Patrick Drew

Associate Director, Huck Institutes of the Life Sciences; Professor of Engineering Science and Mechanics, of Neurosurgery, of Biology, and of Biomedical Engineering

Patrick Drew

Research Summary

Optical imaging of brain dynamics during sleep and behavior; Role of blood flow and cerebrospinal fluid movement in neurodegenerative disease

Huck Graduate Students

Huck Affiliations

Links

Most Recent Publications

Aging drives cerebrovascular network remodeling and functional changes in the mouse brain

H Bennett, Q Zhang, Y Wu, S Manjila, U Chon, D Shin, D Vanselow, H Pi, Patrick Drew, Yongsoo Kim, 2024, Nature Communications on p. 6398

Multiparametric Brain Hemodynamics Imaging Using a Combined Ultrafast Ultrasound and Photoacoustic System

Haoyang Chen, Shubham Mirg, Prameth Gaddale, S Agrawal, Sumit Agrawal, M Li, Menghan Li, V Nguyen, Van Nguyen, T Xu, Q Li, Tianbao Xu, J Liu, Qiong Li, W Tu, Jinyun Liu, Wenyu Tu, X Liu, Xiao Liu, Patrick Drew, Nanyin Zhang, Patrick J. Drew, Bruce Gluckman, S Kothapalli, Bruce J. Gluckman, Sri Rajasekhar Kothapalli, 2024, Advanced Science on p. 2401467

Dissecting Multiparametric Cerebral Hemodynamics using Integrated Ultrafast Ultrasound and Multispectral Photoacoustic Imaging.

H Chen, S Mirg, P Gaddale, S Agrawal, M Li, V Nguyen, T Xu, Q Li, J Liu, W Tu, X Liu, Patrick Drew, N Zhang, B Gluckman, S Kothapalli, 2023, bioRxiv : the preprint server for biology

Somatostatin peptide signaling dampens cortical circuits and promotes exploratory behavior

D Brockway, K Griffith, C Aloimonos, T Clarity, J Moyer, G Smith, N Dao, M Hossain, Patrick Drew, J Gordon, D Kupferschmidt, Nicole A. Crowley, 2023, Cell Reports on p. 112976

Aging drives cerebrovascular network remodeling and functional changes in the mouse brain.

H Bennett, Q Zhang, Y Wu, U Chon, H Pi, Patrick Drew, Y Kim, 2023, bioRxiv : the preprint server for biology

High-frequency neuronal signal better explains multi-phase BOLD response

Q Zhang, S Cramer, K Turner, Thomas Neuberger, Patrick Drew, Nanyin Zhang, 2023, NeuroImage on p. 119887

Relating Pupil Diameter and Blinking to Cortical Activity and Hemodynamics across Arousal States

K Turner, K Gheres, Patrick Drew, 2023, Journal of Neuroscience on p. 949-964

Parvalbumin interneuron activity drives fast inhibition-induced vasoconstriction followed by slow substance P-mediated vasodilation

Thanh Tan Vo, Geun Ho Im, Kayoung Han, Minah Suh, Patrick J. Drew, Seong Gi Kim, 2023, Proceedings of the National Academy of Sciences of the United States of America

Arousal state transitions occlude sensory-evoked neurovascular coupling in neonatal mice

Kyle W. Gheres, Hayreddin S. Ünsal, Xu Han, Qingguang Zhang, Kevin L. Turner, Nanyin Zhang, Patrick J. Drew, 2023, Communications Biology on p. 738

Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model

R. Kedarasetti, Patrick J. Drew, Francesco Costanzo, 2022, Fluids and Barriers of the CNS on p. 34-1–34-24

Most-Cited Papers

Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal

Yu Rong Gao, Yuncong Ma, Qingguang Zhang, Aaron T. Winder, Zhifeng Liang, Lilith Antinori, Patrick J. Drew, Nanyin Zhang, 2017, NeuroImage on p. 382-398

Weak correlations between hemodynamic signals and ongoing neural activity during the resting state

Aaron T. Winder, Christina Echagarruga, Qingguang Zhang, Patrick J. Drew, 2017, Nature Neuroscience on p. 1761-1769

Ultra-slow Oscillations in fMRI and Resting-State Connectivity: Neuronal and Vascular Contributions and Technical Confounds

Patrick J. Drew, C Mateo, K Turner, X Yu, D Kleinfeld, 2020, Neuron on p. 782-804

Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate

Jordan N. Norwood, Qingguang Zhang, David Card, Amanda Craine, Timothy M. Ryan, Patrick J. Drew, 2019, eLife

Vascular and neural basis of the BOLD signal

Patrick J. Drew, 2019, Current Opinion in Neurobiology on p. 61-69

Arterial pulsations drive oscillatory flow of CSF but not directional pumping

Ravi Kedarasetti, Patrick J. Drew, Francesco Costanzo, 2020, Scientific Reports on p. 10:10102-1–10:10102-12

Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture

Andy Y. Shih, Charlotta Rühlmann, Pablo Blinder, Anna Devor, Patrick J. Drew, Beth Friedman, Per M. Knutsen, Patrick D. Lyden, Céline Matéo, Lisa Mellander, Nozomi Nishimura, Chris B. Schaffer, Philbert S. Tsai, David Kleinfeld, 2015, Microcirculation on p. 204-218

Neurovascular coupling and bilateral connectivity during nrem and rem sleep

Kevin L. Turner, Kyle W. Gheres, Elizabeth A. Proctor, Patrick J. Drew, 2020, eLife on p. 1

Neurovascular coupling: motive unknown

Patrick Drew, 2022, Trends in Neurosciences on p. 809-819

Transfer functions linking neural calcium to single voxel functional ultrasound signal

Ali Kemal Aydin, William D. Haselden, Yannick Goulam Houssen, Christophe Pouzat, Ravi L. Rungta, Charlie Demené, Mickael Tanter, Patrick J. Drew, Serge Charpak, Davide Boido, 2020, Nature Communications

News Articles Featuring Patrick Drew

Jul 16, 2025

When dreams turn dark: Neuroscientists to study nightmares and mental health

Dreams, and likely nightmares, are experienced universally across humans and animals, but neuroscientists still do not know why. Now, with a three-year, $1.2 million grant from the W.M. Keck Foundation, an interdisciplinary team of researchers at Penn State will study the underlying mechanisms of nightmares and their relationship with anxiety-related mental health disorders, such as post-traumatic stress disorder (PTSD).

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Apr 25, 2025

Penn State graduate students receive American Heart Association fellowships

Two Penn State graduate students enrolled in Intercollege Graduate Degree Programs administered by the Huck Institutes of the Life Sciences have each been awarded two-year American Heart Association (AHA) Postdoctoral Fellowships.

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Jan 17, 2025

Christina Grozinger to lead Huck Institutes of the Life Sciences as director

Christina Grozinger, Publius Vergilius Maro Professor of Entomology and director of the Center for Pollinator Research, has been named the new director of the Huck Institutes of the Life Sciences at Penn State.

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Jan 03, 2025

Fourth annual Big Ten Neuroscience Symposium to convene at Penn State

The Penn State Neuroscience Institute, through the Huck Institutes of the Life Sciences and the Penn State College of Medicine, will host the Big Ten Neuroscience Annual Meeting on July 21 and 22 at the Nittany Lion Inn in State College.

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Jan 01, 2025

Alcohol and Sleep: How Drinking Affects Your Brain's Ability to Rest

The brain is affected by the lack of deep and restorative sleep, leaving you feeling unrested.

Full Article

Dec 17, 2024

New program aims to transform research administration with $5.1M NSF grant

The National Science Foundation (NSF) has awarded $5.1 million to support the Skilled Training in Administration and Institutional Research (STAIR) program, a national initiative designed to revolutionize research administration across U.S. academic institutions.

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Jul 30, 2024

New high-resolution 3D maps show how the brain’s blood vessels changes with age

Healthy blood vessels matter for more than just heart health. Vascular well-being is critical for brain health and potentially in addressing age-related cognitive decline and neurodegenerative disorders, like Alzheimer’s disease, according to new study led by Penn State researchers.

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Jun 05, 2024

Patrick Drew named interim director of the Huck Institutes of the Life Sciences

Patrick Drew, professor of engineering sciences and mechanics, of neurosurgery, of biology and of biomedical engineering and associate director of the Huck Institutes of the Life Sciences, has been selected to serve as interim director of the Huck Institutes with the appointment of Troy Ott as dean of the College of Agricultural Sciences at Penn State. Drew’s position will be effective July 1.

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Apr 23, 2024

Engineering professor named AIMBE fellow

Patrick Drew was inducted into the 2024 class of fellows for the American Institute for Medical and Biological Engineering (AIMBE). Drew also has affiliations with the departments of biomedical engineering, neurosurgery, and biology.

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Mar 03, 2022

Researchers publish how-to guide for monitoring and analyzing brain activity

Penn State researchers have developed a set of tools and methods to better monitor and analyze sleep-related signals and fidgeting in rodent brain studies. Considered the bedrock of biomedical research, rodent studies often provide the first advanced understanding of brain activity and are the foundation on which human studies are eventually built.

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Jan 18, 2021

Increased blood flow during sleep tied to critical brain function

Our brains experience significant changes in blood flow and neural activity during sleep, according to Penn State researchers. Such changes may help to clean out metabolic brain waste that builds up during the day.

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Dec 16, 2020

Some neurons target tiny cerebral blood vessel dilation

Neurons control blood flow in tiny vessels in the brain, but researchers know little about this relationship. Now a team of Penn State engineers has found a connection between nitric oxide expressing neurons and changes in arterial diameters in mice, which may shed light on brain function and aging.

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Dec 05, 2019

Want to Increase Brain Oxygenation? Locomotion May Be Key

Sometimes, it takes neuroscientists much longer than one might expect to substantiate everyday observations that seem like common sense.

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Dec 04, 2019

Respiration key to increase oxygen in the brain

Contrary to accepted knowledge, blood can bring more oxygen to mice brains when they exercise because the increased respiration packs more oxygen into the hemoglobin, according to an international team of researchers who believe that this holds true for all mammals.

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Sep 24, 2019

Patrick Drew named associate director of Penn State’s Neuroscience Institute

Drew succeeds David Vandenbergh in an important role promoting Neuroscience research and education at University Park.

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Jul 01, 2019

Sense of smell, pollution and neurological disease connection explored

A consensus is building that air pollution can cause neurological diseases such as Alzheimer's disease and Parkinson's disease, but how fine, sooty particles cause problems in the brain is still an unanswered question. Now a team of Penn State researchers, using mice, have found a possible way, but more research is still needed.

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May 07, 2019

Institutes of Energy and the Environment announces seed grant recipients

Several Huck researchers are among the recipients of 2018-19 IEE seed grants.

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