Donna Korzick

Director of Graduate Training Initiatives; Chair, Intercollege Graduate Degree Program in Integrative and Biomedical Physiology; Professor of Physiology and Kinesiology

Donna Korzick

Research Summary

My research is focused on aging, post-menopausal women, and cardiac ischemia reperfusion injury using animal models. We are particularly interested in the effects of estrogen deficiency on mitochondrial regulation of cell survival following myocardial infarction. Multiple levels of inquiry addressing mitochondrial quality control regulation and immune signaling is emphasized.

Huck Graduate Students

Huck Affiliations

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Publication Tags

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Estrogens Heart Proteins Mitochondria Estrogen Mitochondrial Proteins Rats Ethanol Alcohols Reperfusion Injury Protein Inbred F344 Rats Ischemia Reperfusion Therapeutics Proteomics Myocardial Infarction Quality Control Evans Blue Arterioles Alcohol Drinking Endothelins Alcoholic Cardiomyopathy Vasoconstriction Necrosis

Most Recent Publications

Phenotypic Characterization of Macrophage and Monocyte Populations in the NLRP3 KO DAHL/SS-Nlrp3<sup>em2Mcwi</sup> Rat Model

Cesar De Jeronimo Diaz, Jiajing Teng, Ryan A. Flynn, Matthew Lin, Junyao Yuan, Connie J. Rogers, Donna H. Korzick, 2022, FASEB Journal

Evans Blue Dye Interferes with Gating for Certain Fluorochrome-Conjugated Antibodies Using Flow Cytometry in the Ischemic Rat Heart

Jiajing Teng, Cesar De Jeronimo Diaz, Ryan A. Flynn, Matthew Lin, Connie J. Rogers, Donna H. Korzick, 2022, FASEB Journal

Inhibition of programmed necrosis limits infarct size through altered mitochondrial and immune responses in the aged female rat heart

Alexandra M. Garvin, Morgan A. Jackson, Donna H. Korzick, 2018, American Journal of Physiology on p. H1434-H1442

Age and ischemia differentially impact mitochondrial ultrastructure and function in a novel model of age-associated estrogen deficiency in the female rat heart

Alexandra M. Garvin, Nicole C. Aurigemma, Jenna L. Hackenberger, Donna H. Korzick, 2017, Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere on p. 1591-1602

Evidence of Altered Mitochondrial Protein Expression After Chronic Ethanol Consumption in the Aged Estrogen-Deficient Female Rat Heart

Alexandra M. Garvin, Jennifer L. Miller-Lee, Daniel R. Sharda, Gregory M. Kanski, J. Craig Hunter, Donna H. Korzick, 2017, Alcoholism: Clinical and Experimental Research on p. 1288-1297

Acute adiponectin delivery is cardioprotective in the aged female rat heart

Nanette J. Tomicek, Craig J. Hunter, Alexandra M. Machikas, Veronica Lopez, Donna H. Korzick, 2015, Geriatrics and Gerontology International on p. 636-646

Estrogen and the female heart

A. A. Knowlton, D. H. Korzick, 2014, Molecular and Cellular Endocrinology on p. 31-39

Chronic alcohol consumption disrupts myocardial protein balance and function in aged, but not adult, female F344 rats

Charles H. Lang, Donna H. Korzick, 2014, American Journal of Physiology on p. R23-R33

Divergent effects of aging and sex on vasoconstriction to endothelin in coronary arterioles

Amanda J. Leblanc, Bei Chen, Patrick J. Dougherty, Rafael A. Reyes, Robert D. Shipley, Donna H. Korzick, Judy M. Muller-Delp, 2013, Microcirculation on p. 365-376

Aging accentuates alcohol-induced decrease in protein synthesis in gastrocnemius

Donna H. Korzick, Daniel R. Sharda, Anne M. Pruznak, Charles H. Lang, 2013, American Journal of Physiology on p. R887-R898

Most-Cited Papers

Estrogen and the female heart

A. A. Knowlton, D. H. Korzick, 2014, Molecular and Cellular Endocrinology on p. 31-39

Aging accentuates alcohol-induced decrease in protein synthesis in gastrocnemius

Donna H. Korzick, Daniel R. Sharda, Anne M. Pruznak, Charles H. Lang, 2013, American Journal of Physiology on p. R887-R898

Chronic alcohol consumption disrupts myocardial protein balance and function in aged, but not adult, female F344 rats

Charles H. Lang, Donna H. Korzick, 2014, American Journal of Physiology on p. R23-R33

Age-related differences in cardiac ischemia-reperfusion injury: Effects of estrogen deficiency

Donna H. Korzick, Timothy S. Lancaster, 2013, Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere on p. 669-685

Divergent effects of aging and sex on vasoconstriction to endothelin in coronary arterioles

Amanda J. Leblanc, Bei Chen, Patrick J. Dougherty, Rafael A. Reyes, Robert D. Shipley, Donna H. Korzick, Judy M. Muller-Delp, 2013, Microcirculation on p. 365-376

Estrogen Receptor Beta Does Not Influence Ischemic Tolerance in the Aged Female Rat Heart

Nanette J. Tomicek, Jennifer L. Miller-Lee, J. Craig Hunter, Donna H. Korzick, 2013, Cardiovascular Therapeutics on p. 32-37

Inhibition of programmed necrosis limits infarct size through altered mitochondrial and immune responses in the aged female rat heart

Alexandra M. Garvin, Morgan A. Jackson, Donna H. Korzick, 2018, American Journal of Physiology on p. H1434-H1442

Age and ischemia differentially impact mitochondrial ultrastructure and function in a novel model of age-associated estrogen deficiency in the female rat heart

Alexandra M. Garvin, Nicole C. Aurigemma, Jenna L. Hackenberger, Donna H. Korzick, 2017, Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere on p. 1591-1602

Acute adiponectin delivery is cardioprotective in the aged female rat heart

Nanette J. Tomicek, Craig J. Hunter, Alexandra M. Machikas, Veronica Lopez, Donna H. Korzick, 2015, Geriatrics and Gerontology International on p. 636-646

Evidence of Altered Mitochondrial Protein Expression After Chronic Ethanol Consumption in the Aged Estrogen-Deficient Female Rat Heart

Alexandra M. Garvin, Jennifer L. Miller-Lee, Daniel R. Sharda, Gregory M. Kanski, J. Craig Hunter, Donna H. Korzick, 2017, Alcoholism: Clinical and Experimental Research on p. 1288-1297

News Articles Featuring Donna Korzick

Apr 24, 2023

Donna Korzick leads training grant initiatives to new highs

There are many things Penn State does to improve the research environment for graduate students, from investments in instrumentation to the availability of mental health resources to recruitment of quality seminar speakers.

Full Article

Jul 27, 2021

Business Bootcamp marks restart of in-person graduate training

After 17 months of pandemic-necessitated online instruction, something resembling normalcy returned to the Huck as grad students were exposed to new career opportunities by the July 18-22 Business of Science bootcamp.

Full Article

Jun 16, 2021

Improving heart health for older women

 Heart attacks are the leading cause of death among postmenopausal women. New funding from the National Institute on Aging will enable Penn State researchers to explore the links between tiny receptors in our immune systems called inflammasomes and how/when cells die. These links may enable researchers to develop new therapies to treat and prevent heart disease in older women.

Full Article

Apr 08, 2021

New position will support graduate and post-graduate training

Donna Korzick, professor of physiology and kinesiology, recently assumed a new role as director of graduate training initiatives in the Huck Institutes for the Life Sciences. In this role, Korzick is dedicating half of her time to support the application for and execution of training grants from organizations like the National Institutes of Health.

Full Article

Mar 08, 2021

New Appointments to Build on Excellence in Graduate Training

Two familiar faces within the Huck's graduate program system will be adding new roles to support the Institutes' portfolio of extramurally-funded programs.

Full Article