Thomas Ma
Professor and Chair of Medicine
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500 University Drive
Hershey, PA - tum606@psu.edu
Huck Affiliations
Most Recent Publications
Bifidobacterium bifidum Strain BB1 Inhibits Tumor Necrosis Factor-α–Induced Increase in Intestinal Epithelial Tight Junction Permeability via Toll-Like Receptor-2/Toll-Like Receptor-6 Receptor Complex–Dependent Stimulation of Peroxisome Proliferator-Activated Receptor γ and Suppression of NF-κB p65
Raz Abdulqadir, Rana Al-Sadi, Mohammad Haque, Yash Gupta, Manmeet Rawat, Thomas Y. Ma, 2024, American Journal of Pathology on p. 1664-1683
The complete genome sequence of probiotic Lactobacillus acidophilus ATCC 9224 isolated from sour milk
Anand Kumar, Manmeet Rawat, Yuliya A. Kunde, Karen W. Davenport, Rana Al-Sadi, Patrick Sam Guy Chain, Thomas Y. Ma, 2024, Genome Announcements
Lactobacillus acidophilus inhibits the TNF-α-induced increase in intestinal epithelial tight junction permeability via a TLR-2 and PI3K-dependent inhibition of NF-κB activation
Mohammad Haque, Lauren Kaminsky, Raz Abdulqadir, Jessica Engers, Evgeny Kovtunov, Manmeet Rawat, Rana Al-Sadi, Thomas Y. Ma, 2024, Frontiers in Immunology
Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways
A Ganapathy, K Saha, A Wang, P Arumugam, V Dharmaprakash, Gregory Yochum, Walter Koltun, M Nighot, Gary H. Perdew, T Thompson, Thomas Ma, Prashant Nighot, 2023, Cell Reports on p. 112705
Editorial: Role of matrix metalloproteinases and other inflammatory mediators in the disruption of the intestinal tight junction barrier
Rana Al-Sadi, Raz Abdulqadir, Thomas Ma, 2023, Frontiers in Immunology
Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation
Kushal Saha, Ashwinkumar Subramenium Ganapathy, Alexandra Wang, Priya Arumugam, Nathan Michael Morris, Leonard Harris, Gregory Yochum, Walter Koltun, Gary H. Perdew, Meghali Nighot, Thomas Ma, Prashant Nighot, 2023, Mucosal Immunology
NASHFit: A randomized controlled trial of an exercise training program to reduce clotting risk in patients with NASH
Jonathan G. Stine, Ian R. Schreibman, Alison J. Faust, Jessica Dahmus, Benjamin Stern, Christopher Soriano, Gloriany Rivas, Breianna Hummer, Scot R. Kimball, Nate R. Geyer, Vernon M. Chinchilli, Rohit Loomba, Kathryn Schmitz, Christopher Sciamanna, Cindy Strine, Rachel Wentzel, Sara Marlin, Chris Sica, Jeff Vesek, Elaine Eyster, Lawrence Sinoway, Kathy Bentz, Nancy Handley, Brenda Hershey Fell, Shirlynn Mottilla, Christine Christ, Susan George, Terry Novchich, Megan Beyer, Kofi Clarke, Tiffany Myers, Martha Glading-Steinruck, Karen Krok, Thomas Ma, Thomas Riley, Elizabeth Thompson, Heather Tressler, James Broach, Trang Doan, Sue Patrick, Syndi Reed, Chris Hamilton, Kristin Slavoski, Deborah Tregea, 2022, Hepatology on p. 172-185
IL-1β and the Intestinal Epithelial Tight Junction Barrier
Lauren W. Kaminsky, Rana Al-Sadi, Thomas Y. Ma, 2021, Frontiers in Immunology
Matrix Metalloproteinase MMP-12 Promotes Macrophage Transmigration across Intestinal Epithelial Tight Junctions and Increases Severity of Experimental Colitis
Meghali Nighot, Ashwinkumar Subramenium Ganapathy, Kushal Saha, Eric Suchanec, Eliseo F. Castillo, Alyssa Gregory, Steven Shapiro, Thomas Ma, Prashant Nighot, 2021, Journal of Crohn's and Colitis on p. 1751-1765
Bifidobacterium bifidum enhances the intestinal epithelial tight junction barrier and protects against intestinal inflammation by targeting the toll-like receptor-2 pathway in an nf-κb-independent manner
Rana Al-Sadi, V Dharmaprakash, Prashant Nighot, S Guo, Meghali Nighot, T Do, Thomas Ma, 2021, International Journal of Molecular Sciences
Most-Cited Papers
Lipopolysaccharide regulation of intestinal tight junction permeability is mediated by TLR4 signal transduction pathway activation of FAK and MyD88
Shuhong Guo, Meghali Nighot, Rana Al-Sadi, Tarik Alhmoud, Prashant Nighot, Thomas Ma, 2015, Journal of Immunology on p. 4999-5010
IL-1β and the Intestinal Epithelial Tight Junction Barrier
Lauren W. Kaminsky, Rana Al-Sadi, Thomas Y. Ma, 2021, Frontiers in Immunology
Autophagy enhances intestinal epithelial tight junction barrier function by targeting claudin-2 protein degradation
Prashant K. Nighot, Chien An Andy Hu, Thomas Y. Ma, 2015, Journal of Biological Chemistry on p. 7234-7246
TNF-α Modulation of Intestinal Tight Junction Permeability Is Mediated by NIK/IKK-α Axis Activation of the Canonical NF-κB Pathway
Rana Al-Sadi, Shuhong Guo, Dongmei Ye, Manmeet Rawat, Thomas Y. Ma, 2016, American Journal of Pathology on p. 1151-1165
Lipopolysaccharide-Induced Increase in Intestinal Epithelial Tight Permeability Is Mediated by Toll-Like Receptor 4/Myeloid Differentiation Primary Response 88 (MyD88) Activation of Myosin Light Chain Kinase Expression
Meghali Nighot, Rana Al-Sadi, Shuhong Guo, Manmeet Rawat, Prashant Nighot, Martin D. Watterson, Thomas Y. Ma, 2017, American Journal of Pathology on p. 2698-2710
IL1B Increases Intestinal Tight Junction Permeability by Up-regulation of MIR200C-3p, Which Degrades Occludin mRNA
M Rawat, K Rawat, Walter Koltun, Meghali Nighot, G Yochum, Rana Al-Sadi, Y Gupta, D Viszwapriya, Gregory Yochum, Thomas Y. Ma, 2020, Gastroenterology on p. 1375-1389
Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis
Prashant Nighot, Rana Al-Sadi, Manmeet Rawat, Shuhong Guo, D. Martin Watterson, Thomas Ma, 2015, American Journal of Physiology on p. G988-G997
Bifidobacterium bifidum enhances the intestinal epithelial tight junction barrier and protects against intestinal inflammation by targeting the toll-like receptor-2 pathway in an nf-κb-independent manner
Rana Al-Sadi, V Dharmaprakash, Prashant Nighot, S Guo, Meghali Nighot, T Do, Thomas Ma, 2021, International Journal of Molecular Sciences
Lipopolysaccharide-Induced Increase in Intestinal Permeability Is Mediated by TAK-1 Activation of IKK and MLCK/MYLK Gene
Meghali Nighot, Manmeet Rawat, Rana Al-Sadi, Eliseo F. Castillo, Prashant Nighot, Thomas Y. Ma, 2019, American Journal of Pathology on p. 797-812
Intestinal barrier dysfunction in human necrotizing enterocolitis
Sarah A. Moore, Prashant Nighot, Cynthia Reyes, Manmeet Rawat, Jason McKee, David Lemon, Joshua Hanson, Thomas Y. Ma, 2016, Journal of Pediatric Surgery on p. 1907-1913