venkataranganayaka Abhilasha, Shancy Petsel Jacob, Vyala Hanumanthareddy Chaithra, Venkatesha Basrur, Belinda Willard, Thomas M. McIntyre, K. Sandeep Prabhu, Gopal K. Marathe, 2019, Immunobiology on p. 672-680

Selenoproteome Identification in Inflamed Murine Primary Bone Marrow-Derived Macrophages by Nano-LC Orbitrap Fusion Tribrid Mass Spectrometry

Arvind M. Korwar, Ashley E. Shay, Venkatesha Basrur, Kevin Conlon, K. Sandeep Prabhu, 2019, Journal of the American Society for Mass Spectrometry on p. 1276-1283

Most-Cited Papers

Selenoprotein gene nomenclature

Brigelius Flohé Regina, Vadim N. Gladyshev, Elias S. Arnér, Marla J. Berry, Elspeth A. Bruford, Raymond F. Burk, Bradley A. Carlson, Sergi Castellano, Laurent Chavatte, Marcus Conrad, Paul R. Copeland, Alan M. Diamond, Donna M. Driscoll, Ana Ferreiro, Leopold Flohé, Fiona R. Green, Roderic Guigó, Diane E. Handy, Dolph L. Hatfield, John Hesketh, Peter R. Hoffmann, Arne Holmgren, Robert J. Hondal, Michael T. Howard, Kaixun Huang, Hwa Young Kim, Ick Young Kim, Josef Köhrle, Alain Krol, Gregory V. Kryukov, Byeong Jae Lee, Byung Cheon Lee, Xin Gen Lei, Qiong Liu, Alain Lescure, Alexei V. Lobanov, Joseph Loscalzo, Matilde Maiorino, Marco Mariotti, K. Sandeep Prabhu, Margaret P. Rayman, Sharon Rozovsky, Gustavo Salinas, Edward E. Schmidt, Lutz Schomburg, Ulrich Schweizer, Miljan Simonović, Roger A. Sunde, Petra A. Tsuji, Susan Tweedie, F. Fulvio Ursini, Philip D. Whanger, Yan Zhang, 2016, Journal of Biological Chemistry on p. 24036-24040

Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D <sub>2</sub> synthase in macrophages is mediated through the activation of Peroxisome Proliferator-activated Receptor (PPAR) γ

Ujjawal H. Gandhi, Naveen Kaushal, Kodihalli C. Ravindra, Shailaja Hegde, Shakira M. Nelson, Vivek Narayan, Hema Vunta, Robert F. Paulson, K. Sandeep Prabhu, 2011, Journal of Biological Chemistry on p. 27471-27482

Is selenium a potential treatment for cancer metastasis?

Yu Chi Chen, K. Sandeep Prabhu, Andrea M. Mastro, 2013, Nutrients on p. 1149-1168

Selenium levels affect the IL-4-induced expression of alternative activation markers in murine macrophages

Shakira M. Nelson, Xingen Lei, K. Sandeep Prabhu, 2011, Journal of Nutrition on p. 1754-1761

Selenium and inflammatory bowel disease

Avinash K. Kudva, Ashley E. Shay, K. Sandeep Prabhu, 2015, American Journal of Physiology on p. G71-G77

Dietary selenium supplementation modifies breast tumor growth and metastasis

Yu Chi Chen, Kumble Sandeep Prabhu, Arunangshu Das, Andrea Marie Mastro, 2013, International Journal of Cancer on p. 2054-2064

Δ <sup>12</sup>-prostaglandin J <sub>3</sub>, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice

Shailaja Hegde, Naveen Kaushal, Kodihalli C. Ravindra, Christopher Chiaro, Kelsey T. Hafer, Ujjawal H. Gandhi, Jerry T. Thompson, John Patrick Vanden Heuvel, Mary J. Kennett, Pamela Hankey Giblin, Robert Paulson, Kumble Sandeep Prabhu, 2011, Blood on p. 6909-6919

Epigenetic regulation of inflammatory gene expression in macrophages by selenium

Vivek Narayan, Kodihalli C. Ravindra, Chang Liao, Naveen Kaushal, Bradley A. Carlson, Kumble Sandeep Prabhu, 2015, Journal of Nutritional Biochemistry on p. 138-145

Crucial role of macrophage selenoproteins in experimental colitis

Naveen Kaushal, Avinash K. Kudva, Andrew D. Patterson, Christopher Chiaro, Mary J. Kennett, Dhimant Desai, Shantu Amin, Bradley A. Carlson, Margherita T. Cantorna, K. Sandeep Prabhu, 2014, Journal of Immunology on p. 3683-3692

The microbiome and obesity-An established risk for certain types of cancer

Connie J. Rogers, Kumble Sandeep Prabhu, Matam Vijay-Kumar, 2014, Cancer Journal from Scientific American on p. 176-180