Scott Lindner
Associate Professor of Biochemistry & Molecular Biology, Co-Director, Center for Malaria Research
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W230B Millennium Science Complex
University Park, PA 16802 - He/Him
- sel27@psu.edu
- (814) 867-4062
Research Summary
Our laboratory couples molecular parasitology and structural biology to study the malaria parasite (Plasmodium spp.).
Huck Graduate Students
Huck Affiliations
- Center for Infectious Disease Dynamics
- Molecular, Cellular, and Integrative Biosciences
- Center for RNA Molecular Biology
- Center for Malaria Research
- Center for Structural Biology
Links
Publication Tags
These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.
Parasites Malaria Proteins Plasmodium Sporozoites Liver Proteomics Salivary Glands Plasmodium Vivax Rna Binding Proteins Proteome Genes Plasmodium Falciparum Infections Plasmodium Yoelii Clustered Regularly Interspaced Short Palindromic Repeats Messenger Rna Infection Protein Antimalarials Pantoprazole Antimalarial Membrane Proteins Membranes TranscriptomeMost Recent Publications
Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model
Devanshi R. Patel, Allen M. Minns, Derek G. Sim, Cassandra J. Field, Abigail E. Kerr, Talia A. Heinly, Erin Luley, Randall M. Rossi, Carol M. Bator, Ibrahim M. Moustafa, Elizabeth B. Norton, Susan Hafenstein, Scott E. Lindner, Troy C. Sutton, 2024, Microbiology spectrum
Long-read genome assembly and gene model annotations for the rodent malaria parasite Plasmodium yoelii 17XNL
Mitchell J. Godin, Aswathy Sebastian, Istvan Albert, Scott E. Lindner, 2023, Journal of Biological Chemistry
Ribosome heterogeneity and specialization of Plasmodium parasites
James P. McGee, Jean Paul Armache, Scott E. Lindner, 2023, PLoS Pathogens
Comparative proteomics of vesicles essential for the egress of Plasmodium falciparum gametocytes from red blood cells
Juliane Sassmannshausen, Sandra Bennink, Ute Distler, Juliane Küchenhoff, Allen M. Minns, Scott E. Lindner, Paul Christian Burda, Stefan Tenzer, Tim W. Gilberger, Gabriele Pradel, 2023, Molecular Microbiology
Identification of basal complex protein that is essential for maturation of transmission-stage malaria parasites
Rebecca L. Clements, Alexander A. Morano, Francesca M. Navarro, James P. McGee, Esrah W. Du, Vincent A. Streva, Scott E. Lindner, Jeffrey D. Dvorin, 2022, Proceedings of the National Academy of Sciences of the United States of America
Mitochondrially targeted proximity biotinylation and proteomic analysis in Plasmodium falciparum
Ian M. Lamb, Kelly T. Rios, Anurag Shukla, Avantika I. Ahiya, Joanne Morrisey, Joshua C. Mell, Scott E. Lindner, Michael W. Mather, Akhil B. Vaidya, 2022, PLoS One
Direct type I interferon signaling in hepatocytes controls malaria
Camila Marques-da-Silva, Kristen Peissig, Michael P. Walker, Justine Shiau, Carson Bowers, Dennis E. Kyle, Rahul Vijay, Scott E. Lindner, Samarchith P. Kurup, 2022, Cell Reports
Standard Selection Treatments with Sulfadiazine Limit Plasmodium yoelii Host-to-Vector Transmission
Kelly T. Rios, Taylor M. Dickson, Scott E. Lindner, 2022, mSphere
Addendum: Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites
Scott Lindner, K Swearingen, M Shears, A Sebastian, M Walker, E Vrana, K Hart, A Minns, Istvan Albert, P Sinnis, R Moritz, Stefan H.I. Kappe, Kappe SHI, 2022, Nature Communications on p. 283
Physical compatibility of Normosol-R with critical care medications used in patients with COVID-19 during simulated Y-site administration
Amanda A. Holyk, Alexandra H. Lindner, Scott E. Lindner, Brian W. Shippert, 2022, Bulletin. American Society of Hospital Pharmacists on p. E27-E33
Most-Cited Papers
Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice
Sebastian A. Mikolajczak, Ashley M. Vaughan, Niwat Kangwanrangsan, Wanlapa Roobsoong, Matthew Fishbaugher, Narathatai Yimamnuaychok, Nastaran Rezakhani, Viswanathan Lakshmanan, Naresh Singh, Alexis Kaushansky, Nelly Camargo, Michael Baldwin, Scott E. Lindner, John H. Adams, Jetsumon Sattabongkot, Stefan H.I. Kappe, 2015, Cell Host and Microbe on p. 526-535
Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics
Kristian E. Swearingen, Scott E. Lindner, Lirong Shi, Melanie J. Shears, Anke Harupa, Christine S. Hopp, Ashley M. Vaughan, Timothy A. Springer, Robert L. Moritz, Stefan H.I. Kappe, Photini Sinnis, 2016, PLoS Pathogens
Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites
Scott E. Lindner, Kristian E. Swearingen, Melanie J. Shears, Michael P. Walker, Erin N. Vrana, Kevin J. Hart, Allen M. Minns, Photini Sinnis, Robert L. Moritz, Stefan H.I. Kappe, 2019, Nature Communications
Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodium vivax salivary gland sporozoites
Kristian E. Swearingen, Scott E. Lindner, Erika L. Flannery, Ashley M. Vaughan, Robert D. Morrison, Rapatbhorn Patrapuvich, Cristian Koepfli, Ivo Muller, Aaron Jex, Robert L. Moritz, Stefan H.I. Kappe, Jetsumon Sattabongkot, Sebastian A. Mikolajczak, 2017, PLoS Neglected Tropical Diseases
A bioinformatic survey of RNA-binding proteins in Plasmodium
BP Niranjan Reddy, Sony Shrestha, Kevin J. Hart, Xiaoying Liang, Karen Kemirembe, Liwang Cui, Scott E. Lindner, 2015, BMC Genomics
Translational regulation during stage transitions in malaria parasites
Liwang Cui, Scott Lindner, Jun Miao, 2015, Annals of the New York Academy of Sciences on p. 1-9
Th1-like Plasmodium-Specific Memory CD4<sup>+</sup> T Cells Support Humoral Immunity
Ryan A. Zander, Rahul Vijay, Angela D. Pack, Jenna J. Guthmiller, Amy C. Graham, Scott E. Lindner, Ashley M. Vaughan, Stefan H.I. Kappe, Noah S. Butler, 2017, Cell Reports on p. 1839-1852
Enzymes involved in plastid-targeted phosphatidic acid synthesis are essential for Plasmodium yoelii liver-stage development
Scott E. Lindner, Mark J. Sartain, Kiera Hayes, Anke Harupa, Robert L. Moritz, Stefan H.I. Kappe, Ashley M. Vaughan, 2014, Molecular Microbiology on p. 679-693
Cutting back malaria: CRISPR/Cas9 genome editing of Plasmodium
Marcus C.S. Lee, Scott E. Lindner, Jose Juan Lopez-Rubio, Manuel Llinás, 2019, Briefings in Functional Genomics and Proteomics on p. 281-289
Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malaria
Ivo Muller, Aaron R. Jex, Stefan H.I. Kappe, Sebastian A. Mikolajczak, Jetsumon Sattabongkot, Rapatbhorn Patrapuvich, Scott Lindner, Erika L. Flannery, Cristian Koepfli, Brendan Ansell, Anita Lerch, Samantha J. Emery-Corbin, Sarah Charnaud, Jeffrey Smith, Nicolas Merrienne, Kristian E. Swearingen, Robert L. Moritz, Michaela Petter, Michael F. Duffy, Vorada Chuenchob, 2019, International Journal for Parasitology on p. 501-513
News Articles Featuring Scott Lindner
Apr 15, 2024
Huck Leadership Fellows selected for 2024-25
For the 2024-2025 academic year, Huck Institutes of the Life Sciences has appointed Associate Professor of Biomedical Engineering Scott Medina, Professor of Statistics Lingzhou Xue, and Associate Professor of Surgery Dino Ravnic to be Huck Leadership Fellows.
Full Article
Mar 12, 2024
New nasal vaccine platform helps clear COVID-19 infections in an animal model
A newly developed intranasal vaccine candidate helps to clear COVID-19 infections more quickly than controls in pre-clinical testing, according to a recent study.
Full Article
Jun 26, 2023
Neela Yennawar and Scott Lindner selected as 2023 Huck Leadership Fellows
Launched in 2022, the Huck Leadership Fellows Program was developed for faculty members seeking to sharpen their leadership skills with an opportunity for exposure to senior leadership within the interdisciplinary research unit.
Full Article
Feb 25, 2021
Study finds short window for donating convalescent plasma to COVID-19 patients
The optimal timeframe for donating convalescent plasma for use in COVID-19 immunotherapy, which was given emergency-use authorization by the Food and Drug Administration in August 2020, is within 60 days of the onset of symptoms, according to a new Penn State-led study.
Full Article
Feb 25, 2021
Study finds short window for donating convalescent plasma to COVID-19 patients
The optimal timeframe for donating convalescent plasma for use in COVID-19 immunotherapy, which was given emergency use authorization by the Food and Drug Administration in August 2020, is within 60 days of the onset of symptoms, according to a new study. The research also reveals that the ideal convalescent plasma donor is a recovered COVID-19 patient who is older than 30 and whose illness had been severe.
Full Article
Oct 31, 2019
Malaria parasite lives on the edge
The parasite that causes malaria expresses genes that code for the proteins it will need in later life stages, using two separate schemes to prevent these proteins from actually being made until they are needed, according to new research.
Full Article
Jan 31, 2019
Male birth control for the malaria parasite
Full Article