Manuel Llinas

Distinguished Professor of Biochemistry and Molecular Biology

Manuel Llinas

Research Summary

Understanding the molecular mechanisms of gene regulation and metabolism in the malaria parasite Plasmodium falciparum using functional genomics and metabolomics.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Parasites Malaria Plasmodium Falciparum Antimalarials Genes Plasmodium Genome Mutation Pharmaceutical Preparations Dna Binding Proteins Sexual Development Membranes Blood Sex Differentiation Drugs Culicidae Life Cycle Stages Metabolism In Vitro Techniques Antimalarial Gene Expression Glutathione Transferase Piperaquine Virulence Artesunate

Most Recent Publications

Laura E. de Vries, Patrick A.M. Jansen, Catalina Barcelo, Justin Munro, Julie M.J. Verhoef, Charisse Flerida A. Pasaje, Kelly Rubiano, Josefine Striepen, Nada Abla, Luuk Berning, Judith M. Bolscher, Claudia Demarta-Gatsi, Rob W.M. Henderson, Tonnie Huijs, Karin M.J. Koolen, Patrick K. Tumwebaze, Tomas Yeo, Anna C.C. Aguiar, Iñigo Angulo-Barturen, Alisje Churchyard, Jake Baum, Benigno Crespo Fernández, Aline Fuchs, Francisco Javier Gamo, Rafael V.C. Guido, María Belén Jiménez-Diaz, Dhelio B. Pereira, Rosemary Rochford, Camille Roesch, Laura M. Sanz, Graham Trevitt, Benoit Witkowski, Sergio Wittlin, Roland A. Cooper, Philip J. Rosenthal, Robert W. Sauerwein, Joost Schalkwijk, Pedro H.H. Hermkens, Roger V. Bonnert, Brice Campo, David A. Fidock, Manuel Llinás, Jacquin C. Niles, Taco W.A. Kooij, Koen J. Dechering, 2022, Nature Communications

The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages

Lauren B. Arendse, James M. Murithi, Tarrick Qahash, Charisse Flerida A. Pasaje, Luiz C. Godoy, Sumanta Dey, Liezl Gibhard, Sonja Ghidelli-Disse, Gerard Drewes, Marcus Bantscheff, Maria J. Lafuente-Monasterio, Stephen Fienberg, Lynn Wambua, Samuel Gachuhi, Dina Coertzen, Mariëtte van der Watt, Janette Reader, Ayesha S. Aswat, Erica Erlank, Nelius Venter, Nimisha Mittal, Madeline R. Luth, Sabine Ottilie, Elizabeth A. Winzeler, Lizette L. Koekemoer, Lyn Marie Birkholtz, Jacquin C. Niles, Manuel Llinás, David A. Fidock, Kelly Chibale, 2022, Science Translational Medicine

John Okombo, Sachel Mok, Tarrick Qahash, Tomas Yeo, Jade Bath, Lindsey M. Orchard, Edward Owens, Imhoi Koo, Istvan Albert, Manuel Llinás, David A. Fidock, 2022, PLoS Pathogens

Carolina M. Andrade, Hannah Fleckenstein, Richard Thomson-Luque, Safiatou Doumbo, Nathalia F. Lima, Carrie Anderson, Julia Hibbert, Christine S. Hopp, Tuan M. Tran, Shanping Li, Moussa Niangaly, Hamidou Cisse, Didier Doumtabe, Jeff Skinner, Dan Sturdevant, Stacy Ricklefs, Kimmo Virtaneva, Muhammad Asghar, Manijeh Vafa Homann, Louise Turner, Joana Martins, Erik L. Allman, Marie Esther N’Dri, Volker Winkler, Manuel Llinás, Catherine Lavazec, Craig Martens, Anna Färnert, Kassoum Kayentao, Aissata Ongoiba, Thomas Lavstsen, Nuno S. Osório, Thomas D. Otto, Mario Recker, Boubacar Traore, Peter D. Crompton, Silvia Portugal, 2022, Nature Medicine on p. 2216

Timothy James Russell, Erandi K. De Silva, Valerie M. Crowley, Kathryn Shaw-Saliba, Namita Dube, Gabrielle Josling, Charisse Flerida A. Pasaje, Irene Kouskoumvekaki, Gianni Panagiotou, Jacquin C. Niles, Marcelo Jacobs-Lorena, C. Denise Okafor, Francisco Javier Gamo, Manuel Llinás, 2022, PLoS Pathogens

Robert L. Summers, Charisse Flerida A. Pasaje, Joao P. Pisco, Josefine Striepen, Madeline R. Luth, Krittikorn Kumpornsin, Emma F. Carpenter, Justin T. Munro, De Lin, Andrew Plater, Avinash S. Punekar, Andrew M. Shepherd, Sharon M. Shepherd, Manu Vanaerschot, James M. Murithi, Kelly Rubiano, Aslı Akidil, Sabine Ottilie, Nimisha Mittal, A. Hazel Dilmore, Madalyn Won, Rebecca E.K. Mandt, Kerry McGowen, Edward Owen, Chris Walpole, Manuel Llinás, Marcus C.S. Lee, Elizabeth A. Winzeler, David A. Fidock, Ian H. Gilbert, Dyann F. Wirth, Jacquin C. Niles, Beatriz Baragaña, Amanda K. Lukens, 2022, Cell Chemical Biology on p. 191-201.e8

Riward A. Campelo Morillo, Xinran Tong, Wei Xie, Steven Abel, Lindsey M. Orchard, Wassim Daher, Dinshaw J. Patel, Manuel Llinás, Karine G. Le Roch, Björn F.C. Kafsack, 2022, Nature Microbiology on p. 289-299

Francois Eya’ane Meva, Timothy J. Prior, David J. Evans, Sachin Shah, Cynthia Fake Tamngwa, Herschelle Guyenne Lagrange Belengue, Roland Emmanuel Mang, Justin Munro, Tarrick Qahash, Manuel Llinás, 2022, Research on Chemical Intermediates on p. 885-898

Riward A. Campelo Morillo, Xinran Tong, Wei Xie, Steven Abel, Lindsey M. Orchard, Wassim Daher, Dinshaw J. Patel, Manuel Llinás, Karine G. Le Roch, Björn F.C. Kafsack, 2022, Nature Microbiology

H Painter, Neo Chung, Aswathy Sebastian, Istvan Albert, John Storey, Llin\'as, Manuel, Manuel Llinás, 2022, Nature Communications on p. 1--1

Most-Cited Papers

Björn F.C. Kafsack, Núria Rovira-Graells, Taane G. Clark, Cristina Bancells, Valerie M. Crowley, Susana G. Campino, April E. Williams, Laura G. Drought, Dominic P. Kwiatkowski, David A. Baker, Alfred Cortés, Manuel Llinás, 2014, Nature on p. 248-252

Abhinav Sinha, Katie R. Hughes, Katarzyna K. Modrzynska, Thomas D. Otto, Claudia Pfander, Nicholas J. Dickens, Agnieszka A. Religa, Ellen Bushell, Anne L. Graham, Rachael Cameron, Bjorn F.C. Kafsack, April E. Williams, Manuel Llinás, Matthew Berriman, Oliver Billker, Andrew P. Waters, 2014, Nature on p. 253-257

Wesley C. Van Voorhis, John H. Adams, Roberto Adelfio, Vida Ahyong, Myles H. Akabas, Pietro Alano, Aintzane Alday, Yesmalie Alemán Resto, Aishah Alsibaee, Ainhoa Alzualde, Katherine T. Andrews, Simon V. Avery, Vicky M. Avery, Lawrence Ayong, Mark Baker, Stephen Baker, Choukri Ben Mamoun, Sangeeta Bhatia, Quentin Bickle, Lotfi Bounaadja, Tana Bowling, Jürgen Bosch, Lauren E. Boucher, Fabrice F. Boyom, Jose Brea, Marian Brennan, Audrey Burton, Conor R. Caffrey, Grazia Camarda, Manuela Carrasquilla, Dee Carter, Maria Belen Cassera, Ken Chih-Chien Cheng, Worathad Chindaudomsate, Anthony Chubb, Beatrice L. Colon, Daisy D. Colón-López, Yolanda Corbett, Gregory J. Crowther, Noemi Cowan, Sarah D’Alessandro, Na Le Dang, Michael Delves, Joseph L. DeRisi, Alan Y. Du, Sandra Duffy, Shimaa Abd El-Salam El-Sayed, Michael T. Ferdig, José A. Fernández Robledo, David A. Fidock, Isabelle Florent, Patrick V.T. Fokou, Ani Galstian, Francisco Javier Gamo, Suzanne Gokool, Ben Gold, Todd Golub, Gregory M. Goldgof, Rajarshi Guha, W. Armand Guiguemde, Nil Gural, R. Kiplin Guy, Michael A.E. Hansen, Kirsten K. Hanson, Andrew Hemphill, Rob Hooft van Huijsduijnen, Takaaki Horii, Paul Horrocks, Tyler B. Hughes, Christopher Huston, Ikuo Igarashi, Katrin Ingram-Sieber, Maurice A. Itoe, Ajit Jadhav, Amornrat Naranuntarat Jensen, Laran T. Jensen, Rays H.Y. Jiang, Annette Kaiser, Jennifer Keiser, Thomas Ketas, Sebastien Kicka, Sunyoung Kim, Kiaran Kirk, Vidya P. Kumar, Dennis E. Kyle, Maria Jose Lafuente, Scott Landfear, Nathan Lee, Sukjun Lee, Adele M. Lehane, Fengwu Li, David Little, Liqiong Liu, Manuel Llinás, Maria I. Loza, Aristea Lubar, Leonardo Lucantoni, Isabelle Lucet, Louis Maes, Dalu Mancama, Nuha R. Mansour, Sandra March, Sheena McGowan, Iset Medina Vera, Stephan Meister, Luke Mercer, Jordi Mestres, Alvine N. Mfopa, Raj N. Misra, Seunghyun Moon, John P. Moore, Francielly Morais Rodrigues da Costa, Joachim Müller, Arantza Muriana, Stephen Nakazawa Hewitt, Bakela Nare, Carl Nathan, Nathalie Narraidoo, Sujeevi Nawaratna, Kayode K. Ojo, Diana Ortiz, Gordana Panic, George Papadatos, Silvia Parapini, Kailash Patra, Ngoc Pham, Sarah Prats, David M. Plouffe, Sally Ann Poulsen, Anupam Pradhan, Celia Quevedo, Ronald J. Quinn, Christopher A. Rice, Mohamed Abdo Rizk, Andrea Ruecker, Robert St. Onge, Rafaela Salgado Ferreira, Jasmeet Samra, Natalie G. Robinett, Ulrich Schlecht, Marjorie Schmitt, Filipe Silva Villela, Francesco Silvestrini, Robert Sinden, Dennis A. Smith, Thierry Soldati, Andreas Spitzmüller, Serge Maximilian Stamm, David J. Sullivan, William Sullivan, Sundari Suresh, Brian M. Suzuki, Yo Suzuki, S. Joshua Swamidass, Donatella Taramelli, Lauve R.Y. Tchokouaha, Anjo Theron, David Thomas, Kathryn F. Tonissen, Simon Townson, Abhai K. Tripathi, Valentin Trofimov, Kenneth O. Udenze, Imran Ullah, Cindy Vallieres, Edgar Vigil, Joseph M. Vinetz, Phat Voong Vinh, Hoan Vu, Nao Aki Watanabe, Kate Weatherby, Pamela M. White, Andrew F. Wilks, Elizabeth A. Winzeler, Edward Wojcik, Melanie Wree, Wesley Wu, Naoaki Yokoyama, Paul H.A. Zollo, Nada Abla, Benjamin Blasco, Jeremy Burrows, Benoît Laleu, Didier Leroy, Thomas Spangenberg, Timothy Wells, Paul A. Willis, 2016, PLoS Pathogens

Bradley I. Coleman, Kristen M. Skillman, Rays H.Y. Jiang, Lauren M. Childs, Lindsey M. Altenhofen, Markus Ganter, Yvette Leung, Ilana Goldowitz, Björn F.C. Kafsack, Matthias Marti, Manuel Llinás, Caroline O. Buckee, Manoj T. Duraisingh, 2014, Cell Host and Microbe on p. 177-186

Annie N. Cowell, Eva S. Istvan, Amanda K. Lukens, Maria G. Gomez-Lorenzo, Manu Vanaerschot, Tomoyo Sakata-Kato, Erika L. Flannery, Pamela Magistrado, Edward Owen, Matthew Abraham, Gregory La Monte, Heather J. Painter, Roy M. Williams, Virginia Franco, Maria Linares, Ignacio Arriaga, Selina Bopp, Victoria C. Corey, Nina F. Gnädig, Olivia Coburn-Flynn, Christin Reimer, Purva Gupta, James M. Murithi, Pedro A. Moura, Olivia Fuchs, Erika Sasaki, Sang W. Kim, Christine H. Teng, Lawrence T. Wang, Asl Akidil, Sophie Adjalley, Paul A. Willis, Dionicio Siegel, Olga Tanaseichuk, Yang Zhong, Yingyao Zhou, Manuel Llinás, Sabine Ottilie, Francisco Javier Gamo, Marcus C.S. Lee, Daniel E. Goldberg, David A. Fidock, Dyann F. Wirth, Elizabeth A. Winzeler, 2018, Science on p. 191-199

Sexual development in Plasmodium parasites: Knowing when it's time to commit

Gabrielle A. Josling, Manuel Llinás, 2015, Nature Reviews Microbiology on p. 573-587

Liliana Mancio-Silva, Ksenija Slavic, Margarida T. Grilo Ruivo, Ana Rita Grosso, Katarzyna K. Modrzynska, Iset Medina Vera, Joana Sales-Dias, Ana Rita Gomes, Cameron Ross Macpherson, Pierre Crozet, Mattia Adamo, Elena Baena-Gonzalez, Rita Tewari, Manuel Llinás, Oliver Billker, Maria M. Mota, 2017, Nature on p. 213-216

Erik L. Allman, Heather J. Painter, Jasmeet Samra, Manuela Carrasquilla, Manuel Llinás, 2016, Antimicrobial Agents and Chemotherapy on p. 6635-6643

Hangjun Ke, Ian A. Lewis, Joanne M. Morrisey, Kyle J. McLean, Suresh M. Ganesan, Heather J. Painter, Michael W. Mather, Marcelo Jacobs-Lorena, Manuel Llinás, Akhil B. Vaidya, 2015, Cell Reports on p. 164-174

Andreas Martin Lisewski, Joel P. Quiros, Caroline L. Ng, Anbu Karani Adikesavan, Kazutoyo Miura, Nagireddy Putluri, Richard T. Eastman, Daniel Scanfeld, Sam J. Regenbogen, Lindsey Altenhofen, Manuel Llinás, Arun Sreekumar, Carole Long, David A. Fidock, Olivier Lichtarge, 2014, Cell on p. 916-928

News Articles Featuring Manuel Llinas

Cancer drug could potentially be used against malaria

A cancer drug currently in clinical trials has shown the potential to protect from, cure, and prevent transmission of malaria. The breakthrough finding by an international team that includes researchers at Penn State offers new hope against a disease that kills over half a million people annually, most severely affecting children under five, pregnant women, and patients with HIV.

Penn State biochemist Manuel Llinás named distinguished professor

Manuel Llinás, professor of biochemistry and molecular biology and of chemistry at Penn State, has been selected to receive the title of distinguished professor of biochemistry and molecular biology in recognition of his exceptional record of teaching, research, and service to the University community.

Malaria parasites hide out in humans when it's not mosquito season

Malaria parasites survive the mosquito-free dry season by waiting silently in humans for the return of the rainy season that brings back with it mosquitoes. New research, by an international team including Penn State scientists, helps explain how the Plasmodium falciparum parasite survives the disruption to its lifecycle, which requires development within the mosquito host for transmission between people.

New tool in fight against malaria

Redesigning molecules originally developed to treat the skin disease psoriasis could lead to an effective new drug against malaria, according to an international team of researchers.