Manuel Llinas

Manuel Llinas

Professor of Biochemistry and Molecular Biology

Visit my Website

Most Recent Papers

Plasmodium niemann-pick type C1- related protein is a druggable target required for parasite membrane homeostasis

Eva S. Istvan, Sudipta Das, Suyash Bhatnagar, Josh R. Beck, Edward Owen, Manuel Llinas, Suresh M. Ganesan, Jacquin C. Niles, Elizabeth Winzeler, Akhil B. Vaidya, Daniel E. Goldberg, 2019, eLife

Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites

Riëtte van Biljon, Jandeli Niemand, Roelof van Wyk, Katherine Clark, Bianca Verlinden, Clarissa Abrie, Hilde von Grüning, Werner Smidt, Annél Smit, Janette Reader, Heather Jill Painter Ponton, Manuel Llinas, Christian Doerig, Lyn Marié Birkholtz, 2018, Scientific reports

Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development

Heather Jill Painter Ponton, Neo Christopher Chung, Aswathy Sebastian, Istvan Albert, John D. Storey, Manuel Llinas, 2018, Nature communications

Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter

Andrew H. Lee, Satish K. Dhingra, Ian A. Lewis, Maneesh K. Singh, Amila Siriwardana, Seema Dalal, Kelly Rubiano, Matthias S. Klein, Katelynn S. Baska, Sanjeev Krishna, Michael Klemba, Paul D. Roepe, Manuel Llinas, Celia R.S. Garcia, David A. Fidock, 2018, Scientific reports

Lipopeptisomes

Matthew R. Aronson, Andrew W. Simonson, Lindsey M. Orchard, Manuel Llinas, Scott H. Medina, 2018, Acta Biomaterialia on p. 269-277

Glycolysis is important for optimal asexual growth and formation of mature tissue cysts by Toxoplasma gondii

Anurag Shukla, Kellen L. Olszewski, Manuel Llinas, Leah M. Rommereim, Barbara A. Fox, David J. Bzik, Dong Xia, Jonathan Wastling, Daniel Beiting, David S. Roos, Dhanasekaran Shanmugam, 2018, International Journal for Parasitology on p. 955-968

A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum

Sandra Bennink, Andreas von Bohl, Che J. Ngwa, Leonie Henschel, Andrea Kuehn, Nicole Pilch, Tim Weißbach, Alina N. Rosinski, Matthias Scheuermayer, Urska Repnik, Jude M. Przyborski, Allen M. Minns, Lindsey M. Orchard, Gareth Griffiths, Scott Eugene Lindner, Manuel Llinas, Gabriele Pradel, 2018, PLoS Pathogens

Specific Inhibition of the Bifunctional Farnesyl/Geranylgeranyl Diphosphate Synthase in Malaria Parasites via a New Small-Molecule Binding Site

Jolyn E. Gisselberg, Zachary Herrera, Lindsey M. Orchard, Manuel Llinas, Ellen Yeh, 2018, Cell Chemical Biology on p. 185-193.e5

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

Annie N. Cowell, Eva S. Istvan, Amanda K. Lukens, Maria G. Gomez-Lorenzo, Manu Vanaerschot, Tomoyo Sakata-Kato, Erika L. Flannery, Pamela Magistrado, Edward Owen, Matthew Abraham, Gregory La Monte, Heather Jill Painter Ponton, Roy M. Williams, Virginia Franco, Maria Linares, Ignacio Arriaga, Selina Bopp, Victoria C. Corey, Nina F. Gnädig, Olivia Coburn-Flynn, Christin Reimer, Purva Gupta, James M. Murithi, Pedro A. Moura, Olivia Fuchs, Erika Sasaki, Sang W. Kim, Christine H. Teng, Lawrence T. Wang, Asl Akidil, Sophie Adjalley, Paul A. Willis, Dionicio Siegel, Olga Tanaseichuk, Yang Zhong, Yingyao Zhou, Manuel Llinas, Sabine Ottilie, Francisco Javier Gamo, Marcus C.S. Lee, Daniel E. Goldberg, David A. Fidock, Dyann F. Wirth, Elizabeth A. Winzeler, 2018, Science on p. 191-199

Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum parasites

Nanika Coetzee, Simone Sidoli, Riëtte Van Biljon, Heather Jill Painter Ponton, Manuel Llinas, Benjamin A. Garcia, Lyn Marie Birkholtz, 2017, Scientific reports

Recent High-Impact Papers

New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq

Thomas D. Otto, Daniel Wilinski, Sammy Assefa, Thomas M. Keane, Louis R. Sarry, Ulrike Böhme, Jacob Lemieux, Bart Barrell, Arnab Pain, Matthew Berriman, Chris Newbold, Manuel Llinas, 2010, Molecular Microbiology on p. 12-24

Host-Parasite Interactions Revealed by Plasmodium falciparum Metabolomics

Kellen L. Olszewski, Joanne M. Morrisey, Daniel Wilinski, James M. Burns, Akhil B. Vaidya, Joshua D. Rabinowitz, Manuel Llinas, 2009, Cell Host and Microbe on p. 191-199

A transcriptional switch underlies commitment to sexual development in malaria parasites

Björn F.C. Kafsack, Núria Rovira-Graells, Taane G. Clark, Cristina Bancells, Valerie M. Crowley, Susana G. Campino, April E. Williams, Laura G. Drought, Dominic P. Kwiatkowski, David A. Baker, Alfred Cortés, Manuel Llinas, 2014, Nature on p. 248-252

A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium

Abhinav Sinha, Katie R. Hughes, Katarzyna K. Modrzynska, Thomas D. Otto, Claudia Pfander, Nicholas J. Dickens, Agnieszka A. Religa, Ellen Bushell, Anne L. Graham, Rachael Cameron, Bjorn F.C. Kafsack, April E. Williams, Manuel Llinas, Matthew Berriman, Oliver Billker, Andrew P. Waters, 2014, Nature on p. 253-257

Identification and Genome-Wide Prediction of DNA Binding Specificities for the ApiAP2 family of regulators from the malaria parasite

Tracey L. Campbell, Erandi K. de Silva, Kellen L. Olszewski, Olivier Elemento, Manuel Llinas, 2010, PLoS Pathogens

Branched tricarboxylic acid metabolism in Plasmodium falciparum

Kellen L. Olszewski, Michael W. Mather, Joanne M. Morrisey, Benjamin A. Garcia, Akhil B. Vaidya, Joshua D. Rabinowitz, Manuel Llinas, 2010, Nature on p. 774-778

Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network

Germán Plata, Tzu Lin Hsiao, Kellen L. Olszewski, Manuel Llinas, Dennis Vitkup, 2010, Molecular Systems Biology

Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases

Judith Straimer, Marcus C.S. Lee, Andrew H. Lee, Bryan Zeitler, April E. Williams, Jocelynn R. Pearl, Lei Zhang, Edward J. Rebar, Philip D. Gregory, Manuel Llinas, Fyodor D. Urnov, David A. Fidock, 2012, Nature methods on p. 993-998

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Wesley C. Van Voorhis, John H. Adams, Roberto Adelfio, Vida Ahyong, Myles H. Akabas, Pietro Alano, Aintzane Alday, Yesmalie Alemán Resto, Aishah Alsibaee, Ainhoa Alzualde, Katherine T. Andrews, Simon V. Avery, Vicky M. Avery, Lawrence Ayong, Mark Baker, Stephen Baker, Choukri Ben Mamoun, Sangeeta Bhatia, Quentin Bickle, Lotfi Bounaadja, Tana Bowling, Jürgen Bosch, Lauren E. Boucher, Fabrice F. Boyom, Jose Brea, Marian Brennan, Audrey Burton, Conor R. Caffrey, Grazia Camarda, Manuela Carrasquilla, Dee Carter, Maria Belen Cassera, Ken Chih-Chien Cheng, Worathad Chindaudomsate, Anthony Chubb, Beatrice L. Colon, Daisy D. Colón-López, Yolanda Corbett, Gregory J. Crowther, Noemi Cowan, Sarah D’Alessandro, Na Le Dang, Michael Delves, Joseph L. DeRisi, Alan Y. Du, Sandra Duffy, Shimaa Abd El-Salam El-Sayed, Michael T. Ferdig, José A. Fernández Robledo, David A. Fidock, Isabelle Florent, Patrick V.T. Fokou, Ani Galstian, Francisco Javier Gamo, Suzanne Gokool, Ben Gold, Todd Golub, Gregory M. Goldgof, Rajarshi Guha, W. Armand Guiguemde, Nil Gural, R. Kiplin Guy, Michael A.E. Hansen, Kirsten K. Hanson, Andrew Hemphill, Rob Hooft van Huijsduijnen, Takaaki Horii, Paul Horrocks, Tyler B. Hughes, Christopher Huston, Ikuo Igarashi, Katrin Ingram-Sieber, Maurice A. Itoe, Ajit Jadhav, Amornrat Naranuntarat Jensen, Laran T. Jensen, Rays H.Y. Jiang, Annette Kaiser, Jennifer Keiser, Thomas Ketas, Sebastien Kicka, Sunyoung Kim, Kiaran Kirk, Vidya P. Kumar, Dennis E. Kyle, Maria Jose Lafuente, Scott Landfear, Nathan Lee, Sukjun Lee, Adele M. Lehane, Fengwu Li, David Little, Liqiong Liu, Manuel Llinas, Maria I. Loza, Aristea Lubar, Leonardo Lucantoni, Isabelle Lucet, Louis Maes, Dalu Mancama, Nuha R. Mansour, Sandra March, Sheena McGowan, Iset Medina Vera, Stephan Meister, Luke Mercer, Jordi Mestres, Alvine N. Mfopa, Raj N. Misra, Seunghyun Moon, John P. Moore, Francielly Morais Rodrigues da Costa, Joachim Müller, Arantza Muriana, Stephen Nakazawa Hewitt, Bakela Nare, Carl Nathan, Nathalie Narraidoo, Sujeevi Nawaratna, Kayode K. Ojo, Diana Ortiz, Gordana Panic, George Papadatos, Silvia Parapini, Kailash Patra, Ngoc Pham, Sarah Prats, David M. Plouffe, Sally Ann Poulsen, Anupam Pradhan, Celia Quevedo, Ronald J. Quinn, Christopher A. Rice, Mohamed Abdo Rizk, Andrea Ruecker, Robert St. Onge, Rafaela Salgado Ferreira, Jasmeet Samra, Natalie G. Robinett, Ulrich Schlecht, Marjorie Schmitt, Filipe Silva Villela, Francesco Silvestrini, Robert Sinden, Dennis A. Smith, Thierry Soldati, Andreas Spitzmüller, Serge Maximilian Stamm, David J. Sullivan, William Sullivan, Sundari Suresh, Brian M. Suzuki, Yo Suzuki, S. Joshua Swamidass, Donatella Taramelli, Lauve R.Y. Tchokouaha, Anjo Theron, David Thomas, Kathryn F. Tonissen, Simon Townson, Abhai K. Tripathi, Valentin Trofimov, Kenneth O. Udenze, Imran Ullah, Cindy Vallieres, Edgar Vigil, Joseph M. Vinetz, Phat Voong Vinh, Hoan Vu, Nao Aki Watanabe, Kate Weatherby, Pamela M. White, Andrew F. Wilks, Elizabeth A. Winzeler, Edward Wojcik, Melanie Wree, Wesley Wu, Naoaki Yokoyama, Paul H.A. Zollo, Nada Abla, Benjamin Blasco, Jeremy Burrows, Benoît Laleu, Didier Leroy, Thomas Spangenberg, Timothy Wells, Paul A. Willis, 2016, PLoS Pathogens

A Plasmodium falciparum Histone Deacetylase regulates antigenic variation and gametocyte conversion

Bradley I. Coleman, Kristen M. Skillman, Rays H.Y. Jiang, Lauren M. Childs, Lindsey M. Altenhofen, Markus Ganter, Yvette Leung, Ilana Goldowitz, Björn F.C. Kafsack, Matthias Marti, Manuel Llinas, Caroline O. Buckee, Manoj T. Duraisingh, 2014, Cell Host and Microbe on p. 177-186