Patrick Drew
Associate Director of the Neuroscience Institute; Huck Distinguished Associate Professor of Neural Engineering and Neurosurgery
-
W317 Millennium Science Complex
University Park, - pjd17@psu.edu
- 814-863-1473
Research Summary
Role of blood flow and cerebrospinal fluid movement in the development of neurodegenerative diseases, control of cerebral blood flow, neurovascular coupling.
Huck Affiliations
- Neuroscience
- Integrative and Biomedical Physiology
- Molecular, Cellular, and Integrative Biosciences
- Neuroscience Institute
- Center for Molecular Investigation of Neurological Disorders
Links
Publication Tags
Hemodynamics Locomotion Brain Cerebral Blood Volume Photons Dilatation Cerebrovascular Circulation Blood Imaging Techniques Blood Vessels Constriction Oxygen Respiration Infection Bone Oxygenation Cerebrospinal Fluid Sudden Death Epilepsy Calcitonin Gene Related Peptide Radon Malaria Somatosensory Cortex Lasers VibrissaeMost Recent Papers
Cerebral oxygenation during locomotion is modulated by respiration
Qingguang Zhang, Morgane Roche, Kyle W. Gheres, Emmanuelle Chaigneau, Ravi T. Kedarasetti, William D. Haselden, Serge Charpak, Patrick J. Drew, 2019, Nature communications
Twitches, Blinks, and Fidgets
Patrick James Drew, Aaron T. Winder, Qingguang Zhang, 2019, Neuroscientist on p. 298-313
Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate
Jordan N. Norwood, Qingguang Zhang, David Card, Amanda Craine, Timothy M. Ryan, Patrick J. Drew, 2019, eLife
Weak correlations between hemodynamic signals and ongoing neural activity during the resting state
Aaron T. Winder, Christina Echagarruga, Qingguang Zhang, Patrick J. Drew, 2017, Nature Neuroscience on p. 1761-1769
A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection
Paddy Ssentongo, Anna E. Robuccio, Godfrey Thuku, Derek G. Sim, Ali Nabi, Fatemeh Bahari, Balaji Shanmugasundaram, Myles W. Billard, Andrew Geronimo, Kurt W. Short, Patrick J. Drew, Jennifer Baccon, Steven L. Weinstein, Frank G. Gilliam, José A. Stoute, Vernon M. Chinchilli, Andrew F. Read, Bruce J. Gluckman, Steven J. Schiff, 2017, Scientific reports
Effects of voluntary locomotion and calcitonin gene-related peptide on the dynamics of single dural vessels in awake mice
Yu Rong Gao, Patrick J. Drew, 2016, Journal of Neuroscience on p. 2503-2516
Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response
Yu Rong Gao, Stephanie E. Greene, Patrick J. Drew, 2015, NeuroImage on p. 162-176
Quantitative separation of arterial and venous cerebral blood volume increases during voluntary locomotion
Bing Xing Huo, Yu Rong Gao, Patrick J. Drew, 2015, NeuroImage on p. 369-379
Venous cerebral blood volume increase during voluntary locomotion reflects cardiovascular changes
Bing Xing Huo, Stephanie E. Greene, Patrick J. Drew, 2015, NeuroImage on p. 301-312
Determination of vessel cross-sectional area by thresholding in Radon space
Yu Rong Gao, Patrick J. Drew, 2014, Journal of Cerebral Blood Flow and Metabolism on p. 1180-1187
Most-Cited Papers
Fluctuating and sensory-induced vasodynamics in rodent cortex extend arteriole capacity
Patrick J. Drew, Andy Y. Shih, David Kleinfeld, 2011, Proceedings of the National Academy of Sciences of the United States of America on p. 8473-8478
A polished and reinforced thinned-skull window for long-term imaging of the mouse brain.
Andy Y. Shih, Celine Mateo, Patrick James Drew, Philbert S. Tsai, David Kleinfeld, 2012, Journal of visualized experiments : JoVE
Weak correlations between hemodynamic signals and ongoing neural activity during the resting state
Aaron T. Winder, Christina Echagarruga, Qingguang Zhang, Patrick J. Drew, 2017, Nature Neuroscience on p. 1761-1769
Quantitative separation of arterial and venous cerebral blood volume increases during voluntary locomotion
Bing Xing Huo, Yu Rong Gao, Patrick J. Drew, 2015, NeuroImage on p. 369-379
Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response
Yu Rong Gao, Stephanie E. Greene, Patrick J. Drew, 2015, NeuroImage on p. 162-176
Determination of vessel cross-sectional area by thresholding in Radon space
Yu Rong Gao, Patrick J. Drew, 2014, Journal of Cerebral Blood Flow and Metabolism on p. 1180-1187
Effects of voluntary locomotion and calcitonin gene-related peptide on the dynamics of single dural vessels in awake mice
Yu Rong Gao, Patrick J. Drew, 2016, Journal of Neuroscience on p. 2503-2516
Venous cerebral blood volume increase during voluntary locomotion reflects cardiovascular changes
Bing Xing Huo, Stephanie E. Greene, Patrick J. Drew, 2015, NeuroImage on p. 301-312
Two-photon imaging of blood flow in the rat cortex
Jonathan D. Driscoll, Andy Y. Shih, Patrick J. Drew, Gert Cauwenberghs, David Kleinfeld, 2013, Cold Spring Harbor Protocols on p. 759-767
A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection
Paddy Ssentongo, Anna E. Robuccio, Godfrey Thuku, Derek G. Sim, Ali Nabi, Fatemeh Bahari, Balaji Shanmugasundaram, Myles W. Billard, Andrew Geronimo, Kurt W. Short, Patrick J. Drew, Jennifer Baccon, Steven L. Weinstein, Frank G. Gilliam, José A. Stoute, Vernon M. Chinchilli, Andrew F. Read, Bruce J. Gluckman, Steven J. Schiff, 2017, Scientific reports
News Articles Featuring Patrick Drew
Dec 05, 2019
Want to Increase Brain Oxygenation? Locomotion May Be Key
Sometimes, it takes neuroscientists much longer than one might expect to substantiate everyday observations that seem like common sense.
Full Article
Dec 04, 2019
Respiration key to increase oxygen in the brain
Contrary to accepted knowledge, blood can bring more oxygen to mice brains when they exercise because the increased respiration packs more oxygen into the hemoglobin, according to an international team of researchers who believe that this holds true for all mammals.
Full Article
Sep 24, 2019
Patrick Drew named associate director of Penn State’s Neuroscience Institute
Drew succeeds David Vandenbergh in an important role promoting Neuroscience research and education at University Park.
Full Article
Jul 01, 2019
Sense of smell, pollution and neurological disease connection explored
A consensus is building that air pollution can cause neurological diseases such as Alzheimer's disease and Parkinson's disease, but how fine, sooty particles cause problems in the brain is still an unanswered question. Now a team of Penn State researchers, using mice, have found a possible way, but more research is still needed.
Full Article
May 07, 2019
Institutes of Energy and the Environment announces seed grant recipients
Several Huck researchers are among the recipients of 2018-19 IEE seed grants.
Full Article