Thomas Ma

Professor and Chair of Medicine

Thomas Ma

Huck Affiliations

Publication Tags

Tight Junctions Permeability Caco 2 Cells Intestinal Mucosa Myosin Light Chain Kinase Inflammation Inbred C57bl Mouse Ethanol Lipopolysaccharides Transcriptional Activation Up Regulation Signal Transduction Tight Junction Proteins Matrix Metalloproteinase 9 Mice Claudin 2 Interleukin 1beta Toll Like Receptor 4 Interleukin 1 Knockout Mice Small Interfering Rna Phosphotransferases Colitis Enterocytes Epithelial Cells

Most Recent Publications

NASHFit: A randomized controlled trial of an exercise training program to reduce clotting risk in patients with NASH

Jonathan G. Stine, Ian R. Schreibman, Alison J. Faust, Jessica Dahmus, Benjamin Stern, Christopher Soriano, Gloriany Rivas, Breianna Hummer, Scot R. Kimball, Nate R. Geyer, Vernon M. Chinchilli, Rohit Loomba, Kathryn Schmitz, Christopher Sciamanna, Cindy Strine, Rachel Wentzel, Sara Marlin, Chris Sica, Jeff Vesek, Elaine Eyster, Lawrence Sinoway, Kathy Bentz, Nancy Handley, Brenda Hershey Fell, Shirlynn Mottilla, Christine Christ, Susan George, Terry Novchich, Megan Beyer, Kofi Clarke, Tiffany Myers, Martha Glading-Steinruck, Karen Krok, Thomas Ma, Thomas Riley, Elizabeth Thompson, Heather Tressler, James Broach, Trang Doan, Sue Patrick, Syndi Reed, Chris Hamilton, Kristin Slavoski, Deborah Tregea, 2022, Hepatology on p. 172-185

IL-1β and the Intestinal Epithelial Tight Junction Barrier

Lauren W. Kaminsky, Rana Al-Sadi, Thomas Y. Ma, 2021, Frontiers in Immunology

Matrix Metalloproteinase MMP-12 Promotes Macrophage Transmigration across Intestinal Epithelial Tight Junctions and Increases Severity of Experimental Colitis

Meghali Nighot, Ashwinkumar Subramenium Ganapathy, Kushal Saha, Eric Suchanec, Eliseo F. Castillo, Alyssa Gregory, Steven Shapiro, Thomas Ma, Prashant Nighot, 2021, Journal of Crohn's and Colitis on p. 1751-1765

Lactobacillus acidophilus Induces a Strain-specific and Toll-Like Receptor 2–Dependent Enhancement of Intestinal Epithelial Tight Junction Barrier and Protection Against Intestinal Inflammation

Rana Al-Sadi, Prashant Nighot, Meghali Nighot, Mohammad Haque, Manmeet Rawat, Thomas Y. Ma, 2021, American Journal of Pathology on p. 872-884

Matrix Metalloproteinase-9 (MMP-9) induced disruption of intestinal epithelial tight junction barrier is mediated by NF-κB activation

Rana Al-Sadi, Jessica Engers, Mohammad Haque, Steven King, Deemah Al-Omari, Thomas Y. Ma, 2021, PLoS One

Endocytosis of Intestinal Tight Junction Proteins: In Time and Space

Prashant Nighot, Thomas Ma, 2021, Inflammatory Bowel Diseases on p. 283-290

The gut microbiome and alcoholic liver disease: Ethanol consumption drives consistent and reproducible alteration in gut microbiota in mice

Erick S. Lebrun, Meghali Nighot, Viszwapriya Dharmaprakash, Anand Kumar, Chien Chi Lo, Patrick S.G. Chain, Thomas Y. Ma, 2021, Life on p. 1-11

AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability

A Ganapathy, K Saha, E Suchanec, V Singh, A Verma, Gregory Yochum, Walter Koltun, Meghali Nighot, Thomas Ma, Prashant Nighot, 2021, Autophagy on p. 1-18

IL1B Increases Intestinal Tight Junction Permeability by Up-regulation of MIR200C-3p, Which Degrades Occludin mRNA.

M Rawat, Meghali Nighot, Rana Al-Sadi, Y Gupta, D Viszwapriya, Gregory Yochum, Walter Koltun, Thomas Y. Ma, 2020, Gastroenterology on p. 1375-1389

Investigating intestinal permeability and gut microbiota roles in acute coronary syndrome patients

T. Alhmoud, A. Kumar, Chien Chi Lo, Rana Al-Sadi, Stacey Clegg, Ihab Alomari, T. Zmeili, Cheryl Diane Gleasne, Kim Mcmurry, Armand Earl Ko Dichosa, Momchiloo Vuyisich, Patrick Sam Guy Chain, Shiraz Mishra, Thomas Ma, 2019, Human Microbiome Journal

Most-Cited Papers

Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14

Shuhong Guo, Rana Al-Sadi, Hamid M. Said, Thomas Ma, 2013, American Journal of Pathology on p. 375-387

Lipopolysaccharide regulation of intestinal tight junction permeability is mediated by TLR4 signal transduction pathway activation of FAK and MyD88

Shuhong Guo, Meghali Nighot, Rana Al-Sadi, Tarik Alhmoud, Prashant Nighot, Thomas Ma, 2015, Journal of Immunology on p. 4999-5010

TNF-α modulation of intestinal epithelial tight junction barrier is regulated by ERK1/2 activation of Elk-1

Rana Al-Sadi, Shuhong Guo, Dongmei Ye, Thomas Y. Ma, 2013, American Journal of Pathology on p. 1871-1884

Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway

Rana Al-Sadi, Dongmei Ye, Michel Boivin, Shuhong Guo, Mariam Hashimi, Lisa Ereifej, Thomas Y. Ma, 2014, PLoS One

TNF-α Modulation of Intestinal Tight Junction Permeability Is Mediated by NIK/IKK-α Axis Activation of the Canonical NF-κB Pathway

Rana Al-Sadi, Shuhong Guo, Dongmei Ye, Manmeet Rawat, Thomas Y. Ma, 2016, American Journal of Pathology on p. 1151-1165

Autophagy enhances intestinal epithelial tight junction barrier function by targeting claudin-2 protein degradation

Prashant K. Nighot, Chien An Andy Hu, Thomas Y. Ma, 2015, Journal of Biological Chemistry on p. 7234-7246

Mechanism of IL-1β modulation of intestinal epithelial barrier involves p38 kinase and activating transcription factor-2 activation

Rana Al-Sadi, Shuhong Guo, Dongmei Ye, Karol Dokladny, Tarik Alhmoud, Lisa Ereifej, Hamid M. Said, Thomas Ma, 2013, Journal of Immunology on p. 6596-6606

Lipopolysaccharide-Induced Increase in Intestinal Epithelial Tight Permeability Is Mediated by Toll-Like Receptor 4/Myeloid Differentiation Primary Response 88 (MyD88) Activation of Myosin Light Chain Kinase Expression

Meghali Nighot, Rana Al-Sadi, Shuhong Guo, Manmeet Rawat, Prashant Nighot, Martin D. Watterson, Thomas Y. Ma, 2017, American Journal of Pathology on p. 2698-2710

Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis

Prashant Nighot, Rana Al-Sadi, Manmeet Rawat, Shuhong Guo, D. Martin Watterson, Thomas Ma, 2015, American Journal of Physiology on p. G988-G997

Mechanism of Interleukin-1β induced-increase in mouse intestinal permeability in vivo

Rana Al-Sadi, Shuhong Guo, Karol Dokladny, Matthew A. Smith, Dongmei Ye, Archana Kaza, D. Martin Watterson, Thomas Ma, 2012, Journal of Interferon and Cytokine Research on p. 474-484