Isothermal Titration Calorimetry

Isothermal titration calorimetry (ITC) is a technique that measures the heat absorbed or released during a binding event. Integrating the raw data leads to the calculation of the enthalpy of binding. A curve is fit with an appropriate model using the data plot of the enthalpy and ligand-to-macromolecule mole ratio. From this curve the thermodynamic parameters, namely the stoichiometry, dissociation constant, and binding entropy, are obtained.


MicroCal Auto-iTC200

The Auto-iTC200 combines the performance of the most sensitive isothermal titration calorimeter available with full automation.

TA Instruments Affinity ITC auto

The Affinity ITC Auto is designed for the most challenging life science laboratory environments that require high sensitivity, high productivity and the most advanced ITC technologies.