Patrick Drew

Associate Director of the Neuroscience Institute; Professor of Engineering Science and Mechanics, of Neurosurgery, of Biology, and of Biomedical Engineering

Patrick Drew

Research Summary

Optical imaging of brain dynamics during sleep and behavior; Role of blood flow and cerebrospinal fluid movement in neurodegenerative disease

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Publication Tags

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Brain Hemodynamics Blood Vessels Cerebrospinal Fluid Oxygen Cerebral Blood Volume Arterioles Neurovascular Coupling Oxygenation Vasodilation Magnetic Resonance Imaging Locomotion Drive Dioxygen Dilatation Neurons Somatosensory Cortex Optical Imaging Parvalbumins Arousal Neuroimaging Head Neurosciences Plate Like Crystal Blinking

Most Recent Publications

High-frequency neuronal signal better explains multi-phase BOLD response

Qingqing Zhang, Samuel R. Cramer, Kevin L. Turner, Thomas Neuberger, Patrick J. Drew, Nanyin Zhang, 2023, NeuroImage

Relating Pupil Diameter and Blinking to Cortical Activity and Hemodynamics across Arousal States

Kevin L. Turner, Kyle W. Gheres, Patrick J. Drew, 2023, Journal of Neuroscience on p. 949-964

Parvalbumin interneuron activity drives fast inhibition-induced vasoconstriction followed by slow substance P-mediated vasodilation

Thanh Tan Vo, Geun Ho Im, Kayoung Han, Minah Suh, Patrick J. Drew, Seong Gi Kim, 2023, Proceedings of the National Academy of Sciences of the United States of America

Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model

R. Kedarasetti, Patrick J. Drew, Francesco Costanzo, 2022, Fluids and Barriers of the CNS on p. 34-1–34-24

Lessons for the pathogenesis of vasospasm from a patient with sickle cell disease, moyamoya disease, subarachnoid hemorrhage, and 1 month of persistent vasospasm: illustrative case.

W Haselden, Patrick Drew, Ephraim Church, 2022, Journal of neurosurgery. Case lessons on p. CASE2290

Author Correction: Weak correlations between hemodynamic signals and ongoing neural activity during the resting state (Nature Neuroscience, (2017), 20, 12, (1761-1769), 10.1038/s41593-017-0007-y)

Aaron T. Winder, Christina Echagarruga, Qingguang Zhang, Patrick J. Drew, 2022, Nature Neuroscience on p. 975

Quantitative relationship between cerebrovascular network and neuronal cell types in mice

Yuan ting Wu, Hannah C. Bennett, Uree Chon, Daniel J. Vanselow, Qingguang Zhang, Rodrigo Mun˜ oz-Castan˜ eda, Rodrigo Muñoz-Castañeda, Keith C. Cheng, Pavel Osten, Patrick J. Drew, Yongsoo Kim, 2022, Cell Reports

Awake mouse brain photoacoustic and optical imaging through a transparent ultrasound cranial window

Shubham Mirg, Haoyang Chen, Kevin Turner, Kyle Gheres, Jinyun Liu, Bruce J. Gluckman, Patrick Drew, Sri Rajasekhar Kothapalli, 2022, Optics Letters on p. 1121-1124

Could respiration-driven blood oxygen changes modulate neural activity?

Qingguang Zhang, William D. Haselden, Serge Charpak, Patrick J. Drew, 2022, Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere

Cerebral Oxygenation Dynamics in Awake Behaving Mice

Qingguang Zhang, Morgane Roche, Kyle W. Gheres, Emmanuelle Chaigneau, William D. Haselden, Ravi T. Kedarasetti, Serge Charpak, Patrick J. Drew, 2022,

Most-Cited Papers

Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal

Yu Rong Gao, Yuncong Ma, Qingguang Zhang, Aaron T. Winder, Zhifeng Liang, Lilith Antinori, Patrick J. Drew, Nanyin Zhang, 2017, NeuroImage on p. 382-398

Weak correlations between hemodynamic signals and ongoing neural activity during the resting state

Aaron T. Winder, Christina Echagarruga, Qingguang Zhang, Patrick J. Drew, 2017, Nature Neuroscience on p. 1761-1769

Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture

Andy Y. Shih, Charlotta Rühlmann, Pablo Blinder, Anna Devor, Patrick J. Drew, Beth Friedman, Per M. Knutsen, Patrick D. Lyden, Céline Matéo, Lisa Mellander, Nozomi Nishimura, Chris B. Schaffer, Philbert S. Tsai, David Kleinfeld, 2015, Microcirculation on p. 204-218

Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate

Jordan N. Norwood, Qingguang Zhang, David Card, Amanda Craine, Timothy M. Ryan, Patrick J. Drew, 2019, eLife

Neurovascular coupling and decoupling in the cortex during voluntary locomotion

Bing Xing Huo, Jared B. Smith, Patrick J. Drew, 2014, Journal of Neuroscience on p. 10975-10981

Ultra-slow Oscillations in fMRI and Resting-State Connectivity: Neuronal and Vascular Contributions and Technical Confounds

Patrick J. Drew, C Mateo, K Turner, X Yu, D Kleinfeld, 2020, Neuron on p. 782-804

Vascular and neural basis of the BOLD signal

Patrick J. Drew, 2019, Current Opinion in Neurobiology on p. 61-69

Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response

Yu Rong Gao, Stephanie E. Greene, Patrick J. Drew, 2015, NeuroImage on p. 162-176

Arterial pulsations drive oscillatory flow of CSF but not directional pumping

Ravi Kedarasetti, Patrick J. Drew, Francesco Costanzo, 2020, Scientific Reports on p. 10:10102-1–10:10102-12

Quantitative separation of arterial and venous cerebral blood volume increases during voluntary locomotion

Bing Xing Huo, Yu Rong Gao, Patrick J. Drew, 2015, NeuroImage on p. 369-379

News Articles Featuring Patrick Drew

Mar 03, 2022

Researchers publish how-to guide for monitoring and analyzing brain activity

Penn State researchers have developed a set of tools and methods to better monitor and analyze sleep-related signals and fidgeting in rodent brain studies. Considered the bedrock of biomedical research, rodent studies often provide the first advanced understanding of brain activity and are the foundation on which human studies are eventually built.

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Jan 18, 2021

Increased blood flow during sleep tied to critical brain function

Our brains experience significant changes in blood flow and neural activity during sleep, according to Penn State researchers. Such changes may help to clean out metabolic brain waste that builds up during the day.

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Dec 16, 2020

Some neurons target tiny cerebral blood vessel dilation

Neurons control blood flow in tiny vessels in the brain, but researchers know little about this relationship. Now a team of Penn State engineers has found a connection between nitric oxide expressing neurons and changes in arterial diameters in mice, which may shed light on brain function and aging.

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Dec 05, 2019

Want to Increase Brain Oxygenation? Locomotion May Be Key

Sometimes, it takes neuroscientists much longer than one might expect to substantiate everyday observations that seem like common sense.

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Dec 04, 2019

Respiration key to increase oxygen in the brain

Contrary to accepted knowledge, blood can bring more oxygen to mice brains when they exercise because the increased respiration packs more oxygen into the hemoglobin, according to an international team of researchers who believe that this holds true for all mammals.

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Sep 24, 2019

Patrick Drew named associate director of Penn State’s Neuroscience Institute

Drew succeeds David Vandenbergh in an important role promoting Neuroscience research and education at University Park.

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Jul 01, 2019

Sense of smell, pollution and neurological disease connection explored

A consensus is building that air pollution can cause neurological diseases such as Alzheimer's disease and Parkinson's disease, but how fine, sooty particles cause problems in the brain is still an unanswered question. Now a team of Penn State researchers, using mice, have found a possible way, but more research is still needed.

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May 07, 2019

Institutes of Energy and the Environment announces seed grant recipients

Several Huck researchers are among the recipients of 2018-19 IEE seed grants.

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