Thomas Ma

Professor and Chair of Medicine

Thomas Ma

Huck Affiliations

Publication Tags

Tight Junctions Permeability Caco 2 Cells Intestinal Mucosa Myosin Light Chain Kinase Ethanol Lipopolysaccharides Occludin Intestines Inflammatory Bowel Diseases Transcriptional Activation Small Interfering Rna Genes Transfection Inflammation Epithelial Cells Enterocytes Crohn Disease Map Kinase Signaling System Inbred C57bl Mouse Up Regulation Matrix Metalloproteinase 9 Mice Tumor Necrosis Factor Alpha Interleukin 1beta

Most Recent Papers

Lactobacillus acidophilus Induces a Strain-specific and Toll-Like Receptor 2–Dependent Enhancement of Intestinal Epithelial Tight Junction Barrier and Protection Against Intestinal Inflammation

Rana Al-Sadi, Prashant Nighot, Meghali Nighot, Mohammad Haque, Manmeet Rawat, Thomas Y. Ma, 2021, American Journal of Pathology on p. 872-884

Matrix Metalloproteinase-9 (MMP-9) induced disruption of intestinal epithelial tight junction barrier is mediated by NF-κB activation

Rana Al-Sadi, Jessica Engers, Mohammad Haque, Steven King, Deemah Al-Omari, Thomas Y. Ma, 2021, PLoS One

Endocytosis of Intestinal Tight Junction Proteins

Prashant Nighot, Thomas Ma, 2021, Inflammatory Bowel Diseases on p. 283-290

The gut microbiome and alcoholic liver disease

Erick S. Lebrun, Meghali Nighot, Viszwapriya Dharmaprakash, Anand Kumar, Chien Chi Lo, Patrick S.G. Chain, Thomas Y. Ma, 2021, Life on p. 1-11

IL1B Increases Intestinal Tight Junction Permeability by Up-regulation of MIR200C-3p, Which Degrades Occludin mRNA

Manmeet Rawat, Meghali Nighot, Rana Al-Sadi, Yash Gupta, Dharmaprakash Viszwapriya, Gregory Yochum, Walter Koltun, Thomas Y. Ma, 2020, Gastroenterology on p. 1375-1389

Investigating intestinal permeability and gut microbiota roles in acute coronary syndrome patients

T. Alhmoud, A. Kumar, Chien Chi Lo, Rana Al-Sadi, Stacey Clegg, Ihab Alomari, T. Zmeili, Cheryl Diane Gleasne, Kim Mcmurry, Armand Earl Ko Dichosa, Momchiloo Vuyisich, Patrick Sam Guy Chain, Shiraz Mishra, Thomas Ma, 2019, Human Microbiome Journal

Intestinal epithelial tight junction barrier regulation by autophagy-related protein ATG6/beclin 1

Morgan Wong, Ashwinkumar Subramenium Ganapathy, Eric Suchanec, Laura Laidler, Thomas Ma, Prashant Nighot, 2019, American Journal of Physiology on p. C753-C765

Lipopolysaccharide-induced increase in intestinal permeability is mediated by TAK-1 activation of IKK and MLCK/MYLK gene

Meghali Nighot, Manmeet Rawat, Rana Al-Sadi, Eliseo F. Castillo, Prashant Nighot, Thomas Y. Ma, 2019, American Journal of Pathology on p. 797-812

MMP-9-induced increase in intestinal epithelial tight permeability is mediated by p38 kinase signaling pathway activation of MLCK gene

Rana Al-Sadi, Moustafa Youssef, Manmeet Rawat, Shuhong Guo, Karol Dokladny, Mohammad Haque, Martin D. Watterson, Thomas Y. Ma, 2019, American Journal of Physiology on p. G278-G290

Expression of programmed death-ligand 1 by human colonic CD90<sup>+</sup> stromal cells differs between ulcerative colitis and Crohn's disease and determines their capacity to suppress Th1 cells

Ellen J. Beswick, Carl Grim, Abinav Singh, Jose E. Aguirre, Marissa Tafoya, Suimin Qiu, Gerhard Rogler, Rohini McKee, Von Samedi, Thomas Y. Ma, Victor E. Reyes, Don W. Powell, Irina V. Pinchuk, 2018, Frontiers in Immunology

Most-Cited Papers

Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14

Shuhong Guo, Rana Al-Sadi, Hamid M. Said, Thomas Ma, 2013, American Journal of Pathology on p. 375-387

Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier

Rana Al-Sadi, Khaldun Khatib, Shuhong Guo, Dongmei Ye, Moustafa Youssef, Thomas Ma, 2011, American Journal of Physiology on p. G1054-G1064

MicroRNA regulation of intestinal epithelial tight junction permeability

Dongmei Ye, Shuhong Guo, Rana Al-Sadi, Thomas Ma, 2011, Gastroenterology on p. 1323-1333

Lipopolysaccharide regulation of intestinal tight junction permeability is mediated by TLR4 signal transduction pathway activation of FAK and MyD88

Shuhong Guo, Meghali Nighot, Rana Al-Sadi, Tarik Alhmoud, Prashant Nighot, Thomas Ma, 2015, Journal of Immunology on p. 4999-5010

Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway

Rana Al-Sadi, Dongmei Ye, Michel Boivin, Shuhong Guo, Mariam Hashimi, Lisa Ereifej, Thomas Y. Ma, 2014, PLoS One

TNF-α modulation of intestinal epithelial tight junction barrier is regulated by ERK1/2 activation of Elk-1

Rana Al-Sadi, Shuhong Guo, Dongmei Ye, Thomas Y. Ma, 2013, American Journal of Pathology on p. 1871-1884

TNF-α Modulation of Intestinal Tight Junction Permeability Is Mediated by NIK/IKK-α Axis Activation of the Canonical NF-κB Pathway

Rana Al-Sadi, Shuhong Guo, Dongmei Ye, Manmeet Rawat, Thomas Y. Ma, 2016, American Journal of Pathology on p. 1151-1165

Autophagy enhances intestinal epithelial tight junction barrier function by targeting claudin-2 protein degradation

Prashant K. Nighot, Chien An Andy Hu, Thomas Y. Ma, 2015, Journal of Biological Chemistry on p. 7234-7246

Mechanism of IL-1β modulation of intestinal epithelial barrier involves p38 kinase and activating transcription factor-2 activation

Rana Al-Sadi, Shuhong Guo, Dongmei Ye, Karol Dokladny, Tarik Alhmoud, Lisa Ereifej, Hamid M. Said, Thomas Ma, 2013, Journal of Immunology on p. 6596-6606

Mechanism of Interleukin-1β induced-increase in mouse intestinal permeability in vivo

Rana Al-Sadi, Shuhong Guo, Karol Dokladny, Matthew A. Smith, Dongmei Ye, Archana Kaza, D. Martin Watterson, Thomas Ma, 2012, Journal of Interferon and Cytokine Research on p. 474-484