Timothy Jegla
Emphasis Area Representative, Molecular and Evolutionary Genetics; Associate Professor of Biology

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230 Huck Life Sciences
University Park, - tjj3@psu.edu
- 814-865-1668
Research Summary
Functional evolution of eukaryotic ion channels and evolution of neuronal signaling and cell structure.
Huck Graduate Students
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- Neuroscience
- Neuroscience Institute
- Center for Molecular Investigation of Neurological Disorders
- Center for Brain, Behavior, and Cognition
- Center for Cellular Dynamics
Links
Publication Tags
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Neurons Cnidaria Genes Voltage Gated Potassium Channels Axons Phosphatidylinositols Ether Potassium Channels Niacinamide Ankyrins Ancestry Cyclic Nucleotides Cations Anthozoa Electric Potential Difference Ctenophora Drosophila Vertebrate Nervous System Prednisolone Axon Initial Segment Animals Hyperpolarization Activated Cyclic Nucleotide Gated Channels Vertebrates DendritesMost Recent Publications
External cd<sup>2+</sup> and protons activate the hyperpolarization-gated k<sup>+</sup> channelkat1atthe voltage sensor
Y Zhou, Sarah Assmann, Timothy Jegla, 2021, Journal of General Physiology
Cytoskeletal and synaptic polarity of LWamide-like+ ganglion neurons in the sea anemone Nematostella vectensis
Michelle C. Stone, Gregory O. Kothe, Melissa M. Rolls, Timothy Jegla, 2020, Journal of Experimental Biology
What is the correct stoichiometry of Kv2.1:Kv6.4 heteromers?
Aditya Pisupati, Keith Mickolajczyk, William Hancock, Timothy Jegla, 2020, Proceedings of the National Academy of Sciences of the United States of America on p. 29288-29289
The S6 gate in regulatory Kv6 subunits restricts heteromeric K<sup>+</sup> channel stoichiometry
Aditya Pisupati, Keith Mickolajczyk, William Horton, D van Rossum, A Anishkin, Sree Chintapalli, Xiaofan Li, Jose Chu-Luo, Gregory Busey, W Hancock, T Jegla, 2018, Journal of General Physiology on p. 1702-1721
Glutamate receptors: Family matters
Mark L. Mayer, Timothy Jegla, 2018, eLife on p. e43815
Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment
Timothy Jegla, Michelle M. Nguyen, Chengye Feng, Daniel J. Goetschius, Esteban Luna, Damian B. van Rossum, Bishoy Kamel, Aditya Pisupati, Elliott S. Milner, Melissa M. Rolls, 2016, PLoS Genetics
Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel
Awani Upadhyay, Aditya Pisupati, Timothy Jegla, Matt Crook, Keith J. Mickolajczyk, Matthew Shorey, Laura E. Rohan, Katherine A. Billings, Melissa M. Rolls, William O. Hancock, Wendy Hanna-Rose, 2016, Nature Communications
Guard cell sensory systems: recent insights on stomatal responses to light, abscisic acid, and CO<sub>2</sub>
Sarah M. Assmann, Timothy Jegla, 2016, Current Opinion in Plant Biology on p. 157-167
Functional characterization of Cnidarian HCN channels points to an early evolution of Ih
Emma C. Baker, Michael J. Layden, Damian B. Van Rossum, Bishoy Kamel, Monica Medina, Eboni Simpson, Timothy Jegla, 2015, PLoS One on p. e0142730
Bimodal regulation of an Elk subfamily K<sup>+</sup> channel by phosphatidylinositol 4,5-bisphosphate
Xiaofan Li, Andriy Anishkin, Hansi Liu, Damian B. van Rossum, Sree V. Chintapalli, Jessica K. Sassic, David Gallegos, Kendra Pivaroff-Ward, Timothy Jegla, 2015, Journal of General Physiology on p. 357-374
Most-Cited Papers
Guard cell sensory systems: recent insights on stomatal responses to light, abscisic acid, and CO<sub>2</sub>
Sarah M. Assmann, Timothy Jegla, 2016, Current Opinion in Plant Biology on p. 157-167
Neuronal polarity: An evolutionary perspective
Melissa M. Rolls, Timothy J. Jegla, 2015, Journal of Experimental Biology on p. 572-580
Functional evolution of Erg potassium channel gating reveals an ancient origin for IKr
Alexandra S. Martinson, Damian B. Van Rossum, Fortunay H. Diatta, Michael J. Layden, Sarah A. Rhodes, Mark Q. Martindale, Timothy Jegla, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 5712-5717
External pH modulates EAG superfamily K<sup>+</sup> channels through EAG-specific acidic residues in the voltage sensor
Marcin Kazmierczak, Xiaofei Zhang, Bihan Chen, Daniel K. Mulkey, Yingtang Shi, Paul G. Wagner, Kendra Pivaroff-Ward, Jessica K. Sassic, Douglas A. Bayliss, Timothy Jegla, 2013, Journal of General Physiology on p. 721-735
Ether-à-go-go family voltage-gated K<sup>+</sup> channels evolved in an ancestral metazoan and functionally diversified in a cnidarian-bilaterian ancestor
Xiaofan Li, Alexandra S. Martinson, Michael J. Layden, Fortunay H. Diatta, Anna P. Sberna, David K. Simmons, Mark Q. Martindale, Timothy J. Jegla, 2015, Journal of Experimental Biology on p. 526-536
Major diversification of voltage-gated K<sup>+</sup> channels occurred in ancestral parahoxozoans
Xiaofan Li, Hansi Liu, Jose Chu Luo, Sarah A. Rhodes, Liana M. Trigg, Damian B. Van Rossum, Andriy Anishkin, Fortunay H. Diatta, Jessica K. Sassic, David K. Simmons, Bishoy Kamel, Monica Medina, Mark Q. Martindale, Timothy Jegla, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. E1010-E1019
Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel
Awani Upadhyay, Aditya Pisupati, Timothy Jegla, Matt Crook, Keith J. Mickolajczyk, Matthew Shorey, Laura E. Rohan, Katherine A. Billings, Melissa M. Rolls, William O. Hancock, Wendy Hanna-Rose, 2016, Nature Communications
Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment
Timothy Jegla, Michelle M. Nguyen, Chengye Feng, Daniel J. Goetschius, Esteban Luna, Damian B. van Rossum, Bishoy Kamel, Aditya Pisupati, Elliott S. Milner, Melissa M. Rolls, 2016, PLoS Genetics
Bimodal regulation of an Elk subfamily K<sup>+</sup> channel by phosphatidylinositol 4,5-bisphosphate
Xiaofan Li, Andriy Anishkin, Hansi Liu, Damian B. van Rossum, Sree V. Chintapalli, Jessica K. Sassic, David Gallegos, Kendra Pivaroff-Ward, Timothy Jegla, 2015, Journal of General Physiology on p. 357-374
Functional characterization of Cnidarian HCN channels points to an early evolution of Ih
Emma C. Baker, Michael J. Layden, Damian B. Van Rossum, Bishoy Kamel, Monica Medina, Eboni Simpson, Timothy Jegla, 2015, PLoS One on p. e0142730