Timothy Jegla

Emphasis Area Representative, Molecular and Evolutionary Genetics; Associate Professor of Biology

Timothy Jegla

Research Summary

Functional evolution of eukaryotic ion channels and evolution of neuronal signaling and cell structure.

Huck Graduate Students

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Publication Tags

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Neurons Voltage Gated Potassium Channels Cnidaria Potassium Channels Axons Ether Genes Animals Electric Potential Difference Ctenophora Ancestry Nervous System Dendrites Phenotype Ankyrins Niacinamide Glutamate Receptors Plant Characteristics Cyclic Nucleotides Protons Vertebrate Drosophila Genome Vertebrates Metazoan

Most Recent Publications

Kv12-encoded K<sup>+</sup> channels drive the day–night switch in the repetitive firing rates of SCN neurons

Tracey O. Hermanstyne, Nien Du Yang, Daniel Granados-Fuentes, Xiaofan Li, Rebecca L. Mellor, Timothy Jegla, Erik D. Herzog, Jeanne M. Nerbonne, 2023, Journal of General Physiology

Genome-Scale Analysis Reveals Extensive Diversification of Voltage-Gated K+ Channels in Stem Cnidarians

Adolfo Lara, Benjamin T. Simonson, Joseph F. Ryan, Timothy Jegla, 2023, Genome Biology and Evolution

Kv12-Encoded K (+) Channels Drive the Day-Night Switch in the Repetitive Firing Rates of SCN Neurons.

T Hermanstyne, N Yang, D Granados-Fuentes, X Li, R Mellor, Timothy Jegla, E Herzog, J Nerbonne, 2023, bioRxiv : the preprint server for biology

Taxonomy and Evolution of Ion Channels

Timothy Jegla, Benjamin T. Simonson, 2023, on p. 1-14

External cd<sup>2+</sup> and protons activate the hyperpolarization-gated k<sup>+</sup> channelkat1atthe voltage sensor

Y Zhou, Sarah Assmann, Timothy Jegla, 2021, Journal of General Physiology

Cytoskeletal and synaptic polarity of LWamide-like+ ganglion neurons in the sea anemone Nematostella vectensis

Michelle C. Stone, Gregory O. Kothe, Melissa M. Rolls, Timothy Jegla, 2020, Journal of Experimental Biology

What is the correct stoichiometry of Kv2.1:Kv6.4 heteromers?

Aditya Pisupati, Keith Mickolajczyk, William Hancock, Timothy Jegla, 2020, Proceedings of the National Academy of Sciences of the United States of America on p. 29288-29289

The S6 gate in regulatory Kv6 subunits restricts heteromeric K<sup>+</sup> channel stoichiometry

Aditya Pisupati, Keith Mickolajczyk, William Horton, D van Rossum, A Anishkin, Sree Chintapalli, Xiaofan Li, Jose Chu-Luo, Gregory Busey, W Hancock, T Jegla, 2018, Journal of General Physiology on p. 1702-1721

Evolution and structural characteristics of plant voltage-gated K<sup>+</sup> channels

Timothy Jegla, Gregory Busey, Sarah Assmann, 2018, Plant Cell on p. 2898-2909

Glutamate receptors: Family matters

Mark L. Mayer, Timothy Jegla, 2018, eLife on p. e43815

Most-Cited Papers

Guard cell sensory systems: recent insights on stomatal responses to light, abscisic acid, and CO<sub>2</sub>

Sarah M. Assmann, Timothy Jegla, 2016, Current Opinion in Plant Biology on p. 157-167

Evolution and structural characteristics of plant voltage-gated K<sup>+</sup> channels

Timothy Jegla, Gregory Busey, Sarah Assmann, 2018, Plant Cell on p. 2898-2909

Neuronal polarity: An evolutionary perspective

Melissa M. Rolls, Timothy J. Jegla, 2015, Journal of Experimental Biology on p. 572-580

Functional evolution of Erg potassium channel gating reveals an ancient origin for IKr

Alexandra S. Martinson, Damian B. Van Rossum, Fortunay H. Diatta, Michael J. Layden, Sarah A. Rhodes, Mark Q. Martindale, Timothy Jegla, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 5712-5717

External pH modulates EAG superfamily K<sup>+</sup> channels through EAG-specific acidic residues in the voltage sensor

Marcin Kazmierczak, Xiaofei Zhang, Bihan Chen, Daniel K. Mulkey, Yingtang Shi, Paul G. Wagner, Kendra Pivaroff-Ward, Jessica K. Sassic, Douglas A. Bayliss, Timothy Jegla, 2013, Journal of General Physiology on p. 721-735

Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment

Timothy Jegla, Michelle M. Nguyen, Chengye Feng, Daniel J. Goetschius, Esteban Luna, Damian B. van Rossum, Bishoy Kamel, Aditya Pisupati, Elliott S. Milner, Melissa M. Rolls, 2016, PLoS Genetics

Major diversification of voltage-gated K<sup>+</sup> channels occurred in ancestral parahoxozoans

Xiaofan Li, Hansi Liu, Jose Chu Luo, Sarah A. Rhodes, Liana M. Trigg, Damian B. Van Rossum, Andriy Anishkin, Fortunay H. Diatta, Jessica K. Sassic, David K. Simmons, Bishoy Kamel, Monica Medina, Mark Q. Martindale, Timothy Jegla, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. E1010-E1019

Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel

Awani Upadhyay, Aditya Pisupati, Timothy Jegla, Matt Crook, Keith J. Mickolajczyk, Matthew Shorey, Laura E. Rohan, Katherine A. Billings, Melissa M. Rolls, William O. Hancock, Wendy Hanna-Rose, 2016, Nature Communications

Ether-à-go-go family voltage-gated K<sup>+</sup> channels evolved in an ancestral metazoan and functionally diversified in a cnidarian-bilaterian ancestor

Xiaofan Li, Alexandra S. Martinson, Michael J. Layden, Fortunay H. Diatta, Anna P. Sberna, David K. Simmons, Mark Q. Martindale, Timothy J. Jegla, 2015, Journal of Experimental Biology on p. 526-536

Bimodal regulation of an Elk subfamily K<sup>+</sup> channel by phosphatidylinositol 4,5-bisphosphate

Xiaofan Li, Andriy Anishkin, Hansi Liu, Damian B. van Rossum, Sree V. Chintapalli, Jessica K. Sassic, David Gallegos, Kendra Pivaroff-Ward, Timothy Jegla, 2015, Journal of General Physiology on p. 357-374