Penn State University

X-Ray Crystallography Facility

Providing training, assistance and expertise in crystallizing and determining the three-dimensional structures of proteins and other biological macromolecules
X-ray crystallography is the chief method for determining the atomic resolution three-dimensional structures of biological macromolecules. The focus of the facility is to provide the necessary infrastructure and support for individual investigators to undertake single crystal X-ray structural studies. We provide instrumentation, training and collaboration for:
  • Protein characterization including dynamic light scattering, differential scanning calorimetry, bio-layer interferometry and circular dichroism
  • Binding studies using isothermal titration calorimetry

  • Robotic crystallization, incubators, UV and digital microscopes 
  • Robotic imaging
  • Diffraction data collection and processing
  • Structure determination and analysis
  • Molecular modeling
  • Small angle X-ray scattering
Our experienced staff are available to train researchers to use equipment and to assist project development and research.
Please contact the Facility to schedule equipment use or training.