Director of the Center for Structural Oncology; Huck Chair in Molecular Biophysics; Professor of Biomedical Engineering
Engineering new molecular paradigms to create a world without cancer.
Huck Graduate Students
- Molecular, Cellular, and Integrative Biosciences
- Bioinformatics and Genomics
- Center for Structural Oncology
Publication TagsLiquids Electron Microscopy Nanoparticles Proteins Imaging Techniques Cells Protein Liquid Macromolecules Electrons Visualization Electron Microscopes Stem Cells Viruses Vacuum Cryo Electron Microscopy Electron Particle Microfluidics Tomography Neoplasms Transmission Electron Microscopy Tumors Messenger Rna Repair Dna
Most Recent Papers
High-Resolution Imaging of Human Viruses in Liquid Droplets
G. M. Jonaid, William J. Dearnaley, Michael A. Casasanta, Liam Kaylor, Samantha Berry, Madeline J. Dukes, Michael S. Spilman, Jennifer L. Gray, Deborah F. Kelly, 2021, Advanced Materials
Microchip-based structure determination of low-molecular weight proteins using cryo-electron microscopy
Michael A. Casasanta, G. M. Jonaid, Liam Kaylor, William Y. Luqiu, Maria J. Solares, Mariah L. Schroen, William J. Dearnaley, Jarad Wilson, Madeline J. Dukes, Deborah F. Kelly, 2021, Nanoscale on p. 7285-7293
Isolation of Disease-relevant p53 for Cryo-Electron Microscopy Analysis
Deborah Kelly, 2020, Nature Protocol Exchange
Microchip-Based Structure Determination of Disease-Relevant p53
Maria J. Solares, G. M. Jonaid, William Y. Luqiu, Yanping Liang, Madison C. Evans, William J. Dearnaley, Zhi Sheng, Deborah F. Kelly, 2020, Analytical Chemistry
Liquid cell TEM imaging techniques and optimization for biological samples
Madeline Dukes, Deborah Kelly, Cameron Varano, 2020, Microscopy and Microanalysis
Liquid-Cell Electron Tomography of Biological Systems
William J. Dearnaley, Beatrice Schleupner, A. Cameron Varano, Nick A. Alden, Floricel Gonzalez, Michael A. Casasanta, Birgit E. Scharf, Madeline J. Dukes, Deborah F. Kelly, 2019, Nano Letters on p. 6734-6741
Nick A. Alden, A. Cameron Varano, William J. Dearnaley, Maria J. Solares, William Y. Luqiu, Yanping Liang, Zhi Sheng, Sarah M. McDonald, John Damiano, Jennifer McConnell, Madeline J. Dukes, Deborah F. Kelly, 2019, Small on p. 1970109
Cryo-EM Reveals Architectural Diversity in Active Rotavirus Particles
Mary Hauser, William J. Dearnaley, A. Cameron Varano, Michael Casasanta, Sarah M. McDonald, Deborah F. Kelly, 2019, Computational and Structural Biotechnology Journal on p. 1178-1183
Customizable Cryo-EM Chips Improve 3D Analysis of Macromolecules
Varano, A Cameron, Nick Alden, W Dearnaley, Michael Casasanta, John Damiano, Jennifer McConnell, Madeline Dukes, Deborah Kelly, 2019, Microscopy and Microanalysis on p. 1310--1311
Correcting errors in the BRCA1 warning system
Yanping Liang, William J. Dearnaley, Nick A. Alden, Maria J. Solares, Brian L. Gilmore, Kevin J. Pridham, Cameron Varano, Zhi Sheng, Elizabeth Alli, Deb Kelly, 2019, DNA Repair on p. 120-128
A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications
Sujuan Guo, Yanping Liang, Susan F. Murphy, Angela Huang, Haihong Shen, Deborah F. Kelly, Pablo Sobrado, Zhi Sheng, 2015, Autophagy on p. 560-572
Toward design of magnetic nanoparticle clusters stabilized by biocompatible diblock copolymers for T <sub>2</sub>-weighted MRI contrast
Sharavanan Balasubramaniam, Sanem Kayandan, Yin Nian Lin, Deborah F. Kelly, Michael J. House, Robert C. Woodward, Timothy G. St. Pierre, Judy S. Riffle, Richey M. Davis, 2014, Langmuir on p. 1580-1587
Real-Time Visualization of Nanoparticles Interacting with Glioblastoma Stem Cells
Elliot S. Pohlmann, Kaya Patel, Sujuan Guo, Madeline J. Dukes, Zhi Sheng, Deb Kelly, 2015, Nano Letters on p. 2329-2335
Visualizing viral assemblies in a nanoscale biosphere
Brian L. Gilmore, Shannon P. Showalter, Madeline J. Dukes, Justin R. Tanner, Andrew C. Demmert, Sarah M. McDonald, Deborah F. Kelly, 2013, Lab on a Chip - Miniaturisation for Chemistry and Biology on p. 216-219
Survival kinase genes present prognostic significance in glioblastoma
Robin T. Varghese, Yanping Liang, Ting Guan, Christopher T. Franck, Deborah F. Kelly, Zhi Sheng, 2016, Oncotarget on p. 20140-20151
Affinity grid-based cryo-EM of PKC binding to RACK1 on the ribosome
Gyanesh Sharma, Jesper Pallesen, Sanchaita Das, Robert Grassucci, Robert Langlois, Cheri M. Hampton, Deborah F. Kelly, Amedee des Georges, Joachim Frank, 2013, Journal of Structural Biology on p. 190-194
Patient-derived glioblastoma stem cells respond differentially to targeted therapies
Pratik Kanabur, Sujuan Guo, Gary R. Simonds, Deborah F. Kelly, Robert G. Gourdie, Scott S. Verbridge, Zhi Sheng, 2016, Oncotarget on p. 86406-86419
Visualizing virus particle mobility in liquid at the nanoscale
A. Cameron Varano, Amina Rahimi, Madeline J. Dukes, Steven Poelzing, Sarah M. McDonald, Deborah F. Kelly, 2015, Chemical Communications on p. 16176-16179
Prolonged particulate hexavalent chromium exposure suppresses homologous recombination repair in human lung cells
Cynthia L. Browning, Qin Qin, Deborah F. Kelly, Rohit Prakash, Fabio Vanoli, Maria Jasin, John Pierce Wise, 2016, Toxicological Sciences on p. 70-78
Visualizing nanoparticle mobility in liquid at atomic resolution
Madeline J. Dukes, Benjamin W. Jacobs, David G. Morgan, Harshad Hegde, Deborah F. Kelly, 2013, Chemical Communications on p. 3007-3009
News Articles Featuring Deb Kelly
Aug 02, 2021
Researchers Film Human Viruses in Liquid Droplets at Near-atomic Detail
A pond in summer can reveal more about a fish than a pond in winter. The fish living in icy conditions might remain still enough to study its scales, but to understand how the fish swims and behaves, it needs to freely move in three dimensions. The same holds true for analyzing how biological items, such as viruses, move in the human body, according to a research team led by Deb Kelly, Huck Chair in Molecular Biophysics and professor of biomedical engineering at Penn State, who has used advanced electron microscopy (EM) technology to see how human viruses move in high resolution in a near-native environment. The visualization technique could lead to improved understanding of how vaccine candidates and treatments behave and function as they interact with target cells, Kelly said.
Jul 29, 2021
Researchers film human viruses in liquid droplets at near-atomic detail
A research team led by Deb Kelly, Huck Chair in Molecular Biophysics and professor of biomedical engineering at Penn State, has used advanced electron microscopy (EM) technology to see how human viruses move in high resolution in a near-native environment. The visualization technique could lead to improved understanding of how vaccine candidates and treatments behave and function as they interact with target cells, Kelly said.
Apr 08, 2021
Antibody binding-site conserved across COVID-19 virus variants
A tiny protein of SARS-CoV-2, the coronavirus that gives rise to COVID-19, may have big implications for future treatments, according to a team of Penn State researchers.
Jan 06, 2021
Engineering professor named Microscopy Society of America president-elect
Deborah Kelly, Huck Chair in Molecular Biophysics and professor of biomedical engineering at Penn State, was elected president of the Microscopy Society of America (MSA). Her three-year commitment as first president-elect, then president, then past president, began in January.
Nov 16, 2020
Deb Kelly named chair of NIH study section
Deborah Kelly, Penn State Lloyd & Dottie Foehr Huck Chair in Molecular Biophysics, director of the Penn State Center for Structural Oncology (CSO) and professor of biomedical engineering, has accepted an appointment as chair of the National Institutes of Health’s (NIH) Macromolecular Structure and Function B (MSFB) Study Section, directed by the Center for Scientific Review.
Jul 24, 2020
Podcast features three women at the forefront of cryo-EM research
An all-female trio of Penn State research scientists explain how their work on cancer diagnostics and advanced materials science evolves along with improvements in cryo-electron microscopy.
Apr 23, 2020
Penn State cancer research center joins pandemic fight
The Penn State Center for Structural Oncology (CSO) is shifting some of its focus from fighting cancer to fighting COVID-19, with three projects. The CSO’s director, Deborah Kelly, believes that the same interdisciplinary research approach and collaborative spirit that drives the CSO’s cancer research can be applied to fighting pandemics.
Jan 20, 2020
Aspiring neurosurgeon mapping cancer-suppressing protein
Madison Evans is a Penn State biomedical engineering major who would like to become a neurosurgeon. Before she heads off to medical school, though, the Schreyer Honors Scholar is part of a research project that could change the way her future patients receive treatment.
Jan 17, 2020
Discovering the Secret Life of Cancer Cells (pg. 14)
Penn State's Center for Structural Oncology seeks to understand molecular culprits of breast cancer
Oct 22, 2019
Professor of Biomedical Engineering Deb Kelly hopes to 'outsmart breast cancer'
October is National Breast Cancer Awareness Month. One of the pioneering researchers in the fight against breast cancer is Deb Kelly, professor of biomedical engineering and director of the Center for Structural Oncology at Penn State.