Timothy Jegla

Emphasis Area Representative, Molecular and Evolutionary Genetics; Associate Professor of Biology

Timothy Jegla

Research Summary

Functional evolution of eukaryotic ion channels and evolution of neuronal signaling and cell structure.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Neurons Cnidaria Genes Voltage Gated Potassium Channels Potassium Channels Axons Electric Potential Difference Niacinamide Ankyrins Ancestry Ether Cyclic Nucleotides Animals Ctenophora Nervous System Drosophila Vertebrate Anthozoa Phenotype Vertebrates Axon Initial Segment Cations Dendrites Ion Channels Optical Character Recognition

Most Recent Papers

External Cd2+ and protons activate the hyperpolarization-gated K+ channel KAT1 at the voltage sensor

Yunqing Zhou, Sarah M. Assmann, Timothy Jegla, 2021, Journal of General Physiology

What is the correct stoichiometry of Kv2.1:Kv6.4 heteromers?

Aditya Pisupati, Keith J. Mickolajczyk, William O. Hancock, Timothy Jegla, 2020, Proceedings of the National Academy of Sciences of the United States of America on p. 29288-29289

Cytoskeletal and synaptic polarity of LWamide-like+ ganglion neurons in the sea anemone Nematostella vectensis

Michelle C. Stone, Gregory O. Kothe, Melissa M. Rolls, Timothy Jegla, 2020, Journal of Experimental Biology

The S6 gate in regulatory Kv6 subunits restricts heteromeric K<sup>+</sup> channel stoichiometry

Aditya Pisupati, Keith J. Mickolajczyk, William Horton, Damian B. van Rossum, Andriy Anishkin, Sree V. Chintapalli, Xiaofan Li, Jose Chu-Luo, Gregory Busey, William O. Hancock, Timothy Jegla, 2018, Journal of General Physiology on p. 1702-1721

Evolution and structural characteristics of plant voltage-gated K <sup>+</sup> channels

Timothy Jegla, Gregory Busey, Sarah M. Assmann, 2018, Plant Cell on p. 2898-2909

Glutamate Receptors: Family matters

Mark Mayer, Timothy Jegla, 2018, eLife on p. e43815

Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment

Timothy J. Jegla, Michelle M. Nguyen, Chengye Feng, Daniel J. Goetschius, Esteban Luna, Damian B. Van Rossum, Bishoy Kamel, Aditya Pisupati, Elliott S. Milner, Melissa Rolls, 2016, PLoS Genetics

Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel

Awani Upadhyay, Aditya Pisupati, Timothy Jegla, Matt Crook, Keith J. Mickolajczyk, Matthew Shorey, Laura E. Rohan, Katherine A. Billings, Melissa M. Rolls, William O. Hancock, Wendy Hanna-Rose, 2016, Nature Communications

Guard cell sensory systems

Sarah M. Assmann, Timothy Jegla, 2016, Current Opinion in Plant Biology on p. 157-167

Functional characterization of Cnidarian HCN channels points to an early evolution of Ih

Emma C. Baker, Michael J. Layden, Damian B. Van Rossum, Bishoy Kamel, Monica Medina, Eboni Simpson, Timothy J. Jegla, 2015, PLoS One on p. e0142730

Most-Cited Papers

Guard cell sensory systems

Sarah M. Assmann, Timothy Jegla, 2016, Current Opinion in Plant Biology on p. 157-167

Neuronal polarity

Melissa M. Rolls, Timothy J. Jegla, 2015, Journal of Experimental Biology on p. 572-580

Functional evolution of Erg potassium channel gating reveals an ancient origin for IKr

Alexandra S. Martinson, Damian B. Van Rossum, Fortunay H. Diatta, Michael J. Layden, Sarah A. Rhodes, Mark Q. Martindale, Timothy Jegla, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 5712-5717

Expanded Functional Diversity of Shaker K<sup>+</sup> Channels in Cnidarians Is Driven by Gene Expansion

Timothy Jegla, Heather Q. Marlow, Bihan Chen, David K. Simmons, Sarah M. Jacobo, Mark Q. Martindale, 2012, PLoS One

External pH modulates EAG superfamily K<sup>+</sup> channels through EAG-specific acidic residues in the voltage sensor

Marcin Kazmierczak, Xiaofei Zhang, Bihan Chen, Daniel K. Mulkey, Yingtang Shi, Paul G. Wagner, Kendra Pivaroff-Ward, Jessica K. Sassic, Douglas A. Bayliss, Timothy Jegla, 2013, Journal of General Physiology on p. 721-735

Ether-à-go-go family voltage-gated K<sup>+</sup> channels evolved in an ancestral metazoan and functionally diversified in a cnidarian-bilaterian ancestor

Xiaofan Li, Alexandra S. Martinson, Michael J. Layden, Fortunay H. Diatta, Anna P. Sberna, David K. Simmons, Mark Q. Martindale, Timothy J. Jegla, 2015, Journal of Experimental Biology on p. 526-536

Major diversification of voltage-gated K<sup>+</sup> channels occurred in ancestral parahoxozoans

Xiaofan Li, Hansi Liu, Jose Chu Luo, Sarah A. Rhodes, Liana M. Trigg, Damian B. Van Rossum, Andriy Anishkin, Fortunay H. Diatta, Jessica K. Sassic, David K. Simmons, Bishoy Kamel, Monica Medina, Mark Q. Martindale, Timothy Jegla, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. E1010-E1019

Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment

Timothy J. Jegla, Michelle M. Nguyen, Chengye Feng, Daniel J. Goetschius, Esteban Luna, Damian B. Van Rossum, Bishoy Kamel, Aditya Pisupati, Elliott S. Milner, Melissa Rolls, 2016, PLoS Genetics

Evolution and structural characteristics of plant voltage-gated K <sup>+</sup> channels

Timothy Jegla, Gregory Busey, Sarah M. Assmann, 2018, Plant Cell on p. 2898-2909

Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel

Awani Upadhyay, Aditya Pisupati, Timothy Jegla, Matt Crook, Keith J. Mickolajczyk, Matthew Shorey, Laura E. Rohan, Katherine A. Billings, Melissa M. Rolls, William O. Hancock, Wendy Hanna-Rose, 2016, Nature Communications