Parisa Kalantari
Assistant Professor of Immunology
-
112 Research Unit A
University Park, PA - puk103@psu.edu
- 814-865-7696
Research Summary
Host-parasite interactions using Schistosoma mansoni-induced liver inflammation in mouse models. Modulation of immune responses by the parasite as well as the role of inflammasomes in inducing schistosomiasis.
Huck Graduate Students
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- Center for Cellular Dynamics
- Center for Malaria Research
Links
Most Recent Publications
NLRP3 and AIM2 inflammasome-triggered Th17 cell response promotes severe immunopathology in schistosomiasis
Parisa Kalantari, Ilana Shecter, Yoelkys Morales, Emily Miller, Kaile Jump, Miguel Stadecker, Plos Pathogens
NLRP3 and AIM2 inflammasomes exacerbate the pathogenic Th17 cell response to eggs of the helminth Schistosoma mansoni
Madhusoodhanan Suresh Kumar Meena Kumari, Pengyu Liu, Megan S. Nitchman, Santoshi Chaudhary, Kaile Jump, Yoelkys Morales, Emily A. Miller, Ilana Shecter, Miguel J. Stadecker, Parisa Kalantari, 2025, PLoS Pathogens
The balance between gasdermin D and STING signaling shapes the severity of schistosome immunopathology
Parisa Kalantari, Ilana Shecter, Jacob Hopkins, Andrea Pilotta Gois, Yoelkys Morales, Bijan F. Harandi, Shruti Sharma, Miguel J. Stadecker, 2023, Proceedings of the National Academy of Sciences of the United States of America
STING-dependent type-1 interferon restrains schistosome immunopathology via down-regulation of the CD209a lectin receptor
Parisa Kalantari, 2020, The Journal of Immunology on p. 227.11
The c-type lectin Receptor-Driven, Th17 Cell-Mediated severe pathology in schistosomiasis: Not all immune responses to helminth parasites are Th2 dominated
Parisa Kalantari, Stephen C. Bunnell, Miguel J. Stadecker, 2019, Frontiers in Immunology
Interplay between Plasmodium falciparum haemozoin and l-arginine: Implication for nitric oxide production
Yolanda Corbett, Sarah D'Alessandro, Silvia Parapini, Diletta Scaccabarozzi, Parisa Kalantari, Stefania Zava, Flavio Giavarini, Donatella Caruso, Irma Colombo, Timothy J. Egan, Nicoletta Basilico, 2018, Malaria Journal
The emerging role of pattern recognition receptors in the pathogenesis of Malaria
Parisa Kalantari, 2018, Vaccines
CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology
Parisa Kalantari, Yoelkys Morales, Emily A. Miller, Luis D. Jaramillo, Holly E. Ponichtera, Marcel A. Wuethrich, Cheolho Cheong, Maria C. Seminario, Joanne M. Russo, Stephen C. Bunnell, Miguel J. Stadecker, 2018, Cell Reports on p. 1288-1300
MIR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN)
Parisa Kalantari, Omid F. Harandi, Sarika Agarwal, Florentina Rus, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald, Daniel R. Caffrey, Douglas T. Golenbock, 2017, Journal of Biological Chemistry on p. 5634-5644
Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome
Sivapriya Kailasan Vanaja, Vijay A.K. Rathinam, Maninjay K. Atianand, Parisa Kalantari, Brian Skehan, Katherine A. Fitzgerald, John M. Leong, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 7765-7770
Most-Cited Papers
MIR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN)
Parisa Kalantari, Omid F. Harandi, Sarika Agarwal, Florentina Rus, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald, Daniel R. Caffrey, Douglas T. Golenbock, 2017, Journal of Biological Chemistry on p. 5634-5644
The c-type lectin Receptor-Driven, Th17 Cell-Mediated severe pathology in schistosomiasis: Not all immune responses to helminth parasites are Th2 dominated
Parisa Kalantari, Stephen C. Bunnell, Miguel J. Stadecker, 2019, Frontiers in Immunology
The emerging role of pattern recognition receptors in the pathogenesis of Malaria
Parisa Kalantari, 2018, Vaccines
CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology
Parisa Kalantari, Yoelkys Morales, Emily A. Miller, Luis D. Jaramillo, Holly E. Ponichtera, Marcel A. Wuethrich, Cheolho Cheong, Maria C. Seminario, Joanne M. Russo, Stephen C. Bunnell, Miguel J. Stadecker, 2018, Cell Reports on p. 1288-1300
Interplay between Plasmodium falciparum haemozoin and l-arginine: Implication for nitric oxide production
Yolanda Corbett, Sarah D'Alessandro, Silvia Parapini, Diletta Scaccabarozzi, Parisa Kalantari, Stefania Zava, Flavio Giavarini, Donatella Caruso, Irma Colombo, Timothy J. Egan, Nicoletta Basilico, 2018, Malaria Journal
The balance between gasdermin D and STING signaling shapes the severity of schistosome immunopathology
Parisa Kalantari, Ilana Shecter, Jacob Hopkins, Andrea Pilotta Gois, Yoelkys Morales, Bijan F. Harandi, Shruti Sharma, Miguel J. Stadecker, 2023, Proceedings of the National Academy of Sciences of the United States of America
NLRP3 and AIM2 inflammasomes exacerbate the pathogenic Th17 cell response to eggs of the helminth Schistosoma mansoni
Madhusoodhanan Suresh Kumar Meena Kumari, Pengyu Liu, Megan S. Nitchman, Santoshi Chaudhary, Kaile Jump, Yoelkys Morales, Emily A. Miller, Ilana Shecter, Miguel J. Stadecker, Parisa Kalantari, 2025, PLoS Pathogens
STING-dependent type-1 interferon restrains schistosome immunopathology via down-regulation of the CD209a lectin receptor
Parisa Kalantari, 2020, The Journal of Immunology on p. 227.11
News Articles Featuring Parisa Kalantari
Apr 15, 2025
Immune system proteins involved in severe parasitic disease identified
New insights into the mechanisms that cause more severe cases of schistosomiasis — a disease caused by parasitic worms and second only to malaria in terms of potential harm — have been revealed by researchers at Penn State.
Full Article
Nov 21, 2023
College of Ag Sciences recognizes faculty, staff for research achievements
Penn State’s College of Agricultural Sciences lauded outstanding accomplishments in research during the 2023 Research Awards Ceremony, held Nov. 1 at the Hintz Family Alumni Center on the University Park campus.
Full Article
May 04, 2023
Newly discovered immune system mechanism suppresses parasitic infection
Type I interferon, a protein that is important for the body’s defense against viruses, plays a critical role in suppressing inflammation in mice infected with the schistosome parasite, Penn State immunology researchers have found.
Full Article