Thomas Ma

Professor and Chair of Medicine

Thomas Ma

Huck Affiliations

Publication Tags

Tight Junctions Permeability Caco 2 Cells Intestinal Mucosa Myosin Light Chain Kinase Lipopolysaccharides Occludin Epithelial Cells Cell Membrane Permeability Protein Transport Tumor Necrosis Factor Alpha Toll Like Receptor 4 Intestines Transfection Map Kinase Signaling System Genes Inbred C57bl Mouse Interleukin 6 Small Interfering Rna Cytokines Inflammation Inflammatory Bowel Diseases In Vitro Techniques Proteins Membrane Proteins

Most Recent Papers

Endocytosis of Intestinal Tight Junction Proteins: In Time and Space.

Prashant Nighot, Thomas Ma, 2020, Inflammatory bowel diseases

Investigating intestinal permeability and gut microbiota roles in acute coronary syndrome patients

T. Alhmoud, A. Kumar, Chien Chi Lo, Rana Al-Sadi, Stacey Clegg, Ihab Alomari, T. Zmeili, Cheryl Diane Gleasne, Kim Mcmurry, Armand Earl Ko Dichosa, Momchiloo Vuyisich, Patrick Sam Guy Chain, Shiraz Mishra, Thomas Ma, 2019, Human Microbiome Journal

Intestinal epithelial tight junction barrier regulation by autophagy-related protein ATG6/beclin 1

Morgan Wong, Ashwinkumar Subramenium Ganapathy, Eric Suchanec, Laura Laidler, Thomas Ma, Prashant Nighot, 2019, American Journal of Physiology - Cell Physiology on p. C753-C765

Lipopolysaccharide-Induced Increase in Intestinal Permeability Is Mediated by TAK-1 Activation of IKK and MLCK/MYLK Gene

Meghali Nighot, Manmeet Rawat, Rana Al-Sadi, Eliseo F. Castillo, Prashant Nighot, Thomas Ma, 2019, American Journal of Pathology on p. 797-812

MMP-9-induced increase in intestinal epithelial tight permeability is mediated by p38 kinase signaling pathway activation of MLCK gene

Rana Al-Sadi, Moustafa Youssef, Manmeet Rawat, Shuhong Guo, Karol Dokladny, Mohammad Haque, Martin D. Watterson, Thomas Y. Ma, 2019, American Journal of Physiology - Gastrointestinal and Liver Physiology on p. G278-G290

Expression of programmed death-ligand 1 by human colonic CD90<sup>+</sup> stromal cells differs between ulcerative colitis and Crohn's disease and determines their capacity to suppress Th1 cells

Ellen J. Beswick, Carl Grim, Abinav Singh, Jose E. Aguirre, Marissa Tafoya, Suimin Qiu, Gerhard Rogler, Rohini McKee, Von Samedi, Thomas Y. Ma, Victor E. Reyes, Don W. Powell, Irina V. Pinchuk, 2018, Frontiers in immunology

Lipopolysaccharide-Induced Increase in Intestinal Epithelial Tight Permeability Is Mediated by Toll-Like Receptor 4/Myeloid Differentiation Primary Response 88 (MyD88) Activation of Myosin Light Chain Kinase Expression

Meghali Nighot, Rana Al-Sadi, Shuhong Guo, Manmeet Rawat, Prashant Nighot, Martin D. Watterson, Thomas Ma, 2017, American Journal of Pathology on p. 2698-2710

Chloride channel ClC- 2 enhances intestinal epithelial tight junction barrier function via regulation of caveolin-1 and caveolar trafficking of occludin

Prashant K. Nighot, Lana Leung, Thomas Y. Ma, 2017, Experimental Cell Research on p. 113-122

Intestinal barrier dysfunction in human necrotizing enterocolitis

Sarah A. Moore, Prashant Nighot, Cynthia Reyes, Manmeet Rawat, Jason McKee, David Lemon, Joshua Hanson, Thomas Y. Ma, 2016, Journal of pediatric surgery on p. 1907-1913

Role of autophagy in the regulation of epithelial cell junctions.

Prashant Nighot, Thomas Ma, 2016, Tissue barriers on p. e1171284

Most-Cited Papers

Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier

Rana Al-Sadi, Khaldun Khatib, Shuhong Guo, Dongmei Ye, Moustafa Youssef, Thomas Ma, 2011, American Journal of Physiology - Gastrointestinal and Liver Physiology on p. G1054-G1064

Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14

Shuhong Guo, Rana Al-Sadi, Hamid M. Said, Thomas Ma, 2013, American Journal of Pathology on p. 375-387

MicroRNA regulation of intestinal epithelial tight junction permeability

Dongmei Ye, Shuhong Guo, Rana Al-Sadi, Thomas Ma, 2011, Gastroenterology on p. 1323-1333

IL-1β-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-κB pathway

Rana Al-Sadi, Dongmei Ye, Hamid M. Said, Thomas Y. Ma, 2010, American Journal of Pathology on p. 2310-2322

TNF-α modulation of intestinal epithelial tight junction barrier is regulated by ERK1/2 activation of Elk-1

Rana Al-Sadi, Shuhong Guo, Dongmei Ye, Thomas Ma, 2013, American Journal of Pathology on p. 1871-1884

Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway

Rana Al-Sadi, Dongmei Ye, Michel Boivin, Shuhong Guo, Mariam Hashimi, Lisa Ereifej, Thomas Y. Ma, 2014, PloS one

Lipopolysaccharide regulation of intestinal tight junction permeability is mediated by TLR4 signal transduction pathway activation of FAK and MyD88

Shuhong Guo, Meghali Nighot, Rana Al-Sadi, Tarik Alhmoud, Prashant Nighot, Thomas Ma, 2015, Journal of Immunology on p. 4999-5010

LPS-induced cytokine levels are repressed by elevated expression of HSP70 in rats

Karol Dokladny, Rebecca Lobb, Walker Wharton, Thomas Y. Ma, Pope L. Moseley, 2010, Cell Stress and Chaperones on p. 153-163

Mechanism of IL-1β modulation of intestinal epithelial barrier involves p38 kinase and activating transcription factor-2 activation

Rana Al-Sadi, Shuhong Guo, Dongmei Ye, Karol Dokladny, Tarik Alhmoud, Lisa Ereifej, Hamid M. Said, Thomas Ma, 2013, Journal of Immunology on p. 6596-6606

Autophagy enhances intestinal epithelial tight junction barrier function by targeting claudin-2 protein degradation

Prashant K. Nighot, Chien An Andy Hu, Thomas Y. Ma, 2015, Journal of Biological Chemistry on p. 7234-7246