Weihua Guan
Assistant Professor of Electrical Engineering
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111F Electrical Engineering West
University Park, PA - wzg111@psu.edu
- 814-867-5748
Most Recent Publications
Addressing Buffer, Size, and Clogging Challenges in LAMP-Coupled Solid-State Nanopores for Point-of-Care Testing
Ming Dong, Aneesh Kshirsagar, Anthony J. Politza, Muhammad Asad Ullah Khalid, Md Ahasan Ahamed, Weihua Guan, 2025, Analytical Chemistry on p. 7879-7887
Compact multiplex PCR device for HIV-1 and HIV-2 viral load determination from finger-prick whole blood in resource-limited settings
Tianyi Liu, Anthony J. Politza, Md Ahasan Ahamed, Aneesh Kshirsagar, Yusheng Zhu, Weihua Guan, 2025, Biosensors and Bioelectronics
CRISPR-based strategies for sample-to-answer monkeypox detection: current status and emerging opportunities
Md Ahasan Ahamed, Anthony J. Politza, Tianyi Liu, Muhammad Asad Ullah Khalid, Huanshu Zhang, Weihua Guan, 2025, Nanotechnology
Hydrogel interfaced glass nanopore for high-resolution sizing of short DNA fragments
Muhammad Asad Ullah Khalid, Md Ahasan Ahamed, Ming Dong, Aneesh Kshirsagar, Weihua Guan, 2025, Biosensors and Bioelectronics
Deep Learning Enabled Universal Multiplexed Fluorescence Detection for Point-of-Care Applications
Aneesh Kshirsagar, Anthony J. Politza, Weihua Guan, 2024, ACS Sensors on p. 4017-4027
Sample-to-answer salivary miRNA testing: New frontiers in point-of-care diagnostic technologies
Zhikun Zhang, Tianyi Liu, Ming Dong, Md Ahasan Ahamed, Weihua Guan, 2024, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Editorial for ‘focus collection in memory of Prof Mark A Reed’
Laurie Calvet, Weihua Guan, James Klemic, Takhee Lee, Mohsen Nami, Jeffrey Sleight, Eric Stern, Shari Yosinski, Chongwu Zhou, 2024, Nanotechnology
High Fidelity Machine-Learning-Assisted False Positive Discrimination in Loop-Mediated Isothermal Amplification Using Nanopore-Based Sizing and Counting
Ming Dong, Aneesh Kshirsagar, Anthony J. Politza, Weihua Guan, 2024, ACS Nano on p. 7170-7179
Sensitive and specific CRISPR-Cas12a assisted nanopore with RPA for Monkeypox detection
Md Ahasan Ahamed, Muhammad Asad Ullah Khalid, Ming Dong, Anthony J. Politza, Zhikun Zhang, Aneesh Kshirsagar, Tianyi Liu, Weihua Guan, 2024, Biosensors and Bioelectronics
CRISPR-assisted solid-state nanopore sensor for rapid and sensitive point-of-care amendable of monkeypox virus detection via RPA amplification
Md Ahamed, Weihua Guan, 2024, Biophysical Journal on p. 145a
Most-Cited Papers
CRISPR-based detection of SARS-CoV-2: A review from sample to result
Reza Nouri, Zifan Tang, Ming Dong, Tianyi Liu, Aneesh Kshirsagar, Weihua Guan, 2021, Biosensors and Bioelectronics
Sequence-Specific Recognition of HIV-1 DNA with Solid-State CRISPR-Cas12a-Assisted Nanopores (SCAN)
Reza Nouri, Yuqian Jiang, Xiaojun Lance Lian, Weihua Guan, 2020, ACS Sensors on p. 1273-1280
Direct Observation of Charge Inversion in Divalent Nanofluidic Devices
Sylvia Xin Li, Weihua Guan, Benjamin Weiner, Mark A. Reed, 2015, Nano Letters on p. 5046-5051
Noise in nanopore sensors: Sources, models, reduction, and benchmarking
Shengfa Liang, Feibin Xiang, Zifan Tang, Reza Nouri, Xiaodong He, Ming Dong, Weihua Guan, 2020, Nanotechnology and Precision Engineering on p. 9-17
Sample-to-answer palm-sized nucleic acid testing device towards low-cost malaria mass screening
Gihoon Choi, Theodore Prince, Jun Miao, Liwang Cui, Weihua Guan, 2018, Biosensors and Bioelectronics on p. 83-90
Detection of SARS-CoV-2 with Solid-State CRISPR-Cas12a-Assisted Nanopores
Reza Nouri, Yuqian Jiang, Zifan Tang, Xiaojun Lance Lian, Weihua Guan, 2021, Nano Letters on p. 8393-8400
A field-deployable mobile molecular diagnostic system for malaria at the point of need
Gihoon Choi, Daniel Song, Sony Shrestha, Jun Miao, Liwang Cui, Weihua Guan, 2016, Lab on a Chip - Miniaturisation for Chemistry and Biology on p. 4341-4349
Loop-Mediated Isothermal Amplification-Coupled Glass Nanopore Counting Toward Sensitive and Specific Nucleic Acid Testing
Zifan Tang, Gihoon Choi, Reza Nouri, Weihua Guan, 2019, Nano Letters on p. 7927-7934
Fingerpick Blood-Based Nucleic Acid Testing on A USB Interfaced Device towards HIV self-testing
Tianyi Liu, Gihoon Choi, Zifan Tang, Aneesh Kshirsagar, Anthony Politza, Weihua Guan, 2022, Biosensors and Bioelectronics on p. 114255
SLIDE: Saliva-Based SARS-CoV-2 Self-Testing with RT-LAMP in a Mobile Device
Zifan Tang, Jiarui Cui, Aneesh Kshirsagar, Tianyi Liu, Michele Yon, Suresh V. Kuchipudi, Weihua Guan, 2022, ACS Sensors on p. 2370--2378
News Articles Featuring Weihua Guan
Jun 20, 2023
Penn State researchers develop digital test to directly measure HIV viral load
A milliliter of blood contains about 15 individual drops. For a person with human immunodeficiency virus (HIV), each drop of blood could contain anywhere from fewer than 20 copies of the virus to more than 500,000 copies.
Full Article
Aug 05, 2022
New at-home, saliva-based COVID test as effective as PCR in preliminary analysis
PCR tests, also called molecular tests or nucleic acid tests, are considered the gold standard in detecting the presence of SARS-CoV-2, the virus that gives rise to COVID-19. However, they can take a few days to process, resulting in unnecessary quarantine for negative individuals or delays for those who require proof of negative testing for travel or other commitments.
Full Article
Apr 01, 2020
Penn State engineer developing device that may be able to test for COVID-19
A point-of-care testing device that may help diagnose the novel coronavirus disease (COVID-19) is under development by Weihua Guan, assistant professor of electrical engineering in Penn State’s College of Engineering.
Full Article
Mar 23, 2020
Penn State funds first round of COVID-19 research proposals
One week after launching a rapid-fire call for proposals, awards are granted to six projects that address the global pandemic, with more to follow
Full Article