Patrick Drew

Associate Director of the Institute of the Neurosciences; Huck Distinguished Associate Professor of Neural Engineering and Neurosurgery

Patrick Drew

Research Summary

Role of blood flow and cerebrospinal fluid movement in the development of neurodegenerative diseases, control of cerebral blood flow, neurovascular coupling.

Huck Affiliations

Links

Publication Tags

Brain Hemodynamics Locomotion Dilatation Cerebral Blood Volume Somatosensory Cortex Vibrissae Arterioles Blood Photons Blood Vessels Photosensitizing Agents Radon Imaging Techniques Skull Bone Microglia Lasers Lighting Neocortex Neurovascular Coupling Constriction Glass Erythrocytes Cerebrovascular Circulation

Most Recent Papers

The pial vasculature of the mouse develops according to a sensory-independent program

Matthew Daniel Adams, Aaron T. Winder, Pablo Blinder, Patrick James Drew, 2018, Scientific reports

Twitches, Blinks, and Fidgets

Patrick James Drew, Aaron T. Winder, Qingguang Zhang, 2018, Neuroscientist

Weak correlations between hemodynamic signals and ongoing neural activity during the resting state

Aaron T. Winder, Christina Echagarruga, Qingguang Zhang, Patrick James Drew, 2017, Nature Neuroscience on p. 1761-1769

A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection

Paddy Ssentongo, Anna E. Robuccio, Godfrey Thuku, Derek Gordon Sim, Ali Nabi, Fatemeh Bahari, Balaji Shanmugasundaram, Myles W. Billard, Andrew Geronimo, Kurt W. Short, Patrick James Drew, Jennifer Baccon, Steven L. Weinstein, Frank G. Gilliam, Jose Stoute, Vernon Chinchilli, Andrew Fraser Read, Bruce Gluckman, Steven Schiff, 2017, Scientific reports

Effects of voluntary locomotion and calcitonin gene-related peptide on the dynamics of single dural vessels in awake mice

Yu Rong Gao, Patrick James Drew, 2016, Journal of Neuroscience on p. 2503-2516

Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response

Yu Rong Gao, Stephanie E. Greene, Patrick James Drew, 2015, NeuroImage on p. 162-176

Brief anesthesia, but not voluntary locomotion, significantly alters cortical temperature

Michael J. Shirey, Jared B. Smith, D’Anne E. Kudlik, Bing Xing Huo, Stephanie E. Greene, Patrick James Drew, 2015, Journal of Neurophysiology on p. 309-322

Quantitative separation of arterial and venous cerebral blood volume increases during voluntary locomotion

Bing Xing Huo, Yu Rong Gao, Patrick James Drew, 2015, NeuroImage on p. 369-379

Venous cerebral blood volume increase during voluntary locomotion reflects cardiovascular changes

Bing Xing Huo, Stephanie E. Greene, Patrick James Drew, 2015, NeuroImage on p. 301-312

Determination of vessel cross-sectional area by thresholding in Radon space

Yu Rong Gao, Patrick James Drew, 2014, Journal of Cerebral Blood Flow and Metabolism on p. 1180-1187

High-Impact Papers

Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels

Philbert S. Tsai, John P. Kaufhold, Pablo Blinder, Beth Friedman, Patrick J. Drew, Harvey J. Karten, Patrick D. Lyden, David Kleinfeld, 2009, Journal of Neuroscience on p. 14553-14570

Chronic optical access through a polished and reinforced thinned skull

Patrick J. Drew, Andy Y. Shih, Jonathan D. Driscoll, Per Magne Knutsen, Pablo Blinder, Dimitrios Davalos, Katerina Akassoglou, Philbert S. Tsai, David Kleinfeld, 2010, Nature Methods on p. 981-984

Fluctuating and sensory-induced vasodynamics in rodent cortex extend arteriole capacity

Patrick James Drew, Andy Y. Shih, David Kleinfeld, 2011, Proceedings of the National Academy of Sciences of the United States of America on p. 8473-8478

Active dilation of penetrating arterioles restores red blood cell flux to penumbral neocortex after focal stroke

Andy Y. Shih, Beth Friedman, Patrick James Drew, Philbert S. Tsai, Patrick D. Lyden, David Kleinfeld, 2009, Journal of Cerebral Blood Flow and Metabolism on p. 738-751

Rapid determination of particle velocity from space-time images using the Radon transform

Patrick J. Drew, Pablo Blinder, Gert Cauwenberghs, Andy Y. Shih, David Kleinfeld, 2010, Journal of Computational Neuroscience on p. 5-11

Endocannabinoid Signaling Is Required for Development and Critical Period Plasticity of the Whisker Map in Somatosensory Cortex

Lu Li, Kevin J. Bender, Patrick James Drew, Shantanu P. Jadhav, Emily Sylwestrak, Daniel E. Feldman, 2009, Neuron on p. 537-549

A polished and reinforced thinned-skull window for long-term imaging of the mouse brain.

Andy Y. Shih, Celine Mateo, Patrick James Drew, Philbert S. Tsai, David Kleinfeld, 2012, Journal of visualized experiments : JoVE

Intrinsic signal imaging of deprivation-induced contraction of whisker representations in rat somatosensory cortex

Patrick James Drew, Daniel E. Feldman, 2009, Cerebral Cortex on p. 331-348

Neurovascular coupling and decoupling in the cortex during voluntary locomotion

Bing Xing Huo, Jared B. Smith, Patrick James Drew, 2014, Journal of Neuroscience on p. 10975-10981

Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response

Yu Rong Gao, Stephanie E. Greene, Patrick James Drew, 2015, NeuroImage on p. 162-176