Melissa Rolls

Chair, Intercollege Graduate Degree Program in Molecular, Cellular and Integrative Biosciences; Co-Director of the Center for Cellular Dynamics; Paul Berg Professor of Biochemistry and Molecular Biology

Melissa Rolls

Research Summary

Subcellular compartmentalization of neurons. The cellular basis of neuronal polarity and neuronal responses to injury including degeneration and regeneration.

Huck Graduate Students

Huck Affiliations


Publication Tags

Neurons Dendrites Axons Microtubules Drosophila Proteins Wounds And Injuries Tubulin Regeneration Dendrites (Metallography) Protein Phosphotransferases Genes Nervous System Spastin Leucine Zippers Neurites Sensory Receptor Cells Microtubule Proteins Brain Growth Nucleation Xenopus Laevis Wnt Proteins Receptors

Most Recent Papers

To nucleate or not, that is the question in neurons

Alexis T. Weiner, Pankajam Thyagarajan, Yitao Shen, Melissa M. Rolls, 2021, Neuroscience Letters

Functional assessment of the "two-hit" model for neurodevelopmental defects in Drosophila and X. laevis

Lucilla Pizzo, Micaela Lasser, Tanzeen Yusuff, Matthew Jensen, Phoebe Ingraham, Emily Huber, Mayanglambam Dhruba Singh, Connor Monahan, Janani Iyer, Inshya Desai, Siddharth Karthikeyan, Dagny J. Gould, Sneha Yennawar, Alexis T. Weiner, Vijay Kumar Pounraja, Arjun Krishnan, Melissa M. Rolls, Laura Anne Lowery, Santhosh Girirajan, 2021, PLoS Genetics on p. e1009112

Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy

Maria Elena Pero, Cristina Meregalli, Xiaoyi Qu, Grace Ji Eun Shin, Atul Kumar, Matthew Shorey, Melissa M. Rolls, Kurenai Tanji, Thomas H. Brannagan, Paola Alberti, Giulia Fumagalli, Laura Monza, Wesley B. Grueber, Guido Cavaletti, Francesca Bartolini, 2021, Proceedings of the National Academy of Sciences of the United States of America

Cytoskeletal and synaptic polarity of LWamide-like+ ganglion neurons in the sea anemone Nematostella vectensis

Michelle C. Stone, Gregory O. Kothe, Melissa M. Rolls, Timothy Jegla, 2020, Journal of Experimental Biology

Neurons survive simultaneous injury to axons and dendrites and regrow both types of processes in vivo

Matthew Shorey, Michelle C. Stone, Jenna Mandel, Melissa M. Rolls, 2020, Developmental Biology on p. 108-118

Kinetochore proteins suppress neuronal microtubule dynamics and promote dendrite regeneration

James I. Hertzler, Samantha I. Simonovitch, Richard M. Albertson, Alexis T. Weiner, Derek M.R. Nye, Melissa M. Rolls, 2020, Molecular Biology of the Cell on p. 2125-2138

The receptor tyrosine kinase Ror is required for dendrite regeneration in Drosophila neurons

Derek M.R. Nye, Richard M. Albertson, Alexis T. Weiner, J. Ian Hertzler, Matthew Shorey, Deborah C.I. Goberdhan, Clive Wilson, Kevin A. Janes, Melissa M. Rolls, 2020, PLoS Biology

Endosomal Wnt signaling proteins control microtubule nucleation in dendrites

Alexis T. Weiner, Dylan Y. Seebold, Pedro Torres-Gutierrez, Christin Folker, Rachel D. Swope, Gregory O. Kothe, Jessica G. Stoltz, Madeleine K. Zalenski, Christopher Kozlowski, Dylan J. Barbera, Mit A. Patel, Pankajam Thyagarajan, Matthew Shorey, Derek M.R. Nye, Matthew Keegan, Kana Behari, Song Song, Jeffrey D. Axelrod, Melissa M. Rolls, 2020, PLoS Biology

Microtubule dynamics in healthy and injured neurons

Melissa M. Rolls, Pankajam Thyagarajan, Chengye Feng, 2020, Developmental Neurobiology

Degeneration of Injured Axons and Dendrites Requires Restraint of a Protective JNK Signaling Pathway by the Transmembrane Protein Raw

Yan Hao, Thomas J. Waller, Derek M. Nye, Jiaxing Li, Yanxiao Zhang, Richard I. Hume, Melissa M. Rolls, Catherine A. Collins, 2019, Journal of Neuroscience on p. 8457-8470

Most-Cited Papers

γ-tubulin controls neuronal microtubule polarity independently of Golgi outposts

Michelle M. Nguyen, Christie J. McCracken, E. S. Milner, Daniel J. Goetschius, Alexis T. Weiner, Melissa K. Long, Nick L. Michael, Sean Munro, Melissa M. Rolls, 2014, Molecular Biology of the Cell on p. 2039-2050

Neuronal polarity in Drosophila

Melissa M. Rolls, 2011, Developmental Neurobiology on p. 419-429

Axon injury and stress trigger a microtubule-based neuroprotective pathway

Li Chen, Michelle C. Stone, Juan Tao, Melissa M. Rolls, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. 11842-11847

Microtubules are organized independently of the centrosome in Drosophila neurons

Michelle M. Nguyen, Michelle C. Stone, Melissa M. Rolls, 2011, Neural Development

Normal Spastin Gene Dosage Is Specifically Required for Axon Regeneration

Michelle C. Stone, Kavitha Rao, Kyle W. Gheres, Seahee Kim, Juan Tao, Caroline La Rochelle, Christin T. Folker, Nina T. Sherwood, Melissa M. Rolls, 2012, Cell Reports on p. 1340-1350

Dendrites have a rapid program of injury-induced degeneration that is molecularly distinct from developmental pruning

Juan Tao, Melissa M. Rolls, 2011, Journal of Neuroscience on p. 5398-5405

Dendrite injury triggers DLK-independent regeneration

Michelle C. Stone, Richard M. Albertson, Li Chen, Melissa M. Rolls, 2014, Cell Reports on p. 247-253

Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila

Andrea Stewart, Asako Tsubouchi, Melissa M. Rolls, W. Daniel Tracey, Nina Tang Sherwood, 2012, Journal of Neuroscience on p. 11631-11642

Neuronal polarity

Melissa M. Rolls, Timothy J. Jegla, 2015, Journal of Experimental Biology on p. 572-580

Development of dendrite polarity in Drosophila neurons

Sarah E. Hill, Manpreet Parmar, Kyle W. Gheres, Michelle A. Guignet, Yanmei Huang, F. R. Jackson, Melissa M. Rolls, 2012, Neural Development