Melissa Rolls

Chair, Intercollege Graduate Degree Program in Molecular, Cellular and Integrative Biosciences; Co-Director of the Center for Cellular Dynamics; Paul Berg Professor of Biochemistry and Molecular Biology

Melissa Rolls

Research Summary

Subcellular compartmentalization of neurons. The cellular basis of neuronal polarity and neuronal responses to injury including degeneration and regeneration.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Microtubules Dendrites Axons Neurons Drosophila Spastin Kinesin Tubulin Regeneration Growth Genes Nervous System Sensory Receptor Cells Wounds And Injuries Bortezomib Peripheral Nervous System Diseases Phosphotransferases Leucine Zippers Vertebrates Dendrites (Metallography) Neurites Brain Protein Cell Body Proteins

Most Recent Papers

Dendrite regeneration in the vertebrate spinal cord

Michelle C. Stone, Dylan Y. Seebold, Matthew Shorey, Gregory O. Kothe, Melissa M. Rolls, 2022, Developmental Biology on p. 114-119

Microtubule polarity is instructive for many aspects of neuronal polarity

Pankajam Thyagarajan, Chengye Feng, David Lee, Matthew Shorey, Melissa M. Rolls, 2022, Developmental Biology on p. 56-70

Principles of microtubule polarity in linear cells

Melissa M. Rolls, 2022, Developmental Biology on p. 112-117

Erratum

Maria Elena Pero, Cristina Meregalli, Xiaoyi Qu, Grace Ji-Eun Shin, Atul Kumar, Matthew Shorey, Melissa M. Rolls, Kurenai Tanji, Thomas H. Brannagan, Paola Alberti, Giulia Fumagalli, Laura Monza, Wesley B. Grueber, Guido Cavaletti, Francesca Bartolini, 2021, Proceedings of the National Academy of Sciences of the United States of America

Microtubule organization of vertebrate sensory neurons in vivo

Matthew Shorey, Kavitha Rao, Michelle C. Stone, Floyd J. Mattie, Alvaro Sagasti, Melissa M. Rolls, 2021, Developmental Biology on p. 1-12

Trim9 and Klp61F promote polymerization of new dendritic microtubules along parallel microtubules

Chengye Feng, Joseph M. Cleary, Gregory O. Kothe, Michelle C. Stone, Alexis T. Weiner, James I. Hertzler, William O. Hancock, Melissa M. Rolls, 2021, The Quarterly journal of microscopical science

To nucleate or not, that is the question in neurons

Alexis T. Weiner, Pankajam Thyagarajan, Yitao Shen, Melissa M. Rolls, 2021, Neuroscience Letters

Functional assessment of the "two-hit" model for neurodevelopmental defects in drosophila and x. laevis

Pizzo Lucilla, Lasser Micaela, Yusuff Tanzeen, Jensen Matthew, Ingraham Phoebe, Huber Emily, Dhruba Singh Mayanglambam, Monahan Connor, Iyer Janani, Desai Inshya, Karthikeyan Siddharth, J. Gould Dagny, Yennawar Sneha, T. Weiner I. Alexis, Kumar Pounraja Vijay, Krishnan Arjun, M. Rolls Melissa, Anne Lowery Laura, Girirajan Santhosh, 2021, PLoS Genetics

Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy

Maria Elena Pero, Cristina Meregalli, Xiaoyi Qu, Grace Ji Eun Shin, Atul Kumar, Matthew Shorey, Melissa M. Rolls, Kurenai Tanji, Thomas H. Brannagan, Paola Alberti, Giulia Fumagalli, Laura Monza, Wesley B. Grueber, Guido Cavaletti, Francesca Bartolini, 2021, Proceedings of the National Academy of Sciences of the United States of America

Cytoskeletal and synaptic polarity of LWamide-like+ ganglion neurons in the sea anemone Nematostella vectensis

Michelle C. Stone, Gregory O. Kothe, Melissa M. Rolls, Timothy Jegla, 2020, Journal of Experimental Biology

Most-Cited Papers

γ-tubulin controls neuronal microtubule polarity independently of Golgi outposts

Michelle M. Nguyen, Christie J. McCracken, E. S. Milner, Daniel J. Goetschius, Alexis T. Weiner, Melissa K. Long, Nick L. Michael, Sean Munro, Melissa M. Rolls, 2014, Molecular Biology of the Cell on p. 2039-2050

Axon injury and stress trigger a microtubule-based neuroprotective pathway

Li Chen, Michelle C. Stone, Juan Tao, Melissa M. Rolls, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. 11842-11847

Normal Spastin Gene Dosage Is Specifically Required for Axon Regeneration

Michelle C. Stone, Kavitha Rao, Kyle W. Gheres, Seahee Kim, Juan Tao, Caroline La Rochelle, Christin T. Folker, Nina T. Sherwood, Melissa M. Rolls, 2012, Cell Reports on p. 1340-1350

Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila

Andrea Stewart, Asako Tsubouchi, Melissa M. Rolls, W. Daniel Tracey, Nina Tang Sherwood, 2012, Journal of Neuroscience on p. 11631-11642

Dendrite injury triggers DLK-independent regeneration

Michelle C. Stone, Richard M. Albertson, Li Chen, Melissa M. Rolls, 2014, Cell Reports on p. 247-253

Neuronal polarity

Melissa M. Rolls, Timothy J. Jegla, 2015, Journal of Experimental Biology on p. 572-580

Development of dendrite polarity in Drosophila neurons

Sarah E. Hill, Manpreet Parmar, Kyle W. Gheres, Michelle A. Guignet, Yanmei Huang, F. R. Jackson, Melissa M. Rolls, 2012, Neural Development

Patronin-mediated minus end growth is required for dendritic microtubule polarity

Chengye Feng, Pankajam Thyagarajan, Matthew Shorey, Dylan Y. Seebold, Alexis T. Weiner, Richard M. Albertson, Kavitha S. Rao, Alvaro Sagasti, Daniel J. Goetschius, Melissa M. Rolls, 2019, Journal of Cell Biology on p. 2309-2328

Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration

Kavitha Rao, Michelle C. Stone, Alexis T. Weiner, Kyle W. Gheres, Chaoming Zhou, David L. Deitcher, Edwin S. Levitan, Melissa M. Rolls, 2016, Molecular Biology of the Cell on p. 3245-3256

An EB1-kinesin complex is sufficient to steer microtubule growth in vitro

Yalei Chen, Melissa M. Rolls, William O. Hancock, 2014, Current Biology on p. 316-321