Donna Korzick

Chair, Intercollege Graduate Degree Program in Physiology; Professor of Physiology and Kinesiology

Donna Korzick

Research Summary

My research is focused on aging, post-menopausal women, and cardiac ischemia reperfusion injury using animal models. We are particularly interested in the effects of estrogen deficiency on mitochondrial regulation of cell survival following myocardial infarction.  Multiple levels of inquiry addressing mitochondrial quality control regulation and immune signaling is emphasized.

Graduate Students

Huck Institutes Affiliations

Links

Publication Tags

Proteins Estrogens Ethanol Alcohols Mitochondria Rats Alcohol Drinking Agar Proteomics Inbred F344 Rats Diet Respiration Mitochondrial Proteins Estrogen Receptor Beta Menopause Reperfusion Injury Therapeutics Ischemia Ovary Messenger Rna Nutrition Adiponectin Protein Kinases Vasoconstriction Calcium

Most Recent Papers

Age and ischemia differentially impact mitochondrial ultrastructure and function in a novel model of age-associated estrogen deficiency in the female rat heart

Alexandra M. Garvin, Nicole C. Aurigemma, Jenna L. Hackenberger, Donna H. Korzick, 2017, Pflugers Archiv European Journal of Physiology on p. 1591-1602

Evidence of Altered Mitochondrial Protein Expression After Chronic Ethanol Consumption in the Aged Estrogen-Deficient Female Rat Heart

Alexandra M. Garvin, Jennifer L. Miller-Lee, Daniel R. Sharda, Gregory M. Kanski, J. Craig Hunter, Donna H. Korzick, 2017, Alcoholism: Clinical and Experimental Research on p. 1288-1297

Acute adiponectin delivery is cardioprotective in the aged female rat heart

Nanette J. Tomicek, Craig J. Hunter, Alexandra M. Machikas, Veronica Lopez, Donna H. Korzick, 2015, Geriatrics and Gerontology International on p. 636-646

Chronic alcohol consumption disrupts myocardial protein balance and function in aged, but not adult, female F344 rats

Charles H. Lang, Donna H. Korzick, 2014, American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Divergent effects of aging and sex on vasoconstriction to endothelin in coronary arterioles

Amanda J. Leblanc, Bei Chen, Patrick J. Dougherty, Rafael A. Reyes, Robert D. Shipley, Donna H. Korzick, Judy M. Muller-Delp, 2013, Microcirculation on p. 365-376

Aging accentuates alcohol-induced decrease in protein synthesis in gastrocnemius

Donna H. Korzick, Daniel R. Sharda, Anne M. Pruznak, Charles H. Lang, 2013, American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Estrogen Receptor Beta Does Not Influence Ischemic Tolerance in the Aged Female Rat Heart

Nanette J. Tomicek, Jennifer L. Miller-Lee, J. Craig Hunter, Donna H. Korzick, 2013, Cardiovascular Therapeutics on p. 32-37

Quantitative proteomic analysis reveals novel mitochondrial targets of estrogen deficiency in the aged female rat heart

D. H. Korzick, T. S. Lancaster, S. J. Jefferson, J. Craig Hunter, Veronica Lopez, J. E. Van Eyk, E. G. Lakatta, 2012, Physiological Genomics on p. 957-969

Age-dependent reductions in mitochondrial respiration are exacerbated by calcium in the female rat heart

J. Craig Hunter, Alexandra M. MacHikas, Donna H. Korzick, 2012, Gender Medicine on p. 197-206

Comparison of the agar block and Lieber-DeCarli diets to study chronic alcohol consumption in an aging model of Fischer 344 female rats

Daniel R. Sharda, Jennifer L. Miller-Lee, Gregory M. Kanski, J. Craig Hunter, Charles H. Lang, Mary J. Kennett, Donna H. Korzick, 2012, Journal of Pharmacological and Toxicological Methods on p. 257-263

High-Impact Papers

Rapid estrogen receptor-α activation improves ischemic tolerance in aged female rats through a novel protein kinase Cε -dependent mechanism

Jennifer L. Novotny, Amy M. Simpson, Nanette J. Tomicek, Timothy S. Lancaster, Donna H. Korzick, 2009, Endocrinology on p. 889-896

Quantitative proteomic analysis reveals novel mitochondrial targets of estrogen deficiency in the aged female rat heart

D. H. Korzick, T. S. Lancaster, S. J. Jefferson, J. Craig Hunter, Veronica Lopez, J. E. Van Eyk, E. G. Lakatta, 2012, Physiological Genomics on p. 957-969

Local delivery of a PKCε-activating peptide limits ischemia reperfusion injury in the aged female rat heart

T. S. Lancaster, S. J. Jefferson, D. H. Korzick, 2011, American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Aging accentuates alcohol-induced decrease in protein synthesis in gastrocnemius

Donna H. Korzick, Daniel R. Sharda, Anne M. Pruznak, Charles H. Lang, 2013, American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Chronic alcohol consumption disrupts myocardial protein balance and function in aged, but not adult, female F344 rats

Charles H. Lang, Donna H. Korzick, 2014, American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Divergent effects of aging and sex on vasoconstriction to endothelin in coronary arterioles

Amanda J. Leblanc, Bei Chen, Patrick J. Dougherty, Rafael A. Reyes, Robert D. Shipley, Donna H. Korzick, Judy M. Muller-Delp, 2013, Microcirculation on p. 365-376

Increased estrogen receptor β in adipose tissue is associated with increased intracellular and reduced circulating adiponectin protein levels in aged female rats

Nanette J. Tomicek, Timothy S. Lancaster, Donna H. Korzick, 2011, Gender Medicine on p. 325-333

Estrogen Receptor Beta Does Not Influence Ischemic Tolerance in the Aged Female Rat Heart

Nanette J. Tomicek, Jennifer L. Miller-Lee, J. Craig Hunter, Donna H. Korzick, 2013, Cardiovascular Therapeutics on p. 32-37

Comparison of the agar block and Lieber-DeCarli diets to study chronic alcohol consumption in an aging model of Fischer 344 female rats

Daniel R. Sharda, Jennifer L. Miller-Lee, Gregory M. Kanski, J. Craig Hunter, Charles H. Lang, Mary J. Kennett, Donna H. Korzick, 2012, Journal of Pharmacological and Toxicological Methods on p. 257-263

Age-dependent reductions in mitochondrial respiration are exacerbated by calcium in the female rat heart

J. Craig Hunter, Alexandra M. MacHikas, Donna H. Korzick, 2012, Gender Medicine on p. 197-206