News

Engineers model mutations causing drug resistance

Whether it is a drug-resistant strain of bacteria, or cancer cells that no longer react to the drugs intended to kill them, diverse mutations make cells resistant to chemicals, and "second generation" approaches are needed. Now, a team of Penn State engineers may have a way to predict which mutations will occur in people, creating an easier path to create effective pharmaceuticals.

Developing a novel oral antibiotic to treat multidrug-resistant gonorrhea

Up to $2.86M has been awarded to a research team including Penn State scientists to develop a new oral antibiotic to treat multidrug-resistant gonorrhea, a sexually transmitted disease caused by bacteria that have developed resistance to all but one existing antibiotic.

Gene regulatory factors enable bacteria to kill rivals and establish symbiosis

Two factors that control the expression of a key gene required by luminescent bacteria to kill competing bacterial cells have been identified. The finding, by researchers at Penn State, sheds light on the molecular mechanisms that enable different strains of bacteria to compete and establish symbiosis in the Hawaiian bobtail squid.

In the Metabolomics Core Facility, vials filled with extracts of bodily fluid wait in an auto-sampler. Each sample will be passed through a chromatography system that sorts the complex sample into its constituents. Droplets of the separated sample are then misted into the mass spectrometer for analysis.IMAGE: PATRICK MANSELL

Listening to your gut: A powerful new tool on the microbiome and cell metabolism

Many aspects of our lives — not only the presence or absence of certain diseases, but conditions like obesity, sleep patterns, even mood — may be determined, to a surprising extent, by the microbes living inside of us.

Herringbone pattern in plant cell walls critical to cell growth

Plant cells tend to grow longer instead of wider due to the alignment of the many layers of cellulose that make up their cell walls, according to a new study that may have implications for biofuels research.

Academia-enterprise partnership aims to help people with diabetes

Innovative wound dressing would help reduce life-threatening infections, amputations for diabetic patients.

Zhang receives National Science Foundation CAREER Award

Xin Zhang, Paul Berg Early Career Professor of Chemistry and of Biochemistry and of Molecular Biology, has been honored with a Faculty Early Career Development (CAREER) award from the National Science Foundation in recognition of his work to “quantify cellular proteome stress and recovery using chemical methods.”

Persistent environmental contaminant changes the gut microbiome of mice

An industrial chemical — phased out since 2002, but previously used in stain and water-repellent products and firefighting foam — alters the gut microbiome of mice and could have implications for human health, according to an international team of researchers.

Penn State Schreyer Scholar and biomedical engineering student Madison Evans has interned in neurosurgical clinical research at the Hospital of the University of Pennsylvania as well as a biotech company and a medical device company.IMAGE: JEFF RICE

Aspiring neurosurgeon mapping cancer-suppressing protein

Madison Evans is a Penn State biomedical engineering major who would like to become a neurosurgeon. Before she heads off to medical school, though, the Schreyer Honors Scholar is part of a research project that could change the way her future patients receive treatment.

Penn State researcher receives a Rising Star Award in biomedical engineering

Xiaojun “Lance” Lian, assistant professor of biomedical engineering at Penn State, has been named one of the 2020 Rising Star Award recipients in stem cell engineering by the Biomedical Engineering Society’s (BMES) Cellular and Molecular Bioengineering Special Interest Group (CMBE SIG).