Kumble Sandeep Prabhu

Professor of Immunology and Molecular Toxicology

Kumble Sandeep Prabhu

Research Summary

Molecular mechanisms by which bioactives such as selenium, omega-3 fatty acids, and other products of natural origin alter the host response and immune function in inflammation and cancer

Graduate Students

Huck Affiliations


Publication Tags

Macrophages Selenium Selenoproteins Prostaglandins Lipopolysaccharides Proteins Cyclopentenone Genes Selenocysteine Inflammation Erythropoiesis Chemical Activation Ligands Down Regulation Gene Expression Mass Spectrometry Arachidonic Acid Omega 3 Fatty Acids Calcium Prostaglandins D Acetylation Melanoma P38 Mitogen Activated Protein Kinases Terminology Stem Cells

Most Recent Papers

Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages via changes in intracellular calcium

Bastihalli T. Diwakar, Ryan Yoast, Shaneice Nettleford, Fenghua Qian, Tai Jung Lee, Svanjita Berry, Ian Huffnagle, Randall M. Rossi, Mohamed Trebak, Robert F. Paulson, K. Sandeep Prabhu, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology on p. 12838-12852

p38 MAP-kinase inhibitor protects against platelet-activating factor-induced death in mice

Kandahalli Venkataranganayaka Abhilasha, Mosale Seetharam Sumanth, Vyala Hanumanthareddy Chaithra, Shancy Petsel Jacob, Anita Thyagarajan, Ravi Prakash Sahu, Rajesh Rajaiah, Kumble Sandeep Prabhu, Kempaiah Kemparaju, Jeffrey Bryant Travers, Chu Huang Chen, Gopal Kedihithlu Marathe, 2019, Free Radical Biology and Medicine on p. 275-287

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

Laura F. Bennett, Chang Liao, Michael D. Quickel, Beng San Yeoh, Matam Vijay-Kumar, Pamela Hankey-Giblin, K. Sandeep Prabhu, Robert F. Paulson, 2019, Science signaling

Acute phase protein, α – 1- acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses

Mosale Seetharam Sumanth, Kandahalli Venkataranganayaka Abhilasha, Shancy Petsel Jacob, Vyala Hanumanthareddy Chaithra, Venkatesha Basrur, Belinda Willard, Thomas M. McIntyre, K. Sandeep Prabhu, Gopal K. Marathe, 2019, Immunobiology on p. 672-680

Selenoproteome Identification in Inflamed Murine Primary Bone Marrow-Derived Macrophages by Nano-LC Orbitrap Fusion Tribrid Mass Spectrometry

Arvind M. Korwar, Ashley E. Shay, Venkatesha Basrur, Kevin Conlon, K. Sandeep Prabhu, 2019, Journal of the American Society for Mass Spectrometry on p. 1276-1283

Selenium-rich maize modulates the expression of prostaglandin genes in lipopolysaccharide-stimulated RAW264.7 macrophages

Noorpreet I. Dhanjal, Siddharth Sharma, Anatoly V. Skalny, Margarita G. Skalnaya, Olga P. Ajsuvakova, Alexey A. Tinkov, Feng Zhang, Xiong Guo, K. Sandeep Prabhu, N. Tejo Prakash, 2019, Food and Function on p. 2839-2846

Downregulation of CD73 associates with T cell exhaustion in AML patients

Yaxian Kong, Bei Jia, Chenchen Zhao, David Claxton, Arati Sharma, Charyguly Annageldiyev, Joseph Fotos, Hui Zeng, Robert Paulson, Kumble Sandeep Prabhu, Hong Zheng, 2019, Journal of Hematology and Oncology

Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia

Chang Liao, K. Sandeep Prabhu, Robert F. Paulson, 2018, Blood on p. 2580-2593

Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis

Chang Liao, Ross Cameron Hardison, Mary J. Kennett, Bradley A. Carlson, Robert Paulson, Kumble Sandeep Prabhu, 2018, Blood on p. 2568-2580

Bioaccessible selenium sourced from Se-rich mustard cake facilitates protection from TBHP induced cytotoxicity in melanoma cells

Sumit K. Jaiswal, Ranjana Prakash, Kumble Sandeep Prabhu, N. Tejo Prakash, 2018, Food and Function on p. 1998-2004

Most-Cited Papers

Selenoprotein gene nomenclature

Brigelius Flohé Regina, Vadim N. Gladyshev, Elias S. Arnér, Marla J. Berry, Elspeth A. Bruford, Raymond F. Burk, Bradley A. Carlson, Sergi Castellano, Laurent Chavatte, Marcus Conrad, Paul R. Copeland, Alan M. Diamond, Donna M. Driscoll, Ana Ferreiro, Leopold Flohé, Fiona R. Green, Roderic Guigó, Diane E. Handy, Dolph L. Hatfield, John Hesketh, Peter R. Hoffmann, Arne Holmgren, Robert J. Hondal, Michael T. Howard, Kaixun Huang, Hwa Young Kim, Ick Young Kim, Josef Köhrle, Alain Krol, Gregory V. Kryukov, Byeong Jae Lee, Byung Cheon Lee, Xin Gen Lei, Qiong Liu, Alain Lescure, Alexei V. Lobanov, Joseph Loscalzo, Matilde Maiorino, Marco Mariotti, K. Sandeep Prabhu, Margaret P. Rayman, Sharon Rozovsky, Gustavo Salinas, Edward E. Schmidt, Lutz Schomburg, Ulrich Schweizer, Miljan Simonović, Roger A. Sunde, Petra A. Tsuji, Susan Tweedie, F. Fulvio Ursini, Philip D. Whanger, Yan Zhang, 2016, Journal of Biological Chemistry on p. 24036-24040

Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D <sub>2</sub> synthase in macrophages is mediated through the activation of Peroxisome Proliferator-activated Receptor (PPAR) γ

Ujjawal H. Gandhi, Naveen Kaushal, Kodihalli C. Ravindra, Shailaja Hegde, Shakira M. Nelson, Vivek Narayan, Hema Vunta, Robert F. Paulson, K. Sandeep Prabhu, 2011, Journal of Biological Chemistry on p. 27471-27482

Dietary selenium supplementation modifies breast tumor growth and metastasis

Yu Chi Chen, Kumble Sandeep Prabhu, Arunangshu Das, Andrea Marie Mastro, 2013, International Journal of Cancer on p. 2054-2064

Δ <sup>12</sup>-prostaglandin J <sub>3</sub>, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice

Shailaja Hegde, Naveen Kaushal, Kodihalli C. Ravindra, Christopher Chiaro, Kelsey T. Hafer, Ujjawal H. Gandhi, Jerry T. Thompson, John Patrick Vanden Heuvel, Mary J. Kennett, Pamela Hankey Giblin, Robert Paulson, Kumble Sandeep Prabhu, 2011, Blood on p. 6909-6919

Selenium levels affect the IL-4-induced expression of alternative activation markers in murine macrophages

Shakira M. Nelson, Xingen Lei, K. Sandeep Prabhu, 2011, Journal of Nutrition on p. 1754-1761

Inhibition of TLR4-induced IκB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein

Manujendra Ray, Shan Yu, Daniel R. Sharda, Caleph B. Wilson, Qingping Liu, Naveen Kaushal, K. Sandeep Prabhu, Pamela A. Hankey, 2010, Journal of Immunology on p. 7309-7316

Epigenetic regulation of inflammatory gene expression in macrophages by selenium

Vivek Narayan, Kodihalli C. Ravindra, Chang Liao, Naveen Kaushal, Bradley A. Carlson, Kumble Sandeep Prabhu, 2015, Journal of Nutritional Biochemistry on p. 138-145

The regulation of erythropoiesis by selenium in mice

Naveen Kaushal, Shailaja Hegde, Jeanne Ann Lumadue, Robert Paulson, Kumble Sandeep Prabhu, 2011, Antioxidants and Redox Signaling on p. 1403-1412

Celastrol inhibits tat-mediated human immunodeficiency virus (HIV) transcription and replication

Vivek Narayan, Kodihalli C. Ravindra, Chris Chiaro, Daniele Cary, Bharat B. Aggarwal, Andrew J. Henderson, Kumble Sandeep Prabhu, 2011, Journal of Molecular Biology on p. 972-983

Total synthesis of Δ¹²-prostaglandin J₃, a highly potent and selective antileukemic agent

K. C. Nicolaou, Philipp Heretsch, Abdelatif ElMarrouni, Christopher R.H. Hale, Kiran K. Pulukuri, Avinash K. Kudva, Vivek Narayan, Kumble Sandeep Prabhu, 2014, Angewandte Chemie (International ed. in English) on p. 10443-10447