Collage for hero banner of microbes

One Health Microbiome Center

As one of the largest and most active organizations in the field, the internationally awarded One Health Microbiome Center has a mission to optimize, accelerate, and disseminate long-lasting applications and knowledge on the microbiome.

Microbiomes are communities of microorganisms (e.g., bacteria, fungi, viruses, archaea, and protozoa) that inhabit an environment, including plants, animals, soils, oceans, and our homes. As we peer into our bodies, half of the cells in a human are microbes, and the gene catalogue of these human-associated microbes dwarfs that of our own human genome by at least 100-fold. Members of the microbiome can range from helpful to harmful, but notably the vast majority do not cause disease. As a collective, microbial assemblages and their genomes have profound impacts on solutions related to agricultural production, human chronic diseases, and ecosystem stability, among others. As we break ground on understanding how these diverse communities impact life, it is clear that the new study of the microbiome is central to biological systems, education, and applications in a rapidly changing world.

The center deeply embodies my vision for growing interdisciplinary excellence

—Penn State President Neeli Bendapudi, November 2024

550

Members

$224M

Awarded Funding

42+

Departments

100

Country Collaborations

9

American Academy of Microbiology Fellows

2000+

Publications in a Five-Year Period

First Ph.D

In Microbiome Science

Pierce Prize

First Ever Awarded to a Center, Not an Individual

News

One Health Microbiome Center names next doctoral interns for industry program

Penn State graduate students Natalie Ford and Mackenna Yount will spend this summer engaging in hands-on research with industry experts at the Hilden, Germany, headquarters of QIAGEN, a global leader in biotechnology for life sciences diagnostics, equipment and research.

New clues for using common fungus to promote crop growth and health

Trichoderma species — a common fungus found in soils — have varying abilities to promote tomato plant growth and differentially affect the abundance of certain soil bacteria, according to a study led by researchers at Penn State. The work was the latest in a line of research evaluating the use of this common group of fungi as an alternative to pesticides for controlling soilborne pathogens, said Seogchan Kang, professor in the College of Agricultural Sciences and co-corresponding author of the study.

Connected habitats help wildlife fight disease, strengthen protective microbes

A team led by Penn State biologists found that amphibians in connected natural forests and aquatic habitats were more likely to host beneficial skin microbes that inhibit a deadly fungal pathogen. But when these habitats become spatially separated due to planted crops, infrastructure development or other human land use, those microbial defenses weaken and pathogen infection levels can increase with potentially deadly results.

Plant scientists receive $1.96M NIH grant to study plant-bacteria partnerships

A team of plant scientists in Penn State’s College of Agricultural Sciences has received a $1.96 million, five-year grant from the National Institutes of Health (NIH) to fund a study of how beneficial plant-bacteria partnerships evolve, persist, and can be harnessed to improve health and agriculture. This grant, called a Maximizing Investigator’s Research Award, supports a lab's long-term research vision rather than an individual project.