Aug 04, 2021
Researchers film human viruses in liquid droplets at near-atomic detail
A research team led by Deb Kelly, Huck Chair in Molecular Biophysics and professor of biomedical engineering at Penn State, has used advanced electron microscopy (EM) technology to see how human viruses move in high resolution in a near-native environment. The visualization technique could lead to improved understanding of how vaccine candidates and treatments behave and function as they interact with target cells, Kelly said.
Jul 30, 2021
Novel method of imaging silicon anode degradation may lead to better batteries
A novel method of characterizing the structural and chemical evolution of silicon and a thin layer that governs battery stability may help resolve issues that prevent using silicon for high-capacity batteries, according to a group of researchers.
Jun 03, 2021
New images of canine parvovirus may help predict how virus jumps to new species
Canine parvovirus (CPV) is a highly infectious pathogen that causes severe diseases in unvaccinated dogs, including inflammation of the heart and acute gastrointestinal illness. Originating in cats, the virus is a rare example of a DNA-based virus that can jump between species, and a team of researchers’ discovery may help in predicting this and the virus’ ability to evolve, which could have implications for current vaccines used in dogs.
Apr 09, 2021
Antibody binding-site conserved across COVID-19 virus variants
A tiny protein of SARS-CoV-2, the coronavirus that gives rise to COVID-19, may have big implications for future treatments, according to a team of Penn State researchers.
Jan 25, 2021
Regulating the ribosomal RNA production line
Cryo-electron microscopy study allows researchers to visualize structural changes in an E. coli enzyme synthesizing ribosomal RNA that shift it between turbo- and slow-modes depending on the bacteria’s growth rate
Nov 23, 2020
Altered 'coat' disguises fatal brain virus from neutralizing antibodies
A genetic modification in the ‘coat’ of a brain infection-causing virus may allow it to escape antibodies, according to Penn State College of Medicine researchers.
Jul 27, 2020
Podcast features three women at the forefront of cryo-EM research
An all-female trio of Penn State research scientists explain how their work on cancer diagnostics and advanced materials science evolves along with improvements in cryo-electron microscopy.
Feb 07, 2020
Scientists solve structure enabling cyanobacteria to thrive in low light
Scientists have determined the structure of the protein complex that gives cyanobacteria their unique ability to convert weak, filtered sunlight into useable energy. Their findings could one day be used to engineer crops that thrive under low-light conditions.
Sep 24, 2019
Virus may jump species through 'rock-and-roll' motion with receptors
Like a janitor thumbing through a keychain to find just the right key to open a lock, the "rock-and-roll" motion of the canine parvovirus during the binding process may help explain how the virus can find the spot on a receptor to infect not just dogs, but multiple species, according to an international team of researchers.
Aug 19, 2019
Resolution Revolution: Penn State welcomes a new era of atomic-level imaging with cryo EM facility
Using extreme cold to arrest fluid samples in motion, cryo EM allows researchers to see proteins, clusters of molecules, and viruses with astounding clarity—to the point where individual atoms may become visible.