Melissa Rolls

Chair, Intercollege Graduate Degree Program in Molecular, Cellular and Integrative Biosciences; Director of the Center for Cellular Dynamics; Paul Berg Professor of Biochemistry and Molecular Biology

Melissa Rolls

Research Summary

Subcellular compartmentalization of neurons. The cellular basis of neuronal polarity and neuronal responses to injury including degeneration and regeneration.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Dendrites Neurons Microtubules Axons Drosophila Proteins Regeneration Wounds And Injuries Spastin Tubulin Genes Dendrites (Metallography) Phosphotransferases Growth Leucine Zippers Defects Mitochondria Microtubule Proteins Sensory Receptor Cells Rna Interference Nucleation Wnt Proteins Drosophila Melanogaster Receptor Protein Tyrosine Kinases Receptor Tyrosine Kinase Like Orphan Receptors

Most Recent Papers

Neurons survive simultaneous injury to axons and dendrites and regrow both types of processes in vivo

Matthew Shorey, Michelle C. Stone, Jenna Mandel, Melissa M. Rolls, 2020, Developmental Biology on p. 108-118

Kinetochore proteins suppress neuronal microtubule dynamics and promote dendrite regeneration

James I. Hertzler, Samantha I. Simonovitch, Richard M. Albertson, Alexis T. Weiner, Derek M.R. Nye, Melissa M. Rolls, 2020, Molecular Biology of the Cell on p. 2125-2138

Microtubule dynamics in healthy and injured neurons.

Melissa Rolls, P Thyagarajan, C Feng, 2020, Developmental neurobiology

Endosomal Wnt signaling proteins control microtubule nucleation in dendrites

Alexis T. Weiner, Dylan Y. Seebold, Pedro Torres-Gutierrez, Christin Folker, Rachel D. Swope, Gregory O. Kothe, Jessica G. Stoltz, Madeleine K. Zalenski, Christopher Kozlowski, Dylan J. Barbera, Mit A. Patel, Pankajam Thyagarajan, Matthew Shorey, Derek M.R. Nye, Matthew Keegan, Kana Behari, Song Song, Jeffrey D. Axelrod, Melissa M. Rolls, 2020, PLoS Biology

The receptor tyrosine kinase Ror is required for dendrite regeneration in Drosophila neurons

Derek M.R. Nye, Richard M. Albertson, Alexis T. Weiner, J. Ian Hertzler, Matthew Shorey, Deborah C.I. Goberdhan, Clive Wilson, Kevin A. Janes, Melissa M. Rolls, 2020, PLoS Biology

Cytoskeletal and synaptic polarity of LWamide-like plus ganglion neurons in the sea anemone Nematostella vectensis

Michelle Stone, Gregory Kothe, Melissa Rolls, Timothy Jegla, 2020, JOURNAL OF EXPERIMENTAL BIOLOGY

Degeneration of Injured Axons and Dendrites Requires Restraint of a Protective JNK Signaling Pathway by the Transmembrane Protein Raw

Yan Hao, Thomas J. Waller, Derek M. Nye, Jiaxing Li, Yanxiao Zhang, Richard I. Hume, Melissa M. Rolls, Catherine A. Collins, 2019, Journal of Neuroscience on p. 8457-8470

Patronin-mediated minus end growth is required for dendritic microtubule polarity

Chengye Feng, Pankajam Thyagarajan, Matthew Shorey, Dylan Y. Seebold, Alexis T. Weiner, Richard M. Albertson, Kavitha S. Rao, Alvaro Sagasti, Daniel J. Goetschius, Melissa M. Rolls, 2019, Journal of Cell Biology on p. 2309-2328

Pervasive genetic interactions modulate neurodevelopmental defects of the autism-Associated 16p11.2 deletion in Drosophila melanogaster

Janani Iyer, Mayanglambam Dhruba Singh, Matthew Jensen, Payal Patel, Lucilla Pizzo, Emily Huber, Haley Koerselman, Alexis T. Weiner, Paola Lepanto, Komal Vadodaria, Alexis Kubina, Qingyu Wang, Abigail Talbert, Sneha Yennawar, Jose Badano, J. Robert Manak, Melissa Rolls, Arjun Krishnan, Santhosh Girirajan, 2018, Nature Communications

Identification of proteins required for precise positioning of Apc2 in dendrites

Alexis T. Weiner, Dylan Y. Seebold, Nick L. Michael, Michelle Guignet, Chengye Feng, Brandon Follick, Brandon A. Yusko, Nathan P. Wasilko, Pedro Torres-Gutierrez, Melissa M. Rolls, 2018, G3: Genes, Genomes, Genetics on p. 1841-1853

Most-Cited Papers

Neuronal polarity in Drosophila

Melissa Rolls, 2011, Developmental Neurobiology on p. 419-429

γ-tubulin controls neuronal microtubule polarity independently of Golgi outposts

Michelle M. Nguyen, Christie J. McCracken, E. S. Milner, Daniel J. Goetschius, Alexis T. Weiner, Melissa K. Long, Nick L. Michael, Sean Munro, Melissa Rolls, 2014, Molecular Biology of the Cell on p. 2039-2050

Axon injury and stress trigger a microtubule-based neuroprotective pathway

Li Chen, Michelle C. Stone, Juan Tao, Melissa Rolls, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. 11842-11847

Microtubules are organized independently of the centrosome in Drosophila neurons

Michelle M. Nguyen, Michelle C. Stone, Melissa M. Rolls, 2011, Neural Development

Dendrites have a rapid program of injury-induced degeneration that is molecularly distinct from developmental pruning

Juan Tao, Melissa M. Rolls, 2011, Journal of Neuroscience on p. 5398-5405

Normal Spastin Gene Dosage Is Specifically Required for Axon Regeneration

Michelle C. Stone, Kavitha Rao, Kyle W. Gheres, Seahee Kim, Juan Tao, Caroline La Rochelle, Christin T. Folker, Nina T. Sherwood, Melissa Rolls, 2012, Cell Reports on p. 1340-1350

Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila

Andrea Stewart, Asako Tsubouchi, Melissa M. Rolls, W. Daniel Tracey, Nina Tang Sherwood, 2012, Journal of Neuroscience on p. 11631-11642

Dendrite injury triggers DLK-independent regeneration

Michelle C. Stone, Richard M. Albertson, Li Chen, Melissa Rolls, 2014, Cell Reports on p. 247-253

Development of dendrite polarity in Drosophila neurons

Sarah E. Hill, Manpreet Parmar, Kyle W. Gheres, Michelle A. Guignet, Yanmei Huang, F. R. Jackson, Melissa M. Rolls, 2012, Neural Development

Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration

Kavitha Rao, Michelle C. Stone, Alexis T. Weiner, Kyle W. Gheres, Chaoming Zhou, David L. Deitcher, Edwin S. Levitan, Melissa Rolls, 2016, Molecular Biology of the Cell on p. 3245-3256