Watching memories form with single neuron resolution

February 13, 2025 @ 11:00 am to 12:00 pm

William Frost, Rosalind Franklin University

110 Henderson Building
University Park

Abstract:
Studies of the mechanisms underlying memory formation have largely focused on the synapse. However, recent evidence suggests that additional, non-synaptic, mechanisms also play important roles in this process. Using voltage sensitive dye imaging with single neuron resolution, we recently described a novel memory mechanism whereby a particular class of neurons was recruited into the Tritonia escape swim network with sensitization, a non-associative form of learning. Neurons that in the naıve state were loosely-affiliated with the network were rapidly recruited in, transitioning from variably bursting (VB) to reliably bursting (RB). Even after the behavioral memory had faded some new neurons remained, and some original members had left, leaving the network in an altered state. Further, we identified a candidate cellular mechanism underlying these network changes. Our study supports the view that brain networks may have surprisingly fluid functional structures and adds to the growing body of evidence that nonsynaptic mechanisms often operate synergistically with changes at the synapse to mediate memory formation.

About the Speaker

  • BA. Reed College, 1978
  • PhD. with Eric Kandel, Columbia University, 1987
  • Post Doc with Peter Getting, Univ of Iowa 1987-1989
  • Assistant, Assoc. Professor. University of Texas Medical at Houston 1989-1998
  • In 1998-present. The Chicago Medical School, Rosalind Franklin University of Medicine and Science
  • Currently Professor and Chair, Cell Biology and Anatomy
  • Director, Stanson Toshok Center for Brain Function and Repair

Contact

Jeffrey Brown
jwbrown@psu.edu