Patrick Drew
Associate Director of the Neuroscience Institute; Huck Distinguished Associate Professor of Neural Engineering and Neurosurgery
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W317 Millennium Science Complex
University Park, - pjd17@psu.edu
- 814-863-1473
Research Summary
Role of blood flow and cerebrospinal fluid movement in the development of neurodegenerative diseases, control of cerebral blood flow, neurovascular coupling.
Huck Affiliations
- Neuroscience
- Integrative and Biomedical Physiology
- Molecular, Cellular, and Integrative Biosciences
- Neuroscience Institute
- Center for Molecular Investigation of Neurological Disorders
Links
Publication Tags
Brain Locomotion Hemodynamics Blood Photons Cerebral Blood Volume Photosensitizing Agents Imaging Techniques Dilatation Respiration Radon Oxygenation Bone Skull Oxygen Microglia Lasers Lighting Blood Vessels Frontal Lobe Glass Neurovascular Coupling Head Neuroimaging ArteriolesMost Recent Papers
Rude Mechanicals in Brain Hemodynamics: Non-Neural Actors that Influence Blood Flow
Anirhudda Das, Kevin Murphy, Patrick Drew, 2020, Philosophical Transactions of the Royal Society B
Functional hyperemia drives fluid exchange in the paravascular space.
R Kedarasetti, K Turner, C Echagarruga, Bruce Gluckman, Patrick Drew, Francesco Costanzo, 2020, Fluids and barriers of the CNS on p. 52
Ultra-slow Oscillations in fMRI and Resting-State Connectivity: Neuronal and Vascular Contributions and Technical Confounds.
Patrick Drew, C Mateo, K Turner, X Yu, D Kleinfeld, 2020, Neuron
Spatial and temporal patterns of nitric oxide diffusion and degradation drive emergent cerebrovascular dynamics.
W Haselden, R Kedarasetti, Patrick Drew, 2020, PLoS computational biology on p. e1008069
Arterial pulsations drive oscillatory flow of CSF but not directional pumping.
R Kedarasetti, Patrick Drew, Francesco Costanzo, 2020, Scientific reports on p. 10102
Transfer functions linking neural calcium to single voxel functional ultrasound signal.
A Aydin, W Haselden, Y Goulam Houssen, C Pouzat, R Rungta, C Demené, M Tanter, Patrick Drew, S Charpak, D Boido, 2020, Nature communications on p. 2954
Cerebral oxygenation during locomotion is modulated by respiration
Qingguang Zhang, Morgane Roche, Kyle W. Gheres, Emmanuelle Chaigneau, Ravi T. Kedarasetti, William D. Haselden, Serge Charpak, Patrick J. Drew, 2019, Nature communications on p. 5515
Twitches, Blinks, and Fidgets
Patrick James Drew, Aaron T. Winder, Qingguang Zhang, 2019, Neuroscientist on p. 298-313
Vascular and neural basis of the BOLD signal.
Patrick Drew, 2019, Current opinion in neurobiology on p. 61-69
Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate.
J Norwood, Q Zhang, D Card, A Craine, Timothy Ryan, Patrick Drew, 2019, eLife
Most-Cited Papers
Chronic optical access through a polished and reinforced thinned skull
Patrick J. Drew, Andy Y. Shih, Jonathan D. Driscoll, Per Magne Knutsen, Pablo Blinder, Dimitrios Davalos, Katerina Akassoglou, Philbert S. Tsai, David Kleinfeld, 2010, Nature Methods on p. 981-984
Fluctuating and sensory-induced vasodynamics in rodent cortex extend arteriole capacity
Patrick J. Drew, Andy Y. Shih, David Kleinfeld, 2011, Proceedings of the National Academy of Sciences of the United States of America on p. 8473-8478
Rapid determination of particle velocity from space-time images using the Radon transform
Patrick J. Drew, Pablo Blinder, Gert Cauwenberghs, Andy Y. Shih, David Kleinfeld, 2010, Journal of Computational Neuroscience on p. 5-11
A polished and reinforced thinned-skull window for long-term imaging of the mouse brain.
Andy Y. Shih, Celine Mateo, Patrick James Drew, Philbert S. Tsai, David Kleinfeld, 2012, Journal of visualized experiments : JoVE
Neurovascular coupling and decoupling in the cortex during voluntary locomotion
Bing Xing Huo, Jared B. Smith, Patrick James Drew, 2014, Journal of Neuroscience on p. 10975-10981
Weak correlations between hemodynamic signals and ongoing neural activity during the resting state
Aaron T. Winder, Christina Echagarruga, Qingguang Zhang, Patrick J. Drew, 2017, Nature Neuroscience on p. 1761-1769
Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response
Yu Rong Gao, Stephanie E. Greene, Patrick J. Drew, 2015, NeuroImage on p. 162-176
Quantitative separation of arterial and venous cerebral blood volume increases during voluntary locomotion
Bing Xing Huo, Yu Rong Gao, Patrick J. Drew, 2015, NeuroImage on p. 369-379
Brief anesthesia, but not voluntary locomotion, significantly alters cortical temperature
Michael J. Shirey, Jared B. Smith, D’Anne E. Kudlik, Bing Xing Huo, Stephanie E. Greene, Patrick J. Drew, 2015, Journal of neurophysiology on p. 309-322
Determination of vessel cross-sectional area by thresholding in Radon space
Yu Rong Gao, Patrick J. Drew, 2014, Journal of Cerebral Blood Flow and Metabolism on p. 1180-1187
News Articles Featuring Patrick Drew
Dec 05, 2019
Want to Increase Brain Oxygenation? Locomotion May Be Key
Sometimes, it takes neuroscientists much longer than one might expect to substantiate everyday observations that seem like common sense.
Full Article
Dec 04, 2019
Respiration key to increase oxygen in the brain
Contrary to accepted knowledge, blood can bring more oxygen to mice brains when they exercise because the increased respiration packs more oxygen into the hemoglobin, according to an international team of researchers who believe that this holds true for all mammals.
Full Article
Sep 24, 2019
Patrick Drew named associate director of Penn State’s Neuroscience Institute
Drew succeeds David Vandenbergh in an important role promoting Neuroscience research and education at University Park.
Full Article
Jul 01, 2019
Sense of smell, pollution and neurological disease connection explored
A consensus is building that air pollution can cause neurological diseases such as Alzheimer's disease and Parkinson's disease, but how fine, sooty particles cause problems in the brain is still an unanswered question. Now a team of Penn State researchers, using mice, have found a possible way, but more research is still needed.
Full Article
May 07, 2019
Institutes of Energy and the Environment announces seed grant recipients
Several Huck researchers are among the recipients of 2018-19 IEE seed grants.
Full Article