Manuel Llinas

Distinguished Professor of Biochemistry and Molecular Biology

Manuel Llinas

Research Summary

Understanding the molecular mechanisms of gene regulation and metabolism in the malaria parasite Plasmodium falciparum using functional genomics and metabolomics.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

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Parasites Plasmodium Falciparum Malaria Antimalarials Plasmodium Genes Pharmaceutical Preparations Sexual Development Dna Binding Proteins Life Cycle Stages Drugs Proteins Culicidae Mutation Metabolism Genome Piperaquine Artesunate Virulence Tricarboxylic Acids Glutathione Transferase Therapeutics In Vitro Techniques Antimalarial Blood

Most Recent Publications

Laura M. Hagenah, Satish K. Dhingra, Jennifer L. Small-Saunders, Tarrick Qahash, Andreas Willems, Kyra A. Schindler, Gabriel W. Rangel, Eva Gil-Iturbe, Jonathan Kim, Emiliya Akhundova, Tomas Yeo, John Okombo, Filippo Mancia, Matthias Quick, Paul D. Roepe, Manuel Llinás, David A. Fidock, 2024, mBio on p. e0183223

Sethu C. Nair, Justin T. Munro, Alexis Mann, Manuel Llinás, Sean T. Prigge, 2023, Proceedings of the National Academy of Sciences of the United States of America

Eva S. Istvan, Francisco Guerra, Matthew Abraham, Kuo Sen Huang, Frances Rocamora, Haoshuang Zhao, Lan Xu, Charisse Pasaje, Krittikorn Kumpornsin, Madeline R. Luth, Haissi Cui, Tuo Yang, Sara Palomo Diaz, Maria G. Gomez-Lorenzo, Tarrick Qahash, Nimisha Mittal, Sabine Ottilie, Jacquin Niles, Marcus C.S. Lee, Manuel Llinas, Nobutaka Kato, John Okombo, David A. Fidock, Paul Schimmel, Francisco Javier Gamo, Daniel E. Goldberg, Elizabeth A. Winzeler, 2023, Science Translational Medicine

Joshua H. Butler, Heather J. Painter, Emily K. Bremers, Priscilla Krai, Manuel Llinás, Maria B. Cassera, 2023, Molecules

Gloria Meredith, G Komazin, A Rizk, K Armbruster, V Bonnell, Manuel Llinas, Manuel Llinás, Timothy Meredith, 2023, Journal of Bacteriology on p. e0039022

Laura E. de Vries, Patrick A.M. Jansen, Catalina Barcelo, Justin Munro, Julie M.J. Verhoef, Charisse Flerida A. Pasaje, Kelly Rubiano, Josefine Striepen, Nada Abla, Luuk Berning, Judith M. Bolscher, Claudia Demarta-Gatsi, Rob W.M. Henderson, Tonnie Huijs, Karin M.J. Koolen, Patrick K. Tumwebaze, Tomas Yeo, Anna C.C. Aguiar, Iñigo Angulo-Barturen, Alisje Churchyard, Jake Baum, Benigno Crespo Fernández, Aline Fuchs, Francisco Javier Gamo, Rafael V.C. Guido, María Belén Jiménez-Diaz, Dhelio B. Pereira, Rosemary Rochford, Camille Roesch, Laura M. Sanz, Graham Trevitt, Benoit Witkowski, Sergio Wittlin, Roland A. Cooper, Philip J. Rosenthal, Robert W. Sauerwein, Joost Schalkwijk, Pedro H.H. Hermkens, Roger V. Bonnert, Brice Campo, David A. Fidock, Manuel Llinás, Jacquin C. Niles, Taco W.A. Kooij, Koen J. Dechering, 2022, Nature Communications

Lauren B. Arendse, James M. Murithi, Tarrick Qahash, Charisse Flerida A. Pasaje, Luiz C. Godoy, Sumanta Dey, Liezl Gibhard, Sonja Ghidelli-Disse, Gerard Drewes, Marcus Bantscheff, Maria J. Lafuente-Monasterio, Stephen Fienberg, Lynn Wambua, Samuel Gachuhi, Dina Coertzen, Mariëtte van der Watt, Janette Reader, Ayesha S. Aswat, Erica Erlank, Nelius Venter, Nimisha Mittal, Madeline R. Luth, Sabine Ottilie, Elizabeth A. Winzeler, Lizette L. Koekemoer, Lyn Marie Birkholtz, Jacquin C. Niles, Manuel Llinás, David A. Fidock, Kelly Chibale, 2022, Science Translational Medicine

Carolina M. Andrade, Hannah Fleckenstein, Richard Thomson-Luque, Safiatou Doumbo, Nathalia F. Lima, Carrie Anderson, Julia Hibbert, Christine S. Hopp, Tuan M. Tran, Shanping Li, Moussa Niangaly, Hamidou Cisse, Didier Doumtabe, Jeff Skinner, Dan Sturdevant, Stacy Ricklefs, Kimmo Virtaneva, Muhammad Asghar, Manijeh Vafa Homann, Louise Turner, Joana Martins, Erik L. Allman, Marie Esther N’Dri, Volker Winkler, Manuel Llinás, Catherine Lavazec, Craig Martens, Anna Färnert, Kassoum Kayentao, Aissata Ongoiba, Thomas Lavstsen, Nuno S. Osório, Thomas D. Otto, Mario Recker, Boubacar Traore, Peter D. Crompton, Silvia Portugal, 2022, Nature Medicine on p. 2216

J Okombo, S Mok, T Qahash, T Yeo, J Bath, L Orchard, E Owens, Imhoi Koo, Istvan Albert, Manuel Llinás, D Fidock, 2022, PLoS Pathogens on p. e1010926

Timothy James Russell, Erandi K. De Silva, Valerie M. Crowley, Kathryn Shaw-Saliba, Namita Dube, Gabrielle Josling, Charisse Flerida A. Pasaje, Irene Kouskoumvekaki, Gianni Panagiotou, Jacquin C. Niles, Marcelo Jacobs-Lorena, C. Denise Okafor, Francisco Javier Gamo, Manuel Llinás, 2022, PLoS Pathogens

Most-Cited Papers

Björn F.C. Kafsack, Núria Rovira-Graells, Taane G. Clark, Cristina Bancells, Valerie M. Crowley, Susana G. Campino, April E. Williams, Laura G. Drought, Dominic P. Kwiatkowski, David A. Baker, Alfred Cortés, Manuel Llinás, 2014, Nature on p. 248-252

Abhinav Sinha, Katie R. Hughes, Katarzyna K. Modrzynska, Thomas D. Otto, Claudia Pfander, Nicholas J. Dickens, Agnieszka A. Religa, Ellen Bushell, Anne L. Graham, Rachael Cameron, Bjorn F.C. Kafsack, April E. Williams, Manuel Llinás, Matthew Berriman, Oliver Billker, Andrew P. Waters, 2014, Nature on p. 253-257

Wesley C. Van Voorhis, John H. Adams, Roberto Adelfio, Vida Ahyong, Myles H. Akabas, Pietro Alano, Aintzane Alday, Yesmalie Alemán Resto, Aishah Alsibaee, Ainhoa Alzualde, Katherine T. Andrews, Simon V. Avery, Vicky M. Avery, Lawrence Ayong, Mark Baker, Stephen Baker, Choukri Ben Mamoun, Sangeeta Bhatia, Quentin Bickle, Lotfi Bounaadja, Tana Bowling, Jürgen Bosch, Lauren E. Boucher, Fabrice F. Boyom, Jose Brea, Marian Brennan, Audrey Burton, Conor R. Caffrey, Grazia Camarda, Manuela Carrasquilla, Dee Carter, Maria Belen Cassera, Ken Chih-Chien Cheng, Worathad Chindaudomsate, Anthony Chubb, Beatrice L. Colon, Daisy D. Colón-López, Yolanda Corbett, Gregory J. Crowther, Noemi Cowan, Sarah D’Alessandro, Na Le Dang, Michael Delves, Joseph L. DeRisi, Alan Y. Du, Sandra Duffy, Shimaa Abd El-Salam El-Sayed, Michael T. Ferdig, José A. Fernández Robledo, David A. Fidock, Isabelle Florent, Patrick V.T. Fokou, Ani Galstian, Francisco Javier Gamo, Suzanne Gokool, Ben Gold, Todd Golub, Gregory M. Goldgof, Rajarshi Guha, W. Armand Guiguemde, Nil Gural, R. Kiplin Guy, Michael A.E. Hansen, Kirsten K. Hanson, Andrew Hemphill, Rob Hooft van Huijsduijnen, Takaaki Horii, Paul Horrocks, Tyler B. Hughes, Christopher Huston, Ikuo Igarashi, Katrin Ingram-Sieber, Maurice A. Itoe, Ajit Jadhav, Amornrat Naranuntarat Jensen, Laran T. Jensen, Rays H.Y. Jiang, Annette Kaiser, Jennifer Keiser, Thomas Ketas, Sebastien Kicka, Sunyoung Kim, Kiaran Kirk, Vidya P. Kumar, Dennis E. Kyle, Maria Jose Lafuente, Scott Landfear, Nathan Lee, Sukjun Lee, Adele M. Lehane, Fengwu Li, David Little, Liqiong Liu, Manuel Llinás, Maria I. Loza, Aristea Lubar, Leonardo Lucantoni, Isabelle Lucet, Louis Maes, Dalu Mancama, Nuha R. Mansour, Sandra March, Sheena McGowan, Iset Medina Vera, Stephan Meister, Luke Mercer, Jordi Mestres, Alvine N. Mfopa, Raj N. Misra, Seunghyun Moon, John P. Moore, Francielly Morais Rodrigues da Costa, Joachim Müller, Arantza Muriana, Stephen Nakazawa Hewitt, Bakela Nare, Carl Nathan, Nathalie Narraidoo, Sujeevi Nawaratna, Kayode K. Ojo, Diana Ortiz, Gordana Panic, George Papadatos, Silvia Parapini, Kailash Patra, Ngoc Pham, Sarah Prats, David M. Plouffe, Sally Ann Poulsen, Anupam Pradhan, Celia Quevedo, Ronald J. Quinn, Christopher A. Rice, Mohamed Abdo Rizk, Andrea Ruecker, Robert St. Onge, Rafaela Salgado Ferreira, Jasmeet Samra, Natalie G. Robinett, Ulrich Schlecht, Marjorie Schmitt, Filipe Silva Villela, Francesco Silvestrini, Robert Sinden, Dennis A. Smith, Thierry Soldati, Andreas Spitzmüller, Serge Maximilian Stamm, David J. Sullivan, William Sullivan, Sundari Suresh, Brian M. Suzuki, Yo Suzuki, S. Joshua Swamidass, Donatella Taramelli, Lauve R.Y. Tchokouaha, Anjo Theron, David Thomas, Kathryn F. Tonissen, Simon Townson, Abhai K. Tripathi, Valentin Trofimov, Kenneth O. Udenze, Imran Ullah, Cindy Vallieres, Edgar Vigil, Joseph M. Vinetz, Phat Voong Vinh, Hoan Vu, Nao Aki Watanabe, Kate Weatherby, Pamela M. White, Andrew F. Wilks, Elizabeth A. Winzeler, Edward Wojcik, Melanie Wree, Wesley Wu, Naoaki Yokoyama, Paul H.A. Zollo, Nada Abla, Benjamin Blasco, Jeremy Burrows, Benoît Laleu, Didier Leroy, Thomas Spangenberg, Timothy Wells, Paul A. Willis, 2016, PLoS Pathogens

Bradley I. Coleman, Kristen M. Skillman, Rays H.Y. Jiang, Lauren M. Childs, Lindsey M. Altenhofen, Markus Ganter, Yvette Leung, Ilana Goldowitz, Björn F.C. Kafsack, Matthias Marti, Manuel Llinás, Caroline O. Buckee, Manoj T. Duraisingh, 2014, Cell Host and Microbe on p. 177-186

Annie N. Cowell, Eva S. Istvan, Amanda K. Lukens, Maria G. Gomez-Lorenzo, Manu Vanaerschot, Tomoyo Sakata-Kato, Erika L. Flannery, Pamela Magistrado, Edward Owen, Matthew Abraham, Gregory La Monte, Heather J. Painter, Roy M. Williams, Virginia Franco, Maria Linares, Ignacio Arriaga, Selina Bopp, Victoria C. Corey, Nina F. Gnädig, Olivia Coburn-Flynn, Christin Reimer, Purva Gupta, James M. Murithi, Pedro A. Moura, Olivia Fuchs, Erika Sasaki, Sang W. Kim, Christine H. Teng, Lawrence T. Wang, Asl Akidil, Sophie Adjalley, Paul A. Willis, Dionicio Siegel, Olga Tanaseichuk, Yang Zhong, Yingyao Zhou, Manuel Llinás, Sabine Ottilie, Francisco Javier Gamo, Marcus C.S. Lee, Daniel E. Goldberg, David A. Fidock, Dyann F. Wirth, Elizabeth A. Winzeler, 2018, Science on p. 191-199

Sexual development in Plasmodium parasites: Knowing when it's time to commit

Gabrielle A. Josling, Manuel Llinás, 2015, Nature Reviews Microbiology on p. 573-587

Liliana Mancio-Silva, Ksenija Slavic, Margarida T. Grilo Ruivo, Ana Rita Grosso, Katarzyna K. Modrzynska, Iset Medina Vera, Joana Sales-Dias, Ana Rita Gomes, Cameron Ross Macpherson, Pierre Crozet, Mattia Adamo, Elena Baena-Gonzalez, Rita Tewari, Manuel Llinás, Oliver Billker, Maria M. Mota, 2017, Nature on p. 213-216

Hangjun Ke, Ian A. Lewis, Joanne M. Morrisey, Kyle J. McLean, Suresh M. Ganesan, Heather J. Painter, Michael W. Mather, Marcelo Jacobs-Lorena, Manuel Llinás, Akhil B. Vaidya, 2015, Cell Reports on p. 164-174

Erik L. Allman, Heather J. Painter, Jasmeet Samra, Manuela Carrasquilla, Manuel Llinás, 2016, Antimicrobial Agents and Chemotherapy on p. 6635-6643

Andreas Martin Lisewski, Joel P. Quiros, Caroline L. Ng, Anbu Karani Adikesavan, Kazutoyo Miura, Nagireddy Putluri, Richard T. Eastman, Daniel Scanfeld, Sam J. Regenbogen, Lindsey Altenhofen, Manuel Llinás, Arun Sreekumar, Carole Long, David A. Fidock, Olivier Lichtarge, 2014, Cell on p. 916-928

News Articles Featuring Manuel Llinas

Honors for Booker, Girirajan, Llinás

3 Penn State researchers have received awards and new titles

Manuel Llinás named as the Ernest C. Pollard Professor in Biotechnology

Manuel Llinás, distinguished professor of biochemistry and molecular biology and of chemistry in the Penn State Eberly College of Science, has been named the Ernest C. Pollard Professor in Biotechnology.

Eberly graduate student receives Excellence in Mentoring Award

Victoria “Tori” Bonnell, a doctoral student in biochemistry, microbiology and molecular biology (BMMB), has been selected to receive the Graduate Student Excellence in Mentoring Award by the Penn State Graduate School.

Cancer drug could potentially be used against malaria

A cancer drug currently in clinical trials has shown the potential to protect from, cure, and prevent transmission of malaria. The breakthrough finding by an international team that includes researchers at Penn State offers new hope against a disease that kills over half a million people annually, most severely affecting children under five, pregnant women, and patients with HIV.

Penn State biochemist Manuel Llinás named distinguished professor

Manuel Llinás, professor of biochemistry and molecular biology and of chemistry at Penn State, has been selected to receive the title of distinguished professor of biochemistry and molecular biology in recognition of his exceptional record of teaching, research, and service to the University community.

Malaria parasites hide out in humans when it's not mosquito season

Malaria parasites survive the mosquito-free dry season by waiting silently in humans for the return of the rainy season that brings back with it mosquitoes. New research, by an international team including Penn State scientists, helps explain how the Plasmodium falciparum parasite survives the disruption to its lifecycle, which requires development within the mosquito host for transmission between people.

New tool in fight against malaria

Redesigning molecules originally developed to treat the skin disease psoriasis could lead to an effective new drug against malaria, according to an international team of researchers.