Associate Director of the Neuroscience Institute; Huck Distinguished Associate Professor of Neural Engineering and Neurosurgery
Role of blood flow and cerebrospinal fluid movement in the development of neurodegenerative diseases, control of cerebral blood flow, neurovascular coupling.
Huck Graduate Students
- Integrative and Biomedical Physiology
- Molecular, Cellular, and Integrative Biosciences
- Neuroscience Institute
- Center for Molecular Investigation of Neurological Disorders
- Center for Brain, Behavior, and Cognition
Publication TagsBrain Hemodynamics Neurovascular Coupling Photons Oxygen Cerebrospinal Fluid Cerebral Blood Volume Locomotion Imaging Techniques Blood Flow Bone Dioxygen Mice Dilatation Animals Microscopy Arterioles Glass Erythrocytes Blood Vessels Neuroimaging Oxygenation Rodentia Head
Most Recent Publications
Ravi Teja Kedarasetti, Patrick J. Drew, Francesco Costanzo, 2022, Fluids and Barriers of the CNS
Author Correction: Weak correlations between hemodynamic signals and ongoing neural activity during the resting state (Nature Neuroscience, (2017), 20, 12, (1761-1769), 10.1038/s41593-017-0007-y)
Aaron T. Winder, Christina Echagarruga, Qingguang Zhang, Patrick J. Drew, 2022, Nature Neuroscience on p. 975
Yuan ting Wu, Hannah C. Bennett, Uree Chon, Daniel J. Vanselow, Qingguang Zhang, Rodrigo Muñoz-Castañeda, Keith C. Cheng, Pavel Osten, Patrick J. Drew, Yongsoo Kim, 2022, Cell Reports
Behavioral and physiological monitoring for awake neurovascular coupling experiments: a how-to guide
Qingguang Zhang, Kevin L. Turner, Kyle W. Gheres, Md Shakhawat Hossain, Patrick J. Drew, 2022, Neurophotonics
Shubham Mirg, Haoyang Chen, Kevin L. Turner, Kyle W. Gheres, Jinyun Liu, Bruce J. Gluckman, Patrick J. Drew, Sri Rajasekhar Kothapalli, 2022, Optics Letters on p. 1121-1124
Could respiration-driven blood oxygen changes modulate neural activity?
Qingguang Zhang, William D. Haselden, Serge Charpak, Patrick J. Drew, 2022, Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere
Neurovascular coupling: motive unknown
Patrick J. Drew, 2022, Trends in Neurosciences
Photoacoustic imaging for microcirculation
Shubham Mirg, Kevin L. Turner, Haoyang Chen, Patrick J. Drew, Sri Rajasekhar Kothapalli, 2022, Microcirculation
Cerebral Oxygenation Dynamics in Awake Behaving Mice
Qingguang Zhang, Morgane Roche, Kyle W. Gheres, Emmanuelle Chaigneau, William D. Haselden, Ravi T. Kedarasetti, Serge Charpak, Patrick J. Drew, 2022,
Qingguang Zhang, Kyle W. Gheres, Patrick J. Drew, 2021, PLoS Biology
Andy Y. Shih, Jonathan D. Driscoll, Patrick J. Drew, Nozomi Nishimura, Chris B. Schaffer, David Kleinfeld, 2012, Journal of Cerebral Blood Flow and Metabolism on p. 1277-1309
Andy Y. Shih, Celine Mateo, Patrick James Drew, Philbert S. Tsai, David Kleinfeld, 2012, Journal of Visualized Experiments
Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal
Yu Rong Gao, Yuncong Ma, Qingguang Zhang, Aaron T. Winder, Zhifeng Liang, Lilith Antinori, Patrick J. Drew, Nanyin Zhang, 2017, NeuroImage on p. 382-398
Aaron T. Winder, Christina Echagarruga, Qingguang Zhang, Patrick J. Drew, 2017, Nature Neuroscience on p. 1761-1769
Andy Y. Shih, Charlotta Rühlmann, Pablo Blinder, Anna Devor, Patrick J. Drew, Beth Friedman, Per M. Knutsen, Patrick D. Lyden, Céline Matéo, Lisa Mellander, Nozomi Nishimura, Chris B. Schaffer, Philbert S. Tsai, David Kleinfeld, 2015, Microcirculation on p. 204-218
Bing Xing Huo, Jared B. Smith, Patrick J. Drew, 2014, Journal of Neuroscience on p. 10975-10981
Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate
Jordan N. Norwood, Qingguang Zhang, David Card, Amanda Craine, Timothy M. Ryan, Patrick J. Drew, 2019, eLife
Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response
Yu Rong Gao, Stephanie E. Greene, Patrick J. Drew, 2015, NeuroImage on p. 162-176
Quantitative separation of arterial and venous cerebral blood volume increases during voluntary locomotion
Bing Xing Huo, Yu Rong Gao, Patrick J. Drew, 2015, NeuroImage on p. 369-379
Ravi Kedarasetti, Patrick J. Drew, Francesco Costanzo, 2020, Scientific Reports on p. 10:10102-1–10:10102-12
News Articles Featuring Patrick Drew
Mar 03, 2022
Researchers publish how-to guide for monitoring and analyzing brain activity
Penn State researchers have developed a set of tools and methods to better monitor and analyze sleep-related signals and fidgeting in rodent brain studies. Considered the bedrock of biomedical research, rodent studies often provide the first advanced understanding of brain activity and are the foundation on which human studies are eventually built.
Jan 18, 2021
Increased blood flow during sleep tied to critical brain function
Our brains experience significant changes in blood flow and neural activity during sleep, according to Penn State researchers. Such changes may help to clean out metabolic brain waste that builds up during the day.
Dec 16, 2020
Some neurons target tiny cerebral blood vessel dilation
Neurons control blood flow in tiny vessels in the brain, but researchers know little about this relationship. Now a team of Penn State engineers has found a connection between nitric oxide expressing neurons and changes in arterial diameters in mice, which may shed light on brain function and aging.
Dec 05, 2019
Want to Increase Brain Oxygenation? Locomotion May Be Key
Sometimes, it takes neuroscientists much longer than one might expect to substantiate everyday observations that seem like common sense.
Dec 04, 2019
Respiration key to increase oxygen in the brain
Contrary to accepted knowledge, blood can bring more oxygen to mice brains when they exercise because the increased respiration packs more oxygen into the hemoglobin, according to an international team of researchers who believe that this holds true for all mammals.
Sep 24, 2019
Patrick Drew named associate director of Penn State’s Neuroscience Institute
Drew succeeds David Vandenbergh in an important role promoting Neuroscience research and education at University Park.
Jul 01, 2019
Sense of smell, pollution and neurological disease connection explored
A consensus is building that air pollution can cause neurological diseases such as Alzheimer's disease and Parkinson's disease, but how fine, sooty particles cause problems in the brain is still an unanswered question. Now a team of Penn State researchers, using mice, have found a possible way, but more research is still needed.
May 07, 2019
Institutes of Energy and the Environment announces seed grant recipients
Several Huck researchers are among the recipients of 2018-19 IEE seed grants.