Timothy Jegla

Emphasis Area Representative, Molecular and Evolutionary Genetics; Associate Professor of Biology

Timothy Jegla

Research Summary

Functional evolution of eukaryotic ion channels and evolution of neuronal signaling and cell structure.

Graduate Students

Huck Affiliations

Links

Publication Tags

Cnidaria Genes Voltage Gated Potassium Channels Neurons Potassium Channels Ether Ancestry Ctenophora Ankyrins Niacinamide Phenotype Phosphatidylinositols Drosophila Mutation Axons Cations Genome Action Potentials Glutamate Receptors Elks Ethers Nicotinamide S 6 Vertebrate Family

Most Recent Papers

Glutamate receptors

Mark L. Mayer, Timothy Jegla, 2018, eLife

The S6 gate in regulatory Kv6 subunits restricts heteromeric K<sup>+</sup> channel stoichiometry

Aditya Pisupati, Keith J. Mickolajczyk, William Horton, Damian B. van Rossum, Andriy Anishkin, Sree V. Chintapalli, Xiaofan Li, Jose Chu-Luo, Gregory Busey, William O. Hancock, Timothy Jegla, 2018, Journal of General Physiology on p. 1702-1721

Evolution and Structural Characteristics of Plant Voltage-Gated K+ Channels

Timothy Jegla, Gregory Busey, Sarah Assmann, 2018, The Plant Cell on p. 2898--2909

Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment

Timothy J. Jegla, Michelle M. Nguyen, Chengye Feng, Daniel J. Goetschius, Esteban Luna, Damian B. Van Rossum, Bishoy Kamel, Aditya Pisupati, Elliott S. Milner, Melissa Rolls, 2016, PLoS genetics

Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel

Awani Upadhyay, Aditya Pisupati, Timothy Jegla, Matt Crook, Keith J. Mickolajczyk, Matthew Shorey, Laura E. Rohan, Katherine A. Billings, Melissa M. Rolls, William O. Hancock, Wendy Hanna-Rose, 2016, Nature communications

Functional characterization of Cnidarian HCN channels points to an early evolution of Ih

Emma C. Baker, Michael J. Layden, Damian B. Van Rossum, Bishoy Kamel, Monica Medina, Eboni Simpson, Timothy J. Jegla, 2015, PLoS One on p. e0142730

Bimodal regulation of an Elk subfamily K<sup>+</sup> channel by phosphatidylinositol 4,5-bisphosphate

Xiaofan Li, Andriy Anishkin, Hansi Liu, Damian B. van Rossum, Sree V. Chintapalli, Jessica K. Sassic, David Gallegos, Kendra Pivaroff-Ward, Timothy Jegla, 2015, Journal of General Physiology on p. 357-374

Major diversification of voltage-gated K<sup>+</sup> channels occurred in ancestral parahoxozoans

Xiaofan Li, Hansi Liu, Jose Chu Luo, Sarah A. Rhodes, Liana M. Trigg, Damian B. Van Rossum, Andriy Anishkin, Fortunay H. Diatta, Jessica K. Sassic, David K. Simmons, Bishoy Kamel, Monica Medina, Mark Q. Martindale, Timothy Jegla, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. E1010-E1019

Ether-à-go-go family voltage-gated K<sup>+</sup> channels evolved in an ancestral metazoan and functionally diversified in a cnidarian-bilaterian ancestor

Xiaofan Li, Alexandra S. Martinson, Michael J. Layden, Fortunay H. Diatta, Anna P. Sberna, David K. Simmons, Mark Q. Martindale, Timothy J. Jegla, 2015, Journal of Experimental Biology on p. 526-536

Functional evolution of Erg potassium channel gating reveals an ancient origin for IKr

Alexandra S. Martinson, Damian B. Van Rossum, Fortunay H. Diatta, Michael J. Layden, Sarah A. Rhodes, Mark Q. Martindale, Timothy Jegla, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 5712-5717

Most-Cited Papers

Spiroindolones, a potent compound class for the treatment of malaria

Matthias Rottmann, Case McNamara, Bryan K.S. Yeung, Marcus C.S. Lee, Bin Zou, Bruce Russell, Patrick Seitz, David M. Plouffe, Neekesh V. Dharia, Jocelyn Tan, Steven B. Cohen, Kathryn R. Spencer, Gonzalo E. González-Páez, Suresh B. Lakshminarayana, Anne Goh, Rossarin Suwanarusk, Timothy J. Jegla, Esther K. Schmitt, Hans Peter Beck, Reto Brun, Francois Nosten, Laurent Renia, Veronique Dartois, Thomas H. Keller, David A. Fidock, Elizabeth A. Winzeler, Thierry T. Diagana, 2010, Science on p. 1175-1180

Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy

Xiaofei Zhang, Federica Bertaso, Jong W. Yoo, Karsten Baumgärtel, Sinead M. Clancy, Van Lee, Cynthia Cienfuegos, Carly Wilmot, Jacqueline Avis, Truc Hunyh, Catherine Daguia, Christian Schmedt, Jeffrey Noebels, Timothy J. Jegla, 2010, Nature Neuroscience on p. 1056-1058

Functional evolution of Erg potassium channel gating reveals an ancient origin for IKr

Alexandra S. Martinson, Damian B. Van Rossum, Fortunay H. Diatta, Michael J. Layden, Sarah A. Rhodes, Mark Q. Martindale, Timothy Jegla, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 5712-5717

Expanded Functional Diversity of Shaker K<sup>+</sup> Channels in Cnidarians Is Driven by Gene Expansion

Timothy Jegla, Heather Q. Marlow, Bihan Chen, David K. Simmons, Sarah M. Jacobo, Mark Q. Martindale, 2012, PloS one

Ether-à-go-go family voltage-gated K<sup>+</sup> channels evolved in an ancestral metazoan and functionally diversified in a cnidarian-bilaterian ancestor

Xiaofan Li, Alexandra S. Martinson, Michael J. Layden, Fortunay H. Diatta, Anna P. Sberna, David K. Simmons, Mark Q. Martindale, Timothy J. Jegla, 2015, Journal of Experimental Biology on p. 526-536

Bimodal regulation of an Elk subfamily K<sup>+</sup> channel by phosphatidylinositol 4,5-bisphosphate

Xiaofan Li, Andriy Anishkin, Hansi Liu, Damian B. van Rossum, Sree V. Chintapalli, Jessica K. Sassic, David Gallegos, Kendra Pivaroff-Ward, Timothy Jegla, 2015, Journal of General Physiology on p. 357-374

External pH modulates EAG superfamily K<sup>+</sup> channels through EAG-specific acidic residues in the voltage sensor

Marcin Kazmierczak, Xiaofei Zhang, Bihan Chen, Daniel K. Mulkey, Yingtang Shi, Paul G. Wagner, Kendra Pivaroff-Ward, Jessica K. Sassic, Douglas A. Bayliss, Timothy Jegla, 2013, Journal of General Physiology on p. 721-735

Major diversification of voltage-gated K<sup>+</sup> channels occurred in ancestral parahoxozoans

Xiaofan Li, Hansi Liu, Jose Chu Luo, Sarah A. Rhodes, Liana M. Trigg, Damian B. Van Rossum, Andriy Anishkin, Fortunay H. Diatta, Jessica K. Sassic, David K. Simmons, Bishoy Kamel, Monica Medina, Mark Q. Martindale, Timothy Jegla, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. E1010-E1019

Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment

Timothy J. Jegla, Michelle M. Nguyen, Chengye Feng, Daniel J. Goetschius, Esteban Luna, Damian B. Van Rossum, Bishoy Kamel, Aditya Pisupati, Elliott S. Milner, Melissa Rolls, 2016, PLoS genetics

Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel

Awani Upadhyay, Aditya Pisupati, Timothy Jegla, Matt Crook, Keith J. Mickolajczyk, Matthew Shorey, Laura E. Rohan, Katherine A. Billings, Melissa M. Rolls, William O. Hancock, Wendy Hanna-Rose, 2016, Nature communications