Melissa Rolls
Chair, Intercollege Graduate Degree Program in Molecular, Cellular, and Integrative Biosciences; Director of the Center for Cellular Dynamics; Paul Berg Professor of Biochemistry and Molecular Biology

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118 Huck Life Sciences
University Park, PA 16802 - mur22@psu.edu
- 814-867-1395
Research Summary
Subcellular compartmentalization of neurons. The cellular basis of neuronal polarity and neuronal responses to injury including degeneration and regeneration.
Huck Graduate Students
- Richard Albertson
- Chengye Feng
- Pankajam Thyagarajan
- Ian Hertzler
- Yitao Shen
- Nitish Kumar
- Maalavika Govindarajan
- Gibarni Mahata
- Shirley Guo
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- Center for Cellular Dynamics
- Neuroscience Institute
- Center for Molecular Investigation of Neurological Disorders
- Neuroscience
Links
Publication Tags
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Dendrites Microtubules Axons Neurons Regeneration Drosophila Genes Wounds And Injuries Tubulin Growth Kinesin Proteins Phosphotransferases Leucine Zippers Vertebrates Mitochondria Dendrites (Metallography) Gene Defects Caspases Leucine Defect Phenotype Brain ZebrafishMost Recent Publications
The exocyst complex is required for developmental and regenerative neurite growth in vivo
Rachel D. Swope, J. Ian Hertzler, Michelle C. Stone, Gregory O. Kothe, Melissa M. Rolls, 2022, Developmental Biology on p. 1-13
The MAP3Ks DLK and LZK Direct Diverse Responses to Axon Damage in Zebrafish Peripheral Neurons
Kadidia Pemba Adula, Matthew Shorey, Vasudha Chauhan, Khaled Nassman, Shu Fan Chen, Melissa M. Rolls, Alvaro Sagasti, 2022, Journal of Neuroscience on p. 6195-6210
Dendrite regeneration in the vertebrate spinal cord
Michelle C. Stone, Dylan Y. Seebold, Matthew Shorey, Gregory O. Kothe, Melissa M. Rolls, 2022, Developmental Biology on p. 114-119
Microtubule polarity is instructive for many aspects of neuronal polarity
Pankajam Thyagarajan, Chengye Feng, David Lee, Matthew Shorey, Melissa M. Rolls, 2022, Developmental Biology on p. 56-70
Principles of microtubule polarity in linear cells
Melissa M. Rolls, 2022, Developmental Biology on p. 112-117
Erratum: Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy (Proceedings of the National Academy of Sciences of the United States of America (2021) 118 (e2012685118) DOI: 10.1073/pnas.2012685118)
Maria Elena Pero, Cristina Meregalli, Xiaoyi Qu, Grace Ji-Eun Shin, Atul Kumar, Matthew Shorey, Melissa M. Rolls, Kurenai Tanji, Thomas H. Brannagan, Paola Alberti, Giulia Fumagalli, Laura Monza, Wesley B. Grueber, Guido Cavaletti, Francesca Bartolini, 2021, Proceedings of the National Academy of Sciences of the United States of America
Microtubule organization of vertebrate sensory neurons in vivo
Matthew Shorey, Kavitha Rao, Michelle C. Stone, Floyd J. Mattie, Alvaro Sagasti, Melissa M. Rolls, 2021, Developmental Biology on p. 1-12
Trim9 and Klp61F promote polymerization of new dendritic microtubules along parallel microtubules
Chengye Feng, Joseph M. Cleary, Gregory O. Kothe, Michelle C. Stone, Alexis T. Weiner, James I. Hertzler, William O. Hancock, Melissa M. Rolls, 2021, The Quarterly journal of microscopical science
To nucleate or not, that is the question in neurons
Alexis T. Weiner, Pankajam Thyagarajan, Yitao Shen, Melissa M. Rolls, 2021, Neuroscience Letters
Functional assessment of the "two-hit" model for neurodevelopmental defects in drosophila and x. laevis
Pizzo Lucilla, Lasser Micaela, Yusuff Tanzeen, Jensen Matthew, Ingraham Phoebe, Huber Emily, Dhruba Singh Mayanglambam, Monahan Connor, Iyer Janani, Desai Inshya, Karthikeyan Siddharth, J. Gould Dagny, Yennawar Sneha, T. Weiner I. Alexis, Kumar Pounraja Vijay, Krishnan Arjun, M. Rolls Melissa, Anne Lowery Laura, Girirajan Santhosh, 2021, PLoS Genetics
Most-Cited Papers
γ-tubulin controls neuronal microtubule polarity independently of Golgi outposts
Michelle M. Nguyen, Christie J. McCracken, E. S. Milner, Daniel J. Goetschius, Alexis T. Weiner, Melissa K. Long, Nick L. Michael, Sean Munro, Melissa M. Rolls, 2014, Molecular Biology of the Cell on p. 2039-2050
Dendrite injury triggers DLK-independent regeneration
Michelle C. Stone, Richard M. Albertson, Li Chen, Melissa M. Rolls, 2014, Cell Reports on p. 247-253
Neuronal polarity: An evolutionary perspective
Melissa M. Rolls, Timothy J. Jegla, 2015, Journal of Experimental Biology on p. 572-580
Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration
Kavitha Rao, Michelle C. Stone, Alexis T. Weiner, Kyle W. Gheres, Chaoming Zhou, David L. Deitcher, Edwin S. Levitan, Melissa M. Rolls, 2016, Molecular Biology of the Cell on p. 3245-3256
Patronin-mediated minus end growth is required for dendritic microtubule polarity
Chengye Feng, Pankajam Thyagarajan, Matthew Shorey, Dylan Y. Seebold, Alexis T. Weiner, Richard M. Albertson, Kavitha S. Rao, Alvaro Sagasti, Daniel J. Goetschius, Melissa M. Rolls, 2019, Journal of Cell Biology on p. 2309-2328
Pervasive genetic interactions modulate neurodevelopmental defects of the autism-Associated 16p11.2 deletion in Drosophila melanogaster
Janani Iyer, Mayanglambam Dhruba Singh, Matthew Jensen, Payal Patel, Lucilla Pizzo, Emily Huber, Haley Koerselman, Alexis T. Weiner, Paola Lepanto, Komal Vadodaria, Alexis Kubina, Qingyu Wang, Abigail Talbert, Sneha Yennawar, Jose Badano, J. Robert Manak, Melissa M. Rolls, Arjun Krishnan, Santhosh Girirajan, 2018, Nature Communications
Endosomal Wnt signaling proteins control microtubule nucleation in dendrites
Alexis T. Weiner, Dylan Y. Seebold, Pedro Torres-Gutierrez, Christin Folker, Rachel D. Swope, Gregory O. Kothe, Jessica G. Stoltz, Madeleine K. Zalenski, Christopher Kozlowski, Dylan J. Barbera, Mit A. Patel, Pankajam Thyagarajan, Matthew Shorey, Derek M.R. Nye, Matthew Keegan, Kana Behari, Song Song, Jeffrey D. Axelrod, Melissa M. Rolls, 2020, PLoS Biology
The microtubule-severing protein fidgetin acts after dendrite injury to promote their degeneration
Juan Tao, Chengye Feng, Melissa M. Rolls, 2016, The Quarterly journal of microscopical science on p. 3274-3281
Mitochondria and Caspases Tune Nmnat-Mediated Stabilization to Promote Axon Regeneration
Li Chen, Derek M. Nye, Michelle C. Stone, Alexis T. Weiner, Kyle W. Gheres, Xin Xiong, Catherine A. Collins, Melissa M. Rolls, 2016, PLoS Genetics
An EB1-kinesin complex is sufficient to steer microtubule growth in vitro
Yalei Chen, Melissa M. Rolls, William O. Hancock, 2014, Current Biology on p. 316-321
News Articles Featuring Melissa Rolls
Apr 20, 2023
Grad Students in Huck Labs Win Awards for Innovative Research
Two graduate students—one in the Huck's Neuroscience program and the other in the Eberly College of Science's BMMB program—have been named recipients of an award available to those working in Biochemistry and Molecular Biology labs. Both PIs are also part of the Huck.
Full Article
Apr 22, 2021
MCIBS head Melissa Rolls honored with 2021 Graduate Program Chair Leadership Award
Melissa Rolls, Paul Berg Professor of Biochemistry and Molecular Biology, in the Eberly College of Science, is the 2021 recipient of Penn State's Graduate School Alumni Society Graduate Program Chair Leadership Award.
Full Article
Feb 15, 2021
MCIBS Chair Melissa Rolls Wins Leadership Award
Melissa Rolls, who is also the Paul Berg Professor of Biochemistry and Molecular Biology and the Director of the Center for Cellular Dynamics, has been recognized for outstanding leadership of the Molecular, Cellular, and Integrative Biosciences graduate program.
Full Article
Sep 25, 2019
Melissa Rolls appointed Paul Berg Professor of Biochemistry
Melissa Rolls, professor of biochemistry and molecular biology, has been named the Paul Berg Professor of Biochemistry. The professorship was created in 1995 by an anonymous donor in honor of Paul Berg, a 1948 Penn State graduate who was named a Distinguished Alumnus in 1974 and earned the Nobel Prize in 1980 for developing a method to map the structure and function of DNA.
Full Article