Melissa Rolls

Chair, Intercollege Graduate Degree Program in Molecular, Cellular and Integrative Biosciences; Director of the Center for Cellular Dynamics; Professor of Biochemistry and Molecular Biology

Melissa Rolls

Research Summary

Subcellular compartmentalization of neurons. The cellular basis of neuronal polarity and neuronal responses to injury including degeneration and regeneration.

Graduate Students

Huck Affiliations


Publication Tags

Dendrites Axons Microtubules Neurons Drosophila Regeneration Wounds And Injuries Proteins Kinesin Growth Genes Mitochondria Phosphotransferases Microtubule Proteins Caspases Nicotinamide Leucine Zippers Ankyrins Defects Niacinamide Sensory Receptor Cells Tubulin Neuronal Plasticity Drosophila Melanogaster Cell Proliferation

Most Recent Papers

Degeneration of Injured Axons and Dendrites Requires Restraint of a Protective JNK Signaling Pathway by the Transmembrane Protein Raw

Yan Hao, Thomas J. Waller, Derek M. Nye, Jiaxing Li, Yanxiao Zhang, Richard I. Hume, Melissa M. Rolls, Catherine A. Collins, 2019, The Journal of neuroscience : the official journal of the Society for Neuroscience on p. 8457-8470

Patronin-mediated minus end growth is required for dendritic microtubule polarity

Chengye Feng, Pankajam Thyagarajan, Matthew Shorey, Dylan Y. Seebold, Alexis T. Weiner, Richard M. Albertson, Kavitha S. Rao, Alvaro Sagasti, Daniel J. Goetschius, Melissa M. Rolls, 2019, Journal of Cell Biology on p. 2309-2328

Pervasive genetic interactions modulate neurodevelopmental defects of the autism-Associated 16p11.2 deletion in Drosophila melanogaster

Janani Iyer, Mayanglambam Dhruba Singh, Matthew Jensen, Payal Patel, Lucilla Pizzo, Emily Huber, Haley Koerselman, Alexis T. Weiner, Paola Lepanto, Komal Vadodaria, Alexis Kubina, Qingyu Wang, Abigail Talbert, Sneha Yennawar, Jose Badano, J. Robert Manak, Melissa Rolls, Arjun Krishnan, Santhosh Girirajan, 2018, Nature communications

Identification of proteins required for precise positioning of Apc2 in dendrites

Alexis T. Weiner, Dylan Y. Seebold, Nick L. Michael, Michelle Guignet, Chengye Feng, Brandon Follick, Brandon A. Yusko, Nathan P. Wasilko, Pedro Torres-Gutierrez, Melissa M. Rolls, 2018, G3: Genes, Genomes, Genetics on p. 1841-1853

Two Drosophila model neurons can regenerate axons from the stump or from a converted dendrite, with feedback between the two sites

Kavitha S. Rao, Melissa Rolls, 2017, Neural Development

Mitochondria and Caspases Tune Nmnat-Mediated Stabilization to Promote Axon Regeneration

Li Chen, Derek M. Nye, Michelle C. Stone, Alexis T. Weiner, Kyle W. Gheres, Xin Xiong, Catherine A. Collins, Melissa Rolls, 2016, PLoS genetics

Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment

Timothy J. Jegla, Michelle M. Nguyen, Chengye Feng, Daniel J. Goetschius, Esteban Luna, Damian B. Van Rossum, Bishoy Kamel, Aditya Pisupati, Elliott S. Milner, Melissa Rolls, 2016, PLoS genetics

Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration

Kavitha Rao, Michelle C. Stone, Alexis T. Weiner, Kyle W. Gheres, Chaoming Zhou, David L. Deitcher, Edwin S. Levitan, Melissa Rolls, 2016, Molecular Biology of the Cell on p. 3245-3256

Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel

Awani Upadhyay, Aditya Pisupati, Timothy Jegla, Matt Crook, Keith J. Mickolajczyk, Matthew Shorey, Laura E. Rohan, Katherine A. Billings, Melissa M. Rolls, William O. Hancock, Wendy Hanna-Rose, 2016, Nature communications

The microtubule-severing protein fidgetin acts after dendrite injury to promote their degeneration

Juan Tao, Chengye Feng, Melissa Rolls, 2016, Journal of Cell Science on p. 3274-3281

Most-Cited Papers

Global up-regulation of microtubule dynamics and polarity reversal during regeneration of an axon from a dendrite

Michelle C. Stone, Michelle M. Nguyen, Juan Tao, Dana L. Allender, Melissa Rolls, 2010, Molecular Biology of the Cell on p. 767-777

Directed microtubule growth, +TIPs, and Kinesin-2 Are required for uniform microtubule polarity in dendrites

Floyd J. Mattie, Megan M. Stackpole, Michelle C. Stone, Jessie R. Clippard, David A. Rudnick, Yijun Qiu, Juan Tao, Dana L. Allender, Manpreet Parmar, Melissa M. Rolls, 2010, Current Biology on p. 2169-2177

Neuronal polarity in Drosophila

Melissa Rolls, 2011, Developmental Neurobiology on p. 419-429

γ-tubulin controls neuronal microtubule polarity independently of Golgi outposts

Michelle M. Nguyen, Christie J. McCracken, E. S. Milner, Daniel J. Goetschius, Alexis T. Weiner, Melissa K. Long, Nick L. Michael, Sean Munro, Melissa Rolls, 2014, Molecular Biology of the Cell on p. 2039-2050

Dendrites have a rapid program of injury-induced degeneration that is molecularly distinct from developmental pruning

Juan Tao, Melissa M. Rolls, 2011, Journal of Neuroscience on p. 5398-5405

Axon injury and stress trigger a microtubule-based neuroprotective pathway

Li Chen, Michelle C. Stone, Juan Tao, Melissa Rolls, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. 11842-11847

Microtubules are organized independently of the centrosome in Drosophila neurons

Michelle M. Nguyen, Michelle C. Stone, Melissa M. Rolls, 2011, Neural Development

Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila

Andrea Stewart, Asako Tsubouchi, Melissa M. Rolls, W. Daniel Tracey, Nina Tang Sherwood, 2012, Journal of Neuroscience on p. 11631-11642

Normal Spastin Gene Dosage Is Specifically Required for Axon Regeneration

Michelle C. Stone, Kavitha Rao, Kyle W. Gheres, Seahee Kim, Juan Tao, Caroline La Rochelle, Christin T. Folker, Nina T. Sherwood, Melissa Rolls, 2012, Cell Reports on p. 1340-1350

Dendrite injury triggers DLK-independent regeneration

Michelle C. Stone, Richard M. Albertson, Li Chen, Melissa Rolls, 2014, Cell Reports on p. 247-253