Thomas Ma
Professor and Chair of Medicine
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500 University Drive
Hershey, PA - tum606@psu.edu
Huck Affiliations
Publication Tags
Tight Junctions Permeability Caco 2 Cells Intestinal Mucosa Myosin Light Chain Kinase Occludin Lipopolysaccharides Intestines Epithelial Cells Inbred C57bl Mouse Ethanol Transcriptional Activation Toll Like Receptor 4 Up Regulation Transfection Messenger Rna Map Kinase Signaling System Crohn Disease Small Interfering Rna Enterocytes Mice Interleukin 1beta Tumor Necrosis Factor Alpha Cell Membrane Permeability Protein TransportMost Recent Papers
The gut microbiome and alcoholic liver disease
Erick S. Lebrun, Meghali Nighot, Viszwapriya Dharmaprakash, Anand Kumar, Chien Chi Lo, Patrick S.G. Chain, Thomas Y. Ma, 2021, Life on p. 1-11
IL1B Increases Intestinal Tight Junction Permeability by Up-regulation of MIR200C-3p, Which Degrades Occludin mRNA
Manmeet Rawat, Meghali Nighot, Rana Al-Sadi, Yash Gupta, Dharmaprakash Viszwapriya, Gregory Yochum, Walter Koltun, Thomas Y. Ma, 2020, Gastroenterology on p. 1375-1389
Investigating intestinal permeability and gut microbiota roles in acute coronary syndrome patients
T. Alhmoud, A. Kumar, Chien Chi Lo, Rana Al-Sadi, Stacey Clegg, Ihab Alomari, T. Zmeili, Cheryl Diane Gleasne, Kim Mcmurry, Armand Earl Ko Dichosa, Momchiloo Vuyisich, Patrick Sam Guy Chain, Shiraz Mishra, Thomas Ma, 2019, Human Microbiome Journal
Intestinal epithelial tight junction barrier regulation by autophagy-related protein ATG6/beclin 1
Morgan Wong, Ashwinkumar Subramenium Ganapathy, Eric Suchanec, Laura Laidler, Thomas Ma, Prashant Nighot, 2019, American Journal of Physiology on p. C753-C765
Lipopolysaccharide-induced increase in intestinal permeability is mediated by TAK-1 activation of IKK and MLCK/MYLK gene
Meghali Nighot, Manmeet Rawat, Rana Al-Sadi, Eliseo F. Castillo, Prashant Nighot, Thomas Ma, 2019, American Journal of Pathology on p. 797-812
MMP-9-induced increase in intestinal epithelial tight permeability is mediated by p38 kinase signaling pathway activation of MLCK gene
Rana Al-Sadi, Moustafa Youssef, Manmeet Rawat, Shuhong Guo, Karol Dokladny, Mohammad Haque, Martin D. Watterson, Thomas Y. Ma, 2019, American Journal of Physiology on p. G278-G290
Expression of programmed death-ligand 1 by human colonic CD90<sup>+</sup> stromal cells differs between ulcerative colitis and Crohn's disease and determines their capacity to suppress Th1 cells
Ellen J. Beswick, Carl Grim, Abinav Singh, Jose E. Aguirre, Marissa Tafoya, Suimin Qiu, Gerhard Rogler, Rohini McKee, Von Samedi, Thomas Y. Ma, Victor E. Reyes, Don W. Powell, Irina V. Pinchuk, 2018, Frontiers in Immunology
Lipopolysaccharide-Induced Increase in Intestinal Epithelial Tight Permeability Is Mediated by Toll-Like Receptor 4/Myeloid Differentiation Primary Response 88 (MyD88) Activation of Myosin Light Chain Kinase Expression
Meghali Nighot, Rana Al-Sadi, Shuhong Guo, Manmeet Rawat, Prashant Nighot, Martin D. Watterson, Thomas Ma, 2017, American Journal of Pathology on p. 2698-2710
Chloride channel ClC- 2 enhances intestinal epithelial tight junction barrier function via regulation of caveolin-1 and caveolar trafficking of occludin
Prashant K. Nighot, Lana Leung, Thomas Y. Ma, 2017, Experimental Cell Research on p. 113-122
Intestinal barrier dysfunction in human necrotizing enterocolitis
Sarah A. Moore, Prashant Nighot, Cynthia Reyes, Manmeet Rawat, Jason McKee, David Lemon, Joshua Hanson, Thomas Y. Ma, 2016, Journal of Pediatric Surgery on p. 1907-1913
Most-Cited Papers
Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14
Shuhong Guo, Rana Al-Sadi, Hamid M. Said, Thomas Ma, 2013, American Journal of Pathology on p. 375-387
Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier
Rana Al-Sadi, Khaldun Khatib, Shuhong Guo, Dongmei Ye, Moustafa Youssef, Thomas Ma, 2011, American Journal of Physiology on p. G1054-G1064
MicroRNA regulation of intestinal epithelial tight junction permeability
Dongmei Ye, Shuhong Guo, Rana Al-Sadi, Thomas Ma, 2011, Gastroenterology on p. 1323-1333
Lipopolysaccharide regulation of intestinal tight junction permeability is mediated by TLR4 signal transduction pathway activation of FAK and MyD88
Shuhong Guo, Meghali Nighot, Rana Al-Sadi, Tarik Alhmoud, Prashant Nighot, Thomas Ma, 2015, Journal of Immunology on p. 4999-5010
TNF-α modulation of intestinal epithelial tight junction barrier is regulated by ERK1/2 activation of Elk-1
Rana Al-Sadi, Shuhong Guo, Dongmei Ye, Thomas Y. Ma, 2013, American Journal of Pathology on p. 1871-1884
Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway
Rana Al-Sadi, Dongmei Ye, Michel Boivin, Shuhong Guo, Mariam Hashimi, Lisa Ereifej, Thomas Y. Ma, 2014, PLoS One
Autophagy enhances intestinal epithelial tight junction barrier function by targeting claudin-2 protein degradation
Prashant K. Nighot, Chien An Andy Hu, Thomas Y. Ma, 2015, Journal of Biological Chemistry on p. 7234-7246
TNF-α Modulation of Intestinal Tight Junction Permeability Is Mediated by NIK/IKK-α Axis Activation of the Canonical NF-κB Pathway
Rana Al-Sadi, Shuhong Guo, Dongmei Ye, Manmeet Rawat, Thomas Y. Ma, 2016, American Journal of Pathology on p. 1151-1165
Mechanism of IL-1β modulation of intestinal epithelial barrier involves p38 kinase and activating transcription factor-2 activation
Rana Al-Sadi, Shuhong Guo, Dongmei Ye, Karol Dokladny, Tarik Alhmoud, Lisa Ereifej, Hamid M. Said, Thomas Ma, 2013, Journal of Immunology on p. 6596-6606
Mechanism of Interleukin-1β induced-increase in mouse intestinal permeability in vivo
Rana Al-Sadi, Shuhong Guo, Karol Dokladny, Matthew A. Smith, Dongmei Ye, Archana Kaza, D. Martin Watterson, Thomas Ma, 2012, Journal of Interferon and Cytokine Research on p. 474-484