Patrick Drew

Associate Director of the Neuroscience Institute; Huck Distinguished Associate Professor of Neural Engineering and Neurosurgery

Patrick Drew

Research Summary

Role of blood flow and cerebrospinal fluid movement in the development of neurodegenerative diseases, control of cerebral blood flow, neurovascular coupling.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Brain Hemodynamics Neurovascular Coupling Photons Oxygen Cerebrospinal Fluid Cerebral Blood Volume Locomotion Imaging Techniques Blood Flow Bone Dioxygen Mice Dilatation Animals Microscopy Arterioles Glass Erythrocytes Blood Vessels Neuroimaging Oxygenation Rodentia Head

Most Recent Publications

Ravi Teja Kedarasetti, Patrick J. Drew, Francesco Costanzo, 2022, Fluids and Barriers of the CNS

Yuan ting Wu, Hannah C. Bennett, Uree Chon, Daniel J. Vanselow, Qingguang Zhang, Rodrigo Muñoz-Castañeda, Keith C. Cheng, Pavel Osten, Patrick J. Drew, Yongsoo Kim, 2022, Cell Reports

Qingguang Zhang, Kevin L. Turner, Kyle W. Gheres, Md Shakhawat Hossain, Patrick J. Drew, 2022, Neurophotonics

Shubham Mirg, Haoyang Chen, Kevin L. Turner, Kyle W. Gheres, Jinyun Liu, Bruce J. Gluckman, Patrick J. Drew, Sri Rajasekhar Kothapalli, 2022, Optics Letters on p. 1121-1124

Could respiration-driven blood oxygen changes modulate neural activity?

Qingguang Zhang, William D. Haselden, Serge Charpak, Patrick J. Drew, 2022, Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere

Neurovascular coupling: motive unknown

Patrick J. Drew, 2022, Trends in Neurosciences

Photoacoustic imaging for microcirculation

Shubham Mirg, Kevin L. Turner, Haoyang Chen, Patrick J. Drew, Sri Rajasekhar Kothapalli, 2022, Microcirculation

Cerebral Oxygenation Dynamics in Awake Behaving Mice

Qingguang Zhang, Morgane Roche, Kyle W. Gheres, Emmanuelle Chaigneau, William D. Haselden, Ravi T. Kedarasetti, Serge Charpak, Patrick J. Drew, 2022,

Qingguang Zhang, Kyle W. Gheres, Patrick J. Drew, 2021, PLoS Biology

Most-Cited Papers

Andy Y. Shih, Jonathan D. Driscoll, Patrick J. Drew, Nozomi Nishimura, Chris B. Schaffer, David Kleinfeld, 2012, Journal of Cerebral Blood Flow and Metabolism on p. 1277-1309

Andy Y. Shih, Celine Mateo, Patrick James Drew, Philbert S. Tsai, David Kleinfeld, 2012, Journal of Visualized Experiments

Yu Rong Gao, Yuncong Ma, Qingguang Zhang, Aaron T. Winder, Zhifeng Liang, Lilith Antinori, Patrick J. Drew, Nanyin Zhang, 2017, NeuroImage on p. 382-398

Aaron T. Winder, Christina Echagarruga, Qingguang Zhang, Patrick J. Drew, 2017, Nature Neuroscience on p. 1761-1769

Andy Y. Shih, Charlotta Rühlmann, Pablo Blinder, Anna Devor, Patrick J. Drew, Beth Friedman, Per M. Knutsen, Patrick D. Lyden, Céline Matéo, Lisa Mellander, Nozomi Nishimura, Chris B. Schaffer, Philbert S. Tsai, David Kleinfeld, 2015, Microcirculation on p. 204-218

Bing Xing Huo, Jared B. Smith, Patrick J. Drew, 2014, Journal of Neuroscience on p. 10975-10981

Jordan N. Norwood, Qingguang Zhang, David Card, Amanda Craine, Timothy M. Ryan, Patrick J. Drew, 2019, eLife

Yu Rong Gao, Stephanie E. Greene, Patrick J. Drew, 2015, NeuroImage on p. 162-176

Bing Xing Huo, Yu Rong Gao, Patrick J. Drew, 2015, NeuroImage on p. 369-379

Ravi Kedarasetti, Patrick J. Drew, Francesco Costanzo, 2020, Scientific Reports on p. 10:10102-1–10:10102-12

News Articles Featuring Patrick Drew

Researchers publish how-to guide for monitoring and analyzing brain activity

Penn State researchers have developed a set of tools and methods to better monitor and analyze sleep-related signals and fidgeting in rodent brain studies. Considered the bedrock of biomedical research, rodent studies often provide the first advanced understanding of brain activity and are the foundation on which human studies are eventually built.

Increased blood flow during sleep tied to critical brain function

Our brains experience significant changes in blood flow and neural activity during sleep, according to Penn State researchers. Such changes may help to clean out metabolic brain waste that builds up during the day.

Some neurons target tiny cerebral blood vessel dilation

Neurons control blood flow in tiny vessels in the brain, but researchers know little about this relationship. Now a team of Penn State engineers has found a connection between nitric oxide expressing neurons and changes in arterial diameters in mice, which may shed light on brain function and aging.

Want to Increase Brain Oxygenation? Locomotion May Be Key

Sometimes, it takes neuroscientists much longer than one might expect to substantiate everyday observations that seem like common sense.

Respiration key to increase oxygen in the brain

Contrary to accepted knowledge, blood can bring more oxygen to mice brains when they exercise because the increased respiration packs more oxygen into the hemoglobin, according to an international team of researchers who believe that this holds true for all mammals.

Patrick Drew named associate director of Penn State’s Neuroscience Institute

Drew succeeds David Vandenbergh in an important role promoting Neuroscience research and education at University Park.

Sense of smell, pollution and neurological disease connection explored

A consensus is building that air pollution can cause neurological diseases such as Alzheimer's disease and Parkinson's disease, but how fine, sooty particles cause problems in the brain is still an unanswered question. Now a team of Penn State researchers, using mice, have found a possible way, but more research is still needed.

Institutes of Energy and the Environment announces seed grant recipients

Several Huck researchers are among the recipients of 2018-19 IEE seed grants.