Melissa Rolls

Chair, Intercollege Graduate Degree Program in Molecular, Cellular and Integrative Biosciences; Co-Director of the Center for Cellular Dynamics; Paul Berg Professor of Biochemistry and Molecular Biology

Melissa Rolls

Research Summary

Subcellular compartmentalization of neurons. The cellular basis of neuronal polarity and neuronal responses to injury including degeneration and regeneration.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Neurons Dendrites Axons Microtubules Drosophila Regeneration Genes Spastin Wounds And Injuries Tubulin Nervous System Proteins Growth Sensory Receptor Cells Dendrites (Metallography) Protein Phosphotransferases Leucine Zippers Defect Gene Defects Neurites Vertebrates Phenotype Brain

Most Recent Papers

Erratum

Maria Elena Pero, Cristina Meregalli, Xiaoyi Qu, Grace Ji-Eun Shin, Atul Kumar, Matthew Shorey, Melissa M. Rolls, Kurenai Tanji, Thomas H. Brannagan, Paola Alberti, Giulia Fumagalli, Laura Monza, Wesley B. Grueber, Guido Cavaletti, Francesca Bartolini, 2021, Proceedings of the National Academy of Sciences of the United States of America

Microtubule organization of vertebrate sensory neurons in vivo

Matthew Shorey, Kavitha Rao, Michelle C. Stone, Floyd J. Mattie, Alvaro Sagasti, Melissa M. Rolls, 2021, Developmental Biology on p. 1-12

Trim9 and Klp61F promote polymerization of new dendritic microtubules along parallel microtubules

Chengye Feng, Joseph M. Cleary, Gregory O. Kothe, Michelle C. Stone, Alexis T. Weiner, James I. Hertzler, William O. Hancock, Melissa M. Rolls, 2021, The Quarterly journal of microscopical science

To nucleate or not, that is the question in neurons

Alexis T. Weiner, Pankajam Thyagarajan, Yitao Shen, Melissa M. Rolls, 2021, Neuroscience Letters

Functional assessment of the "two-hit" model for neurodevelopmental defects in drosophila and x. laevis

Pizzo Lucilla, Lasser Micaela, Yusuff Tanzeen, Jensen Matthew, Ingraham Phoebe, Huber Emily, Dhruba Singh Mayanglambam, Monahan Connor, Iyer Janani, Desai Inshya, Karthikeyan Siddharth, J. Gould Dagny, Yennawar Sneha, T. Weiner I. Alexis, Kumar Pounraja Vijay, Krishnan Arjun, M. Rolls Melissa, Anne Lowery Laura, Girirajan Santhosh, 2021, PLoS Genetics

Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy

Maria Elena Pero, Cristina Meregalli, Xiaoyi Qu, Grace Ji Eun Shin, Atul Kumar, Matthew Shorey, Melissa M. Rolls, Kurenai Tanji, Thomas H. Brannagan, Paola Alberti, Giulia Fumagalli, Laura Monza, Wesley B. Grueber, Guido Cavaletti, Francesca Bartolini, 2021, Proceedings of the National Academy of Sciences of the United States of America

Cytoskeletal and synaptic polarity of LWamide-like+ ganglion neurons in the sea anemone Nematostella vectensis

Michelle C. Stone, Gregory O. Kothe, Melissa M. Rolls, Timothy Jegla, 2020, Journal of Experimental Biology

Neurons survive simultaneous injury to axons and dendrites and regrow both types of processes in vivo

Matthew Shorey, Michelle C. Stone, Jenna Mandel, Melissa M. Rolls, 2020, Developmental Biology on p. 108-118

Kinetochore proteins suppress neuronal microtubule dynamics and promote dendrite regeneration

James I. Hertzler, Samantha I. Simonovitch, Richard M. Albertson, Alexis T. Weiner, Derek M.R. Nye, Melissa M. Rolls, 2020, Molecular Biology of the Cell on p. 2125-2138

The receptor tyrosine kinase Ror is required for dendrite regeneration in Drosophila neurons

Derek M.R. Nye, Richard M. Albertson, Alexis T. Weiner, J. Ian Hertzler, Matthew Shorey, Deborah C.I. Goberdhan, Clive Wilson, Kevin A. Janes, Melissa M. Rolls, 2020, PLoS Biology

Most-Cited Papers

γ-tubulin controls neuronal microtubule polarity independently of Golgi outposts

Michelle M. Nguyen, Christie J. McCracken, E. S. Milner, Daniel J. Goetschius, Alexis T. Weiner, Melissa K. Long, Nick L. Michael, Sean Munro, Melissa M. Rolls, 2014, Molecular Biology of the Cell on p. 2039-2050

Axon injury and stress trigger a microtubule-based neuroprotective pathway

Li Chen, Michelle C. Stone, Juan Tao, Melissa M. Rolls, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. 11842-11847

Normal Spastin Gene Dosage Is Specifically Required for Axon Regeneration

Michelle C. Stone, Kavitha Rao, Kyle W. Gheres, Seahee Kim, Juan Tao, Caroline La Rochelle, Christin T. Folker, Nina T. Sherwood, Melissa M. Rolls, 2012, Cell Reports on p. 1340-1350

Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila

Andrea Stewart, Asako Tsubouchi, Melissa M. Rolls, W. Daniel Tracey, Nina Tang Sherwood, 2012, Journal of Neuroscience on p. 11631-11642

Dendrite injury triggers DLK-independent regeneration

Michelle C. Stone, Richard M. Albertson, Li Chen, Melissa M. Rolls, 2014, Cell Reports on p. 247-253

Neuronal polarity

Melissa M. Rolls, Timothy J. Jegla, 2015, Journal of Experimental Biology on p. 572-580

Development of dendrite polarity in Drosophila neurons

Sarah E. Hill, Manpreet Parmar, Kyle W. Gheres, Michelle A. Guignet, Yanmei Huang, F. R. Jackson, Melissa M. Rolls, 2012, Neural Development

Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration

Kavitha Rao, Michelle C. Stone, Alexis T. Weiner, Kyle W. Gheres, Chaoming Zhou, David L. Deitcher, Edwin S. Levitan, Melissa M. Rolls, 2016, Molecular Biology of the Cell on p. 3245-3256

Patronin-mediated minus end growth is required for dendritic microtubule polarity

Chengye Feng, Pankajam Thyagarajan, Matthew Shorey, Dylan Y. Seebold, Alexis T. Weiner, Richard M. Albertson, Kavitha S. Rao, Alvaro Sagasti, Daniel J. Goetschius, Melissa M. Rolls, 2019, Journal of Cell Biology on p. 2309-2328

Pervasive genetic interactions modulate neurodevelopmental defects of the autism-Associated 16p11.2 deletion in Drosophila melanogaster

Janani Iyer, Mayanglambam Dhruba Singh, Matthew Jensen, Payal Patel, Lucilla Pizzo, Emily Huber, Haley Koerselman, Alexis T. Weiner, Paola Lepanto, Komal Vadodaria, Alexis Kubina, Qingyu Wang, Abigail Talbert, Sneha Yennawar, Jose Badano, J. Robert Manak, Melissa M. Rolls, Arjun Krishnan, Santhosh Girirajan, 2018, Nature Communications