Manuel Llinas

Manuel Llinas

Professor of Biochemistry and Molecular Biology

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Most Recent Papers

Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation

Riëtte Van Biljon, Roelof Van Wyk, Heather J. Painter, Lindsey Orchard, Janette Reader, Jandeli Niemand, Manuel Llinás, Lyn Marie Birkholtz, 2019, BMC genomics

The g9a histone methyltransferase inhibitor BIX-01294 modulates gene expression during plasmodium falciparum gametocyte development and transmission

Che Julius Ngwa, Meike Jutta Kiesow, Lindsey Marie Orchard, Afia Farrukh, Manuel Llinás, Gabriele Pradel, 2019, International journal of molecular sciences

Cutting back malaria

Marcus C.S. Lee, Scott E. Lindner, Jose Juan Lopez-Rubio, Manuel Llinás, 2019, Briefings in functional genomics on p. 281-289

Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum

Joost Schalkwijk, Erik L. Allman, Patrick A.M. Jansen, Laura E. De Vries, Julie M.J. Verhoef, Suzanne Jackowski, Peter N.M. Botman, Christien A. Beuckens-Schortinghuis, Karin M.J. Koolen, Judith M. Bolscher, Martijn W. Vos, Karen Miller, Stacy A. Reeves, Helmi Pett, Graham Trevitt, Sergio Wittlin, Christian Scheurer, Sibylle Sax, Christoph Fischli, Iñigo Angulo-Barturen, Mariá Belén Jiménez-Diaz, Gabrielle Josling, Taco W.A. Kooij, Roger Bonnert, Brice Campo, Richard H. Blaauw, Floris P.J.T. Rutjes, Robert W. Sauerwein, Manuel Llinás, Pedro H.H. Hermkens, Koen J. Dechering, 2019, Science Translational Medicine

Identifying the Components of Acidosis in Patients with Severe Plasmodium falciparum Malaria Using Metabolomics

Stije J. Leopold, Aniruddha Ghose, Erik L. Allman, Hugh W.F. Kingston, Amir Hossain, Asok Kumar Dutta, Katherine Plewes, Kesinee Chotivanich, Nicholas P.J. Day, Joel Tarning, Markus Winterberg, Nicholas J. White, Manuel Llinás, Arjen M. Dondorp, 2019, Journal of Infectious Diseases on p. 1766-1776

Plasmodium niemann-pick type C1- related protein is a druggable target required for parasite membrane homeostasis

Eva S. Istvan, Sudipta Das, Suyash Bhatnagar, Josh R. Beck, Edward Owen, Manuel Llinas, Suresh M. Ganesan, Jacquin C. Niles, Elizabeth Winzeler, Akhil B. Vaidya, Daniel E. Goldberg, 2019, eLife

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

Yevgeniya Antonova-Koch, Stephan Meister, Matthew Abraham, Madeline R. Luth, Sabine Ottilie, Amanda K. Lukens, Tomoyo Sakata-Kato, Manu Vanaerschot, Edward Owen, Juan Carlos Jado Rodriguez, Steven P. Maher, Jaeson Calla, David Plouffe, Yang Zhong, Kaisheng Chen, Victor Chaumeau, Amy J. Conway, Case W. McNamara, Maureen Ibanez, Kerstin Gagaring, Fernando Neria Serrano, Korina Eribez, Cullin Mc Lean Taggard, Andrea L. Cheung, Christie Lincoln, Biniam Ambachew, Melanie Rouillier, Dionicio Siegel, François Nosten, Dennis E. Kyle, Francisco Javier Gamo, Yingyao Zhou, Manuel Llinás, David A. Fidock, Dyann F. Wirth, Jeremy Burrows, Brice Campo, Elizabeth A. Winzeler, 2018, Science

Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter

Andrew H. Lee, Satish K. Dhingra, Ian A. Lewis, Maneesh K. Singh, Amila Siriwardana, Seema Dalal, Kelly Rubiano, Matthias S. Klein, Katelynn S. Baska, Sanjeev Krishna, Michael Klemba, Paul D. Roepe, Manuel Llinás, Celia R.S. Garcia, David A. Fidock, 2018, Scientific reports

Lipopeptisomes

Matthew R. Aronson, Andrew W. Simonson, Lindsey M. Orchard, Manuel Llinás, Scott H. Medina, 2018, Acta Biomaterialia on p. 269-277

Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum parasites

Nanika Coetzee, Simone Sidoli, Riëtte Van Biljon, Heather Painter, Manuel Llinás, Benjamin A. Garcia, Lyn Marie Birkholtz, 2017, Scientific reports

Recent Most-Cited Papers

Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network

Germán Plata, Tzu Lin Hsiao, Kellen L. Olszewski, Manuel Llinás, Dennis Vitkup, 2010, Molecular Systems Biology

A Plasmodium falciparum Histone Deacetylase regulates antigenic variation and gametocyte conversion

Bradley I. Coleman, Kristen M. Skillman, Rays H.Y. Jiang, Lauren M. Childs, Lindsey M. Altenhofen, Markus Ganter, Yvette Leung, Ilana Goldowitz, Björn F.C. Kafsack, Matthias Marti, Manuel Llinas, Caroline O. Buckee, Manoj T. Duraisingh, 2014, Cell Host and Microbe on p. 177-186

Genetic investigation of tricarboxylic acid metabolism during the plasmodium falciparum life cycle

Hangjun Ke, Ian A. Lewis, Joanne M. Morrisey, Kyle J. McLean, Suresh M. Ganesan, Heather Jill Painter Ponton, Michael W. Mather, Marcelo Jacobs-Lorena, Manuel Llinas, Akhil B. Vaidya, 2015, Cell Reports on p. 164-174

A tetracycline-repressible transactivator system to study essential genes in malaria parasites

Paco Pino, Sarah Sebastian, Eunbin Arin Kim, Erin Bush, Mathieu Brochet, Katrin Volkmann, Elyse Kozlowski, Manuel Llinás, Oliver Billker, Dominique Soldati-Favre, 2012, Cell Host and Microbe on p. 824-834

Structural Determinants of DNA Binding by a P. falciparum ApiAP2 Transcriptional Regulator

Scott Eugene Lindner, Erandi K. De Silva, James L. Keck, Manuel Llinas, 2010, Journal of Molecular Biology on p. 558-567

Crystal structure of arginase from plasmodium falciparum and implications for l -arginine depletion in malarial infection

Daniel P. Dowling, Monica Ilies, Kellen L. Olszewski, Silvia Portugal, Maria M. Mota, Manuel Llinás, David W. Christianson, 2010, Biochemistry on p. 5600-5608

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development

Janet Storm, Jan Perner, Isabela Aparicio, Eva Maria Patzewitz, Kellen Olszewski, Manuel Llinas, Paul C. Engel, Sylke Müller, 2011, Malaria journal

Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite

Simon A. Cobbold, Joana M. Santos, Alejandro Ochoa, David H. Perlman, Manuel Llinas, 2016, Scientific reports

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities

Serena Pulcini, Henry M. Staines, Andrew H. Lee, Sarah H. Shafik, Guillaume Bouyer, Catherine M. Moore, Daniel A. Daley, Matthew J. Hoke, Lindsey M. Altenhofen, Heather J. Painter, Jianbing Mu, David J.P. Ferguson, Manuel Llinás, Rowena E. Martin, David A. Fidock, Roland A. Cooper, Sanjeev Krishna, 2015, Scientific reports

Targeting NAD <sup>+</sup> metabolism in the human malaria parasite Plasmodium falciparum

Jessica K. O'Hara, Lewis J. Kerwin, Simon A. Cobbold, Jonathan Tai, Thomas A. Bedell, Paul J. Reider, Manuel Llinás, 2014, PloS one