Thomas Ma
Professor and Chair of Medicine
-
500 University Drive
Hershey, PA - tum606@psu.edu
Huck Affiliations
Publication Tags
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Tight Junctions Permeability Caco 2 Cells Intestinal Mucosa Inflammation Myosin Light Chain Kinase Signal Transduction Toll Like Receptor 4 Inbred C57bl Mouse Interleukin 1 Matrix Metalloproteinase 9 Lipopolysaccharides Tight Junction Proteins Phosphotransferases Transcriptional Activation Membranes Epithelial Cells Chemical Activation Colitis Map Kinase Signaling System Tumor Necrosis Factor Alpha In Vitro Techniques Dextran Sulfate Genetic Promoter Regions Inflammatory Bowel DiseasesMost Recent Publications
Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways
A Ganapathy, K Saha, A Wang, P Arumugam, V Dharmaprakash, Gregory Yochum, Walter Koltun, M Nighot, Gary H. Perdew, T Thompson, Thomas Ma, Prashant Nighot, 2023, Cell Reports on p. 112705
Editorial: Role of matrix metalloproteinases and other inflammatory mediators in the disruption of the intestinal tight junction barrier
Rana Al-Sadi, Raz Abdulqadir, Thomas Ma, 2023, Frontiers in Immunology
Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation
Kushal Saha, Ashwinkumar Subramenium Ganapathy, Alexandra Wang, Priya Arumugam, Nathan Michael Morris, Leonard Harris, Gregory Yochum, Walter Koltun, Gary H. Perdew, Meghali Nighot, Thomas Ma, Prashant Nighot, 2023, Mucosal Immunology
NASHFit: A randomized controlled trial of an exercise training program to reduce clotting risk in patients with NASH
Jonathan G. Stine, Ian R. Schreibman, Alison J. Faust, Jessica Dahmus, Benjamin Stern, Christopher Soriano, Gloriany Rivas, Breianna Hummer, Scot R. Kimball, Nate R. Geyer, Vernon M. Chinchilli, Rohit Loomba, Kathryn Schmitz, Christopher Sciamanna, Cindy Strine, Rachel Wentzel, Sara Marlin, Chris Sica, Jeff Vesek, Elaine Eyster, Lawrence Sinoway, Kathy Bentz, Nancy Handley, Brenda Hershey Fell, Shirlynn Mottilla, Christine Christ, Susan George, Terry Novchich, Megan Beyer, Kofi Clarke, Tiffany Myers, Martha Glading-Steinruck, Karen Krok, Thomas Ma, Thomas Riley, Elizabeth Thompson, Heather Tressler, James Broach, Trang Doan, Sue Patrick, Syndi Reed, Chris Hamilton, Kristin Slavoski, Deborah Tregea, 2022, Hepatology on p. 172-185
IL-1β and the Intestinal Epithelial Tight Junction Barrier
Lauren W. Kaminsky, Rana Al-Sadi, Thomas Y. Ma, 2021, Frontiers in Immunology
Matrix Metalloproteinase MMP-12 Promotes Macrophage Transmigration across Intestinal Epithelial Tight Junctions and Increases Severity of Experimental Colitis
Meghali Nighot, Ashwinkumar Subramenium Ganapathy, Kushal Saha, Eric Suchanec, Eliseo F. Castillo, Alyssa Gregory, Steven Shapiro, Thomas Ma, Prashant Nighot, 2021, Journal of Crohn's and Colitis on p. 1751-1765
Bifidobacterium bifidum enhances the intestinal epithelial tight junction barrier and protects against intestinal inflammation by targeting the toll-like receptor-2 pathway in an nf-κb-independent manner
Rana Al-Sadi, V Dharmaprakash, Prashant Nighot, S Guo, Meghali Nighot, T Do, Thomas Ma, 2021, International Journal of Molecular Sciences
Lactobacillus acidophilus Induces a Strain-specific and Toll-Like Receptor 2–Dependent Enhancement of Intestinal Epithelial Tight Junction Barrier and Protection Against Intestinal Inflammation
Rana Al-Sadi, Prashant Nighot, Meghali Nighot, Mohammad Haque, Manmeet Rawat, Thomas Y. Ma, 2021, American Journal of Pathology on p. 872-884
Matrix Metalloproteinase-9 (MMP-9) induced disruption of intestinal epithelial tight junction barrier is mediated by NF-κB activation
Rana Al-Sadi, Jessica Engers, Mohammad Haque, Steven King, Deemah Al-Omari, Thomas Y. Ma, 2021, PLoS One
Endocytosis of Intestinal Tight Junction Proteins: In Time and Space
Prashant Nighot, Thomas Ma, 2021, Inflammatory Bowel Diseases on p. 283-290
Most-Cited Papers
Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14
Shuhong Guo, Rana Al-Sadi, Hamid M. Said, Thomas Ma, 2013, American Journal of Pathology on p. 375-387
Lipopolysaccharide regulation of intestinal tight junction permeability is mediated by TLR4 signal transduction pathway activation of FAK and MyD88
Shuhong Guo, Meghali Nighot, Rana Al-Sadi, Tarik Alhmoud, Prashant Nighot, Thomas Ma, 2015, Journal of Immunology on p. 4999-5010
Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway
Rana Al-Sadi, Dongmei Ye, Michel Boivin, Shuhong Guo, Mariam Hashimi, Lisa Ereifej, Thomas Y. Ma, 2014, PLoS One
TNF-α modulation of intestinal epithelial tight junction barrier is regulated by ERK1/2 activation of Elk-1
Rana Al-Sadi, Shuhong Guo, Dongmei Ye, Thomas Y. Ma, 2013, American Journal of Pathology on p. 1871-1884
Autophagy enhances intestinal epithelial tight junction barrier function by targeting claudin-2 protein degradation
Prashant K. Nighot, Chien An Andy Hu, Thomas Y. Ma, 2015, Journal of Biological Chemistry on p. 7234-7246
TNF-α Modulation of Intestinal Tight Junction Permeability Is Mediated by NIK/IKK-α Axis Activation of the Canonical NF-κB Pathway
Rana Al-Sadi, Shuhong Guo, Dongmei Ye, Manmeet Rawat, Thomas Y. Ma, 2016, American Journal of Pathology on p. 1151-1165
Lipopolysaccharide-Induced Increase in Intestinal Epithelial Tight Permeability Is Mediated by Toll-Like Receptor 4/Myeloid Differentiation Primary Response 88 (MyD88) Activation of Myosin Light Chain Kinase Expression
Meghali Nighot, Rana Al-Sadi, Shuhong Guo, Manmeet Rawat, Prashant Nighot, Martin D. Watterson, Thomas Y. Ma, 2017, American Journal of Pathology on p. 2698-2710
IL-1β and the Intestinal Epithelial Tight Junction Barrier
Lauren W. Kaminsky, Rana Al-Sadi, Thomas Y. Ma, 2021, Frontiers in Immunology
Mechanism of IL-1β modulation of intestinal epithelial barrier involves p38 kinase and activating transcription factor-2 activation
Rana Al-Sadi, Shuhong Guo, Dongmei Ye, Karol Dokladny, Tarik Alhmoud, Lisa Ereifej, Hamid M. Said, Thomas Ma, 2013, Journal of Immunology on p. 6596-6606
Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis
Prashant Nighot, Rana Al-Sadi, Manmeet Rawat, Shuhong Guo, D. Martin Watterson, Thomas Ma, 2015, American Journal of Physiology on p. G988-G997