TA Instruments Affinity ITC auto

The Affinity ITC Auto is designed for the most challenging life science laboratory environments that require high sensitivity, high productivity and the most advanced ITC technologies. The Affinity ITC brings advanced engineering to all critical aspects of the measurement ensuring the highest quality ITC data.

Affinity-ITC Auto


  • AccuShot™ delivers the titrant to the right location for the best mixing
  • FlexSpin™ provides innovative slow speed stirring, efficient mixing and highest sensitivity
  • Fully automated, user-selectable system cleaning routines eliminate run-to-run contamination
  • Intelligent Hardware Positioning for precise reliable injections
  • Solid-state active heating and cooling for true isothermal temperature control
  • Choice of standard volume (1.0 mL) or low volume cells (190 µL)
  • Industry proven 96-well, temperature-controlled liquid handling autosampler. Autosampler can be included with initial purchase or added at a later date
  • Powerful ITCRun and NanoAnalyze for the most comprehensive suite of tools for method optimization, model fitting, batch analysis, graphing and data export.


  • Characterization of molecular interactions of small molecules, proteins, antibodies, nucleic acids, lipids and other biomolecules
  • Enzyme kinetics
  • Assessment of molecular structure changes on binding mechanisms
  • Specifications
  • Operating temperature: 2°C to 80°C
  • Autosampler storage temperature: 4°C to ambient
  • Response time: 3.3 seconds
  • Cell design: 185uL active volume cylindrical cell
  • Injection syringe: up to 270uL
  • Usable syringe volume: 100µl
  • Smallest injection size: 0.1µl
  • Stirring speed: up to 200 rpm
  • Full Automation 24K Gold cell


Contributions made by data from this instrument may be acknowledged in papers with language similar to the example below:

We would like to thank Ms. Julia Fecko and Dr. Neela Yennawar for the helpful discussions for the ITC binding study. The work was supported by the NIH grant S10OD025145 to Dr. Yennawar for the TA Instruments Low Volume AutoAffinity ITC, housed in the Automated Biological Calorimetry core facility at Penn State's Huck Institutes of the Life Sciences.