Kumble Sandeep Prabhu

Professor of Immunology and Molecular Toxicology

101 Henning
University Park, PA 16802
ksp4@psu.edu
814-863-8976

Research Summary

Molecular mechanisms by which bioactives such as selenium, omega-3 fatty acids, and other products of natural origin alter the host response and immune function in inflammation and cancer

Huck Graduate Students

Huck Affiliations

Integrative and Biomedical Physiology

Molecular, Cellular, and Integrative Biosciences

Center for Molecular Toxicology and Carcinogenesis

Publication Tags

Selenium Selenoproteins Macrophages Inflammation Prostaglandins Neoplasms Selenocysteine Proteins Genes Prostanoid Chemical Activation Lipopolysaccharides Inflammatory Bowel Diseases Metabolism Lipids Pharmacological Metabolism Ligands Acetylation Erythropoietin Receptors Calcium Neoplasm Metastasis Citrobacter Rodentium P38 Mitogen Activated Protein Kinases Cyclopentenone Heme

Most Recent Publications

Correlation of Serum Selenium in Asthma Patients with Severity of the Disorder

Nidhi Girdhar, Heena Kansal, Kranti Garg, Siddharth Sharma, K. Sandeep Prabhu, Vishal Chopra, Alexey A. Tinkov, Anatoly V. Skalny, N. Tejo Prakash, 2022, Biological Trace Element Research on p. 4949-4954

A novel clinically relevant graft-versus-leukemia model in humanized mice

Bei Jia, Chenchen Zhao, Michael Bayerl, Hiroko Shike, David F. Claxton, W. Christopher Ehmann, Shin Mineishi, Todd D. Schell, Pan Zheng, Yi Zhang, Leonard D. Shultz, K. Sandeep Prabhu, Robert F. Paulson, Hong Zheng, 2021, Journal of Leukocyte Biology

Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation

Yuanting Chen, Jie Xiang, Fenghua Qian, Bastihalli T. Diwakar, Baiye Ruan, Siyang Hao, K. Sandeep Prabhu, Robert F. Paulson, 2020, Blood on p. 235-246

The Essential Role of Selenoproteins in the Resolution of Citrobacter rodentium-Induced Intestinal Inflammation

Shaneice K. Nettleford, Luming Zhao, Fenghua Qian, Morgan Herold, Brooke Arner, Dhimant Desai, Shantu Amin, Na Xiong, Vishal Singh, Bradley A. Carlson, K. Sandeep Prabhu, 2020, Frontiers in Nutrition

Selenium and selenoproteins in prostanoid metabolism and immunity

Fenghua Qian, Sougat Misra, K. Sandeep Prabhu, 2019, Critical Reviews in Biochemistry and Molecular Biology on p. 484-516

Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-αB activation in murine macrophages via changes in intracellular calcium

Bastihalli T. Diwakar, Ryan Yoast, Shaneice Nettleford, Fenghua Qian, Tai Jung Lee, Svanjita Berry, Ian Huffnagle, Randall M. Rossi, Mohamed Trebak, Robert F. Paulson, K. Sandeep Prabhu, 2019, FASEB Journal on p. 12838-12852

p38 MAP-kinase inhibitor protects against platelet-activating factor-induced death in mice

Kandahalli Venkataranganayaka Abhilasha, Mosale Seetharam Sumanth, Vyala Hanumanthareddy Chaithra, Shancy Petsel Jacob, Anita Thyagarajan, Ravi Prakash Sahu, Rajesh Rajaiah, K. Sandeep Prabhu, Kempaiah Kemparaju, Jeffrey Bryant Travers, Chu Huang Chen, Gopal Kedihithlu Marathe, 2019, Free Radical Biology and Medicine on p. 275-287

Special Issue of “Optimal Selenium Status and Selenoproteins in Health”

Wen Hsing Cheng, K. Sandeep Prabhu, 2019, Biological Trace Element Research

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

Laura F. Bennett, Chang Liao, Michael D. Quickel, Beng San Yeoh, Matam Vijay-Kumar, Pamela Hankey-Giblin, K. Sandeep Prabhu, Robert F. Paulson, 2019, Science's STKE : signal transduction knowledge environment

Acute phase protein, α – 1- acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses

Mosale Seetharam Sumanth, Kandahalli Venkataranganayaka Abhilasha, Shancy Petsel Jacob, Vyala Hanumanthareddy Chaithra, Venkatesha Basrur, Belinda Willard, Thomas M. McIntyre, K. Sandeep Prabhu, Gopal K. Marathe, 2019, Zeitschrift für Immunitätsforschung und experimentelle Therapie on p. 672-680

Most-Cited Papers

Selenoprotein gene nomenclature

Brigelius Flohé Regina, Vadim N. Gladyshev, Elias S. Arnér, Marla J. Berry, Elspeth A. Bruford, Raymond F. Burk, Bradley A. Carlson, Sergi Castellano, Laurent Chavatte, Marcus Conrad, Paul R. Copeland, Alan M. Diamond, Donna M. Driscoll, Ana Ferreiro, Leopold Flohé, Fiona R. Green, Roderic Guigó, Diane E. Handy, Dolph L. Hatfield, John Hesketh, Peter R. Hoffmann, Arne Holmgren, Robert J. Hondal, Michael T. Howard, Kaixun Huang, Hwa Young Kim, Ick Young Kim, Josef Köhrle, Alain Krol, Gregory V. Kryukov, Byeong Jae Lee, Byung Cheon Lee, Xin Gen Lei, Qiong Liu, Alain Lescure, Alexei V. Lobanov, Joseph Loscalzo, Matilde Maiorino, Marco Mariotti, K. Sandeep Prabhu, Margaret P. Rayman, Sharon Rozovsky, Gustavo Salinas, Edward E. Schmidt, Lutz Schomburg, Ulrich Schweizer, Miljan Simonović, Roger A. Sunde, Petra A. Tsuji, Susan Tweedie, F. Fulvio Ursini, Philip D. Whanger, Yan Zhang, 2016, Journal of Biological Chemistry on p. 24036-24040

Is selenium a potential treatment for cancer metastasis?

Yu Chi Chen, K. Sandeep Prabhu, Andrea M. Mastro, 2013, Nutrients on p. 1149-1168

Selenium and inflammatory bowel disease

Avinash K. Kudva, Ashley E. Shay, K. Sandeep Prabhu, 2015, American Journal of Physiology on p. G71-G77

Dietary selenium supplementation modifies breast tumor growth and metastasis

Yu Chi Chen, K. Sandeep Prabhu, Arunangshu Das, Andrea M. Mastro, 2013, International Journal of Cancer on p. 2054-2064

Crucial role of macrophage selenoproteins in experimental colitis

Naveen Kaushal, Avinash K. Kudva, Andrew D. Patterson, Christopher Chiaro, Mary J. Kennett, Dhimant Desai, Shantu Amin, Bradley A. Carlson, Margherita T. Cantorna, K. Sandeep Prabhu, 2014, Journal of Immunology on p. 3683-3692

Selenium

K. Sandeep Prabhu, Xin Gen Lei, 2016, Advances in nutrition (Bethesda, Md.) on p. 415-417

Epigenetic regulation of inflammatory gene expression in macrophages by selenium

Vivek Narayan, Kodihalli C. Ravindra, Chang Liao, Naveen Kaushal, Bradley A. Carlson, K. Sandeep Prabhu, 2015, Nutrition Reports International on p. 138-145

The microbiome and obesity-An established risk for certain types of cancer

Connie J. Rogers, Kumble Sandeep Prabhu, Matam Vijay-Kumar, 2014, Cancer Journal from Scientific American on p. 176-180

Selenium and selenoproteins in gut inflammation—A review

Shaneice K. Nettleford, K. Sandeep Prabhu, 2018, Antioxidants