Bioinformatics And Genomics News | Bioinformatics and Genomics

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Oct 25, 2024

Re-engineered, blue light-activated immune cells penetrate and kill solid tumors

A team led by researchers from the Penn State College of Medicine has re-engineered immune cells so that they can penetrate and kill solid tumors grown in the lab.

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Researchers developed a 3D atlas of the developing mouse brain, with such images as this. Credit: Provided by the Kim Lab / Penn State. Creative Commons

Oct 22, 2024

Researchers develop 3D atlas of the developing mammalian brain

A 3D atlas of developing mice brains using advanced imaging and microscopy techniques has been created by a team of researchers at Penn State College of Medicine and collaborators from five different institutes.

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Brianna Hnath, left, is doctoral candidate in biomedical engineering at Penn State and co-author of the study. Credit: Courtesy of the Dokholyan lab / Penn State. Creative Commons

Oct 14, 2024

Toxic protein may contribute to ALS development

New study elucidates the physiological processes that may contribute to ALS development and identifies a potential therapeutic target

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The researchers collected 58 bulk tank milk samples and applied various AI algorithms to differentiate between baseline samples and those representing potential anomalies, such as milk from an outside farm or milk containing antibiotics. Credit: SeanShot/Getty Images. All Rights Reserved.

Oct 11, 2024

AI decodes microbes’ message in milk safety testing approach

By combining the genetic sequencing and analysis of the microbes in a milk sample with artificial intelligence (AI), researchers were able to detect anomalies in milk production, such as contamination or unauthorized additives.

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New experimental technique developed by Penn State researchers helps uncover how certain proteins cooperate to bind to otherwise closed regions of the genome to facilitate cell differentiation and development. Illustration shows expanded view of chromosome from a cell at the upper left. The “pioneer factor” FOXA1 co-binds with AP-1, allowing FOXA1 to locate target sites in the genome with high specificity. Credit: Holly Godin/Bai Laboratory / Penn State.

Sep 11, 2024

Genomic pioneers collaborate to access the inaccessible

A new experimental method allows researchers to dissect how certain proteins, called pioneer factors, can bind to selective regions of the genome that are inaccessible to other DNA binding proteins.

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Aug 23, 2024

Honey bees may play role in spreading viruses to wild bumble bees

Honey bees may play a role in increasing virus levels in wild bumble bees each spring, according to researchers at Penn State who analyzed seasonal trends of parasite and virus transmission in bees.

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Aug 06, 2024

$3.8M NIH grant funds 3D tissue and organism visualization project

Keith Cheng, distinguished professor of pathology, of pharmacology and of biochemistry and molecular biology at the Penn State College of Medicine, has been awarded a four-year, $3.8 million grant from the National Institutes of Health to further develop novel methods for 3D tissue imaging.

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Aug 02, 2024

Penn State researchers receive USDA-NIFA grant to study male cattle genetics

The U.S. Department of Agriculture (USDA) has awarded a grant to a team of researchers in the Penn State College of Agricultural Sciences to study the genetic mechanisms underlying the development of the testis, the male organ that produces reproductive cells, in cattle and its role in sperm production.

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Aug 01, 2024

How duplicated genomes helped grasses diversify and thrive

Grasses cover about 40% of the Earth’s land surface, thriving in a multitude of environments. The evolutionary success of this plant family, which includes rice, maize, wheat and bamboo, likely results from a history of whole-genome duplications, according to a new analysis led by Penn State biologists.

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Jul 31, 2024

Genes or environment? A new model for understanding disease risk factors

A new model more accurately predicts how genetics and air pollution levels causally influence disease development; may help better assess disease risk and intervention strategies.

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