Patrick Drew

Associate Director of the Neuroscience Institute; Huck Distinguished Associate Professor of Neural Engineering and Neurosurgery

Patrick Drew

Research Summary

Role of blood flow and cerebrospinal fluid movement in the development of neurodegenerative diseases, control of cerebral blood flow, neurovascular coupling.

Huck Graduate Students

Huck Affiliations


Publication Tags

Brain Hemodynamics Blood Vessels Blood Neurovascular Coupling Nitric Oxide Magnetic Resonance Imaging Neurons Locomotion Photons Arterioles Degradation Calcium Imaging Techniques Cerebral Blood Volume Dilatation Oxygenation Respiration Animals Microscopy Somatosensory Cortex Transfer Functions Sleep Bone Rodentia

Most Recent Papers

Rude mechanicals in brain haemodynamics: non-neural actors that influence blood flow

Aniruddha Das, Kevin Murphy, Patrick J. Drew, 2021, Philosophical Transactions of the Royal Society B: Biological Sciences on p. 20190635

Transfer functions linking neural calcium to single voxel functional ultrasound signal

Ali Kemal Aydin, William D. Haselden, Yannick Goulam Houssen, Christophe Pouzat, Ravi L. Rungta, Charlie Demené, Mickael Tanter, Patrick J. Drew, Serge Charpak, Davide Boido, 2020, Nature Communications

Arterial pulsations drive oscillatory flow of CSF but not directional pumping

Ravi Teja Kedarasetti, Patrick J. Drew, Francesco Costanzo, 2020, Scientific Reports

nNos-expressing interneurons control basal and behaviorally evoked arterial dilation in somatosensory cortex of mice

Christina T. Echagarruga, Kyle W. Gheres, Jordan N. Norwood, Patrick J. Drew, 2020, eLife on p. 1-39

Neurovascular coupling and bilateral connectivity during nrem and rem sleep

Kevin L. Turner, Kyle W. Gheres, Elizabeth A. Proctor, Patrick J. Drew, 2020, eLife on p. 1

Ultra-slow Oscillations in fMRI and Resting-State Connectivity

Patrick J. Drew, Celine Mateo, Kevin L. Turner, Xin Yu, David Kleinfeld, 2020, Neuron on p. 782-804

Functional hyperemia drives fluid exchange in the paravascular space

Ravi Teja Kedarasetti, Kevin L. Turner, Christina Echagarruga, Bruce J. Gluckman, Patrick J. Drew, Francesco Costanzo, 2020, Fluids and Barriers of the CNS

Spatial and temporal patterns of nitric oxide diffusion and degradation drive emergent cerebrovascular dynamics

William Davis Haselden, Ravi Teja Kedarasetti, Patrick J. Drew, 2020, PLoS Computational Biology

Cerebral oxygenation during locomotion is modulated by respiration

Qingguang Zhang, Morgane Roche, Kyle W. Gheres, Emmanuelle Chaigneau, Ravi T. Kedarasetti, William D. Haselden, Serge Charpak, Patrick J. Drew, 2019, Nature Communications on p. 5515

Vascular and neural basis of the BOLD signal

Patrick J. Drew, 2019, Current Opinion in Neurobiology on p. 61-69

Most-Cited Papers

Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain

Andy Y. Shih, Jonathan D. Driscoll, Patrick J. Drew, Nozomi Nishimura, Chris B. Schaffer, David Kleinfeld, 2012, Journal of Cerebral Blood Flow and Metabolism on p. 1277-1309

Fluctuating and sensory-induced vasodynamics in rodent cortex extend arteriole capacity

Patrick J. Drew, Andy Y. Shih, David Kleinfeld, 2011, Proceedings of the National Academy of Sciences of the United States of America on p. 8473-8478

A polished and reinforced thinned-skull window for long-term imaging of the mouse brain.

Andy Y. Shih, Celine Mateo, Patrick James Drew, Philbert S. Tsai, David Kleinfeld, 2012, Journal of Visualized Experiments

Time to wake up

Yu Rong Gao, Yuncong Ma, Qingguang Zhang, Aaron T. Winder, Zhifeng Liang, Lilith Antinori, Patrick J. Drew, Nanyin Zhang, 2017, NeuroImage on p. 382-398

A guide to delineate the logic of neurovascular signaling in the brain

David Kleinfeld, Pablo Blinder, Patrick J. Drew, Jonathan D. Driscoll, Arnaud Muller, Philbert S. Tsai, Andy Y. Shih, 2011, Frontiers in Neuroenergetics on p. 1-9

Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture

Andy Y. Shih, Charlotta Rühlmann, Pablo Blinder, Anna Devor, Patrick J. Drew, Beth Friedman, Per M. Knutsen, Patrick D. Lyden, Céline Matéo, Lisa Mellander, Nozomi Nishimura, Chris B. Schaffer, Philbert S. Tsai, David Kleinfeld, 2015, Microcirculation on p. 204-218

Neurovascular coupling and decoupling in the cortex during voluntary locomotion

Bing Xing Huo, Jared B. Smith, Patrick James Drew, 2014, Journal of Neuroscience on p. 10975-10981

Weak correlations between hemodynamic signals and ongoing neural activity during the resting state

Aaron T. Winder, Christina Echagarruga, Qingguang Zhang, Patrick J. Drew, 2017, Nature Neuroscience on p. 1761-1769

Quantitative separation of arterial and venous cerebral blood volume increases during voluntary locomotion

Bing Xing Huo, Yu Rong Gao, Patrick J. Drew, 2015, NeuroImage on p. 369-379

Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response

Yu Rong Gao, Stephanie E. Greene, Patrick J. Drew, 2015, NeuroImage on p. 162-176

News Articles Featuring Patrick Drew

Increased blood flow during sleep tied to critical brain function

Our brains experience significant changes in blood flow and neural activity during sleep, according to Penn State researchers. Such changes may help to clean out metabolic brain waste that builds up during the day.

Some neurons target tiny cerebral blood vessel dilation

Neurons control blood flow in tiny vessels in the brain, but researchers know little about this relationship. Now a team of Penn State engineers has found a connection between nitric oxide expressing neurons and changes in arterial diameters in mice, which may shed light on brain function and aging.

Want to Increase Brain Oxygenation? Locomotion May Be Key

Sometimes, it takes neuroscientists much longer than one might expect to substantiate everyday observations that seem like common sense.

Respiration key to increase oxygen in the brain

Contrary to accepted knowledge, blood can bring more oxygen to mice brains when they exercise because the increased respiration packs more oxygen into the hemoglobin, according to an international team of researchers who believe that this holds true for all mammals.

Patrick Drew named associate director of Penn State’s Neuroscience Institute

Drew succeeds David Vandenbergh in an important role promoting Neuroscience research and education at University Park.

Sense of smell, pollution and neurological disease connection explored

A consensus is building that air pollution can cause neurological diseases such as Alzheimer's disease and Parkinson's disease, but how fine, sooty particles cause problems in the brain is still an unanswered question. Now a team of Penn State researchers, using mice, have found a possible way, but more research is still needed.

Institutes of Energy and the Environment announces seed grant recipients

Several Huck researchers are among the recipients of 2018-19 IEE seed grants.