Eukaryotic Gene Regulation News | Eukaryotic Gene Regulation

Apr 26, 2024

Penn State molecular biologist Ross Hardison named an AAAS Fellow

Ross Hardison, Academy Professor and professor emeritus of biochemistry and molecular biology, has been named a fellow of the American Association for the Advancement of Science (AAAS).

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Jun 05, 2020

New image of a cancer-related enzyme in action helps explain gene regulation

New images of an enzyme in action as it interacts with the chromosome could provide important insight into how cells — including cancer cells — regulate their genes.

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“The Ccr4-Not complex is involved in nearly every step of this process from start to finish," said Reese. "Our new research shows that this complex has an additional function that helps maintain normal cellular function when something goes wrong during transcription.” During the transcription of RNA from DNA, RNAPII — itself a large complex made up of multiple protein subunits — travels along the strand of DNA reading the ATCG sequence and producing a complementary strand of RNA. If the RNAPII encounters DNA damage, which can be caused by UV radiation and other sources, it can become stuck and prevent

Apr 10, 2019

Unjamming the genome after DNA damage

A protein complex that is involved in nearly every step in the regulatory control of gene expression in cells has now been shown also to play a key role in clearing potential traffic jams in the production of RNA.

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Apr 08, 2015

Five Penn State professors honored with Faculty Scholar Medals

Huck-cofunded faculty researcher Song Tan is among the awardees.

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Nov 02, 2014

First detailed picture of a cancer-related cell enzyme in action on a chromosome

A landmark study by Huck faculty researcher Song Tan provides new insight into the function of an enzyme related to the BRCA1 breast cancer protein.

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May 12, 2014

Evan Pugh Professorships awarded to three Huck Institutes faculty

Nina Jablonski, B. Franklin Pugh, and Andrew Read have been named Evan Pugh Professors, the highest distinction bestowed by the University on its faculty.

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Sep 26, 2013

Scientists discover the origins of genomic "dark matter"

A duo of Penn State scientists that includes Huck Institutes affiliate B. Franklin Pugh has achieved a major milestone in understanding how genomic "dark matter" originates.

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Aug 06, 2013

Short-term gene-expression "memory" is inherited in proteins associated with DNA

By studying a gene in yeast, a team of scientists led by Huck Institutes affiliate Lu Bai has found that modifications to proteins associated with DNA can control whether or not a gene is allowed to function and may be important in maintaining a gene's "expression potential" so that future cells will behave as the parent cell did.

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Jul 29, 2013

Huck Institutes seek new Associate Directors for positions in science leadership

The Huck Institutes wish to appoint a series of new Associate Directors to work with the management team and help in developing new initiatives.

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May 06, 2013

Gene offers clues to new treatments for a harmful blood clotting disorder

A research team led by Huck Institutes affiliate Yanming Wang and Harvard's Denisa Wagner finds a gene that could offer new insights into treatment strategies for the harmful blood clots of deep-vein thrombosis.

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