Scott Lindner

Associate Professor of Biochemistry & Molecular Biology, Co-Director, Center for Malaria Research

Scott Lindner

Research Summary

Our laboratory couples molecular parasitology and structural biology to study the malaria parasite (Plasmodium spp.).

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Parasites Malaria Sporozoites Plasmodium Proteomics Proteins Liver Genes Salivary Glands Infection Infections Proteome Rodentia Culicidae Clustered Regularly Interspaced Short Palindromic Repeats Protein Plasmodium Yoelii Neutralizing Antibodies Gene Editing Viruses Plasmodium Falciparum Life Cycle Stages Plasmodium Vivax Catalytic Rna Immunotherapy

Most Recent Papers

Addendum

Scott E. Lindner, Kristian E. Swearingen, Melanie J. Shears, Aswathy Sebastian, Michael P. Walker, Erin N. Vrana, Kevin J. Hart, Allen M. Minns, Istvan Albert, Photini Sinnis, Robert L. Moritz, Stefan H.I. Kappe, 2022, Nature Communications on p. 283

Physical compatibility of Normosol-R with critical care medications used in patients with COVID-19 during simulated Y-site administration

Amanda A. Holyk, Alexandra H. Lindner, Scott E. Lindner, Brian W. Shippert, 2022, Bulletin. American Society of Hospital Pharmacists on p. e27-e33

Limited window for donation of convalescent plasma with high live-virus neutralizing antibody titers for COVID-19 immunotherapy

Abhinay Gontu, Sreenidhi Srinivasan, Eric Salazar, Meera Surendran Nair, Ruth H. Nissly, Denver Greenawalt, Ian M. Bird, Catherine M. Herzog, Matthew J. Ferrari, Indira Poojary, Robab Katani, Scott E. Lindner, Allen M. Minns, Randall Rossi, Paul A. Christensen, Brian Castillo, Jian Chen, Todd N. Eagar, Xin Yi, Picheng Zhao, Christopher Leveque, Randall J. Olsen, David W. Bernard, Jimmy Gollihar, Suresh V. Kuchipudi, James M. Musser, Vivek Kapur, 2021, Communications Biology

The Plasmodium NOT1-G paralogue is an essential regulator of sexual stage maturation and parasite transmission

Kevin J. Hart, B. Joanne Power, Kelly T. Rios, Aswathy Sebastian, Scott E. Lindner, 2021, PLoS Biology

Physical compatibility of Normosol-R with critical care medications used in patients with COVID-19 during simulated Y-site administration

Amanda Holyk, Alexandra Lindner, Scott Lindner, Brian Shippert, 2021, American Journal of Health-System Pharmacy

Definition of constitutive and stage-enriched promoters in the rodent malaria parasite, Plasmodium yoelii

Laura M. Bowman, Logan E. Finger, Kevin J. Hart, Scott E. Lindner, 2020, Malaria Journal

Determination of human identity from Anopheles stephensi mosquito blood meals using direct amplification and massively parallel sequencing

Shayna L. Gray, Teresa M. Tiedge, Joann M. Butkus, Tyler J. Earp, Scott E. Lindner, Reena Roy, 2020, Forensic Science International: Genetics

Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

Scott E. Lindner, Kristian E. Swearingen, Melanie J. Shears, Michael P. Walker, Erin N. Vrana, Kevin J. Hart, Allen M. Minns, Photini Sinnis, Robert L. Moritz, Stefan H.I. Kappe, 2019, Nature Communications

Cutting back malaria: CRISPR/Cas9 genome editing of plasmodium

Marcus C.S. Lee, Scott E. Lindner, Jose Juan Lopez-Rubio, Manuel Llinás, 2019, Briefings in Functional Genomics and Proteomics on p. 281-289

Ribozyme-mediated, multiplex CRISPR gene editing and CRISPR interference (CRISPRi) in rodent-infectious Plasmodium yoelii

Michael P. Walker, Scott E. Lindner, 2019, Journal of Biological Chemistry on p. 9555-9566

Most-Cited Papers

Total and putative surface proteomics of malaria parasite salivary gland sporozoites

Scott E. Lindner, Kristian E. Swearingen, Anke Harupa, Ashley M. Vaughan, Photini Sinnis, Robert L. Moritz, Stefan H.I. Kappe, 2013, Molecular and Cellular Proteomics on p. 1127-1143

Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice

Sebastian A. Mikolajczak, Ashley M. Vaughan, Niwat Kangwanrangsan, Wanlapa Roobsoong, Matthew Fishbaugher, Narathatai Yimamnuaychok, Nastaran Rezakhani, Viswanathan Lakshmanan, Naresh Singh, Alexis Kaushansky, Nelly Camargo, Michael Baldwin, Scott E. Lindner, John H. Adams, Jetsumon Sattabongkot, Stefan H.I. Kappe, 2015, Cell Host and Microbe on p. 526-535

Interrogating the Plasmodium Sporozoite Surface

Kristian E. Swearingen, Scott E. Lindner, Lirong Shi, Melanie J. Shears, Anke Harupa, Christine S. Hopp, Ashley M. Vaughan, Timothy A. Springer, Robert L. Moritz, Stefan H.I. Kappe, Photini Sinnis, 2016, PLoS Pathogens

A rapid and scalable density gradient purification method for Plasmodium sporozoites

Mark Kennedy, Matthew E. Fishbaugher, Ashley M. Vaughan, Rapatbhorn Patrapuvich, Rachasak Boonhok, Narathatai Yimamnuaychok, Nastaran Rezakhani, Peter Metzger, Marisa Ponpuak, Jetsumon Sattabongkot, Stefan H. Kappe, Jen Cc Hume, Scott E. Lindner, 2012, Malaria Journal

Malaria parasite pre-erythrocytic infection: Preparation meets opportunity

Scott E. Lindner, Jessica L. Miller, Stefan H.I. Kappe, 2012, Cellular Microbiology on p. 316-324

Perturbations of PlasmodiumPuf2 expression and RNA-seq of Puf2-deficient sporozoites reveal a critical role in maintaining RNA homeostasis and parasite transmissibility

Scott E. Lindner, Sebastian A. Mikolajczak, Ashley M. Vaughan, Wonjong Moon, Brad R. Joyce, William J. Sullivan, Stefan H.I. Kappe, 2013, Cellular Microbiology on p. 1266-1283

A transgenic Plasmodium falciparum NF54 strain that expresses GFP-luciferase throughout the parasite life cycle

Ashley M. Vaughan, Sebastian A. Mikolajczak, Nelly Camargo, Viswanathan Lakshmanan, Mark Kennedy, Scott E. Lindner, Jessica L. Miller, Jen C.C. Hume, Stefan H.I. Kappe, 2012, Molecular and Biochemical Parasitology on p. 143-147

Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

Scott E. Lindner, Kristian E. Swearingen, Melanie J. Shears, Michael P. Walker, Erin N. Vrana, Kevin J. Hart, Allen M. Minns, Photini Sinnis, Robert L. Moritz, Stefan H.I. Kappe, 2019, Nature Communications

A bioinformatic survey of RNA-binding proteins in Plasmodium

BP Niranjan Reddy, Sony Shrestha, Kevin J. Hart, Xiaoying Liang, Karen Kemirembe, Liwang Cui, Scott E. Lindner, 2015, BMC Genomics

Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodium vivax salivary gland sporozoites

Kristian E. Swearingen, Scott E. Lindner, Erika L. Flannery, Ashley M. Vaughan, Robert D. Morrison, Rapatbhorn Patrapuvich, Cristian Koepfli, Ivo Muller, Aaron Jex, Robert L. Moritz, Stefan H.I. Kappe, Jetsumon Sattabongkot, Sebastian A. Mikolajczak, 2017, PLoS Neglected Tropical Diseases