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New research lends insight into the regulatory control of gene expression in the deadliest of the malaria parasites, Plasmodium falciparum, and provides opportunities for the development of new therapeutic approaches against the disease. PfSnf2L, in red, is an essential malaria parasite protein for developing from the asexual ring to the sexual transmission stage — shown at top with the arrow illustrating the trajectory of various stages of sexual development. When the PfSnf2L enzyme is inhibited by the small molecule, NH125, in green, this leads to disordered DNA packaging. Changes in DNA packaging with active — the white line — and inactive PfSnf2L enzyme — the blue line — are depicted. When the DNA packaging is disrupted, the necessary information for parasite development can no longer be read out and the malaria parasites die thereby blocking transmission. Credit: Längst and Kannan Venugopal/Marti laboratory. All Rights Reserved.

Feb 20, 2025

Disrupting parasite gene regulation reveals new malaria intervention strategy

Malaria's deadliest parasite relies on precise gene regulation to survive. A new multinational study, including Penn State scientists, reveals key insights into these control mechanisms.

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Thomas Gould and Carlos Novoa in Gould's laboratory at Penn State University Park. Credit: Dennis Maney / Penn State. Creative Commons

Feb 20, 2025

Young adults may be more vulnerable to nicotine addiction than the middle aged

People in their late teens and early 20s may be more sensitive to nicotine and more susceptible to nicotine addiction than middle aged adults, according to a new study in mice from researchers in the Penn State Department of Biobehavioral Health.

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Feb 13, 2025

Team Dynamics course to be available for Huck graduate students in Fall 2025

A unique team-building and leadership course, taught by faculty from the Smeal College of Business MBA program, is available for a limited number of Huck graduate students next fall.

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“Tres Comunidades, Un Rio: Life within Peru’s urban Amazonian floodplains" showcases photography, community drawings and research data to portray the relocation, biodiversity, One Health perspective, connections to nature and the overall strength of three floating and stilted communities along the Amazon River in Iquitos, Peru. Credit: Gemina Garland-Lewis. All Rights Reserved.

Feb 12, 2025

Stuckeman School exhibition to showcase urban floodplain communities in Peru

The international traveling exhibition will run from Feb. 17 to March 4 in the Borland Project Space at 125 Borland Building Penn State University Park.

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2024 My Green Lab Consultants Zaman Ataie and Ananya Gollakota check the expiration date on a chemical bottle. Credit: Lydia Vandenbergh. All Rights Reserved.

Feb 11, 2025

Sustainable Labs Program increases participant engagement, welcomes new labs

Two upcoming virtual sessions will cover how labs can learn more and join next year’s cohort.

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Many commercial biological age tests collect genetic information through saliva samples or oral swabs. For accurate measurements, however, blood samples are typically necessary according to a new study led by researchers in the Penn State Department of Biobehavioral Health. Credit: dusanpetkovic/Getty Images. All Rights Reserved.

Feb 06, 2025

Understanding aging requires more than counting birthdays

Types of tissue samples matter when measuring a person’s biological age, or how well their body is functioning, researchers report.

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A new biomaterial developed by Penn State engineers mimics a key building block of human tissue, extracellular matrices, which act like scaffolding and enable cells to heal after damage. Credit: Sheikhi Research Group/Penn State. All Rights Reserved.

Feb 04, 2025

Novel ‘living’ biomaterial aims to advance regenerative medicine

A biomaterial that can mimic certain behaviors within biological tissues could advance regenerative medicine, disease modeling, soft robotics and more, according to researchers at Penn State.

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Director Bruce Logan, fourth from left, stands with the IEE Research Award winners. From left to right are: Hong Wu, Lisa Emili, Nathaniel Warner, Brian Fronk and Margaret Busse. Lauren McPhillips is not pictured. Credit: Brenna Buck. All Rights Reserved.

Jan 28, 2025

Researchers recognized for excellence by Institute of Energy and the Environment

The Institute of Energy and the Environment recognized six Penn State faculty members for their research excellence.

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The findings are a step in identifying beneficial microorganisms that potentially could be used to improve mushroom harvests and prevent disease, the researchers said. Credit: Harshal S. Hirve/Unsplash. All Rights Reserved.

Jan 27, 2025

Harnessing mushroom microbiomes for better crop development

Microorganisms collected from the material in which button mushrooms are grown may benefit the development of future fungi crops, according to a study led by researchers in Penn State’s College of Agricultural Sciences and published in the journal Fungal Biology.

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Yongsoo Kim, associate professor of neural and behavioral sciences at the Penn State College of Medicine, is leading a new five-year, $17.9 million grant from the National Institutes of Health's National Institute of Mental Health. Credit: Jason Plotkin / Penn State. Creative Commons

Jan 23, 2025

$17.9M NIH grant to research neurodevelopment disorders

Illuminating key biological pathways that underlie neurodevelopmental and psychiatric disorders, such as autism spectrum disorder and attention deficit hyperactivity disorder, is the goal of a new five-year, $17.9 million grant from the National Institutes of Health’s National Institute of Mental Health to a national team of researchers.

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